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Journal articles on the topic 'Benefits of extended-release tablet'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chandra, Prakash Sunuwar* Meenakshi Kandwal Shivanand Patil. "A Review on Formulation and Evaluation of Mirabegron Extended-Release Tablets." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4859–65. https://doi.org/10.5281/zenodo.15547921.

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A type of modified-release dosage form known as an extended-release (ER) tablet is designed to release the active pharmaceutical ingredient (API) gradually over a long period of time. The human body metabolizes and excretes drugs at different rates. Fast drug absorption may result in peak plasma concentrations that could be harmful, whereas fast clearance in conventional formulations causes subtherapeutic levels that necessitate frequent dose. Extended-release formulations get around these issues and ensure a long-lasting therapeutic effect by modifying the kinetics of medicine release. This s

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Chandan, Singh* Rita Saini Shivanand Patil. "A Review of Bilayer Tablet Technology Immediate and Extended-Release Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4491–503. https://doi.org/10.5281/zenodo.15534239.

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Compared to monotherapy (traditional dosage forms), combination therapy is more common and has several benefits.  The best and most recent example of mixed dose formulation is bilayer tablet technology. The pharmaceutical industry has seen a rise in single-dose formulation that combines 2 or 3 molecules within the tablets. By lowering the number of dosages and increasing the bioavailability of dosage forms, it is well known for encouraging patient convenience and compliance.  Innovative variations of traditional oral drug delivery technologies are bilayer or multilayer tablets. The o

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Lin, Wen, Yinke Li, Qiongzhi Shi, et al. "Preparation and evaluation of bilayer-core osmotic pump tablets contained topiramate." PLOS ONE 17, no. 2 (2022): e0264457. http://dx.doi.org/10.1371/journal.pone.0264457.

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Topiramate (TPM) was an antiepileptic agent commonly used in clinical. Studies showed that an oral preparation of TPM with extended-release manner could bring some benefits for epileptics. In this paper, controlled release push-pull osmotic pump (PPOP) tablets of sparingly water-soluble TPM were successfully prepared. This bi-layer tablet core mainly consisted of sodium chloride as osmotic promoting agent and polyethylene oxide as suspending and pushing agents. The influences of osmotic agents, pushing agents and the compositions of coating membrane on TPM release profiles were evaluated. An o

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Galankar, Vipulata P., Ganesh D. Basarkar, Chandrashekhar D. Upasani, and Sunil V. Amrutkar. "Indomethacin-Loaded Nanosponges for Oral Delivery: Formulation Strategy, Optimization, and In-vitro Evaluation." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–07. https://doi.org/10.25258/ijddt.15.2.15.

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Chronic illnesses like arthritis cause pain and inflammation, requiring extended oral analgesic therapy. To reduce adverse reactions, active pharmaceutical ingredients are administered through sustained-release dosage forms. However, methods like matrix tablets, osmotic systems, and ion exchange resins have limitations. Nanotechnological approaches like nanosponges improve precision and accuracy in medication release manufacturing. Encapsulated formulations offer benefits like reduced side effects, varied dose options, non-irritating properties, and aesthetic appeal. Nanosponges are used in fo

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NIZAMI, FARIDA, and YOGENDRA MALVIYA. "RECENT ADVANCEMENT AND CHALLENGES IN BILAYER TABLET TECHNOLOGY: AN OVERVIEW." Current Research in Pharmaceutical Sciences 11, no. 4 (2022): 91–97. http://dx.doi.org/10.24092/crps.2021.110401.

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Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermin

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Jayashree, Bhamre* Shraddha Bhavsar Dr. Gokul Talele Bhushan Shewale. "A Systematic Review on Sustained Release Matrix Tablet." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 2555–64. https://doi.org/10.5281/zenodo.13212215.

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The abstract of the document provides an overview of sustained release drug delivery systems. It emphasizes the goal of delivering therapeutic levels of drugs to specific body sites over extended periods. The document discusses the increasing interest in sustained release systems due to high costs of developing new drugs, patent expirations, discovery of new polymers, and improvements in therapeutic efficiency and safety. Various types of matrix tablets, such as hydrophilic, fat-wax, plastic, biodegradable, and mineral matrices, are classified based on their properties and methods of drug rele

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Khobragade, Deepak S., K. Vighneshwar, and Mrunali S. Potbhare. "Development and Evaluation of Novel Multi-unit Pellet System Formulation of Metoprolol Succinate for Extended Release." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1219–27. http://dx.doi.org/10.25258/ijddt.12.3.49.

