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1
Švadlenková, Veronika. "Analýza sortimentu EVONA a.s." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-113016.
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This master's thesis is focused on analysis of EVONA a.s. product range, which is manufacturing company. Aim of this study is to analyze the range of underwear, thermal underwear and hosiery and then to propose optimization measures. The theoretical part is devoted to methods which focus on analyzing the marketing environment and product mix. In the practical part, internal company data of EVONA a.s. served to analyze the product range by using Boston Consulting Group matrix and General Electric Business matrix. To illustrate the situation a survey was carried out and it helped in the final recommendations of the product range.
2
Vařechová, Michaela. "Strategická analýza společnosti COLOR EXPERT ŠTORCH, CZ s.r.o." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-113208.
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Abstract: The aim of the Master's thesis was to perform strategic analysis of COLOR EXPERT ŠTORCH, CZ s.r.o. company. Theoretical-methodological instruments are presented in the first part of the thesis. The analysis of the microenvironment, macroenvironment, the analysis of the internal sources and the methods integrating the external and internal analysis are applied successively. The company is completely introduced in the practical part of the thesis. Then the particular methods are applied. The conclusion contains the results evaluation and the recommendations for the future of the company.
3
Černý, Michal. "Výzkum využití manažerských nástrojů v praxi." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2013. http://www.nusl.cz/ntk/nusl-374715.
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This Master’s thesis evaluates the survey that mapped using management tools in contemporary practice. Respondents were senior and middle management of companies from the Czech Republic. They had to answer what they expect from the tools and what they think about the various claims concerning the parameters of the attractiveness of the market and competition. The survey was focused on portfolio analysis.
4
Velecká, Aneta. "Analýza produktového portfolia farmaceutické firmy MEDA Pharma, s.r.o." Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-264258.
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The aim of this study is to analyse the portfolio of the pharmaceutical company Meda Pharma s.r.o. and then, according to the results, suggest a marketing stratégy to be effective up to 2020. The work has two parts, theoretical and practical. The theoretical part explains the basic concepts related to the market, marketing, marketing mix, marketing strategy and its instruments. This part is also dedicated to concepts relating to the pharmaceutical industry. The practical part is focused on analysis of portfolio of the company. I will use the marketing mix, the Boston matrix, evaluate the largest competitors in each product and focus also on the profitability of products of the company. In conclusion, I will propose a marketing strategy to be put in place by 2020.
5
Kozelek, Pavel. "Marketingová strategie firmy." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2010. http://www.nusl.cz/ntk/nusl-222496.
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The diploma thesis "Marketing strategy of a company“which is divided into theoretical, analytical and design. The main objective of this thesis is to design a marketing strategy of the manufacturing company, focusing on key products and strengthen its position in the chosen market segment. The chosen strategy is built on identifying key product (the product or at least profitable product, which is losing market position), its detailed analysis and recommendations for appropriate development activities, including its location on the selected market. These outputs are also the basis for the formulation and determination of optimal strategic objectives and action steps to comply with this proposed strategy.
6
Shejbalová, Adéla. "Analýza výrobkového portfolia společnosti Whirlpool." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-71824.
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This master's thesis is focused on analysis of Whirlpool CR, spol. s r. o. product range. Main objective of this thesis is to analyse Whirlpool CR freestanding home appliances product range and suggest reccomendations for its optimalization. The theoretical part is devoted to methods for the analysis of macro-and microenvironment, which are then applied in practical part of work. Based on internal company data Whirlpool CR, spol. s r. o. is provided the analysis of the marketing mix. The analysis of range and recommendations for its optimization are performed with the Boston Consulting Group matrix.
7
Válek, Petr. "Analýza vybrané firmy." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2010. http://www.nusl.cz/ntk/nusl-222433.
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The diploma thesis aims at analyzing Miss Claire Ltd., a distributor of perfumes and cosmetic goods. The situation of external and internal environment is described based on Porter Value Chain, indicators of financial analysis, PESTE and SWOT matrix. GE model and BCG matrix serve as complementary tools. All suggested strategies fulfill SMART criteria as well as strategic goal of Miss Claire Ltd, which is achievement of profitability and stabilization of market position.
8
Smolík, Kamil. "Marketingová strategie společnosti Motiv Press, s.r.o." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2010. http://www.nusl.cz/ntk/nusl-222795.
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The aim of master´s thesis is the suggestion of marketing strategy for Motiv Press company. The first part of the thesis is a detailed descreption of theoretical resources which I gained during my studying Faculty of Business and Management. The second part of the master´s thesis is focused on the complex analysis of the current situation of the company. On the basis of these facts I Works out a marketing strategy which contains a couple of proposals and designs including their time frame and economic characteristics.
9
Velček, Martin. "Návrh marketingové strategie." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2010. http://www.nusl.cz/ntk/nusl-264871.
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The subject of this thesis is to analyze the current situation and design a marketing strategy. The work is divided into three parts: theoretical, analytical and design. The first part is a theoretical overview of the problem of marketing strategy, a description of analytical marketing tools and features in the building. The second part focuses on the analysis of the situation in the company using financial analysis, PEST analysis, Porter's five forces analysis, BCG matrix and SWOT analysis. The third part is to design, formulate marketing strategy using the marketing mix 6P. The conclusion is devoted to communication and promotion mix.
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Němec, Pavel. "Ekonomická analýza společnosti STUDENT AGENCY, k.s." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-198404.
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The Master's Thesis analyzes in detail the company STUDENT AGENCY, k.s.. This thesis includes a financial analysis of the years 2008 - 2012, followed by a strategical analysis of STUDENT AGENCY'S current operations. All the gained information is synthesized with the SWOT analysis that creates the base for the author's recommendations regarding the business strategy. The Master's Thesis consists of the introduction, the theoretical section, the practical section and the conclusion. In the introduction the basic facts are explained and the motives for writing this thesis are described. The used methodology is described in the theoretical section and then applied on the company in the practical section. In the closure the summary of the findings is made.
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Tomášková, Alena. "Strategic Analysis of an Enterprise." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-72271.
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Main theme of this work was to do the strategic analysis of the enterprise Hotel Plzeň with application of analysis and methods, that should show, which strong and weak points has this company and identify her opportunities and threats. To specify it, was the base for the formulation of a strategy, proposals and recommendations for next development. After executed analysis came out, that the enterprise has a lot of strengths, on which it can lean in future and strong it -- for example its staff, costumers and services ; and has many opportunities for using too. The end of work was dedicated to proposals for next development of business activities and how to improve the financial situation of this company.
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Лєженцев, І. В. "Удосконалення міжнародної посередницької діяльності дилера у сфері постачання зброї (на прикладі ТОВ «Фенікс ЛЛС»)." Thesis, Одеський національний економічний університет, 2021. http://local.lib/diploma/Liezhentsev.pdf.
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Доступ до роботи тільки на території бібліотеки ОНЕУ, для переходу натисніть на посилання нижчеУ роботі розглядаються теоретичні аспекти торговельно-посередницької діяльності, визначається вплив внутрішнього та зовнішнього середовища на міжнародну торговельну діяльність підприємства та методи її оцінки. Проаналізовано зовнішньоекономічну діяльність ТОВ «Фенікс ЛЛС», виявлено внутрішні та зовнішні чинники, які перешкоджають успішнішому функціонуванню підприємства. Запропоновано напрями вдосконалення міжнародної торговельно-посередницької діяльності підприємства, розроблено заходи щодо оптимізації асортименту товарної продукції.
The bachelor's thesis consists of three sections. The object of the study is the international trade and intermediary activities of «Phoenix LLS» LLC and the process of its improvement. The theoretical aspects of trade and intermediary activity are considered in the work, the influence of internal and external environment on the international trade activity of the enterprise and methods of its estimation are defined. The foreign economic activity of «Phoenix LLS» LLC is analyzed, the internal and external factors that hinder the successful functioning of the enterprise are revealed. The directions of improvement of the international trade and intermediary activity of the enterprise are offered, measures on optimization of assortment of marketable production are developed.
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Pikula, Michal. "Marketingová strategie společnosti ZDT spol. s r.o." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2016. http://www.nusl.cz/ntk/nusl-254437.
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This Diploma Thesis deals with problems of marketing strategy proposal for the company ZDT spol. s.r.o. – Agriculture and transport machinery Ltd. A marketing strategy proposal based on theoretical knowledge, analysis of the company’s current condition and questionnaire survey is introduced. This proposal should lead to strengthening our position on domestic market, gaining new market outlet and as a result of this to higher sales and profits.
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Morávková, Jana. "Návrh marketingové strategie pro salón D.B.Art - Dagmar Bencová." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2015. http://www.nusl.cz/ntk/nusl-224930.
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This thesis focuses on a marketing strategy proposal of a cosmetic salon D. B. Art – Dagmar Bencova. There is an external and internal enviroment analysis included. Data of this analysis was used for a design of a marketing strategy. This strategy includes a recommendations, which mainly lead to the increase of a market share.
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Plzák, Karel. "Podnikatelský plán." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-71997.
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This thesis formulates a business plan of established joint stock company that is dedicated to two very different business activities. The thesis consists of 5 parts - an introduction, theoretical and methodological part, the description of the analyzed company, application of selected methods, and the conclusion. The product portfolio is analyzed with a business plan of the company. By application of the business plan is implemented innovation and modernization of two principal activities. The results of application of the business plan are assessed in terms of financial analysis. Application of the business plan will help in solving main problems of the analyzed company - low profitability and high costs.
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Бережна, А. В. "Удосконалення міжнародної маркетингової діяльності торговельного підприємства (на прикладі ТОВ «Ергономіка Україна»)." Thesis, Одеський національний економічний університет, 2020. http://dspace.oneu.edu.ua/jspui/handle/123456789/12676.
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У роботі розглядаються теоретико-методичні основи дослідження міжнародної
маркетингової діяльності торговельного підприємства. Досліджено чинники впливу та методи
оцінки ефективності міжнародної маркетингової діяльності торговельного підприємства.
Охарактеризовано сучасний стан міжнародної маркетингової діяльності ТОВ
«Ергономіка Україна». Проведено SWOT- та PEST-аналіз ТОВ «Ергономіка Україна».
Проаналізовано показники ефективності міжнародної маркетингової діяльності ТОВ
«Ергономіка Україна».
