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Journal articles on the topic 'Benzamids'

Author: Grafiati

Published: 5 June 2025

Last updated: 15 July 2025

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1

Butterhof, Christian, Thomas Martin, and Josef Breu. "Neue polymorphe Form des Benzamids." Zeitschrift für anorganische und allgemeine Chemie 638, no. 10 (2012): 1617. http://dx.doi.org/10.1002/zaac.201204101.

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2

Mondal, Pradip Kumar, Rahul Shukla, Subha Biswas, and Deepak Chopra. "Role of halogen-involved intermolecular interactions and existence of isostructurality in the crystal packing of —CF3 and halogen (Cl or Br or I) substituted benzamides." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 74, no. 6 (2018): 574–91. http://dx.doi.org/10.1107/s2052520618013422.

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A total of 23 benzamides are obtained through a simple reaction between chloro-/bromo-/iodoaniline and trifluoromethylbenzoyl chloride and characterized using single-crystal X-ray diffraction. Crystal structures of three series of benzamides based on N-chlorophenyl–trifluoromethyl–benzamide (nine compounds), N-bromophenyl–trifluoromethyl–benzamide (six compounds), and N-iodophenyl–trifluoromethyl–benzamide (eight compounds) are prepared to analyse the halogen-mediated noncovalent interactions. The influences of Cl/Br/I and trifluoromethyl substituents on the respective interactions are examine

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3

Hasana, Ani Riani, Siswandono Siswandono, and Marcellino Rudyanto. "Synthesis and characterization of 2-Benzamido-NBenzylbenzamide Derivative." JURNAL ILMU KEFARMASIAN INDONESIA 20, no. 2 (2022): 281. http://dx.doi.org/10.35814/jifi.v20i2.1135.

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Anthranilamide derivatives exhibit anti-inflammatory, antipyretic, antibacterial, antiangiogenic, and anticoagulant properties. With an early in silico examination of its analgesic capabilities, this study aimed to generate a novel anthranilamide molecule by altering 2-Benzamido-N-Benzylbenzamide. Modification of anthranilamide with 1/2/3-chloro benzoyl chloride by acylation resulted in the design, synthesis, characterization, and research of the analgesic effects of 2-benzamido-N-benzoylbenzamide derivatives. 2-(2-chlorobenzamido)-N-(2-chlorobenzoyl)benzamide, 2-(3-chlorobenzamido)-N-(3-chlor

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4

Kushwaha, Mr Abhay, Dr Shailesh Jain, Mr Ajay Kumar, Mr Ritesh Raj, Dr Phool Singh Yaduwanshi, and Dr Dhanraj Patidar. "An Overall Review of Different Derivatives That Activate Glucokinase Enzyme Having Multiple Actions to Treat Type 2 Diabetes." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 358–67. https://doi.org/10.35629/4494-1001358367.

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Different derivatives like3,6-disubstituted2- pyridine carboxamide derivatives, Phenylethyl benzamide derivatives, Carboxypyridine benzamide derivatives, Pyrazole benzamide derivatives, Quinazoline-2,4 dione analogs, Ketopiperazine analogs, Cycloalkyl-fused Nthiazol-2-yl-benzamides derivatives, 1,4- disubstituted indazoles derivatives, 2,5,6- trisubstituted indole derivatives, Azaindole derivatives andPyrimidone derivatives was designed, synthesized and evaluated the pharmacological activity in mice. Such compounds activate the glucokinase by interaction between glucokinase activators and gluc

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5

Tummino, P. J., P. J. Harvey, T. McQuade, et al. "The human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein zinc ejection activity of disulfide benzamides and benzisothiazolones: correlation with anti-HIV and virucidal activities." Antimicrobial Agents and Chemotherapy 41, no. 2 (1997): 394–400. http://dx.doi.org/10.1128/aac.41.2.394.

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It has been shown previously by our group and others that a series of four disulfide benzamides with cellular anti-human immunodeficiency virus (HIV) activity can eject zinc from HIV type 1 nucleocapsid protein (NCp7) in vitro while analogs without antiviral activity do not. We also found that the zinc ejection activity correlates with the loss of the ability of NCp7 to bind to HIV psi RNA in vitro. These observations indicate that the antiviral disulfide benzamides may act at a novel retroviral target of action, i.e., the nucleocapsid protein. The present studies examine the relationship amon

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6

Mehmood, Hina, Muhammad Asif Iqbal, Muhammad Naeem Ashiq, and Ruimao Hua. "Base-Promoted One-Pot Synthesis of Pyridine Derivatives via Aromatic Alkyne Annulation Using Benzamides as Nitrogen Source." Molecules 26, no. 21 (2021): 6599. http://dx.doi.org/10.3390/molecules26216599.

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In the presence of Cs2CO3, the first simple, efficient, and one-pot procedure for the synthesis of 3,5-diaryl pyridines via a variety of aromatic terminal alkynes with benzamides as the nitrogen source in sulfolane is described. The formation of pyridine derivatives accompanies the outcome of 1,3-diaryl propenes, which are also useful intermediates in organic synthesis. Thus, pyridine ring results from a formal [2+2+1+1] cyclocondensation of three alkynes with benzamides, and one of the alkynes provides one carbon, whilst benzamides provide a nitrogen source only. A new transformation of alkyn

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7

H. Al-Hazmi, Ghaferah. "Design, synthesis, and cytotoxic activity of some novel N-(substituted) benzamide derivatives bearing coumarin and 1-azocoumarin compounds." Bulletin of the Chemical Society of Ethiopia 37, no. 4 (2023): 1003–19. http://dx.doi.org/10.4314/bcse.v37i4.16.

