Relevant bibliographies by topics / Benzimidazoles – Synthesis

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Academic literature on the topic 'Benzimidazoles – Synthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Benzimidazoles – Synthesis"

1

Al-Warhi, Tarfah, Mohamed Said, Mahmoud El Hassab, Nada Aljaeed, Hazem Ghabour, Hadia Almahli, Wagdy Eldehna, and Hatem Abdel-Aziz. "Unexpected Synthesis, Single-Crystal X-ray Structure, Anticancer Activity, and Molecular Docking Studies of Certain 2–((Imidazole/Benzimidazol–2–yl)thio)–1–arylethanones." Crystals 10, no. 6 (May 31, 2020): 446. http://dx.doi.org/10.3390/cryst10060446.

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In connection with our research program concerning development of novel effective benzimidazole-based anticancer candidates, herein we describe a new unexpected synthetic route to obtain a series of 2–((imidazole/benzimidazol2–yl)thio)1–arylethanones endowed with promising anti-breast cancer and Cyclin-dependent kinase 2 (CDK2) inhibitory activities. Contrary to expectations, products for the reaction of 2–mercaptoimidazole/benzimidazole 2a,b with β–keto esters 6a–c were unambiguously assigned as 2–((imidazol/benzimidazol2–yl)thio)1–arylethanones 10a–f based on NMR spectroscopy and single-crystal X-ray crystallographic analyses. In vitro anticancer activities for herein reported imidazole/benzimidazoles 10a–f were assessed through a cell-based assay against human breast cancer T4–7D and MCF–7 cell lines. Benzimidazoles 10d–f exerted better anti-proliferative action towards T4–7D and MCF–7 cell lines than their corresponding imidazole counterparts 10a–c. Furthermore, a molecular docking study suggested CDK2 kinase as a potential enzymatic target for benzimidazoles 10d–f, and investigated their possible binding pattern and interactions within CDK2 active site. Thereafter, benzimidazoles 10d–f were in vitro examined for their CDK2 inhibitory action, where they exerted good activity. Finally, several key ADME and druglikeness properties were predicted by the SwissADME online tool. Interestingly, benzimidazoles 10d–f were found to have no violations in all druglikeness rules (Veber, Lipinski, Ghose, Muegge, and Egan). In addition, they had neither PAINS nor structural alerts (Brenks). In conclusion, benzimidazoles 10d–f demonstrated not only a promising anticancer activities but also an acceptable ADME and physicochemical properties especially benzimidazole 10e.
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Krishnamurthy, Naik, and Narashimaiah Shashikala. "Synthesis of ruthenium(II) carbonyl complexes with 2-monosubstituted and 1,2-disubstituted benzimidazoles." Journal of the Serbian Chemical Society 74, no. 10 (2009): 1085–96. http://dx.doi.org/10.2298/jsc0910085k.

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The reaction of the polymeric carbonyl complex [RuCl2(CO)2]x with 2-monosubstituted and 1,2-disubstituted benzimidazoles and 1,4-bis(benzimidazol- 2-yl)benzene (L9) in 2-methoxyethanol produces various coloured complexes of the formulae [Ru(CO)2Cl2(L)2]?xH2O (L = 1-(o-hydroxybenzyl)-2-(o-hydroxyphenyl)benzimidazole (L1), 1-(o-hydroxyphenyl)benzimidazole (L4), 1-(p-hydroxyphenyl)benzimidazole (L5), 1-(p-chlorobenzyl)-2-p-chlorophenyl) benzimidazole (L7), 1-[1-(dimethylamino)benzyl]-2-[1-(dimethylamino) phenyl]benzimidazole (L10), x = 0; L = 2-benzylbenzimidazole (L8), 1,4-bis(benzimidazol-2-yl)benzene (L9), x = 2; L = 1-(o-chlorobenzyl)-1-(o-chlorophenyl)benzimidazole (L6); x = 3), [Ru(CO)2Cl(L2)3]Cl?3H2O and [Ru(CO)2(L3)4]Cl2?3H2O (L2 = 1-(m-hydroxybenzyl)-2-(m-hydroxyphenyl)- benzimidazole; L3 = 1-(p-hydroxybenzyl)-2-(p-hydroxyphenyl)benzimidazole). The complexes were characterized by elemental analysis, conductivity measurements, as well as infrared, electronic, 1H- and 13C-NMR spectral studies.
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3

Sweeney, Martin, Darren Conboy, Styliana I. Mirallai, and Fawaz Aldabbagh. "Advances in the Synthesis of Ring-Fused Benzimidazoles and Imidazobenzimidazoles." Molecules 26, no. 9 (May 4, 2021): 2684. http://dx.doi.org/10.3390/molecules26092684.

