Academic literature on the topic 'Behavioural animal model'

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Journal articles on the topic "Behavioural animal model"

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Mellor, David J., Ngaio J. Beausoleil, Katherine E. Littlewood, et al. "The 2020 Five Domains Model: Including Human–Animal Interactions in Assessments of Animal Welfare." Animals 10, no. 10 (2020): 1870. http://dx.doi.org/10.3390/ani10101870.

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Throughout its 25-year history, the Five Domains Model for animal welfare assessment has been regularly updated to include at each stage the latest authenticated developments in animal welfare science thinking. The domains of the most up-to-date Model described here are: 1 Nutrition, 2 Physical Environment, 3 Health, 4 Behavioural Interactions and 5 Mental State. The first four domains focus attention on factors that give rise to specific negative or positive subjective experiences (affects), which contribute to the animal’s mental state, as evaluated in Domain 5. More specifically, the first
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Ramos, Fabiane Ochai, Luiz Renato Rodrigues Carreiro, Fulvio Alexandre Scorza, and Roberta Monterazzo Cysneiros. "Impaired executive functions in experimental model of temporal lobe epilepsy." Arquivos de Neuro-Psiquiatria 74, no. 6 (2016): 470–77. http://dx.doi.org/10.1590/0004-282x20160070.

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ABSTRACT Objective The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. Results Animals with
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Thiébot, M. H., P. Martin, and A. J. Puech. "Animal Behavioural Studies in the Evaluation of Antidepressant Drugs." British Journal of Psychiatry 160, S15 (1992): 44–50. http://dx.doi.org/10.1192/s0007125000296670.

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Animal behavioural models of psychiatric disorders cannot exactly simulate human psychopathology, but they can be used to evaluate the behavioural changes induced by drugs and to suggest hypotheses about the functions of the CNS and its involvement in psychiatric disorders. This should lead to a more heuristic classification of psychotropic drugs and to clarification of their therapeutic possibilities. The following animal models simulate aspects of depressive disorders and are sensitive to the antidepressant effects of drugs. (i) The forced swimming test: described as ‘behavioural despair‘ on
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Talamini, L. M., and B. Ellenbroek. "An animal model for neurodevelopmental disorders; behavioural evaluation." Schizophrenia Research 18, no. 2-3 (1996): 94–95. http://dx.doi.org/10.1016/0920-9964(96)85339-4.

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Lloyd, Kevin, and David S. Leslie. "Context-dependent decision-making: a simple Bayesian model." Journal of The Royal Society Interface 10, no. 82 (2013): 20130069. http://dx.doi.org/10.1098/rsif.2013.0069.

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Many phenomena in animal learning can be explained by a context-learning process whereby an animal learns about different patterns of relationship between environmental variables. Differentiating between such environmental regimes or ‘contexts’ allows an animal to rapidly adapt its behaviour when context changes occur. The current work views animals as making sequential inferences about current context identity in a world assumed to be relatively stable but also capable of rapid switches to previously observed or entirely new contexts. We describe a novel decision-making model in which context
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Baloba, Elijah B., and Baba Seidu. "A mathematical model of anthrax epidemic with behavioural change." Mathematical Modelling and Control 2, no. 4 (2022): 243–56. http://dx.doi.org/10.3934/mmc.2022023.

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<abstract><p>Anthrax is an acute infectious zonootic disease caused by <italic>Bacillus anthracis</italic>, a gram-positive, rod-shaped non-motile bacterium. It is a disease that mainly affects herbivorous animals of both domestic and wildlife, and causes devastating spillover infections into the human population. Anthrax epidemic results in serious and fatal infections in both animals and humans globally. In this paper, a non-linear differential equation model is proposed to study the transmission dynamics of anthrax in both animal and human populations taking into acc
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Jones, I. H., D. M. Stoddart, and J. Mallick. "Towards a Sociobiological Model of Depression a Marsupial Model (Petaurus breviceps)." British Journal of Psychiatry 166, no. 4 (1995): 475–79. http://dx.doi.org/10.1192/bjp.166.4.475.

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BackgroundThis is a sociobiological approach to depression using hierarchy and its hypothesised relevance to self-esteem in the marsupial sugar glider (Petaurus breviceps).MethodDifferential access to resources between the dominant and submissive animal is measured by observation in four stable colonies. The dominant animals from two of these colonies are then introduced into the other two, resulting in the transferred former dominants becoming subordinate. Behavioural and biochemical measures relevant to depression and involving access to resources are then repeated. These measures include ea
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Sedjahtera, Amelia, Lydia Gunawan, Lisa Bray, et al. "Targeting metals rescues the phenotype in an animal model of tauopathy." Metallomics 10, no. 9 (2018): 1339–47. http://dx.doi.org/10.1039/c8mt00153g.