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ABSTRACT. Among oxygen-containing heterocyclic compounds such as coumarin and azacoumarin derivatives, the scaffold has become an important construction motif for developing new drugs. Coumarin and its derivatives possess many types of biological activities and have been reported to show significant cytotoxic activity. N-(6,8-disubstituted coumarin-3-yl)benzamides (8a-c) namely (3-N-(benzoyl) aminocoumarin-6-ylmethyl acetate (8a); N-[6-(1-acetylpyrazol-3-yldiazineyl) coumarin-3-yl] benzamide (8b); N-(8-methoxy-6-bromo-coumarin-3-yl) benzamide (8c), were synthesized via a cyclocondensation reac

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8

Miyaji, Ryota, Yuuki Wada, Akira Matsumoto, Keisuke Asano, and Seijiro Matsubara. "Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides." Beilstein Journal of Organic Chemistry 13 (August 2, 2017): 1518–23. http://dx.doi.org/10.3762/bjoc.13.151.

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Bifunctional organocatalysts bearing amino and urea functional groups in a chiral molecular skeleton were applied to the enantioselective synthesis of axially chiral benzamides via aromatic electrophilic bromination. The results demonstrate the versatility of bifunctional organocatalysts for the enantioselective construction of axially chiral compounds. Moderate to good enantioselectivities were afforded with a range of benzamide substrates. Mechanistic investigations were also carried out.

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9

Ha, Nguyen Van Vinh, Nguyen Thi Thu Ha, Ong Ngoc Khanh, Dinh Truc Phuong, Ho Thanh Nhat, and Nguyen Thanh Tung. "Copper promoted, directed sulfenylation and phenoxylation of benzamide C−H bonds." Vietnam Journal of Chemistry 61, no. 2 (2023): 204–9. http://dx.doi.org/10.1002/vjch.202200119.

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AbstractHerein we reported a method for copper pivalate mediated, directed functionalization of ortho C−H bonds in (2‐methylthio)aniline benzamides. Diaryl disulfides were used for thiolation, while successful phenoxylation was obtained with phenol as the coupling agent. Our report marks a rare example for flexible transformation of benzamide C(sp2)−H bonds into the corresponding unsymmetrical diaryl ethers and thioethers.

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10

Saljooghi, Arman Shokooh, Hojatollah Khabazzadeh, and Moj Khaleghi. "Efficient Synthesis of Novel Thioureidobenzamido Alkyl Naphthols in Molten Tetrabutylammonium Bromide." Letters in Organic Chemistry 16, no. 11 (2019): 906–10. http://dx.doi.org/10.2174/1570178616666190123120127.

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A new series of benzamido alkyl naphthols were synthesized from the multi-component reaction of 4-(3′-methylthioureido)benzamide, aromatic aldehydes and 2-naphthol. Molten tetrabutyl ammonium bromide was used as a very efficient medium for this reaction while the use of common organic solvents gave no or poor yields. This method is an interesting instance of using molten salt as a medium in multicomponent reactions.

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11

Janabi, Mustafa, Catherine M. Pollock, Ann-Marie Chacko, and Duncan H. Hunter. "Resin-supported arylstannanes as precursors for radiolabeling with iodine: benzaldehydes, benzoic acids, benzamides, and NHS esters." Canadian Journal of Chemistry 93, no. 2 (2015): 207–17. http://dx.doi.org/10.1139/cjc-2014-0265.

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A highly cross-linked polystyrene resin bearing a reactive chlorostannane moiety 1 has been used to generate a variety of arylstannane radiopharmaceutical precursors for no-carrier-added radioiodination. The resins were characterized for their solvent compatibility and sensitivity to acid cleavage. Resin-supported arylstannanes synthesized via their aryllithium analogues include 3- and 4-stannylbenzaldehydes, 3- and 4-stannylbenzoic acids, and 3- and 4-N-succinimidyl benzoates. A three-step route to the resin-supported stannylbenzoic acids 12a/b was developed through resin-supported benzaldehy

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12

Cunico, Wilson, Maria de Lourdes G. Ferreira, James L. Wardell, and William T. A. Harrison. "Different intra- and intermolecular hydrogen-bonding patterns in (3S,4aS,8aS)-2-[(2R,3S)-3-(2,5-X2-benzamido)-2-(2,5-X2-benzoyloxy)-4-phenylbutyl]-N-tert-butyldecahydroisoquinoline-3-carboxamides (X= H or Cl): compounds with moderate aspartyl protease inhibition activity." Acta Crystallographica Section E Crystallographic Communications 73, no. 6 (2017): 913–17. http://dx.doi.org/10.1107/s2056989017007800.

