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Dissertations / Theses on the topic 'Basic Biochemistry'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Barry, Richard David. "Antibodies to myelin basic protein : their production, characterization and application." Thesis, Oxford Brookes University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278392.

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2

Dawkes, Adrian Charles. "Immunochemical studies on myelin basic protein using monoclonal polyclonal antibodies." Thesis, Open University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234745.

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3

Ulmer, Jeffrey Blaine. "The phosphorylation of myelin basic proteins and its relevance to myelin biogenesis /." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=72045.

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Age-related differences in the in vivo incorporation of 32-P into mouse myelin basic proteins (MBPs) of the central nervous system were observed. The resulting specific radioactivity (S.A.) of the MBPs appeared to be related to the S.A. of the acid-soluble pool of phosphates of myelin. In development, MBPs were phosphorylated in vivo prior to the onset of myelination in the brain, indicating that MBPs are phosphorylated prior to their deposition in the myelin sheath.<br>The incorporation of 32-P into MBPs and the turnover rates of MBP phosphates were studied in vivo in developmentally-related

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4

Li, Ming-Shi. "Structure and expression of the gene encoding human eosinophil major basic protein." Thesis, St George's, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307257.

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5

Li, Shuo. "Mechanisms of Neurodegeneration in Multiple Sclerosis: Possible Roles of N-acetylaspartate, Hemoglobin and Myelin Basic Protein." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1436478236.

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6

Snape, M. M. "The 'basic' polygalacturonase secreted by Monilinia fructigena and some aspects of the speciation of the genus." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373854.

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7

Jia, Xiaolin. "Development of a Simple Microfluidic Device for Characterizing Chemotaxis of Macrophage in Response to Myelin Basic Protein." Thesis, The Florida State University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10287708.

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<p> Microfluidic devices are widely used for cell-based analysis. There are always needs to develop simpler, more effective and/or less costly devices than the existing ones for this application. A simple microfluidic device has been fabricated and tested for studying chemotaxis of macrophages in this study. The device was made of polydimethylsiloxane bound to a cell culture dish. It consisted of a millimeter-sized cavum and two arrays of straight channels of 5 um in width and 6um height and about two millimeters in length. The channels connected the cavum, in which a chemoattractant was loade

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8

Azzam, Sausan. "Protein Profiling Analysis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis Brain Tissue." Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1302472724.

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9

Figueira, Angela Carine Moura. "Atividades experimentais em bioquímica básica: um estudo baseado na resolução de problemas em diferentes níveis de ensino." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/3535.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The Problem Based Learning (PBL) can be a valuable tool in Science Teaching, encouraging curiosity and motivation of the student. In this thesis we use PBL trying to help the teaching of basic biochemistry. The first step of this study was to investigate the students' preconceptions about proteins, sugars and lipids, which helped us to guide both the proposed activities in the didactic notebook What We eat and We drink? as the discussions in the classroom during the application of those activities. The population studied was

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10

Serrano, Moises A. "Novel Roles of Replication Protein A Phosphorylation in Cellular Response to DNA Damage." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etd/1206.

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Human replication protein A (RPA) is an eukaryotic single-stranded DNA binding protein directly involved in a variety of DNA metabolic pathways including replication, recombination, DNA damage checkpoints and signaling, as well as all DNA repair pathways. This project presents 2 novel roles of RPA in the cellular response to DNA damage. The first elucidates the regulation of RPA and p53 interaction by DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) in homologous recombination (HR). HR and nonhomologous end joining (NHEJ) are 2 distinct

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11

Miskalo, André Kisil. "Verificação do conteúdo de disciplinas de bioquímica por análise e classificação de questões de provas." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-26112010-093303/.

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Um problema freqüentemente encontrado por educadores nas mais diversas áreas é conciliar o volume crescente de informação com a manutenção e/ou, não raro, a diminuição das cargas horárias de seus cursos. Esta situação real necessariamente obriga o educador a fazer uma severa seleção dos conteúdos a serem trabalhados. No cenário atual da maior parte das instituições de ensino esta decisão é tomada pelo professor. É possível estabelecer metodologias novas de ensino ao longo do tempo sem abrir mão da qualidade do ensino. Para isso, é necessário em primeiro lugar determinar os conteúdos considerad

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12

Lekholm, Emilia. "Solute Carriers in Metabolism : Regulation of known and putative solute carriers in the central nervous system." Doctoral thesis, Uppsala universitet, Funktionell farmakologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-331328.