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Metaprolol succinate is a highly water-soluble drug with extensive first-pass metabolism. It needs to be administered about 3-4 times a day for optimum therapeutic effect. Conventional extended-release formulations are available but have their own disadvantages. The study was to designed formulate and evaluate the prolonged-release compressed multiple-unit pellet system of Metoprolol succinate. MUPS are novel formulations with benefits of both single and multi unit dosage forms and can provide extended drug delivery release profile and increase the efficiency profile of the drug. Metaprolol su

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P, Pavazhaviji, and Rajalakshmi A. N. "FIXED-DOSE COMBINATION DRUGS AS TABLET IN TABLET: A REVIEW." International journal of multidisciplinary advanced scientific research and innovation 1, no. 9 (2021): 169–77. http://dx.doi.org/10.53633/ijmasri.2021.1.9.02.

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The Pharmaceutical industry has become more interested in developing fixed-dose combinations (FDCs) in recent years. FDCs have been used successfully in a variety of clinical areas, including diabetes, HIV/AIDS,and cardiovascular diseases etc. FDCs are intended to extend the product life cycle and enhance patient compliance by decreasing cost. Active Pharmaceutical ingredients are chosen for FDC development based on variety of purposes such as Pharmacokinetic profile, drug-drug interactions, mechanism of action, and manufacturability for successful development. Tablet in tablet technology has

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Sadhu, Venkateswara Rao, Priyanka Bopparaju, and Padmalatha Kantamneni. "Bilayer tablet technology: A novel approach." GSC Biological and Pharmaceutical Sciences 7, no. 2 (2019): 022–28. https://doi.org/10.5281/zenodo.4286145.

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Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second lay

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Yadav, Vimal Kumar. "Matrix tablets: benefits, drawbacks and hopes for the future." International journal of therapeutic innovation 1, no. 3 (2023): 75–78. http://dx.doi.org/10.55522/ijti.v1i3.0018.

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The adaptability of matrix tablets, a common drug delivery technology, in regulated and sustained release has drawn a lot of attention in pharmaceutical research and development. The different facets of matrix tablets are examined in this abstract, along with their formulations, benefits, drawbacks, and potential applications. We talked about matrix tablet formulations, benefits, drawbacks, and potential future developments in this review study.

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Sadhana, Shahi, B. Barkate Manoj, A. Shete Nikita, and N. Bobade Manjari. "A Review on Multi-layered Tablets: A way to control the drug release." AMERICAN JOURNAL OF PHARMACY AND HEALTH RESEARCH 11, no. 01 (2023): 1–18. https://doi.org/10.5281/zenodo.7807820.

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ABSTRACT Due to necessities their affordable manufacturing costs and simplicity of administration, especially in controlled-release applications, tablet dosage forms have traditionally been chosen over other formulations for oral medication delivery. Over monotherapy, combination therapy has a number of benefits. The pharmaceutical industry has grown more interested in recent years in creating dosage forms (monolithic, bilayer, or multi-layered tablets) that combine two or more Active Pharmaceutical Ingredients (API), improving patient convenience and compliance. The active pharmaceutical ingr

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Gandhi, Kunjan, Sunil Kumar Shah, C. K. Tyagi, Prabhakar Budholiya, and Harish Pandey. "Formulation, Development and Evaluation of Uncoated Bilayer Tablet of Anti-Hypertensive Agents." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 100–107. http://dx.doi.org/10.22270/jddt.v10i4-s.4229.

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The present research work was carried out to Formulate and evaluation of bilayer tablet dosage form for the treatment of Hypertension.The objective of this study to compare the specific characteristics of Metoprolol [beta selective (cardio selective) adrenoreceptor blocking agent] and Hydrochlorothiazide (Thiazide Diuretics]) in order to design stable formulation. It can be concluded that bilayer tablet were successfully formulated to achieve immediate release of Hydrochlorothiazide (HCTZ) and tailored release of Metoprolol (MPL)by using Dual Release Drug Absorption System(DUREDAS technology).

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Shekhar, Sashank, Alok Kumar, Vinod Rana, Roshan Kumar, Chavi Mittal, and Kanchan Tariyal. "Recent Approaches of Matrix Release Tablet in NDDS System." Journal for Research in Applied Sciences and Biotechnology 2, no. 3 (2023): 64–71. http://dx.doi.org/10.55544/jrasb.2.3.9.

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The purpose of this analysis is to categorize matrix tablets according to the kind of polymer they are made of as well as the rate at which they release their contents. When it came to medicinal applications, the matrix system was the very first oral extended release platform ever developed. The utilization of matrix tablets enables the modification of drug release characteristics. They are highly favored for this kind of treatment because of the benefits they give for the patient in terms of better adherence to the treatment, more stable medication levels, decreased dose and bad effects, and

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Deore, Rutuja, Khemchand Surana, Rushikesh Bachhav, Sunil Mahajan, and Deepak Sonawane. "Formulation, Development, and Evaluation of Flubiprofen Sustained Release Tablets Using a Quality-by-Design Approach." Ars Pharmaceutica (Internet) 66, no. 2 (2025): 139–51. https://doi.org/10.30827/ars.v66i2.31527.

