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1

Scott, Robert L. "Some comments on the Benesi-Hildebrand equation." Recueil des Travaux Chimiques des Pays-Bas 75, no. 7 (2010): 787–89. http://dx.doi.org/10.1002/recl.19560750711.

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2

Alam, F., S. B. Neogi, A. Das та ін. "Encapsulation of Biologically Potent Neurotransmitters into HP-β-CD Probed by Physicochemical Approach simultaneously Optimized by Computational Studies". Journal of Scientific Research 16, № 3 (2024): 783–801. http://dx.doi.org/10.3329/jsr.v16i3.69752.

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The inclusion complexes of the neurotransmitters, namely (±) epinephrine hydrochloride, dopamine hydrochloride, and tyramine hydrochloride in an aqueous medium, were studied physicochemically and spectroscopically. These rendered systems of drug delivery with the potential to ensure delivery to desired targets. The stoichiometry of the 1:1 ratio of host-guest binding was established using Job plots. Conductimetric studies gained an understanding of inclusion as a process. Furthermore, 1H NMR was used to characterize the inclusions, and the Benesi Hildebrand equation was applied to obtain the a
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3

Bhavya, P., R. M. Melavanki, D. Nagaraja, H. S. Geethanjali, R. A. Kusanur, and M. N. Manjunatha. "Binding interaction between 2-methoxy-5-fluoro phenyl boronic acid and sugars: Effect of structural change of sugars on binding affinity." Canadian Journal of Physics 94, no. 12 (2016): 1384–89. http://dx.doi.org/10.1139/cjp-2016-0484.

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The binding interaction of 2-methoxy-5-fluoro phenyl boronic acid with various sugars like dextrose, arabinose, xylose, sucrose, and lactose is investigated in aqueous medium at pH 7.4 using the fluorescence spectroscopic method. Fluorescence intensity is reduced upon addition of sugars. The change in the intensity is attributed to breaking of intramolecular hydrogen bonding and to the lesser stability of boronic ester. Data are analyzed using the Benesi–Hildebrand equation and Lineweaver–Burk equation. The estimated binding constants are greater in mono sugars arabinose and xylose. The fact t
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4

Shahi, Neelam, Kumar Shah, Prasad Yadav, and Ajaya Bhattarai. "The spectral study of azo dye and cationic surfactant interaction in ethanol-water mixture." Journal of the Serbian Chemical Society 86, no. 5 (2021): 483–94. http://dx.doi.org/10.2298/jsc201116020s.

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The interaction of the azo dye methyl red (MR) with dodecyl trimethyl ammonium bromide (DTAB) has been studied by the spectrometric methods through the azo-hydrazone tautomeric behaviour of MR for a series of the ethanol?water system (0.1, 0.2, 0.3 and 0.4 volume fractions of ethanol) at room temperature. The critical micelle concentration was determined using the conductometric technique with the increased ethanol volume, influenced by the solvent polarity and the architectural flexibility of methyl red. The azo form of methyl red brings the electrostatic interaction with the cationic surfact
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5

Grigoras, Anca, and Virgil Barboiu. "Influence of acceptor functionality on charge transfer interactions in mixtures of poly(9-vinylcarbazole) with nitroaromatic compounds." Open Chemistry 10, no. 2 (2012): 313–19. http://dx.doi.org/10.2478/s11532-011-0144-1.

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AbstractCharge transfer interactions in mixtures of poly(9-vinylcarbazole) with three nitro compounds (4,4′dinitrodibenzyl, ethyl 3,5-dinitrobenzoate and 2,2′,4,4′-tetranitrodibenzyl) were examined. GPC shows an increase of apparent polymer weight average molecular weight (MW) in mixtures compared with pure PVK. Electron acceptors show upfield 1H-NMR shifts for all mixtures. The equilibrium association constants (k) calculated from the Benesi-Hildebrand equation are 0.511, 1.371, and 1.868 L mol−1 for PVK blends with DNDB, DNBE and TNDB, respectively. Shifts of (−NO2) stretch vibrations in mix
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6

Longo, Luigia, Giuseppe Vasapollo, Anna Scardino, Rosaria Anna Picca, and Cosimino Malitesta. "Synthesis of a new substituted zinc phthalocyanine as functional monomer in the preparation of MIPs." Journal of Porphyrins and Phthalocyanines 10, no. 08 (2006): 1061–65. http://dx.doi.org/10.1142/s1088424606000417.

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A new zinc phthalocyanine peripherally substituted with methacrylic groups was synthesized to be employed as a functional monomer in the formation of molecularly imprinted polymers as nucleoside receptors. The binding affinity and selectivity of the synthesized phthalocyanine towards nucleosides were evaluated by UV-vis titration experiments in CH 2 Cl 2 at 298 K. The binding constant ( K a) and Gibbs free energy changes (-Δ G 0) were calculated according to the modified Benesi-Hildebrand equation. Binding experiments showed that K a of phthalocyanine with tri-O-acetyladenosine ( TOAA ) is 1.3
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7

Rahaman, Habibur, Niloy Roy, Aditi Roy, Samapika Ray та Mahendra Nath Roy. "Exploring Existence of Host-Guest Inclusion Complex of β-Cyclodextrin of a Biologically Active Compound with the Manifestation of Diverse Interactions". Emerging Science Journal 2, № 5 (2018): 251. http://dx.doi.org/10.28991/esj-2018-01149.