Запропоновано шляхи удосконалення міжнародної маркетингової діяльності ТОВ
«Ергономіка Україна» шляхом використання бенчмаркетингу, CRM-системи, а також
розглянуто вдосконалення організаційної структури підприємства.The paper considers the theoretical and methodological foundations of the study of international marketing activities of a trading enterprise. Factors of influence and methods of estimation of efficiency of the international marketing activity of the trading enterprise are investigated. The current state of international marketing activities of Ergonomics Ukraine LLC is described. SWOT and PEST analysis of Ergonomics Ukraine LLC was conducted. The indicators of efficiency of the international marketing activity of LLC "Ergonomics Ukraine" are analyzed. Ways to improve the international marketing activities of LLC "Ergonomics Ukraine" through the use of benchmarking, CRM-system, as well as improving the organizational structure of the enterprise.
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Pereira, Melissa Pontes. "Perfil imunoproteômico da resposta humoral na revacinação com Mycobacterium bovis BCG Moreau, a cepa vacinal brasileira contra tuberculose." reponame:Repositório Institucional da FIOCRUZ, 2009. https://www.arca.fiocruz.br/handle/icict/13815.
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Previous issue date: 2009Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
A tuberculose (TB) ocupa o segundo lugar em causa de morte por doença infecciosa de notificação compulsória. Uma das estratégias para seu controle é a vacinação, e a única vacina disponível é o BCG (Bacilo de Calmette-Guèrin). Embora utilizada mundialmente, a vacina BCG apresenta diversas limitações. O Brasil utiliza a cepa Moreau para produção da vacina, sendo o único país do mundo autilizar, desde os anos 1930, esta cepa para vacinação. Como observado para outros patógenos intracelulares, a imunidade celular desempenha papel importante na proteção do hospedeiro contra a TB. O IFNy, secretado por células T, é descrito como uma citocina particularmente importante participando na resposta imune protetora, e é empregado como correlato de proteção, embora sua utilidade seja ainda questionável, sobretudo em populações adultas. Isto evidencia a necessidade de buscar biomarcadores adicionais que permitam uma correlação de proteção mais confiável. As proteínas extracelulares micobacterianas estão entre as primeiras moléculas a interagirem com o sistema imune do hospedeiro, e uma melhor compreensão de seu papel imunomodulatório poderá contribuir para o desenvolvimento de novos alvos para o controle e erradicação da TB. Uma estratégia para a identificação de proteínas imunologicamente relevantes é a análise do imunoproteoma, que combina a abordagem proteômica com uma apresentação imunológica dos dados. A caracterização de soros, provenientes de indivíduos vacinados, muitas vezes revela diferentes padrões de reconhecimento que podem ser indicativos dos diferentes graus de proteção conferidos pela vacina em uma população heterogênea Empregamos assim esta tecnologia, combinando a separação por eletroforese bi-dimensional (2DE) de antígenos protéicos extracelulares da cepa vacinal brasileira seguida de western-blot, para avaliar o perfil imunoproteômico da resposta humoral de indivíduos saudáveis, PPD negativos, revacinados com BVG Moreau e classificados como alto e baixo produtores de IFNy. Nossos resultados revelam um padrão de reconhecimento claramente distinto entre os grupos avaliados, correlacionado com o perfil de produção de IFNy. Dentre as proteínas imunoreativas identificadas, um grupo (antígenos do complexo 85) foi reconhecido por todos os soros incluídos no estudo, inclusive controles. Alguns antígenos foram reconhecidos exclusivamente pelos indivíduos classificados como alto produtores de IFNy e outros somente pelos indivíduos enquadrados no grupo de baixo produtores. Algumas proteínas foram selecionadas e produzidas sob a forma recombinante em Escherichia coli possibilitando sua avaliação mais detalhada frente aos soros individualizados. Entre os antígenos diferencialmente reconhecidos, as proteínas Mpb70 e Mpb83 se destacaram como potenciais correlatos da proteção oferecida pela vacinação com BCG Moreau, tendo sido reconhecidos somente pelos indivíduos produtores de elevados níveis de IFNy. Estudos adicionais são necessários para determinar a aplicabilidade efetiva de tais antígenos como potenciais correlatos da proteção conferida pela vacinação com BCG Moreau. Este é o primeiro relato que detalha o perfil de reconhecimento sorológico por indivíduos revacinados com BCG Moreau frente a antígenos extracelulares da cepa homóloga, e contribui para uma melhor compreensão da cepa vacinal brasileira contra a TB
Tuberculosis (TB) holds the second place as cause o f death by an infectious disease of obligatory notification. One of the stra tegies for its control is vaccination, and the only vaccine available is BCG (Bacillus Cal mette-Guerin). Although used worldwide, BCG shows various limitations. Brazil us es the Moreau strain for vaccine production, being the only country in the world to use, since the 1930s, this strain for vaccination. As observed for other intracellular pa thogens, cellular immunity plays an important role in host protection against TB. IFN γ secreted by T cells is described as a particularly important cytokine participating in protective immune responses, being used as a correlate of protection, although its uti lity remains questionable, especially in adult populations. This highlights the need to s eek additional biomarkers yielding better surrogates of protection. Mycobacterial extr acellular proteins are among the first molecules to interact with the host immune sy stem and a better understanding of their immunomodulatory role may contribute to the d evelopment of new targets for the control and eradication of TB. A strategy for t he identification of immunologically relevant proteins is the analysis of the immunoprot eome, combining a proteomic approach with an immunological presentation of the data. The characterization of sera from vaccinated individuals often reveals diff erent patterns of recognition that may be indicative of the different degrees of prote ction conferred by the vaccine in a heterogeneous population. We have thus employed thi s technology, combining the separation by two-dimensional electrophoresis (2DE) of extracellular proteins from the Brazilian vaccine strain, followed by Western b lot to assess the immunoproteomic profile of the humoral response in healthy, PPD negative subjects, re-vaccinated with BCG Moreau and classified as hig h or low producers of IFN γ . Our results reveal a clearly distinct recognition patte rn between the evaluated groups, correlating with the profile of IFN γ production. Among the immunoreactive proteins identified, one group (85 complex antigens) was rec ognized by all sera included in the study, including controls. Some antigens were r ecognized only by individuals classified as high producers of IFN γ and others only by the individuals included in the group of low producers. Some proteins were selected and produced in recombinant form in Escherichia coli allowing for their further evaluation against the individual sera. Among the antigens differentially recognized, Mpb70 and Mpb83 proteins stood out as potential correlates of protection offered b y vaccination with BCG Moreau, and vi were only recognized by individuals producing high levels of IFN γ . Additional studies are needed to determine the effective applicability of these antigens as potential correlates of protection provided by vaccination wi th BCG Moreau. This is the first report detailing the serologic recognition profile of individuals re-vaccinated with BCG Moreau against extracellular antigens of the homolo gous strain, and contributes to a better understanding of the Brazilian vaccine strai n against TB.
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El, Zant Samer. "Google matrix analysis of Wikipedia networks." Thesis, Toulouse, INPT, 2018. http://www.theses.fr/2018INPT0046/document.
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Cette thèse s’intéresse à l’analyse du réseau dirigé extrait de la structure des hyperliens de Wikipédia. Notre objectif est de mesurer les interactions liant un sous-ensemble de pages du réseau Wikipédia. Par conséquent, nous proposons de tirer parti d’une nouvelle représentation matricielle appelée matrice réduite de Google ou "reduced Google Matrix". Cette matrice réduite de Google (GR) est définie pour un sous-ensemble de pages donné (c-à-d un réseau réduit).Comme pour la matrice de Google standard, un composant de GR capture la probabilité que deux noeuds du réseau réduit soient directement connectés dans le réseau complet. Une des particularités de GR est l’existence d’un autre composant qui explique la probabilité d’avoir deux noeuds indirectement connectés à travers tous les chemins possibles du réseau entier. Dans cette thèse, les résultats de notre étude de cas nous montrent que GR offre une représentation fiable des liens directs et indirects (cachés). Nous montrons que l’analyse de GR est complémentaire à l’analyse de "PageRank" et peut être exploitée pour étudier l’influence d’une variation de lien sur le reste de la structure du réseau. Les études de cas sont basées sur des réseaux Wikipédia provenant de différentes éditions linguistiques. Les interactions entre plusieurs groupes d’intérêt ont été étudiées en détail : peintres, pays et groupes terroristes. Pour chaque étude, un réseau réduit a été construit. Les interactions directes et indirectes ont été analysées et confrontées à des faits historiques, géopolitiques ou scientifiques. Une analyse de sensibilité est réalisée afin de comprendre l’influence des liens dans chaque groupe sur d’autres noeuds (ex : les pays dans notre cas). Notre analyse montre qu’il est possible d’extraire des interactions précieuses entre les peintres, les pays et les groupes terroristes. On retrouve par exemple, dans le réseau de peintre sissu de GR, un regroupement des artistes par grand mouvement de l’histoire de la peinture. Les interactions bien connues entre les grands pays de l’UE ou dans le monde entier sont également soulignées/mentionnées dans nos résultats. De même, le réseau de groupes terroristes présente des liens pertinents en ligne avec leur idéologie ou leurs relations historiques ou géopolitiques.Nous concluons cette étude en montrant que l’analyse réduite de la matrice de Google est une nouvelle méthode d’analyse puissante pour les grands réseaux dirigés. Nous affirmons que cette approche pourra aussi bien s’appliquer à des données représentées sous la forme de graphes dynamiques. Cette approche offre de nouvelles possibilités permettant une analyse efficace des interactions d’un groupe de noeuds enfoui dans un grand réseau dirigéThis thesis concentrates on the analysis of the large directed network representation of Wikipedia.Wikipedia stores valuable fine-grained dependencies among articles by linking webpages togetherfor diverse types of interactions. Our focus is to capture fine-grained and realistic interactionsbetween a subset of webpages in this Wikipedia network. Therefore, we propose to leverage anovel Google matrix representation of the network called the reduced Google matrix. This reducedGoogle matrix (GR) is derived for the subset of webpages of interest (i.e. the reduced network). Asfor the regular Google matrix, one component of GR captures the probability of two nodes of thereduced network to be directly connected in the full network. But unique to GR, anothercomponent accounts for the probability of having both nodes indirectly connected through allpossible paths in the full network. In this thesis, we demonstrate with several case studies that GRoffers a reliable and meaningful representation of direct and indirect (hidden) links of the reducednetwork. We show that GR analysis is complementary to the well-known PageRank analysis andcan be leveraged to study the influence of a link variation on the rest of the network structure.Case studies are based on Wikipedia networks originating from different language editions.Interactions between several groups of interest are studied in details: painters, countries andterrorist groups. For each study, a reduced network is built, direct and indirect interactions areanalyzed and confronted to historical, geopolitical or scientific facts. A sensitivity analysis isconducted to understand the influence of the ties in each group on other nodes (e.g. countries inour case). From our analysis, we show that it is possible to extract valuable interactions betweenpainters, countries or terrorist groups. Network of painters with GR capture art historical fact sucha painting movement classification. Well-known interactions of countries between major EUcountries or worldwide are underlined as well in our results. Similarly, networks of terrorist groupsshow relevant ties in line with their objective or their historical or geopolitical relationships. Weconclude this study by showing that the reduced Google matrix analysis is a novel powerfulanalysis method for large directed networks. We argue that this approach can find as well usefulapplication for different types of datasets constituted by the exchange of dynamic content. Thisapproach offers new possibilities to analyze effective interactions in a group of nodes embedded ina large directed network
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Mattioli, Paolo. "Color/kinematic duality, double copies and scalar matrix models." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/5622/.