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Introduction: Flurbiprofen acts by blocking the cyclooxygenase (COX) enzymes in your body from carrying out their normal function. The study made flubiprofen tablets that last a long time by directly compressing them with carbopol, HPMC K100M, and HPMC K4M polymers. An anti-inflammatory non-steroid is flubiprofen. Method: The research formulates and develops sustained-release flubiprofen tablets by direct compression with carbopol, HPMC K100M, and HPMC K4M polymers. The highest flubiprofen concentration in ethanol, according to pre-formulation tests, was 215 nm. Results: The compressibility ta

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Amit, Pareek, and Kumar Gupta Mukesh. "An Overview of The Bilayer Tablet." International Journal of Current Pharmaceutical Review and Research 14, no. 4 (2022): 106–10. https://doi.org/10.5281/zenodo.7612899.

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In the history of the development of the controlled release formulation, the introduction of bilayer tablets marked the beginning of a new age. This innovation, in alongside other factors, has made it possible to successfully provide medications to the body. Through the use of physical separation, such as bilayer tablets, it is possible to prevent chemical incompatibilities between API. Additionally, new pharmaceutical release patterns may be developed. This article provides an overview of the most recent developments in the technology behind bilayer tablets, with a primary emph

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Bhuyar, Sajali R., Manjiri M. Auti, Shubhangi A. Bhise, et al. "Innovations and advancements in floating tablet drug delivery systems: a comprehensive review." Pharmacy & Pharmacology International Journal 12, no. 5 (2024): 195–200. https://doi.org/10.15406/ppij.2024.12.00452.

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Floating tablets, also known as gastro retentive drug delivery systems (GRDDS), are innovative formulations designed to prolong the retention of drugs in the gastrointestinal tract, particularly the stomach. This approach is highly beneficial for medications with a narrow absorption window in the upper GI tract, requiring extended action or optimal absorption in a specific pH range. The floating mechanism helps improve bioavailability, therapeutic efficacy, and offers controlled drug release, reducing dosage frequency. The formulation of floating tablets typically involves hydrophilic polymers

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Vijay, Kumar R.*1 Vikram T. Choudhary2 Gururaj S. Kulkarni3 Padmaa Paarak4. "Advancements In Sintered Tablet Technology : A Comprehensive Review." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 811–24. https://doi.org/10.5281/zenodo.13770632.

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The pharmaceutical industry has found that sintering tablets is a potential method for creating solid dosage forms with better drug delivery properties. An extensive summary of the most current developments in sintered tablet technology is given in this article. The study starts out by explaining the basics of sintering with an emphasis on the production procedures, formulation techniques, a variety of sintering techniques are covered, including traditional thermal sintering and cutting-edge approaches like microwave and laser sintering. Their benefits and drawbacks in the production of tablet

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Tyagi, Puneet, Chandresh Patel, Kimberly Gibson, et al. "Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation." Pharmaceutics 15, no. 10 (2023): 2436. http://dx.doi.org/10.3390/pharmaceutics15102436.

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Oral delivery of peptides and biological molecules promises significant benefits to patients as an alternative to daily injections, but the development of these formulations is challenging due to their low bioavailability and high pharmacokinetic variability. Our earlier work focused on the discovery of MEDI7219, a stabilized, lipidated, glucagon-like peptide 1 agonist peptide, and the selection of sodium chenodeoxycholate (Na CDC) and propyl gallate (PG) as permeation enhancer combinations. We hereby describe the development of the MEDI7219 tablet formulations and composition optimization via

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Arnal, M. E., S. Denis, O. Uriot, et al. "Impact of oral galenic formulations of Lactobacillus salivarius on probiotic survival and interactions with microbiota in human in vitro gut models." Beneficial Microbes 12, no. 4 (2021): 381–96. http://dx.doi.org/10.3920/bm2020.0187.

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Health benefits of probiotics in humans essentially depend on their ability to survive during gastrointestinal (GI) transit and to modulate gut microbiota. To date, there is few data on the impact of galenic formulations of probiotics on these parameters. Even if clinical studies remain the gold standard to evaluate the efficacy of galenic forms, they stay hampered by technical, ethical and cost reasons. As an alternative approach, we used two complementary in vitro models of the human gut, the TNO gastrointestinal (TIM-1) model and the Artificial Colon (ARCOL), to study the effect of three or

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Miller, Aaron, Amy Perrin Ross, and James Gilbart. "Dalfampridine Extended Release Tablets—Clinical Need and Use." US Neurology 06, no. 02 (2010): 76. http://dx.doi.org/10.17925/usn.2010.06.02.76.

