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Dissertations / Theses on the topic 'Benzimidazol'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Orellana, Bustos María José. "Estudio de estabilidad hidrolítica de N-(p-clorobenzoil)-2-(o-nitrofenil)-benzimidazol y N-(p-flúorbenzoil)-2-(o-nitrofenil)-benzimidazol." Tesis, Universidad de Chile, 2009. http://www.repositorio.uchile.cl/handle/2250/105315.

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2

Quezada, Aburto Cristián Salvador. "Desarrollo de metodologías analíticas para la cuantificación y caracterización de 2-(o-nitrofenil)-benzimidazol y N-benzoil-2-(o-nitrofenil)-benzimidazol." Tesis, Universidad de Chile, 2007. http://repositorio.uchile.cl/handle/2250/105625.

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En esta Memoria se presenta el desarrollo y la puesta punto de metodologías analíticas reproducibles y selectivas, y su posterior aplicación en estudios de degradación de 2-(o-nitrofenil)-benzimidazol (NB) y N-benzoil-2-(o-nitrofenil)-benzimidazol (BNB). Dichos estudios se llevaron a cabo usando las técnicas de polarografía de pulso diferencial (PPD), polarografía tast (PTAST), voltametría cíclica (VC), espectrofotometría UV-Vis, cromatografía líquida de alta eficiencia (HPLC) y además estudios computacionales de modelamiento molecular.

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3

Huang, Shih-Huang. "Synthesis and characterization of 2-chloro-3-benzylthiopyrrolo[1,2-a]- benzimidazol-1-one and 2,3-di(benzylthio)pyrrolo[1,2-a]benzimidazol-1-one." Thesis, University of North Texas, 2003. https://digital.library.unt.edu/ark:/67531/metadc4415/.

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The reaction between o-phenylenediamine and 2,3-dichloromaleic anhydride has been probed and found to give 2,3-dichloropyrrolo[1,2-a]- benzimidazol-1-one as the major product. Chlorine substitution in 2,3-dichloropyrrolo[1,2-a]benzimidazol-1-one by added benzylthiol occurs in the presence of pyridine to provide the corresponding monosulfide and disulfide derivatives. The first benzylthiol ligand undergoes reaction at the C-3 position of the five-membered pyrrolo-1-one ring, with the addition of the second benzylthiol ligand occurring at the remaining chlorine-substituted carbon. The mono- and

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4

Martin, Lesley-Ann. "Early detection of resistance to meth benzimidazol-2YL- carbamate (MBC)." Thesis, University of Reading, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333544.

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5

Konzuch, Sarah [Verfasser]. "Strukturoptimierung von antiplasmodial aktiven Pyrrolopyrazol-, Benzimidazol- und Fosmidomycin-Derivaten / Sarah Konzuch." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1125658118/34.

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6

Travers, Guy. "New bis(benzimidazol-2-ylidene)pyridine-nickel complexes as homogeneous catalysts." Thesis, Curtin University, 2015. http://hdl.handle.net/20.500.11937/450.

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New nickel-based catalysts for carbon-carbon bond formation reactions were synthesized and tested. The catalysts were found to be effective, but not strongly influenced by changes in the catalyst structure. During the course of this work, an organic precursor was found to catalyse the decomposition of dimethylsulfoxide. A product of the decomposition was isolated in good yield and identified. This product was found to be a useful reagent for epoxidation reactions.

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7

Möllmann, Lars [Verfasser]. "Benzimidazol-Analoga als Modulatoren von ABC-Transportern / Lars Möllmann. Mathematisch-Naturwissenschaftliche Fakultät." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/101620003X/34.

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8

Meyer, Anja. "Verbreitung von Benzimidazol-Resistenzen bei den Trichostrongyliden von Schafen und Ziegen in der Schweiz /." Zürich : Zentralstelle der Studentenschaft, 2001. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009587265&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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9

Hinz, Susanne. "Wasserfreie Protonenleiter für Brennstoffzellen auf der Basis von Imidazol und Benzimidazol Synthese und Charakterisierung /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975973525.

