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1

Bayless, Brittany N. ""The show windows of a state" a comparative study on classification of Michigan, Indiana , and Ohio parks /." Connect to this title online, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1143423813.

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2

Kähni, Amaya Glaría. "Análise do desempenho luminoso através de uma janela em sacada : estudo comparativo para os climas de Maceió, Brasil e Valparaíso, Chile." Universidade Federal de Alagoas, 2010. http://repositorio.ufal.br/handle/riufal/704.

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This present dissertation focuses on the study of the daylight performance produced by the use of Bow Window in the residential sector. The system Bow Window is a simply designed window facing outward from the façade. Moreover this architectural element is influenced by a multitude of cultural trends and imported from various parts of the world. Nowadays in Chile the use of such windows has been largely used, regardless of the climatic aspects. Similarly, in Brazil, these architectural elements been used in the same way. The investigation has considered the Bow Window as a space in between more likely as a intermedium space, therefore the focus of this research project is to contribute to the daylight performance of the above named spaces. The methodology used involves the comparative study between Bow Window and simple window in dwellings in two cities; Maceió, Brazil and Valparaíso, Chile. In addition to this, the methodology includes the analysis of vertical and horizontal solar protection.The study was carried out using software as the main tool TropLux. The base case was a room model including Bow Window in its configuration. From the results can be concluded that the Bow Window contribute to the daylight uniformity within the model, due it can decrease the high iluminance in the closest areas near to the studied window when compared with a standard window. Furthermore, the horizontal and vertical sun protections applied to Bow Window have shown to be useful to decrease the high daylight levels, particularly in the areas with higher solar radiation according to the Bow Window orientation and hourly transition.
Fundação de Amparo a Pesquisa do Estado de Alagoas
A presente pesquisa estuda a influência luminosa produzida no uso da Janela em Sacada em habitações. A "Janela em Sacada" é um tipo de janela saliente da fachada, de desenho sensível à influência dos movimentos culturais. Este espaço de vidro foi importado pelos diversos lugares no mundo. Na atualidade, no caso de Chile, seu uso tem sido intenso e indiscriminado, produzindo um elemento arquitetônico que desconsidera os aspectos climáticos. No entanto, no caso de Brasil, também vêm sendo utilizadas algumas configurações similares destes espaços de transição. O objetivo principal deste trabalho é contribuir para o estudo dos espaços de transição, por meio da análise do desempenho luminoso da Janela em Sacada . A metodologia utilizada consiste em um estudo comparativo do desempenho luminoso entre uma Janela em Sacada e janelas simples, para as cidades de Maceió, Brasil e Valparaíso, Chile; incluindo a utilização de protetores solares verticais e horizontais. As simulações realizam-se por meio de simulação computacional através do software TropLux, utilizando-se um modelo padrão de sala que inclui a Janela em Sacada em sua configuração. Dos resultados e análise, pode-se concluir que a Janela em Sacada contribui com um maior ganho da iluminação nos ambientes, esta janela diminui o desempenho luminoso comparado com uma janela simples, até um 18%, principalmente na área perto da abertura, o que poderia contribuir com uma maior uniformidade luminosa na sala. Em relação a uma janela simples com beiral, a Janela em Sacada aumentará os níveis de iluminâncias, em até um 13%; contribuição gerada pela influência do plano inferior desta janela, que atua como elemento refletor. E, o uso de protetores solares na configuração desta janela, ajuda a diminuir, em até 50%, os altos níveis de iluminação das áreas com maior radiação, segundo a orientação e hora do dia.
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3

Mackey, Bill. "BINOCULARS AT THE BAY WINDOW: COHOUSING IN AMERICA." The University of Arizona, 1994. http://hdl.handle.net/10150/555248.

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4

Sandgren, Marie, and Linnéa Yngvesson. "Utveckling av ett flerbostadshus i massivträ." Thesis, KTH, Byggvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-174282.

