Log in

Relevant bibliographies by topics / Benzal Derivatives / Journal articles

To see the other types of publications on this topic, follow the link: Benzal Derivatives.

Journal articles on the topic 'Benzal Derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Benzal Derivatives.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Dekate, Shital M., Kishor M. Hatzade, and Ajay M. Ghatole. "A Facile Synthesis of Thiazole Derivatives bearing Imidazole Moiety, Schiff Bases and their O-Glucosides." Asian Journal of Chemistry 35, no. 1 (2022): 29–38. http://dx.doi.org/10.14233/ajchem.2023.24049.

Full text

Abstract:

A unique approach for the synthesis of new thiazole O-glycosides is presented in this work. 2-Amino-4-hydroxy-phenyl-1,3-thiazole-5-carboxaldehyde (3a) was reacted with phenyl glyoxal and benzil to form 4-(4-hydroxy-phenyl)-5-(4-phenyl-1H-imidazol-2-yl)-thiazol-2-amine (4a) and 4-(4-hydroxy-phenyl)-5-(4,5-diphenyl-1H-imidazol-2-yl)-thiazol-2-amine (4b), respectively. A series of substituted Schiff bases of 4a and 4b were synthesized reacting with various aryl aldehyde to form 2-(imino substituted benzal)-4-(4-hydroxy-phenyl)-5-(4-phenyl-1H-imidazol-2-yl)-thiazoles (5a-e) and 2-(imino substitut

APA, Harvard, Vancouver, ISO, and other styles

2

Zonov, Yaroslav V., Siqi Wang, Vladislav V. Komarov, Victor M. Karpov, Dmitriy A. Parkhomenko, and Tatyana V. Mezhenkova. "Carbonylation of Polyfluorinated Alkylbenzenes and Benzocycloalkenes at the Benzyl C-F and C-Cl Bonds Under the Action of CO/SbF5." Molecules 30, no. 4 (2025): 931. https://doi.org/10.3390/molecules30040931.

Full text

Abstract:

The carbonylation at the benzyl C-Hal bonds (Hal = F, Cl) of a number of polyfluorinated alkylbenzenes and benzocycloalkenes using carbon monoxide in the presence of SbF5 is described. The reaction provided the corresponding α-arylcarboxylic acids or their methyl esters following aqueous or methanol treatment. The products of double carbonylation were obtained from bis(chloromethyl)tetrafluorobenzenes and benzal fluorides. For benzal chloride derivatives, the possibility of selective mono- or dicarbonylation was shown to depend on the amount of antimony pentafluoride. In the case of polyfluori

APA, Harvard, Vancouver, ISO, and other styles

3

S., M. Mohamed, Khalile M., A. Ismail A., and S. Kadh M. "Synthesis and biological activity of some new pyrazole derivatives." Journal of Indian Chemical Society Vol. 82, Sep 2005 (2005): 833–37. https://doi.org/10.5281/zenodo.5827595.

Full text

Abstract:

Chemistry Department, Faculty of Science (For Girls), Al-Azhar University, Nasr City, Egypt <em>Manuscript received 21 April 2004, revised 7 January 2005, accepted 20 June 2005</em> 1-Substituted-3-(2,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydropyrazoles were prepared via condensation or 3,4,5-(trimethoxy)benzal-2,4-(dimethoxy)acetophenone with hydrazine derivatives in ethanol and/or condensation with hydrazine hydrate in acidic medium. The product with ethyl iodide, phenyl isothiocyanate, benzoyl chloride and nitrous acid yielded the corresponding 1-substituted-3-(2,4-dimethoxyph

APA, Harvard, Vancouver, ISO, and other styles

4

Salwa Abdul Sattar Jabbar, Fawzi Hameed Jumaa, and Husniya Qadri Mawlood. "Synthesis and Characterization of some bis 1,3-Oxazepine and 2,3-Dihydroquinozoline derivatives." Tikrit Journal of Pure Science 20, no. 2 (2023): 110–20. http://dx.doi.org/10.25130/tjps.v20i2.1168.

Full text

Abstract:

In this study some new compounds have been synthesized including preparation of some different Schiff bases[1-6] from the reaction benzdine with substituted of benzal-dehyde in absolute ethanol and converted into derivatives of 1,3-oxazpines(by ring clo- sure reaction (2+5) of Schiff bases with maleic anhydride in dry benzene[7-12],also the 2,3 –dihyroquinozoline-4(1H) one[13-17] were prepared. The prepared compounds were characterized by color and melting point determination, FT-IR and UV-Vis spectral analysis . Some of the prepared compounds were identified by 1H- NMR and C.H.N spectra analy

APA, Harvard, Vancouver, ISO, and other styles

5

Ran, deep Kaur Sandhar, R. Sharma J., and R. Manrao M. "Synthesis and fungitoxicity of aldimines and 4-thiazolidinones derived from 4-bromoaniline." Journal of Indian Chemical Society Vol. 85, Feb 2008 (2008): 220–23. https://doi.org/10.5281/zenodo.5808967.

Full text

Abstract:

Department of Biochemistry and Chemistry, Punjab Agricultural University, Ludhiana-141 004, Punjab, India <em>Manuscript received 26 October 2005, revised 1 August 2007, accepted 26 November 2007</em> Condensation of 4-bromoaniline with benzaldehyde and substituted benzaldehydes (1-8) in equimolar ratio resulted in the formation of benzal-4-bromoaniline and its C-phenyl derivatives (la-8a). Addition of thioglycolic acid to la-8a yielded the respective 4-thiazolidinone (lb-8b). The synthesized compounds were characterized on the basis of elemental analysis and spectral studies and were screened

APA, Harvard, Vancouver, ISO, and other styles

6

SHIM, S. C., C. H. DOH, D. Y. LEE, et al. "ChemInform Abstract: Cobalt-Catalyzed Carbonylation of Benzal Chloride Derivatives to Alkyl Phenylacetates. Part 2." ChemInform 23, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.199222130.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Y., M. ISSA, M. OMAR M, M. ABDEL-FATTAH H., and A. SOLIMAN A. "Spectroscopic Investigation of some Thio Schiff Bases." Journal of Indian Chemical Society Vol. 73, Jan 1996 (1996): 55–59. https://doi.org/10.5281/zenodo.5892203.