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10

Cerda, Cavieres Christopher David. "Síntesis de Derivados N-Benzoil-2-(2-Nitrofenil)-1-Hbenzimidazoles. Desarrollo de Metodologías Analíticas y Caracterización Fisicoquímica de N-(p-Flúor)-Benzoil-2-(2-Nitrofenil)-Benzimidazol y N-(p-Nitro)-Benzoil -2-(2 Nitrofenil)-Benzimidazol." Tesis, Universidad de Chile, 2008. http://repositorio.uchile.cl/handle/2250/105700.

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La presente Memoria se orientó al estudio y caracterización electro-analítica de una serie de derivados N-(4-R-benzoil)-2-(2-nitrofenil)-1-H-benzimidazoles como sustratos de interés biológico. Los compuestos estudiados fueron sintetizados a partir de 2-(o-nitrofenil)-benzimidazol, generado por condensación entre 1,2-diamino-benceno y 2-nitrobenzaldehído. Posterior reacción del benzimidazol con una serie de cloruros de aroílo, generó la serie de cuatro N-(4-R-benzoil)-2-(2-nitrofenil)-1-H-benzimidazoles en buen rendimiento (R = NO2, Cl, F), con la excepción del producto denominado PMNB (R =

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11

Püttner, Miriam [Verfasser]. "Kontinuierliche versus diskontinuierliche Benzimidazol Therapie bei Patienten mit bestätigter nichtresektabeler hepatischer alveolärer Echinokokkose / Miriam Püttner." Ulm : Universität Ulm, 2018. http://d-nb.info/1161008594/34.

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12

Wu, Guanmin. "Synthesis and Characterization of 2,3-Dichloropyrrolo[1,2-a]benzimidazol-1-one and Its Methylthiol Derivatives." Thesis, University of North Texas, 2006. https://digital.library.unt.edu/ark:/67531/metadc5238/.

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Condensation of 2,3-dichloromaleic anhydride and o-phenylenediamine in refluxing toluene affords the three compounds 2,3-dichloro-N-o-C6H4(NH2)maleimide (1), N,N¢-o-C6H4-bis(2,3-dichloromaleimide) (2), and 2,3-dichloropyrrolo[1,2-a]benzimidazol-1-one (3), with compound 1 as the major product. Repeating the same reaction in the presence of added PTSA furnishes compound 3 as the major product. Treatment of 3 with methylthiol in the presence of pyridine affords monosulfide compounds 2-chloro-3-methylthiopyrrolo[1,2-a]benzimidazol-1-one (4) and and the disulfide derivatives 2,3-di(methylthio)pyrro

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13

Catalán, Díaz Mabel Elizabeth. "Estudio Electroquímico y Espectroscópico de la Interacción de Nuevos Compuestos Derivados 2-(O-Nitrofenil)-Benzimidazol con ADN." Tesis, Universidad de Chile, 2007. http://repositorio.uchile.cl/handle/2250/105639.

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En esta Memoria se informa el estudio de la interacción en solución de nuevas moléculas benzimidazólicas, 2-(o-nitrofenil)-benzimidazol (NB) y N-benzoil-2-(onitrofenil)-benzimidazol (BNB) con ADN. Para esto, se trabajó con moléculas de ADN de simple hebra (ssADN) y doble hebra (dsADN). Mediante voltamperometría de pulso diferencial sobre un electrodo de carbono vítreo se obtuvo una señal analítica para NB y BNB correspondiente a la reducción del grupo nitro presente en cada una de las estructuras estudiadas. Ambos compuestos presentaron una disminución en la intensidad de corriente en p

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14

Nunes, Ronaldo Luiz. "Análise genética de isolados do Haemonchus sp de ruminantes domésticos para identificação da resistência ao anti-helmíntico Benzimidazol." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/BUOS-8ZSPBV.