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Stockholm är ett av de län som växer snabbast, därför behöver länet byggas ut. Idag är klimat och miljöfrågor viktiga och påverkar bland annat bostadbyggandet. Massivträ är ett stommaterial som är på framfart tack vare dess miljö- och klimatfördelar. Berg | C.F. Møller ska på uppdrag av HSB Stockholm projektera ett bostadsområde i södra Stockholm, Årsta. Området som ska projekteras består av ett antal olika hustyper. För examensarbetet har ett flerbostadhus i åtta våningar valts. Huset ska projekteras med en massivträstomme, därför har en fördjupning inom massivträteknik varit nödvändig för att ta fram förslagshandlingar innehållande ritningar och konstruktionsdetaljer. Analyser av området har gett inspiration till utformning av det slutliga resultatet. Stor vikt har lagts på att rita yteffektiva lägenheter med hänsyn till Svensk Standard, Byggnadsutformning – Bostäder – Invändiga mått, och till kriterier som valts för projektet. Resultatet består av förslagshandlingar för flerbostadshuset, som gavs ett unikt utseende med burspråk i spegelglas, för att skapa en variation i fasaden, och med en heltäckande träfasad för att indikera på det valda stommaterialet. Flerbostadhuset är projekterat för 15 treor och 14 tvåor med en kommersiell lokal i markplan för att skapa rörelse i kvarteret.
Stockholm is one of the regions with the fastest growth, therefore the region requires to be expended. Climate and environmental issues are important today and influences the construction of buildings among other things. Solid wood is a structure material which is on the rampage thanks to its climate- and environmental advantages. Berg | C.F. Møller will on behalf of HSB Stockholm project a dwelling area in Årsta, southern Stockholm. The projected area consists of a number of different house types. For this thesis an apartment building in eight flats has been chosen. The house will be projected with solid wood, therefore a deep study has been made in the subject of construction made of solid wood. This in order to produce drawings and construction details. Analyses of the area have inspired the design of the final result. A great importance in the project has been drawing space-efficient apartments with respect to the Swedish Standard, Building Design – Housing – Interior dimensions, and to criteria which has been chosen for the project. The result is made up of concept drawings for the apartment building, which was given a unique look with a bay window in mirror glass. To create a variation in the facade. The apartment building is built with a wood facade to indicate the selected structure material and is projected for 15 threes and 14 twos with a commercial local at ground floor to create movements in the surroundings.
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5

Haag, Christian. "Temporal and spatial wind field distribution in Delaware Bay." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 9.11 Mb., 62 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:1430767.

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Thesis (M.E.E.)--University of Delaware, 2006.
Principal faculty advisors: Kenneth E. Barner, Dept. of Electrical and Computer Engineering; and Mohsen Badiey, Dept. of Marine and Earth Studies. Includes bibliographical references.
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6

Delgado, Raymond R. "Mapping coastal surface winds in Monterey Bay using high frequency radar." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1999. http://handle.dtic.mil/100.2/ADA362924.

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Thesis (M.S. in Meteorology and M.S. in Physical Oceanography) Naval Postgraduate School, March 1999.
"March 1999". Thesis advisor(s): Jeffrey D. Paduan, Carlyle H. Wash. Includes bibliographical references (p. 121-122). Also available online.
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Foster, Michael D. "Evolution of diurnal surface winds and surface currents for Monterey Bay." Thesis, Monterey, California. Naval Postgraduate School, 1993. http://hdl.handle.net/10945/39684.

