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Journal articles on the topic 'Basophiles'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 January 2023

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1

Michel, Moïse, Eva Serrano, Joana Vitte, and Soraya Mezouar. "Mastocytes et basophiles." Revue Francophone des Laboratoires 2020, no. 521 (2020): 32–37. http://dx.doi.org/10.1016/s1773-035x(20)30125-8.

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2

David, B. "Mastocytes et basophiles." Revue Française d'Allergologie et d'Immunologie Clinique 28, no. 3 (1988): 213–24. http://dx.doi.org/10.1016/s0335-7457(88)80030-3.

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3

Dema, B., C. Pellefigues, Y. Lamri, et al. "Basophiles et auto-immunité." Revue Française d'Allergologie 56, no. 5 (2016): 446–48. http://dx.doi.org/10.1016/j.reval.2016.03.003.

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4

Bodger, MP, GL Mounsey, J. Nelson, and PH Fitzgerald. "A monoclonal antibody reacting with human basophils." Blood 69, no. 5 (1987): 1414–18. http://dx.doi.org/10.1182/blood.v69.5.1414.1414.

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Abstract Bsp-1 is an IgM murine monoclonal antibody raised against the human erythroblastic leukemia cell line (HEL) that reacts with basophils but not neutrophils or eosinophils. Western blotting techniques showed that Bsp-1 reacts with a 45-kilodalton surface antigen on HEL cells. The distribution of Bsp-1 antigen on leukemic cells is confined to a basophilic leukemia cell line, KU812, chronic myeloid leukemia with basophilia, and some cases of acute undifferentiated leukemia. Bsp-1 might therefore be a useful reagent for the study of basophil function and differentiation.

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5

Bodger, MP, GL Mounsey, J. Nelson, and PH Fitzgerald. "A monoclonal antibody reacting with human basophils." Blood 69, no. 5 (1987): 1414–18. http://dx.doi.org/10.1182/blood.v69.5.1414.bloodjournal6951414.

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Bsp-1 is an IgM murine monoclonal antibody raised against the human erythroblastic leukemia cell line (HEL) that reacts with basophils but not neutrophils or eosinophils. Western blotting techniques showed that Bsp-1 reacts with a 45-kilodalton surface antigen on HEL cells. The distribution of Bsp-1 antigen on leukemic cells is confined to a basophilic leukemia cell line, KU812, chronic myeloid leukemia with basophilia, and some cases of acute undifferentiated leukemia. Bsp-1 might therefore be a useful reagent for the study of basophil function and differentiation.

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6

Beauvillain, Céline, Martine Drouet, and Gilles Renier. "Le test d'activation des basophiles." Revue Francophone des Laboratoires 2008, no. 404 (2008): 67–77. http://dx.doi.org/10.1016/s1773-035x(08)71562-4.

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7

Varım, Ceyhun, Tezcan Kaya, Ahmet Nalbant, Ayşenur Uçar, and Ali Tamer. "Effects of Glucose Control on Hematological Indices in Patients with Diabetes Mellitus." Open Access Macedonian Journal of Medical Sciences 2, no. 1 (2014): 83–88. http://dx.doi.org/10.3889/oamjms.2014.015.

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Aim: We aimed to investigate the effects of diabetes treatment modalities on haematological parameters and leukocyte formula in patients with type 2 diabetes mellitus.Materials and Methods: The study included 102 patients with type 2 diabetes, out of which 51 receiving insulin treatment and 51 receiving oral antidiabetics (OAD). Hemogram data of insulin and OAD treated groups were compared.Results HbA1c levels were 11.12 ± 2.09 mg/dl in insulin group and 7.94 ± 2.1 mg/dl in OAD group p=0.001. Platelet counts were 27866.67 ± 77693 109/L before treatment and 258941.18 ± 69068.2 109/L in OAD grou

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8

Ponvert, C., and J. Paupe. "Les polynucléaires basophiles et les mastocytes." Revue Française d'Allergologie et d'Immunologie Clinique 33, no. 1 (1993): 55–68. http://dx.doi.org/10.1016/s0335-7457(05)80125-x.

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9

Tanaka, Yasuhiro, Atsushi Tanaka, Akiko Hashimoto, Kumiko Hayashi, and Isaku Shinzato. "Acute Myeloid Leukemia with Basophilic Differentiation Transformed from Myelodysplastic Syndrome." Case Reports in Hematology 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/4695491.