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The purpose of this study is to genetically characterize the resistance to benzimidazole (BZ) anthelmintic in Haemonchus sp helminths isolated from ruminants. With this purpose, thirty animals from herds of cattle, goats, sheep and buffalos, had stool samples collected and analyzed for the presence of trichostrongylus eggs. Properties were evaluated as for the history of using BZ to control nematodes. In herds of cattle and sheep, BZ has been used for over ten years whereas in herds of buffalos and goats, it has not been used for at least five years. Among the 120 animals tested, eighteen (~15

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15

Ara?jo, Antonio Marcos Urbano de. "S?ntese e caracteriza??o de complexos de Co(II) e Ni(II) com l-dopa, carbidopa e benzimidazol." Universidade Federal do Rio Grande do Norte, 2016. http://repositorio.ufrn.br/handle/123456789/21134.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-08-09T22:44:45Z No. of bitstreams: 1 AntonioMarcosUrbanoDeAraujo_TESE.pdf: 3225313 bytes, checksum: e25ff75db18347413666f8caf426a50e (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-08-10T22:25:30Z (GMT) No. of bitstreams: 1 AntonioMarcosUrbanoDeAraujo_TESE.pdf: 3225313 bytes, checksum: e25ff75db18347413666f8caf426a50e (MD5)<br>Made available in DSpace on 2016-08-10T22:25:30Z (GMT). No. of bitstreams: 1 AntonioMarcosUrbanoDeAraujo_TESE.pdf: 3225313 bytes, checksum: e25ff

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16

Soares, Thiago Freitas. "Resistência à corrosão dos aços inoxidáveis em soluções contendo íons cloreto e piridina ou benzimidazol como inibidores de corrosão." reponame:Repositório Institucional da UFES, 2014. http://repositorio.ufes.br/handle/10/1612.

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Submitted by Elizabete Silva (elizabete.silva@ufes.br) on 2015-10-16T20:23:13Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Resistência à corrosão dos aços inoxidáveis em soluções contendo íons cloreto e piridina ou benzimidazol como inibidores de corrosão.pdf: 6910306 bytes, checksum: 4f05297c50443551a305770e3986163c (MD5)<br>Approved for entry into archive by Patricia Barros (patricia.barros@ufes.br) on 2015-11-17T13:13:46Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Resistência

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17

SOARES, T. F. "Resistência a Corrosão dos Aços Inoxidáveis em Soluções Contendo Íons Cloreto e Piridina Ou Benzimidazol Como Inibidores de Corrosão." Universidade Federal do Espírito Santo, 2014. http://repositorio.ufes.br/handle/10/4702.

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Made available in DSpace on 2016-08-29T15:35:34Z (GMT). No. of bitstreams: 1 tese_7495_Thiago Freitas Soares.pdf: 6737866 bytes, checksum: fd5f9bd241f2dbd6dc0aa4031c94b47a (MD5) Previous issue date: 2014-03-13<br>A corrosão dos aços inoxidáveis AISI 304 e AISI 430 foi investigada em uma solução de NaCl 3% em massa na ausência e presença dos inibidores piridina ou benzimidazol. O estudo eletroquímico foi realizado utilizando a técnica de polarização potenciodinâmica e Espectroscopia de Impedância Eletroquímica (EIE), a morfologia da superfície dos eletrodos foi caracterizada utilizando as téc

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18

Hwang, Jae-Seon. "Identifizierung neuer inhibitorischer Substanzen gegen das humane Cytomegalievirus." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/16038.

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Die Verpackung und Spaltung konkatemerer DNA ist ein essentieller Prozeß bei der Reifung von Virionen. Die an diesem Prozess maßgeblich beteiligten Proteine werden als Terminase bezeichnet. Die Inhibition der HCMV Terminase bietet einen attraktiven alternativen Ansatzpunkt für die antivirale Therapie. Zur Inhibition der Terminase Aktivität wurden die neuen Benzimidazol D-Ribonukleosid Derivate BTCRB und Cl4RB auf ihre antivirale Wirkung analysiert. Die neuen Benzimidazol D-Ribonukleosid Derivate BTCRB und Cl4RB zeigten sowohl gegen den HCMV Laborstamm AD169 als auch gegen klinische HCMV-Isolat

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19

Reis, Esther Camilo dos [UNESP]. "Docking e análise do modo de ligação de três moléculas pequenas, um benzimidazol e dois compostos de crômio, nos sulcos do DNA 5'-CGCGAATTCGCG-3." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/88485.

