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Journal articles on the topic 'Batch Manufacturing process'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Burcham, Christopher L., Alastair J. Florence, and Martin D. Johnson. "Continuous Manufacturing in Pharmaceutical Process Development and Manufacturing." Annual Review of Chemical and Biomolecular Engineering 9, no. 1 (2018): 253–81. http://dx.doi.org/10.1146/annurev-chembioeng-060817-084355.

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The pharmaceutical industry has found new applications for the use of continuous processing for the manufacture of new therapies currently in development. The transformation has been encouraged by regulatory bodies as well as driven by cost reduction, decreased development cycles, access to new chemistries not practical in batch, improved safety, flexible manufacturing platforms, and improved product quality assurance. The transformation from batch to continuous manufacturing processing is the focus of this review. The review is limited to small, chemically synthesized organic molecules and en

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2

Xie, Xiangzhong, and René Schenkendorf. "Robust Process Design in Pharmaceutical Manufacturing under Batch-to-Batch Variation." Processes 7, no. 8 (2019): 509. http://dx.doi.org/10.3390/pr7080509.

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Model-based concepts have been proven to be beneficial in pharmaceutical manufacturing, thus contributing to low costs and high quality standards. However, model parameters are derived from imperfect, noisy measurement data, which result in uncertain parameter estimates and sub-optimal process design concepts. In the last two decades, various methods have been proposed for dealing with parameter uncertainties in model-based process design. Most concepts for robustification, however, ignore the batch-to-batch variations that are common in pharmaceutical manufacturing processes. In this work, a

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3

Gao, Ruiyan. "The transition from batch to continuous manufacturing for tablet manufacturing performance comparison and control system review." Applied and Computational Engineering 7, no. 1 (2023): 685–91. http://dx.doi.org/10.54254/2755-2721/7/20230314.

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The pharmaceutical industry is motivated to improve tablet productivity in order to adapt to the expanding drug market. One innovative way is the transition of the traditional batch tablet manufacturing process to a continuous process. This paper aims to review the performance of continuous tablet manufacturing processes. From the comparison of continuous to traditional batch processes, the continuous tablet manufacturing process demonstrates improvements in production flexibility, robustness, and ultimately process profitability. The continuous process is proven to mix drug particles with mor

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4

Stephanopoulos, George, Shahin Ali, Andreas Linninger, and Enrique Salomone. "Batch process development: From reactions to manufacturing systems." Computers & Chemical Engineering 23 (June 1999): S975—S984. http://dx.doi.org/10.1016/s0098-1354(99)80232-4.

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5

Yue, Ming Yue, and Yi Dan Zhou. "Progress of Theoretical Research-Oriented Multi-Species Small Batch Machining Process." Applied Mechanics and Materials 364 (August 2013): 470–73. http://dx.doi.org/10.4028/www.scientific.net/amm.364.470.

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With the rapid development of machinery manufacturing industry, multi variety and small batch production has gradually become one of the main means of manufacturing enterprises. On the basis of describing the characteristics and meaning of multi variety and small batch production, this article summarizes its domestic and international situation of machinery process theory, optimization and evaluation methods, presents several methods of mathematical description and model for multi variety and small batch production and finally summarize the trends of matching problem between the processing tec

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6

James, D. "Batch process automation." Manufacturing Engineer 85, no. 6 (2006): 36–41. http://dx.doi.org/10.1049/me:20060604.

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7

Yu, Zhonghua. "ALGORITHM OF QUALITY CONTROL IN SMALL BATCH MANUFACTURING PROCESS." Chinese Journal of Mechanical Engineering 37, no. 08 (2001): 60. http://dx.doi.org/10.3901/jme.2001.08.060.

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8

Braglia, Marcello, Roberto Gabbrielli, and Francesco Zammori. "Consignment stock theory with a fixed batch manufacturing process." International Journal of Production Research 51, no. 8 (2013): 2377–98. http://dx.doi.org/10.1080/00207543.2012.740577.

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9

Kim, Yong-Jae, and Byung-Soo Kim. "Population-Based Meta-Heuristic Algorithms for Integrated Batch Manufacturing and Delivery Scheduling Problem." Mathematics 10, no. 21 (2022): 4127. http://dx.doi.org/10.3390/math10214127.