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The crystal structures of (3S,4aS,8aS)-2-[(2R,3S)-3-benzamido-2-benzoyloxy-4-phenylbutyl]-N-tert-butyldecahydroisoquinoline-3-carboxamide, C38H47N3O4, (I), and (3S,4aS,8aS)-2-[(2R,3S)-3-(2,5-dichlorobenzamido)-2-(2,5-dichlorobenzoyloxy)-4-phenylbutyl]-N-tert-butyldecahydroisoquinoline-3-carboxamide, C38H43Cl4N3O4, (II), are described. Despite their chemical similarity, they adopt different conformations in the solid state: (I) features a bifurcated intramolecular N—H...(N,O) hydrogen bond from thetert-butylamide NH group to the piperidine N atom and the benzoate O atom, whereas (II) has an int

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13

Harish Chinthal, Chayanna, Hemmige S. Yathirajan, Anish Kumar Kadambar, Balakrishna Kalluraya, Sabine Foro, and Christopher Glidewell. "Two N-{[4-(3-aryl-4-sydnonylideneamino)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl}benzamides as disordered ethanol monosolvates." Acta Crystallographica Section E Crystallographic Communications 76, no. 7 (2020): 1057–61. http://dx.doi.org/10.1107/s2056989020007483.

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Two new N-{[4-(3-aryl-4-sydnonylideneamino)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl}benzamides have been prepared by acid-promoted condensation reactions between 3-aryl-4-formylsydnones and N-[(4-amino-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methyl]benzamide, and both have been crystallized as ethanol monosolvates. N-{[4-(3-Phenyl-4-sydnonylideneamino)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl}benzamide ethanol monosolvate, C19H15N7O3S·C2H6O (I), and N-({4-[3-(4-methylphenyl)-4-sydnonylideneamino]-5-sulfanylidene-1H-1,2,4-triazol-3-yl}methyl)benzamide ethanol monosolvate, C20H17N7O3S·C2H

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14

Sović, Irena, Maja Cindrić, Nataša Perin, et al. "Biological potential of novel methoxy and hydroxy substituted heteroaromatic amides designed as promising antioxidative agents: Synthesis, 3D-QSAR analysis and biological activity." Chemical Research in Toxicology 32, no. 9 (2019): 1880.1892. https://doi.org/10.1021/acs.chemrestox.9b00256.

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This paper discusses antioxidative and biological activities of 25 novel amidino substituted benzamides with a variety of heteroaromatic nuclei attached to the benzamide moiety and with a variable number of methoxy or hydroxy substituents. Targeted compounds, bearing either amidino or 2-imidazolinyl substituent, were obtained in the Pinner reaction from cyano precursors. 3D-QSAR models were generated to predict antioxidative activity of the 25 novel aromatic and heteroaromatic benzamide derivatives. The compounds were tested for antioxidative activity using <em>in vitro</em> spectrop

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15

Vairoletti, Franco, Margot Paulino, Graciela Mahler, Gustavo Salinas, and Cecilia Saiz. "Structure-Based Bioisosterism Design, Synthesis, Biological Evaluation and In Silico Studies of Benzamide Analogs as Potential Anthelmintics." Molecules 27, no. 9 (2022): 2659. http://dx.doi.org/10.3390/molecules27092659.

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A recent screen of 67,012 compounds identified a new family of compounds with excellent nematicidal activity: the ortho-substituted benzamide families Wact-11 and Wact-12. These compounds are active against Caenorhabditis elegans and parasitic nematodes by selectively inhibiting nematode complex II, and they display low toxicity in mammalian cells and vertebrate organisms. Although a big number of benzamides were tested against C. elegans in high-throughput screens, bioisosteres of the amide moiety were not represented in the chemical space examined. We thus identified an opportunity for the d

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16

Ouahrouch, Abdelaaziz, Moha Taourirte, Hassan B. Lazrek, Joachim W. Engels, and Michael Bolte. "Crystal structure of 2-benzamido-N-(2,2-diethoxyethyl)benzamide." Acta Crystallographica Section E Crystallographic Communications 71, no. 3 (2015): o214—o215. http://dx.doi.org/10.1107/s2056989015003370.

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In the title compound, C20H24N2O4, both peptide bonds adopt atransconfiguration with respect to the —N—H and —C=O groups. The dihedral angle between the aromatic rings is 53.58 (4)°. The molecular conformation is stabilized by an intramolecular N—H...O hydrogen bond. The crystal packing is characterized by zigzag chains of N—H...O hydrogen-bonded molecules running along theb-axis direction.

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17

To Anh, Tuong, Trang Nguyen Thi Thuy, Anh Nguyen Thai, and Nam Phan Thanh Son. "Cu2(BDC)2DABCO as an efficient heterogeneous catalyst for the oxidative C-N coupling reaction between amides and unactivated alkanes." Vietnam Journal of Catalysis and Adsorption 9, no. 1 (2020): 67–72. http://dx.doi.org/10.51316/jca.2020.011.

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A copper-organic framework Cu2(BDC)2DABCO was synthesized, and used as a recyclable heterogeneous catalyst for C-N coupling reaction between benzamide and cyclohexane. 94% yield of N-cyclohexylbenzamide was achieved under the optimized condition. The copper-organic framework catalyst was truly heterogeneous and could be used at least 4 cycles without degradation of catalytic performance. To the best of our knowledge, the amidation of unactivated alkanes by benzamides via direct oxidative C-N coupling was previously performed under heterogeneous catalysis conditions but very rare.

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18

Furlan, Berenice, Marta Sobrinos-Sanguino, Marcella Sammartino, et al. "Targeting Bacterial Cell Division with Benzodioxane–Benzamide FtsZ Inhibitors as a Novel Strategy to Fight Gram-Positive Ovococcal Pathogens." International Journal of Molecular Sciences 26, no. 2 (2025): 714. https://doi.org/10.3390/ijms26020714.