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Made available in DSpace on 2014-06-11T19:23:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-04-10Bitstream added on 2014-06-13T18:50:41Z : No. of bitstreams: 1 reis_ec_me_bauru.pdf: 1547855 bytes, checksum: c064de6707319508d31999121d801d42 (MD5)<br>Secretaria de Educação do Estado de São Paulo<br>Neste trabalho foi estudado o modo de ligação de três moléculas pequenas ao DNA 5'-CGCGAATTCGCG-3', através da simulação computacional e análise em tela gráfica. Verificou-se que é possível utilizar o programa GOLD, baseado em algoritmos genéticos, em estudos envolvendo o DNA, uma vez que

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20

Reis, Esther Camilo dos. "Docking e análise do modo de ligação de três moléculas pequenas, um benzimidazol e dois compostos de crômio, nos sulcos do DNA 5'-CGCGAATTCGCG-3 /." Bauru : [s.n.], 2008. http://hdl.handle.net/11449/88485.

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Orientador: Ignez Caracelli<br>Banca: Francisco Carlos Lavarda<br>Banca: Regina Helena de Almeida Santos<br>O Programa de Pós-Graduação em Ciência e Tecnologia de Materiais, PosMat, tem caráter institucional e integra as atividades de pesquisa em materiais de diversos campi da Unesp<br>Resumo: Neste trabalho foi estudado o modo de ligação de três moléculas pequenas ao DNA 5'-CGCGAATTCGCG-3', através da simulação computacional e análise em tela gráfica. Verificou-se que é possível utilizar o programa GOLD, baseado em algoritmos genéticos, em estudos envolvendo o DNA, uma vez que até o momento h

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21

Durand, Andrée. "Étude de la métabolisation du chlorhydrate de 2-(parochloro alpha-hydroxybenzyl) benzimidazole (HBBPC) : étude pharmacologique de molécules apparentées." Université Joseph Fourier (Grenoble), 1990. http://www.theses.fr/1990GRE18003.

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22

Loui͏̈a, Franck. "Les inhibiteurs des "pompes" à protons gastriques : recherches, développements, synthèses chimiques, mécanismes d'action et relations structure-activité." Paris 5, 1994. http://www.theses.fr/1994PA05P253.

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23

Alasmary, Fatmah Ali Saeed. "Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents : an investigation into the synthesis of substituted benzimidazoles and their evaluation in vitro for antimicrobial activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6325.

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Microbe resistence is a serious issue, especially as they have become resistant to most well known drugs. Therefore this is considered as a global problem and is now dealt with at a poitical level. Since no new classes of antimicrobial agents have been discovered in the past three deacdes, the development of new drugs is extremely urgent. Therefore the aim of this project was to synthesise derivatives of benzimidazole, and then assesses their antimicrobial activities in vitro by using disc (well) diffusion and MICs tests. A total of 69 benzimidazole derivatives, with substituents at positions

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24

Alasmary, Fatmah A. S. "Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents. An investigation into the synthesis of substituted benzimidazoles and their evaluation in vitro for antimicrobial activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6325.

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Microbe resistence is a serious issue, especially as they have become resistant to most well known drugs. Therefore this is considered as a global problem and is now dealt with at a poitical level. Since no new classes of antimicrobial agents have been discovered in the past three deacdes, the development of new drugs is extremely urgent. Therefore the aim of this project was to synthesise derivatives of benzimidazole, and then assesses their antimicrobial activities in vitro by using disc (well) diffusion and MICs tests. A total of 69 benzimidazole derivatives, with substituents at pos

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25

Azmus, Dora J. Taylor. "Synthesis of polybenzimidazoles from monomers containing flexible linkages." Thesis, Corvallis, Oregon : Oregon State University, 1992. http://handle.dtic.mil/100.2/ADA256976.

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Thesis (M.S.)--Oregon State University, 1993.<br>Description based on title screen as viewed on April 8, 2009. "Completed 13 May 1992, Commencement June 1993." Includes bibliographical references (p. 73-75). Also available in print.