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Approved for public release; distribution is unlimited.
The diurnal-period fluctuations of winds and surface currents are analyzed for September 1992 in and around Monterey Bay. Wind records are compared for three coastal stations and two mooring sites. Remotely-sensed surface current observations from two CODAR (HF radar) sites are used to explore the ocean's response to diurnal-period forcing. An average diurnal cycle is formed at each wind station and at all CODAR bins. The earliest sea breeze response is seen at the coastal wind stations where morning winds accelerate toward the coastal mountain ranges. A few hours later, the coastal winds accelerate to the southeast down the Salinas Valley. Offshore afternoon winds rotate from their normal alongshore orientation to also become aligned with the valley. The CODAR-derived surface currents respond in less than the two-hour sampling rate to the onset of the diurnal onshore winds. Currents accelerate in the direction of the Salinas Valley. As the day progresses, the more offshore currents rotate clockwise out from under the winds in a possible Ekman or inertial adjustment that continues throughout the night and spreads onshore. In the afternoon, a complicated eddy pattern develops near shore in a possible response to the coastal boundary.
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Spiro, Jaeger Gualtiero Victor Rudi. "Stratified and stirred : monsoon freshwater in the Bay of Bengal." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122332.

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Thesis: Ph. D., Joint Program in Oceanography/Applied Ocean Science and Engineering (Massachusetts Institute of Technology, Department of Earth, Atmospheric, and Planetary Sciences; and the Woods Hole Oceanographic Institution), 2019
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 113-121).
Submesoscale ocean dynamics and instabilities, with characteristic scales 0.1-10 kin, can play a critical role in setting the ocean's surface boundary layer thickness and associated density stratification. Submesoscale instabilities contribute to lateral stirring and tracer dispersal. These dynamics are investigated in the Bay of Bengal, motivated by the upper ocean's potentially coupled interactions with Monsoon winds and convection. The region's excess precipitation and runoff generates strong salinity gradients that typically set density fronts and stratification in the upper 50 m. Since we cannot synoptically measure currents containing fast-evolving and oscillating components across the submesoscale range, we instead analyze passive tracer distributions (spice = density-compensated temperature (T) and salinity (S) anomalies), identifying signatures of flows and testing dynamical theories.
The analysis is based on over 9000 vertical profiles of T and S measured along ~4800 km of ship tracks in the Bay of Bengal during ASIRI and MISO-BOB expeditions in 2013, 2015, and 2018. Observations in the surface mixed layer reveal ~1 km scale-selective correlation of surface T and S, with compensation reducing cross-front density gradients by ~50%. Using a process study ocean model, we show this is caused by submesoscale instabilities slumping fronts, plus surface cooling over the resultant enhanced salinity stratification, potentially thwarting the forward cascade of energy. In the stratified interior, we present a spectral analysis of horizontal spice variance statistics from wavenumber k ~0.01 cpkm to ~1 cpkm. At scales <10 km, stratified layers that are closer to the surface exhibit redder passive tracer spectra (power spectra k⁻³, gradient spectra k⁻¹) than predicted by quasi-geostrophic or frontogenetic theories.
Complimentary observations reveal spice patterns with multiple, parallel, ~10 m thin layers, crossing isopycnals with O(10⁻⁴) slopes, coherent over at least 30-80 kin, with coincident layers of stratification anomalies. Comparison with shear measurements, and a numerical process study, suggest that both submesoscale sheared eddies, and thin near-inertial waves, form such layers. Fast formation timescales and large aspect ratios suggest they enhance horizontal mixing by shear dispersion, reducing variance at ~1-10 km scales.
by Gualtiero Victor Rudi Spiro Jaeger.
Ph. D.
Ph.D. Joint Program in Oceanography/Applied Ocean Science and Engineering (Massachusetts Institute of Technology, Department of Earth, Atmospheric, and Planetary Sciences; and the Woods Hole Oceanographic Institution)
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Etxeberria, Aitor. "CFD simulation and analysis of glazing bar effects on heat and airflow inside a two-pane window." Thesis, Högskolan i Gävle, Avdelningen för byggnadsteknik, energisystem och miljövetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-30129.

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10

Eisazadeh, Moghaddam Arash. "Pocket beach wave processes and current systems investigated via field and numerical modelling studies: A case study of Okains Bay." Thesis, University of Canterbury. Geography, 2015. http://hdl.handle.net/10092/10478.