Full text

Abstract:

Chemistry Depattment. Faculty of Science, Cairo University, Cairo, Egypt <em>Manuscript received 21 May 1993, revised 18 April 1994, accepted 27 May 1994</em> Schiff bases of 2-aminothiophenol with some benzaldehyde derivatives have been prepared. The effect of substitution at the benzal ring on the band positions of <sup>ʋ</sup>C=N and <sup>𝛿</sup>CH(CH=N) is investigated; the electron-withdrawing groups lower the frequency as a result of decreased electron density on the C=N linkage while electron-donating groups exert an opposite effect. Band assignment of the proper absorption band is made

APA, Harvard, Vancouver, ISO, and other styles

8

Sabaa, M. W., N. A. Mohamed, Kh D. Khalil, and A. A. Yassin. "Organic thermal stabilizers for rigid poly(vinyl chloride) II. Benzal thiobarbituric acid and some of its derivatives." Polymer Degradation and Stability 70, no. 2 (2000): 121–33. http://dx.doi.org/10.1016/s0141-3910(00)00098-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Gökçe, Mehtap, Ahmet Geciken, Engin Yıldırım, and Ali Tosun. "Synthesis and Anticonvulsant Activity of 5-Chloro-2(3H)-benzoxazolinone-3-acetyl-2-(o/p-substituted benzal) hydrazone Derivatives." Arzneimittelforschung 58, no. 11 (2011): 537–42. http://dx.doi.org/10.1055/s-0031-1296554.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Elhady, A. N. El-Sharabasy A. S. Kassab S. R. R. Soliman A. M. F. &. Ali A. A. E. "New anticorrosion and flame retardant coating compositions based on 4-amino triazole derivatives , their Schiffs' bases and epoxy varnish." International Journal of Applied Research 6, no. 1 (2020): 60–72. https://doi.org/10.5281/zenodo.4013369.

Full text

Abstract:

In this study, some recently amino triazole derivatives mainly 4-amino-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione(I),4-((furan-2-yl-methylene)amino)-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione(II), 4-((4-nitrobenzyl- idene)amino)-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (III),4-((4-(dimethylamino)benzylidene)amino)-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (IV), 5-phenyl-4-((3-phenyl-4-((3-phenylallylidene) amino)-2,4-dihydro-3H-1,2,4-triazole-3-thione(V),4-(((3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazole-4yl)imino)methyl)benzal-  dehyde(VI),and3-(((3-phenyl-5-thio

APA, Harvard, Vancouver, ISO, and other styles

11

Gökçe, Mehtap, Semra Utku, and Esra Küpeli. "Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal)hydrazone derivatives." European Journal of Medicinal Chemistry 44, no. 9 (2009): 3760–64. http://dx.doi.org/10.1016/j.ejmech.2009.04.048.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Kronenberg, M. E., and E. Havinga. "The influence of non planarity in styrene and stilbene derivatives V: Infrared spectra and conformations of cis- and trans-benzal ketones." Recueil des Travaux Chimiques des Pays-Bas 84, no. 1 (2010): 17–23. http://dx.doi.org/10.1002/recl.19650840103.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Kronenberg, M. E., and E. Havinga. "The influence of non-planarity in styrene and stilbene derivatives VI: Dipole moments and conformations of cis- and trans-benzal ketones." Recueil des Travaux Chimiques des Pays-Bas 84, no. 8 (2010): 979–84. http://dx.doi.org/10.1002/recl.19650840803.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Ashry, El Sayed H. El, Shaker Youssif, Maged El Ahwany, and Mohamed El Sanan. "Synthesis of 3-benzylxanthine and Lumazine Analogues." Journal of Chemical Research 2005, no. 4 (2005): 262–66. http://dx.doi.org/10.3184/0308234054213438.

Full text

Abstract:

Several xanthines (7–13) are prepared by the cyclisation of 1-benzyl-5,6-diaminouracil with single-carbon inserting agents such as aromatic aldehydes, formamides, acetic anhydride, carbon disulfide, and nitrous acid. Treatment of 6-amino-1-benzyl-5-nitrosouracil with anilinobenzylidene derivatives (14–18) affords 7-hydroxyxanthines (19–23). Cyclisation of the diaminouracil 3 with glyoxal, benzil, and diethyl oxalate leads to lumazines (25–28).

APA, Harvard, Vancouver, ISO, and other styles

15

Utku, Semra, Mehtap Gökçe, İlkay Orhan, and M. Şahin. "Synthesis of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/-nonsubstituted benzal)hydrazone derivatives and acetylcholinesterase and butyrylcholinesterase inhibitory activities in vitro." Arzneimittelforschung 61, no. 01 (2011): 1–7. http://dx.doi.org/10.1055/s-0031-1296161.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Havelková, Martina, Martin Studenovský, and Dalimil Dvořák. "N1-Substituted Hypoxanthine Derivatives from the Reaction of 6-Halopurines with Michael Acceptors Under the Conditions of Heck Reaction." Collection of Czechoslovak Chemical Communications 65, no. 5 (2000): 797–804. http://dx.doi.org/10.1135/cccc20000797.