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This paper addresses an integrated scheduling problem of batch manufacturing and delivery processes with a single batch machine and direct-shipping trucks. In the manufacturing process, some jobs in the same family are simultaneously processed as a production batch in a single machine. The batch production time depends only on the family type assigned to the production batch and it is dynamically adjusted by batch deterioration and rate-modifying activities. Each job after the batch manufacturing is reassigned to delivery batches. In the delivery process, each delivery batch is directly shippe

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10

Taga (Sapunaru), Olga Valerica, Claudia Irina Koncsag, Cosmin Jinescu, and Alina Monica Mares. "Simulation and Optimization of Isopropyl Lactate Manufacturing Process." Revista de Chimie 70, no. 9 (2019): 3335–37. http://dx.doi.org/10.37358/rc.19.9.7544.

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The new chemical processes are investigated in laboratory, usually in batch, with pure reactants, and specific laboratory methods applied for the purification of the products. Scaling-up processes means passing from batch to continuous process, using feed with impurificators, industrial equipment for separation and recirculation or purge for an economic operation with special care for safety and environment. This is why, following a study in laboratory for isopropyl lactate obtaining by transesterification in reactive distillation system, a flowsheet of the industrial process was proposed in t

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Yuan, Hong Liang, Ai Min Wang, and Jin Fan Lei. "Job-Shop Manufacturing Execution Process Monitoring Technology." Advanced Materials Research 421 (December 2011): 483–88. http://dx.doi.org/10.4028/www.scientific.net/amr.421.483.

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According to the production characteristics of single piece and small batch production and the combination of production and research in aerospace workshops, this thesis has made an in-depth study of job-shop manufacturing execution process monitoring technology with strong adaptability. A model for visual manufacturing process monitoring based on process route was proposed, it realizes the job-shop production featured by entire staff participation, entire process management and omnibearing warranty.

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12

Kush, Upadhyay, P. Singh H, and Goyal Anju. "Process Validation of Bempedoic Acid Film-Coated Tablets." Chemistry Research Journal 6, no. 5 (2021): 1–11. https://doi.org/10.5281/zenodo.11759299.

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<strong>Abstract </strong>Process validation is establishing documented evidence which provides a high degree of assurance that a specified process will consistently produce a product meeting its predetermined specifications and quality characteristics. Bempedoic acid is used as an active pharmaceutical ingredient. Other raw materials used are: Microcrystalline cellulose, Lactose monohydrate, Sodium starch glycolate, Hydroxypropyl cellulose, Colloidal silicon dioxide and purified water. Process validation was done to reduce variation between various batches, to decrease the risk of defect cost

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13

Liu, Yujun, Dong Ni, and Zongyi Wang. "A Fault-Tolerant Soft Sensor Algorithm Based on Long Short-Term Memory Network for Uneven Batch Process." Processes 12, no. 3 (2024): 495. http://dx.doi.org/10.3390/pr12030495.

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Batch processing is a widely utilized technique in the manufacturing of high-value products. Traditional methods for quality assessment in batch processes often lead to productivity and yield losses because of offline measurement of quality variables. The use of soft sensors enhances product quality and increases production efficiency. However, due to the uneven batch data, the variation in processing times presents a significant challenge for building effective soft sensor models. Moreover, sensor failures, exacerbated by the manufacturing environment, complicate the accurate modeling of proc

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14

Lutz, Benjamin, Philip Howell, Daniel Regulin, Bastian Engelmann, and Jörg Franke. "Towards Material-Batch-Aware Tool Condition Monitoring." Journal of Manufacturing and Materials Processing 5, no. 4 (2021): 103. http://dx.doi.org/10.3390/jmmp5040103.

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In subtractive manufacturing, process monitoring systems are used to observe the manufacturing process, to predict maintenance actions and to suggest process optimizations. One challenge, however, is that the observable signals are influenced not only by the degradation of the cutting tool, but also by deviations in machinability among material batches. Thus it is necessary to first predict the respective material batch before making maintenance decisions. In this study, an approach is shown for batch-aware tool condition monitoring using feature extraction and unsupervised learning to analyze

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15

Forster, Seth P., Erin Dippold, Abbe Haser, Daniel Emanuele, and Robin Meier. "Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing." Pharmaceutics 15, no. 9 (2023): 2317. http://dx.doi.org/10.3390/pharmaceutics15092317.