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The host–guest interaction of p-nitro benzaldehyde as guest β-Cyclodextrins have been investigated which have significant applications in the field of medicine such as controlled drug delivery. The 1H NMR study confirms the formation of inclusion complex while surface tension and conductivity studies support the formation inclusion complex with 1:1 stoichiometry. The stoichiometry of the inclusion complex was also supported with Job’s plot method by UV-Visible spectroscopy. FT-IR spectra and SEM study also support the inclusion process. Association constants of the inclusion complexes have bee
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8

Agatić, Zita Farkaš, Vesna Tepavčević, Gorana Puača, and Mihalj Poša. "Interaction of drug molecules with surfactants below (Benesi-Hildebrand equation) and above the critical micelle concentration (Kawamura equation)." International Journal of Pharmaceutics 665 (November 2024): 124675. http://dx.doi.org/10.1016/j.ijpharm.2024.124675.

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9

Qureshi, Pushkin M., Rishi K. Varshney та Sant Bahadur Singh. "Evaluation of ε for p-dinitrobenzene—aniline complexes by the Scott equation. Failure of the Benesi—Hildebrand equation". Spectrochimica Acta Part A: Molecular Spectroscopy 50, № 10 (1994): 1789–90. http://dx.doi.org/10.1016/0584-8539(94)80184-3.

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10

Jado, Demelash, Khalid Siraj, and Nathan Meka. "Electron Donor-Acceptor Interaction of 8-Hydroxyquinoline with Citric Acid in Different Solvents: Spectroscopic Studies." Journal of Applied Chemistry 2014 (August 17, 2014): 1–7. http://dx.doi.org/10.1155/2014/484361.

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Charge transfer complex formation between 8-hydroxyquinoline as the electron donor and citric acid as the electron acceptor has been studied spectrophotometrically in ethanol and methanol solvents at room temperature. Absorption band due to charge transfer complex formation was observed near 320 and 325 nm in ethanol and methanol, respectively. The stoichiometric ratio of the complex has been found 3 : 1 by using Job’s and conductometric titration methods. Benesi-Hildebrand equation has been applied to estimate the formation constant and molecular extinction coefficient. It was found that the
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11

Raj, G. Allen Gnana. "BINDING OF RUTHENIUM(II)POLYPYRIDYL COMPLEXES WITH POLYPHENOLS IN AQUEOUS MEDIUM." Green Chemistry & Technology Letters 1, no. 01 (2016): 77–81. http://dx.doi.org/10.18510/gctl.2015.1112.

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The binding of three Ru(II)-polypyridyl complexes with polyphenols (gallic acid and quercetin) have been studied in aqueous medium at pH 11 by means of absorption spectral technique. The absorption and emission maximum of this complexes are in the range of 451-457 nm and 612-626 nm respectively. The binding constant (Kb) for these reactions are determined from the Benesi-Hildebrand equation using absorption intensity data.The observed binding constant values are sensitive to the nature of the ligand and the structure of the gallic acid and quercetin. Quercetin binds strongly with Ru(II) comple
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12

Asok, K. Mukberjee, Pat Purnendu, and C. Mukherjee Dulal. "Spectrophotometric study of a charge transfer complex of 4-acetamidophenol with 2,3-dichloro-1,4-naphthoquinone in pure ethanol medium." Journal of Indian Chemical Society Vol. 85, Dec 2008 (2008): 1327–31. https://doi.org/10.5281/zenodo.5819761.

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Department of Chemistry, Burdwan University, Burdwan-713 104, West Bengal, India Metropoliton Institution, Burrabazar Branch, Kolkata-700 007, India coepartment of Chemistry, Heritage Institute of Technology, Anandapur, Kolkata-700 107, India <em>E-mail</em> : dcm_chem@yahoo.co.in <em>Manuscript received 19 November 2008, accepted 8 December 2008</em> 2,3-Dlchloro-1,4-naphthoquinone has been found to form a charge transfer complex with 4-acetamidophenol (paracetamol). The charge transfer band has been located and the formation constant value at different temperatures have been measured by usin
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13

Waranyoupalin, Ratanasuda, Sumpun Wongnawa, Malinee Wongnawa, Chaveng Pakawatchai, Pharkphoom Panichayupakaranant, and Panit Sherdshoopongse. "Studies on complex formation between curcumin and Hg(II) ion by spectrophotometric method: A new approach to overcome peak overlap." Open Chemistry 7, no. 3 (2009): 388–94. http://dx.doi.org/10.2478/s11532-009-0037-8.

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AbstractComplex formation between curcumin and Hg(II) ion MeOH/H2O (1: 1 v/v) was investigated and monitored by the spectrophotometric method. The absorption peak of unreacted curcumin which was close and overlapped with that of the complex, was removed by calculation using Microsoft Excel, thereby, allowing determination of the stoichiometry of the complex by the mole-ratio and the Job’s continuous variation methods. Both methods indicated that a 1:1 complex of curcumin and Hg(II) was formed in solution. The formation constant of the 1:1 Hg(II) complex was obtained from two methods, the equil
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14

Al-Wasidi, Asma S., Nawal M. Al-Jafshar, Amal M. Al-Anazi та ін. "Electron-transfer complexation of morpholine donor molecule with some π – acceptors: Synthesis and spectroscopic characterizations". Polish Journal of Chemical Technology 21, № 4 (2019): 82–88. http://dx.doi.org/10.2478/pjct-2019-0043.

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Abstract Morpholine is an interesting moiety that used widely in several organic syntheses. The intermolecular charge-transfer (CT) complexity associated between morpholine (Morp) donor with (monoiodobromide “IBr”, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone “DDQ”, 2,6-dichloroquinone-4-chloroimide “DCQ” and 2,6-dibromoquinone-4-chloroimide “DBQ”) π–acceptors have been spectrophotometrically investigated in CHCl3 and/or MeOH solvents. The structures of the intermolecular charge-transfer (CT) were elucidated by spectroscopic methods like, infrared spectroscopy. Also, different analyses techniques
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15

Abbu, Venugopal, Venkatesh Nampally, Ramakanth Pagadala, Sambhani Naga Gayatri, Thirupathi Damera, and T. Parthasarathy. "Charge Transfer Complexes of 1-Cyclohexylpiperazine as Donor with 2,3-Dichloro-5,6-dicyano-p-benzoquinone and 2,3,5,6-Tetra chloro-p-benzoquinone as Acceptors: A Comparative Studies of Spectroscopic, Thermodynamic and DFT Analysis." Asian Journal of Chemistry 36, no. 6 (2024): 1251–64. http://dx.doi.org/10.14233/ajchem.2024.31296.