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Walking impairment is one of the most serious and frequent problems reported by multiple sclerosis (MS) patients. Treatments to restore walking ability are an unmet clinical need. Dalfampridine, a potassium channel blocker, is the first US Food and Drug Administration (FDA)-approved drug to be indicated specifically to improve walking in patients with MS. In clinical trials the drug showed improved walking speeds, demonstrating efficacy in all four types of MS. In phase III trials, dalfampridine provided significant benefits to 35–43% of treated patients. Therefore, it will be critical to mana

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Lamkhade, Snehal* Shelke Pranali Dr. Wakale Vijaykumar S. "A Brief Review on Quinine Sulphate Sustained Release Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4558–64. https://doi.org/10.5281/zenodo.15527245.

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Malaria continues to pose a significant global health burden, particularly in developing regions with limited healthcare access. Conventional antimalarial therapies, while effective, suffer from limitations such as short drug half-lives, poor patient compliance, and the rising threat of drug resistance. In response to these challenges, sustained release (SR) tablet formulations are emerging as a promising strategy to optimize antimalarial drug delivery. This review paper presents a comprehensive overview of the formulation approaches, materials used, pharmacokinetic benefits, and clinical impl

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Kamal, Kamal Kant, Ashutosh Sharma, Mayank Bansal, and Vishal Choudhary. "Design and evaluation of bi-layered tablet of Ramipril and hydrochlorothiazide for the Treatment of hypertension." Journal of Biomedical and Pharmaceutical Research 14, no. 3 (2025): 38–41. https://doi.org/10.32553/jbpr.v14i3.1320.

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Hypertension is a widespread cardiovascular disease that requires effective management through combination therapy. The complexity of hypertension necessitates a multifaceted approach, often involving the concurrent administration of multiple antihypertensive agents. This study aims to design, formulate, and evaluate bi-layered tablets of Ramipril and Hydrochlorothiazide, leveraging the benefits of sequential drug release and stability enhancement. The bi-layer tablet formulation comprises an immediate-release layer for rapid therapeutic onset and a sustained-release layer for prolonged plasma

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Amit, Pareek, and Kumar Gupta Mukesh. "An Overview of The Bilayer Tablet." International Journal of Current Pharmaceutical Review and Research 14, no. 04 (2022): 106–10. https://doi.org/10.5281/zenodo.12657682.

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In the history of the development of the controlled release formulation, the introductionof bilayer tablets marked the beginning of a new age. This innovation, in alongside otherfactors, has made it possible to successfully provide medications to the body. Through the useof physical separation, such as bilayer tablets, it is possible to prevent chemicalincompatibilities between API. Additionally, new pharmaceutical release patterns may bedeveloped. This article provides an overview of the most recent developments in thetechnology behind bilayer tablets, with a primary emphasis on the most sign

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Majeed, Saad M., Mohammed K. Al-Shaheen, Radhwan Nidal Al-Zidan, and Sameer M. Mahmood. "Multiple Unite Pellet Systems (MUPS) as Drug Delivery model." Journal of Drug Delivery and Therapeutics 10, no. 6 (2020): 231–35. http://dx.doi.org/10.22270/jddt.v10i6.4389.

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Multiparticulate drug delivery systems are mainly oral dosage form, consist of small discrete units that exhibit different characteristics especially in release pattern and drug bioavailability. These systems are represented by granules, pellets, microspheres, microcapsules, and minitablets. Pellets offer high flexibility in the design, formulation, and development of oral dosage forms such as sachet, suspension, capsule, and tablet. Multiparticulate tablets manufactured by compaction of multiple unite pellets is one of the latest and, yet, challenging technologies. Multiparticulate tablets co

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Khizer, Zara, Muhammad R. Akram, Muhammad Azam Tahir, et al. "Personalised 3D-Printed Mucoadhesive Gastroretentive Hydrophilic Matrices for Managing Overactive Bladder (OAB)." Pharmaceuticals 16, no. 3 (2023): 372. http://dx.doi.org/10.3390/ph16030372.

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Overactive bladder (OAB) is a symptomatic complex condition characterised by frequent urinary urgency, nocturia, and urinary incontinence with or without urgency. Gabapentin is an effective treatment for OAB, but its narrow absorption window is a concern, as it is preferentially absorbed from the upper small intestine, resulting in poor bioavailability. We aimed to develop an extended release, intragastric floating system to overcome this drawback. For this purpose, plasticiser-free filaments of PEO (polyethylene oxide) and the drug (gabapentin) were developed using hot melt extrusion. The fil

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Monicha, Edtyva, Akmal Djamaan, Rini Agustin, and Rusmana Wijaya Setia Ningrat. "Pembuatan dan Karaterisasi Tablet NPN Lepas Lambat Berlapis Polikaprolakton Sebagai Suplement Ruminansia." Journal of Pharmaceutical and Health Research 4, no. 2 (2023): 212–19. http://dx.doi.org/10.47065/jharma.v4i2.3642.