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Kavitha, U., E. Kayalvizhi, K. Revathy, T. R. Brindha, R. Muthulakshmi, and M. Chandrasekar. "A systematic review on Valproate induced rat model of autism: Pathophysiology, treatment, developmental and neurobehavioral assessment of rat offsprings." Biomedicine 41, no. 1 (2021): 9–15. http://dx.doi.org/10.51248/.v41i1.526.

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Autism Spectrum disorder (ASD) is charecterised by certain degrees of disabilities in social communication, restrictive repetitive behaviour and altered motor and sensory perception. Translational research is carried out by creating animal models of autism to find out the correlation between behavioural changes and the pathology of brain tissue and for clinical trials of newer therapeutic formulations. Valproate induced animal model of autism has significant validity to demonstrate ASD manifestations. An early appreciation of ASD symptoms is needed for a better prognosis. So assessment of beha
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Fischer, B., M. Flint, K. Cole, and KA George. "Development of an evidence-based welfare approach for cheetahs (Acinonyx jubatus) under human care." Animal Welfare 30, no. 3 (2021): 295–306. http://dx.doi.org/10.7120/09627286.30.3.006.

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Societal concern for animals under human care has influenced our approaches to advance animal welfare in a variety of contexts. The Animal Programs Department at the Columbus Zoo and Aquarium sought partnership with the Center for Human-Animal Interactions Research & Education (CHAIRE) at The Ohio State University to develop a holistic welfare approach for the animals within their department using a focal species, the cheetah (Acinonyx jubatus). A one-year project using the Five Domains Animal Welfare Model collected data over six 60-day periods to evaluate long-term cortisol production an
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Dissertations / Theses on the topic "Behavioural animal model"

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Zhang, Xiaofan, and 張晓凡. "Behavioural and pharmacological study of an animal model relevant to schizophrenia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196435.

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Schizophrenia is a chronic, common and debilitating illness which causes serious psychosocial impairments. Despite the adverse impact of schizophrenia on public health, progress in understanding its pathophysiology is frustratingly slow, which hinders discovery of new therapeutic mechanisms. The major factors that have impeded this exploration are the complex neurobiology of higher brain function and the ethical and practical difficulties of investigating the living brain. Thus, animal models are useful to investigate the pathophysiology and therapeutics of schizophrenia and related conditions
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Reid, Rosemarie Esther. "An animal model of congenital hypothyroidism : behavioural characteristics and pharmacological interventions." Thesis, University of Ulster, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412131.

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Wang, Mu-Yun. "Attention and individual behavioural variation in small-brained animals, using bumblebees and zebrafish as model systems." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8700.

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A vital ability for an animal is to filter the constant flow of sensory input from the environment to focus on the most important information. Attention is used to prioritize sensory input for adaptive responses. The role of attention in visual search has been studied extensively in human and non-human primates, but is much less studied in other animals. We looked at attentional mechanisms, especially selective and divided attention where animals focus on multiple cues at the same time, using a visual search paradigm. We targeted bumblebee and zebrafish as model species because they are widely
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Rajagopal, Lakshmi. "Neonatal Phencyclidine (PCP) induced deficits in rats: A behavioural investigation of relevance to schizophrenia." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5404.

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Background: The main aim of the studies in this thesis is to provide insights into the neonatal phencyclidine (PCP) induced deficits in male and female rats as a neurodevelopmental animal model of schizophrenia. Methods: Both male and female rats were treated with neonatal PCP on postnatal days (PNDs) 7,9 and 11 or vehicle, followed by weaning on PND 21-22. The rats were then tested in behavioural paradigms such as novel object recognition, spatial memory and social interaction in their adolescent and adult stages and were also tested with acute treatment of typical and atypical antipsychotic
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Steensland, Pia. "Anabolic Androgenic Steroids and the Brain : Studies of Neurochemical and Behavioural Changes Using an Animal Model." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5192-6/.

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Lindberg, Julia. "Exploring Brain Gene Expression i Animal Models of Behaviour." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8177.

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Korff, Ané. "Extended characterisation and validation of an animal model of post-traumatic stress disorder : behavioural, molecular and pharmacological studies / Ané Korff." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1560.

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Kyeremanteng, Catherine. "The Biological and Behavioural Effects of Electroconvulsive Stimulus in Rodents: Investigation and Translational Implications of a Genetic Animal Model of Depression." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20694.