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This review article provides a perspective on the synthesis of alicyclic and heterocyclic ring-fused benzimidazoles, imidazo[4,5-f]benzimidazoles, and imidazo[5,4-f]benzimidazoles. These heterocycles have a plethora of biological activities with the iminoquinone and quinone derivatives displaying potent bioreductive antitumor activity. Synthesis is categorized according to the cyclization reaction and mechanisms are detailed. Nitrobenzene reduction, cyclization of aryl amidines, lactams and isothiocyanates are described. Protocols include condensation, cross-dehydrogenative coupling with transition metal catalysis, annulation onto benzimidazole, often using CuI-catalysis, and radical cyclization with homolytic aromatic substitution. Many oxidative transformations are under metal-free conditions, including using thermal, photochemical, and electrochemical methods. Syntheses of diazole analogues of mitomycin C derivatives are described. Traditional oxidations of o-(cycloamino)anilines using peroxides in acid via the t-amino effect remain popular.
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4

Wang, Cheng Jun, De Yun Zeng, Shan Shan Gong, and Qi Sun. "An Unexpected Synthesis of 2H-Benzimidazole Derivatives." Advanced Materials Research 1023 (August 2014): 43–46. http://dx.doi.org/10.4028/www.scientific.net/amr.1023.43.

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Treatment of 1,2-phenylenediamines and 3-(N-phenyl-N-methyl) aminoacrolein with ZrCl4as catalyst in refluxing 95% ethanol afforded unexpected 2H-benzimidazole derivatives as the major products. It was determined that the formation of 2H-benzimidazoles was not from the decomposition of the 2-aminovinyl benzimidazoles.
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5

Begunov, Roman S., and Alexandr A. Sokolov. "SYNTHESIS AND MASS SPECTROMETRIC CHARACTERISTICS OF 1-(AMINOARYL)BENZIMIDAZOLES." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 63, no. 9 (August 3, 2020): 12–20. http://dx.doi.org/10.6060/ivkkt.20206309.6230.

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As a result of two-stage synthesis, a number of 1-(aminoaryl)benzimidazoles, potential biologically active substances, were obtained. During the first stage, an aromatic nucleophilic substitution reaction, 2-R-benzimidazoles reacted with halogen-nitroarenes. The process proceeded under mild conditions, this indicates a good nucleophilic properties of benzimidazole. It has been shown that during reduction, depending on the structure of 1-(nitroaryl)benzimidazoles in an acidic medium, in addition to the main process, acid-catalyzed isomerization can occur. Rearrangement was observed during the reduction of 1-(2-nitroaryl)benzimidazoles. The presence of a methyl group at the 2 position of the benzimidazole ring of these compounds hindered the rearrangement. When carrying out the reaction under conditions of heterogeneous catalysis in the reactor for flow hydrogenation, isomerization was also not observed. The use of 1-(4-nitroaryl)benzimidazoles as a substrate resulted in the formation of only one product. The mass spectral characteristics of 1-(aminoaryl)benzimidazoles were studied. The peak attribution of the molecular ion [M]+ was carried out by recording mass spectra with electrospray ionization. Ways of fragmentation of the molecular ion of these compounds under the influence of electron impact are proposed. Characteristic ions are identified. It was established that the fragmentation of the molecular ion of 1-(aminoaryl)benzimidazoles began either by elimination of the substituents, followed by cleavage of the two C—N bonds in imidazole, or by elimination of the HCN fragment of the imidazole ring and further elimination of the substituents. As a result, the formation of the cation radical of N-phenylbenzenediamine with m/z 181 was occurred. The fragmentation of this ion was carried out similarly to aromatic amines via elimination of a neutral HCN molecule. Further decay of alkylarylamine ions led to a group of characteristic fragmentation ions. Thus, mass spectrometry can be effectively used to identify N-aryl substituted benzimidazoles, as well as their decomposition products.
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6

Andric, Deana, Gordana Tovilovic, Goran Roglic, Djurdjica Vaskovic, Vukic Soskic, Mirko Tomic, and Sladjana Kostic-Rajacic. "Synthesis and pharmacological evaluation of several N-(2-nitrophenyl) piperazine derivatives." Journal of the Serbian Chemical Society 72, no. 5 (2007): 429–35. http://dx.doi.org/10.2298/jsc0705429a.