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Productivity of ruminant cattle can be increased by providing non-protein nitrogen, especially urea. Urea not only has benefits as a plant fertilizer, but is also used as a substitute for nitrogen sources for ruminants. The purpose of this research is to use urea more efficiently because urea in the rumen is degraded more quickly to form ammonia so that urea excretion becomes faster in the urine. In this study it was designed so that urea is released in a slow release, its use is more practical and the dosage is correct. The method used is to make urea tablets and then coat them with a coating

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Priyanka, Priyanka, Kapil Kumar, and Deepak Teotia. "A comprehensive review on pharmaceutical mini tablets." Journal of Drug Delivery and Therapeutics 8, no. 6 (2018): 382–90. http://dx.doi.org/10.22270/jddt.v8i6.2060.

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Mini-tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less. Offering some therapeutic benefits such as dose flexibility and combined release patterns. They do not require any solvent for their production and also local irritation can be avoided by the use of mini tablet Mini tablet offer several advantages like they can be manufactured relatively easily, They

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Dr N Swathi, Dr N. Swathi, J. Madhuritha J. Madhuritha, K. Anusha K. Anusha, S. Kavya S. Kavya, Ch Leena Ch. Leena, and V. Poojitha V. Poojitha. "Formulation and in-vitro evaluation of Gastro retentive floating tablets of Cefixime Trihydrate by using Natural Polymers." International Journal of Pharmaceutical Science Invention 14, no. 3 (2025): 35–46. https://doi.org/10.35629/6718-14033546.

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The Floating drug delivery system is a novel approach in the Gastro retentive drug delivery systems (GRDDS). Floating system is needed for those drugs having a stomach or upper small intestine absorption window. This process does not affect on the rate of gastric emptying over an extended time as it a less dense method and therefore stay buoyant in the stomach and slowly release the drug. System floats on the gastric contents thereby releasing the drug slowly at a desired rate from the system which results in an increased gastric residence time (GRT) and a better control of the fluctuations in

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Kalam, Sonali, Rupali Chaure, Poonam Dapke, et al. "Formulation and Evaluation of Herbal Tablets for the Treatment of PCOD using Kanchnar and Shatavari." Asian Journal of Pharmaceutical Research and Development 12, no. 4 (2024): 37–42. http://dx.doi.org/10.22270/ajprd.v12i4.1438.

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Herbal tablets have been crucial in managing and preventing illnesses for centuries. Across cultures, herbs have advanced healthcare, leading to detailed herbal pharmacopeias. Integrating into mainstream healthcare, herbal tablets, especially Ayurvedic ones, are made from natural ingredients like Kanchanara and Shatavari, which are effective against Polycystic Ovary Disease (PCOD) by regulating cyst size and balancing hormones. Excipients in tablet formulations ensure correct dosage, integrity, and effective drug release. This underscores the growing importance of herbal medicine in modern hea

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Nikita, Bhosale, Velhal Atish, Redasani Vivek Kumar, Raut Poonam, and Varda Joshi. "An Overview Onsustained Release Formulations Using Solid Dispersion as Solubility Enhancement Technique." Asian Journal of Pharmaceutical Research and Development 11, no. 3 (2023): 84–91. http://dx.doi.org/10.22270/ajprd.v11i3.1257.

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Biopharmaceutical classification system is important for determining the bioavailability of the drug. Drugs that dissolve slowly in water can be effectively solid-dispersed to increase their bioavailability. The bioavailability issue can be due to insufficient solubility of permeability. The poorly water-soluble medication dissolves more quickly when combined with the water-soluble carriers used to make solid dispersion. The review paper concentrates on the preparation techniques, benefits, drawbacks, and characterization of solid dispersion. Pharmaceuticals with sustained release have recentl

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Pratiksha, Jagtap Vaibhav Changediya. "Formulation Development And Evaluation Of Mentha Spicata Leaf Powder Orodispersible Tablet." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 566–82. https://doi.org/10.5281/zenodo.13920434.

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This research was focuses on the formulation development and evaluation of Oro-dispersible tablets (ODTs) containing Mentha spicata leaf powder, aiming to explore its potential as a novel herbal formulation for oral administration. Mentha spicata, commonly known as spearmint, possesses various pharmacological properties, including antimicrobial, antioxidant, and anti-inflammatory effects, which make it a promising candidate for pharmaceutical applications. The formulation process involves the wet granulation method for Mentha spicata leaf powder tablet. The Tablet was evaluated for its physica

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saha, Dr Nansri. "Formulation and Evaluation of Amoxicillin Oral Tablets for Suspension for Pediatric Patients." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 1034–49. https://doi.org/10.35629/4494-090610341049.