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Electroconvulsive therapy (ECT) is one of the oldest and most effective treatments for depression; however, its biological underpinnings are poorly understood. Brain-derived neurotrophic factor (BDNF) and the hypothalamic-pituitary-adrenal (HPA) axis are two chemical messenger systems implicated in the antidepressant action and cognitive side effects of ECT. The Wistar-Kyoto (WKY) strain is a genetic model of depression that shows biological, cognitive, behavioural, and treatment-response abnormalities, making it potentially a useful model in which to investigate the underpinnings of the actio
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Toua, Carl Christiaan. "Behavioural, pharmacological and neurochemical studies of social isolation rearing in rats / Carl Toua." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1941.

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Hsin-Wen, Hsieh Jennifer. "A study of an animal model of Attention-Deficit/ Hyperactivity Disorder using in vivo chronoamperometry and behavioural responses to methylphenidate and guanfacine." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/12368.

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Includes abstract.~Includes bibliographical references (leaves 119-147).<br>Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood disorder that is behaviorally characterized by developmentally inappropriate levels of inattention, impulsivity and hyperactivity. Among several hypotheses of ADHD etiology the prevailing hypothesis implicates a hypodopaminergic system due largely to the successes of the use of psychostimulants such as methylphenidate, that increase extracellular levels of dopamine (DA) and/or norepinephrine (NE) for the treatment of symptoms. In this study, the spontaneous
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Books on the topic "Behavioural animal model"

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Owen, John B., Janet L. Treasure, and David A. Collier, eds. Animal Models — Disorders of Eating Behaviour and Body Composition. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-015-9662-6.

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B, Owen John, Treasure Janet, and Collier David A, eds. Animal models - disorders of eating behaviour and body composition. Kluwer Academic Publishers, 2001.

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Paul, Willner, ed. Behavioural models in psychopharmacology: Theoretical, industrial, and clinical perspectives. Cambridge University Press, 1990.

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Wilson, Nigel Ernest. Some animal models of anxiety and muscle relaxation: A behavioural pharmacological evaluation and comparison. The author], 1990.

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Fitzpatrick, R. E. Modulation of anxiety-like behaviour in an animal model of depression by complex magnetic fields. Laurentian University, Department of Psychology, 2003.

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Halsey, Lewis George. The behavioural physiology of diving animals, in particular tufted ducks (Aythya fuligula), and the implications for models of optimal diving. University of Birmingham, 2003.

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F, Brain Paul, Mainardi Danilo, Parmigiani Stefano, and Ettore Majorana International Centre for Scientific Culture., eds. House mouse aggression: A model for understanding the evolution of social behaviour : proceedings of a course held at the International School of Medical Sciences, Ettore Majorana Centre for Scientific Culture, Italy, 10-15 September 1987. Harwood Academic Publishers, 1989.

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Wyatt, Tristram D. 7. The wisdom of crowds. Oxford University Press, 2017. http://dx.doi.org/10.1093/actrade/9780198712152.003.0007.

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Recent work on collective animal behaviour shows that relatively simple behaviours by each animal acting individually can together produce complex, emergent behaviours larger than the parts. This self-organization occurs despite the limited cognitive abilities of individual animals and despite each animal’s limited access to global information, or the ‘big picture’. ‘The wisdom of crowds’ explains this phenomenon termed swarm intelligence by considering the murmurations of starlings, schools of fish, ant trails, and termite nest-building. The behaviour of individual animals and the rules of in
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Wyatt, Tristram D. 2. Sensing and responding. Oxford University Press, 2017. http://dx.doi.org/10.1093/actrade/9780198712152.003.0002.

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How an animal behaves is coordinated by nerves and hormones in different, complementary ways. Stimuli, such as the sound of a predator, cause fast behavioural responses coordinated by nerve signals. The stimuli also cause longer lasting physiological changes via hormones, which release energy sources needed for the muscle action required for escape. ‘Sensing and responding’ considers the sensory responses of bats and moths, and then explains selective sensitivity—how animals evolve to detect only what affects their survival or reproductive success. It also shows how the study of neural circuit
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McNamara, John M., and Olof Leimar. Game Theory in Biology. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198815778.001.0001.

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Game theory in biology seeks to predict social behaviour and other traits that influence how individuals interact. It does this by tentatively assuming that current traits are stable endpoints of evolution by natural selection. The theory is used to model aggressive behaviour, cooperation, negotiation, and signalling, as well as phenotypic attributes like an individual’s sex and mating type. This book covers the basic concepts and the traditional examples of biological game theory. It expands the frontiers of the field, emphasizing the importance of the co-evolution of traits and the implicati
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Book chapters on the topic "Behavioural animal model"

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van der Heyden, J. A. M., B. Olivier, and T. J. J. Zethof. "The Behavioural Despair Model as a Predictor of Antidepressant Activity: Effects of Serotonergic Drugs." In Animal Models in Psychopharmacology. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-6419-0_19.