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The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process. Compared with other oral solid dosage processes, wet granulation has been challenging to move towards continuous processing since traditional equipment has been predominantly strictly batch, instead of readily adapted to material flow such as dry granulation or tablet compression, and there have been few equipment options for continuous granule drying. Recently, pilot and

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De Vin, L. J., J. De Vries, and Ton Streppel. "Process planning for small batch manufacturing of sheet metal parts." International Journal of Production Research 38, no. 17 (2000): 4273–83. http://dx.doi.org/10.1080/00207540050205082.

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17

Li, Z. P. "Management Decisions in Multi-Variety Small-Batch Product Manufacturing Process." International Journal of Simulation Modelling 21, no. 3 (2022): 537–47. http://dx.doi.org/10.2507/ijsimm21-3-co15.

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18

Last, Mark, Guy Danon, Sholomo Biderman, and Eli Miron. "Optimizing a batch manufacturing process through interpretable data mining models." Journal of Intelligent Manufacturing 20, no. 5 (2008): 523–34. http://dx.doi.org/10.1007/s10845-008-0148-7.

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19

Singhal, S., B. Elkhatib, J. Stuber, S. V. Sreenivasan, and O. A. Ezekoye. "Characterization of Wet Batch Cleaning Process in Advanced Semiconductor Manufacturing." IEEE Transactions on Semiconductor Manufacturing 22, no. 3 (2009): 399–408. http://dx.doi.org/10.1109/tsm.2009.2026321.

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20

Yadav, Vikramaditya G. "Keeping it simple: A higher-yielding process for manufacturing dendritic cells." Science Translational Medicine 11, no. 517 (2019): eaaz9749. http://dx.doi.org/10.1126/scitranslmed.aaz9749.

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21

OȚEL, Călin Ciprian. "STUDY ON THE USE OF A METHOD FOR DETERMINING AGGREGATE LOT SIZE IN FLEXIBLE MANUFACTURING SYSTEMS WITH A VIEW TO REDUCING MANUFACTURING COSTS." Review of Management and Economic Engineering 24, no. 1 (2025): 23–31. https://doi.org/10.71235/rmee.194.

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The paper deals with the notion of aggregate batch used in flexible manufacturing systems and presents the way in which the size of the preparation-completion costs that occur when the flexible manufacturing system has to pass from one processing state to another, in order to process the parts included in the batch, vary according to the size of the aggregated batch. The affinity coefficient was used to express the size of the setup cost.

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22

Tao, Li Yan, Man Zhang, and Zu Da Li. "Study on the Product Quality Control in Small Batch Trial Process." Advanced Materials Research 694-697 (May 2013): 3507–11. http://dx.doi.org/10.4028/www.scientific.net/amr.694-697.3507.

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An Analytic Hierarchy Process (AHP) method was used to determine the key process in small batch trial process. Combining with the historical data of the key process in the product manufacturing process, similarity theory and data transformation methods, the data capacity relating to the product quality characteristics were enlarged. Through drawing a control chart of the process, the quality control in small batch trial process was realized.

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23

Kamel, Khaled, and Eman Kamel. "PLC Batch Process Control Design and Implementation Fundamentals." September 2020 2, no. 3 (2020): 155–61. http://dx.doi.org/10.36548/jei.2020.3.001.

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Batch process control is typically used for repeated chemical reaction tasks. It starts with a measured liquid material filling operations followed by a controlled reaction leading to the discharge or transport of processed quantities of material. The input materials is contained in vessel reactor and subjected to a sequence of processing activities over a recipe predefined duration of time. Batch systems are designed to measure, process, and discharge a varying volume of liquid from drums, tanks, reactors, or other large storage vessel using a programmable logic controller (PLC). These system

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24

Schmidt, Benedikt, Ruomu Tan, Nuo Li, Martin Hollender, and Marco Gärtler. "Efficient Process for Batch Analysis." Chemie Ingenieur Technik 93, no. 12 (2021): 1955–67. http://dx.doi.org/10.1002/cite.202100081.