Full text

Abstract:

The reaction of 6-iodo-, 9-benzyl-6-chloropurine and 7-benzyl-6-chloropurine with butyl acrylate, acrylonitrile, methyl vinyl ketone or methyl methacrylate under conditions of the Heck reaction in the presence of TlOAc or AgOAc afforded N1-alkylhypoxanthine derivatives. Formation of these unexpected products can be rationalised as a Tl+- or Ag+-assisted substitution of halogen with acetate anion. The 6-acetoxypurine derivative thus formed then eliminates ketene and gives 7-benzyl- or 9-benzylhypoxanthine. Conjugate addition of these compounds onto Michael acceptors furnishes the N1-substituted

APA, Harvard, Vancouver, ISO, and other styles

17

Song, Jin Yong, Da-Eun Jung, Sang-Jun Jung, Sang-Bae Han та Youngsoo Kim. "NF-κB-targeted intervention of acetaminophen-induced acute liver injury by benzyl indanone". Journal of Immunology 202, № 1_Supplement (2019): 187.11. http://dx.doi.org/10.4049/jimmunol.202.supp.187.11.

Full text

Abstract:

Abstract Acetaminophen (APAP, Paracetamol) is a worldwide analgesic ingredient. Acetaminophen overdose accounts for 46% of acute liver failure. The toxic mechanism of acetaminophen-induced liver injury (AILI) consists of two phases: early phase by APAP and late phase by Kupffer cell-mediated inflammation. N-acetyl cysteine, the therapeutic drug of AILI, is effective in early phase but not in late phase. Here, we focus on the innate immunosuppressant to improve AILI and demonstrate protective effect of benzyl indanone derivative on AILI. The survival rate of AILI was increased from 12% to 91% a

APA, Harvard, Vancouver, ISO, and other styles

18

Easton, CJ, та SC Peters. "Reactions of α-Substituted Glycine Derivatives With Stannanes in the Presence of Disulfides". Australian Journal of Chemistry 47, № 5 (1994): 859. http://dx.doi.org/10.1071/ch9940859.

Full text

Abstract:

Reactions of α- bromo -, α- benzoyloxy - and α- methoxy -substituted glycine derivatives with stannanes afforded the corresponding α- centred glycinyl radical, which reacted with di -t-butyl disulfide and diphenyl disulfide by homolytic substitution to give the corresponding α-t- butylthio- and α-phenylthio -substituted glycine derivatives, respectively. The glycinyl radical reacted with dibenzyl disulfide by displacement of benzyl radical to give a mixed disulfide, which was subsequently reduced to the corresponding α- benzylthio-substituted glycine derivative. In related reactions of a cysti

APA, Harvard, Vancouver, ISO, and other styles

19

Vaughn, Steven F., and Gayland F. Spencer. "Synthesis and Herbicidal Activity of Modified Monoterpenes Structurally Similar to Cinmethylin." Weed Science 44, no. 1 (1996): 7–11. http://dx.doi.org/10.1017/s0043174500093474.

Full text

Abstract:

The preemergence herbicide cinmethylin is a benzyl ether derivative of the monoterpene 1,4-cineole. Other oxygenated monoterpenes (carvone, citronellol, fenchone, geraniol, and pulegone) were previously found to inhibit the germination and growth of several weed species while exhibiting low phytotoxicity to soybean. Benzyl ether derivatives of these oxygenated monoterpenes were synthesized and examined for preemergence and postemergence activity towards corn, soybean, wheat, and velvetleaf. Benzyl pulegyl ether exhibited the most preemergence activity when applied directly to the soil, complet

APA, Harvard, Vancouver, ISO, and other styles

20

Zhang, Lizhu, Qi Zhang, Yahan Xue, Guangwei Zhou, Qunsheng Yan, and Jiarong Li. "Synthesis of 2,4,6,8,10-pentaaza[3.3.3]propellane substituted with different groups." E3S Web of Conferences 165 (2020): 05002. http://dx.doi.org/10.1051/e3sconf/202016505002.

Full text

Abstract:

Polyaza[3.3.3]propellanes have good symmetry and strong ring tension, which are suitable as the skeleton structure of functional materials such as high energy density materials. Based on the single benzyl derivative of 3,7,9.11-tetraoxo-2,4,6,8,10-pentaaza[3.3.3]propellane (compound 3 ), a series of 2,4,6,8,10- pentaaza[3.3.3]propellane derivatives, such as 4a-c and their reduced derivatives 5a-c, were synthesized successfully.

APA, Harvard, Vancouver, ISO, and other styles

21

Al-Masoudi, Najim A., Yaseen A. Al-Soud, Erik De Clercq, and Christophe Pannecouque. "Nitroimidazoles Part 6. Synthesis, Structure and in Vitro anti-HIV Activity of New 5-substituted Piperazinyl-4-nitroimidazole Derivatives." Antiviral Chemistry and Chemotherapy 18, no. 4 (2007): 191–200. http://dx.doi.org/10.1177/095632020701800403.

Full text

Abstract:

2-Amino-1-[4-(1-benzyl-2-ethyl-4-nitro-1 H-imidazol-5-yl)piperazin-1-yl]ethanone [6] was prepared from 1-(1-benzyl-2-ethyl-4-nitro-1 H-imidazol-5-yl) piperazine [3]. A series of new 2-oxoethyl-arylamide [9,10] and 2-oxoethyl-arylsulphonamide [11–14] derivatives were synthesized from [6] with the aim of developing new non-nucleoside reverse transcriptase inhibitors. Alternatively, the amine [17] was synthesized from [3] via the phthalimide derivative [16]. The arylsulphonamide derivatives [18–23] and the arylamide analogues [24–26] were synthesized from [17]. The compounds were evaluated for th

APA, Harvard, Vancouver, ISO, and other styles

22

Perich, JW, та RB Johns. "Electron Ionization and Chemical Ionization Mass Spectra of Some Nα-(t-Butoxycarbonyl)-O-(diorganylphosphono)-L-serines". Australian Journal of Chemistry 45, № 10 (1992): 1759. http://dx.doi.org/10.1071/ch9921759.