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26

Ritchie, Michael W. "Benzimidazole nucleoside analogues as potential antiherpetic agents." Thesis, University of St Andrews, 1997. http://hdl.handle.net/10023/14245.

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27

Donaghy, Michael. "Studies in benzimidazo [2,1-a] isoquinoline chemistry." Thesis, Northumbria University, 2001. http://nrl.northumbria.ac.uk/1217/.

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Studies in Benzimidazo[2,1-a]isoquinoline Chemistry by Michael John Donaghy B. Sc. (Hons.) Ellipticine, a member of the pyrido[4,3-b]carbazole alkaloid family first isolated in 1959 from the leaves of the plant Ochrosia Elliptica has been shown to possess anti-cancer activity against various tumours. Ellipticine is thought to undergo biological oxidation to give the more active 9-hydroxyellipticine that is subsequently converted to a highly reactive quinone-imine intermediate. The quinone-imine is then thought to interact with bionucleophiles in the body promoting cell death. The aim of the pr

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28

White, Wade M. "Synthesis and photoluminescent properties of linear and starburst compounds based on benzimidazole, 2-(2'-pyridyl)benzimidazole and 2,2'-dipyridylamine." Thesis, Kingston, Ont. : [s.n.], 2007. http://hdl.handle.net/1974/495.

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29

Matthews, Craig J. "Metal extractants based on benzimidazoles." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297532.

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30

Barsys, Vygantas. "Benzimidazolų ir dihidropiridinų poveikio kraujagyslių segmentų ir papiliarinių raumenų izometrinei funkcijai įvertinimas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2013~D_20140106_083915-09957.

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Šio eksperimentinio darbo tikslas buvo įvertinti 1,4-dihidropiridino ir benzimidazolo junginių poveikį jūros kiaulyčių širdies papiliarinių raumenų izometrinei funkcijai bei žmogaus kraujagyslių segmentų susitraukimui ir atsipalaidavimui. Buvo atlikti eksperimentiniai tyrimai su izoliuotais jūros kiaulyčių širdies papiliarinių raumenų preparatais ir izoliuotais žmogaus v.saphena magna ir a.thoracica interna kraujagyslių segmentais. Kraujagyslių preparatai gauti iš pacientų, kuriems buvo atliekamos širdies vainikinių arterijų jungčių suformavimo operacijos LSMU ligoninės Kauno klinikos Kardioch

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Karim, Rehana. "Development of radical synthetic methodology using solid-phase organic synthesis." Thesis, Loughborough University, 2003. https://dspace.lboro.ac.uk/2134/34406.

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The synthesis of heterocycles using radical intermediates has become an important area of research in recent years. The aim of our research was to develop radical methodologies to construct heterocycles on solid-support. Tri-cyclic benzimidazole derivatives are desirable synthetic targets with a range of biological activity and are part of certain anti-tumour agents. Solid-supported radical reactions with substituted benzimidazoles were performed under different experimental conditions, including different solvents, three different resins (Wang, Merrifield and Rink) and different radical reage

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32

Akpinar, Hava Zekiye. "Synthesis Of Benzimidazole Containing Donor Acceptor Electrochromic Polymers." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613006/index.pdf.

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ABSTRACT SYNTHESIS OF BENZIMIDAZOLE CONTAINING DONOR ACCEPTOR ELECTROCHROMIC POLYMERS Akpinar, Hava Zekiye M. Sc., Department of Chemistry Supervisor: Prof. Dr. Levent Toppare February 2011, 60 pages Donor-acceptor-donor (DAD) type benzimidazole (BIm) and 3,4-ethylenedioxythiophene (EDOT) bearing monomers (4-(2,3-Dihydrothieno[3,4-b][1,4]dioxin-5-yl)-7-(2,3 dihydrothieno[3,4b][1,4] dioxin-7-yl)-2-benzyl-1H-benzo[d]imidazole (M1), 2,4-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-7-(2,3-dihydrothieno[3,4-b][1,4]dioxin-7-yl)-1H-benzo[d]imidazole (M2) and 4-(2,3-dihydrothieno[3,4-b][1

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33

Blakemore, Emily J. A. "Molecular genetics of benzimidazole resistance in Pseudocercosporella herpotrichoides." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276190.