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Confined coasts in general, and pocket beach environments in particular, are under huge development pressures worldwide, not least due to their sheltered nature and perceived shoreline stability. However, understanding of their physical functioning is poor in comparison to that of open coast beaches. This study aims to improve understanding in terms of the existing gaps in knowledge of wave processes and nearshore currents, and also to examine the importance of local wind and tide factors in generating nearshore currents, in micro-tidal pocket beaches. The boundaries of embayments are generally recognized as important controls of their beach processes and responses, yet little detailed knowledge exists of how the exact embayment dimensions and characteristics influences these processes. One key embayment feature the influence of which is poorly understood is the downcoast headland. In this thesis, field observations plus Zanuttigh and Van der Meer’s (2008) approach, and the SWAN wave model were used to evaluate the downcoast headland effects on wave processes within Okains Bay, an example pocket beach environment. The results showed that incident wave heights and directions were significantly influenced by wave reflection processes from the downcoast headland inside the bay. The intensity of reflection effects on wave characteristics inside the pocket beach varied according to approaching wave direction. Reflection effects reduced when waves approached from angles close to parallel to the headlands, increasing towards headland-perpendicular wave approaches. Field observations and the XBeach model were used to examine whether or not tides can significantly influence nearshore currents within example and model pocket beach environments. Results indicated that tides can be the primary driver of nearshore currents close to the bed inside micro-tidal pocket beaches, depending on incident wave conditions. In areas of micro-tidal pocket beaches exposed to direct approaching waves, currents were wave driven, while in areas further into the bay that experienced headland filtering of their wave environment, currents were mainly tide generated. The results of this study demonstrated how the current circulation system within micro-tidal pocket beaches is related to the incoming directions of offshore waves. If high energy waves approach oblique or normal to the shoreline (with the assumption that the shoreline is at 90° to the headlands), the current system was found to consist of longshore currents influenced by headlands, plus a rip current in the center of the shoreline or a toporip in proximity to headlands. The location of the rip current or toporip was determined by the direction of approaching incident waves. This study also examined the behavior of local winds in a pocket beach environment and their consequent effects on nearshore currents. Results for Okains Bay show that local winds tended to blow in offshore and onshore directions, as the bay is located in a valley, so orographic effects channel and shift the wind directions to angles close to offshore and onshore directions inside the bay. Results also indicated that local winds influence the hydrodynamic currents of pocket beaches that are confined by elevated topography, producing semi-cross shore influences since the winds are topographically channelled to blow in predominantly offshore and onshore directions. This research significantly refines our understanding of micro-tidal pocket beach wave and current processes, including quantification of the filtering effects of headlands on their wave environments, revealing the various and variable influences of tides and winds compared to in open coast beaches; and, significantly, highlighting the role of downcoast headland wave reflection effects. With regard to the latter, this research elucidates some key process differences between pocket and embayed beaches and clarifies reasons why the application of embayed beach models that include refraction and diffraction but exclude reflection effects to the study of pocket beaches is inappropriate for studying pocket beaches. This research also provides methodological and topic suggestions for future research on pocket beach environments, including how to use the improved hydrodynamic knowledge of this study in future studies seeking to better understand pocket beach sediment systems, a topic that was beyond the scope of the current research.
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Agarwal, Dinesh. "Scientific High Performance Computing (HPC) Applications On The Azure Cloud Platform." Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/cs_diss/75.