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Novel 1-cyclohexylpiperazine charge transfer compounds, acting as donors, were investigated in conjunction with the π-acceptors 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 2,3,5,6-tetrachloro-p-benzoquinone (CHL) through spectrophotometric analysis at room temperature in acetonitrile. The Benesi-Hildebrand equation was applied to determine the molar extinction coefficient (ε) and stability constant (KCT) for both charge transfer (CT) complexes, each exhibiting a 1:1 molar composition. The infrared (IR) spectroscopy confirmed the presence of CT complexes and these complexes were further e
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16

S., Muzaffar Ali Andrabi. "Evaluation of the association constants of molecular complexes by electronic and NMR spectroscopy - First evidence for association constants measured by NMR spectroscopy being independent of the methods used." Journal of Indian Chemical Society Vol. 86, Aug 2009 (2009): 826–31. https://doi.org/10.5281/zenodo.5814872.

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University Science Instrumentation Centre, University of Kashmir, Srinagar-190 006, Jammu &amp; Kashmir, India <em>E-mail</em> : smaal@rediffmail.com <em>Manuscript received 2 September 2008. revised 28 January 2009, accepted 19 March 2009</em> Modified Benesi-Hildebrand and Hanna-Ashbaugh equations have been used for the evaluation of association constants of the charge-transfer complexes by electronic spectroscopy and NMR spectroscopy, respectively. Association constants of charge-transfer complexes of aniline with various dinitrobenzenes have been calculated by electronic spectroscopy using
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17

Arshad, Nasima, Naghmana Rashid, Sajida Absar, Muhammad Abbasi, Samreen Saleem, and Bushra Mirza. "UV-absorption studies of interaction of karanjin and karanjachromene with ds. DNA: Evaluation of binding and antioxidant activity." Open Chemistry 11, no. 12 (2013): 2040–47. http://dx.doi.org/10.2478/s11532-013-0327-z.

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AbstractTwo flavonoids, karanjin (Kj) and karanjachromene (Kc) have been investigated spectrophotometrically for their mode of interactions with double stranded (ds)-DNA at blood (7.4) and stomach (4.7) pH and at human body temperature (37°C). Benesi-Hildebrand equation was used to evaluate the binding constants, K b . Binding constants at both pH values and at body temperature showed stronger binding of both the flavonoids and formation of 1:1 flavonoid-DNA complex via intercalative mode. However, K b values for karanjin were evaluated to be comparatively greater than karanjachromene at both
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18

Arunapriya, L., and N. Venkatesh. "Synthesis of Charge Transfer Complexation between 2,5-Dihydroxy-p-benzoquinone and 2-Amino Aniline; Spectral Characterization and DFT Analysis." Asian Journal of Chemistry 37, no. 2 (2025): 284–90. https://doi.org/10.14233/ajchem.2025.32990.

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A charge transfer (CT) complex was synthesized using electron donor 2-amino aniline (AA) and electron acceptor 2,5-dihydroxy benzoquinone (DHBQ) in an acetonitrile medium. The charge transfer complex stoichiometry is 1:1. The Benesi-Hildebrand equation was used to determine the molar absorptivity (εCT), association constant (KCT) and other physical constants. The synthesized solid CT-complex was analyzed by 1H NMR and FT-IR spectroscopic methods. DFT study of the CT complex (gas phase) at the basis set B3LYP/6-31++G also gave similar results of the experimental work. Mulliken atomic charges an
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19

Udrescu, Lucreția, Laura Sbârcea, Adriana Fuliaș та ін. "Physicochemical Analysis and Molecular Modeling of the Fosinoprilβ-Cyclodextrin Inclusion Complex". Journal of Spectroscopy 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/748468.

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This research investigates the interaction between fosinopril sodium (FOS) and beta-cyclodextrin (β-CD) in aqueous solution and in solid state, in order to prove the formation of an inclusion complex between the two components. The stoichiometry of the inclusion complex was found as 1 : 1 by employing continuous variation method in UV. The formation constant was calculated as 278.93 M−1using Benesi-Hildebrand equation. The kneaded product (KP) and the physical mixture (PM) were further experimentally examined, using FTIR, powder X-ray diffractometry, and thermal analysis. The results confirm t
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20

Mostafa, Gamal A. E., Ahmed Bakheit, Najla AlMasoud, and Haitham AlRabiah. "Charge Transfer Complexes of Ketotifen with 2,3-Dichloro-5,6-dicyano-p-benzoquinone and 7,7,8,8-Tetracyanoquodimethane: Spectroscopic Characterization Studies." Molecules 26, no. 7 (2021): 2039. http://dx.doi.org/10.3390/molecules26072039.

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The reactions of ketotifen fumarate (KT) with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as π acceptors to form charge transfer (CT) complexes were evaluated in this study. Experimental and theoretical approaches, including density function theory (DFT), were used to obtain the comprehensive, reliable, and accurate structure elucidation of the developed CT complexes. The CT complexes (KT-DDQ and KT-TCNQ) were monitored at 485 and 843 nm, respectively, and the calibration curve ranged from 10 to 100 ppm for KT-DDQ and 2.5 to 40 ppm for KT-TCNQ. The
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21

Kaushal, Raj, Sheetal Thakur, and Kiran Nehra. "ct-DNA Binding and Antibacterial Activity of Octahedral Titanium (IV) Heteroleptic (Benzoylacetone and Hydroxamic Acids) Complexes." International Journal of Medicinal Chemistry 2016 (March 16, 2016): 1–11. http://dx.doi.org/10.1155/2016/2361214.