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Myelodysplastic syndrome (MDS) terminally transforms to acute myeloid leukemia (AML) or bone marrow failure syndrome, but acute myeloid leukemia with basophilic differentiation has been rarely reported. An 81-year-old man was referred to our department for further examination of intermittent fever and normocytic anemia during immunosuppressive treatment. Chromosomal analysis showed additional abnormalities involving chromosome 7. He was diagnosed as having MDS. At the time of diagnosis, basophils had not proliferated in the bone marrow. However, his anemia and thrombocytopenia rapidly worsened

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10

Prin, L. "Mastocytes, basophiles, éosinophiles Analyse des marqueurs biologiques." Revue Française d'Allergologie et d'Immunologie Clinique 36, no. 8 (1996): 889–96. http://dx.doi.org/10.1016/s0335-7457(96)80109-2.

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11

Tchen, John, and Nicolas Charles. "Les granulocytes basophiles et les IgE dans l’autoimmunité." médecine/sciences 38, no. 4 (2022): 366–73. http://dx.doi.org/10.1051/medsci/2022040.

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Comprendre les mécanismes physiopathologiques des maladies autoimmunes présentant des auto-anticorps (MAPA) représente un enjeu majeur pour le développement d’approches thérapeutiques innovantes. Sans en connaître précisément les origines, chez certains individus, la perte de tolérance à des antigènes du soi conduit à l’instauration d’une réaction en chaîne autoimmune. Des autoanticorps sont cependant présents dans une large proportion de la population générale sans être associés à une maladie. L’amplification de la production de ces autoanticorps, la formation de complexes immuns circulants e

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12

Galeotti, C., E. Stephen-Victor, M. Sharma, S. V. Kaveri, and J. Bayry. "Orientation de la réponse immune par les basophiles." Revue Française d'Allergologie 56, no. 3 (2016): 117–19. http://dx.doi.org/10.1016/j.reval.2016.01.025.

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13

Daëron, M. "Les récepteurs pour les anticorps des basophiles humains." Revue Française d'Allergologie 56, no. 3 (2016): 114–16. http://dx.doi.org/10.1016/j.reval.2016.01.038.

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14

Pieron, R., M. Grivaux, F. Lancastre, A. M. Deluol, and Y. Colin. "Test de dégranulation des basophiles humains et schistosomose." Médecine et Maladies Infectieuses 15, no. 4 (1985): 156–61. http://dx.doi.org/10.1016/s0399-077x(85)80270-5.

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15

Tait Wojno, Elia, Mario Noti, Brian Kim, et al. "Dissecting mechanisms underlying the pathogenesis of eosinophilic esophagitis (HYP6P.263)." Journal of Immunology 192, no. 1_Supplement (2014): 118.8. http://dx.doi.org/10.4049/jimmunol.192.supp.118.8.

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Abstract Eosinophilic esophagitis (EoE) is an allergic disease characterized by esophageal eosinophilia, inflammation, and dysfunction. EoE has become increasingly common, but current management strategies are nonspecific. Thus, there is an urgent need to identify new pathways that could be targeted to treat EoE. Recently, EoE was associated with a gain-of-function polymorphism in the gene that encodes thymic stromal lymphopoietin (TSLP), a cytokine that promotes allergic inflammation and peripheral basophilia. However, how TSLP and basophils might contribute to the development of eosinophil r

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16

Agis, Hermine, Maria T. Krauth, Leonhard Muellauer, Lawrence B. Schwartz, Hans P. Horny, and Peter Valent. "Enumeration and Immunologic Characterization of Basophils in Normal Bone Marrow and Patients with Myeloproliferative Disorders." Blood 104, no. 11 (2004): 4754. http://dx.doi.org/10.1182/blood.v104.11.4754.4754.

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Abstract Basophils are highly specialized granulocytes that express a unique profile of antigens and increase in myeloproliferative disorders. In chronic myeloid leukemia (CML), basophilia is an independent prognostic variable. So far, however, no reliable immunohistochemical approach for routine-detection and enumeration of bone marrow (bm) basophils has become available. To overcome this disadvantage, we have applied the anti-basophil antibody 2D7 on formalin-fixed, paraffin-embedded sections of normal bm and bm from patients (pts) with chronic myeloid leukemia (CML; chronic phase, n=21; acc

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17

Bjornsson, Sven, Saga Wahlstrom, Ingela Bernevi, and Per Simonsson. "A Single Tube Antibody Panel for Differential Count by Flow Cytometry." Blood 106, no. 11 (2005): 4938. http://dx.doi.org/10.1182/blood.v106.11.4938.4938.