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Six newly synthesized heterocyclic (2-nitrophenyl)piperazines, with a specific structure of the heteroaryl group, whichmimics the catechol moiety of dopamine (benzimidazoles and substituted benzimidazoles), were evaluated for their binding affinity to rat dopamine (DA), serotonin (5-HT) and _1 receptors. All compounds with a benzimidazole group had a 5-HT2A/D2 receptors binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 7c, 4-bromo-6-{2-_4-(2-nitrophenyl)piperazin- 1-yl_ethyl}-1H-benzimidazole, expressed higher affinities for all receptor classes than clozapine. Also, it exhibited the best characteristic for atypical neuroleptics and presents a compound with the best profile for further in vivo investigations.
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Bektas, Hakan, Canan Albay, Emre Menteşe, Bahar Bilgin Sokmen, Zafer Kurt, and Dilem Şen. "Synthesis, Antioxidant and Antiurease Activities of Some New 5,6- dichloro-2-(4-fluorobenzyl)-1H-benzimidazole Derivatives Containing Furan, Oxadiazole, Triazole and Thiadiazole Moieties." Letters in Drug Design & Discovery 16, no. 8 (August 8, 2019): 939–47. http://dx.doi.org/10.2174/1570180815666180827124956.

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Background:Benzimidazoles and its derivatives have been attracting interest for many years because of their biological activities. Benzimidazoles containing different heterocyclic moieties have wide range of biological activities such as antimicrobial, antioxidant, anticancer, antiviral, etc.Methods:In this study, some benzimidazole derivatives containing furan, oxadiazole, triazole and thiadiazole moieties have been synthesized and then evaluated for their antioxidant and antiurease activities.Results:The results showed that all the tested benzimidazoles indicated remarkable urease inhibitory potentials with IC50 values ranging between 0.303±0.03 to 0.591±0.08 µM.Conclusion:In conclusion, synthesized benzimidazole derivatives showed good antioxidant and antiurease activities. Heterocyclic groups on benzimidazole nucleus enhance the activities.
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8

Barasa, Leonard, Hari P. Vemana, Nirupama Surubhotla, Sin S. Ha, Jing Kong, Alison Yong, John L. Croft, Vikas V. Dukhande, and Sabesan Yoganathan. "Synthesis and Biological Evaluation of Structurally Diverse Benzimidazole Scaffolds as Potential Chemotherapeutic Agents." Anti-Cancer Agents in Medicinal Chemistry 20, no. 3 (April 24, 2020): 301–14. http://dx.doi.org/10.2174/1871520619666191028101506.

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Background and Objective : Drug resistance and adverse effects are immense healthcare challenges in cancer therapy. Benzimidazole ring-based small molecules have been effective anticancer agents in drug development. In an effort to develop novel chemotherapeutics, we synthesized and assessed the anticancer and antibacterial activities of a small library of structurally unique benzimidazoles. Methods : The benzimidazoles were derived from indole, N-alkyl indole, fatty acid, and alpha-amino acid scaffolds providing a panel of diverse structures. The compounds were tested in three different cancer cell lines for cytotoxicity: HepG2 (human hepatocellular carcinoma), HeLa (human cervical carcinoma), and A549 (human lung carcinoma). Mechanism of cell death induced by benzimidazoles was evaluated using fluorescent dye-based apoptosis-necrosis assay, immunoblotting for active caspases, topoisomerase-II activity assay, and cell cycle assay. Results : Cell viability testing revealed that indole- and fatty acid-based benzimidazoles were most potent followed by the amino acid derivatives. Many compounds induced cytotoxicity in a concentration-dependent manner with cellular cytotoxicity (CC50) <20μM in the cell lines tested. Most compounds exhibited cytotoxicity via apoptosis through the intrinsic pathway. Inhibition of topoisomerase activity and cell cycle alterations were not the primary mechanisms of cytotoxicity. In addition, several compounds showed promising activity against S. aureus and S. epidermidis (Minimum Inhibitory Concentration (MIC) of as low as 0.04μmol/mL). Conclusion: The reported benzimidazole derivatives possess promising anticancer and antibacterial properties. Additionally, we discovered apoptosis to be the primary mechanism for cancer cell death induced by the tested benzimidazoles. Our findings suggest that further development of these scaffolds could provide drug leads towards new chemotherapeutics.
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9