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Solute carriers (SLCs) are membrane-bound transporter proteins, important for nutrient, ion, drug and metabolite transport across membranes. A quarter of the human genome codes for membrane-bound proteins, and SLCs make up the largest group of transporter proteins. Due to their ability to transport a large repertoire of substances across, not just the plasma membrane, but also the membrane of internal organelles, they hold a key position in maintaining homeostasis affecting metabolic pathways. Unfortunately, some of the more than 400 identified SLCs are still not fully characterized, even thou

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13

Shahidi, Dadras Mahsa. "Regulation of cell polarity and invasion by TGF-β and BMP signaling". Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-334409.

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Transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP) signaling pathways are involved in many physiological processes during embryonic and adult life. TGF-β promotes epithelial to mesenchymal transition (EMT). We identified a gene target of TGF-β signaling, encoding the salt-inducible kinase 1 (SIK1). A potential substrate of this kinase, the polarity protein Par3, is an established regulator of tight junction assembly. SIK1 associates with Par3, can potentially phosphorylate Par3 and leads to its degradation, contributing to tight junction disassembly. Glioblastoma multifo

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14

Hill, Jenna D. "Validation of Antibodies Used to Study Hypoxia Inducible Factors in Two Species of Fundulus." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/td/1636.

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Hypoxia inducible factors (HIFs) are transcription factors and the master regulators of oxygen-dependent gene expression in animals. The focus of this thesis is the distribution of HIF protein in tissues of the fish Fundulus heteroclitus and F. grandis, two widespread species that occur in naturally hypoxic waters. Polyclonal antibodies against HIF-1α, HIF-2α, and HIF-3α were tested on proteins made in vitro and on extracts made from several tissues of normoxic and hypoxic fish. Antibodies against HIF-1α and 3α bound specifically to full length protein made in vitro, and produced bands on west

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15

Horley, Neill. "Molecular basis of CYP2B2 induction." Thesis, University of Nottingham, 1999. http://eprints.nottingham.ac.uk/10397/.

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Many structurally unrelated chemicals can induce members of the cytochrome P450 superfamily with phenobarbital (PB) being a typical example. PB induces CYP2B1/2, which are most highly expressed in the liver. Their mechanism of activation has not yet been elucidated, with advances hampered by the absence of a suitable cell culture system to mimic the in vivo PB-mediated induction. During this thesis a primary rat hepatocyte culture system has been developed which is highly responsive to PB at both RNA and protein levels. A sensitive and specific RNAse protection assay (RPA) has been used to dem

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16

Nagano, Soshichiro. "Structural basis of light dependent modulation of phytochrome." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8646.

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This thesis presents structural and biochemical studies of a phytochrome, Agp1, a bilin-binding red-light receptor protein. Crystallographic studies were undertaken in order to obtain structural insight into the mechanism of photoconversion and signal transduction from the sensor domain to the signalling domain, the latter hypothesised to be universally conserved among two-component histidine kinases. Using Agp1 from a non-photosynthetic plant pathogen, Agrobacterium tumefaciens as a model phytochrome, structural determination of both Pr and Pfr-forms was attempted, in order to permit unbiased

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17

Hillmen, Peter. "The biochemical and cellular basis of paroxysmal nocturnal haemoglobinuria." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338391.

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18

Garcia-Moreno, Pamela K. "Mycobacterium tuberculosis inhibitors: action and resistance." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3893.

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Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis, has been a global health problem for years. The emergence of drug resistance in this organism generates the necessity of exploring novel targets and developing new drugs. Topoisomerases are enzymes found in all kingdoms of life responsible for overcoming the topological barriers encountered during essential cellular processes. The genomes of mycobacteria encode only one type IA topoisomerase (MtopI), which has been validated as a novel TB drug target. The goal of this study is to obtain new information on the mechanism a

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19

Borglin, Matthew R. "Analysis of Biofilm Remediation Capacity For Octenyl Succinic Anhydride (OSA), A Bioactive Food Starch Modifier Compound." DigitalCommons@CalPoly, 2020. https://digitalcommons.calpoly.edu/theses/2168.

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Matthew R. Borglin This thesis demonstrates efficacy of Octenyl Succinic Anhydride (OSA), as a biofilm sanitizer. Biofilms allow bacteria to adhere to solid surfaces with the use of excreted polymeric compounds. For example, surfaces found in food production or processing facilities such as the interior of a raw milk holding tank, are some of the most susceptible to biofilm contamination. When present, biofilms can cause a variety of negative effects, which include; reduction of product shelf life, corrosion, and outbreaks of foodborne illnesses. The close association of biofilms with the majo

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20

Tuomi, William Victor. "Molecular basis for the enantiopreference of lipase from Pseudomonas cepacia." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20885.

