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Journal articles on the topic 'Bcl-2 marker'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Trajkova, Sanja, Svetlana Krstevska-Balkanov, Gordana Petrusevska, et al. "Prognostic impact of immunophenotyping of diffuse large B-cell lymphoma - a single-centre experience." Macedonian Pharmaceutical Bulletin 67, no. 1 (2021): 43–54. http://dx.doi.org/10.33320/10.33320/maced.pharm.bull.2021.67.01.005.

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The concept generated by biological expression profile divided patients with diffuse large B-cell lymphoma (DLBCL) into two subtypes. This concept has been presented in the recent editions of WHO classification and became a prognostic tool. Aim of the study was introduction of new three-marker model for immunohistochemical and prognostic subclasification of patients with DLBCL. Our retrospective study enrolled 200 adult patients with DLBCL diagnosed and treated in the period between January 2013 to January 2021. They were all treated with chemoimmunotherapy with R+/-CHOP regimen and the median

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Pophali, Priyanka, Lisa M. Marinelli, Rhett P. Ketterling, et al. "High Level MYC Amplification in Aggressive B-Cell Lymphomas: Is It a Marker of Aggressive Disease?" Blood 132, Supplement 1 (2018): 1693. http://dx.doi.org/10.1182/blood-2018-99-115484.

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Abstract MYC amplification (amp) is a marker of poor prognosis in many non-hematologic malignancies. While MYC translocations in B cell lymphoma (BCL) have been extensively studied, little is known about the significance of MYC amp. Recent studies describe increased MYC copy numbers (3-10 copies/cell) to be associated with more aggressive BCL. The WHO 2017 does not include MYC amp in the definition of high-grade BCL (HGBCL) with MYC and BCL2 and/or BCL6 rearrangement ("double-hit lymphoma", DHL). However, it also states that high-level MYC amp occurring together with a MYC rearrangement, and c

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3

Nitika Kumari, Natarajan Suresh, and Josephine A. "Significance of Bcl-2 expression in breast cancer." Biomedicine 42, no. 4 (2022): 775–77. http://dx.doi.org/10.51248/.v42i4.1578.

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Introduction and Aim: The most prevalent and lethal form of cancer in women, breast carcinoma is thought to account for 2,088, 849 (11.6%) of all new cases each year. Protooncogene Bcl-2 is primarily present in the perinuclear membrane. Examining the significance of Bcl-2 expression as a predictive factor in breast cancer is the goal of the current investigation. Materials and Methods: From December 2019 to January 2021, a tertiary care hospital in Chennai conducted this investigation on 42 cases of mastectomy specimens. Using tools from Path Insitu, Bcl-2 marker immunohistochemistry was carri

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4

Tukaram Patil, Shilpa, Clement Wilfred Devadass, and Prasanna Shetty Badila. "Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma." Iranian Journal of Pathology 14, no. 4 (2019): 317–21. http://dx.doi.org/10.30699/ijp.2019.102982.2028.

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Introduction: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, but results have been contradictory. Objectives: To evaluate the histopathological features of colorectal carcinoma, analyze the immunohistochemical expression of Bcl-2, and to find out statistical association of Bcl-2 expression with certain prognostic factors histopathologic type, grade and stage. Material an

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5

Arana, Rosa M., Pedro Sobrevilla-Calvo, Silvia Rivas-Vera, et al. "High Incidence of Bcl-2/IgH Rearrangement in Mexican Patients With Follicular Lymphoma and Its Relevance as a Marker for Minimal Residual Disease." Blood 106, no. 11 (2005): 4493. http://dx.doi.org/10.1182/blood.v106.11.4493.4493.

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Abstract Follicular lymphoma is frequently associated with the chromosomal rearrangement t(14;18)(q32;q21), which joints one of the JH segments of the heavy chains of immunoglobulins (IgH) gene in 14q32 with the Bcl-2 gene in 18q2, originating a chimeric protein. The frequency of this marker is unknown in the Mexican population. OBJECTIVE: To determine the incidence of the Bcl2-IgH rearrangement in Mexican patients with follicular lymphoma and its frequency as a marker of minimal residual disease after therapy. PATIENTS AND METHODS: 200 patients (102 male and 98 female) were evaluated; the ana

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6

Lee, K., B. Kim, S. Lee, et al. "Prognostic significance of bcl-2 expression in stage III breast cancer patients who received doxorubicin and cyclophosphamide followed by paclitaxel as adjuvant chemotherapy." Journal of Clinical Oncology 24, no. 18_suppl (2006): 670. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.670.

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670 Background: Bcl-2 is an anti-apoptotic marker and regulated by hormonal receptor pathways in breast cancer. We performed this study to assess the prognostic significance of ER, PR, p53, c-erbB2, bcl-2, Ki-67, and EGFR as a marker for relapse in breast cancer patients who received same adjuvant therapy in a single institution. Methods: A cohort of 154 curatively resected breast cancer patients who had 4 lymph nodes or more and received doxorubicin and cyclophosphamide followed by paclitaxel (AC/T) as adjuvant chemotherapy was analyzed for clinicopathologic characteristics including disease-

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7

Ozretic, Petar, Ilija Alvir, Bozena Sarcevic, et al. "Apoptosis regulator Bcl-2 is an independent prognostic marker for worse overall survival in triple-negative breast cancer patients." International Journal of Biological Markers 33, no. 1 (2017): 109–15. http://dx.doi.org/10.5301/ijbm.5000291.