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Abstract Introduction Several techniques are used for classification of leukocytes, i.e. microscopy, cell counters and flow cytometry. A skilled microscopist will classify at least 14 cell classes in bone marrow or blood. We have designed a one tube immunophenotyping panel for leukocyte classification and validated it against microscopy. Multiparameter flow cytometry provide at least seven measurements on each cell passing through the laser beam. Our goal was to use the seven parameters available in our flow cytometer to provide a reliable differential count using only one tube. Materials and

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18

Mukai, Kaori, Maya J. BenBarak, Masashi Tachibana, et al. "Critical role of P1-Runx1 in mouse basophil development." Blood 120, no. 1 (2012): 76–85. http://dx.doi.org/10.1182/blood-2011-12-399113.

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Abstract Runx1 P1N/P1N mice are deficient in the transcription factor distal promoter-derived Runt-related transcription factor 1 (P1-Runx1) and have a > 90% reduction in the numbers of basophils in the BM, spleen, and blood. In contrast, Runx1P1N/P1N mice have normal numbers of the other granulocytes (neutrophils and eosinophils). Although basophils and mast cells share some common features, Runx1P1N/P1N mice have normal numbers of mast cells in multiple tissues. Runx1P1N/P1N mice fail to develop a basophil-dependent reaction, IgE-mediated chronic allergic inflammation of the skin, but res

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19

Arock, M., H. Merle-Béral, B. Dugas, et al. "IL-4 release by human leukemic and activated normal basophils." Journal of Immunology 151, no. 3 (1993): 1441–47. http://dx.doi.org/10.4049/jimmunol.151.3.1441.

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Abstract Recently, authors have addressed the ability of human basophils to produce IL-4. We report here the detection of significant serum IL-4 levels in a case of acute transformation of chronic myelogenous leukemia with a predominant basophilic cell population. Leukemic basophils were isolated from patients' PBMC and assayed for their IL-4-mRNA expression and their ability to secrete this cytokine in vitro. Leukemic basophilic cells (&gt; 90% toluidine blue positive) but not other PBMC expressed IL-4-mRNA, contained IL-4 protein, and secreted this cytokine. These cells had a spontaneous

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20

Leynadier, F., J. Dry, A. Aidaoui, and M. Khellaf. "Dégranulation des basophiles humains après intervention dans l'hydatidose pulmonaire." Revue Française d'Allergologie et d'Immunologie Clinique 25, no. 1 (1985): 42. http://dx.doi.org/10.1016/s0335-7457(85)80032-0.

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21

Sadovnik, Irina, Daniel Ivanov, Dubravka Smiljkovic, et al. "Identification of CD203c as a New Basophil-Specific Flow-Marker in Ph+ Chronic Myeloid Leukemia." Cells 12, no. 1 (2022): 3. http://dx.doi.org/10.3390/cells12010003.

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Basophilia is a crucial prognostic variable in Ph-chromosome-positive chronic myeloid leukemia (CML). The ectoenzyme CD203c is an activation-linked surface antigen that is expressed specifically on basophil-committed progenitor cells and mature basophils. We examined the expression of CD203c on progenitors and/or basophils in 21 healthy donors and 44 patients with CML. As expected, the numbers of CD203c+ blood leukocytes were significantly higher in CML patients compared to controls (percentage of CD203c+ cells among viable cells in CML at diagnosis: 4.19 ± 3.68% vs. controls: 0.53 ± 0.23%, p

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22

Ohnmacht, Caspar, and David Voehringer. "Basophil effector function and homeostasis during helminth infection." Blood 113, no. 12 (2009): 2816–25. http://dx.doi.org/10.1182/blood-2008-05-154773.