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An empirical rule which predicts which enantiomer will be preferred by lipases (triacylglycerol hydrolases) based on the relative sizes of the substituents has previously been developed for secondary alcohols. This rule was then extended towards primary alcohols for lipase from Pseudomonas cepacia (PCL). However, the rule for primary alcohols shows an opposite enantiopreference compared to the rule for secondary alcohols. Furthermore, it is no longer valid when an oxygen lies at the stereocentre. This thesis explores the molecular basis for the empirical rule for primary alcohols and why the r

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21

Zhai, Yubo. "REDEFINING THE MOLECULAR BASIS OF EPITHELIAL MESENCHYMAL TRANSITION IN BREAST CANCER METASTASIS." Master's thesis, Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216586.

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Biochemistry<br>M.S.<br>Metastasis is a multi-step process that begins with cancer cells migrating and invading away from the primary tumor site and extravasating into distant organs to establish a secondary tumor. The loss of epithelial expression markers by neoplastic breast cancer cells in the primary tumor is believed to play a pivotal role during breast cancer metastasis. This phenomenon is the hallmark of the epithelial mesenchymal transition (EMT) process. Gene expression microarrays were performed to investigate key functional elements on an in vitro metastasis model derived from human

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22

Toyama, Brandon Hiroyuki. "The structural basis of yeast prion strain variants." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3378511.

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23

Kröger, Wendy Lee. "A molecular basis for the C-domain selectivity of angiotensin-converting enzyme." Doctoral thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3134.

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24

Ver, Heul Aaron Martin. "Molecular basis of Nod1 And Nod2 signaling." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/4784.

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NOD1 and NOD2 (nucleotide-binding oligomerization domain-containing proteins 1 and 2) are related innate immune receptors responsible for initiating a response to bacterial infection. They belong to a class of receptors known as Pattern Recognition Receptors (PRRs), which are germline encoded immune receptors that mediate various innate immune responses. These receptors recognize conserved microbial motifs known as Pathogen-Associated Molecular Patterns (PAMPs). The PRR-PAMP paradigm forms the bedrock of how innate immunity is understood today. As two of the first intracellular PRRs discovered

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25

Schrift, Greta Lynn. "Energetic consequences of structural features and dynamics changes upon nucleotide binding to ribonuclease SA molecular basis for nucleotide binding specificity /." Diss., University of Iowa, 2004. http://ir.uiowa.edu/etd/120.

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26

Fong, Desiree Ho-Chi. "Structural basis of ligand binding to 3',5'' -aminoglycoside O-phosphotransferase type IIIa." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100364.

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3',5"-aminoglycoside O-phosphotransferase type IIIa (APH(3')-IIIa) is an enzyme produced by pathogenic Gram-positive bacteria such as Enterococci and Staphylococci. It is capable of conferring resistance to a broad range of clinically important aminoglycoside antibiotics via the ATP-dependent addition of a phosphate to specific hydroxyl groups on the drug. The phosphorylated amino-glycoside loses its toxic effects due to reduced affinity for its target, the A-site of 30S ribosome. Crystal structures of several ternary complexes have been elucidated in an effort to understand the promiscuity of

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27

Buttle, D. J. "The biochemical basis for the use of chymopapain in the treatment of sciatica." Thesis, Anglia Ruskin University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303827.

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28

Waite, Richard David. "The molecular genetic basis of biofilm generated capsule phase variation in Strptococcus pneumoniae." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248865.

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29

Chittum, Harold S. "A Molecular Basis for Erythromycin Sensitivity and Resistance in Escherichia Coli." Digital Commons @ East Tennessee State University, 1993. https://dc.etsu.edu/etd/2655.

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The effect of erythromycin on the 50S ribosomal subunit during cell growth has been extensively investigated. Sucrose density gradient analysis of ribosomes formed in the presence and absence of the drug revealed a 50S specific assembly defect is partially responsible for erythromycin's inhibitory effects on wild type cells. Examination of two erythromycin-resistant mutants of E. coli (N281 and N282) revealed that mutant N281 (L22 mutant) but not N282 (L4 mutant) was assembly defective in the presence of the drug, although only at much higher drug concentrations (300 ug/ml vs. 75 ug/ml for wil

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30

Cooper, Roland Arthur 1963. "Pyrrolizidine alkaloids: Chemical basis of toxicity." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290581.