Kapoor, Kamal, Parthasarathi Das, Rajni Khajuria, Sk Rasheed, and Chhavi Khajuria. "Recent Developments in the Synthesis of Pyrido[1,2-a]benzimidazoles." Synthesis 50, no. 11 (April 24, 2018): 2131–49. http://dx.doi.org/10.1055/s-0036-1589533.

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Pyrido[1,2-a]benzimidazole is one of the most important azaheterocyclic compounds consisting of three fused aromatic rings. Molecules containing this core have displayed a wide range of applications in the field of medicinal chemistry. The synthesis of pyrido[1,2-a]benzimidazole and its derivatives has attracted organic chemists because of its tremendous utility in interdisciplinary branches of chemistry. In this context, this review discusses the main advances in the synthesis of pyrido[1,2-a]benzimidazoles via metal-mediated and metal-free reactions from 2000 to 2016.1 Introduction2 Synthetic Approaches to Pyrido[1,2-a]benzimidazoles2.1 Type I: Transition-Metal-Catalyzed Methods2.2 Type II: Metal-Free Approaches3 Conclusion
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Ibrahim, Hassan K., Sayed H. El-Tamany, Reda F. El-Shaarawy, and Ibrahim M. El-Deen. "Synthesis and investigation of mass spectra of some novel benzimidazole derivatives." Macedonian Journal of Chemistry and Chemical Engineering 27, no. 1 (June 15, 2008): 65. http://dx.doi.org/10.20450/mjcce.2008.248.

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2-Substituted benzimidazoles (3) and (4a-c) were prepared via condensation of ethyl 2-thionyl-pyruvate (1) and hydrazidoyl derivatives (2a-c) with o-phenylene diamine in acetic acid. Acetylation of compound (4a) with acetic anhydride yielded the corresponding N-acetyl derivative (5). Treatment of compound 4b with hydrazine hydrate gave the corresponding hydrazino derivative (6). Reaction of 2-[(2-thionyl)acetyl)] benzimidazole (3) with hydrazine hydrate gave the pyrazolyl derivative (7) and hydrazino derivative (8). Alkylation of compound 3 with alkyl halide gave the corresponding 2,3-disubstituled benzimidazoles (9a, b). Pyrrolo[1,2-a] benzimidazole derivatives 10 and 11 were prepared via cyclocondensation of compound 3 with acetic anhydride in presence of AcONa and phosphorus oxychloride. The electron impact mass spectra of both of the above series of compounds have also been recorded and their fragmentation patterns are discussed.
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Dissertations / Theses on the topic "Benzimidazoles – Synthesis"

1

Azmus, Dora J. Taylor. "Synthesis of polybenzimidazoles from monomers containing flexible linkages." Thesis, Corvallis, Oregon : Oregon State University, 1992. http://handle.dtic.mil/100.2/ADA256976.

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Thesis (M.S.)--Oregon State University, 1993.
Description based on title screen as viewed on April 8, 2009. "Completed 13 May 1992, Commencement June 1993." Includes bibliographical references (p. 73-75). Also available in print.
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2

Robinson, A. G. "Synthesis and reactions of 2H-benzimidazoles." Thesis, University of Salford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356186.

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Wathey, William B. "The synthesis of benzimidazoles of medicinial interest." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329643.