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AbstractBasophils are effector cells of the innate immune system that are associated with allergic inflammation and infections with helminth parasites. However, their development and in vivo functions are largely unknown. Here, we characterize basophil development, turnover, tissue localization, and effector function during infection with the helminth Nippostrongylus brasiliensis. Our results demonstrate that under homeostatic conditions basophils have a lifespan of about 60 hours. N brasiliensis–induced basophilia is caused by increased de novo production of basophils in the bone marrow. Baso

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23

Smuda, Craig, Kavitha Rao, and Melissa Brown. "Ikaros regulates basophil and mast cell development and function (P4476)." Journal of Immunology 190, no. 1_Supplement (2013): 52.55. http://dx.doi.org/10.4049/jimmunol.190.supp.52.55.

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Abstract Mast cells and basophils are phenotypically similar but functionally distinct myeloid cells, originating from both common and distinct progenitors. Several transcription factors have been identified as important to development of these cells, but regulation of this process remains poorly understood. We have found Ikaros, a diversely spliced DNA-binding protein, to be critical to lineage selection in these cells. Ikaros-/- mice exhibit basophilia in peripheral blood and hematopoietic tissues and expansion of basophil progenitors. Mast cells and their precursors are absent in gut, thoug

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24

Daëron, M. "IgE et IgG, basophiles et neutrophiles : l’arbre et la forêt." Revue Française d'Allergologie 52, no. 3 (2012): 218–22. http://dx.doi.org/10.1016/j.reval.2012.01.018.

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25

Keykhosravi, S., A. Slama, R. Arif, et al. "Les nanoparticules fullerènes inhibent l’activation de basophiles de patients allergiques." Revue Française d'Allergologie 59, no. 3 (2019): 302–3. http://dx.doi.org/10.1016/j.reval.2019.02.180.

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26

Benhamou, M. "Antigènes de différenciation des mastocytes, basophiles et éosinophiles : mécanismes d'activation." Revue Française d'Allergologie et d'Immunologie Clinique 36, no. 8 (1996): 879–83. http://dx.doi.org/10.1016/s0335-7457(96)80107-9.

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27

Li, H., T. C. Sim, and R. Alam. "IL-13 released by and localized in human basophils." Journal of Immunology 156, no. 12 (1996): 4833–38. http://dx.doi.org/10.4049/jimmunol.156.12.4833.

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Abstract We and others have shown that human basophils can synthesize and release IL-4. However, IL-13, a cytokine that closely resembles IL-4, has not hitherto been described as a basophil product. The production of IL-13 by basophils was demonstrated by immunocytochemistry. Approximately 70% of basophils stimulated with anti-FcepsilonRIalpha (antibody to the alpha subunit of IgE receptor type I) stained for IL-13. Under similar experimental conditions, mononuclear cells failed to stain for IL-13. The cytokine was localized to basophilic granules by electron microscopic examination of immunog

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28

Halfon, M., G. Hanouna, B. Dema, et al. "Intérêt clinique des marqueurs d’activation des basophiles dans la néphropathie lupique." Néphrologie & Thérapeutique 15, no. 5 (2019): 279. http://dx.doi.org/10.1016/j.nephro.2019.07.043.

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29

Nalbantoglu, S., N. Oznur, M. F. Bozkurt, and S. A. Vural. "Histomonose bei Puten." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 36, no. 03 (2008): 209–12. http://dx.doi.org/10.1055/s-0038-1624037.

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Zusammenfassung: Gegenstand: Die Arbeit beschreibt das Krankheitsbild der Histomonose bei Puten. Material und Methode: Bei drei im Alter von 4 Monaten gestorbenen Tieren erfolgte eine pathologische und protozoologische Untersuchung, bei den überlebenden Puten wurden die klinischen Symptome erfasst. Ergebnisse: In vivo fielen bei den erkrankten Tieren vor allem Anorexie, Depression, Veränderung der allgemeinen Verhaltensweisen und ein abnehmendes Körpergewicht auf. Als Einzelsymptome ließen sich gesträubtes Gefieder, herabhängende Flügel, gesenkte Köpfe mit blau-violett verfärbten Kämmen und be

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30

Antohe, Ion, Angela Dăscălescu, Cătălin Dănăilă, et al. "FLT-3 ITD Positive Acute Basophilic Leukemia with Rare Complex Karyotype Presenting with Acute Respiratory Failure: Case Report." Revista Romana de Medicina de Laborator 26, no. 1 (2018): 87–94. http://dx.doi.org/10.1515/rrlm-2017-0036.