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The formulation and evaluation of amoxicillin oral tablets for suspension aimed at pediatric patients involves the development of an innovative dosage form that ensures ease of administration, accurate dosing, and improved therapeutic efficacy. Amoxicillin, a broad-spectrum antibiotic, is commonly used to treat bacterial infections in children; however, pediatric patients often face difficulties with swallowing conventional tablets. The primary objective of this study was to design and evaluate an oral tablet that can be reconstituted into a suspension for easier administration in younger pati

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Shrikant, S. Dongare* Mr. Dnyaneshwar S. Vyavhare Dr. Megha T. Salve. "Concept And Recent Advancement In Tablet Coating Technologies: A Comprehensive Review." International Journal in Pharmaceutical Sciences 1, no. 11 (2023): 496–506. https://doi.org/10.5281/zenodo.10207162.

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Tablet coating, an enduring pharmaceutical process, involves the application of a dry outer layer to confer specific benefits on the dosage form, such as taste and odor masking, physical and chemical protection, protects the drug from the gastric surroundings, and control over release profiles. This technique, applicable to various solid oral forms, including particles, powders, granules, crystals, pellets, and tablets, employs a sugar or polymeric coat.  Traditional methods, like sugar coating, film coating, and enteric coating, were once prevalent, but recent advancements have circumven

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Spina, Edoardo, and Rosalia Crupi. "Safety and Efficacy of Paliperidone Extended-Release in Acute and Maintenance Treatment of Schizophrenia." Journal of Central Nervous System Disease 3 (January 2011): JCNSD.S1607. http://dx.doi.org/10.4137/jcnsd.s1607.

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Paliperidone, the major active metabolite of risperidone, is a second-generation antipsychotic that has been developed as an extended-release (ER) tablet formulation that minimizes peak-trough fluctuations in plasma concentrations, allowing once-daily administration and constant drug delivery. Paliperidone ER has demonstrated efficacy in the reduction of acute schizophrenia symptoms in 6-week, placebo-controlled, double-blind trials and clinical benefits were maintained in the longer-term according to extension studies of up to 52 weeks in duration. Compared with quetiapine, paliperidone ER wa

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Shraddha, Mali*1 Nilesh Khutle2 Sarita More3 Swapnil Phalak4. "Formulation Science of Effervescent Tablets: From Manufacturing to Release Kinetics." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 929–44. https://doi.org/10.5281/zenodo.15350690.

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Oral dosage forms are the most often used method of administering medication, they have certain drawbacks, such as a slower rate of absorption. By consuming liquid dose forms, this can be avoided. The majority of APIs, however, have been discovered to be unstable in liquid formulation. An alternate approach to creating a dosage form that can accelerate the dispersion and degradation of medications is the effervescent technique. Because of their quick onset of action and ease of administration, effervescent tablets are growing in popularity. Usually, they comprise acidic substances and carbonat

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Pawar, Nita, Prapti Desai, Kalyani Jadhav, Pranita Shah, and Sujata N. Shrotri. "Formulation and Evaluation of Bilayer Tablets of Granisetron HCl and Ibuprofen for the Treatment of Migraine." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 5 (2024): 7596–604. https://doi.org/10.37285/ijpsn.2024.17.5.6.

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Background of the Topic: The major purpose of this study was to produce a bilayer pill that contained Granisetron HCl (GSH) and ibuprofen (IBF) in distinct layers to minimize the possibility of adverse drug interactions and maximize the efficacy of both medications when they were combined to treat the symptoms of migraines. In contrast to the IBF layer, the GSH layer was intended to have a more gradual release of its contents. Methods: Microcrystalline cellulose, sodium starch glycolate, and croscarmellose sodium were the chemicals used to create the rapid-release layer. Isopropyl alcohol, mag

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Singh, Shubham, Anand Chaurasia, Naveen Gupta, and Dharmendra Singh Rajput. "Effect of Formulation Parameters on Enalapril Maleate Mucoadhesive Buccal Tablet Using Quality by Design (QbD) Approach." Chinese Journal of Applied Physiology 40 (2024): e20240003. http://dx.doi.org/10.62958/j.cjap.2024.003.

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The buccal route has great prospects and possible benefits for the administration of drugs systemically. The present study involves designing, developing and optimising the buccal tablet formulation of Enalapril Maleate (EM) by using the QbD approach. We prepared the EM buccal tablets using the dry granulation method. In the QTPP profile, the CQAs for EM buccal tablets are Mucoadhesive strength, swelling index and drug release (dependent variables); the CMAs identified for EM buccal tablets were Carbopol 934P, HPMC-K100M and chitosan (independent variables). Diluent quantity, blending time and

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Deshmukh, Komal* Narsale Somanath Salve Bhumika Chavan Rutuja. "A Review on Formulation and Evaluation of Effervescent Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4428–38. https://doi.org/10.5281/zenodo.15521939.