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25

He, Fa Jiang, Ming Hong Wang, and Yue Wang. "Study of Statistical Process Control for Multi Specification and Small Batch Production Based on Group Technology." Advanced Materials Research 219-220 (March 2011): 713–17. http://dx.doi.org/10.4028/www.scientific.net/amr.219-220.713.

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For the multi specification and small batch productions, because of small batch and short manufacture cycle of product, it is difficulty to get enough sample data used for setup control chart to Statistical Process Control (SPC) of manufacture process quality by traditional SPC method. A new part code system based on OPTIZ code system is proposed by coding parts, manufacturing processes and qualities according to Group Technology (GT) based on similarity theory, so characteristics of parts, manufacturing processes and qualities are transformed to code, analyzed and judged by similarity theory

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26

Mahé, Amélie, Alexandra Martiné, Séverine Fagète, and Pierre-Alain Girod. "Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production." Bioprocess and Biosystems Engineering 45, no. 2 (2021): 297–307. http://dx.doi.org/10.1007/s00449-021-02657-w.

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AbstractIn the field of therapeutic antibody production, diversification of fed-batch strategies is flourishing in response to the market demand. All manufacturing approaches tend to follow the generally accepted dogma of increasing titer since it directly increases manufacturing output. While titer is influenced by the biomass (expressed as IVCD), the culture time and the cell-specific productivity (qP), we changed independently each of these parameters to tune our process strategy towards adapted solutions to individual manufacturing needs. To do so, we worked separately on the increase of t

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27

Schmidt, Axel, Heribert Helgers, Florian Lukas Vetter, Steffen Zobel-Roos, Alina Hengelbrock, and Jochen Strube. "Process Automation and Control Strategy by Quality-by-Design in Total Continuous mRNA Manufacturing Platforms." Processes 10, no. 9 (2022): 1783. http://dx.doi.org/10.3390/pr10091783.

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Vaccine supply has a bottleneck in manufacturing capacity due to operation personnel and chemicals needed. Assessment of existing mRNA (messenger ribonucleic acid) vaccine processing show needs for continuous manufacturing processes. This is enabled by strict application of the regulatory demanded quality by design process based on digital twins, process analytical technology, and control automation strategies in order to improve process transfer for manufacturing capacity, reduction out-of-specification batch failures, qualified personnel training and number, optimal utilization of buffers an

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28

Terzea, Elena Loredana, Antonia Cristina Barascu, and Iulian Razvan Soare. "Lean Solutions in Batch Manufacturing Process with Applicability in Bumpers Production." Applied Mechanics and Materials 834 (April 2016): 205–10. http://dx.doi.org/10.4028/www.scientific.net/amm.834.205.

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Batch processes includes paint manufacturing, food processing, pharmaceutical industry, etc. The paper focuses on the process of paint manufacturing. The main contribution is the design of the current value stream mapping, very useful to understand the causes of waste and lead-time. This paper points out the necessity of applying lean methods within automotive industry, sector of bumpers painting and assembly, based on a real case-study.

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29

Mendes, João P., Magnus Bergman, Anita Solbrand, Cristina Peixoto, Manuel J. T. Carrondo, and Ricardo J. S. Silva. "Continuous Affinity Purification of Adeno-Associated Virus Using Periodic Counter-Current Chromatography." Pharmaceutics 14, no. 7 (2022): 1346. http://dx.doi.org/10.3390/pharmaceutics14071346.

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Replacing batch unit operations of biopharmaceuticals by continuous manufacturing is a maturing concept, with periodic counter-current chromatography (PCC) favoured to replace batch chromatography. Continuous affinity capture of adeno-associated virus (AAV) using PCC has the potential to cope with the high doses required for AAV therapies thanks to its inherent high throughput. The implementation of continuous AAV affinity capture using a four-column PCC process is described herein. First, elution buffer screening was used to optimize virus recovery. Second, breakthrough curves were generated

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Helgers, Heribert, Axel Schmidt, Lara Julia Lohmann, et al. "Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody Manufacturing." Processes 9, no. 1 (2021): 172. http://dx.doi.org/10.3390/pr9010172.