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The widespread emergence of antimicrobial resistance (AMR) is a serious threat to global public health and among Gram-positive cocci, Streptococcus pneumoniae constitutes a priority in the list of AMR-threatening pathogens. To counteract this fundamental problem, the bacterial cell division cycle and the crucial proteins involved in this process emerged as novel attractive targets. FtsZ is an essential cell division protein, and FtsZ inhibitors, especially the benzamide derivatives, have been exploited in the last decade. In this work, we identified, for the first time, some benzodioxane–benza

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19

Barlin, GB, LP Davies, B. Glenn, PW Harrison, and SJ Ireland. "Imidazo[1,2-b]pyridazines. XV. Synthesis and Anxiolytic Activity of Some 3-(Benzamidomethyl and fluorobenzamidomethyl)-6-(fluoro, chloro and methylthio)-2-(4-tolyl and 3,4-methylenedioxyphenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 47, no. 4 (1994): 609. http://dx.doi.org/10.1071/ch9940609.

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Syntheses are reported for some 3-( benzamido-and fluorobenzamido -methyl)-6-( fluoro , chloro and methylthio )-2(4-methyl-, 4-t-butyl-, 4-cyclohexyl- and 3,4-methylenedioxy-phenyl) imidazo-[1,2-b] pyridazines from the relevant 3-unsubstituted imidazo [1,2-b] pyridazines and the N-( hydroxymethyl ) benzamides. In tests of the ability of these compounds to displace [3H]diazepam from rat brain membrane, 3-(3- or 4-fluorobenzamidomethyl)-2-(3,4-methylenedioxyphenyl)-6-methylthioimidazo[1,2-b]- pyridazine bound most strongly, with IC50 2nM; but in behavioural tests in rats the most active compound

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20

Gardner, Barry, Angeline J. S. Kanagasooriam, Richard M. Smyth, and Andrew Williams. "Mechanism of Alkaline Cyclization of 2-(Substituted benzamido)benzamides to 4-Quinazolinones." Journal of Organic Chemistry 59, no. 21 (1994): 6245–50. http://dx.doi.org/10.1021/jo00100a026.

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21

Ozheredov, D. S., and P. A. Karpov. "Comparative analysis of allosteric rearrangements in FtsZ protein structure induced by benzamide and 4-hydroxycoumarine compounds." Faktori eksperimental'noi evolucii organizmiv 35 (September 25, 2024): 164–69. http://dx.doi.org/10.7124/feeo.v35.1679.

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Aim. To reveal allosteric rearrangements of FtsZ molecules arising under the influence of benzamide compounds and 4-hydroxycoumarin derivatives. To discover the key molecular mechanisms predetermining the effect of the specified compounds on the cell division in bacteria. Methods. Comparative analysis of FtsZ protein structures and their complexes with ligands. Application of structural bioinformatics software for molecular visualization, measurement of interatomic distances and approximation of intramolecular shifts based on RMSD indicators. Results. Revealed conformational changes in FtsZ pr

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22

Stanishevskiy, V. V., A. K. Schestakova, and V. A. Chertkov. "Dynamic Structure of Organic Compounds in Solution According to NMR Data and Quantum Mechanical Calculations: IV. Benzamide." Журнал органической химии 59, no. 8 (2023): 1012–24. http://dx.doi.org/10.31857/s0514749223080025.

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To study the structure and dynamics of nitrogen-containing compounds, NMR parameters with directly involved nitrogen can provide valuable structure information. However, this information can only be obtained using15N-enriched compounds due to low natural abundance of 15N and extremely short relaxation of 14N nuclei. For synthesis of these compounds from 15N-ammonium salts, 15N-enriched benzamides often used as intermediates. In the present work, we study the dynamic structure of benzamide caused by two independent factors: hindered internal rotation of the NH2 group around the C(O)-N bond and

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23

Zheng, Yang, Susanne Schroeder, Georgi K. Kanev, et al. "To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?" International Journal of Molecular Sciences 24, no. 7 (2023): 6817. http://dx.doi.org/10.3390/ijms24076817.

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Schistosomiasis is a neglected tropical disease with high morbidity. Recently, the Schistosoma mansoni phosphodiesterase SmPDE4A was suggested as a putative new drug target. To support SmPDE4A targeted drug discovery, we cloned, isolated, and biochemically characterized the full-length and catalytic domains of SmPDE4A. The enzymatically active catalytic domain was crystallized in the apo-form (PDB code: 6FG5) and in the cAMP- and AMP-bound states (PDB code: 6EZU). The SmPDE4A catalytic domain resembles human PDE4 more than parasite PDEs because it lacks the parasite PDE-specific P-pocket. Puri

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24

Lee, Tae-Kyung, Preethi Ravindranathan, Rajni Sonavane, Ganesh V. Raj, and Jung-Mo Ahn. "A Structure—Activity Relationship Study of Bis-Benzamides as Inhibitors of Androgen Receptor—Coactivator Interaction." Molecules 24, no. 15 (2019): 2783. http://dx.doi.org/10.3390/molecules24152783.