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Background: The objective of this study was to examine the prognostic significance of carbonic anhydrase IX (CAIX), an endogenous marker for tumor hypoxia; the cellular tumor antigen p53; and the apoptosis regulator Bcl-2, in triple-negative breast cancer (TNBC) patients. Methods: Immunohistochemically determined expression of CAIX, p53, Bcl-2 and proliferation factor Ki-67, analyzed in 64 paraffin-embedded TNBC tissue samples, was used to assess their relation to clinicopathological variables and prognostic implications for overall survival (OS). Results: Bcl-2 expression was negatively corre

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8

Biesterfeld, S., R. Doetkotte, and C. Rudlowski. "bcl-2 — an independent prognostic marker in breast cancer." Pathology - Research and Practice 200, no. 4 (2004): 306. http://dx.doi.org/10.1016/s0344-0338(04)80596-x.

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9

AL- Mudallal, Subh S., and Huda N. Jasim. "Evaluation of Bcl 2 and Ki 67 expression in Chronic Lymphocytic Leukemia ." Journal of the Faculty of Medicine Baghdad 54, no. 4 (2013): 335–39. http://dx.doi.org/10.32007/jfacmedbagdad.544698.

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Background :Chronic lymphocytic leukemia (CLL) is a low-grade B-lineage lymphoid malignancy. Both Ki-67 which is a large nuclear protein associated with cell proliferation and Bcl-2 which is an anti-apoptotic protein which is associated with dysregulation of the intrinsic apoptotic pathway , were thoroughly investigated in many cancer patients particularly in hemopoietic malignancies . Patients, materials and methods: This retrospective study was conducted from November 2009 to May 2010 , on fifty formaline fixed paraffin embedded blocks of CLL cases retrieved from Medical City Teaching

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El-Agawy, Mosaab Salah El-din, Alaa Mohamed Mohamed Badawy, Mohammed R. Rabei, et al. "Methotrexate-Induced Alteration of Renal Aquaporins 1 and 2, Oxidative Stress and Tubular Apoptosis Can Be Attenuated by Omega-3 Fatty Acids Supplementation." International Journal of Molecular Sciences 23, no. 21 (2022): 12794. http://dx.doi.org/10.3390/ijms232112794.

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Methotrexate (MTX) is a potent anti-cancer drug, commonly associated with nephrotoxicity via the induction of oxidative stress and apoptosis with alteration of renal water channel proteins, namely aquaporins (AQPs). Omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) have shown cytoprotective effects through their anti-oxidant and antiapoptotic activities. The present study aims for the first time to explore the role of LC-PUFA against MTX-induced nephrotoxicity. Rats were divided into the following groups: saline control, LC-PUFA control, MTX, MTX + LC-PUFA (150 mg/kg), or MTX + LC-PUFA

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Bento, Leyre, Gabriela Rodriguez Macias, Pascual Balsalobre, et al. "Role of Bcl-2 Immunohistochemical Expression As An Independent Biological Prognostic Marker At Diagnosis of Classical Hodgkin's Lymphoma." Blood 118, no. 21 (2011): 4859. http://dx.doi.org/10.1182/blood.v118.21.4859.4859.

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Abstract Abstract 4859 BACKGROUND: Most patients with classical Hodgkin's Lymphoma (CHL) are cured with primary treatment. However, a proportion of them fail to first line treatment needing to be rescued with subsequent lines of chemotherapy and/or autologous or allogeneic stem cell transplantation (auto-SCT and allo-SCT, respectively). The identification of clinical and biological characteristics of these patients at diagnosis is still a challenge and most prognostic systems fail to identify a proportion of patients with worse prognosis. In this context, different groups are currently analyzi

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Hsieh, Ricardo, and Silvia Vanessa Lourenço. "Does BCL-2 Play Role in the Pathogenesis of Primary Oral Mucosal Melanoma?" Journal of Medical Research and Surgery 1, no. 2 (2020): 1–3. http://dx.doi.org/10.52916/jmrs204007.

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Primary Oral Mucosal Melanoma represents 0.2 to 8% of all melanomas and 0.5% of all oral malignant neoplasia. The etiology still unknown, however, it has been suggested that head and neck mucosal melanomas change their genetic and metabolic pathways through intracellular cascades, which are associated with its etiopathogenesis mechanisms. The BCL2 protein is an integral part of the cell membrane, and it is also found in the cell nucleus, mitochondria, and endoplasmic reticulum. It is overexpressed in several malignant neoplasms, including cutaneouse ocular melanomas. Among all evaluated cases,

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Cherdantseva, Tat’yana M., I. P. Bobrov, A. F. Lazarev, V. V. Klimachev, and A. M. Avdalyan. "Expression and prognostic significance of bcl-2 apoptosis inhibitor in renal cell carcinoma." Russian Journal of Oncology 20, no. 3 (2015): 27–31. http://dx.doi.org/10.17816/onco40168.