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Continuous manufacturing opens up new operation windows with improved product quality in contrast to documented lot deviations in batch or fed-batch operations. A more sophisticated process control strategy is needed to adjust operation parameters and keep product quality constant during long-term operations. In the present study, the applicability of a combination of spectroscopic methods was evaluated to enable Advanced Process Control (APC) in continuous manufacturing by Process Analytical Technology (PAT). In upstream processing (USP) and aqueous two-phase extraction (ATPE), Raman-, Fourie

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31

Pinto, Caroline Barroso dos Anjos, Uwe Schwarzenbolz, Thomas Henle, Alan Frederick Wolfschoon-Pombo, Ítalo Tuler Perrone, and Rodrigo Stephani. "Doce de Leite Production: An Overview of the Different Industrial Production Technologies." Dairy 6, no. 2 (2025): 10. https://doi.org/10.3390/dairy6020010.

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Doce de leite is a caramel-like confection, mainly produced in several Latin American countries, with increasing popularity worldwide. This overview outlines nine distinct industrial technologies for the production of doce de leite: (1) total batch manufacturing process; (2) batch manufacturing system with fractionated mix addition; (3) manufacturing with pre-concentration in a vacuum evaporator and finishing in an open pan; (4) manufacturing with pre-concentration in a vacuum evaporator, finishing in an open pan, and lactose micro-crystallization; (5) continuous flow manufacturing with total

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32

Morris, Raymond A., and Edward F. Watson. "DETERMINING PROCESS CAPABILITY IN A CHEMICAL BATCH PROCESS." Quality Engineering 10, no. 2 (1997): 389–96. http://dx.doi.org/10.1080/08982119708919147.

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33

Oliva, Alexis, Magdalena Echezarreta, Álvaro Santana-Mayor, et al. "Assessing Protein Content and Dimer Formation in the Bevacizumab Reference Product and Biosimilar Versions Marketed in Spain." Pharmaceutics 16, no. 12 (2024): 1520. http://dx.doi.org/10.3390/pharmaceutics16121520.

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Background: The manufacture of biologics is a complex, controlled, and reproducible process that results in a product that meets specifications. This should be based on data from batches used to demonstrate manufacturing consistency. Ten batches of originator product (Avastin®) were analyzed over a 10-year period. Methods: The β-expectation tolerance intervals and the process capability analysis were proposed to establish the specification limits for determining the acceptance criteria of the final product from the manufacturing process. Protein concentration and dimer content were utilized as

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34

Renbi, Abdelghani, Johan Carlson, and Jerker Delsing. "Impact of PCB Manufacturing Process Variations on Trace Impedance." International Symposium on Microelectronics 2011, no. 1 (2011): 000891–95. http://dx.doi.org/10.4071/isom-2011-tha1-paper3.

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This paper demonstrates statistically the impact of PCB manufacturing variations on the characteristic impedance. Moreover, it shows that the characteristics of the PCBs vary across different suppliers. These differences cannot be tolerated in some applications where the characteristic impedance is restricted to be within a specific range. We sampled 3 × 20 PCBs, each batch of twenty is ordered from a different manufacturer. The sampling consist of measuring the phase shift between the reected and the incident signals when injecting a 180 MHz sinewave into a PCB trace. The trace is selected to

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Mihok, Jozef, Jaroslava Kádárová, Michal Demečko, and Martin Ružinský. "The Use of SMED in Engineering Manufacturing." Applied Mechanics and Materials 816 (November 2015): 568–73. http://dx.doi.org/10.4028/www.scientific.net/amm.816.568.

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To survive in such an increasingly competitive world, there is a need of continuous improvement in every type of industry. An answer to these challenges for manufacturing companies is the implementation of lean concepts. The importance of short changeover times, SMED, has always been critical for manufacturing companies. It is one of the many lean production methods for reducing waste in the manufacturing process. It's a quick and effective way adjustment process of the actual product to another product. The practical part is focused on usage of SMED in manufacturing. Project was realized in e

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Uhlenbrock, Lukas, Christoph Jensch, Martin Tegtmeier, and Jochen Strube. "Digital Twin for Extraction Process Design and Operation." Processes 8, no. 7 (2020): 866. http://dx.doi.org/10.3390/pr8070866.