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The aim of this programme was to design and synthesize triazinobenzimidazoles that are analogous to the antihypertensive agents, hydralazine and dihydralazine. Retrosynthetic analysis of these analogues showed that the key intermediates in the synthesis were the novel [1,2,4]triazino[4,5-a]benzimidazol-l-ones and the related 1,4-diones. Existing routes to this tricyclic ring system were either limited in scope or needed expensive starting materials. Therefore, a new synthetic route to these compounds was developed using the readily available 2-acylbenzimidazoles as starting materials. These acyl derivatives were converted to hydrazones, ethoxycarbonylhydrazones and benzimidazole-2-carboxylic acid ethoxycarbonylhydrazides. The substituted hydrazines were cyclized to the desired tricyclic lactam intermediates either thermally, or acylatively using ethyl chloroformate in pyridine. The versatility of these cyclization methods has been demonstrated by the synthesis of a variety of novel N-2 substituted [1,2,4]triazino[4,5-a]benzimidazol- 1-ones which may or may not have a substituent at C-4. In addition, it has been shown that these types of cyclizations provide a better route to existing triazinobenzimidazoles. Although attempts to chlorinate or thiate these lactams were unsuccessful, use of the dithio analogue of ethyl carbazate, methyl dithiocarbazate, afforded sulphur-containing hydrazones which were cyclized to the desired [1,2,4]triazino[4,5-a]benzimi dazole-1-thiones. Displacement of the enolized 1-thione by hydrazine produced the desired target molecules, 1-hydrazino- [1,2,4]triazino[4,5-a]benzimidazoles. In preliminary screening, these compounds exhibited in vivo vasodilatory activity. In an attempt to vary the 4-substituent of the tricyclic system further, the synthesis of a variety of modified 2-acylbenzimidazoles was undertaken. In particular, the structure and reactions of one of these modified ketones, 2-bromoacetylbenzimidazole, was investigated in an attempt to explain its bromination pattern. Other workers have suggested that the unusual bromination pattern of 2-acetyl and 2-bromoacetylbenzimidazole may arise from the influence of intramolecular hydrogen bonding between the imine proton and the carbonyl group. However, a computer-aided reinvestigation of this reaction has shown that a more plausible intermediate is an intramolecularly hydrogen bonded enol of the ketone. The synthesis of two novel triazepinobenzimidazole ring systems has been examined. The acylative-cyclization (ethyl chloroformate-pyridine) developed for the preparation of the novel triazines has been extended to the synthesis of the hitherto unknown [1,2,4]triazepino[4,5-a]benzimidazole ring system. A series of new 1,2-diacylbenzimidazoles were prepared as precursors to [1,2,5]triazepino[5,4-a]benzimidazoles. However, attempts to add hydrazine across the dicarbonyl groups gave only novel benzimidazole hydrazine or hydrazide derivatives instead of the desired triazepinobenzimidazoles. Many of the compounds described in this thesis have been screened for possible pharmacological activity.
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Bowles, Steven E. "Synthesis and characterization of annelated nitronyl nitroxides /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/11611.

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Taylor, S. L. "An investigation of catalysis in the Ladenburg synthesis of benzimidazoles." Thesis, Manchester Metropolitan University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233017.

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Wahedy, Kanan Mahmoud. "Methodology for synthesis of novel bis-and oligo (benzimidazoles)." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684999.

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Hubbard, Jeremiah W. "Synthesis of substituted 2-vinyl and 2-phenylbenzimidazoles and progress towards the synthesis of natural products ht-13-A and ht-13-B." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=6051.

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Thesis (Ph. D.)--West Virginia University, 2008.
Title from document title page. Document formatted into pages; contains xi, 179 p. : ill. Includes abstract. Includes bibliographical references (p. 88-94).
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8

Hazelton, J. C. "Reactions of 2H-benzimidazoles and synthesis of some potential anthelmintics." Thesis, University of Salford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234629.

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9

Khan, Aqeel Ahmad. "Synthesis of novel oligomeric bis-benzimidazoles for their biological evaluation." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-novel-oligomeric-bisbenzimidazoles-for-their-biological-evaluation(769832e2-2892-4bcb-b739-8929b4da5ca8).html.