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Abstract Background: Acute basophilic leukemia is a rare subtype of acute myeloid leukemia, as categorized by the 2008 World Health Organization classification of myeloid neoplasms. Acute basophilic leukemia diagnosis requires thorough morphological, cytochemical, immunophenotypic, molecular, and cytogenetic studies and exclusion of other hematological neoplasms associating basophilia. The disease course is defined by histamine driven, occasionally life-threatening respiratory, cardiovascular, cutaneous or digestive complications, as well as primary refractoriness to standard therapy. Clinical

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31

Kudryavtseva, A. V. "The modern aspects of atopic dermatitis pathogenesis in children." Russian Journal of Allergy 7, no. 5 (2009): 48–57. http://dx.doi.org/10.36691/rja893.

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The article analyzes the results obtained by modern Russian and foreign researchers who focused on the pathogenic factors responsible for the appearance and the development of atopic dermatitis. The reasons for skin dryness appearance, the mechanisms of itch development, the immune system role in allergic skin inflammation: the involvement of lymphocytes, antigen presenting sells, mast cells, basophiles and eosinophiles into the pathological process have been thoroughly observed. The causes contributing to atopic dermatitis development and triggering disease aggravation have been described.

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32

Pellefigues, Christophe. "Les granulocytes basophiles sont sensibles à une grande diversité de stimulus innés." médecine/sciences 38, no. 1 (2022): 22–24. http://dx.doi.org/10.1051/medsci/2021229.

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33

Aubry, E., P. Nicaise, E. Amsler, et al. "Intérêt du Test d’Activation des Basophiles (TAB) dans l’Hypersensibilité Immédiate au Paracétamol." Revue Française d'Allergologie 61, no. 4 (2021): 274–75. http://dx.doi.org/10.1016/j.reval.2021.03.114.

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34

Leynadier, F., M. Murrieta, C. Garcia-Duarte, and J. Dry. "Evolution de la dégranulation des basophiles humains après désensibilisation accélérée aux pneumallergènes." Revue Française d'Allergologie et d'Immunologie Clinique 25, no. 2 (1985): 106–7. http://dx.doi.org/10.1016/s0335-7457(85)80049-6.

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35

Chaigne, B., V. Le Guern, T. A. Szwebel, et al. "Caractérisation phénotypique des perturbations périphériques des basophiles dans le syndrome des antiphospholipides." La Revue de Médecine Interne 38 (December 2017): A48—A49. http://dx.doi.org/10.1016/j.revmed.2017.10.318.

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36

Zamfir-Chiru-Anton, Adina, and Dan-Cristian Gheorghe. "Potential markers for allergic rhinitis evaluation." Romanian Medical Journal 63, no. 1 (2016): 17–19. http://dx.doi.org/10.37897/rmj.2016.1.4.

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Allergic rhinitis is the result of a permanent/intermitent inflammation of the nasal mucosa, exposed to certain alergens. An immunological reaction is the fundamental cause – a type I hypersensitivity reaction, followed by local inflammatory response and immune cell pooling (eosinophiles, basophiles, Th cells, mast cells) in the nasal mucosa. Matrix metaloproteinases are tissue proteases that degrade extracellular matrix and basilar membrane and modulate immune responses. Our article reviews the part metalloproteinases play in the changes suffered by the nasal mucosa in chronic allergic rhinit

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37

Nicaise-Roland, P., M. Laugel, F. Jaballah, et al. "Place du test d’activation des basophiles dans l’initiation de l’immunothérapie aux venins d’hyménoptères." Revue Française d'Allergologie 58, no. 3 (2018): 231–32. http://dx.doi.org/10.1016/j.reval.2018.02.022.

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Abuaf, N., N. Rajoely, C. Pecquet, and F. Leynadier. "Les myorelaxants (MR) à forte concentration activent les basophiles des sujets non allergiques." Revue Française d'Allergologie et d'Immunologie Clinique 41, no. 1 (2001): 132. http://dx.doi.org/10.1016/s0335-7457(01)80081-2.

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Hirai, K., M. Yamaguchi, Y. Misaki, et al. "Enhancement of human basophil histamine release by interleukin 5." Journal of Experimental Medicine 172, no. 5 (1990): 1525–28. http://dx.doi.org/10.1084/jem.172.5.1525.