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The interaction between androgen receptor (AR) and coactivator proteins plays a critical role in AR-mediated prostate cancer (PCa) cell growth, thus its inhibition is emerging as a promising strategy for PCa treatment. To develop potent inhibitors of the AR–coactivator interaction, we have designed and synthesized a series of bis-benzamides by modifying functional groups at the N/C-terminus and side chains. A structure–activity relationship study showed that the nitro group at the N-terminus of the bis-benzamide is essential for its biological activity while the C-terminus can have either a me

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25

Li, Yawen, Ming-Kuan Chyan, Donald K. Hamlin, Holly Nguyen, Eva Corey, and D. Scott Wilbur. "Oxidation of p-[125I]Iodobenzoic Acid and p-[211At]Astatobenzoic Acid Derivatives and Evaluation In Vivo." International Journal of Molecular Sciences 23, no. 18 (2022): 10655. http://dx.doi.org/10.3390/ijms231810655.

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The alpha particle-emitting radionuclide astatine-211 (211At) is of interest for targeted radiotherapy; however, low in vivo stability of many 211At-labeled cancer-targeting molecules has limited its potential. As an alternative labeling method, we evaluated whether a specific type of astatinated aryl compound that has the At atom in a higher oxidation state might be stable to in vivo deastatination. In the research effort, para-iodobenzoic acid methyl ester and dPEG4-amino acid methyl ester derivatives were prepared as HPLC standards. The corresponding para-stannylbenzoic acid derivatives wer

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26

Gomes, Ligia R., John Nicolson Low, Catarina Oliveira, Fernando Cagide, and Fernanda Borges. "Crystal structures of three 3,4,5-trimethoxybenzamide-based derivatives." Acta Crystallographica Section E Crystallographic Communications 72, no. 5 (2016): 675–82. http://dx.doi.org/10.1107/s2056989016005958.

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The crystal structures of three benzamide derivatives,viz. N-(6-hydroxyhexyl)-3,4,5-trimethoxybenzamide, C16H25NO5, (1),N-(6-anilinohexyl)-3,4,5-trimethoxybenzamide, C22H30N2O4, (2), andN-(6,6-diethoxyhexyl)-3,4,5-trimethoxybenzamide, C20H33NO6, (3), are described. These compounds differ only in the substituent at the end of the hexyl chain and the nature of these substituents determines the differences in hydrogen bonding between the molecules. In each molecule, them-methoxy substituents are virtually coplanar with the benzyl ring, while thep-methoxy substituent is almost perpendicular. The c

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27

Belz, Tyson, Saleh Ihmaid, Jasim Al-Rawi, and Steve Petrovski. "Synthesis Characterization and Antibacterial, Antifungal Activity of N-(Benzyl Carbamoyl or Carbamothioyl)-2-hydroxy Substituted Benzamide and 2-Benzyl Amino-Substituted Benzoxazines." International Journal of Medicinal Chemistry 2013 (October 31, 2013): 1–20. http://dx.doi.org/10.1155/2013/436397.

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New N-(benzyl carbamothioyl)-2-hydroxy substituted benzamides 13, 20, and 21 were synthesized using sodium bicarbonate and benzyl amine with 2-thioxo-substituted-1,3-benzoxazines 6, 10a, b, 11c, and 12a–n. The 2-thioxo-substituted-1,3-oxazines 6, 10a-b, 11d 12a–n, and 26 were converted to the corresponding 2-methylthio-substituted-1,3-oxazines 14a–l and 24 which were then converted to 2-benzyl amino-substituted-benzoxazines 15a–i by refluxing with benzylamine. Products 15a, b, e, f, and g were also synthesized by boiling the corresponding N-(benzyl carbamothioyl)-2-hydroxy substituted benzamid

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28

Cox, Robin A. "Benzamide hydrolysis in strong acids — The last word." Canadian Journal of Chemistry 86, no. 4 (2008): 290–97. http://dx.doi.org/10.1139/v08-015.

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Recently it has become apparent that the mechanism of amide hydrolysis in relatively dilute strong acid media is the same as the one observed for ester and benzimidate hydrolysis, two water molecules reacting with the O-protonated amide in the rate-determining step. This is not the whole story, however, at least for benzamide, N-methylbenzamide, and N,N-dimethylbenzamide, since the observed rate constants for these substrates deviate upwards from the observed excess acidity correlation lines at acidities higher than about 60% H2SO4, meaning that another, faster, reaction with a different mecha

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29

Hermann, Theresa, Patrick Hochegger, Johanna Dolensky, et al. "New Acyl Derivatives of 3-Aminofurazanes and Their Antiplasmodial Activities." Pharmaceuticals 14, no. 5 (2021): 412. http://dx.doi.org/10.3390/ph14050412.

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An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure–activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their phenyl ring affected the activity and the cytotoxicity of compounds. In addition, physicochemical parameters

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30

Kenny, Andrew, Alba Pisarello, Arron Bird, Paula G. Chirila, Alex Hamilton, and Christopher J. Whiteoak. "A challenging redox neutral Cp*Co(III)-catalysed alkylation of acetanilides with 3-buten-2-one: synthesis and key insights into the mechanism through DFT calculations." Beilstein Journal of Organic Chemistry 14 (September 10, 2018): 2366–74. http://dx.doi.org/10.3762/bjoc.14.212.