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Benzimidazoles are heterocyclic compounds. Symmetrical and unsymmetrical benzimidazoles/oligomers are minor groove DNA sequence selective binding compounds. Distamycin A and netropsin are examples of naturally occurring DNA binders. Hoechst 33258 (Bis–benzimidazole) is a synthetic minor groove A-T sequence selective reagent and has in vivo activity by inhibiting the topoisomerase II enzyme. The targets in this research work were to synthesise extended analogues of Hoechst with structural modifications (amide bond) or amide-linked dimers with a view to identifying new potential ligands. To synthesise a library of novel bis-benzimidazoles (analogues of Hoechst) several methods were used. For C5–C2 direct linkage aldehyde synthesis via ester, Weinreb amide reduction, condensation of acids with diamine by Eaton’s reagent were applied. Cyclization of amide-linked benzimidazoles (amide bond between carboxylic acid of C5 benzimidazole and diamine), an indirect method of bis-benzimidazole synthesis was also used to prepare a library of novel bis-benzimidazoles giving a series of novel intermediates. Higher molecular weight oligomeric structures (Linked by amide bond either between C5-C5 or C5-C2) were prepared by using (EDCI / HOBt) or (HBTU / DIPEA). A library of novel amide-linked, oligomeric analogues of Hoechst were also synthesised by coupling bis-benzimidazole building blocks bearing reactive groups at positions 2 or 5. Amine (by the reduction of a nitro precursor) or carboxylic acid (from ester hydrolysis) was coupled with monomeric amino or carboxylic acid benzimidazole derivatives using different peptide coupling reagents. Further structural modifications were performed either by reduction of an ester on a bis-benzimidazole or by the reaction of hydrazine with the ester or acid to have an additional flexible spacer (amide bond) with reactive amine to address the issue of solubility. SPR (Surface Plasmon Resonance) was employed to evaluate more than 30 different analogues in comparison with Hoechst 33258 in terms of their DNA binding affinity using three different oligonucleotides having A2T2, A3T3, A4T4 sequences. The data revealed that compounds with charged specie at peripheral groups are better binders in the grooves of DNA.
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Alaqeel, Shatha. "Synthesis of novel dimeric and oligomeric benzimidazoles targeted to nucleic acid minor groove binding." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-novel-dimeric-and-oligomeric-benzimidazoles-targeted-to-nucleic-acid-minor-groove-binding(5e5b7b9a-72fb-4941-80ec-0a28a3c1b098).html.

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Amido-oligopyrroles/imidazoles and dimeric benzimidazoles are heterocyclic compounds which are nucleic acid minor groove binding agents. The targets for this project were symmetrical and unsymmetrical amide-linked di- and tri- and tetrameric benzimidazoles to evaluate as potential DNA binding agents. Syntheses involved linkage between C2 and C5 positions of 2-carboxy, 5-carboxy or 2,5-dicarboxy and 2-amino, 5-amino or 2,5-diamino-bearing benzimidazoles. This matrix of substrates could be coupled directly C2-C5 by amide linkage, or these same precursors could also be dimerized symmetrically using small bifunctional linkers (diamine or diacid), affording symmetrical C2-C2 or C5-C5 dimer types of orientation, such as head-to- head, and tail-to tail systems. Monomeric building block benzimidazoles were prepared by condensation of o- phenylene diamines with either aldehydes or carboxylic acids affording the corresponding C2 or C5 amino and C5 carboxybenzimidazoles. 2- Carboxybenzimidazoles were however prepared by condensation of o-phenylene diamines with trichloroacetimidate followed by hydrolysis. New different novel symmetrical and unsymmetrical-bis(benzimidazole) libraries (C2-C2, C5-C5 and C5- C2 orientation) were prepared via coupling of different aminobenzimidazoles with different carboxybenzimidazoles from the matrix of available monomers. Novel tris(benzimidazoles) with differently linked orientations were prepared either by coupling one equivalent of 2,5-dicarboxybenzimidazole with two equivalents of aminobenzimidazole or coupling one equivalent of 2,5-diaminobenzimidazole with two equivalents of carboxybenzimidazole. A second set of novel tris(benzimidazoles) was prepared via reduction of a nitro- to amino bearing dimer followed by coupling with another carboxybenzimidazole monomer. Novel symmetrical tetra(benzimidazoles) (C2-C2-C2-C2 and C5-C2-C2-C5 orientation) were synthesized via either coupling one equivalent 2-dicarboxy dimeric benzimidazole with two equivalents of 2 or 5-aminobenzimidazole or via coupling one equivalent of 2-diaminobis(benzimidazole) with two equivalents of 2 or 5- carboxybenzimidazoles. Novel symmetrical bis(benzimidazoles) piperidine derivatives were synthesized via coupling one equivalent of 2-dicarboxy dimericbenzimidazole with two equivalents of piperidine derivatives. Forty oligomeric benzimidazoles were evaluated using Surface Plasmon Resonance (SPR) for binding to a series of three oligonucleotides containing A2T2, or A3T3 or A4T4 sequences. Data are presented showing the identification of four optimum ligands from a screen of 40, primarily 2L2552L2 tetramers but also several 2L5 dimers and dimeric 5,5-units without terminal additional benzimidazoles.
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Books on the topic "Benzimidazoles – Synthesis"