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van Dijken, H. H., J. A. M. van der Heyden, J. Mos, and F. J. H. Tilders. "Long-Lasting Behavioural Changes after a Single Footshock Stress Session. A Model of Depression?" In Animal Models in Psychopharmacology. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-6419-0_22.

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Schuurman, T., and J. Traber. "Old Rats as an Animal Model for Senile Dementia: Behavioural Effects of Nimodipine." In Diagnosis and Treatment of Senile Dementia. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-46658-8_23.

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Ketelaars, C. E. J., and J. Bruinvels. "Extinction of Conflict Behaviour." In Animal Models in Psychopharmacology. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-6419-0_11.

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Balkenius, Anna, Marie Dacke, and Christian Balkenius. "The Approach Behaviour of the Hawkmoth Manduca sexta toward Multi-modal Stimuli: A Simulation Model." In From Animals to Animats 11. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-15193-4_22.

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Kyriazakis, Ilias. "The Animal within: Lessons from the Feeding Behaviour of Farm Animals." In Animal Models — Disorders of Eating Behaviour and Body Composition. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-015-9662-6_5.

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Desor, D., C. Colin, F. Thuillier, J. Mos, and B. Krafft. "Experimental Social Differentiation in the Rat: Behavioural Characteristics in Wistar and Long-Evans Strains." In Animal Models in Psychopharmacology. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-6419-0_32.

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Lederer, R., J. Elsner, and G. Zbinden. "Animal Models in Behavioural Toxicology and Teratology." In Archives of Toxicology. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-74936-0_3.

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Mos, J., and B. Olivier. "Concepts in Animal Models for Pathological Aggressive Behaviour in Humans." In Animal Models in Psychopharmacology. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-6419-0_29.

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Everitt, Barry J. "Psychopharmacology and Sexual Behaviour: Uses and Limitations of Animal Models." In Animal Models in Psychopharmacology. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-6419-0_30.

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Conference papers on the topic "Behavioural animal model"

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Garcia, MM, D. Pascual, E. Quesada, JA Uranga, and C. Goicoechea. "SAT0494 Early toll-like receptor 4 blockade impedes the behavioural and histological characteristics observed in a mia-induced animal model of osteoarthritic pain." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.6022.

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Cliche, Francis, Jean-Marc Mac-Thiong, and Yvan Petit. "Anterior Spinal Cord Contusion on Porcine Model." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-38874.

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Animal models are commonly used to study spinal cord injuries (SCI). These models aim to better understand the traumatic behaviour of the spinal cord in vivo. However, experimental SCI models usually simulate a posterior contusion of the spinal cord on small animals, which do not reproduce completely the SCI mechanisms in humans. The objectives of the study are: 1) to develop an experimental anterior contusion of the spinal cord on porcine models, and 2) to compare biomechanical differences between ventral and dorsal approaches. A total of 6 specimens were tested in vivo with a drop weight ben
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Yang, Wen-Chi. "Integrating Diverse Evolutionary Patterns of Collective Animal Behaviours into a Unified Selfish Herd Model." In GECCO '24: Genetic and Evolutionary Computation Conference. ACM, 2024. http://dx.doi.org/10.1145/3638529.3654095.

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Scogings, Chris J., and Ken A. Hawick. "Modelling Predator Camouflage Behaviour and Tradeoffs in an Agent-based Animat Model." In Modelling and Simulation. ACTAPRESS, 2013. http://dx.doi.org/10.2316/p.2013.802-032.

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Dostálková, Iva. "Mathematical Model of Synchronization of Behaviour in the Group of N Animals." In NUMERICAL ANALYSIS AND APPLIED MATHEMATICS: International Conference on Numerical Analysis and Applied Mathematics 2008. American Institute of Physics, 2008. http://dx.doi.org/10.1063/1.2990881.

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Hoursan, Hesam, and Mohammad Taghi Ahmadian. "Dynamic Behaviour of Ox Tibial and Femoral Bones: A Comparison With Human Bones." In ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/detc2015-46555.