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Traditional, established palladium cross-coupling procedures are widely applied in complex molecule synthesis; however, there is a significant disadvantage in the requirement for pre-functionalised substrates (commonly halides/triflates). Direct C–H activation protocols provide the opportunity for a novel approach to synthesis, although this field is still in its relative infancy and often transferability between substrate classes remains unresolved and limitations not fully understood. This study focuses on the translation of an established Cp*Co(III)-catalysed alkylation of benzamides to rel

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31

Rocco, Daniele, Isabella Chiarotto, Leonardo Mattiello, Fabiana Pandolfi, Daniela Zane, and Marta Feroci. "Electrochemical synthesis and amidation of benzoin: benzamides from benzaldehydes." Pure and Applied Chemistry 91, no. 10 (2019): 1709–15. http://dx.doi.org/10.1515/pac-2018-1118.

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Abstract The benzoin condensation starting from benzaldehyde and the subsequent benzoin amidation to benzamide can be efficiently carried out under very mild conditions in an electrolysis cell. Among the advantages of using electrochemistry to generate our active reagents, the use of the easily dosed and non pollutant electron, instead of stoichiometric amounts of redox reagents or bases, usually renders the electrochemical methodology “greener” than classical organic reactions. Benzoin is obtained in good yield (85 %) carrying out the reaction in the room temperature ionic liquid BMIm-BF4. In

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32

Warude, Bhagyashri J., Sandip N. Wagh, Vivekanda A. Chatpalliwar, et al. "Design, docking, MD simulation and in-silco ADMET prediction studies of novel indole-based benzamides targeting estrogen receptor alfa positive for effective breast cancer therapy." Pharmacia 70, no. 2 (2023): 307–16. http://dx.doi.org/10.3897/pharmacia.70.e100356.

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Breast cancer is one of the most common malignancies in women, afflicting millions of lives each year. Our current study suggests that the development of the most promising 7-substituted -1-(4-(piperidine-1-yl methoxy)benzyl)-1H-indole-3-carboxamide derivatives results in potent anticancer agents through in-silico investigations. The molecular docking was performed against estrogen receptor alpha (ER-α) positive (PDB ID: 3UUD) of breast cancer cells to anticipate the binding modes of the designed compounds and the likely mode of action. The interactions between the ligands and amino acid resid

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33

Parmar, Dharmishtha R., and B. N. Suhagia. "QSAR Study of N-((3-Benzamido-4-oxo-3,4-Dihydroquinazolin 2-yl)methyl)-N-(Substituted) Phenyl Benzamide as Antiulcer Agents." International Journal of Quantitative Structure-Property Relationships 8, no. 1 (2023): 1–14. http://dx.doi.org/10.4018/ijqspr.320179.

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Suppression of gastric acid secretion by use of proton pump inhibitors is an efficient way to control hyperacidity complications. An inhibitory activity of N-((3-Benzamido-4-oxo-3, 4 dihydro quinazolin -2-yl) methyl)-N-(substituted phenyl) benzamides on H+/K+-ATPase was established and reported earlier. Thus, it is significant to develop more promising agents by quantitative structure-activity relationship (QSAR) study of 37 ligands by multi-linear regression method to link the structures of molecules with inhibitory activity on H+/K+-ATPase (pIc50). QSAR model was built using genetic function

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34

Warude, Bhagyashri J., Sandip N. Wagh, Vivekanda A. Chatpalliwar, et al. "Design, docking, MD simulation and in-silco ADMET prediction studies of novel indole-based benzamides targeting estrogen receptor alfa positive for effective breast cancer therapy." Pharmacia 70, no. (2) (2023): 307–16. https://doi.org/10.3897/pharmacia.70.e100356.

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Breast cancer is one of the most common malignancies in women, afflicting millions of lives each year. Our current study suggests that the development of the most promising 7-substituted -1-(4-(piperidine-1-yl methoxy)benzyl)-1H-indole-3-carboxamide derivatives results in potent anticancer agents through in-silico investigations. The molecular docking was performed against estrogen receptor alpha (ER-α) positive (PDB ID: 3UUD) of breast cancer cells to anticipate the binding modes of the designed compounds and the likely mode of action. The interactions between the ligands and amino acid resid

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35

Zhu, Bao Hua, Guo Hua Xu, and Zhi Wei Xia. "Ruthenium and Iron Carbonyl Clusters Catalyzed Reduction of N,N-dimethylbenzamide and N,N-diethyl-(3-methyl)benzamide." Advanced Materials Research 396-398 (November 2011): 2485–88. http://dx.doi.org/10.4028/www.scientific.net/amr.396-398.2485.

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One new Ruthenium and one known Iron bimetallic carbonyl clusters containing triphos (1,1,1-tris(diphenylphosphinomethyl)ethane) ligand have been prepared as catalyst to study the reduction of amide to amine. All clusters were characterized by elemental analysis, 1HNMR, 31PNMR and IR spectroscopy. The reduction of N,N-dimethylbenzamide and N,N-diethyl-(3-methyl) benzamide catalyzed by Ru and Fe carbonyl clusters were investigated at 100 ~ 110 °C for 24 ~ 28h, polymethylhydrogensiloxane (PMHS) as reduction agent. The products were analysized using GC-MS, IR and UV-vis spectroscopy and an excell

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36

Limban, Carmen, Lia M. Diţu, Luminița Măruțescu, et al. "Design, Synthesis and Biopharmacological Profile Evaluation of New 2-((4- Chlorophenoxy)Methyl)-N-(Arylcarbamothioyl)Benzamides with Broad Spectrum Antifungal Activity." Current Organic Chemistry 23, no. 12 (2019): 1365–77. http://dx.doi.org/10.2174/1385272823666190621162950.