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In questa tesi presentiamo una descrizione autoconsistente della dualità Colore/Cinematica nelle teorie di gauge e al processo di Double Copy. Particolare attenzione viene data all'approccio alla dualità con il formalismo di cono-luce, in quanto semplifica notevolmente sia il calcolo sia l'interpretazione fisica: vengono indagati i settori duale e self-duale per poi passare al modello di Chalmers e Siegel per l'estensione alla teoria generale.
Proponiamo quindi uno Scalar Matrix Model, che può essere un buon modello per generare ampiezze ottenibili da una Double Copy `inversa', e ne studiamo un'eventuale dualità a la Colore/Cinematica. Vengono illustrati alcuni casi particolari di rottura spontanea di simmetria.
In appendice riportiamo un notebook di Mathematica per il calcolo di ampiezze tree level di puro gauge, utile per i calcoli necessari allo studio della dualità.
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Barrezueta, Luis Fernando Mesias [UNIFESP]. "Imuno-expressão das proteínas da família BCL-2 (BCL-2. BCL-XL, BAX, BAK, BAD) em câncer gátrico, preparados em arranjo em matriz (TMA)." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9724.
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Previous issue date: 2009-01-28Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Em casos de carcinoma gástrico, para contribuir ao conhecimento do processo de carcinogênese: Objetivo: Estudar a expressão das proteínas da família Bcl-2 (BcI-2, Bcl-xl, Bak, Bad, Bax). Correlacionar a expressão destas proteínas com 0 índice apoptótico mediante a expressão da proteína Caspase 3 clivada, com 0 índice mit6tico mediante a expressão da proteína Ki-67 e com a expressão da proteína p53. Método: Técnica de arranjo em matriz de amostras teciduais (TMA): em 87 amostras de adenocarcinomas gástricos (grupo teste) e de mucosa gástrica não tumoral (grupo controle) foi avaliada a imuno-expressão das proteínas da família BcI-2 (BeI-2, Bcl-xl, Bak, Bad, Bax), da proteína p53, da proteína caspase 3 e da proteína Ki-67. Resultados: Todas as proteínas examinadas foram observadas nos adenocarcinomas e mucosa não tumoral, porem com diferenças de expressão em relação à porcentagem de positividade e intensidade. Observamos: i) Houve associação entre 0 tamanho do tumor e a proteína p53. ii) Houve associação da proteína Bad no adenocarcinoma com a idade dos pacientes. iii) Associação das proteínas Bax, Bad e Ki-67 com 0 adenocarcinoma de tipo intestinal. iv) As proteínas Bcl-xl, Bak, Bad, p53 e Ki-67 apresentaram diferenças estatisticamente significantes entre a imuno-expressão no tumor e na mucosa não tumoral. v) Associação das proteínas Bax, Bak e Bad na mucosa não tumoral. vi) Não houve correlação da imunoexpressão das proteínas com a sobrevida dos pacientes. Conclusão: A expressão aumentada da proteína Bcl-xl nos adenocarcinomas, com evidente diferença de expressão entre 0 grupo teste e 0 grupo controle, esta relacionada com 0 efeito anti-apoptótico da proteína. A expressão reduzida das proteínas Bak e Bad e a expressão aumentada das proteínas p53 e Ki-67 nos adenocarcinomas demonstram 0 desequilíbrio entre morte e proliferação celular, permitindo 0 crescimento descontrolado das células neoplásicas.
Purpose: To study the immunoexpression of Bcl-2 family proteins (Bcl-2, Bcl-xl, Bax, Bak, Bad) and to evaluate the correlation between the immunoexpression of these proteins with the cleaved caspases 3, Ki-67 and p53 immuno-expression. Methods: A TMA paraffin block was constructed with gastric carcinoma tissue (test group) and normal gastric adjoining mucosa (control group) of 87 patients. The TMA block was submitted to immunohistochemistry for Bcl-2, Bcl-xl, Bax, Bak, Bad, p53 and-cleaved Caspase 3. Results: All studied proteins were present in tumor and normal gastric adjoining mucosa, but with different intensity and amount of positive cells. i) There was an association between tumor size and p53 expression. ii) association between Bad expression in the tumor and patient’s age. iii) Intestinal type adenocarcinoma was positively correlated with the expression of Bax, Bad and Ki-67. iv) The protein Bcl-xl, Bak, Bad, p53 and Ki-67 showed statistically significant differences between the immuno-expression in tumor and normal gastric adjoining mucosa. v) There was an association between the proteins Bax, Bak and Bad expression in the normal gastric adjoining mucosa. vi) No correlation between patient’s survival rates and the expression of the proteins was observed. Conclusions: The higher expression of Bcl-xl protein in adenocarcinoma, the difference of Bcl-xl expression between test group and control group, might be related with the anti-apoptotic effect of this protein. The lower expression of Bak and Bad and the increased expression of p53 protein and Ki-67 protein in adenocarcinomas demonstrate the imbalance between death and cellular proliferation, which allows the uncontrolled tumor cell proliferation.
FAPESP: 04/09932-4
FAPESP: 06/54187-0
TEDE
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Hudson, Shane Lee. "A qualitative study of the performance diagnosis matrix at the individual level as a predictor of student-athlete success as identified by Division IA coaches in the Big 12 Conference." Texas A&M University, 2002. http://hdl.handle.net/1969.1/5897.
Full textAbstract:
The intent of this study was to determine if menâÂÂs football and menâÂÂs
basketball coaches at the university or college level utilize an assessment
instrument when recruiting and evaluating potential student-athletes. Specifically
studied through interviews were the characteristics that these coaches look for in
successful and unsuccessful student-athletes, how they currently collect
information during the recruitment period and the importance of collecting data on
student-athletes. SwansonâÂÂs Performance Diagnosis Matrix and Human Capital
Theory framed the research. The population for this study consisted of current
Division IA menâÂÂs football and menâÂÂs basketball coaches in the Big 12 Conference.
Prior to contacting the Big 12 coaches a pilot study was conducted at two Division
IA Universities and with a former head football coach at a Big 12 Conference
University. These interviews were instrumental in the final development of the
questions used to interview the Big 12 Conference coaches. The participants were
sent a letter asking for their participation in the study and then were contacted by phone to set up an interview. The interviews were conducted in the months of July,
August, and September 2006 by phone. This study found that most coaches do not
have or utilize an assessment instrument. Significant data showed coaches believe
that the evaluation process of student-athletes is the most difficult and critical part
of their job. Using emergent category designation I found seven themes
(characteristics) of successful student-athletes, as indicated by the coaches:
competitive, a hard worker, has a supportive family, is a leader, has good character,
and is honest. I also found the themes (characteristics) of an unsuccessful student-athlete
to be: undisciplined, lacks character, has an unstable family and is not
competitive. The study helps to define through research and development an
assessment instrument to more effectively define the needs of student-athletes prior
to entering universities and coaches will have additional data for meeting the needs
of student-athletes.
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Semeraro, Angelo. "Cenni al modello del Big Bang, inflazione e materia oscura." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/19999/.
Full text
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Evola, Chiara. "Cenni al modello del Big Bang, inflazione e materia oscura." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19481/.
Full textAbstract:
Questo elaborato vuole offrire un riassunto del modello del Big Bang, della materia oscura e del Modello Cosmologico Standard, come conseguenza dei primi due.
La cosmologia è la scienza che studia l’Universo nel suo insieme, la sua formazione, la sua evoluzione e il suo destino futuro.
Partendo dalle scoperte osservative, che hanno permesso la teorizzazione dell'espansione dell'Universo, Lemaȋtre, nel secolo scorso, getta le basi per il primo modello del Big Bang. Quest'ultimo mira a spiegare come si sia generato il nostro Universo. Nel tempo i cosmologi hanno reso il modello sempre più complesso e accurato, anche grazie alle numerose scoperte astronomiche dell'ultimo secolo.
Tra queste scoperte c'è la materia oscura, un elemento fondamentale del nostro Universo, e uno dei dilemmi più grandi dell'astrofisica dei nostri giorni. All’interno di questo elaborato ne è illustrato il percorso storico, tra le osservazioni e le ipotesi legate alla sua origine e alla sua composizione.
Infine, viene accennato il Modello Cosmologico Standard e i suoi parametri. Il modello che ad oggi è accettato dalla comunità scientifica.
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Mauro, Federica. "Cenni al modello del Big Bang, inflazione e materia oscura." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21234/.
Full textAbstract:
Lo scopo dell'elaborato è quello di fornire una trattazione generale sul modello del Big Bang, sul modello cosmologico e sulla materia oscura. La cosmologia si occupa della struttura e dell'evoluzione del cosmo, cercando di risalirne alle origini e si è cominciata ad imporre come scienza grazie alle scoperte astronomiche del secolo scorso. Partendo dal concetto di redshift, i lavori di Edwin Hubble e Georges Lemaître sulle velocità di recessione delle galassie, hanno portato a parlare di espansione dell'universo. Tra le teorie circa l'origine dell'universo si è affermata quella del Big Bang, che è la più accreditata dai dati osservativi quali il problema dell’elio con la nucleosintesi primordiale, la scoperta della radiazione cosmica di fondo CMB e la teoria dell’inflazione. Nel corso degli ultimi anni il modello cosmologico è diventato sempre più complesso ed accurato anche alla base delle nuove scoperte. Nell'elaborato si mettono in evidenza i modelli cosmologici possibili dandone sia una trattazione geometrica con le equazioni di Newton, sia una qualitativa in termini di densità di materia ed e energia con le equazioni di Friedmann. Ci si concentra maggiormente sul modello cosmologico standard, quello attualmente adottato, per il quale i contributi principali sono quelli di un’energia e di una materia oscura che ad oggi rappresentano uno degli interrogativi più grandi legati al nostro universo. Alla materia oscura è dedicata la parte finale tramite un percorso storico con i calcoli legati alla sua ipotesi e il dettaglio della sua interazione gravitazionale con la materia ordinaria che ne ha confermato la presenza.