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34

FARCI, PAMELA. "Identification and mode of action studies of new potent inhibitors of the RNA viruses HCV, BVDV and RSV." Doctoral thesis, Università degli Studi di Cagliari, 2012. http://hdl.handle.net/11584/266186.

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Several of worldwide emerging infections are caused by RNA viruses. For this reason, research in the antiviral chemotherapy field is directed toward the development of compounds that target various steps of the virus life cycle. In this work the antiviral activity of 5-Acetyl-2- Arylbenzimidazoles and 2-[(benzotriazol-1/2 yl)methyl]benzimidazoles has been evaluated against representatives of several virus families, including HCV BVDV, YFV, REO-1, CVB-5, Sb-1 and RSV. Some of the new derivatives turned out to be very interesting for their potency and selectivity against BVDV and HCV (the form

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35

Robinson, A. G. "Synthesis and reactions of 2H-benzimidazoles." Thesis, University of Salford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356186.

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36

Ozelcaglayan, Ali Can. "Synthesis Of Electroactive Benzimidazole Derivatives And Their Electrochromic Properties." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12615196/index.pdf.

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In order to study their electrochemical and optical properties, two donor-acceptordonor (D-A-D) type monomers<br>4&#039<br>-(tert-butyl)-4,7-bis(4-hexylthiophen-2- yl)spiro[benzo[d]imidazole-2,1&#039<br>-cyclohexane] (BIHT) and 4&#039<br>-(tert-butyl)-4,7-bis(2,3- dihydrothieno[3,4-b][1,4]dioxin-5-yl)spiro[benzo[d]imidazole-2,1&#039<br>-cyclohexane] (BIED), were electrochemically polymerized. These properties were investigated by cyclic voltammetry and UV&ndash<br>Vis-NIR Spectroscopy techniques. Effects of different donor groups<br>3-hexylthiophene and 3, 4-ethylenedioxythiophene (EDOT), on n

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37

Scott, Elspeth Warren. "Effects of benzimidazole anthelmintics on nematode parasites of sheep." Thesis, University of Glasgow, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284783.

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Bowles, Steven E. "Synthesis and characterization of annelated nitronyl nitroxides /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/11611.

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Van, Niekerk Xandri. "Rhenium complexes of benzazole derivatives." Thesis, Nelson Mandela Metropolitan University, 2017. http://hdl.handle.net/10948/21252.

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A series of rhenium(I) complexes with monodentate benzazole ligands containing the fac-[Re(CO)3]+ was synthesized. The rhenium(I) compound [ReCl(Hmbt)2(CO)3] was prepared from the reaction of [Re(CO)5Cl] and 2-aminobenzothiazole (Hmbt) in toluene. The ligand coordinates in a monodentate manner via the thiazole nitrogen atom. A similar reaction between [Re(CO)5Cl] and N-(1,3-benzothiazol-2-yl)-2- chloroacetamide (Hbct) resulted in the formation of [ReCl(Hbct)(CO)3(NCMe)], where only one ligand binds per rhenium in a monodentate fashion. The reaction of ligands 2-mercaptobenzimidazole (Hmbi) (di

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Ragunathan, Ramanaranjinie. "Studies of certain benzimidazoles, phthalazines and phthalimides." Thesis, Brunel University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292494.

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Wathey, William B. "The synthesis of benzimidazoles of medicinial interest." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329643.

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The aim of this programme was to design and synthesize triazinobenzimidazoles that are analogous to the antihypertensive agents, hydralazine and dihydralazine. Retrosynthetic analysis of these analogues showed that the key intermediates in the synthesis were the novel [1,2,4]triazino[4,5-a]benzimidazol-l-ones and the related 1,4-diones. Existing routes to this tricyclic ring system were either limited in scope or needed expensive starting materials. Therefore, a new synthetic route to these compounds was developed using the readily available 2-acylbenzimidazoles as starting materials. These ac

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Burford, Donald L. W. "Some studies with benzimidazoles and related heterocycles." Thesis, Loughborough University, 1988. https://dspace.lboro.ac.uk/2134/33065.