1

Moon, Denise. Synthesis of fluorinated imidazoles and benzimidazoles. Birmingham: University of Birmingham, 1987.

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Grimmett, M. R. Imidazole and benzimidazole synthesis. London: Academic Press, 1997.

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Hazelton, Justine Charlotte. Reactions of 2H-Benzimidazoles and synthesis of some potential anthelmintics. Salford: Universityof Salford, 1989.

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Howells, Ian Robert. Synthetic studies on 1H-azepines benzimidazoles and quinoxalines. Salford: University of Salford, 1996.

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Clark, Carol Margaret. Syntheses and reactions of 2H-benzimidazoles and their N-oxides. Salford: University of Salford, 1987.

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Azmus, Dora J. Taylor. Synthesis of polybenzimidazoles from monomers containing flexible linkages. 1992.

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Cook, Diana Lynn. Synthesis of polybenzimidazoles containing arylene sulfone and ether linkages. 1993.

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Imidazole and Benzimidazole Synthesis. Elsevier, 1997. http://dx.doi.org/10.1016/b978-0-12-303190-7.x5012-2.

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Book chapters on the topic "Benzimidazoles – Synthesis"

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Sreerama, R., and C. Kaushik. "In Silico Drug Design, Molecular Modelling, Synthesis and Characterization of Novel Benzimidazoles." In Special Publications, 271–87. Cambridge: Royal Society of Chemistry, 2019. http://dx.doi.org/10.1039/9781839160783-00271.

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Shaw, Gordon. "The Synthesis and Chemistry of Imidazole and Benzimidazole Nucleosides and Nucleotides." In Chemistry of Nucleosides and Nucleotides, 263–420. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4757-9667-4_4.

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Deepa, R., M. S. Lakshmi, P. Parasuraman, and C. F. Sharon. "Design, Molecular Docking, Synthesis and Anti-fungal Activity of Novel Benzimidazole Derivatives." In Special Publications, 108–11. Cambridge: Royal Society of Chemistry, 2019. http://dx.doi.org/10.1039/9781839160783-00108.

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Mamedov, Vakhid A. "Rearrangements of Quinoxalin(on)es for the Synthesis of Benzimidazol(on)es." In Quinoxalines, 343–422. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-29773-6_6.

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Unger, Thomas A. "Benzimidazoles." In Pesticide Synthesis Handbook, 410–11. Elsevier, 1996. http://dx.doi.org/10.1016/b978-081551401-5.50326-9.

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Grimmett, M. Ross. "Synthesis of Specifically Substituted Imidazoles and Benzimidazoles." In Imidazole and Benzimidazole Synthesis, 227–48. Elsevier, 1997. http://dx.doi.org/10.1016/b978-012303190-7/50021-2.

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Kamanna, Kantharaju. "Synthesis and Pharmacological Profile of Benzimidazoles." In Chemistry and Applications of Benzimidazole and its Derivatives. IntechOpen, 2019. http://dx.doi.org/10.5772/intechopen.85229.

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Basu, Basudeb, and Bablee Mandal. "Sustainable Synthesis of Benzimidazoles, Quinoxalines, and Congeners." In Green Synthetic Approaches for Biologically Relevant Heterocycles, 209–56. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-800070-0.00009-8.