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This articlepresents the study of prognostic significance of bcl-2 apoptosis inhibitor expression in renal cell carcinoma. Operation samples of 59 patients with renal cell carcinoma were studied. Average age of patients was 56,6 ± 1,3 years. 31 (52,5 %) were men , 28 (47,5 %)-women . Correlations were found between bcl-2, clinical cancer stage (r = 0,31; р = 0,02), size of tumor node (r = 0,29; р = 0,02), regional and distant metastasis ( r = 0,35; р = 0,005) and histologic tumor type (r = 0,41; р = 0,002). No correlation was found with patients ’ sex (r = 0,16; р = 0,22), age (r = 0,17; р = 0

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14

Nueckel, Holger, Ulrich H. Frey, Ludger Sellmann, Jan Duerig, Ulrich Duehrsen, and Winfried Siffert. "Association of a Novel Regulatory Polymorphism (-938C>A) in the BCL2 Gene with Disease Progression in Chronic Lymphocytic Leukemia." Blood 106, no. 11 (2005): 2105. http://dx.doi.org/10.1182/blood.v106.11.2105.2105.

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Abstract Bcl-2 plays a key role in the regulation of apoptosis. We investigated the role of a novel regulatory single nucleotide polymorphism in the BCL2 gene (−938C>A) in B-CLL. Bcl-2 protein expression in B-cells from CLL patients carrying the −938 AA genotype was significantly increased compared to AC and CC genotypes. Moreover, the −938C- and A-alleles differed with regard to the binding of nuclear proteins. Genotype distributions between 123 CLL patients (42 AA, 55 AC, 26 CC) and in 109 age-matched healthy controls (38 AA, 55 AC, 16 CC) were not significantly different suggesting that

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15

Perera, Tarique D., Dunyue Lu, Lakshmi Thirumangalakudi, et al. "Correlations between Hippocampal Neurogenesis and Metabolic Indices in Adult Nonhuman Primates." Neural Plasticity 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/875307.

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Increased neurogenesis in feeding centers of the murine hypothalamus is associated with weight loss in diet-induced obese rodents (Kokoeva et al., 2005 and Matrisciano et al., 2010), but this relationship has not been examined in other species. Postmortem hippocampal neurogenesis rates and premortem metabolic parameters were statistically analyzed in 8 chow-fed colony-reared adult bonnet macaques. Dentate gyrus neurogenesis, reflected by the immature neuronal marker, doublecortin (DCX), and expression of the antiapoptotic gene factor, B-cell lymphoma 2 (BCL-2), but not the precursor proliferat

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Khalissa, Deffar, Khenchouche Abdelhalim, Xing Xie, Ying Li, Ouhida Soraya, and Mahnane Abbes. "Immunohistochemical Expression of p53 and Bcl-2 in Algerian Cervical Carcinoma." Biomedical and Pharmacology Journal 11, no. 1 (2018): 67–75. http://dx.doi.org/10.13005/bpj/1348.

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The Objective of the present study is to evaluate the expression levels of Bcl-2 and p53 proteins in squamous cell carcinoma and adenocarcinoma of the uterine cervix, and try to explain their role as prognostic markers for this cancer. The cohort comprised 90 cases of the cervix lesions. The samples were assessed by immunohistochemistry for the expression of Bcl-2 and p53 proteins. The results showed that the Bcl-2 expression was either absent, low or moderate respectively in 38.96%; 50.65% and 10.39% of SCC cases. However, it was absent or expressed in 76.92% and 23.08% of adenocarcinoma case

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17

Jamieson, Catriona, Sidd Jaiswal, David Traver, Jason Gotlib, Mark Chao, and Irving L. Weissman. "Increased Expression of CD47 Is a Constant Marker in Mouse and Human Myeloid Leukemias." Blood 106, no. 11 (2005): 3260. http://dx.doi.org/10.1182/blood.v106.11.3260.3260.

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Abstract CD47, also known as integrin associated protein, is a ubiquitously expressed cell surface glycoprotein that interacts with a number of integrins, modulating leukocyte adhesion, migration, cell motility and platelet activation. CD47 is also the ligand for the macrophage inhibitory receptor signal regulatory protein α (SIRP α) and thus, impairs macrophage-mediated phagocytosis. Recent reports suggest that increased CD47 expression may play a role in the pathogenesis of lymphoproliferative disorders such as CLL (Mateo et al, Nat Med.1999; 5:1277) and multiple myeloma, and that a bivalent

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18

Rajvik, Kruti, Pooja Parmar, and Beena Bhrambahtt. "Evaluation of Hexokinase 2 and Serum LDH in B-cell Non-Hodgkin’s Lymphoma Patients." International Journal of Research and Review 10, no. 1 (2023): 1–10. http://dx.doi.org/10.52403/ijrr.20230101.

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Background and Objective: Tumor cells produce energy by glycolysis and Lactate Dehydrogenase and Hexokinase are the key part of glycolysis, The present study aimed to evaluate the expression of Hexokinase 2 and serum LDH in B-cell Non-Hodgkin’s Lymphoma patients Method: A total of 84 B-cell Non-Hodgkin’s Lymphoma Patients were enrolled in the study. HK-2 Marker was studied by Immunohistochemistry and LDH analysis was done by Cobas 6000 analyser method and correlated with Clinico-Pathological Parameters and Diagnostic panel. RESULT:73% of B-cell NHL patients had Abnormal LDH. It was significant

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Safarova, Saodat M. "Morphological characteristics of uterine fibroids among women of reproductive age." Journal of obstetrics and women's diseases 66, no. 1 (2017): 27–31. http://dx.doi.org/10.17816/jowd66127-31.