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In humans, livestock and experimental animals, pyrrolizidine alkaloids (PAs) are toxic as a consequence of their hepatic metabolism to reactive pyrrolic esters, or dehydroalkaloids (DHAs). Despite their similarity in structures, PAs often vary markedly in their lethality (LD₅₀s) and in the organs in which toxicity is expressed. We have examined whether there are differences in the physicochemical properties of certain DHAs which are associated with differences in patterns of metabolism and toxicity produced by the parent PA. Using a potentiometric method to measure hydrolysis, it was determine

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31

Chumnarnsilpa, Sakesit. "The Structural Basis of the Control of Actin Dynamics by the Gelsolin Superfamily Proteins." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89218.

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Rearrangement of the actin cytoskeleton occurs in a variety of cellular processes and structures and involves a wide spectrum of proteins. Among these, the gelsolin superfamily proteins (GSPs) control actin organization by severing filaments, capping filament ends and bundling filaments. Structural changes within the GSPs are key in controling their functions. This thesis is aimed in understanding the activation mechanisms of the C-terminal halves of GSPs through investigating the atomic structures of gelsolin, adseverin and villin. X-ray crystallography was used to determine the structures o

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32

Taylor, David W. Jr. "Structural Basis for RNA Processing by Human Dicer." Thesis, Yale University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3578460.

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<p> Dicer plays a central role in RNA interference pathways by cleaving double-stranded RNAs (dsRNAs) to produce small regulatory RNAs. Human Dicer can process long double-stranded and hairpin precursor RNAs to yield short interfering RNAs (siRNAs) or microRNAs (miRNAs), respectively. In humans, Argonaute2 (AGO2) assembles with the guide RNA-generating enzyme Dicer and either the RNA-binding protein TRBP or PACT to form a RISC-loading complex (RLC), which is necessary for efficient transfer of nascent siRNAs from Dicer to AGO2. Here, I have used electron microscopy and single particle analysis

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33

Yuan, Hai-Tao. "Molecular basis of respiratory distress syndrome and its acquired tolerance to oxygen toxicity in premature guinea-pig." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287202.

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34

Al-Daihan, Sooad K. "Study on human 5-aminolaevulinate synthase and the molecular basis for pyridoxine responsive X-linked sideroblastic anaemia." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390588.

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35

Stanway, Andrew Paul. "The biochemical basis of acid and alkali production by Rhizobium and Bradyrhizobium in the soil." Thesis, University of Reading, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329566.

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36

Howe, David S. "Biochemical basis of insect resistance in winged bean (Psophocarpus tetragonolbus) : characterisation of insecticidal proteins and their encoding genes." Thesis, Durham University, 1991. http://etheses.dur.ac.uk/6102/.

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Many pulses and beans grown for human comsumption are susceptible to insect attack. Winged bean, a high protein crop of the tropics, yield seeds which appear to be immune to infestation by the storage bruchid Callosobruchus maculatus. In this thesis the biochemical basis of this resisitance was investigated. Insect bio-assays were carried out in which protein fractions from seeds of winged bean were incorporated at a range of concentrations into artificial seeds, and their effects upon the development of C.maculatus determined. Both albumin and globulin fractions were toxic to the developing l

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37

Akbar, Mohammed Tariq. "Molecular basis of epilepsy : glutamate and gaba transporters and receptors in rodent models of genetic and acquired epilepsy." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286325.

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38

Al-Dbass, Abeer M. "Structural basis of acute intermittent porphyria and the relationship between mutations in human porphobilinogen deaminase and enzyme activity." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390590.

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39

Oudah, Dayana. "Development of a Healthy and Satiating Snack." Thesis, University of Kalmar, School of Pure and Applied Natural Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-960.

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<p><strong>ABSTRACT</strong></p><p>The demand of healthier products is increasing, and more people are more interested of what they eat. Statistics show that the consumption of snacks is rising.</p><p>Hyperglycemia leads to an increased risk for complications in type II diabetes mellitus. Increased levels of postprandial plasma glucose may also lead to equal or maybe more harmful effects than fasting hyperglycemia. When the levels of postprandial plasma glucose are decreased, the development of cardiovascular complications is delayed, why it is important to lower the snacks consumption especia

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40

Maltman, Daniel James. "Characterization of endoplasmic reticulum from castor bean and the cloning of a plant phosphatase : a basis for comprehensive plant organelle proteomics research." Thesis, Durham University, 2000. http://etheses.dur.ac.uk/4958/.