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Rewcastle, Gordon W., William A. Denny, Ellen M. Dobrusin, and Daniel F. Ortwine. "Unequivocal Synthesis of 6- and 7-Substituted Thiazolo[3,2-a]benzimidazoles." In 19th International Congress on Heterocyclic Chemistry, 296. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-08-044304-1.50288-4.

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Boddapati, S. N. Murthy, Ramana Tamminana, Ravi Kumar Gollapudi, Sharmila Nurbasha, Mohamed E. Assal, Osamah Alduhaish, Mohammed Rafiq H. Siddiqui, Hari Babu Bollikolla, and Syed Farooq Adil. "Recent Study on Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles." In Current Advances in Chemistry and Biochemistry Vol. 3, 87–100. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/cacb/v3/7826d.

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Conference papers on the topic "Benzimidazoles – Synthesis"

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Cahyana, A. H., B. Ardiansah, and N. A. Asrianti. "Fe3O4 nanoparticles: An efficient and recyclable catalyst for benzimidazoles synthesis." In PROCEEDINGS OF THE 3RD INTERNATIONAL SYMPOSIUM ON CURRENT PROGRESS IN MATHEMATICS AND SCIENCES 2017 (ISCPMS2017). Author(s), 2018. http://dx.doi.org/10.1063/1.5064058.

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Raposo, M. Manuela, Rosa Batista, and Susana Costa. "Novel bithienyl-benzimidazoles: one-pot synthesis and optical and solvatochromic studies." In The 21st International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04742.

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Borade, Ravikumar M., Pavan R. Shinde, Swati B. Kale, and Rajendra P. Pawar. "Preparation, characterization and catalytic application of CoFe2O4 nanoparticles in the synthesis of benzimidazoles." In 2ND INTERNATIONAL CONFERENCE ON CONDENSED MATTER AND APPLIED PHYSICS (ICC 2017). Author(s), 2018. http://dx.doi.org/10.1063/1.5032529.

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Ghafuri, Hossein, Elahe Esmaili, and Majid Talebi. "Synthesis and Characterizationof Core-ShellFe3O4@Collagen Nanoparticle, and Application as Catalyst Ingreen Synthesis of Benzimidazoles and Benzithiazoles." In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-a032.

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Dolzhenko, Anton, Anna Dolzhenko, and Wai-Keung Chui. "Synthesis and Dihydrofolate Reductase Inhibitory Activity of 2-amino-[1,3,5]triazino[1,2-a]benzimidazoles." In The 9th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2005. http://dx.doi.org/10.3390/ecsoc-9-01515.

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Pino-Gonzalez, M. Soledad, and Inmaculada Martin-Torres. "Benzimidazoles from D-glucose derivatives." In The 20th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a066.

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Dekamin, Mohammad, Atefeh Nezamabadi, and Zahra Alirezvani. "1,3,5-Tris (2-hydroxyethyl) isocyanurate-Cu II functionalized magnetic graphene oxide (MGO-THEIC-CuII): a highly efficient and recoverable nanocatalyst for the one-pot synthesis of substituted benzimidazoles under microwave irradiation." In The 21st International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-05066.

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Kharche, Ajay, Sandeep Waghulde, Nilesh Gorde, and Mohan Kale. "MICROWAVE ASSISTED SYNTHESIS OF 2-ARYL BENZIMIDAZOLE." In The 24th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/ecsoc-24-08475.

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Romero-Parra, J., C. F. Lagos, C. Espinosa-Bustos, J. Mella-Raipán, C. D. Pessoa-Mahana, and Recabarren G. "Synthesis and docking of new benzimidazole derivates designed as novel and potent CB1 cannabinoid ligands." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0171-1.

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G. Costa, Susana P., Cátia Esteves, and M. Manuela M. Raposo. "Recognition of transition metals by benzimidazoles with an optical response." In The 19th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-d003.

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Reports on the topic "Benzimidazoles – Synthesis"

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Su, Ning, Jerald S. Bradshaw, Xian X. Zhang, Paul B. Savage, and Krzystof E. Krakowiak. Syntheses of Diaza-18-Crown-6 Ligands Containing Two Units Each of 4-Hydroxyazobenzene, Benzimidazole, Uracil, Anthraquinone, or Ferrocene Groups. Fort Belvoir, VA: Defense Technical Information Center, April 1999. http://dx.doi.org/10.21236/ada361715.

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