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The article deals with modern views on etiopathogenesis of uterine fibroids. Increased knowledge of the markers of proliferation and their study will help to predict the course of the disease and thus to develop the optimum tactics of the further treatment of the early stages. Much attention is paid to the study of markers that characterize apoptosis. By immunohistochemistry in tissue fibroids 15 patients studied protein expression Ki-67 and Bcl-2. Analyzed values of the correlation expression of the proteins according to the clinical and morphological features of the tumor. It showed a reduct

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Chen, Fen-fen, Jing-jou Yan, Ying-tai Jin, and Ih-jen Su. "Detection of bcl-2 and p53 in thymoma: Expression of bcl-2 as a reliable marker of tumor aggressiveness." Human Pathology 27, no. 10 (1996): 1089–92. http://dx.doi.org/10.1016/s0046-8177(96)90289-0.

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Kaban, Kübra, Clemens Hinterleitner, Yanjun Zhou, et al. "Therapeutic Silencing of BCL-2 Using NK Cell-Derived Exosomes as a Novel Therapeutic Approach in Breast Cancer." Cancers 13, no. 10 (2021): 2397. http://dx.doi.org/10.3390/cancers13102397.

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Overexpression of the anti-apoptotic protein BCL-2 is frequently observed in multiple malignancies, including about 85% of patients with estrogen receptor positive (ER+) breast cancer. Besides being studied as a prognostic marker, BCL-2 is investigated as a therapeutic target in ER+ breast cancer. Here, we introduce a new exosome-based strategy to target BCL-2 using genetically modified natural killer (NK) cells. The NK cell line NK92MI was lentivirally transduced to express and load BCL-2 siRNAs (siBCL-2) into exosomes (NKExos) and then evaluated for its potential to treat ER+ breast cancer.

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Sulaimanova, Rimma T., and Andrey N. Kvochko. "Molecular biological marker BCL-2: testis analysis in prenatal injection of estrogen to white laboratory mice." RUDN Journal of Agronomy and Animal Industries 18, no. 2 (2023): 273–81. http://dx.doi.org/10.22363/2312-797x-2023-18-2-273-281.

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Immunohistochemical study is one of the modern methods of disease diagnostics used in practical veterinary practice, as well as in scientific developments in differential diagnostics of animal diseases of tumour and non-tumour nature. Prenatal influence of estrogens results in reproductive system disorders in an adult organism which is accompanied by parallel growth of steroid dependent cancers of the offspring: testicles and ovaries. The aim of the study was to perform immunohistochemical analysis of Bcl-2 marker during prenatal exposure to different doses of the synthetic estrogen analogue S

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Fortner, Colin, Maren Wichert, Alexandra Niedermayer, Klaus-Michael Debatin, Lüder Hinrich Meyer, and Felix Seyfried. "Identification of vulnerabilities for targeting BCL-2 family members in T-Cell Acute Lymphoblastic Leukemia." Blood 142, Supplement 1 (2023): 1608. http://dx.doi.org/10.1182/blood-2023-177613.

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T-Cell acute lymphoblastic leukemia (T-ALL) is a disease caused by the malignant transformation of T-cell lineage progenitors. With the use of intensive chemotherapies survival rates have improved, but outcomes particularly of relapsed patients remain poor. In addition, currently used intensive chemotherapies are associated with high rates of treatment-related morbidity and mortality, emphasizing the need to develop new and improved therapies. The intrinsic apoptosis pathway, one of the key pathways controlling cell death, is dysregulated in many cancers and contributes to leukemogenesis and t

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Bajic, Zorislava, Tanja Sobot, Ljiljana Amidzic, et al. "Liraglutide Protects Cardiomyocytes against Isoprenaline-Induced Apoptosis in Experimental Takotsubo Syndrome." Biomedicines 12, no. 6 (2024): 1207. http://dx.doi.org/10.3390/biomedicines12061207.

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Takotsubo syndrome (TTS) is a stress-induced cardiomyopathy, characterized by an increased concentration of catecholamines, free radicals, and inflammatory cytokines, endothelial dysfunction, and increased apoptotic activity. High doses of isoprenaline are used in animal models to induce Takotsubo (TT)-like myocardial injury. The aim of the study was to investigate the antiapoptotic effects of liraglutide in experimental TTS and its role in the NF-κB pathway. Wistar rats were pretreated with liraglutide for 10 days, and on days 9 and 10, TT-like myocardial injury was induced with isoprenaline.

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Gagua, Irina Rezo. "Expression and the prognostic relevance of p53, Bcl-2, Bax, and Ki-67 in uterine leiomyosarcoma." Journal of Clinical Oncology 30, no. 15_suppl (2012): e15506-e15506. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e15506.

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e15506 Background: Uterine leiomyosarcomas (LMS) are rare, aggressive gynecological malignancies of the female reproductive tract. They represent less than 2-5% of all uterine malignancies. Despite the advanced modern treatment modalities, according to our data 5 year overall and disease - free survival of patients with LMS is 48,5± 4,2% and 44.3 ± 4.3 %, respectively. One of the challenging directions in advancing the prognosis and optimization of treatment tactics in LMS is investigating the expression of molecular-biological markers in tumor tissue. So, the aim of our study was to evaluate

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Darenskaia, Anna D., Natal'ia V. Dobrova, and Evgeniia V. Stepanova. "Molecular-biological marker Bcl-2 in colorectal cancer: the characteristics, the role of mechanisms regulating apoptosis, the effect on the prognosis (review of literature)." Journal of Modern Oncology 21, no. 1 (2019): 52–58. http://dx.doi.org/10.26442/18151434.2019.1.190278.