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Although there are certain drawbacks to oral dosage forms compared to alternative approaches, such as the possibility of drug absorption, these can be addressed by providing the medicine in a liquid form, potentially enabling the use of lower dosages. Oral dosage forms are the most often used form of medication. However, many medications' volatility in liquid dose form limits their use. Creating effervescent tablets or granules, which are typically employed in quick-release arrangements, is an alternative to creating a dosage form that might hasten the dispersion and degradation of medications

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Twinkie Yadav, Twinkie Yadav, Rizwana Khan Rizwana Khan, Bhawna Sharma Bhawna Sharma, and Priyanka Priyanka. "An Overview on Floating Tablets." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 530–38. https://doi.org/10.35629/4494-1003530538.

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Pharmaceutical technology has advanced significantly with the advent of Novel Drug Delivery Systems (NDDS), especially in the area of creating novel and creative formulations intended to increase therapeutic efficacy. In addition to improving the stability, bioavailability, and general safety of pharmaceutical substances, these advanced NDDS play a crucial role in protecting them against several types of degradation that may take place during storage or after administration. Among the wide variety of NDDS floating tablets, there are special benefits and mechanisms catered to particular medical

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Sha’at, Mousa, Lacramioara Ochiuz, Cristina Marcela Rusu, et al. "Experimental and Theoretical Design on the Development of Matrix Tablets with Multiple Drug Loadings Aimed at Optimizing Antidiabetic Medication." Pharmaceutics 16, no. 12 (2024): 1595. https://doi.org/10.3390/pharmaceutics16121595.

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Background: Diabetes is a growing global health crisis that requires effective therapeutic strategies to optimize treatment outcomes. This study aims to address this challenge by developing and characterizing extended-release polymeric matrix tablets containing metformin hydrochloride (M-HCl), a first-line treatment for type 2 diabetes, and honokiol (HNK), a bioactive compound with potential therapeutic benefits. The objective is to enhance glycemic control and overall therapeutic outcomes through an innovative dual-drug delivery system. Methods: The tablets were formulated using hydrophilic p

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Sipos, Bence, Márk Benei, Gábor Katona, and Ildikó Csóka. "Optimization and Characterization of Sodium Alginate Beads Providing Extended Release for Antidiabetic Drugs." Molecules 28, no. 19 (2023): 6980. http://dx.doi.org/10.3390/molecules28196980.

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The current research is aimed at investigating the relationship between the formulation components and conditions in the case of a binary drug delivery system, where antidiabetic drugs are co-formulated into polymeric micelles embedded in sodium alginate. Compared to chemical modifications of polymers with alginate, our development provides a simpler and scalable formulation process. Our results prove that a multi-level factorial design-based approach can ensure the development of a value-added polymeric micelle formulation with an average micelle size of 123.6 ± 3.1 nm and a monodisperse size

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Oliveira, Paulo Renato, Cassiana Mendes, Lilian Klein, Maximiliano da Silva Sangoi, Larissa Sakis Bernardi, and Marcos Antônio Segatto Silva. "Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets." BioMed Research International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/716736.

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The aim of this research was to develop a new hydrophilic matrix system containing norfloxacin (NFX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxypropylmethylcellulose or poly(ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at40±2°C and75±5% relative humidity), and the film-coating process is recommended to avoid NFX photodegradation. The disso

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S. Jat, Deepak, Swati G. Talele, Akshada A. Bakliwal, and Anil G. Jadhav. "DESIGN, DEVELOPMENT AND EVALUATION OF ALOGLIPTIN AND METFORMIN HYDROCHLORIDE BILAYER TABLET." Indian Drugs 59, no. 07 (2022): 74–76. http://dx.doi.org/10.53879/id.59.07.12280.

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The objective of the present work was to formulate and evaluate bilayer tablets of alogliptin and metformin HCl. Combining alogliptin with metformin HCL gives additional benefits in comparison with either drug alone and could be considered for patients whose quality of life is impaired by diabetes mellitus. The study was performed to design bilayer tablets of alogliptin immediate release layer and metformin HCl sustained release layer by wet granulation method. The immediate release layer comprised Crospovidone superdisintegrant and sustained release layer comprised HPMC K4M as rate release co

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Levitan, Bennett, Michael Markowitz, Ibrahim Turkoz, Dong-Jing Fu, Srihari Gopal, and Larry Alphs. "Benefit–risk assessment of paliperidone oral extended-release tablet versus monthly injectable for maintenance treatment of schizophrenia." International Clinical Psychopharmacology 31, no. 6 (2016): 315–22. http://dx.doi.org/10.1097/yic.0000000000000141.