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Pacini, Bianca. "Cenni al modello del Big Bang, inflazione e materia oscura." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/22220/.
Full textAbstract:
Nell'elaborato si cerca di fornire una visione d'insieme del modello cosmologico del Big Bang, come esso nasce e le problematiche associate; si fa riferimento all'inflazione in quanto soluzione a tre problemi principali. Per fare questo si introducono le equazioni di campo di Einstein dalle quali si ricavano le equazioni di Friedmann, che descrivono l'evoluzione dell'universo. Tramite esse, specificando una particolare equazione di stato, si ricava l'evoluzione temporale delle diverse componenti dell'universo. Nell'ambito del modello del Big Bang si dà anche una spiegazione qualitativa e sintetica della CMB, che sarà citata più volte nella trattazione. Infine si propone una discussione riguardante la materia oscura, costituente fondamentale dell'universo, di cui ancora la natura non è nota.
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Raso, Silvia. "Cenni al modello del Big Bang, inflazione e materia oscura." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7381/.
Full textAbstract:
La cosmologia ha come scopo lo studio di origine ed evoluzione dell’Universo, per averne una comprensione generale attraverso le leggi fisiche conosciute.
Il modello del Big Bang, di cui si dà la descrizione teorica nel capitolo 1, è una delle formulazioni più recenti di teoria che mira a spiegare l’inizio e la successiva evoluzione dell’Universo, fino ad avanzare anche ipotesi sul suo destino futuro; è inoltre il modello generalmente accettato dalla comunità scientifica in quanto, di tutti i modelli proposti nel corso degli anni, è quello con più riscontri sperimentali e che meglio si trova in accordo con le osservazioni.
I principali successi del modello vengono trattati nel capitolo 2. In particolare: si tratterà di redshift e legge di Hubble, collegati all’espansione dell’Universo, importante prova dell’attendibilità del modello del Big Bang; della radiazione cosmica di fondo, scoperta negli anni ’60 quasi per caso e poi ricondotta a ipotesi teoriche già avanzate anni prima nelle prime formulazioni del modello; della nucleosintesi primordiale, che spiega l’abbondanza attuale dei principali costituenti dell’Universo, H ed He, cosa che altrimenti non sarebbe spiegabile se si considerasse soltanto la formazione di tali elementi nelle stelle.
Ovviamente anche questo modello, come si vede nel capitolo 3, non manca di problemi, a cui si è trovata una risoluzione parziale o comunque non definitiva; in questa sede tuttavia, per ragioni di spazio, tali problemi e la loro soluzione verranno soltanto accennati. Si accennerà al problema dell’Universo piatto e al problema dell’orizzonte, e a come essi possano essere spiegati introducendo il concetto di inflazione.
Infine, nel capitolo 4, si accenna anche alla materia oscura, soprattutto per quanto riguarda le evidenze sperimentali che ne hanno permesso la scoperta e le prove successive che ne confermano l’esistenza. Tuttora ne ignoriamo natura e composizione, visto che a differenza della materia ordinaria non emette radiazione elettromagnetica, ma i suoi effetti gravitazionali sono evidenti ed è estremamente difficile che la sua esistenza possa essere messa in discussione.
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Caccia, Riccardo. "Cenni al modello del big bang, inflazione e materia oscura." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7805/.
Full textAbstract:
Il presente lavoro intende offrire un riassunto dello “stato dell’arte” della Cosmologia: dopo averne ripercorso per sommi capi la storia degli ultimi cent’anni (cap.1), verrà illustrato il Modello Cosmologico Standard “ΛCDM” (cap.2), che è quello generalmente accettato dalla comunità scientifica allo stato attuale delle conoscenze; infine, si farà un breve “excursus” sulle questioni “aperte” e sui modelli cosmologici alternativi (cap.3).
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Fedi, Francesca. "Cenni al modello del Big Bang, Inflazione e materia oscura." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amslaurea.unibo.it/25268/.
Full textAbstract:
Questo elaborato ha lo scopo di fornire una panoramica sulle principali teorie che hanno portato allo sviluppo della concezione di universo, ad oggi maggiormente accettata. Espone inoltre le principali osservazioni astrofisiche che sono state necessarie alla comprensione della struttura dell’universo, fino ad arrivare a problemi ancora oggi aperti e dibattuti.
Nel primo capitolo si espone il lavoro che ha portato alla formulazione della legge di espansione dell’universo e successivamente alla teoria del Big Bang.
Nel secondo capitolo vengono descritte le primissime fasi di vita dell’universo, la teoria dell’inflazione e la radiazione cosmica di fondo.
Nel terzo capitolo si introduce il Modello Cosmologico Standard che, oltre alla materia barionica, prevede anche la presenza della materia oscura.
Il quarto capitolo si concentra sulla materia oscura e sulla sua possibile composizione, sulle curve di rotazione delle galassie a spirale e sulle lenti gravitazionali.
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Ткаченко, Л. Р. "Міжнародна конкурентоспроможність підприємств морської транспортної галузі (на прикладі ДП «МТП «Южний»)." Thesis, Одеський національний економічний університет, 2021. http://local.lib/diploma/Tkachenko.pdf.
Full textAbstract:
Доступ до роботи тільки на території бібліотеки ОНЕУ, для переходу натисніть на посилання нижчеУ роботі розглядаються теоретико-методичні основи дослідження міжнародної конкурентоспроможності підприємств морської транспортної галузі. Досліджено чинники впливу на стан та розвиток міжнародної конкурентоспроможності підприємств морської транспортної галузі та систематизовано методи оцінки міжнародної конкурентоспроможності підприємства. Проаналізовано показники обсягів, динаміки та структури міжнародних вантажлперевезень ДП «МТП «Южний». Проведено SWOT- та PEST - аналіз. Визначені фактори впливу внутрішнього та зовнішнього середовища на міжнародну конкурентоспроможність ДП «МТП «Южний». Проведена оцінка сучасного стану міжнародної конкурентоспроможності ДП «МТП «Южний». Запропоновано шляхи підвищення міжнародної конкурентоспроможності ДП «МТП «Южний» за рахунок участі підприємства у створенні морського мультимодального кластеру. Особливий наголос зроблено на удосконаленні ДП «МТП «Южний» інноваційно-інвестиційного розвитку як чинника підвищення міжнародної конкурентоспроможності.
The paper considers the theoretical and methodological foundations of the study of the international competitiveness of maritime transport enterprises. The factors influencing the state and development of the international competitiveness of the enterprises of the maritime transport branch are investigated and the methods of assessing the international competitiveness of the enterprise are systematized. Indicators of volumes, dynamics and structure of international freight transportation of Sea Commercial Port “Yuzhny” are analyzed. SWOT and PEST analysis was performed. Factors influencing the internal and external environment on the international competitiveness of Sea Commercial Port “Yuzhny” have been identified. An assessment of the current state of international competitiveness of the of Sea Commercial Port “Yuzhny”was carried out. Ways to increase the international competitiveness of Sea Commercial Port “Yuzhny” through the participation of the company in the creation of a maritime multimodal cluster. Special emphasis was placed on the improvement of Sea Commercial Port “Yuzhny” innovation and investment development as a factor in increasing international competitiveness.
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Cui, Wenping. "Statistical Mechanics of Microbiomes:." Thesis, Boston College, 2021. http://hdl.handle.net/2345/bc-ir:109135.
Full textAbstract:
Thesis advisor: Pankaj MehtaThesis advisor: Ziqiang Wang
Nature has revealed an astounding degree of phylogenetic and physiological diversity in natural environments -- especially in the microbial world. Microbial communities are incredibly diverse, ranging from 500-1000 species in human guts to over 1000 species in marine ecosystems. Historically, theoretical ecologists have devoted considerable effort to analyzing ecosystems consisting of a few species. However, analytical approaches and theoretical insights derived from small ecosystems consisting of a few species may not scale up to diverse ecosystems. Understanding such large complex ecosystems poses fundamental challenges to current theories and analytical approaches for modeling and understanding the microbial world. One promising approach for tackling this challenge that I develop in my thesis is to adapt and expand ideas from statistical mechanics to theoretical ecology. Statistical mechanics has helped us to understand how collective behaviors emerge from the interaction of many individual components. In this thesis, I present a unified theoretical framework for understanding complex ecosystems based on statistical mechanics, random matrix theories, and convex optimization. My thesis work has three key aspects: modeling, simulations, and theories. Modeling: Classical ecological models often focus on predator-prey relationships. However, this is not the norm in the microbial world. Unlike most macroscopic organisms, microbes relie on consuming and producing small organic molecules for energy and reproduction. In this thesis, we develop a new Microbial Consumer Resource Model that takes into account these types of metabolic cross-feeding interactions. We demonstrate that this model can qualitatively reproduce and explain statistical patterns observed in large survey data, including Earth Microbiome Project and the Human Microbiome Project. Simulations: Computational simulations are essential in theoretical ecology. Complex ecological models often involve ordinary differential equations (ODE) containing hundreds to thousands of interacting variables. Typical ODE solvers are based on numerical integration methods, which are both time and resource intensive. To overcome this bottleneck, we derived a surprising duality between constrained convex optimization and generalized consumer-resource models describing ecological dynamics. This allows us to develop a fast algorithm to solve the steady-state of complex ecological models. This improves computational performance by between 2-3 orders of magnitude compared to direct numerical integration of the corresponding ODEs. Theories:Few theoretical approaches allow for the analytic study of communities containing a large number of species. Recently, there has been considerable interest in the idea that ecosystems can be thought of as a type of disordered systems. This mapping suggests that understanding community coexistence patterns is actually a problem in "spin-glass'' physics. This has motivated physicists to use insights from spin glass theory to uncover the universal features of complex ecosystems. In this thesis, I use and extend the cavity method, originally developed in spin glass theories, to answer fundamental ecological questions regarding the stability, diversity, and robustness of ecosystems. I use the cavity method to derive new species backing bounds and uncover novel phase transitions to typicality
Thesis (PhD) — Boston College, 2021
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Physics
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Радченко, О. О. "Стан та перспективи підвищення міжнародної конкурентоспроможності виноробного підприємства (на прикладі ТОВ «Винхол Оксамитне»)." Thesis, Одеський національний економічний університет, 2021. http://local.lib/diploma/Radchenko.pdf.