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Cloud computing is emerging as a promising platform for compute and data intensive scientific applications. Thanks to the on-demand elastic provisioning capabilities, cloud computing has instigated curiosity among researchers from a wide range of disciplines. However, even though many vendors have rolled out their commercial cloud infrastructures, the service offerings are usually only best-effort based without any performance guarantees. Utilization of these resources will be questionable if it can not meet the performance expectations of deployed applications. Additionally, the lack of the familiar development tools hamper the productivity of eScience developers to write robust scientific high performance computing (HPC) applications. There are no standard frameworks that are currently supported by any large set of vendors offering cloud computing services. Consequently, the application portability among different cloud platforms for scientific applications is hard. Among all clouds, the emerging Azure cloud from Microsoft in particular remains a challenge for HPC program development both due to lack of its support for traditional parallel programming support such as Message Passing Interface (MPI) and map-reduce and due to its evolving application programming interfaces (APIs). We have designed newer frameworks and runtime environments to help HPC application developers by providing them with easy to use tools similar to those known from traditional parallel and distributed computing environment set- ting, such as MPI, for scientific application development on the Azure cloud platform. It is challenging to create an efficient framework for any cloud platform, including the Windows Azure platform, as they are mostly offered to users as a black-box with a set of application programming interfaces (APIs) to access various service components. The primary contributions of this Ph.D. thesis are (i) creating a generic framework for bag-of-tasks HPC applications to serve as the basic building block for application development on the Azure cloud platform, (ii) creating a set of APIs for HPC application development over the Azure cloud platform, which is similar to message passing interface (MPI) from traditional parallel and distributed setting, and (iii) implementing Crayons using the proposed APIs as the first end-to-end parallel scientific application to parallelize the fundamental GIS operations.
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ADISSI, FLÁVIA. "THE CONTRIBUTION OF OCEAN DRIFTERS AND NUMERICAL SIMULATIONS OF OCEAN CURRENTS AND WINDS IN SUPPORT OF THE TERRITORIAL PLANNING: THE CASE OF GUANABARA BAY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2016. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=27618@1.

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Este trabalho aborda a questão da movimentação e acúmulo do lixo flutuante na Baía de Guanabara e contextualiza a problemática da poluição da Baía e seu entorno a partir de diversos temas inter-relacionados, como: o uso dos derivadores e a sua analogia com o lixo flutuante; a existência de projetos que têm ajudado no rastreamento do lixo flutuante na Baía a partir do mapeamento de correntes superficiais e ventos; o saneamento da bacia hidrográfica da Baía, a qualidade da água de seus afluentes e a análise da população que reside no seu entorno; o entendimento de uma visão mais humanista e ecológica no redesenho das cidades e também programas internacionais de revitalização de corpos d água degradados. Dentro deste contexto, são feitas reflexões e análises integradas a partir de uma modelagem da probabilidade de transporte de resíduos da Baía e da paisagem encontrada em seu entorno, através da utilização de produtos cartográficos. Tais análises consideram os dados levantados nos quatro mapas que são apresentados, de forma a prover uma visão mais ampla e integrada do espelho d água e também do entorno da Baía. O objetivo deste trabalho foi entender como o espaço territorial e a ocupação urbana do entorno da Baía podem impactar a poluição do espelho d água da Baía e por ela serem impactados de forma a contribuir com programas de despoluição. Foi feito então um recorte em quatro regiões e realizada uma análise integrada para cada, de forma a prover um melhor entendimento a partir da exemplificação. A análise integrada proporciona uma visão mais abrangente da questão da poluição, auxiliando os gestores dos programas de despoluição a encontrarem relevantes informações para priorizar as ações a serem tomadas.
This work approaches the issue of the movement and accumulation of floating litter in the Guanabara Bay, in Rio de Janeiro, Brazil. It contextualizes the problem of the pollution in the Bay and surroundings, and it does so from several different interrelated issues, such as the use of ocean drifters and their analogy with the floating litter; the existence of projects that have been helping in the tracking of the floating litter in the Bay from the mapping of the surface currents and the winds; the sanitation efforts in the hydrographic basin of the Bay; the quality of the water in the rivers that debouch into the Bay and a better understanding of the population that live in the area; the necessity of a more humanistic and ecological view in the planning of those cities; and also international programs to revitalize degraded water bodies. One of the objectives of this dissertation is to understand how the territorial space and the urban occupation of the Bay s surroundings can impact the pollution in the Bay and be impacted by that pollution. So the entire region was divided in four areas and an integrated analysis was made for each area so that a better understanding could be provided by exemplification. Such integrated analysis provides a more comprehensive view of the pollution problem and helps the depollution program officers to find relevant information and better prioritize actions. The Guanabara Bay plays a strategic role not only around the towns and cities that are part of its hydrographic basins, but in the whole state of Rio de Janeiro and also the entire country. It is one of the most important marine ecosystems from the social, economic and environmental points of view. It is located in the Rio de Janeiro city metropolitan area, with the Brazilian coast s largest population concentration (about 10 million people, or 80 percent of the state s population). A national security area, the Bay shelters two naval bases, one navy shipyard, the Rio de Janeiro Port (the second largest in the country, with more than 2 thousand ship moorings annually), two airports (Antonio Carlos Jobim, and Santos Dumont), and other shipyards and marinas. The Guanabara Bay is also way for innumerous cargo and passenger ferryboats, fishing boats, and other boats for leisure and tourism. The water in the Bay is also used for water sports and aquaculture (fish farming). (KJERFVE, 1997; BERGAMO, 2006 apud CARVALHO, 2011).
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Cherrett, Robin Corey. "Observed and simulated temporal and spatial variations of gap outflow region." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2006. http://library.nps.navy.mil/uhtbin/hyperion/06Sep%5FCherrett.pdf.