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Bhadake, Mr Aniket V. "Review on Oral Osmotic Tablet." International Journal for Research in Applied Science and Engineering Technology 12, no. 11 (2024): 567–75. http://dx.doi.org/10.22214/ijraset.2024.65085.

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Traditional oral medication delivery methods provide the drug with an immediate release and an efficient concentration at the intended location. Such a dosage regimen could lead to unexpected, ever-changing plasma concentrations. As a result, numerous regulated medication delivery systems are created. Among these, osmotic drug delivery systems (ODDS) and pulsatile drug delivery systems (PDDS) are becoming more and more significant because they improve patient treatment efficacy and compliance by delivering the medicine at precise times based on the course and physiological requirements of the

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Muni, Raja Lakshmi K* Naseema Shaik Lavanya E. Venkata Rao Gadde. "Formulation And Evaluation of Sustained Release Matrix Tablets – A Review." Int. J. in Pharm. Sci. 1, no. 7 (2023): 170–81. https://doi.org/10.5281/zenodo.8114751.

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Oral drug delivery is still the finest and most popular method for administering pharmaceuticals via the internal route. Sustained release is also a good option for reducing adverse effect of drugs and boosting its therapeutic potency. The fundamental ideas of sustained drug delivery system optimise a variety of factors, such as a drugs pharmaceutical, pharmacokinetic and pharmacodynamic properties in order to increase therapeutic efficacy, minimise side effects and make disease cure simple. The major goal of this review is to provide comprehensive information about sustained release dose and

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K, Vijay, and Naruka PS. "Latest Advancements on Gastro Floating Bi-Layer Tablets of Metformin and Pioglitazone for the Treatment of Diabetes Mellitus." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1683–93. https://doi.org/10.25258/ijddt.14.4.76.

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The synergistic mode of action of pioglitazone hydrochloride (PG) and metformin hydrochloride (MH) has great potential for the treatment of type 2 diabetes mellitus. Because of their complementary modes of action, metformin hydrochloride (MH) and pioglitazone hydrochloride (PG) have great potential for the therapy of type 2 diabetes mellitus. Short half-life and the low absorption of metformin hydrochloride in lower gastrointestinal tract might restrict the action towards its expected therapeutic usefulness. This work aimed to create gastro-floating bilayer matrix tablets that would each conta

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K, Vijay, and Naruka PS. "Latest Advancements on Gastro Floating Bi-Layer Tablets of Metformin and Pioglitazone for the Treatment of Diabetes Mellitus." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1683–93. https://doi.org/10.25258/ijddt.14.4.77.

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The synergistic mode of action of pioglitazone hydrochloride (PG) and metformin hydrochloride (MH) has great potential for the treatment of type 2 diabetes mellitus. Because of their complementary modes of action, metformin hydrochloride (MH) and pioglitazone hydrochloride (PG) have great potential for the therapy of type 2 diabetes mellitus. Short half-life and the low absorption of metformin hydrochloride in lower gastrointestinal tract might restrict the action towards its expected therapeutic usefulness. This work aimed to create gastro-floating bilayer matrix tablets that would each conta

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Lin, Jing-Ting, Yi-Chan Chiang, Po-Hsien Li, and Po-Yuan Chiang. "Structural and Release Properties of Combined Curcumin Controlled-Release Tablets Formulated with Chitosan/Sodium Alginate/HPMC." Foods 13, no. 13 (2024): 2022. http://dx.doi.org/10.3390/foods13132022.

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Controlled-release tablets offer several benefits, such as controlled release, odor masking, ease of use, stability, extended shelf life, and reduced production costs. This study developed combined curcumin controlled-release tablets (CCCTs) to increase the bioavailability of curcumin with hydroxypropyl methylcellulose (HPMC), chitosan, and sodium alginate. The hardness of the CCCTs was 5.63–1.98 kgf, friability was 0.00–1.22%, and disintegration time was 0.00–401.25 min. Differential scanning calorimetry and Fourier-transform infrared spectroscopy indicated a high compatibility between the ex

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Nilesh, Mhaske Sudarshan Rashinkar. "Formulation And Evaluation Of Sustained Release Tablet Of Captoprilusing Cross-Linked Alginate." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 2054–64. https://doi.org/10.5281/zenodo.13117591.

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Over the past three decades, formulation technology has significantly advanced, particularly in drug delivery systems. Innovations include novel dosage forms and new uses for existing drugs, offering benefits like improved patient compliance, sustained drug concentration, reduced dosing frequency, targeted delivery, and minimized side effects. Transdermal drug delivery systems (TDDS) are key developments, allowing controlled, continuous medication administration through the skin, bypassing gastrointestinal degradation and hepatic first-pass metabolism, and enhancing bioavailability and patient

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