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Background. Many studies concerning molecular-biological markers in colorectal cancer (CRC) were performed over the past decade. Вcl-2 protein (B-cell lymphoma 2) was one of the most studied molecular-biological markers and attracted the attention of different specialties as on studying carcinogenesis and the relationship with prognosis. Aim. To study in details the characteristics of Bcl-2; to study Bcl-2 role in the mechanisms regulating apoptosis; to show update data concerning the prognostic significance of this protein in CRC. Materials and methods. To write this literature review we have

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Zhang, Fei, Jing Wang, Jianjun Chu, et al. "MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through Bcl-2." Cellular Physiology and Biochemistry 37, no. 4 (2015): 1442–53. http://dx.doi.org/10.1159/000438513.

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Background/Aims: There have been many studies on the etiology of osteoarthritis (OA) with regard to the function of inflammatory cytokines, the process of cartilage degradation, the function of miR-146a, hypoxia stimulation and autophagy in OA chondrocytes, but there have been no reports on the relationship between miR-146a and autophagy in cartilage, especially under hypoxia. This study aimed to confirm the relationship of miR-146a and autophagy in cartilage under hypoxia. Methods: Chondrocytes were treated by hypoxia gradients, and the main factors including HIF-1α, HIF-2α, miR-146a and Bcl-

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Nückel, Holger, Ulrich H. Frey, Maja Bau, et al. "Association of a novel regulatory polymorphism (−938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia." Blood 109, no. 1 (2006): 290–97. http://dx.doi.org/10.1182/blood-2006-03-007567.

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Abstract Bcl-2 plays a key role in the regulation of apoptosis. We investigated the role of a novel regulatory single-nucleotide polymorphism (−938C>A) in the inhibitory P2 BCL2 promoter in B-cell chronic lymphocytic leukemia (B-CLL). The −938C allele displayed significantly increased BCL2 promoter activity and binding of nuclear proteins compared with the A allele. Concomitantly, Bcl-2 protein expression in B cells from CLL patients carrying the −938 AA genotype was significantly increased compared with CC genotypes. Genotype distribution between 123 CLL patients (42 AA, 55 AC, 26 CC) and

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Kusuma, Vania Islamey, Reny I’tishom, Ema Qurnianingsih, and Purwo Sri Rejeki. "A Systematical Review of The Effect of Ketogenic Diet on Bcl-2 (B-cell lymphoma-2) Expression as An Apoptosis Marker in Cancer Treatment." Biomolecular and Health Science Journal 4, no. 2 (2021): 130. http://dx.doi.org/10.20473/bhsj.v4i2.30173.

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Introduction: Ketogenic diet seems to be in a great demand nowadays as a lot of people are interested in adopting it into their lifestyle. It is also found that the ketogenic diet shows several beneficial effects including cancer prevention. However, the detail mechanism still remains unknown. Therefore, this review was aimed to find out the effect of ketogenic diet on Bcl-2 (B-cell lymphoma-2) expression in cancer.Methods: We searched published literatures in PubMed through 2011-2020 using specific keywords. The literatures were filtered according to inclusion and exclusion criteria. Animal m

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Zhuk, S. I., O. A. Taran, A. N. Koshmienskaya, and T. V. Lobastova. "The role of immunohistochemistry in the diagnosis of cervical intraepithelial neoplasia of different severity." HEALTH OF WOMAN, no. 7(113) (September 30, 2016): 138–40. http://dx.doi.org/10.15574/hw.2016.113.138.

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The objective: the finding of protein expression of apoptosis regulator BCL-2, Smooth Muscule Actin and the antigen Ki-67 in cervical intraepithelial neoplasia of different severity to optimize the diagnosis and prognosis of the disease. Patients and methods. The study involved 42 women of reproductive age with cervical intraepithelial the neoplasia of the cervix varying degrees applied to the doctor of cervical pathology Zhitomir regional oncologic dispensary. All women (n=42) were divided into groups. The first group included 15 patients (35.7%) with cervical intraepithelial neoplasia with m

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Huang, Jen-Ming, Tsen-Yin Lin, Donald Chang, Shi-Lung Lin, and Shao-Yao Ying. "Truncated Bcl-2, a potential pre-metastatic marker in prostate cancer." Biochemical and Biophysical Research Communications 306, no. 4 (2003): 912–17. http://dx.doi.org/10.1016/s0006-291x(03)01072-6.

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Guimarães, Márcia C. M., Maria Alice G. Gonçalves, Christiane P. Soares, Jussara S. R. Bettini, Roberta A. Duarte, and Edson G. Soares. "Immunohistochemical Expression of p16INK4a and bcl-2 According to HPV Type and to the Progression of Cervical Squamous Intraepithelial Lesions." Journal of Histochemistry & Cytochemistry 53, no. 4 (2005): 509–16. http://dx.doi.org/10.1369/jhc.4a6312.2005.