Full textAbstract:
Доступ до роботи тільки на території бібліотеки ОНЕУ, для переходу натисніть на посилання нижчеУ роботі розглядаються теоретико-методичні основи дослідження міжнародної конкурентоспроможності виноробного підприємства. Досліджено чинники впливу на міжнародну конкурентоспроможність виноробного підприємства та систематизовано методи оцінки міжнародної конкурентоспроможності виноробного підприємства. Проаналізовано показники сучасного стану та динаміки експорту виноробної продукції ТОВ «Винхол Оксамитне». Проведено SWOT- та PEST - аналіз. Визначені чинники впливу на міжнародну конкурентоспроможність ТОВ «»Винхол Оксамитне». Проведена оцінка стану міжнародної конкурентоспроможності ТОВ «Винхол Оксамитне». Запропоновано напрями підвищення міжнародної конкурентоспроможності ТОВ «Винхол Оксамитне» за рахунок диверсифікації виробництва, диверсифікації ринків збуту, отримання географічної прив’язки. Особливий наголос зроблено на необхідності участі ТОВ «Винхол Оксамитне» у створенні виноградарсько-виноробного кластеру в Одеській області.
The paper considers the theoretical and methodological foundations of the study of the international competitiveness of the winery. The factors influencing the international competitiveness of the winery are investigated and the methods of assessing the international competitiveness of the winery are systematized. Indicators of the current state and dynamics of exports of wine products of LLC " Vinehall Velvet" are analyzed. SWOT and PEST analysis was performed. Factors influencing the international competitiveness of Vinehall Velvet LLC have been identified. An assessment of the state of international competitiveness of Vinehall Velvet LLC was conducted. The directions of increase of the international competitiveness of " Vinehall Velvet LLC" at the expense of diversification of manufacture, diversification of the markets, reception of geographical reference are offered. Particular emphasis was placed on the need for participation of Vinehall Velvet LLC in the creation of a viticulture and wine cluster in the Odessa region.
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Isola, Monica. "Does the Matrix Matter? A Comparison on Phenology and Habitat utilization of Two Treefrog Species in the Big Cypress National Preserve." FIU Digital Commons, 2011. http://digitalcommons.fiu.edu/etd/509.
Full textAbstract:
Habitat loss and fragmentation are some of the causes of biodiversity decline. Naturally fragmented landscapes serve as analogues to anthropogenically fragmented landscapes. Recent studies have shown that the matrix between patches has an important role in the dynamics of patch-dwelling species. I studied phenology and habitat utilization of Hyla cinerea and Hyla squirella, the two most common yet understudied frogs, in two patchy landscapes of the Big Cypress National Preserve. Frogs were sampled in five domes and in their adjacent matrix, monthly, between 2006 and 2008. Using nighttime visual encounter surveys, specimens encountered were identified to species, and perch type, perch height and capture location were recorded. Analysis showed differences in abundance and habitat use patterns between patches and matrices for the two species across the two landscapes. These differences indicate that the matrix is important in shaping patterns of abundance and habitat use in fragmented landscapes.
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Coquidé, Célestin. "Analyse de réseaux complexes réels via des méthodes issues de la matrice de Google." Thesis, Bourgogne Franche-Comté, 2020. http://www.theses.fr/2020UBFCD038.
Full textAbstract:
Dans une époque où Internet est de plus en plus utilisé et où les populations sont de plus en plus connectées à travers le monde, notre vie quotidienne est grandement facilitée. Un domaine scientifique très récent, la science des réseaux, dont les prémices viennent des mathématiques et plus précisément de la théorie des graphes a justement pour objet d'étude de tels systèmes complexes. Un réseau est un objet mathématique fait de nœuds et de connexions entre ces nœuds. Dans la nature, on retrouve une multitude de phénomènes pouvant être vus ainsi, par exemple, le mycélium qui est un réseau souterrain capable d'avoir accès à courtes et moyennes distances aux ressources organiques propices à sa survie, ou bien encore le réseau vasculaire sanguin. À notre échelle, il existe aussi des réseaux dont nous sommes les nœuds. Dans cette thèse, nous allons nous intéresser aux réseaux réels, réseaux construits à partir de banques de données, afin de les analyser, puis d'extraire des informations difficilement accessibles dans des réseaux pouvant contenir, parfois, des millions de nœuds et cent fois plus de connexions. Les réseaux étudiés sont aussi dirigés, autrement dit, les liens ont une direction. On représente une marche aléatoire dans un tel réseau à l'aide d'une matrice stochastique appelée matrice de Google. Elle permet notamment de mesurer l'importance des nœuds d'un réseau à l'aide de son vecteur propre dominant, le vecteur PageRank. À partir de la matrice de Google, nous pouvons aussi construire une matrice de Google de taille réduite représentant toutes les connexions entre les éléments d'un sous-réseau d'intérêt, le réseau réduit, mais aussi et surtout de pouvoir quantifier les connexions indirectes entre ces nœuds, obtenues par diffusion à travers tout le reste du réseau. Cette matrice de Google réduite permet, en plus de réduire considérablement la taille du réseau et de la matrice de Google associée, d'extraire des liens indirects non-triviaux entre les nœuds d'intérêts, appelés liens cachés. À l'aide d'outils construits à partir de la matrice de Google, notamment la matrice de Google réduite, nous allons, à travers le réseau Wikipédia, identifier les interactions entre les universités et leurs influences sur le monde, et utiliser des données de comportements utilisateurs Wikipédia afin de mesurer les tendances culturelles actuelles. À partir de réseaux économiques, nous allons mesurer la résistance économique de l'Union européenne face à une hausse des prix liés au pétrole et au gaz extérieurs, mais aussi établir les interdépendances entre secteurs de production propres à quelques puissances économiques comme les États-Unis ou encore la Chine. Enfin, nous allons établir un modèle de propagation de crise économique et l'appliquer au réseau du commerce international et au réseau de transactions de BitcoinIn a current period where people use more and more the Internet and are connected worldwide, our lives become easier. The Network science, a recent scientific domain coming from graph theory, handle such connected complex systems. A network is a mathematical object consisting in a set of interconnected nodes and a set of links connecting them. We find networks in nature such as networks of mycelium which grow underground and are able to feed their cells with organic nutrients located at low and long range from them, as well as the circulation system transporting blood throughout the human body. Networks also exist at a human scale where humans are nodes of such networks. In this thesis we are interested in what we call real complex networks which are networks constructed from databases. We can extract information which is normally hard to get since such a network might contain one million of nodes and one hundred times more links. Moreover, networks we are going to study are directed meaning that links have a direction. One can represent a random walk through a directed network with the use of the so-called Google matrix. The PageRank is the leading eigenvector associated to this stochastic matrix and allows us to measure nodes importance. We can also build a smaller Google matrix based on the Google matrix and a subregion of the network. This reduced Google matrix allows us to extract every existing links between the nodes composing the subregion of interest as well as all possible indirect connections between them by spreading through the entire network. With the use of tools developed from the Google matrix, especially the reduced Google matrix, considering the network of Wikipedia's articles we have identified interactions between universities of the world as well as their influence. We have extracted social trends by using data related to actual Wikipedia's users behaviour. Regarding the World Trade Network, we were able to measure economic response of the European Union to external petroleum and gas price variation. Regarding the World Network of economical activities we have figured out interdependence of sectors of production related to powerhouse such as The United States of America and China. We also built a crisis contagion model we applied on the World Trade Network and on the Bitcoin transactions Network
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Lugato, Alfredo Minuci. "A colonialidade do poder do mercado : a soberania brasileira diante das agências de classificação de risco de crédito /." Franca, 2019. http://hdl.handle.net/11449/182187.
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Orientador: Murilo GaspardoResumo: Este trabalho objetiva investigar como a “colonialidade do poder” do mercado de classificação de risco de crédito limita a soberania brasileira, e a existência ou não de alternativas institucionais que possam contribuir para o enfrentamento desta questão. Para tanto, estuda de que modo as Três Grandes contaram com o domínio econômico e político dos Estados Unidos para se consolidarem no domínio do mercado, e como seus saberes impactam o preço dos ativos no mercado financeiro, configurando suas “autoridades epistêmicas”. Posteriormente, examina de que maneira seus saberes apresentam semelhanças prejudiciais ao Brasil e a outros países subdesenvolvidos em, pelo menos, dois campos: teto e rating soberanos. Dessa forma, analisa como há um enredamento entre domínio econômico-político e epistêmico, característicos da “matriz colonial de poder”, que limita ainda mais a soberania do Brasil e de outros países subdesenvolvidos, além de prejudicar seus “fins” de Estado. Diante desse quadro, pesquisa alternativas institucionais disponíveis ao país para lidar com esse assunto e com outros problemas da ordem econômica atual.
Abstract: This paper aims to investigate how the credit rating market’s “coloniality of power” limits the brazilian sovereignty, and the existence or not of institutional alternatives that might contribute to face this issue. In order to achieve this, it studies how the Big Three counted on the United States’ economic and political domination to consolidate their market’s domination, and how their knowledges impact assets prices on financial market, settling their “epistemic authorities”. Afterwards, it examines how their knowledges present harmful similiarities to Brazil and other developing countries on, at least, two fieds: sovereign ceiling and rating. Thus, it analyzes how there is an entanglement between economic-political and epistemic domination, typical from “colonial matrix of power”, that limits even more the sovereignty of Brazil and other underdeveloped countries, aside from prejudicing its State’s “ends”. Before this framework, it searches for available institutional alternatives for Brazil to cope with this issue and other problems of the current economic order.
Mestre
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Männel, Michael. "Condensation phenomena in interacting Fermi and Bose gases." Doctoral thesis, Universitätsbibliothek Chemnitz, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-77738.
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In dieser Dissertation werden das Anregungsspektrum und das Phasendiagramm wechselwirkender Fermi- und Bosegase untersucht. Zu diesem Zweck wird eine neuartige renormierte Kadanoff-Martin-Näherung vorgestellt, die Selbstwechselwirkung von Teilchen vermeidet und somit eine einheitliche Beschreibung sowohl der normalen als auch der kondensierten Phase ermöglicht. Für Fermionen findet man den BCS-Zustand, benannt nach Bardeen, Cooper und Schrieffer, welcher entscheidend ist für das Phänomen der Supraleitung. Charakteristisch für diesen Zustand ist eine Energielücke im Anregungsspektrum an der Fermi-Energie. Weiterhin tritt für Bosonen eine Bose-Einstein-Kondensation (BEC) auf, bei der das Anregungsspektrum für kleine Impulse linear ist. Letzteres führt zum Phänomen der Suprafluidität. Über die bereits bekannten Phänomene hinaus findet man eine dem BCS-Zustand ähnliche Kondensation von Zweiteilchenbindungszuständen, sowohl für Fermionen als auch für Bosonen. Für Fermionen tritt ein Übergang zwischen der Kondensation von Bindungszuständen und dem BCS-Zustand auf, der sogenannte BEC-BCS-Übergang. Die Untersuchung der Zustandsgleichung zeigt, dass im Gegensatz zu Fermi-Gasen und Bose-Gasen mit abstoßender Wechselwirkung Bose-Gase mit anziehender Wechselwirkung zu einer Flüssigkeit kondensieren oder sich verfestigen, bevor es zur Kondensation von Bindungszuständen oder zur Bose-Einstein-Kondensation kommt. Daher können diese Phänomene voraussichtlich nicht in der Gasphase beobachtet werden. Zusammenfassend lässt sich sagen, dass das vorgestellte Näherungsverfahren sehr gut geeignet ist, die erwähnten Phänomene im Zusammenhang mit der Bose-Einstein-Kondensation zu beschreiben.