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Substantial evidence indicates a close relationship between eosinophils and basophils. We examined whether interleukin 5 (IL-5), known to be eosinophilopoietic and capable of selectively regulating eosinophil functions, has an affect on basophil functions. IL-5 enhanced basophil histamine release evoked by anti-IgE, formyl-methionyl-leucyl-phenylalanine, or ionophore A23187 at picomolar concentrations. Direct action of IL-5 on human basophils was confirmed using highly purified basophil populations. These observations reveal the novel fact that IL-5 is able to modulate basophil functions as we

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Bax, Heather J., Jitesh Chauhan, Chara Stavraka, et al. "Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome." Cells 9, no. 7 (2020): 1631. http://dx.doi.org/10.3390/cells9071631.

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Basophils are involved in manifestations of hypersensitivity, however, the current understanding of their propensity for activation and their prognostic value in cancer patients remains unclear. As in healthy and atopic individuals, basophil populations were identified in blood from ovarian cancer patients (n = 53) with diverse tumor histologies and treatment histories. Ex vivo basophil activation was measured by CD63 expression using the basophil activation test (BAT). Irrespective of prior treatment, basophils could be activated by stimulation with IgE- (anti-FcεRI and anti-IgE) and non-IgE

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41

Kepley, C. L., S. S. Craig, and L. B. Schwartz. "Identification and partial characterization of a unique marker for human basophils." Journal of Immunology 154, no. 12 (1995): 6548–55. http://dx.doi.org/10.4049/jimmunol.154.12.6548.

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Abstract A unique marker for human basophils is needed to precisely determine the involvement of this cell type in clinical disease. To search for a marker of the basophil secretory granule, mouse hybridomas were generated against purified human basophils and screened for basophil-selective Ab. One hybridoma (2D7) produced an IgG1 kappa Ab that labeled basophils, but not lymphocytes, monocytes, eosinophils, neutrophils, and mast cells by an indirect immunoperoxidase procedure. The pattern of basophil staining was cytoplasmic and granular by light microscopy. By immunogold electron microscopy,

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42

Iikura, Motoyasu, Masao Yamaguchi, Takao Fujisawa, et al. "Secretory IgA Induces Degranulation of IL-3-Primed Basophils." Journal of Immunology 161, no. 3 (1998): 1510–15. http://dx.doi.org/10.4049/jimmunol.161.3.1510.

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Abstract We examined whether secretory IgA (sIgA), known to mediate eosinophil stimulation, has an effect on basophil functions. An immobilized preparation of sIgA, but not of monomeric IgA, induced histamine release (approximately 15% of total histamine contents) from human basophils in vitro. sIgA-induced basophil histamine release was totally dependent on pretreatment with IL-3. IL-5 and granulocyte-macrophage CSF also primed basophils for sIgA-mediated release. Exogenous divalent ions, i.e., Ca2+ and Mg2+, were essential for sIgA-mediated basophil degranulation, and the degranulation was c

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43

Bochner, B. S., D. W. MacGlashan, G. V. Marcotte, and R. P. Schleimer. "IgE-dependent regulation of human basophil adherence to vascular endothelium." Journal of Immunology 142, no. 9 (1989): 3180–86. http://dx.doi.org/10.4049/jimmunol.142.9.3180.

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Abstract Mechanisms favoring the recruitment of circulating human basophils to extravascular sites of allergic inflammation are unknown. The basophil secretagogues anti-IgE, and pollen allergens rye grass I and ragweed Ag E (Lol p I and Amb a I) were tested for their ability to promote basophil adherence to umbilical vein endothelial cells. Co-incubation of endothelial cells and basophils with anti-IgE resulted in time and dose-dependent increases in basophil adhesion. These effects were due to activation of the basophil, required both magnesium and calcium, occurred before or in the absence o

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44

Asiryn, Elena, Pavel Novikov, Volha Matsiushchanka, Nadiezhda Titova, Lukas Vaidelys, and Greta Griciūnaitė. "THE EFFECT OF MAGNETO-LASER THERAPY ON THE PHENOTYPE OF BASOPHILS IN CHILDREN WITH ATOPIC ASTHMA." Visuomenės sveikata 29, no. 2 (2019): 35–38. http://dx.doi.org/10.5200/sm-hs.2018.014.