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Thesis (M.S. in Meteorology and Physical Oceanography)--Naval Postgraduate School, September 2006.
Thesis Advisor(s): Qing Wang, Wendell A. Nuss. "September 2006." Includes bibliographical references (p. 61-62). Also available in print.
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Hemberger, Glen J. "Selected Songs for Chamber Winds and Soprano: Rediscovering a Forgotten Repertoire of John Philip Sousa." Thesis, connect to online resource. Access restricted to the University of North Texas campus, 2001. http://www.library.unt.edu/theses/open/20013/hemberger%5Fglen/index.htm.

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Thesis (D.M.A.)--University of North Texas, 2001.
Includes 8 concert and recital programs (1997-2001). Accompanied by recital, recorded Sept. 6, 2001. Includes bibliographical references (p. 100-107).
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Řehánek, Martin. "Detekce objektů pomocí Kinectu." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2012. http://www.nusl.cz/ntk/nusl-236602.

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With the release of the Kinect device new possibilities appeared, allowing a simple use of image depth in image processing. The aim of this thesis is to propose a method for object detection and recognition in a depth map. Well known method Bag of Words and a descriptor based on Spin Image method are used for the object recognition. The Spin Image method is one of several existing approaches to depth map which are described in this thesis. Detection of object in picture is ensured by the sliding window technique. That is improved and speeded up by utilization of the depth information.
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"Forming a Bay Window Issue, Case and Design." 2014. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292569.

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Chen, Che-Cheng, and 陳正哲. "Applying TRIZ method on improvement of iron bar windows." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/18975701955389853350.