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Dahlin, Mathilda. "Avkodning av cykliska koder - baserad på Euklides algoritm." Thesis, Karlstads universitet, Institutionen för matematik och datavetenskap (from 2013), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-48248.
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Today’s society requires that transformation of information is done effectively and correctly. In other words, the received message must correspond to the message being sent. There are a lot of decoding methods to locate and correct errors. The main purpose in this degree project is to study one of these methods based on the Euclidean algorithm. Thereafter an example will be illustrated showing how the method is used when decoding a three - error correcting BCH code. To begin with, fundamental concepts about coding theory are introduced. Secondly, linear codes, cyclic codes and BCH codes - in that specific order - are explained before advancing to the decoding process. The results show that correcting one or two errors is relatively simple, but when three or more errors occur it becomes much more complicated. In that case, a specific method is required.Dagens samhälle kräver att informationsöverföring sker på ett effektivt och korrekt sätt, det vill säga att den information som når mottagaren motsvarar den som skickades från början. Det finns många avkodningsmetoder för att lokalisera och rätta fel. Syftet i denna uppsats är att studera en av dessa, en som baseras på Euklides algoritm och därefter illustrera ett exempel på hur metoden används vid avkodning av en tre - rättande BCH - kod. Först ges en presentation av grunderna inom kodningsteorin. Sedan introduceras linjära koder, cykliska koder och BCH - koder i nämnd ordning, för att till sist presentera avkodningsprocessen. Det visar sig att det är relativt enkelt att rätta ett eller två fel, men när tre eller fler fel uppstår blir det betydligt mer komplicerat. Då krävs någon speciell metod.
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Zerbib, Romain. "L'influence du discours des cabinets de conseil dans la diffusion d'une pratique de gestion : le cas de la matrice BCG aux Etats-Unis entre 1969 et 1981." Angers, 2011. https://tel.archives-ouvertes.fr/tel-01131309.
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S’il est un secteur où l’on observe une intense volonté de peser sur son environnement c’est, en partie, celui qu’occupent les multinationales du conseil en stratégie. Ces dernières s’efforcent de dominer le théâtre des luttes concurrentielles en imposant de nouvelles pratiques de gestion sur le marché. Elles généralisent de nouvelles doctrines managériales qui démantèlent le bien-fondé des pratiques établies et imposent l’usage de dispositifs adaptés, en l’occurrence les leurs. Cette thèse examine ces manoeuvres de formatage et propose un dispositif discursif à même de favoriser la diffusion d’une pratique de gestion. La théorie néo-institutionnelle et la théorie des modes managériales soulignent que les managers adoptent une pratique en fonction de critères d’ordre « technico-économiques » mais également « socio-psychologiques ». Notre dispositif discursif s’appuie sur ces deux moteurs d’adoption. Il vise à présenter une pratique comme étant simple et efficace pour répondre aux besoins « technico-économiques » des managers mais également moderne et rationnelle pour répondre à leurs attentes d’ordres « sociopsychologiques ». Un test empirique démontre que cette approche discursive pousse 85% des managers interrogés à adopter le modèle FRE, une pratique fictive dont les défauts majeurs sont facilement identifiablesAn intense will to influence its environment can be noted particularly in the multinational consulting firms’ sector. These companies try hard to dominate high competitive markets by imposing their new practices. They generalize new managerial doctrines which dismantle the legitimacy of the established practices and require using adapted devices, in other words, theirs. This thesis examines these operations of orientation and proposes a discursive model able to enhance the diffusion of a management practice. The neo-institutional and fashion management theories highlight the fact that managers adopt a practice according to “technico-economic” but also “sociopsychological”criteria. Our model is based on these both adoption motives. It suggests introducing a practice as simple and efficient in order to meet the managers’ “technicoeconomic” needs, but also as modern and rational in order to meet their “sociopsychological” expectations. An empirical test shows this discursive approach brings 85% of the managers interviewed to adopt the FRE model, a fictitious practice with major defects easily recognizable
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Oh, Jae-Hyuk. "GAUGE-GRAVITY DUALITY AND ITS APPLICATIONS TO COSMOLOGY AND FLUID DYNAMICS." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/178.
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This thesis is devoted to the study of two important applications of gauge-gravity duality: the cosmological singularity problem and conformal fluid dynamics. Gauge-gravity duality is a concrete dual relationship between a gauge theory (such as electromagnetism, the theories of weak and strong interactions), and a theory of strings which contains gravity. The most concrete application of this duality is the AdS/CFT correspondence, where the theory containing gravity lives in the bulk of an asymptotically anti-de-Sitter space-time, while the dual gauge theory is a deformation of a conformal field theory which lives on the boundary of anti-de-Sitter space-time(AdS).
Our first application of gauge-gravity duality is to the cosmological singularity problem in string gravity. A cosmological singularity is defined as a spacelike region of space-time which is highly curved so that Einstein’s gravity theory can be no longer applied. In our setup the bulk space-time has low curvature in the far past and the physics is well described by supergravity (which is an extension of standard Einstein gravity). The cosmological singularity is driven by a time dependent string coupling in the bulk theory. The rate of change of the coupling is slow, but the net change of the coupling can be large. The dual description of this is a time dependent coupling of the boundary gauge theory. The coupling has a profile which is a constant in the far past and future and attains a small but finite value at intermediate times. We construct the supergravity solution, with the initial condition that the bulk space-time is pure AdS in the far past and show that the solution remains smooth in a derivative expansion without formation of black holes. However when the intermediate value of the string coupling becomes weak enough, space-time becomes highly curved and the supergravity approximation breaks down, mimicking a spacelike singularity. The resulting dynamics is analyzed in the dual gauge theory with a time dependent coupling constant which varies slowly. We develop an appropriate adiabatic expansion in the gauge theory in terms of coherent states and show that the time evolution continues to be smooth. We cannot, however, arrive at a definitive conclusion about the fate of the system at very late times when the coupling has again risen and supergravity again applies. One possibility is that the energy which has been supplied to the universe is simply extracted out and the space-time goes back to its initial state. This could provide a model for a bouncing cosmology. A second possibility is that dissipation leads to a thermal state at late time. If this possibility holds, we show that such a thermal state will be described either by a gas of strings or by a small black hole, but not by a big black hole. This means that in either case, the future space-time is close to AdS.
We then apply gauge-gravity duality to conformal fluid dynamics. The long wavelength behavior of any strongly coupled system with a finite mean free path is described by an appropriate fluid dynamics. The bulk dual of a fluid flow in the boundary theory is a black hole with a slowly varying horizon. In this work we consider certain fluid flows which become supersonic in some regions. It is well known that such flows present acoustic analogs of ergoregions and horizons, where acoustic waves cannot propagate in certain directions. Such acoustic horizons are expected to exhibit thermal radiation of acoustic waves with temperature essentially given by the gradient of the velocity at the acoustic horizon. We find acoustic analogs of black holes in charged conformal fluids and use gauge-gravity duality to construct dual gravity solutions. A certain class of gravitational quasinormal wave modes around these gravitational backgrounds perceives a horizon. Upon quantization, this implies that these gravitational modes should have a thermal spectrum.
The final issue that we study is fluid-gravity duality at zero temperature. The usual way of constructing gravity duals of fluid flows is by means of a small derivative expansion, in which the derivatives are much smaller than the temperature of the background black hole. Recently, it has been reported that for charged fluids, this procedure breaks down in the zero temperature limit. More precisely, corrections to the small derivative expansion in the dual gravity of charged fluid at zero temperature have singularities at the black hole horizon. In this case, fluid-gravity duality is not understood precisely. We explore this problem for a zero temperature charged fluid driven by a low frequency, small amplitude and spatially homogeneous external force. In the gravity dual, this force corresponds to a time dependent boundary value of the dilaton field. We calculate the bulk solution for the dilaton and the leading backreaction using a modified low frequency expansion. The resulting solutions are regular everywhere, establishing fluid-gravity duality to this order.
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Dube, Admire. "The design, preparation and evaluation of Artemisia Afra and placebos in tea bag dosage form suitable for use in clinical trials." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2915_1188480959.
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Artemisia Afra, a popular South African traditional herbal medicine is commonly administered as a tea infusion of the leaves. However, clinical trials proving it safety and efficacy are lacking mainly due to the absence of good quality dosage forms and credible placebos for the plant. The objectives of this study were to prepare a standardized preparation of the plant leaves and freeze-dried aqueous extract powder of the leaves, in a tea bag dosage form and to design and prepare credible placebos for these plant materials.
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Taddei, Fabio. "Spin-polarized transport in superconducting and ferromagnetic nanostructures." Thesis, Lancaster University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369499.
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Puissant, Alexandre. "Exploration des mécanismes de résistance aux inhibiteurs de BCR-ABL dans la leucémie myéloïde chronique : cibler l'autophagie pour ouvrir la voie à de nouvelles stratégies anti-leucémiques." Nice, 2010. http://www.theses.fr/2010NICE4048.