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Inactivation of the cell cycle inhibitor gene p16MTS1 seems to be involved in human papillomavirus (HPV)-related carcinogenesis because E6 and E7 oncoproteins may impair p16INK4a and, indirectly, bcl-2 functions. In this study, we analyzed the role of immunohistochemical expression of p16INK4a and bcl-2 in HPV-infected cervical biopsies as prognostic markers of the progression of squamous intraepithelial lesion (SIL). Sixty-five cervical biopsies were stratified into two subgroups according to the second biopsy: 27 of them maintained a low-grade (LG)-SIL diagnosis, and 38 progressed from LG-SI

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Berezovskaya, T. I., and I. A. Odintsova. "Dynamics of Cell Death Marker Protein Expression in Post-Traumatic Histogenesis of Skin Connective Tissues." Journal of Anatomy and Histopathology 14, no. 2 (2025): 31–37. https://doi.org/10.18499/2225-7357-2025-14-2-31-37.

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The aim was to use immunohistochemistry to assess the dynamics of p53, casp3, and bcl-2 protein expression in rat skin connective tissue cells during the stages of post-traumatic histogenesis. Material and methods. The experiment was performed on male Wistar rats (n=40) weighing 200–230 g. A deep transverse incisional skin wound was created in the middle third of the thigh using a sharp scalpel. Specimens were obtained at 12 hours, 24 hours, 2, 3, 6, 10, 15, and 25 days following injury, using 5 animals for each time interval. Five intact animals served as controls. Expression of p53, caspase-

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Campos, L., JP Rouault, O. Sabido, et al. "High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy." Blood 81, no. 11 (1993): 3091–96. http://dx.doi.org/10.1182/blood.v81.11.3091.3091.

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Abstract The BCL-2 proto-oncogene encodes a mitochondrial protein that blocks programmed cell death. High amounts of bcl-2 protein are found not only in lymphoid malignancies, but also in normal tissues characterized by apoptotic cell death, including bone marrow. Using a monoclonal antibody to bcl-2 protein, we analyzed 82 samples of newly diagnosed acute myeloid leukemia. The number of bcl-2+ cells in each sample was heterogeneous (range, 0% to 95%), with a mean of 23%. The percentage of bcl-2+ cells was higher in M4 and M5 types, according to French- American-British classification, and in

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Campos, L., JP Rouault, O. Sabido, et al. "High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy." Blood 81, no. 11 (1993): 3091–96. http://dx.doi.org/10.1182/blood.v81.11.3091.bloodjournal81113091.

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The BCL-2 proto-oncogene encodes a mitochondrial protein that blocks programmed cell death. High amounts of bcl-2 protein are found not only in lymphoid malignancies, but also in normal tissues characterized by apoptotic cell death, including bone marrow. Using a monoclonal antibody to bcl-2 protein, we analyzed 82 samples of newly diagnosed acute myeloid leukemia. The number of bcl-2+ cells in each sample was heterogeneous (range, 0% to 95%), with a mean of 23%. The percentage of bcl-2+ cells was higher in M4 and M5 types, according to French- American-British classification, and in cases wit

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Gokalp-Ozkorkmaz, Ebru, Firat Asir, Sureyya Ozdemir Basaran, et al. "Examination of Bcl-2 and Bax Protein Levels for Determining the Apoptotic Changes in Placentas with Gestational Diabetes and Preeclampsia." Proceedings 2, no. 25 (2018): 1548. http://dx.doi.org/10.3390/proceedings2251548.

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Anti-apoptotic Bcl-2 and proapoptotic Bax genes are the most significant genes that are involved in the regulation of apoptosis. Abnormal apoptotic activity in preeclampsia and gestational diabetes is caused by dysregulation of these genes. In this study; we examined Bcl-2 and Bax protein expressions using immunohistochemical techniques in human placental tissue samples from cases of gestational diabetes (n: 20) and preeclampsia (n: 20). It was observed that Bax expression showed positive reaction compared to Bcl-2 expression so; Bax protein was thought to be an effective marker in determining

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Gusti, Yesi, Arni Amir, and Gusti Revilla. "Omega-3 and Vitamin E Supplementation Effect to Rattus Norvegicus Placental Apoptosis Marker: Pre-Eclampsia Model." International Journal of Science and Healthcare Research 6, no. 4 (2021): 261–68. http://dx.doi.org/10.52403/ijshr.20211037.

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Background: Pre-eclampsia has been associated with the increased of placental apoptosis caused by oxidative stress. Omega-3 fatty acids and vitamin E had beneficial function to maintain cell membranes, prevent oxidative stress and inhibit the production of proinflammatory cytokines. The purpose of the study was to determine the effect of omega-3 and vitamin E supplement to BCL-2 and BAX on PE rats model. Methods: This research has been worked out at animal house and Biomedical Laboratory of the Medical Faculty Andalas University. The design of this research was experimental study with post tes

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Degheidy, Heba A., Shahinaz M. Gadalla, Elizabeth Raveche, MA Stetler-Stevenson, and Gerald E. Marti. "Multimodal Bcl-2 Sub-Populations in CLL." Blood 114, no. 22 (2009): 4391. http://dx.doi.org/10.1182/blood.v114.22.4391.4391.

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Abstract Abstract 4391 Introduction The Recently described NZB miRNA15a/16-1 mutation is syntenic to 13q14 deletion in CLL. The mir15a/16-1 complex is thought to regulate bcl-2 expression. Therefore the level of bcl-2 expression was examined more closely as it might be used to differentiate mono-allelic deletion from the diploid CLL clone. Patients and Methods Multicolor flow-cytometry using a panel of anti-bcl-2 FITC (clone 124, DAKO Cytomation, Glostrup, Denmark) and CD19, CD20, CD5, CD23, CD38, kappa, lambda, and CD45 was used. Bcl-2 expression was evaluated using the conventional bcl-2 ind

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Walter, Patrick B., John Porter, Patricia Evans та ін. "Leukocyte Apoptosis and Mitochondrial Dysfunction in β-Thalassemia Patients Treated with Deferasirox or Deferoxamine." Blood 110, № 11 (2007): 2773. http://dx.doi.org/10.1182/blood.v110.11.2773.2773.