Full text

Abstract:

N α -(t- Butoxycarbonyl )-O-( diorganylphosphono )L- serines underwent a complex fragmentation under both electron ionization and chemical ionization ( isobutane ) with the dominant pathway being a function of the phosphono organyl group (phenyl, ethyl, methyl, benzyl, t-butyl). In the case of the phenyl-, ethyl- and methyl-substituted derivatives, both electron ionization (15 eV) and chemical ionization mass spectra showed that β-eliminative loss of the seryl residue was the major pathway, and that the two-step loss of the t- butoxycarbonyl group from the [MH]+ ion was a inor pathway. In the

APA, Harvard, Vancouver, ISO, and other styles

23

Dohle, Wolfgang, Xiangdong Su, Yamni Nigam, Edward Dudley, and Barry V. L. Potter. "Synthesis and In Vitro Antimicrobial SAR of Benzyl and Phenyl Guanidine and Aminoguanidine Hydrazone Derivatives." Molecules 28, no. 1 (2022): 5. http://dx.doi.org/10.3390/molecules28010005.

Full text

Abstract:

A series of benzyl, phenyl guanidine, and aminoguandine hydrazone derivatives was designed and in vitro antibacterial activities against two different bacterial strains (Staphylococcus aureus and Escherichia coli) were determined. Several compounds showed potent inhibitory activity against the bacterial strains evaluated, with minimal inhibitory concentration (MIC) values in the low µg/mL range. Of all guanidine derivatives, 3-[2-chloro-3-(trifluoromethyl)]-benzyloxy derivative 9m showed the best potency with MICs of 0.5 µg/mL (S. aureus) and 1 µg/mL (E. coli), respectively. Several aminoguani

APA, Harvard, Vancouver, ISO, and other styles

24

Kracht, Daniel, Susumu Saito, and Bernhard Wünsch. "Synthesis of 1,4-Diazabicyclo[3.3.1]nonan-6-ones." Australian Journal of Chemistry 62, no. 12 (2009): 1684. http://dx.doi.org/10.1071/ch09206.

Full text

Abstract:

1,4-Diazabicyclo[3.3.1]nonanes (aza-morphans) represent conformationally constrained piperazine derivatives. Herein, we report a six-step synthesis of the benzyl and allyl substituted bicyclic ketones 3a and 3b, which represent interesting building blocks for the synthesis of conformationally restricted receptor ligands. The key steps of the synthesis are the regioselective addition of ethyl acrylate to the piperazine 8, the sodium hexamethyldisilazide-induced Dieckmann cyclization of the diesters 10, and the decarboxylation of the enol esters 11 with dilute HCl. The complete sequence is only

APA, Harvard, Vancouver, ISO, and other styles

25

Sinaga, Cinthia Uly Hotnami, and Asep Wahyu Nugraha. "Determining the Most Stable Structure of Benzamided Derivatives Using Density Functional Theory (DFT)." Indonesian Journal of Chemical Science and Technology (IJCST) 4, no. 2 (2021): 49. http://dx.doi.org/10.24114/ijcst.v4i2.27594.

Full text

Abstract:

This study aims to determine the energy change ∆E and determine the most stable compound based on computation results using the Density Functional Theory (DFT) method. In determining the energy change ∆E and determining the most stable compound, computational chemical calculations were used using NWChem version 6.6 software with the DFT method with the B3LYP / 3-21G base set hybrid function, the results of the calculations were visualized using the Jmol software. The results of computational calculations on the compound Benzamide is 57467.3632844735 kJ / mol, (4 - chlorocarbonyl - benzial) - p

APA, Harvard, Vancouver, ISO, and other styles

26

Guo, Richard, Romelo Gibe, and James R. Green. "Mono- and disubstitutions of (hepta-2,5-diyne-1,7-diol) bis(dicobalt) derivatives Selectivity in Nicholas reactions." Canadian Journal of Chemistry 82, no. 2 (2004): 366–74. http://dx.doi.org/10.1139/v03-209.

Full text

Abstract:

Bis(hexacarbonyldicobalt) complexes of benzyl ether methyl ether or benzyl ether acetate derivatives of hepta-2,5-diyne-1,7-diols undergo selective Lewis-acid-mediated Nicholas reactions with enol silanes, silyl ketene acetals, and allylstannanes, preferentially replacing the methyl ether or acetate function. Hydride nucleophiles are similarly incorporated selectively using a benzyl ether alcohol derivative. Subsequent Nicholas reaction at the benzyloxy-bearing site may be accomplished with an identical or a different nucleophile, affording skipped 1,4-diyne-Co4(CO)12 complexes. In insta

APA, Harvard, Vancouver, ISO, and other styles

27

Akune, Yoko, Risa Hirosawa, Atsushi Koseki, and Shinya Matsumoto. "Role of halogen substituents in a series of polymorphic 2,5-diamino-3,6-dicyanopyrazine derivatives with highly flexible groups." Zeitschrift für Kristallographie - Crystalline Materials 232, no. 5 (2017): 395–405. http://dx.doi.org/10.1515/zkri-2016-2007.