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碩士
國立勤益科技大學
工業工程與管理系
102
Within the building infrastructure of Taiwan, the culture of buildings implementing iron bars on windows to prevent theft and for safety reason such as children accidentally falling is still extremely popular. But ordinary people seldom opens the iron bar windows, combining the humidity in Taiwan with years of rain and sunshine will eventually lead to the rusting of the locks. Even if the locks are in peak condition, when fire erupts, the decrease in visibility caused by the smoke and fumes will make finding the key more difficult. Even if the location of the key is known, moving around in the smoke will shorten the time needed for escape. The main objective of the research is to improve the day-to-day regular lock based design of the metal bared window, using patented information search and analysis to review the related patents, and the TRIZ innovation theory to create a brand new product design key-points. And by taking into account the regular design, to implement the user friendly control conception, after the main design module is complete, confirm that the design conception does not have any conflict with the patented information and produce an research conclusion. The research findings are the following points. 1.Design an elongated bar with which serves as an locking mechanism with a push button release, to replace the normal bar and key-lock combination on the windows, in case of emergency, press the release button and sway the elongated bar to open the lock, to achieve a fast and easy escape method bypassing the need of keys. 2.The design is applicable for most barred window modules on apartments or balconies, this design will only acquire a modification to the original emergency escape hatch. By changing the direction of the hatch and adding two elongated locking bar with a press-release button, the new emergency mechanism’s installation will not require changing the style of the original barred window.
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"Circulation of Tampa Bay in relation to tides, winds and buoyancy driven convection [electronic resource] / by Zhen Li." 1993. http://purl.fcla.edu/fcla/tc/fhp/SF00000276.pdf.

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Ptak, Malgorzata. "A window into autism's early development: features of behavioral data in a longitudinal multisystem evaluation in infants at high risk for autism." Thesis, 2015. https://hdl.handle.net/2144/16254.

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Autism spectrum disorders (ASDs) are a biologically-based and behaviorally-defined spectrum of conditions which impact development. These conditions affect and are diagnosed based on features in three psychological and behavioral domains: social interaction, communication, and repetitive behaviors. Developing better ways to identify early signs of autism, whether through behavioral or other types of measures, is important because it will allow children to gain access to interventions and treatments earlier, which has demonstrated positive outcomes. Over the past 10 years, the prevalence of reported autism cases has increased. As a result, much research has focused on the etiology and phenotype of autism. Investigations seeking early signs of autism have generally studied vulnerable populations, particularly infants with an older sibling diagnosed with autism. Aside from observable behavioral differences, biological abnormalities, often within the gastrointestinal and immune systems as well as endocrine, autonomic and other systems, have been observed in a significant number of children diagnosed with autism. These features raise the possibility that cellular and tissue change in body and brain may be altering brain function such that behaviors emerge later and downstream of these cellular and tissue problems. However, research on the pathophysiology underlying these medical features, and particularly regarding how they develop in infancy, has received almost no attention. Such investigation would require measuring pathophysiological and medical features alongside current standard measures of behavioral and phenotypical presentations of autism. This thesis describes a study, funded by the Department of Defense Autism Research Program and carried out at the Massachusetts General Hospital Lurie Center, that proposed to look for early markers of autism in the pathophysiological domains in high risk infants and place them into developmental context by correlating these observations (some of which might potentially become early markers) with well-established neurocognitive measures. The goal of the study is to find biomarkers of clinical importance that reflect the pathophysiologial development of autism which might substantially precede behavioral changes that are currently used as a standard of diagnosis, but are not developmentally apparent or reliably measurable until well into the second or third year of life. While the overall scope of the study encompassed a range of systemic and nervous system measures as well as neurocognitive assessments, the focus of this thesis is mainly on a subset of the behavioral and neurocognitive measures collected through the study, specifically the Autism Diagnostic Observation Scale (ADOS), Autism Observational Scale for Infants (AOSI), Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS). Subject development was tracked and assessed through developmental quotients (DQs) and then correlated to measures designed to identify autistic-like features. Results demonstrate that verbal development was the most significant indicator for autism. Additionally, delay in communication preceded problems with socialization. The analysis and information used for this thesis will contribute to the infrastructure utilized by the investigators for assessing further behavioral data. In addition, this behavioral data and the metrics generated in these analyses will be analyzed in relation to physiological data (e.g. brain, autonomic, metabolic, immune, and microbiome data). Tracking early biomedical development, especially alongside the current standard of observing behavioral development, has the potential of offering more comprehensive understanding of the brain-behavior-body relationship in children diagnosed with ASD, which can hopefully contribute to a non-invasive, more accurate, and earlier method of diagnosis and to the development of more treatment options.
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