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La leucémie myéloïde chronique (LMC) est un syndrome myéloprolifératif malin lié à l’acquisition d’une anomalie génétique au sein d’une cellule souche myléoïde. Cette anomalie nommé chromosome Philadelphie résulte d’une translocation t(9 ;22) codant pour la protéine de fusion p210BCR-ABL à activité tyrosine kinase constitutive nécessaire et suffisante pour engendrer la pathologie. Le traitement de référence de la LMC repose sur l’utilisation du Glivec, un inhibiteur de BCR-ABL qui constitue un parfait exemple de thérapie ciblée. Bien que ce traitement soit très efficace, encore 20 % des patients développent des résistances à cette thérapie dont les mécanismes moléculaires ne sont que partiellement connus. Ces mécanismes de résistance peuvent être dépendants ou indépendant de BCR-ABL. Alors que les résistances dépendantes de BCR-ABL ont été très largement décrites, celles indépendantes de BCR-ABL, qui touchent 40% environ des patients résistants ne sont pas encore totalement élucidées. Il est donc important de mieux comprendre ces processus, afin d’établir de nouvelles stratégies thérapeutiques pour les contrecarrer. Un premier axe de mon projet de thèse a consisté à déterminer de nouveaux mécanismes de résistance à l’imatinib et, de manière plus générale, aux inhibiteurs de BCR-ABL. A partir d’une lignée K562 de LMC( IM-S), nous avons dérivé des clones résistants à l’imatinib (IM-R). Grâce à une analyse par biopuces à ADN, nous avons identifié 30 gènes significativement surexprimés dans les cellules IM-R par rapport à la lignée K562 parentale. Nous avons établi, par une approche fonctionnelle, que l’activation exacerbée de la Scr kinase Fyn conduit, via la voie ERK1/2, à la surexpression de la protéine matricellulaire SPARC impliquée dans la résistance des cellules IM-R De manière intéressante, une très faible proportion de ces cellules résistantes présente un phénotype d’adhérence accrue dépendant de l’Imatinib (environ 3%). Suite à l’enrichissement de cette population cellulaire (IM-R Adh), nous avons identifié le récepteur αVβ3 comme le seul médiateur de cette adhérence. L’acquisition de ces nouvelles propriétés d’adhérence confère aux cellules IM-R Adh, la capacité de résister à une thérapie ciblant BCR-ABL par un mécanisme appelé CAM-DR (cell adhesion mediated-drug resistance). D’autre part, ce phénotype nouvellement acquis concourt à augmenter, in vitre et in vivo, le potentiel invasif des cellules IM-R Adh. Dans un second temps, nous avons cherché à identifier de nouvelles stratégies thérapeutiques pour circonvenir les résistances à l’Imatinib. Dans le contexte, nous avons été amenés à explorer les mécanismes fondamentaux impliquant l’autophagie dans la différenciation et la mort cellulaire. Ainsi, nous avons évalué l’effet anti-leucémique du Resveratrol. Ce composé polyphénolique est en effet capable d’induire la mort autophagique (ou mort cellulaire de type II) des cellules K562 IM-S et IM-R, suite à l’activation concomitante de l’AMPK et de la voie JNK / c-Jun / SQSTM1. Contrairement au Resveratrol, l’Imatinib n’induit pas de mort de type autophagique mais entraîne une perméabilisation de la membrane des lysosomes qui s’accompagne d’un relargage massif des cathepsines dans le cytoplasme. La cathepsine Bn relocalisée dans le cytoplasme, peut alors cliver BCR-ABL, dans la partie ABL, et contribue ainsi à amplifier l’apoptose induite par l’Imatinib. En accord avec ces données, l’utilisation de Leu-Leu-OMe comme agent déstabilisant la membrane des lysosomes, conduit au clivage de BCR-ABL et à la mort par apoptose des cellules K562 sensibles et résistantes à l’Imatinib. Enfin, nous avons également identifié le PMA comme autre inducteur d’autophagie dans les cellules K562. Cet esther de phorbol, qui a précédemment été décrit au laboratoire pour stimuler la différenciation mégacaryocytaire des cellules K562, nous a permis d’étudier le rôle potentiel de l’autophagie au cours de ce processus de différenciation. Dans ce modèle, nous avons montré que l’inhibition de l’autophagie dépendante de la voie Beclin 1 bloque la différenciation mégacaryocytaire induite par le PMA. L’ensemble de ces résultats souligne donc l’importance de l’autophagie dans les processus physiologiques fondamentaux, notamment la différenciation, ou encore comme cible thérapeutique potentielle dans le traitement de certaines hémopathies malignes.
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Koniakowski, Isabella. "Debugging in a World Full of Bugs : Designing an educational game to teach debugging and error detection with the help of a teachable agent." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-171770.
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This study used the Magical Garden software and earlier research into computational thinking as a point of departure to explore what metaphors could be used and how a teachable agent could be utilised to introduce debugging and error detection to preschool children between four and six years old. A research through design methodology allowed the researcher to iteratively work divergently and convergently through sketching, creating a Pugh matrix, conducting six formative interviews, and finally creating two hybrid-concepts as paths to teaching debugging in the form of concepts. Many metaphors discovered in the design process and in preschool teachers' daily practices were judged possible for teaching debugging and error detection. The analysis of these resulted in four recommendations for choosing a suitable metaphor when teaching debugging: it should have clear rights and wrongs, it should allow for variation, it should have an easily understandable sequentiality to it, and it should be appropriate for the age-group. Furthermore, six recommendations were formulated for utilising a teachable agent: have explicitly stated learning goals, review them and explore new ones as you go, have a diverse design space exploration, make the learning objective task complex, not the game in general, reflect on if using a TA is the best solution, make use of the correct terminology, and keep the graphical elements simple. These recommendations, together with the hybrid-concepts created, provide researchers and teachers with knowledge of how to choose appropriate metaphors and utilise teachable agents when aiming to teach debugging and error detection to children between four and six years old.
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Nguyen, Viet-Dung. "Contribution aux décompositions rapides des matrices et tenseurs." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2085/document.
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De nos jours, les grandes masses de données se retrouvent dans de nombreux domaines relatifs aux applications multimédia, sociologiques, biomédicales, radio astronomiques, etc. On parle alors du phénomène ‘Big Data’ qui nécessite le développement d’outils appropriés pour la manipulation et l’analyse appropriée de telles masses de données. Ce travail de thèse est dédié au développement de méthodes efficaces pour la décomposition rapide et adaptative de tenseurs ou matrices de grandes tailles et ce pour l’analyse de données multidimensionnelles. Nous proposons en premier une méthode d’estimation de sous espaces qui s’appuie sur la technique dite ‘divide and conquer’ permettant une estimation distribuée ou parallèle des sous-espaces désirés. Après avoir démontré l’efficacité numérique de cette solution, nous introduisons différentes variantes de celle-ci pour la poursuite adaptative ou bloc des sous espaces principaux ou mineurs ainsi que des vecteurs propres de la matrice de covariance des données. Une application à la suppression d’interférences radiofréquences en radioastronomie a été traitée. La seconde partie du travail a été consacrée aux décompositions rapides de type PARAFAC ou Tucker de tenseurs multidimensionnels. Nous commençons par généraliser l’approche ‘divide and conquer’ précédente au contexte tensoriel et ce en vue de la décomposition PARAFAC parallélisable des tenseurs. Ensuite nous adaptons une technique d’optimisation de type ‘all-at-once’ pour la décomposition robuste (à la méconnaissance des ordres) de tenseurs parcimonieux et non négatifs. Finalement, nous considérons le cas de flux de données continu et proposons deux algorithmes adaptatifs pour la décomposition rapide (à complexité linéaire) de tenseurs en dimension 3. Malgré leurs faibles complexités, ces algorithmes ont des performances similaires (voire parfois supérieures) à celles des méthodes existantes de la littérature. Au final, ce travail aboutit à un ensemble d’outils algorithmiques et algébriques efficaces pour la manipulation et l’analyse de données multidimensionnelles de grandes taillesLarge volumes of data are being generated at any given time, especially from transactional databases, multimedia content, social media, and applications of sensor networks. When the size of datasets is beyond the ability of typical database software tools to capture, store, manage, and analyze, we face the phenomenon of big data for which new and smarter data analytic tools are required. Big data provides opportunities for new form of data analytics, resulting in substantial productivity. In this thesis, we will explore fast matrix and tensor decompositions as computational tools to process and analyze multidimensional massive-data. We first aim to study fast subspace estimation, a specific technique used in matrix decomposition. Traditional subspace estimation yields high performance but suffers from processing large-scale data. We thus propose distributed/parallel subspace estimation following a divide-and-conquer approach in both batch and adaptive settings. Based on this technique, we further consider its important variants such as principal component analysis, minor and principal subspace tracking and principal eigenvector tracking. We demonstrate the potential of our proposed algorithms by solving the challenging radio frequency interference (RFI) mitigation problem in radio astronomy. In the second part, we concentrate on fast tensor decomposition, a natural extension of the matrix one. We generalize the results for the matrix case to make PARAFAC tensor decomposition parallelizable in batch setting. Then we adapt all-at-once optimization approach to consider sparse non-negative PARAFAC and Tucker decomposition with unknown tensor rank. Finally, we propose two PARAFAC decomposition algorithms for a classof third-order tensors that have one dimension growing linearly with time. The proposed algorithms have linear complexity, good convergence rate and good estimation accuracy. The results in a standard setting show that the performance of our proposed algorithms is comparable or even superior to the state-of-the-art algorithms. We also introduce an adaptive nonnegative PARAFAC problem and refine the solution of adaptive PARAFAC to tackle it. The main contributions of this thesis, as new tools to allow fast handling large-scale multidimensional data, thus bring a step forward real-time applications
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Backman, Emil, and David Petersson. "Evaluation of methods for quantifying returns within the premium pension." Thesis, KTH, Matematisk statistik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-288499.
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Pensionsmyndigheten's (the Swedish Pensions Agency) current calculation of the internal rate of return for 7.7 million premium pension savers is both time and resource consuming. This rate of return mirrors the overall performance of the funded part of the pension system and is analyzed internally, but also reported to the public monthly and yearly based on differently sized data samples. This thesis aims to investigate the possibility of utilizing other approaches in order to improve the performance of these calculations. Further, the study aims to verify the results stemming from said calculations and investigate their robustness. In order to investigate competitive matrix methods, a sample of approaches are compared to the more classical numerical methods. The approaches are compared in different scenarios aimed to mirror real practice. The robustness of the results are then analyzed by a stochastic modeling approach, where a small error term is introduced aimed to mimic possible errors which could arise in data management. It is concluded that a combination of Halley's method and the Jacobi-Davidson algorithm is the most robust and high performing method. The proposed method combines the speed and robustness from numerical and matrix methods, respectively. The result show a performance improvement of 550% in time, while maintaining the accuracy of the current server computations. The analysis of error propagation suggests the output error to be less than 0.12 percentage points in 99 percent of the cases, considering an introduced error term of large proportions. In this extreme case, the modeled expected number of individuals with an error exceeding 1 percentage point is estimated to be 212 out of the whole population.Pensionsmyndighetens nuvarande beräkning av internräntan för 7,7 miljoner pensionssparare är både tid- och resurskrävande. Denna avkastning ger en översikt av hur väl den fonderade delen av pensionssystemet fungerar. Detta analyseras internt men rapporteras även till allmänheten varje månad samt årligen baserat på olika urval av data. Denna uppsats avser att undersöka möjligheten att använda andra tillvägagångssätt för att förbättra prestanda för denna typ av beräkningar. Vidare syftar studien till att verifiera resultaten som härrör från dessa beräkningar och undersöka deras stabilitet. För att undersöka om det finns konkurrerande matrismetoder jämförs ett urval av tillvägagångssätt med de mer klassiska numeriska metoderna. Metoderna jämförs i flera olika scenarier som syftar till att spegla verklig praxis. Stabiliteten i resultaten analyseras med en stokastisk modellering där en felterm införs för att efterlikna möjliga fel som kan uppstå i datahantering. Man drar slutsatsen att en kombination av Halleys metod och Jacobi-Davidson-algoritmen är den mest robusta och högpresterande metoden. Den föreslagna metoden kombinerar hastigheten från numeriska metoder och tillförlitlighet från matrismetoder. Resultatet visar en prestandaförbättring på 550 % i tid, samtidigt som samma noggrannhet som ses i de befintliga serverberäkningarna bibehålls. Analysen av felutbredning föreslår att felet i 99 procent av fallen är mindre än 0,12 procentenheter i det fall där införd felterm har stora proportioner. I detta extrema fall uppskattas det förväntade antalet individer med ett fel som överstiger 1 procentenhet vara 212 av hela befolkningen.