Full text

Abstract:

AbstractThe crystal structures of the ortho-X-benzyl derivatives, where X=F, Cl, Br, I, and Me, of 2,5-bis(N,N-dibenzylamino)-3,6-dicyanopyrazine dyes (C34H24N6X4) were analysed to evaluate the effect of a systematic series of structures on the occurrence of polymorphism. Detailed crystal structure analysis indicated that the thermally stable forms of the polymorphic derivatives (Cl and Br derivatives) were close-packed, whereas those of the non-polymorphic derivatives (F and I derivatives) were stabilised by an intermolecular interaction involving the ortho-substituents. In the thermally meta

APA, Harvard, Vancouver, ISO, and other styles

28

Maduwantha, Kaveendra, Shigeyuki Yamada, Kaveenga Rasika Koswattage, Tsutomu Konno, and Takuya Hosokai. "Excited-State Dynamics of Room-Temperature Phosphorescent Organic Materials Based on Monobenzil and Bisbenzil Frameworks." Materials 13, no. 17 (2020): 3904. http://dx.doi.org/10.3390/ma13173904.

Full text

Abstract:

Room-temperature phosphorescent (RTP) materials have been attracting tremendous interest, owing to their unique material characteristics and potential applications for state-of-the-art optoelectronic devices. Recently, we reported the synthesis and fundamental photophysical properties of new RTP materials based on benzil, i.e., fluorinated monobenzil derivative and fluorinated and non-fluorinated bisbenzil derivative analogues [Yamada, S. et al., Beilstein J. Org. Chem. 2020, 16, 1154–1162.]. To deeply understand their RTP properties, we investigated the excited-state dynamics and photostabili

APA, Harvard, Vancouver, ISO, and other styles

29

Perich, JW, I. Liepa, AL Chaffee та RB Johns. "Fast Atom Bombardment Mass Spectra of Some N-α-(t-Butoxycarbonyl)-O-(diorganylphosphono)-L-serines and O-(Diorganylphosphono)seryl-Containing Dipeptides and Tripeptides". Australian Journal of Chemistry 47, № 2 (1994): 229. http://dx.doi.org/10.1071/ch9940229.

Full text

Abstract:

Positive and negative ion fast atom bombardment ( f.a.b .) mass spectrometry were found to be useful methods for the analysis and structural characterization of five Nα-(t- butoxycarbonyl )-O-( diorganylphosphono )-L- serines ( organyl = Ph, Et, Me, Bzl , But), especially in the case of the sensitive benzyl and t-butyl phosphono derivatives. Under positive ion operating conditions, high intensity pseudo-molecular ions were obtained in the f.a.b . mass spectra, and the fragmentation pathway of the phenyl, ethyl and methyl derivatives was established by parent/daughter linked scanning studies to

APA, Harvard, Vancouver, ISO, and other styles

30

Rádl, Stanislav, and Lenka Kovářová. "Some reactions of N-propadienyl-4-quinolones." Collection of Czechoslovak Chemical Communications 56, no. 11 (1991): 2413–19. http://dx.doi.org/10.1135/cccc19912413.

Full text

Abstract:

N-Alkylation of ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (Vg) with 3-bromopropyne followed by acidic hydrolysis provided N-propyl derivative Ic which in alkaline media yielded N-propadienyl derivative IId. Propadienyl derivatives IIa and IIb treated with primary or secondary amines provided intermediates IIIa-IIIc which were hydrolyzed to N-acetonyl derivatives IVa and IVb, respectively. N-Benzylation of ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (Va) followed by hydrolysis yielded 1-benzyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic ac

APA, Harvard, Vancouver, ISO, and other styles

31

Smrčková, Svatava, Kristina Juricová, and Viktor Prutianov. "Study of Amino-Imino Tautomerism in Derivatives of 2-, 4- and 6-Aminonicotinic Acid." Collection of Czechoslovak Chemical Communications 59, no. 9 (1994): 2057–68. http://dx.doi.org/10.1135/cccc19942057.

Full text

Abstract:

13C NMR spectra of p-nitrobenzoyl 2-, 4-, and 6-aminopyridine-3-carboxylates, their hydrochlorides, trifluoroacetates and 1-benzyl derivatives were studied. As found from the chemical shifts of pyridine carbon atoms C-2, C-4 and C-6, the free bases exist in the amino form whereas hydrochlorides and 1-substituted pyridinium derivatives in the imino form. Trifluoroacetates of the 2- and 6-amino derivatives have structure similar to that of amidiniumcarboxylates (parallel hydrogen bonds and partially ionic character) whereas trifluoroacetate of the 4-amino derivative is structurally close to the

APA, Harvard, Vancouver, ISO, and other styles

32

Long, Yueming, Zijun Xia, Allison M. Rice, and S. Bruce King. "Para-Substituted O-Benzyl Sulfohydroxamic Acid Derivatives as Redox-Triggered Nitroxyl (HNO) Sources." Molecules 27, no. 16 (2022): 5305. http://dx.doi.org/10.3390/molecules27165305.

Full text

Abstract:

Nitroxyl shows a unique biological profile compared to the gasotransmitters nitric oxide and hydrogen sulfide. Nitroxyl reacts with thiols as an electrophile, and this redox chemistry mediates much of its biological chemistry. This reactivity necessitates the use of donors to study nitroxyl’s chemistry and biology. The preparation and evaluation of a small library of new redox-triggered nitroxyl sources is described. The condensation of sulfonyl chlorides and properly substituted O-benzyl hydroxylamines produced O-benzyl-substituted sulfohydroxamic acid derivatives with a 27–79% yield and with

APA, Harvard, Vancouver, ISO, and other styles

33

BANI, TALAPAlRA, CHAKRABORTY SYAMAL, BISWAS KALLOLMAY, MONDAL SUDIPTA та KUMAR TALAPATRA SUNIL. "Friedel-Crafts Reaction with Arylcarbinols : One-Pot Synthesis of 10-Methylbenzo[ α ]fluoranthene". Journal of Indian Chemical Society Vol. 75, Oct-Dec 1998 (1998): 788–94. https://doi.org/10.5281/zenodo.5923195.