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In recent years there has been growing evidence to suggest a major role of basophils alongside eosinophils and mast cells in allergic inflammation. The aim of this study was to analyze the dynamics of the basophil phenotypes after the use of magneto-la-ser therapy in children with atopic bronchial asthma. Materials and methods. A total of 66 children with mild persistent atopic bronchial asthma (aged 6 to 18 years old) were examined. Group A included 34 children who received magneto-laser therapy together with basic asthma treatment (low dose of inhaled corticosteroids). Group B included 32 ch

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Asiryn, Elena, Pavel Novikov, Volha Matsiushchanka, Nadiezhda Titova, Lukas Vaidelys, and Greta Griciūnaitė. "THE EFFECT OF MAGNETO-LASER THERAPY ON THE PHENOTYPE OF BASOPHILS IN CHILDREN WITH ATOPIC ASTHMA." Visuomenės sveikata 29, no. 2 (2019): 35–38. http://dx.doi.org/10.5200/sm-hs.2019.014.

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In recent years there has been growing evidence to suggest a major role of basophils alongside eosinophils and mast cells in allergic inflammation. The aim of this study was to analyze the dynamics of the basophil phenotypes after the use of magneto-la-ser therapy in children with atopic bronchial asthma. Materials and methods. A total of 66 children with mild persistent atopic bronchial asthma (aged 6 to 18 years old) were examined. Group A included 34 children who received magneto-laser therapy together with basic asthma treatment (low dose of inhaled corticosteroids). Group B included 32 ch

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Debleds, Véronique, and Cédric Lagarde. "Mesure par cytométrie en flux de l'activation in vitro des basophiles par des allergènes." Revue Française des Laboratoires 2005, no. 370 (2005): 57–60. http://dx.doi.org/10.1016/s0338-9898(05)80038-1.

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Luyasu, S., N. Hougardy, F. Hasdenteufel, E. Weber, and G. Kanny. "Anaphylaxie à l’insuline humaine recombinante : monitoring de la désensibilisation par tests d’activation des basophiles." La Revue de Médecine Interne 29 (June 2008): S126. http://dx.doi.org/10.1016/j.revmed.2008.03.230.

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Sullivan, Brandon, Hong-Erh Liang, Jennifer Bando, et al. "Genetic analysis of basophil function in vivo (151.22)." Journal of Immunology 186, no. 1_Supplement (2011): 151.22. http://dx.doi.org/10.4049/jimmunol.186.supp.151.22.

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Abstract Contributions by basophils to allergic and helminth immunity remain controversial. Using sensitive IL-4 reporter alleles, we demonstrate that basophil IL-4 production occurs by a CD4 T cell-dependent process restricted to affected peripheral tissues. We genetically marked and specifically deleted basophils and demonstrate that basophils do not mediate Th2 priming in vivo. Two-photon imaging confirmed that basophils do not interact with antigen-specific T cells in lymph nodes, but can engage in prolonged serial interactions with T cells in lung tissues. Although targeted deletion of IL

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Piliponsky, Adrian Martin, Nicholas J. Shubin, Asha Lahiri, et al. "Basophil-derived tumor necrosis factor can enhance immune responses in a sepsis model in mice." Journal of Immunology 202, no. 1_Supplement (2019): 126.2. http://dx.doi.org/10.4049/jimmunol.202.supp.126.2.

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Abstract Basophils are evolutionarily conserved in vertebrates, despite their small numbers and short lifespan, suggesting that basophils have beneficial roles in maintaining health. However, these roles are not fully defined. Here, we demonstrate that basophil-deficient mice exhibited reduced bacterial clearance, and increased morbidity and mortality, in the cecal ligation and puncture (CLP) model of sepsis. Among the several pro-inflammatory mediators we measured, tumor necrosis factor (TNF) was the only cytokine that was significantly reduced in basophil-deficient mice after CLP. TNF is cri

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Bischoff, S. C., T. Brunner, A. L. De Weck, and C. A. Dahinden. "Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists." Journal of Experimental Medicine 172, no. 6 (1990): 1577–82. http://dx.doi.org/10.1084/jem.172.6.1577.

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Human interleukin 5 (IL-5), known as a selective colony-stimulating factor of the eosinophil lineage and activator of mature eosinophils, also profoundly influences the mediator release profile of human basophils. IL-5 by itself triggers neither granule release nor de novo synthesis of lipid mediators. However, at low concentrations (0.1-10 ng/ml), IL-5 rapidly primes basophils for enhanced histamine release and leukotriene C4 (LTC4) generation in response to all established basophil agonists. LTC4 generation is more strongly affected by IL-5 than histamine release. In particular, IL-5 renders

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