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Five structurally related titanium (IV) heteroleptic complexes, [TiCl2(bzac)(L1–4)] and [TiCl3(bzac)(HL5)]; bzac = benzoylacetonate; L1–5 = benzohydroximate (L1), salicylhydroximate (L2), acetohydroximate (L3), hydroxyurea (L4), and N-benzoyl-N-phenyl hydroxylamine (L5), were used for the assessment of their antibacterial activities against ten pathogenic bacterial strains. The titanium (IV) complexes (1–5) demonstrated significant level of antibacterial properties as measured using agar well diffusion method. UV-Vis absorption spectroscopic technique was applied, to get a better insight into
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22

Gorza, Filipe D. S., Graciela C. Pedro, Tarquin F. Trescher, Romário J. da Silva, Josmary R. Silva, and Nara C. de Souza. "Morphological Analysis and Interaction of Chlorophyll and BSA." BioMed Research International 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/872701.

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Interactions between proteins and drugs, which can lead to formation of stable drug-protein complexes, have important implications on several processes related to human health. These interactions can affect, for instance, free concentration, biological activity, and metabolism of the drugs in the blood stream. Here, we report on the UV-Visible spectroscopic investigation on the interaction of bovine serum albumin (BSA) with chlorophyll (Chl) in aqueous solution under physiological conditions. Binding constants at different temperatures—obtained by using the Benesi-Hildebrand equation—were foun
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23

Wei, Yuhan, Lei Xu, Shengjiao He, et al. "Novel benzimidazole-based conjugated polyelectrolytes: synthesis, solution photophysics and fluorescent sensing of metal ions." e-Polymers 20, no. 1 (2020): 16–31. http://dx.doi.org/10.1515/epoly-2020-0003.

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AbstractTwo benzimidazole-based conjugated polyelectrolytes (+)-PPBIPV and (-)-PPBIPV which have opposite charges on their side chains were synthesized via Heck coupling reaction and characterized by 1H-NMR, UV-vis and PL spectroscopy. These two polyelectrolytes are both consisted of benzimidazole derivatives and phenylenevinylene units. The absorption and emission spectra reveal that the polymers both have solvent-dependency and concentration-dependency, and they exhibit aggregation effect in aqueous solution. In the respect of ion detection, the aqueous solution of (+)-PPBIPV has excellent s
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24

Lachowicz, Dorota, Przemyslaw Mielczarek, Roma Wirecka, et al. "Nanohydrogels Based on Self-Assembly of Cationic Pullulan and Anionic Dextran Derivatives for Efficient Delivery of Piroxicam." Pharmaceutics 11, no. 12 (2019): 622. http://dx.doi.org/10.3390/pharmaceutics11120622.

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A cationic derivative of pullulan was obtained by grafting reaction and used together with dextran sulfate to form polysaccharide-based nanohydrogel cross-linked via electrostatic interactions between polyions. Due to the polycation-polyanion interactions nanohydrogel particles were formed instantly and spontaneously in water. The nanoparticles were colloidally stable and their size and surface charge could be controlled by the polycation/polyanion ratio. The morphology of the obtained particles was visualized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and at
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25

P., Jagadeesh U. Srikanth M. M. Eswarudu* P. Srinivasa Babu Sk. Aneesh P.S.H. R. Khan S. Sai Pooja K. Naga Rani. "NEW VALIDATED EXTRACTIVE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF RUFINAMIDE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 06 (2019): 11798–805. https://doi.org/10.5281/zenodo.3244150.

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<em>A simple, precise, selective and affordable spectrphotometric method has been developed for the determination of Rufinamide in its bulk and pharmaceutical dosage form. The method was based on ion-pair complex formation between the drug and anionic dye i.e. Bromothymol blue in acidic medium (pH 2.0-4.0). The coloured complex formed was quantitatively extracted into chloroform and measured wavelength at 416.5 nm. Beer&rsquo;s law was obeyed in the concentration range of 10-60&micro;g/ml with correlation coefficient (n=6) &ge; 0.997. The stoichiometry of the complexes formed between drug and
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26

Аkimova, А. V., G. N. Rychkov, М. А. Grin, et al. "Interaction with Serum Albumin As a Factor of the Photodynamic Efficacy of Novel Bacteriopurpurinimide Derivatives." Acta Naturae 7, no. 1 (2015): 109–16. http://dx.doi.org/10.32607/20758251-2015-7-1-109-116.

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Optimization of the chemical structure of antitumor photosensitizers (PSs) is aimed at increasing their affinity to a transport protein, albumin and irreversible light-induced tumor cell damage. Bacteriopurpurinimide derivatives are promising PSs thanks to their ability to absorb light in the near infrared spectral region. Using spectrophotometry, we show that two new bacteriopurpurinimide derivatives with different substituents at the N atoms of the imide exocycle and the pyrrole ring A are capable of forming non-covalent complexes with human serum albumin (HSA). The association constant (cal
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27

Sundarpal, V., J. Srinu, G. Sailaja, et al. "Charge Transfer Interaction Dynamics between 2-Methyl-8-hydroxyquinoline and 2,4-Dinitrophenol: Synthesis, Spectroscopic Characterization, DNA Binding and DFT Studies." Asian Journal of Chemistry 36, no. 11 (2024): 2583–92. http://dx.doi.org/10.14233/ajchem.2024.32582.