Full text

Abstract:

Centre of Advanced Studies on Natural Products, Department of Chemistry, University College of Science, 92 Acharya Prafulla Chandra Road, Calcutta-700 <em>009</em> <em>Manuscript received 14 September 1998</em> Friedel-Crafts reaction with some monoaryl and diaryl carbinols have been studied. The products suggest a rational mode of formation of trityl alcohol and anthracene derivatives modifying the earlier reported conjecture of their formation from carbon monoxide, generated from benzhydrol and solvent benzene. It now appears that during Friedel-Crafts reaction the benzyl carbocation generat

APA, Harvard, Vancouver, ISO, and other styles

34

Fenton, Ronald R., Leonard F. Lindoy, Jason R. Price, Brian W. Skelton, and Allan H. White. "New Macrocyclic Ligands. XVI. Synthesis of a Series of N-Benzylated Macrocycles Incorporating N4O2-Donor Set." Australian Journal of Chemistry 56, no. 11 (2003): 1141. http://dx.doi.org/10.1071/ch03079.

Full text

Abstract:

The synthesis of five 20-membered, N-benzylated macrocyclic ligands incorporating N4O2-donor sets and from one to three benzyl substituents for use in metal-ion recognition studies is described. The new derivatives were obtained by both benzylation of the pre-formed parent macrocycle using benzyl chloride in acetonitrile in the presence of base or, in one case, by performing macrocyclic ring closure using the appropriate N-benzylated triamine precursor by means of a bis-Schiff base condensation with the corresponding dialdehyde, followed by in situ reduction of the diamine linkages so formed.

APA, Harvard, Vancouver, ISO, and other styles

35

Counsell, Andrew J., Angus T. Jones, Matthew H. Todd, and Peter J. Rutledge. "A direct method for the N-tetraalkylation of azamacrocycles." Beilstein Journal of Organic Chemistry 12 (November 18, 2016): 2457–61. http://dx.doi.org/10.3762/bjoc.12.239.

Full text

Abstract:

An efficient protocol for the direct synthesis of N-tetraalkylated derivatives of the azamacrocycles cyclam and cyclen has been developed, using a partially miscible aqueous–organic solvent system with propargyl bromide, benzyl bromide, and related halides. The method works most effectively when the reaction mixture is shaken, not stirred. A crystal structure of the N-tetrapropargyl cyclam derivative 1,4,8,11-tetra(prop-2-yn-1-yl)-1,4,8,11-tetraazacyclotetradecane diperchlorate is reported.

APA, Harvard, Vancouver, ISO, and other styles

36

A. Abdulqader, Kany, Ahmed W. Naser, Muthanna S. Farhan та Sabah J. Salih. "Synthesis, Characterization and Cytotoxic Activity of some new 1,2,3-Triazole, Oxadiazole and Aza- β-lactam Derivatives". Oriental Journal of Chemistry 34, № 5 (2018): 2350–60. http://dx.doi.org/10.13005/ojc/340516.

Full text

Abstract:

A series of 1,2,3-triazole, oxadiazole and aza-β-lactam derivatives were synthesized through consecutive reaction began from o-(N-propargyl) sulfonamido benzoic acid (1a). The reaction of (1a) with absolute ethanol in the presence of concentrated H2SO4 resulted in the formation of ester derivative (2a). The product of the previous reaction was reacted with 80% hydrazine hydrate to prepare benzohydrazide derivative (3a). 1,3,4-oxadiazole compound (4a) was obtained by condensation of compound (3a) with CS2 in presence KOH . Compound (3a) react with Phenyl isocyanates to give Carboxamide derivati

APA, Harvard, Vancouver, ISO, and other styles

37

Dvořáková, Hana, Antonín Holý, and Ivan Rosenberg. "Synthesis of Some 2'-C-Alkyl Derivatives of 9-(2-Phosphonomethoxyethyl)adenine and Related Compounds." Collection of Czechoslovak Chemical Communications 59, no. 9 (1994): 2069–94. http://dx.doi.org/10.1135/cccc19942069.

Full text

Abstract:

To study the effect of β-substitution in 2'-alkyl derivatives of 9-(2-phosphonomethoxyethyl)adenine (Ia) on the antiviral activity or group specificity, these derivatives were synthesized. 9-(2-Hydroxyalkyl)adenines VIII were prepared by alkylation of adenine with suitably substituted oxiranes XIII or 2-hydroxyalkyl p-toluenesulfonates IV and VI. After protection of the adenine amino group by benzoylation (compounds IX) or amidine formation (compounds X), the intermediates were alkylated with diisopropyl p-toluenesulfonyloxymethanephosphonate (XI) in the presence of sodium hydride. After depro

APA, Harvard, Vancouver, ISO, and other styles

38

Perich, JW, PF Alewood, and RB Johns. "Synthesis of Casein-Related Peptides and Phosphopeptides. VIII. The Synthesis of Ser(P)-Containing Peptides by the Use of Z-Ser(PO3R2)-OH Derivatives." Australian Journal of Chemistry 44, no. 2 (1991): 253. http://dx.doi.org/10.1071/ch9910253.

Full text

Abstract:

.The synthesis of five Z-Ser(PO3R2)-OH (R = phenyl, ethyl, methyl, benzyl, t-butyl) derivatives is described by a simple three-step synthetic procedure which features the use of either (A) diphenyl or dialkyl phosphorochloridate /pyridine or (B) dialkyl N,N-diethylphosphoramidite/1H-tetrazole-m-chloroperoxybenzoic acid for the phosphorylation of the serine hydroxy group. The benzyl phosphate derivative, Z-Ser(PO3Bzl2)-OH, was used in the benzyloxycarbonyl mode of peptide synthesis for the preparation of Z-Ser(PO3Bzl2)-Leu-OBzl and Z-Ser(PO3Bzl2)-Ser(PO3Bzl2)- OBzl which were deprotected by pal

APA, Harvard, Vancouver, ISO, and other styles

39

Koike, Daiki, Hyuma Masu, Haruka Uno, Shoko Kikkawa, Hidemasa Hikawa, and Isao Azumaya. "Spherical Amides with C3 Symmetry: Improved Synthetic Approach and Structural/Optical Analysis." Molecules 30, no. 5 (2025): 1074. https://doi.org/10.3390/molecules30051074.