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Abstract Iron overload has been shown to increase mitochondrial dysfunction and apoptosis and may be implicated in leukocyte apoptosis. We assessed whether markers of leukocyte apoptosis and mitochondrial dysfunction are higher in iron-overloaded thalassemia patients compared with control subjects and whether improvement in the control of iron overload with deferasirox or deferoxamine (DFO) is associated with a change in the level of apoptotic markers. Methods: Thalassemia Clinical Research Network patients participating in the Novartis CICL670A0107 trial (a randomized comparison of deferasiro

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Wolter, Keith G., Yi-Te Hsu, Carolyn L. Smith, Amotz Nechushtan, Xu-Guang Xi, and Richard J. Youle. "Movement of Bax from the Cytosol to Mitochondria during Apoptosis." Journal of Cell Biology 139, no. 5 (1997): 1281–92. http://dx.doi.org/10.1083/jcb.139.5.1281.

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Bax, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown mechanism. Bax has been recently reported to be an integral membrane protein associated with organelles or bound to organelles by Bcl-2 or a soluble protein found in the cytosol. To explore Bcl-2 family member localization in living cells, the green fluorescent protein (GFP) was fused to the NH2 termini of Bax, Bcl-2, and Bcl-XL. Confocal microscopy performed on living Cos-7 kidney epithelial cells and L929 fibroblasts revealed that GFP–Bcl-2 and GFP–Bcl-XL had a punctate distribution and colocalized with a mitochon

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Persky, Daniel, Julie Teruya-Feldstein, Tarun Kewalramani, et al. "High Dose Chemoradiotherapy and ASCT Can Overcome the Prognostic Importance of Bcl-2, Bim, and p53 in Relapsed/Refractory Hodgkin’s Lymphoma." Blood 106, no. 11 (2005): 2073. http://dx.doi.org/10.1182/blood.v106.11.2073.2073.

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Abstract Introduction: Approximately twenty percent of patients with Hodgkin’s lymphoma (HL) relapse or have primary refractory disease. About 50% of these patients achieve long-term remissions after high-dose chemoradiotherapy and autologous stem cell transplantation (HDT/ASCT). At MSKCC, ICE (ifosfamide, carboplatin, etoposide) was incorporated as second-line chemotherapy prior to HDT/ASCT in a comprehensive treatment program. In addition to chemosensitive disease, a clinical prognostic model that emerged from this study identified 3 risk factors - B symptoms at relapse, extranodal disease,

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Melikova, Nigina I., and Umida A. Tashkenbaeva. "Impact of combination therapy on Ki-67 and Bcl-2 expression in psoriasis." Russian Journal of Skin and Venereal Diseases 26, no. 4 (2023): 375–82. http://dx.doi.org/10.17816/dv352496.

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BACKGROUND: Psoriasis is a chronic inflammatory immune-mediated disease characterized by an increased rate of keratinocyte division. Modern ideas about the immunopathogenesis of psoriasis, systemic inflammation and manifestations, comorbid conditions bring to the fore the question of the rational choice of therapy in patients with moderate and severe psoriasis. AIM: to study the effect of the combined use of PUVA therapy and methotrexate on the expression levels of receptors for the proliferation marker Ki-67 and the anti-apoptotic protein Bcl-2. MATERIALS AND METHODS: The study in

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Al-harbi, Sayer, Brian T. Hill, Suparna Mazumder, et al. "An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737." Blood 118, no. 13 (2011): 3579–90. http://dx.doi.org/10.1182/blood-2011-03-340364.

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Abstract The antiapoptotic BCL-2 proteins regulate lymphocyte survival and are over-expressed in lymphoid malignancies, including chronic lymphocytic leukemia. The small molecule inhibitor ABT-737 binds with high affinity to BCL-2, BCL-XL, and BCL-W but with low affinity to MCL-1, BFL-1, and BCL-B. The active analog of ABT-737, navitoclax, has shown a high therapeutic index in lymphoid malignancies; developing a predictive marker for it would be clinically valuable for patient selection or choice of drug combinations. Here we used RT-PCR as a highly sensitive and quantitative assay to compare

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Kurvinen, K., K. Syrjänen, and S. Syrjänen. "p53 and bcl-2 proteins as prognostic markers in human papillomavirus-associated cervical lesions." Journal of Clinical Oncology 14, no. 7 (1996): 2120–30. http://dx.doi.org/10.1200/jco.1996.14.7.2120.

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PURPOSE The present study was designed to analyze the expression of p53, mdm2, and bcl-2 proteins, with special emphasis on their association with the grade of squamous intraepithelial lesion (SIL), human papillomavirus (HPV) type, and clinical course of the disease. Special attention was focused on the value of individual protein expressions, as well as combined p53/mdm2 and p53/bcl-2 phenotypes, in predicting the clinical course of cervical lesions. MATERIALS AND METHODS The expression of p53, mdm2, and bcl-2 was studied immunohistochemically in a series of 98 HPV lesions of the uterine cerv

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Chiattone, Carlos, Marineide P. Carvalho, Roberto P. Paes, Karina C. B. Ribeiro, and Fernando Soares. "BCL2 Expression Is a Prognostic Marker for the Activated B-Cell-Like Type of Diffuse Large B-Cell Lymphoma." Blood 108, no. 11 (2006): 4635. http://dx.doi.org/10.1182/blood.v108.11.4635.4635.