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A novel charge transfer (CT) complex was formed by combining the electron-acceptor 2,4-dinitrophenol (DNP) with the electron-donor 2-methyl-8-hydroxyquinoline (MHQ). The complex obtained was further characterized using both experimental and theoretical methods. The Benesi-Hildebrand equation can be utilized to determine various spectroscopic physical measurements such as the molar absorptivity (εCT) and formation constant (KCT). The CT complex has a stoichiometry of 1:1. Multiple spectroscopic methods were employed to investigate the resultant solid compound. The existence of charge and proton
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28

Göktürk, Sinem, Elif Çalışkan, R. Yeşim Talman, and Umran Var. "A Study on Solubilization of Poorly Soluble Drugs by Cyclodextrins and Micelles: Complexation and Binding Characteristics of Sulfamethoxazole and Trimethoprim." Scientific World Journal 2012 (2012): 1–12. http://dx.doi.org/10.1100/2012/718791.

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The present study is focused on the characterization of solubilization of poorly soluble drugs, that is, sulfamethoxazole (SMX) and trimethoprim (TMP) by cyclodextrins (α-, β-, and γ-CDs) and anionic surfactant sodium dodecyl sulfate (SDS). The phase solubility diagrams drawn from UV spectral measurements are of theALtype and indicate an enhancement of SMX and TMP solubility in the presence of CDs. Complex formation tendency of TMP with CDs followed the order: γ-CD &gt; β-CD &gt; α-C. However, the complex formation constant values, for SMX-CD system yielded the different affinity and follow th
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29

Rahman, A. F. M. Motiur, Ahmed H. Bakheit, Shofiur Rahman, Gamal A. E. Mostafa, and Haitham Alrabiah. "Procainamide Charge Transfer Complexes with Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone: Experimental and Theoretical Study." Processes 11, no. 3 (2023): 711. http://dx.doi.org/10.3390/pr11030711.

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The formation of charge transfer (CT) complexes between bioactive molecules and/or organic molecules is an important aspect in order to understand ‘molecule-receptor’ interactions. Here, we have synthesized two new CT complexes, procainamide-chloranilic acid (PA-ChA) and procainamide-2,3-dichloro-5,6-dicyano-1,4-benzoquinone (PA-DDQ), from electron donor procainamide (PA), electron acceptor chloranilic acid (ChA), and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The structures of these two CT complexes were elucidated/characterized using FTIR, NMR, and many other spectroscopic methods. A s
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30

El-Shafie, Ahmed S., Aseel Yousef, and Marwa El-Azazy. "Application of Plackett–Burman Design for Spectrochemical Determination of the Last-Resort Antibiotic, Tigecycline, in Pure Form and in Pharmaceuticals: Investigation of Thermodynamics and Kinetics." Pharmaceuticals 15, no. 7 (2022): 888. http://dx.doi.org/10.3390/ph15070888.

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Tigecycline (TIGC) reacts with 7,7,8,8-tetracyanoquinodimethane (TCNQ) to form a bright green charge transfer complex (CTC). The spectrum of the CTC showed multiple charge transfer bands with a major peak at 843 nm. The Plackett–Burman design (PBD) was used to investigate the process variables with the objective being set to obtaining the maximum absorbance and thus sensitivity. Four variables, three of which were numerical (temperature—Temp; reagent volume—RV; reaction time—RT) and one non-numerical (diluting solvent—DS), were studied. The maximum absorbance was achieved using a factorial ble
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31

Manigandan, Subramani, Athianna Muthusamy, Raju Nandhakumar, Charles Immanuel David, and Siddeswaran Anand. "Synthesis, characterization, theoretical investigations and fluorescent sensing behavior of oligomeric azine-based Fe3+Chemosensors." High Performance Polymers 34, no. 3 (2021): 321–36. http://dx.doi.org/10.1177/09540083211055675.

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Three azine oligomeric esters were synthesized, characterized by IR, UV, 1H, 13C{1H} and GPC technique, and applied to chemosensor application. The sensitivity response of the oligomers towards the metal ion was evaluated for a metal ion series. The results have shown selective and sensitive “turn off” fluorescence response towards Fe3+ ion in DMF/H2O (1:1, pH: 7.4, fluorophore: 5 μM) solution. The binding stoichiometry and binding constant of the fluorophores were calculated using the Stern–Volmer equation and Benesi–Hildebrand plots, respectively. The quenching of fluorophores on the additio
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32

Yuan, Haokun, Ran Zhang, Kai Hu, and Ruiqin Fang. "Proton-transfer salts of diphenylphosphinic acid with substituted 2-aminopyridine: crystal structure, spectroscopic and DFT studies." Acta Crystallographica Section C Structural Chemistry 79, no. 5 (2023): 193–203. http://dx.doi.org/10.1107/s2053229623003388.

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Three proton-transfer salts of diphenylphosphinic acid (DPPA) with 2-amino-5-(X)-pyridine (AMPY, X = Cl, CN or CH3), namely, 2-amino-5-chloropyridinium diphenylphosphinate, C5H6ClN2 +·C12H10O2P− (1, X = Cl), 2-amino-5-cyanopyridinium diphenylphosphinate, C6H6N3 +·C12H10O2P− (2, X = CN), and 2-amino-5-methylpyridinium diphenylphosphinate, C6H9N2 +·C12H10O2P− (3, X = CH3), have been synthesized and characterized by FT–IR and 1H NMR spectroscopy, and X-ray crystallography. The crystal structures of compounds 1–3 were determined in the space group P\overline{1} for 1 and 2, and C2/c for 3. All thr
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33

Alghanmi, Reem M., Maram T. Basha, Ahlam I. Al-Sulami, Saied M. Soliman, and Laila H. Abdel-Rahman. "A New Proton Transfer Complex Between 3,4-Diaminopyridine Drug and 2,6-Dichloro-4-nitrophenol: Synthesis, Spectroscopic Characterization, DFT Studies, DNA Binding Analysis, and Antitumor Activity." Molecules 29, no. 21 (2024): 5120. http://dx.doi.org/10.3390/molecules29215120.