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Graesslin, Olivier. "Etude de l'expression des matrix-métalloprotéases (MMP-2, -7 et -9), des inhibiteurs tissulaires des métalloprotéases (TIMP-1 et -2), des facteurs apoptotiques (P53 et Bcl-2) et des récepteurs hormonaux (RE et RP) dans les cancers et les hyperplasies de l'endomètre par comparaison à l'endomètre sain. Etude de la ploïdie et recherche des anomalies cytogénétiques par FISH. Evaluation de l'implication de ces facteurs dans le processus de carcinogenèse endométriale et de leur intérêt pronostic." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2008. http://tel.archives-ouvertes.fr/tel-00811965.
Full textAbstract:
Le cancer de l'endomètre est le cancer gynécologique le plus fréquemment diagnostiqué chez les femmes en Europe, aux USA et au Japon. Les mécanismes de carcinogenèse endométriale sont encore mal appréhendés et les facteurs histopronostiques classiques ne permettent pas toujours de prédire le risque évolutif. Dans ce travail, l'étude de l'expression des métalloprotéases (MMP-2,-7 et -9) et des inhibiteurs tissulaires des métalloprotéases (TIMP-1 et -2) suggère l'implication de ce système enzymatique dans le processus de carcinogenèse endométriale avec un profil d'expression différent dans l'endomètre normal, l'hyperplasie et le cancer de l'endomètre. Nous avons par ailleurs pu montrer que l'analyse de l'expression de MMP-2 (gélatinase A) et de TIMP-2 permettait de définir un sous-groupe de cancer de l'endomètre qui était particulièrement à risque d'extension locale et à distance. Nos résultats ont également permis de confirmer le rôle prépondérant de la perte d'hétérozygotie (LOH) de TP53 dans la genèse des cancers de l'endomètre de type II et la survenue plus tardive de cet évènement dans les cancers de l'endomètre de type I (hormonodépendants). En terme de pronostic, l'analyse du gène TP53 par FISH (hybridation par fluorescence in situ) n'est pas supérieure à celle obtenue par IHC (immunohistochimie). Enfin, l'étude des corrélations histopronostiques réalisée dans ce travail suggère que l'évaluation conjointe de la ploïdie, de MMP-2 et TIMP-2, de p53, du Ki67 et des récepteurs hormonaux (E et P) sur les prélèvements tissulaires pourrait mieux définir une population à haut risque évolutif pouvant bénéficier de thérapeutique ciblée.
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Graesslin, Olivier. "Etude de l'expression des matrix-métalloprotéases (MMP-2, -7 et -9), des inhibiteurs tissulaires des métalloprotéases (TIMP-1 et -2), des facteurs apoptotiques (P53 et Bcl-2) et des recepteurs hormonaux (RE et RP) dans les cancers et les hyperplasies de l'endomètre par comparaison à l'endomètre sain : étude de la ploïdie et recherche des anomalies cytogénétiques par FISH : évaluation de l'implication de ces facteurs dans le processus de carcinogenèse endométriale et de leur intérêt pronostic." Paris 6, 2008. https://tel.archives-ouvertes.fr/tel-00811965.
Full textAbstract:
Le cancer de l'endomètre est le cancer gynécologique le plus fréquemment diagnostiqué chez les femmes en Europe, aux USA et au Japon. Les mécanismes de carcinogenèse endométriale sont encore mal appréhendés et les facteurs histopronostiques classiques ne permettent pas toujours de prédire le risque évolutif. Dans ce travail, l’étude de l’expression des métalloprotéases (MMP-2,-7 et -9) et des inhibiteurs tissulaires des métalloprotéases (TIMP-1 et -2) suggère l’implication de ce système enzymatique dans le processus de carcinogenèse endométriale avec un profil d’expression différent dans l’endomètre normal, l’hyperplasie et le cancer de l’endomètre. Nous avons par ailleurs pu montrer que l’analyse de l’expression de MMP-2 (gélatinase A) et de TIMP-2 permettait de définir un sous-groupe de cancer de l’endomètre qui était particulièrement à risque d’extension locale et à distance. Nos résultats ont également permis de confirmer le rôle prépondérant de la perte d’hétérozygotie (LOH) de TP53 dans la genèse des cancers de l’endomètre de type II et la survenue plus tardive de cet évènement dans les cancers de l’endomètre de type I (hormonodépendants). En terme de pronostic, l’analyse du gène TP53 par FISH (hybridation par fluorescence in situ) n’est pas supérieure à celle obtenue par IHC (immunohistochimie). Enfin, l’étude des corrélations histopronostiques réalisée dans ce travail suggère que l’évaluation conjointe de la ploïdie, de MMP-2 et TIMP-2, de p53, du Ki67 et des récepteurs hormonaux (E et P) sur les prélèvements tissulaires pourrait mieux définir une population à haut risque évolutif pouvant bénéficier de thérapeutique ciblée.
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Li, Wan-hua, and 李婉華. "Improvement of the BCG Matrix Model." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/37966847421035459743.
Full textAbstract:
碩士正修科技大學
工業工程與管理研究所
97
The present BCG belong to static model, it can only show the present state of SBU. Therefore, this study will be used GE model of the future direction of the arrow pattern added to the analysis of BCG, and add the possibility of position changes, it will clear to show that the present location of the various institutions, the future development of the forecast position and future direction. In addition, the traditional model does not consider the BCG matrix between SBU substitution, complementary relationship, the inter-SBU In this study, alternative, complementary relationship, the give a few cases, BCG matrix model to analyze the application of its strategy.
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Huang, Shin-I., and 黃心怡. "Share Repurchase Announcement Effect-BCG Matrix Perspective." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/32dwf3.
Full textAbstract:
碩士國立臺中科技大學
企業管理系碩士班
104
To explore the announcement effect of stock repurchasing by listed and over-the-counter (OTC) firms, we divide them into Star businesses, Cash Cow businesses, Dog businesses, and Question Mark businesses according to market share rate and revenue growth rate in a Boston Consulting Group (BCG) matrix. The study period was from August 2000 to December 2014. We conduct an event study to investigate the short-term and long-term responses of stock prices after firms repurchase their stocks. The results show that stock prices are underestimated before stock repurchasing is announced; however, the announcement of stock repurchasing elicits a positive response. Announcement strength varies among various businesses. Regarding short-term announced performance, Dog businesses with a low market share rate and revenue growth rate present the highest abnormal returns after a stock repurchasing announcement, followed by Cash Cow businesses, Star businesses, and then Question Mark businesses. Regarding long-term announced performance, Cash Cow businesses with a high market share rate and revenue growth rate present the highest abnormal returns after a stock repurchasing announcement, followed by Dog businesses, Star businesses, and then Question Mark businesses.
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LO, TSUNG-YUAN, and 駱重遠. "A Case Study of BCG Matrix Used in Corporate Restructuring." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/53106587909371528001.
Full textAbstract:
碩士國立臺灣科技大學
財務金融研究所
101
This research is based on a case company as a discussion object , researched the tightening corporate restructuring plan decision faced by the company's diversification discount after the start. Through BCG matrix analysis, product life cycle, organizational relationships, and through the collection of domestic and foreign literature and related information on company background, reasons of corporate restructuring, corporate restructuring, and subsequent effective to investigate the case company BCG matrix applications in the enterprise restructuring strategy is correct. And case company executives depth interviews to understand the industry characteristics and trends, assessments of its decision-making process, the final analysis of the overall synergy. This study proposes the following conclusions: 1. Enterprises using the BCG matrix to determine the industry status for each product individually be viewed, and then based on the analysis of results and consider their own industry characteristics and customers' business strategy to determine the corporate restructuring decisions. 2. BCG matrix analysis implied the concept of the product life cycle, the product life cycle corresponding to the type of management of the different organizations is a key factor for enterprises in restructuring decisions must consider, therefore BCG matrix analysis of a reference value. 3. BCG matrix has its limitations on the model, for the small market share of niche products, there is the blind spot analysis. In addition, if no strong BCG matrix cash cow business backing as a source of funds, can not be long-term support diversification strategy.
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LIN, YA-HUI, and 林雅惠. "The Difference Analysis for Fund Family’sMutual Funds Grouped by BCG Matrix." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/55nh4c.
Full textAbstract:
碩士大葉大學
管理學院碩士在職專班
106
In this study, domestic equity funds are divided into four groups by BCG matrix, and their performance, risk, expense, and turnover ratio are compared. Furthermore, the differences between the investors' subscription and redemption for these four groups of funds are compared. The empirical results indicate that the fund performance of the star funds and question funds is significantly better than that of the cash cow funds and the dog funds. The risk of the star funds is significantly greater than that of the other three groups Fund expenses indeed have economies of scale. Star funds have the lowest expense ratio, while dog funds have the highest expense ratio, and the difference of expense between question funds and cash cow funds is not significant. The distribution of turnover ratio is similar to the expense because the higher turnover raises the higher transaction cost. The star funds have the largest amount of subscriptions, the second is cash cow funds, the third is question funds and the last is dog funds. After controlling other factors that affecting the performance, the fund performance of the star funds and the question funds is also significantly better than that of the cash cow funds and the dog funds. Key Words: Mutual Fund, BCG Matrix, Fund Characteristic