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The emerging antifungal resistance represents a major challenge for the treatment of severe fungal infections, highlighting the need to develop novel and efficient antifungal compounds. This study aimed to synthesize new title compounds and screen them for their antifungal activity in order to generate highly accurate structure - activity relationships of 2-((4-chlorophenoxy)methyl)-N-(arylcarbamothioyl)benzamides and their de novo derivatives and to unveil some of their mechanisms of action by flow cytometry and fluorescence microscopy. The presence of functional groups was confirmed for nine

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37

Pearson, Wayne H., Joseph J. Urban, Amy H. Roy MacArthur, Shirley Lin, and Dylan W. L. Cabrera. "Crystal structures of N-[4-(trifluoromethyl)phenyl]benzamide and N-(4-methoxyphenyl)benzamide at 173 K: a study of the energetics of conformational changes due to crystal packing." Acta Crystallographica Section E Crystallographic Communications 78, no. 3 (2022): 297–305. http://dx.doi.org/10.1107/s2056989022000950.

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As a part of our study of the syntheses of aryl amides, the crystal structures of two benzamides were determined from single-crystal X-ray data at 173 K. Both crystal structures contain molecular units as asymmetric units with no solvent in the unit cells. Crystal structure I, TFMP, is the result of the crystallization of N-[4-(trifluoromethyl)phenyl]benzamide, C14H10F3NO. Crystal structure II, MOP, is composed of N-(4-methoxyphenyl)benzamide, C14H13NO2, units. TFMP is triclinic, space group P\overline{1}, consisting of two molecules in the unit cell related by the center of symmetry. MOP is m

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Baek, Heung Soo, Soo Mi Ahn, Byoung Young Woo, et al. "Whitening Effects of Adamantyl Benzamide Derivatives." Journal of the Society of Cosmetic Scientists of Korea 39, no. 2 (2013): 127–32. http://dx.doi.org/10.15230/scsk.2013.39.2.127.

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39

Wade, P. R., G. M. Mawe, T. A. Branchek, and M. D. Gershon. "Use of stereoisomers of zacopride to analyze actions of 5-hydroxytryptamine on enteric neurons." American Journal of Physiology-Gastrointestinal and Liver Physiology 260, no. 1 (1991): G80—G90. http://dx.doi.org/10.1152/ajpgi.1991.260.1.g80.

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Two subtypes of excitatory 5-hydroxytryptamine (5-HT) receptor, 5-HT1P and 5-HT3, are found on type 2-AH neurons of the guinea pig myenteric plexus. The 5-HT1P receptor mediates a slow and the 5-HT3 receptor a fast depolarization of these cells, however, the role of these receptors in the physiology of the gut is unknown. Renzapride (BRL 24924), a substituted benzamide, has previously been found to antagonize responses of myenteric neurons mediated by both 5-HT1P and 5-HT3 receptors. The effects on myenteric type 2-AH neurons of a structurally similar benzamide, zacopride, which unlike renzapr

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40

Moir, Michael, Rochelle Boyd, Hendra Gunosewoyo, Andrew P. Montgomery, Mark Connor, and Michael Kassiou. "Synthesis and evaluation of various heteroaromatic benzamides as analogues of –ylidene-benzamide cannabinoid type 2 receptor agonists." Tetrahedron Letters 60, no. 36 (2019): 151019. http://dx.doi.org/10.1016/j.tetlet.2019.151019.

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41

Balkrishna, Shah Jaimin, Rahul Shukla, Jerry P. Jasinski, and Sangit Kumar. "Crystal Structure Studies on Some of Benzamide Ring Substituted Isoselenazolones and Symmetric Diaryl Monoselenides Derived from Benzamides." Proceedings of the National Academy of Sciences, India Section A: Physical Sciences 84, no. 2 (2014): 165–77. http://dx.doi.org/10.1007/s40010-014-0129-5.

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42

Bisz, Elwira, Pamela Podchorodecka, Hengzhao Li, Wioletta Ochędzan-Siodłak, Jie An, and Michal Szostak. "Sequential Iron-Catalyzed C(sp2)–C(sp3) Cross-Coupling of Chlorobenzamides/Chemoselective Amide Reduction and Reductive Deuteration to Benzylic Alcohols." Molecules 28, no. 1 (2022): 223. http://dx.doi.org/10.3390/molecules28010223.

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Benzylic alcohols are among the most important intermediates in organic synthesis. Recently, the use of abundant metals has attracted significant attention due to the issues with the scarcity of platinum group metals. Herein, we report a sequential method for the synthesis of benzylic alcohols by a merger of iron catalyzed cross-coupling and highly chemoselective reduction of benzamides promoted by sodium dispersion in the presence of alcoholic donors. The method has been further extended to the synthesis of deuterated benzylic alcohols. The iron-catalyzed Kumada cross-coupling exploits the hi

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43

Kranjc, Krištof, Marijan Kočevar, and Franc Perdih. "Methyl 2-benzamido-4-(3,4-dimethoxyphenyl)-5-methylbenzoate andN-{5-benzoyl-2-[(Z)-2-methoxyethenyl]-4-methylphenyl}benzamide." Acta Crystallographica Section C Crystal Structure Communications 67, no. 6 (2011): o201—o205. http://dx.doi.org/10.1107/s0108270111015794.