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The proton transfer (PT) complexation reaction between 3,4-diaminopyridine (3,4-DAP), an important drug, and 2,6-dichloro-4-nitrphenole (DCNP) was investigated experimentally and theoretically. The experimental results indicated a chemical reaction occurred because of a hydrogen bonding, followed by proton transfer from the DCNP to the 3,4-DAP in different polar media. The Benesi–Hildebrand equation was used to estimate the formation constant (Kf), molar absorptivity (εPT), and other physical parameters. The formed PT complex was characterized using FTIR, 1H, and 13C NMR spectra. In addition,
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34

Verma, Awadhesh Kumar, and Z. A. Ansari. "Fluorescent ZnO Quantum Dot Probe to Study Glucose–Glucose Oxidase Interaction via Fluorescence Resonance Energy Transfer." Sensor Letters 18, no. 5 (2020): 351–65. http://dx.doi.org/10.1166/sl.2020.4232.

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In this work, emphasis is to utilize FRET method to analyze GOx and glucose interaction using fluorescent ZnO QDs as the probes. Fluorescent ZnO and ZnOext QDs were synthesized using sol– gel technique and green synthesis method as donor and acceptor nanoprobes. Structural, optical and morphological characterization of QDS were carried out using UV-visible absorption, fluorescence, FTIR, XRD and field emission scanning electron microscopy. Band gap estimated from Tauc plot is 3.49 and 3.35 eV for ZnO and ZnOext QDs and XRD reveal Wurtzite structure of grown crystals. Systematic absorption stud
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35

Mostafa, Gamal A. E., Tarek A. Yousef, Samir T. Gaballah, et al. "Quinine Charge Transfer Complexes with 2,3-Dichloro-5,6-Dicyano-Benzoquinone and 7,7,8,8-Tetracyanoquinodimethane: Spectroscopic Characterization and Theoretical Study." Applied Sciences 12, no. 3 (2022): 978. http://dx.doi.org/10.3390/app12030978.

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The molecular charge transfer reactions of quinine (Q) with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as a π-acceptor to form charge transfer (CT) complexes have been studied. The CT complexes were characterized by infrared spectra, NMR, mass spectrometry, conductometry and spectrometry. The Q-DDQ and Q-TCNQ charge transfer complexes were monitored at 480 and 843 nm, respectively. The results confirm the formation of CT complexes. The molar ratio of Q:DDQ and Q: TCNQ assessed using Job’s method was 1:1, which agrees with the results obtained by t
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36

Tao, Jisheng, Fang Guo, Yue Sun, Xiaoxia Sun, and Yu Hu. "Self-Assembled Nanotubes Based on Chiral H8-BINOL Modified with 1,2,3-Triazole to Recognize Bi3+ Efficiently by ICT Mechanism." Micromachines 15, no. 1 (2024): 163. http://dx.doi.org/10.3390/mi15010163.

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A novel fluorescent “off” probe R-β-D-1 containing a 1,2,3-triazole moiety was obtained by the Click reaction with azidoglucose using H8-BINOL as a substrate, and the structure was characterized by 1H NMR and 13C NMR and ESI-MS analysis. The fluorescence properties of R-β-D-1 in methanol were investigated, and it was found that R-β-D-1 could be selectively fluorescently quenched by Bi3+ in the recognition of 19 metal ions and basic cations. The recognition process of Bi3+ by R-β-D-1 was also investigated by fluorescence spectroscopy, SEM, AFM, etc. The complex pattern of R-β-D-1 with Bi3+ was
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37

Rizzi, Vito, Sergio Matera, Paola Semeraro, Paola Fini, and Pinalysa Cosma. "Interactions between 4-thiothymidine and water-soluble cyclodextrins: Evidence for supramolecular structures in aqueous solutions." Beilstein Journal of Organic Chemistry 12 (March 21, 2016): 549–63. http://dx.doi.org/10.3762/bjoc.12.54.

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Since several years the inclusion of organic compounds (guests) within the hydrophobic cavity (host) of cyclodextrins (CDs) has been the subject of many investigations. Interestingly, the formation of inclusion complexes could affect the properties of the guest molecules and, for example, the influence of the delivery system can be a method to improve/change the photochemical behavior of the guest. In particular, very recent studies have shown the protective role of CDs preventing the degradation of the encapsulated guest. Starting from this consideration, in this work, only the structure and
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38

Green, Michael D., Gabor Patonay, Thilivhali Ndou, and Isiah M. Warner. "Spectroscopic Effects of Organized Media on a Cyanine Dye/Phenanthrene Derivative." Applied Spectroscopy 46, no. 11 (1992): 1724–28. http://dx.doi.org/10.1366/0003702924926862.

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Absorbance and fluorescence characteristics of a cyanine dye/phenanthrene derivative are studied in the presence of β- and γ-cyclodextrin, Brij 35, cetyltrimethyl ammonium bromide (CTAB), and sodium dodecyl sulfate (SDS). The apparent association constant for the dye cyclodextrin complex is estimated with the use of Benesi-Hildebrand equations. Absorbance measurements are used to estimate the dimerization constant of the dye in aqueous solution.
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39

Demirhan, Hulya, Mustafa Arslan, Mustafa Zengin та Mustafa Kucukislamoglu. "Investigation of Charge Transfer Complexes Formed between Mirtazapine and Someπ-Acceptors". Journal of Spectroscopy 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/875953.