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Traditional extraction processes of natural product are widespread, especially in regulated industries. Possibilities of extraction development and manufacturing optimization in regulated industries is limited. Regulatory approvals are often based on traditional preparations of phyto-pharmaceuticals. The dependence on traditional processes can result in sub-optimal extraction parameters causing unnecessary costs and product variability. Innovative methods like Quality-by-Design (QbD), including process analytical technology (PAT), open opportunities for manufacturers to cope with regulatory de

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Feng, An Ping. "Application Research of Numerical Control Machining Technology in Mechanical Manufacturing." Advanced Materials Research 898 (February 2014): 521–24. http://dx.doi.org/10.4028/www.scientific.net/amr.898.521.

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Mold manufacturing is an important part in mechanical manufacturing, and casting quality of mechanical manufacturing is influenced by mold quality directly. If mold manufacturing still adopts the traditional mode, that will has a severe dependence on core box or appearance, often with a relatively long period and relatively high cost, which will be hard to satisfy the rapid development and manufacturing of small batch sheet parts. This article introduces the application of new product development, processing equipment performance and process principle of metal parts no-mode numerical control p

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38

Bostijn, N., W. Dhondt, C. Vervaet, and T. De Beer. "PAT-based batch statistical process control of a manufacturing process for a pharmaceutical ointment." European Journal of Pharmaceutical Sciences 136 (August 2019): 104946. http://dx.doi.org/10.1016/j.ejps.2019.05.024.

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Hu, Chuntian, Christopher J. Testa, Stephen C. Born, et al. "E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals." Green Chemistry 22, no. 13 (2020): 4350–56. http://dx.doi.org/10.1039/d0gc01397h.

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Gros, Sebastien. "Dual-Mode Batch-to-Batch Optimization as a Markov Decision Process." Industrial & Engineering Chemistry Research 58, no. 30 (2019): 13780–91. http://dx.doi.org/10.1021/acs.iecr.8b06471.

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Frade, Verônica M. F., Attilio Converti, Saleh Al Arni, Milena F. Silva, and Mauri S. A. Palma. "Batch and Fed-Batch Degradation of Enrofloxacin by the Fenton Process." Chemical Engineering & Technology 40, no. 4 (2017): 663–69. http://dx.doi.org/10.1002/ceat.201600146.

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Milutinović, Mladomir, Dejan Movrin, Miloš Pjević, and Mihajlo Popović. "Additive Manufacturing." Tehnički glasnik 19, Si1 (2025): 141–46. https://doi.org/10.31803/tg-20250319152036.

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The increasing demand for custom-made products, small-batch production, and improved process efficiency is driving manufacturers to adopt advanced strategies that minimize costs and production time. Additive manufacturing (AM) technologies address these challenges by enabling rapid prototyping, design flexibility, and advanced tooling capabilities. Initially constrained to polymeric prototypes, AM now supports a diverse material range, including metals and temperature-resistant polymers. Injection molding is a widely used manufacturing process for producing plastic parts with high precision an

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Schmidt, Axel, Heribert Helgers, Florian Lukas Vetter, Alex Juckers, and Jochen Strube. "Fast and Flexible mRNA Vaccine Manufacturing as a Solution to Pandemic Situations by Adopting Chemical Engineering Good Practice—Continuous Autonomous Operation in Stainless Steel Equipment Concepts." Processes 9, no. 11 (2021): 1874. http://dx.doi.org/10.3390/pr9111874.

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SARS-COVID-19 vaccine supply for the total worldwide population has a bottleneck in manufacturing capacity. Assessment of existing messenger ribonucleic acid (mRNA) vaccine processing shows a need for digital twins enabled by process analytical technology approaches in order to improve process transfer for manufacturing capacity multiplication, a reduction in out-of-specification batch failures, qualified personal training for faster validation and efficient operation, optimal utilization of scarce buffers and chemicals and speed-up of product release by continuous manufacturing. In this work,

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44

Gong, Ke, Handai Liu, Cheng Huang, et al. "Mass Customization of Polylactic Acid (PLA) Parts via a Hybrid Manufacturing Process." Polymers 14, no. 24 (2022): 5413. http://dx.doi.org/10.3390/polym14245413.