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The plant endoplasmic reticulum is the location of storage oil and membrane lipid assembly, and for fatty acid modifying reactions (desaturation, elongation, hydroxylation). It therefore represents a source of enzymes involved in these processes. Many of these defy traditional purification strategies. In this study, ER membranes have been isolated biochemically pure and in milligram quanties from the endosperm of developing and germinating castor bean. One-dimensional SDS- PAGE, used to routinely assess sample integrity, showed resolution limitations. Two-dimensional gel electrophoresis was op

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41

Toyama, Erin Quan. "The molecular basis of recognition and targeting of misfolded proteins by endoplasmic reticulum-associated degradation." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3378512.

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42

Guo, Hou-Fu. "NEUROPILIN IN THE VASCULAR SYSTEM: MECHANISTIC BASIS OF ANGIOGENESIS." UKnowledge, 2014. http://uknowledge.uky.edu/biochem_etds/16.

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The vascular system is critical for maintaining homeostasis in all vertebrates. Structural studies of Neuropilin (Nrp), an essential angiogenic receptor, have defined its role in regulating angiogenesis, the formation of new vessels from the existing vasculature. Utilizing biochemical and biophysical tools we describe the ability of Nrp to function as a co-receptor for the VEGFR receptor tyrosine kinase. Two families of Nrp-1 ligands, Vascular Endothelial Growth Factor A (VEGF-A) and Semaphorin3F (Sema3F), physically compete for binding to the Nrp-1 b1 domain, and have opposite roles. VEGF-A

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43

Liu, Wei. "Structural basis and functional impact of ligand-independent dimerization for human prolactin receptor." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1323893195.

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44

Barrett, Alexander Steven. "Structural Basis for Ternary Complex Formation Between tau, Hsp90, and FKBP51." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4436.

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The accumulation of the microtubule associated protein tau has been implicated in several neurological disorders; however, its interaction with chaperones along its normal degradation pathway remains largely uncharacterized at single residue resolution. In this study, nuclear magnetic resonance (NMR) spectroscopy was used to probe the interaction between tau, the molecular chaperone Hsp90, and the immunophilin FKBP51. Resonance intensity changes were observed for specific residues in the heteronuclear single quantum coherence (HSQC) spectra of 15N-labeled tau in the presence of Hsp90 and/or FK

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45

McKenney, Katherine Mary. "Investigating the basis of tRNA editing and modification enzyme coactivation in Trypanosoma brucei." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu152266963775877.

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46

Brady, Jacob Peter. "The molecular basis for ER tubule formation." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:fb5ce78d-0bc8-46dd-9552-04f1f1ec1d0f.

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Integral membrane proteins of the DP1 and reticulon families are responsible for maintaining the high membrane curvature required for both smooth ER tubules and the edges of ER sheets. Mutations in these proteins lead to motor neurone diseases such as hereditary spastic paraplegia. Reticulon/DP1 proteins contain Reticulon Homology Domains (RHD) that have unusually long (≈30 aa) hydrophobic segments and are proposed to adopt intramembrane helical hairpins that stabilise membrane curvature. I have uncovered the secondary structure and dynamics of the DP1 protein Yop1p and identified a C-te

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47

Redwine, William Bret. "The Structural Basis for Microtubule Binding and Release by Dynein." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10667.

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Eukaryotic cells face a considerable challenge organizing a complicated interior with spatial and temporal precision. They do so, in part, through the deployment of the microtubule- based molecular motors kinesin and dynein, which translate chemo-mechanical force production into the movement of diverse cargo. Many aspects of kinesin’s motility mechanism are now known in detail, whereas fundamental aspects of dynein’s motility mechanism remain unclear. An important unresolved question is how dynein couples rounds of ATP binding and hydrolysis to changes in affinity for its track, a requisite fo

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48

Perera, Hettiarachchige Dhanuja Deepamalee. "Molecular Basis of the Role of Kindlin 2 in Cell Adhesion." Cleveland State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=csu1295461683.

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49

Das, Vaijayanti. "STRUCTURAL BASIS OF LMAN1 CARGO CAPTURE IN ER & RELEASE IN ERGIC." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1343398252.

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50

Rodríguez, Torrecillas Ivan 1979. "Molecular basis to human P-glycoprotein reversion." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/586099.

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Abstract:

ABC (ATP-binding cassette) transporters are involved in translocate a wide spectrum of molecules across the lipid bilayer and some of them are associated with various diseases. They also have an important role in multidrug resistance (MDR) in cancer, which has been a major obstacle in cancer chemotherapy and in the treatment of leishmaniasis. While diverse transporters may confer MDR phenotype in bacteria, in human it is mainly achieved by five ABC proteins, among them P-glycoprotein/(ABCB1). To understand the structural basis of P-gp inhibitory activity, to determine the ligand bindi

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