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Charge transfer complexes (CTC) of mirtazapine with tetracyanoethylene (TCNE), 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), and tetracyanoquinodimethane (TCNQ) have been studied spectrophotometrically in dichloromethane at room temperature. The stoichiometries of the complexes were found to be 1 : 1 ratio by the Job Method between mirtazapine and the acceptors. The equilibrium constants and thermodynamic parameters of the complexes were determined by the Benesi-Hildebrand and Van't Hoff equations. Mirtazapine in pure and dosage form was applied in this study. The results indicate that the fo
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40

Hadi, Hind. "Spectrophotometric Determination of Clonazepam in Pure and Dosage forms using Charge Transfer Reaction." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 24, no. 1 (2017): 25–32. http://dx.doi.org/10.31351/vol24iss1pp25-32.

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A rapid, sensitive and without extraction spectrophotometric method for determination of clonazepam (CLO) in pure and pharmaceutical dosage forms has been described. The proposed method was simply depended on charge transfer reaction between reduced CLO (n-donor) and metol (N-methyl-p-aminophenol sulfate) as a chromogenic reagent (π- acceptor). The reduced drug, with zinc and concentrated hydrochloric acid, produced a purple colored soluble charge-transfer complex with metol in the presence of sodium metaperiodate in neutral medium, which has been measured at λmax 532 nm. All the variables w
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41

D., B. Patil, D. Patil V., R. Pujari S., and B. Deshmukh M. "Spectroscopic studies of molecular interactions involving aniline and substituted aniline donors and chloranil as an electron acceptor in a binary solvent mixtures." Journal of Indian Chemical Society Vol. 82, Jun 2005 (2005): 530–33. https://doi.org/10.5281/zenodo.5830600.

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Chemistry Department, Vivekanand College, Kolhapur-416 003, India TKIET, Warananagar, Dist. Kolhapur, India Department of Chemistry, Shivaji University, Kolhapur-416 004, India <em>Manuscript received 13 January 2004, revised 1 February 2005, accepted 9 March 2005</em> Charge-transfer complexes of chloranil acceptor with aniline and substituted anilines as donors were studied in binary solvent mixtures of different composition of benzene and dichloromethane (by volume) at room temperature. The stoichiometry of the complexes was established to be 1 : 1. For this purpose, optical data were subje
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42

"Study of A Tridentate Schiff-Base as A Highly Selective Fluorescent Sensor for Detection of Copper and Chromium Ions." IUG Journal of Natural Studies 2, no. 30 (2022). http://dx.doi.org/10.33976/iugns.30.2/2022/3.

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A simple and easily synthesized fluorescent sensor, Schiff base sensor (SBS), produced by condensation reaction of equal amounts of anthranilic acid and salicyladehyde. It was synthesized and characterized systemically. Both UV-vis and fluorescence spectroscopic studies indicated that the SBS sensor showed good selectivity toward the studied ions: Na+, K+, Cu2+, Co2+, Fe3+ , Al3+ and Cr3+. Whereas, chromium (III) and copper (II) exhibited the largest fluorescence enhancement over the other investigated ions. Chelation-enhanced fluorescence were shown upon the interaction of SBS sensor with som
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43

Vellaisamy, Kannan, Esakkimuthu Shanmugasundram, Vigneshkumar Ganesan, Saivaraj Senguttuvan та Stalin Thambusamy. "Synthesis, Characterization, Spectroscopic, and Electrochemical Investigation of Inclusion Complex of Ethyl Cinnamate with γ‐Cyclodextrin for Antibacterial Studies". ChemistrySelect 9, № 36 (2024). http://dx.doi.org/10.1002/slct.202402922.

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AbstractWe synthesized cinnamic acid derivatives of ethyl cinnamate (EC) and analyzed the resulting products using 1H‐NMR and FTIR spectroscopy. The formation of the confirmed EC and γ‐Cyclodextrin inclusion complex is investigated through UV–vis and fluorescence spectroscopy. Cyclic voltammetry techniques are employed to analyze the formation of the inclusion complex. By using Job's plot, the stoichiometric ratio of the inclusion complex is found to be 1:1, and the binding constant (K) is calculated through the Benesi‐Hildebrand plot. Furthermore, we calculated the thermodynamic parameters (Δ
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44

Jaafar, Farah Saadoon, and Mahasin F. Alias. "Application of Benesi–Hildebrand and Tauc approaches of new synthesized Schiff bases interacted with two types of electron acceptors modules." Journal of Umm Al-Qura University for Applied Sciences, June 3, 2025. https://doi.org/10.1007/s43994-025-00243-4.

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Abstract This study has three parts, the first one is the synthesis of a novel Schiff bases by the condensation of guanine or 9-[{2-hydroxyethoxy}methyl]-9H-guanine with variety aldehydes to yield four different bases as follows: (E)-2-((4-nitrobenzylidene)amino)-1,9-dihydro-6H-purin-6-one (S1), (E)-2-((4-methoxybenzylidene)amino)-1,9-dihydro-6H-purin-6-one (S2), (E)-2-((2-hydroxybenzylidene) amino)-9-((2-hydroxy ethoxy)methyl)-1,9-dihydro-6H-purin-6-one (S3), and (E)-2-(((9-((2-hydroxy ethoxy)methyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)imino)methyl)benzoic acid (S4). Then, spectroscopic analyses
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45

Kharpan, Bandashisha, Jagritima Chetia, Hunshisha Pyngrope, et al. "A Highly Efficient and Selective Glycine Based Schiff Base Fluorescent Probe for Dual Sensing of Zn(II) and Cu(II) and its Antibacterial Activity and BSA Interaction Studies." ChemistrySelect 9, no. 14 (2024). http://dx.doi.org/10.1002/slct.202400167.