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The thesis reports the first examples of Reissert compounds prepared from the benzimidazole ring system; the first examples of monocyclic five-membered ring Reissert compounds; and an exploration of the chemistry of these compounds. The key procedure for their formation utilizes trimethylsilyl cyanide in a single-phase non-aqueous medium. Previous attempts to synthesize five-membered ring Reissert compounds have failed because, under the conventional two-phase conditions, the reaction either does not proceed or ring opening of the heterocycle occurs. The reactions of benzimidazole with an acid

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Clark, Hannah Jane. "The molecular mechanisms of benzimidazole resistance in equine small strongyles." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441739.

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Robinson, M. W. "Mechanisms of benzimidazole resistance in the liver fluke, Fasciola hepatica." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273381.

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Bong, Sze How. "The potential of Triclabendazole in combination with Praziquantel for the treatment of Schistosoma mansoni infections." Bong, Sze How (2007) The potential of Triclabendazole in combination with Praziquantel for the treatment of Schistosoma mansoni infections. PhD thesis, Murdoch University, 2007. http://researchrepository.murdoch.edu.au/1302/.

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Previous work has suggested that triclabendazole, a member of the benzimidazole group of compounds, possessed efficacy against Schistosoma mansoni. In view of recent indications in praziquantel treatment failures and loss of sensitivity, it is imperative that new anti-schistosomals are developed as contingent treatment options, while resistance alleles, if any, remain at low frequencies. While recent studies have indicated that triclabendazole monotherapy exert weak anti-schistosomal effects, the combinatorial application of triclabendazole with praziquantel has not been explored. To assess th

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N'Diaye, Ibrahima. "Annelation du benzimidazole : étude chimique et parasitologique des dérivés tricycliques et de leurs précurseurs." Paris 11, 1986. http://www.theses.fr/1986PA112140.

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Ce travail a été réalisé dans le but d'obtenir des dérivés tricycliques du benzimidazole susceptibles d'avoir une activité antiparasitaire. L'étude chimique est présentée en quatre chapitres. Le premier consiste en la synthèse de chloro-2 benzimidazoles substitués en 1 par une chaîne fonctionnalisée. Les homologues nitrés au noyau benzénique ont également été préparés en raison du caractère pharmacophore antiparasitaire de ce substituant. Les autres chapitres portent sur les réactions des nucléophiles azotés ou oxygénés avec les chloro-2 benzimidazoles substitués en 1. Des benzimidazoles subst

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Alaqeel, Shatha. "Synthesis of novel dimeric and oligomeric benzimidazoles targeted to nucleic acid minor groove binding." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-novel-dimeric-and-oligomeric-benzimidazoles-targeted-to-nucleic-acid-minor-groove-binding(5e5b7b9a-72fb-4941-80ec-0a28a3c1b098).html.

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Amido-oligopyrroles/imidazoles and dimeric benzimidazoles are heterocyclic compounds which are nucleic acid minor groove binding agents. The targets for this project were symmetrical and unsymmetrical amide-linked di- and tri- and tetrameric benzimidazoles to evaluate as potential DNA binding agents. Syntheses involved linkage between C2 and C5 positions of 2-carboxy, 5-carboxy or 2,5-dicarboxy and 2-amino, 5-amino or 2,5-diamino-bearing benzimidazoles. This matrix of substrates could be coupled directly C2-C5 by amide linkage, or these same precursors could also be dimerized symmetrically usi

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Hubbard, Jeremiah W. "Synthesis of substituted 2-vinyl and 2-phenylbenzimidazoles and progress towards the synthesis of natural products ht-13-A and ht-13-B." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=6051.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xi, 179 p. : ill. Includes abstract. Includes bibliographical references (p. 88-94).

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Dale, Aaron Grainger. "Elucidating the molecular target of symmetric bis-benzimidazoles." Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543260.

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Howells, Ian Robert. "Synthetic studies on 1H-azepines benzimidazoles and quinoxalines." Thesis, University of Salford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308171.

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