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Mass customization is the development of items tailored to specific customers, but produced at low unit cost in high-volume. In this context, hybrid manufacturing (HM) combines fused deposition modeling (FDM) and injection molding (IM) to fabricate a single personalized part with minimum manufacturing cost. In this technique, inserts with different physical features are first FDM-fabricated and then IM-overmolded. This study investigated the effect of hybrid FDM-IM production technology, FDM insert geometry on mechanical properties, and micro-structural evolution of Polylactic Acid (PLA) sampl

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Gu, Shaowu, Junghui Chen, and Lei Xie. "Batch Process Modeling with Few-Shot Learning." Processes 11, no. 5 (2023): 1481. http://dx.doi.org/10.3390/pr11051481.

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Batch processes in the biopharmaceutical and chemical manufacturing industries often develop new products to meet changing market demands. When the dynamic models of these new products are trained, dynamic modeling with limited data for each product can lead to inaccurate results. One solution is to extract useful knowledge from past historical production data that can be applied to the product of a new grade. In this way, the model can be built quickly without having to wait for additional modeling data. In this study, a subspace identification combined common feature learning scheme is propo

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DE, LEON IZEPPI GERARDO ANTONIO, CHRISTIAN DREXLER, and DIRK KIRSCHNECK. "Preliminary economic assessment of a polymer production plant in batch and continuous manufacturing." Chimica Oggi - Chemistry Today 36, no. 5 (2018): 35–39. https://doi.org/10.5281/zenodo.1584964.

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Comparison of a batch and continuous process from an economical point of view. For this analysis, a specific polymer plant was used as case study. Chimica Oggi - Chemistry Today 36(5) https://www.teknoscienze.com/tks_article/preliminary-economic-assessment-of-a-polymer-production-plant-in-batch-and-continuous-manufacturing/

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47

Jain, Santosh, Jin-Kuk Kim, and Robin Smith. "Process Synthesis of Batch Distillation Systems." Industrial & Engineering Chemistry Research 52, no. 24 (2013): 8272–88. http://dx.doi.org/10.1021/ie400003p.

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Kumar, Sandeep, Neetesh Kumar Jain, Apoorva Tiwari, and Supriya Shidhaye. "Process Validation of Solid Antioxidant Skin Supplement Tablets." International Journal of Medical Sciences and Pharma Research 8, no. 2 (2022): 100–107. https://doi.org/10.22270/ijmspr.v8i2.45.

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Antioxidants, protects the skin from cell damage and harmful rays. So, there is a need to kill the skin problems. The Aim of this present work is to study about oral antioxidants and its benefits for our skin and body hence this formulation can be used as health supplements. The purpose of this work is to prepare and perform process validation of antioxidant tablet formulation. The study consists of manufacturing of the three batches of 1 lakh tablets each of solid Antioxidant tablets. Each batch of Antioxidant tablets consists of Reduced L-Glutathione, Pycnogenol, Alpha Lipoic Acid, Vitamin C

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Aleksievska Beldedovska, Katerina, Jelena Acevska, Aneta Dimitrovska, and Miroslava Ilievska. "Challenges of manufacturing site in batch certification and release in European Union." Macedonian Pharmaceutical Bulletin 65, no. 2 (2019): 3–9. http://dx.doi.org/10.33320/maced.pharm.bull.2019.65.02.001.

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A comprehensively designed Pharmaceutical Quality System (PQS) incorporating Good Manufacturing Practice and Quality Risk Management implemented, maintained and continuously improved, allows a consistent delivery of products with appropriate quality attributes. The manufacturer in the third country and the batch certification and release site in EU belong to the same organization operating under a corporate Pharmaceutical Quality System. A signed Quality Agreement between both parties provides improvement of the Pharmaceutical Quality System and continual maintenance of the quality of the medi

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50

Li, Jianlin, Yuepeng Zhang, Youngho Shin, and Ozgenur Kahvecioglu. "(Invited) Materials Manufacturing and Process Scale up for Energy Storage." ECS Meeting Abstracts MA2024-01, no. 4 (2024): 639. http://dx.doi.org/10.1149/ma2024-014639mtgabs.

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The demand for energy storage devices is ever increasing with their applications to electrical vehicles and grid storage. To keep up the ever-growing battery manufacturing capacity, it is critical to develop novel processes that can produce materials and electrodes at scale at low cost and with high throughput and low environmental impact. This presentation will discuss multiple processes in material and electrode manufacturing from batch to continuous or roll-to-roll operation. Benefits and challenges of each process will be discussed.

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