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AbstractA mesogenic glycine based Schiff base compound of the type, (E)‐methyl 2‐((2‐hydroxy‐4‐(tetradecyloxy)benzylidene)amino)acetate (HL) has been successfully synthesized and characterized using analytical and spectroscopic techniques. The Schiff base compound was evaluated for chemosensor activity towards different metal ions using fluorescence spectroscopy. The experiment reveals highly efficient and selective “turn‐on” and “turn‐off” responses of the fluorescence intensity towards zinc(II) and copper(II), respectively, in presence of other metal ions. The binding constant and the stoich
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46

Magdy, Galal, Moataz A. Shaldam, Fathalla Belal, and Heba Elmansi. "Multi-spectroscopic, thermodynamic, and molecular docking/dynamic approaches for characterization of the binding interaction between calf thymus DNA and palbociclib." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-19015-9.

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AbstractStudying the binding interaction between biological macromolecules and small molecules has formed the core of different research aspects. The interaction of palbociclib with calf thymus DNA at simulated physiological conditions (pH 7.4) was studied using different approaches, including spectrophotometry, spectrofluorimetry, FT-IR spectroscopy, viscosity measurements, ionic strength measurements, thermodynamic, molecular dynamic simulation, and docking studies. The obtained findings showed an apparent binding interaction between palbociclib and calf thymus DNA. Groove binding mode was c
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47

S., NIRANJANI, and VENKATACHALAM K. "SPECTROPHOTOMETRIC DETERMINATION OF ATORVASTATIN CALCIUM AND PITAVASTATIN CALCIUM THROUGH ION-PAIR COMPLEX FORMATION USING ACID DYES IN PHARMACEUTICAL FORMULATIONS AND HUMAN URINE SAMPLES." International Journal of Applied Pharmaceutics, October 5, 2019, 171–80. http://dx.doi.org/10.22159/ijap.2019v11i6.35246.

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Objective: The main objective was to develop simple, cost-effective, rapid and selective spectrophotometric methods for the determination of atorvastatin calcium and pitavastatin calcium in pure and pharmaceutical formulations using acid dyes like bromothymol blue, bromocresol purple and bromocresol green and also in human urine samples.&#x0D; Methods: The developed methods were based on the formation of ion-pair complexes between statin drugs and acid dyes after studying the optimization conditions. The association constants of the developed ion-pair complexes were evaluated using Benesi–Hild
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48

Rajendran, Praveena, Parvathavarthini Murugaperumal, Sengottuvelan Nallathambi, Franc Perdih, Siva Ayyanar, and Selvaraju Chellappan. "Performance of 4,5‐diphenyl‐1H‐imidazole derived highly selective ‘Turn‐Off’ fluorescent chemosensor for iron(III) ions detection and biological applications." Luminescence 39, no. 3 (2024). http://dx.doi.org/10.1002/bio.4694.

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AbstractTwo fluorescent chemosensors, denoted as chemosensor 1 and chemosensor 2, were synthesized and subjected to comprehensive characterization using various techniques. The characterization techniques employed were Fourier‐transform infrared (FTIR), proton (1H)‐ and carbon‐13 (13C)‐nuclear magnetic resonance (NMR) spectroscopy, electrospray ionization (ESI) mass spectrometry, and single crystal X‐ray diffraction analysis. Chemosensor 1 is composed of a 1H‐imidazole core with specific substituents, including a 4‐(2‐(4,5‐c‐2‐yl)naphthalene‐3‐yloxy)butoxy)naphthalene‐1‐yl moiety. However, che
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49

Subbaiah, Maniyammai, Kiran K. Mandrekar, Abbas Khaja Raees Ahmed, Aziz Kalilur Rahiman, Kesavan Muthu, and Senthil A. Gurusamy Thangavelu. "Hybrid Inorganic–Organic Phosphorus(V) Dihydrazone as Colorimetric and Fluorometric Probe for the Detection of Fe2+ and Zn2+ Cations: Synthesis, Physicochemical, Photophysical, NMR, Cyclic Voltammetry, and DFT Studies." Applied Organometallic Chemistry 39, no. 4 (2025). https://doi.org/10.1002/aoc.70093.

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ABSTRACTA new hybrid inorganic–organic probe, phenylphosphonothioic salicylic dihydrazone (PPSD), was designed, synthesized, and characterized as Schiff base via simple condensation reaction using two units of salicylaldehyde with phenylphosphonothioic dihydrazide (PPDH). In the colorimetric studies, PPSD in methanol medium responded as probe to detect cations iron (Fe2+) and zinc (Zn2+). During attempts to venture PPSD as probe with series of cations (Fe2+, Co2+, Ni2+, Ca2+, Li+, Zn2+, Cu2+, Na+, Al3+, and Ce2+), detection of cations was observed specifically with Zn2+ and Fe2+ cations. Herei
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50

H. Alwaan, Liqaa. "A nano-spectral study of charge transfer complexes to alizarin dye with electronic acceptors (TiO2)." Experimental and Theoretical NANOTECHNOLOGY, January 15, 2020, 37–47. http://dx.doi.org/10.56053/4.1.37.

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The research involves the preparation of the nano-accepters, titanium dioxide (TiO2). It is diagnosed by different techniques such as IR, AFM, SEM, XRD and EDX, which illustrated the topographic features and features of the nano-crystalline prepared in terms of crystalline level, size of minute, pore shape, and elements analysis and et al. The study also includes a spectroscopic study of the transfer complexes of the charge using nano-TiO2 as the accepter’s electron with the alizarin dye extracted as donor electrons using absolute ethanol as a solvent. The Bensi-Hildebrand equation is applied
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