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Finite element models have been widely employed in an effort to quantify the stress and strain distribution around human bones as well as implanted prostheses and to explore the influence of these distributions on their long-term stability. In order to provide meaningful predictions, such models must contain an appropriate reflection of mechanical properties. Detailed geometrical and density information is now readily available from CT scanning. However, there are still many complications regarding patient-specific geometrical differences and bone dynamic behavior in-vivo. Experimental studies
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Dineva, Kristina, and Tatiana Atanasova. "RECOGNISING DAIRY COWS' BEHAVIOUR WITH LSTM MODEL TO IMPROVE FARM MANAGEMENT PRACTICES." In 23rd SGEM International Multidisciplinary Scientific GeoConference 2023. STEF92 Technology, 2023. http://dx.doi.org/10.5593/sgem2023v/6.2/s25.43.

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This paper focuses on recognizing the activity of dairy cows using a non-invasive approach that monitors four key behaviors: licking, feeding, standing, and lying. The study used IoT devices with accelerometers and gyroscopes attached to the cow's neck to continuously monitor its movements. The data collection process aimed to capture the dynamic and static nature of dairy cow behaviors, providing a valuable data set for subsequent analysis. To efficiently process the raw data, we analyzed it and then used long short-term memory (LSTM) neural networks, a type of recurrent neural network (RNN)
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Khere, A., A. Kiapour, A. Seth, et al. "A Finite Element Assessment to Compare the Biomechanical Behaviour of Human, Sheep and Chagma Baboon Functional Spine Units." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176679.

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Ideal animal spine models have been used by researchers to compare and evaluate the biomechanical behavior of spine following surgery and implantation due to the growing difficulty in obtaining fresh human spine specimens. Availability and resemblance of sheep and baboon spines to human spine make them suitable for use in biomechanical studies; however the literature on biomechanics of baboon and sheep spine compared to human spine is sparse. In the present study finite element method was used to compare the load transfer and load-displacement characteristics of L3-L4 sheep, baboon and human s
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Al-Rawi, M. A., and A. M. Al-Jumaily. "Acoustics and Computational Models for Diagnosing Arterial Blockages." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-63316.

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Arterial blockages can occur in small or large arteries for a variety of reasons, such as obesity, stress, smoking and high cholesterol. This paper presents a feasibility study on a novel method to detect the behaviour of the blood pressure wave propagation for arteries in both healthy and diseased conditions in order to develop a relatively inexpensive method for early detection of arterial disease. The trend of this behaviour is correlated to the early development of the arterial blockage at various locations. Invasive sets of data (gathered from experiments performed on animals) are impleme
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Capelli, Claudio, Giovanni Biglino, Lorenza Petrini, et al. "Different Finite Element Strategies to Satisfy Clinical and Engineering Requirements in Modeling a Novel Percutaneous Device." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80283.

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By taking into account patient-specific properties, finite element (FE) models can aid in the optimization of the devices’ mechanical performances, accelerating the time of development and reducing testing costs. Patient-specific cardiovascular modeling can also drive the development of novel devices [1], by means of anatomical elements that are more representative than animal surrogates [2], and integrating standard in vitro tests with patient-specific loading conditions [3]. Transcatheter heart valve implantation can particularly benefit from a modeling approach. In the field of treatment of
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Reports on the topic "Behavioural animal model"

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Shrestha, Tanuja, Mir A. Matin, Vishwas Chitale, and Samuel Thomas. Exploring the potential of deep learning for classifying camera trap data: A case study from Nepal - working paper. International Centre for Integrated Mountain Development (ICIMOD), 2023. http://dx.doi.org/10.53055/icimod.1016.

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Data from camera trap networks provide crucial information on various important aspects of wildlife presence, movement, and behaviour. However, manual processing of large volumes of images captured is time and resource intensive. This study explores three different approaches of deep learning methods to detect and classify images of key animal species collected from the ICIMOD Knowledge Park at Godavari, Nepal. It shows that transfer learning with ImageNet pretrained models (A1) can be used to detect animal species with minimal model training and testing. These methods when scaled up offer tre
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Chamovitz, Daniel A., and Albrecht G. Von Arnim. eIF3 Complexes and the eIF3e Subunit in Arabidopsis Development and Translation Initiation. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7696545.bard.

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The original working hypothesis of our proposal was that The “e” subunit of eIF3 has multiple functions from both within the nucleus and in the cytoplasm. Within this model, we further hypothesized that the “e” subunit of eIF3 functions in translation as a repressor. We proposed to test these hypotheses along the following specific aims: 1) Determine the subcellular localization of the interaction between eIF3e and other eIF3 subunits, or the COP9 signalosome. 2) Elucidate the biological significance of the varied subcellular localizations of eIF3e through generating Arabidopsis eIF3e alleles
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