Full text

Abstract:

A spherical amide with C3 symmetry was synthesized by a one-step cyclization reaction using triphenylphosphine and hexachloroethane as coupling reagents. This method enabled synthesis of N-benzyl and N-allyl derivatives, which could not be obtained by the previously reported method. The optical resolution of each compound was measured, and their electronic circular dichroism spectra revealed that they were mirror images. The high structural symmetry resulted in a higher Δε (molar absorption difference against right or left circular polarization: εL − εR value compared to that of another struct

APA, Harvard, Vancouver, ISO, and other styles

40

Koperniku, Ana, Maryam Zamiri, and David Grierson. "The Reaction of N-Trimethylsilyl-Substituted Heteroarylamines with Esters and Thioesters: An Efficient Protocol To Access Diheteroarylamides." Synthesis 51, no. 08 (2019): 1779–90. http://dx.doi.org/10.1055/s-0037-1611435.

Full text

Abstract:

The S-benzyl thioester and methyl ester derivatives of a representative 4-pyridinone-based carboxylic acid were sufficiently activated to react efficiently in amide coupling reactions with the amide anion generated in situ from the N-trimethylsilyl derivative of different weakly nucleophilic heteroarylamines. In acetonitrile as solvent, the precipitated diheteroarylamide products were isolated in pure form by vacuum filtration. This simple amide bond forming protocol can be readily adapted to the parallel synthesis of compound libraries.

APA, Harvard, Vancouver, ISO, and other styles

41

Kim, Hyoungsu, Seung-Hoon Baek, and Hongjun Jang. "Synthesis and Biological Evaluation of Acetylcholinesterase Inhibitor Macakurzin C and Its Derivatives." Synlett 26, no. 08 (2015): 1131–34. http://dx.doi.org/10.1055/s-0034-1380193.

Full text

Abstract:

The derivatives of macakurzin C containing a modified D ring and protected C(3)/C(5)-hydroxyl groups were synthesized and their in vitro AChE inhibitory activity and neurotoxicity were evaluated to identify the structural requirements for the activities. The results indicated that C(3)-benzyl-protected derivative has a more potent AChE inhibitory activity (IC50, 2.6 μM) and a less neurotoxicity (GI50, >100 μM) than synthetic macakurzin C (IC50, 9.1 μM; GI50, 16.6 μM).

APA, Harvard, Vancouver, ISO, and other styles

42

Rubekina, Anna A., Polina N. Kamzeeva, Vera A. Alferova, et al. "Hydrophobic Rose Bengal Derivatives Exhibit Submicromolar-to-Subnanomolar Activity against Enveloped Viruses." Biomolecules 12, no. 11 (2022): 1609. http://dx.doi.org/10.3390/biom12111609.

Full text

Abstract:

Rose Bengal (RB) is an anionic xanthene dye with multiple useful biological features, including photosensitization properties. RB was studied extensively as a photosensitizer, mostly for antibacterial and antitumor photodynamic therapy (PDT). The application of RB to virus inactivation is rather understudied, and no RB derivatives have been developed as antivirals. In this work, we used a synthetic approach based on a successful design of photosensitizing antivirals to produce RB derivatives for virus photoinactivation. A series of n-alkyl-substituted RB derivatives was synthesized and evaluat

APA, Harvard, Vancouver, ISO, and other styles

43

Tong, Kelvin K. H., Muhammad Hanif, James H. Lovett, et al. "Thiourea-Derived Chelating Ligands and Their Organometallic Compounds: Investigations into Their Anticancer Activity." Molecules 25, no. 16 (2020): 3661. http://dx.doi.org/10.3390/molecules25163661.

Full text

Abstract:

Thiones have been investigated as ligands in metal complexes with catalytic and biological activity. We report the synthesis, characterization, and biological evaluation of a series of MII/III complexes of the general formulae [MII(cym)(L)Cl]X (cym = η6-p-cymene) or [MIII(Cp*)(L)Cl]X (Cp* = η5-pentamethylcyclopentadienyl), where X = Cl− or PF6−, and L represents heterocyclic derivatives of thiourea. The thiones feature a benzyl-triazolyl pendant and they act as bidentate ligands via N,S-coordination to the metal centers. Several derivatives have been investigated by single-crystal X-ray diffra

APA, Harvard, Vancouver, ISO, and other styles

44

Kotek, Jan, Pavel Vojtíšek, Ivana Císařová, et al. "Bis(methylphosphonic Acid) Derivatives of 1,4,8,11-Tetraazacyclotetradecane (Cyclam). Synthesis, Crystal and Molecular Structures, and Solution Properties." Collection of Czechoslovak Chemical Communications 65, no. 8 (2000): 1289–316. http://dx.doi.org/10.1135/cccc20001289.

Full text

Abstract:

Cyclam derivatives with methylphosphonic acid arms in position 1,8 and substituent R = H, Me, CH2Ph in positions 4 and 11 are synthesised by Mannich reaction of an appropriate cyclam derivative, formaldehyde and phosphonic acid/diethyl phosphite followed by removal of protecting benzyl groups from nitrogen atoms. Mono(methylphosphonic acid) derivative of cyclam can be obtained by a similar route. Crystal structures of four phosphonic acid derivatives show the same ring conformation and orientation pendants due to strong intramolecular hydrogen bonds between phosphonate oxygen atoms and protona

APA, Harvard, Vancouver, ISO, and other styles

45

Sonali, Sarkar, Shil Suranjan, and Misra Anirban. "DFT based study on the mechanism of an unexpected reaction of aldehydes with 1,3-dicarbonyl compounds." Journal of Indian Chemical Society Vol. 91, Jul 2014 (2014): 1289–97. https://doi.org/10.5281/zenodo.5726235.