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44

Sagar, Belakavadi K., Hemmige S. Yathirajan, Ravindranath S. Rathore, and Christopher Glidewell. "Four closely related N-(3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)benzamides: order versus disorder, and similar molecular conformations but different modes of supramolecular aggregation, with a new disordered refinement of 2-amino-3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophene." Acta Crystallographica Section C Structural Chemistry 74, no. 1 (2018): 45–53. http://dx.doi.org/10.1107/s2053229617017326.

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Four closely related N-(3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)benzamides, bearing different substituents on the benzamide ring, have been synthesized and structurally characterized. In each of N-(3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-fluorobenzamide, C22H18FNO2S, (I), N-(3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-chlorobenzamide, C22H18ClNO2S, (II), N-(3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2,6-difluorobenzamide, C22H17F2NO2S, (III), and N-(3-benzoyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-methoxybenzamide, C23H21NO3S, (IV), the last of which

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45

Nakanishi, Shinobu, and Edwin M. Uyeki. "Benzamide on chondrocytic differentiation in chick limb bud cell culture." Development 85, no. 1 (1985): 163–75. http://dx.doi.org/10.1242/dev.85.1.163.

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Benzamide, an inhibitor of (ADP-ribose) transferase, augmented chondrocytic differentiation of chick limb bud mesenchymal cells in micromass cultures; the incorporation of 35SO42− into the trichloroacetic-acid-insoluble constituents of cell masses as well as the formation of cartilage nodules (Nishio, Nakanishi, Doull & Uyeki, 1983) occurred about 24h earlier than in untreated cultures and continued to be enhanced in benzamide-treated cultures of stage 23- to 24-chick limb bud cells. Benzamide also significantly increased cell proliferation. However, benzamide did not affect DNA and RNA sy

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Mohammadi-Farani, Ahmad, Sara Nazari, Mahsa Mohammadi, Sahar Jamshidy Navid, Amin Hosseini, and Alireza Aliabadi. "Novel acetylcholinesterase inhibitors: Synthesis, docking and inhibitory activity evaluation of 4-benzamido-N-(1-benzylpiperidin-4-yl) benzamide derivatives." Results in Chemistry 7 (January 2024): 101273. http://dx.doi.org/10.1016/j.rechem.2023.101273.

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47

Mohammed Ayoob, Mzgin, and Farouq Emam Hawaiz. "Synthesis, crystal structure, DFT calculation and Hirshfeld surface analysis of N-(4-methyl phenyl)-2-(3-nitro-benzamido) benzamide." Bulletin of the Chemical Society of Ethiopia 38, no. 1 (2023): 229–39. http://dx.doi.org/10.4314/bcse.v38i1.17.

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A new bis amide N-(4-methylphenyl)-2-(3-nitrobenzamide) benzamide was synthesized from a ring-opening reaction of 2-(3-nitrophenyl)-4H-benzoxazin-4-one, with 4-methyl aniline in a shorten reaction time (1.0 min) and characterized using different spectroscopic techniques (FT-IR, 1H-NMR, 13C-NMR) and single-crystal X-ray diffraction (XRD). In the crystal lattice, the molecules are linked by N–H···O and C–H···O hydrogen bonds. The Hirshfeld surface analysis mapped over shape index, curvedness indices, dnorm revealed strong H...H and H...O/O...H and intermolecular connections a key contributors to

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48

Braña, Miguel F., María L. López Rodríguez, José M. Castellano, Purificación Fernández та Amando Garrido-Pertierra. "Reaction ofN-(4-Pyridylrnethyl)benzamideN-oxides andN-[(α-acetoxy)-4-pyridylmethyl]benzamides with 1,3-diphenyl-1,3-propanedione". Journal of Heterocyclic Chemistry 27, № 2 (1990): 401–5. http://dx.doi.org/10.1002/jhet.5570270255.

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49

Alcaide, María M., Daniel García Garrido, Eleuterio Álvarez, and Riccardo Peloso. "N-(diisopropylphosphanyl)benzamide." Molbank 2023, no. 2 (2023): M1667. http://dx.doi.org/10.3390/m1667.

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N-(diisopropylphosphanyl)benzamide, PhC(O)NHPiPr2, has been synthesized in good yield following two alternative procedures that employ benzamide as the starting material. The first one is a two-step preparation, in which N-(trimetilsilyl)benzamide is reacted with PiPr2Cl to give the title compound in good yield, whereas the second one is a straightforward synthesis which converts benzamide into N-(diisopropylphosphanyl)benzamide by reaction with PiPr2Cl in the presence of N,N-dimethylpyridin-4-amine (DMAP) and triethylamine. NMR spectroscopy and X-ray diffraction analyses have been performed t

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50

Xia, Hua, and Sheng Hui Zhang. "Synthesis, Characterization and Mechanism of Benzamide Intercalated Kaolinite by Replacement Method." Applied Mechanics and Materials 420 (September 2013): 222–29. http://dx.doi.org/10.4028/www.scientific.net/amm.420.222.

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Kaolinite/benzamide complex was prepared by displacement reaction of a kaolinite/dimethylsulphoxide (DMSO) intercalation complex with melted benzamide. The whole process was recorded by powder X-ray diffractometry (PXRD) and Fourier-transformed infrared spectroscopy (FTIR). Those PXRD and FT-IR indicated that there are two stages in the process of melted benzamide replacing intercalation. The first stage is the deintercalation of DMSO molecules in the kaolinite/dimethylsulphoxide intercalation complex. And the second stage is the melted benzamide intercalation.

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