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Abstract Diffuse large B-cell lymphoma (DLBCL) is heterogeneous both clinically and morphologically reflecting a mixture of underlying biologic or genetic differences. Therefore, it is important to identify at diagnosis biological markers which permit determination of subgroups with favorable or unfavorable evolution. The goal of this study was to evaluate the impact of BCL-2 tumor expression on overall survival (OS) in germinal center B-cell (GCB) and non-GCB subgroup. Patients and Methods. Seventy-four untreated pts (median age: 58 yrs: 36M/34F) with DLBCL de novo diagnosed in a single insti

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Bosch, F., P. Jares, E. Campo, et al. "PRAD-1/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma." Blood 84, no. 8 (1994): 2726–32. http://dx.doi.org/10.1182/blood.v84.8.2726.2726.

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Abstract The t(11;14)(q13;q32) translocation and its molecular counterpart bcl-1 rearrangement are frequently associated with mantle cell lymphomas (MCLs) and only occasionally with other variants of B-cell lymphoid malignancies. This translocation seems to activate the expression of PRAD-1/cyclin D1 gene located downstream from the major breakpoint cluster region of this rearrangement. However, the possible overexpression of this gene in other lymphoproliferative disorders independently of bcl-1 rearrangement is unknown. We have examined the overexpression of PRAD-1 gene in a large series of

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Bosch, F., P. Jares, E. Campo, et al. "PRAD-1/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma." Blood 84, no. 8 (1994): 2726–32. http://dx.doi.org/10.1182/blood.v84.8.2726.bloodjournal8482726.

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The t(11;14)(q13;q32) translocation and its molecular counterpart bcl-1 rearrangement are frequently associated with mantle cell lymphomas (MCLs) and only occasionally with other variants of B-cell lymphoid malignancies. This translocation seems to activate the expression of PRAD-1/cyclin D1 gene located downstream from the major breakpoint cluster region of this rearrangement. However, the possible overexpression of this gene in other lymphoproliferative disorders independently of bcl-1 rearrangement is unknown. We have examined the overexpression of PRAD-1 gene in a large series of 142 lymph

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Sumarni, Uly, Jiaqi Zhu, Tobias Sinnberg, and Jürgen Eberle. "Sensitivity of Cutaneous T-Cell Lymphoma Cells to the Mcl-1 Inhibitor S63845 Correlates with the Lack of Bcl-w Expression." International Journal of Molecular Sciences 23, no. 20 (2022): 12471. http://dx.doi.org/10.3390/ijms232012471.

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Long-term, curative treatment of cutaneous T-cell lymphomas (CTCL) remains a major challenge. Therapy resistance is often based on apoptosis deficiency, and may depend on antiapoptotic Bcl-2 proteins, such as Bcl-2, Bcl-xL, Bcl-w and Mcl-1. For their targeting, several antagonists have been generated, which mimic the Bcl-2 homology domain 3 (BH3 mimetics). As dysregulation and overexpression of Mcl-1 has been reported in CTCL, the use of Mcl-1 inhibitors appears as an attractive strategy. Here, we investigated the effects of the selective Mcl-1 inhibitor S63845 in a series of four CTCL cell li

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Wester, Tomas, Yngve Olsson, and Leif Olsen. "Expression of bcl-2 in Enteric Neurons in Normal Human Bowel and Hirschsprung Disease." Archives of Pathology & Laboratory Medicine 123, no. 12 (1999): 1264–68. http://dx.doi.org/10.5858/1999-123-1264-eobien.

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Abstract Objective.—The bcl-2 protein has the functional role of blocking apoptosis, ie, programmed cell death. This protein is widely expressed in the developing central and peripheral nervous systems. The purpose of this study was to map bcl-2 expression in the human enteric nervous system, as this has not previously been done. Methods.—Rectal specimens were obtained at autopsy of 13 fetuses at 13 to 31 weeks of gestation. Normal colon was also obtained from 5 children and 2 adults, and, in addition, ganglionic and aganglionic bowel resected in 11 patients with Hirschsprung disease was exami

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Kaur, Prabhjot, Bhaskar S. V. Kallakury, Christine E. Sheehan, Hugh A. G. Fisher, Ronald P. Kaufman, and Jeffrey S. Ross. "Survivin and Bcl-2 Expression in Prostatic Adenocarcinomas." Archives of Pathology & Laboratory Medicine 128, no. 1 (2004): 39–43. http://dx.doi.org/10.5858/2004-128-39-sabeip.

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Abstract Context.—Dysregulated cell proliferation caused by inhibitors of programmed cell death (apoptosis) contributes to tumor progression and spread. Aberrant expression of Bcl-2, the most notable inhibitor of apoptosis, has been well characterized in several human malignancies. Recent studies have described a novel apoptosis inhibitor, survivin, in human carcinomas, although its exact role remains to be characterized. Objective.—The purpose of this study was to evaluate the immunohistochemical expression of Bcl-2 and survivin proteins in prostate cancer and to correlate the results with cl

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