Full text

Abstract:

Department of Chemistry, University of North Bengal, Siliguri-734 013, West Bengal, India <em>E-mail</em> : anirbanmisra@yahoo.com <em>Manuscript received online 25 June 2013, revised 12 January 2014, accepted 24 February 2014</em> The mechanism of an unexpected reaction between two molecules of 1,3-dicarbonyl compound and one molecule of the aldehyde to selectively provide spiro dihyrofuran and cyclopropane derivatives promoted by molecular iodine and dimethylaminopyridine has been investigated by density functional theory based approach. The geometries and the frequencies of reactants, inter

APA, Harvard, Vancouver, ISO, and other styles

46

Al-Soud, Yaseen A., Najim A. Al-Masoudi, Hossam H. Al-Suod, and Christophe Pannecouque. "Nitroimidazoles Part 8. Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives Using the Suzuki Cross-Coupling Reaction." Zeitschrift für Naturforschung B 67, no. 9 (2012): 925–34. http://dx.doi.org/10.5560/znb.2012-0185.

Full text

Abstract:

The development of new HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating structures of increased potency. To this end, a series of 1-(1-benzyl-2-ethyl- 4-nitro-1H-imidazol-5-yl)-4-(1,1'-biaryl)-4-yl-piperazine derivatives (6a-l) was synthesized via the Suzuki coupling reaction. Analogously, coupling of the acid derivative 5, prepared from 4, with various amino acid methyl esters in the presence of HOBt/DCC reagents afforded the benzamide derivatives 8-11. The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT- 4 cells. All com

APA, Harvard, Vancouver, ISO, and other styles

47

Trisovic, Nemanja, Bojan Bozic, Ana Obradovic, et al. "Structure-activity relationships of 3-substituted-5,5- diphenylhydantoins as potential antiproliferative and antimicrobial agents." Journal of the Serbian Chemical Society 76, no. 12 (2011): 1597–606. http://dx.doi.org/10.2298/jsc110314143t.

Full text

Abstract:

A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature. Their antiproliferative activities against HCT-116 human colon carcinoma cells were evaluated to determine structure-activity relationships. Almost all of the compounds exhibited statistically significant antiproliferative effects at a concentration of 100 ?M, while the derivative bearing a benzyl group was active even at lower concentrations. Moreover, their in vitro antibacterial activities against Escherichia coli ATCC 25922, S

APA, Harvard, Vancouver, ISO, and other styles

48

Li, Wen, Shu-Yi Chen, Wei-Nan Hu, et al. "Design, synthesis, and biological evaluation of quinazoline derivatives containing piperazine moieties as antitumor agents." Journal of Chemical Research 44, no. 9-10 (2020): 536–42. http://dx.doi.org/10.1177/1747519820910384.

Full text

Abstract:

A series of novel quinazoline derivatives containing piperazine analogs are synthesized via substitution reactions with 6,7-disubstituted 4-chloroquinazoline and benzyl piperazine (amido piperazine). Potent antiproliferative activities are observed against A549, HepG2, K562, and PC-3 with N-(3-chlorophenyl)-2-(4-(7-methoxy-6-(3-morpholino-propoxy)quinazoline-4-yl)piperazine-1-yl)acetamidename C9 showing excellent activity. This active derivative was screened for cell migration ability, proliferation effects, and apoptosis against A549 and PC-3 cells, with the result showing biological activity

APA, Harvard, Vancouver, ISO, and other styles

49

Sudbeck, Elise A., Chen Mao, Rakesh Vig, T. K. Venkatachalam, Lisa Tuel-Ahlgren, and Fatih M. Uckun. "Structure-Based Design of Novel Dihydroalkoxybenzyloxopyrimidine Derivatives as Potent Nonnucleoside Inhibitors of the Human Immunodeficiency Virus Reverse Transcriptase." Antimicrobial Agents and Chemotherapy 42, no. 12 (1998): 3225–33. http://dx.doi.org/10.1128/aac.42.12.3225.

Full text

Abstract:

ABSTRACT Two highly potent dihydroalkoxybenzyloxopyrimidine (DABO) derivatives targeting the nonnucleoside inhibitor (NNI) binding site of human immunodeficiency virus (HIV) reverse transcriptase (RT) have been designed based on the structure of the NNI binding pocket and tested for anti-HIV activity. Our lead DABO derivative, 5-isopropyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-one, elicited potent inhibitory activity against purified recombinant HIV RT and abrogated HIV replication in peripheral blood mononuclear cells at nanomolar concentrations (50% inhibitory concentration,

APA, Harvard, Vancouver, ISO, and other styles

50

Al-Soud, Yaseen, Najim Al-Masoudi, Hamed Hassan, Erik De Clercq, and Christophe Pannecouque. "Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivatives." Acta Pharmaceutica 57, no. 4 (2007): 379–93. http://dx.doi.org/10.2478/v10007-007-0031-7.

Full text

Abstract:

Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivativesA series of 2-alkylthio-1-[4-(1-benzyl-2-ethyl-4-nitro-1H- -imidazol-5-yl)-piperazin-1-y]lethanones (3-9) and alkyl- [4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)-piperazin- -1-yl)ketones (11-20) as well as the indole analogue22were synthesized from 4-nitro-5-piperazinyl imidazole derivative1, with the aim to develop newly non-nucleoside reverse transcriptase inhibitors (NNRTIs). The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compound2showed i

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!