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Dissertations / Theses on the topic 'Benzimidazoles – Synthesis'

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Published: 4 June 2021
Last updated: 1 February 2022

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1

Azmus, Dora J. Taylor. "Synthesis of polybenzimidazoles from monomers containing flexible linkages." Thesis, Corvallis, Oregon : Oregon State University, 1992. http://handle.dtic.mil/100.2/ADA256976.

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Thesis (M.S.)--Oregon State University, 1993.<br>Description based on title screen as viewed on April 8, 2009. "Completed 13 May 1992, Commencement June 1993." Includes bibliographical references (p. 73-75). Also available in print.
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2

Robinson, A. G. "Synthesis and reactions of 2H-benzimidazoles." Thesis, University of Salford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356186.

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3

Wathey, William B. "The synthesis of benzimidazoles of medicinial interest." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329643.

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The aim of this programme was to design and synthesize triazinobenzimidazoles that are analogous to the antihypertensive agents, hydralazine and dihydralazine. Retrosynthetic analysis of these analogues showed that the key intermediates in the synthesis were the novel [1,2,4]triazino[4,5-a]benzimidazol-l-ones and the related 1,4-diones. Existing routes to this tricyclic ring system were either limited in scope or needed expensive starting materials. Therefore, a new synthetic route to these compounds was developed using the readily available 2-acylbenzimidazoles as starting materials. These ac
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4

Bowles, Steven E. "Synthesis and characterization of annelated nitronyl nitroxides /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/11611.

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5

Taylor, S. L. "An investigation of catalysis in the Ladenburg synthesis of benzimidazoles." Thesis, Manchester Metropolitan University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233017.

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6

Wahedy, Kanan Mahmoud. "Methodology for synthesis of novel bis-and oligo (benzimidazoles)." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684999.

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7

Hubbard, Jeremiah W. "Synthesis of substituted 2-vinyl and 2-phenylbenzimidazoles and progress towards the synthesis of natural products ht-13-A and ht-13-B." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=6051.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xi, 179 p. : ill. Includes abstract. Includes bibliographical references (p. 88-94).
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8

Hazelton, J. C. "Reactions of 2H-benzimidazoles and synthesis of some potential anthelmintics." Thesis, University of Salford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234629.

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9

Khan, Aqeel Ahmad. "Synthesis of novel oligomeric bis-benzimidazoles for their biological evaluation." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-novel-oligomeric-bisbenzimidazoles-for-their-biological-evaluation(769832e2-2892-4bcb-b739-8929b4da5ca8).html.

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Benzimidazoles are heterocyclic compounds. Symmetrical and unsymmetrical benzimidazoles/oligomers are minor groove DNA sequence selective binding compounds. Distamycin A and netropsin are examples of naturally occurring DNA binders. Hoechst 33258 (Bis–benzimidazole) is a synthetic minor groove A-T sequence selective reagent and has in vivo activity by inhibiting the topoisomerase II enzyme. The targets in this research work were to synthesise extended analogues of Hoechst with structural modifications (amide bond) or amide-linked dimers with a view to identifying new potential ligands. To synt
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10

Alaqeel, Shatha. "Synthesis of novel dimeric and oligomeric benzimidazoles targeted to nucleic acid minor groove binding." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-of-novel-dimeric-and-oligomeric-benzimidazoles-targeted-to-nucleic-acid-minor-groove-binding(5e5b7b9a-72fb-4941-80ec-0a28a3c1b098).html.

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Amido-oligopyrroles/imidazoles and dimeric benzimidazoles are heterocyclic compounds which are nucleic acid minor groove binding agents. The targets for this project were symmetrical and unsymmetrical amide-linked di- and tri- and tetrameric benzimidazoles to evaluate as potential DNA binding agents. Syntheses involved linkage between C2 and C5 positions of 2-carboxy, 5-carboxy or 2,5-dicarboxy and 2-amino, 5-amino or 2,5-diamino-bearing benzimidazoles. This matrix of substrates could be coupled directly C2-C5 by amide linkage, or these same precursors could also be dimerized symmetrically usi
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11

R, Aunós Clàudia [Verfasser]. "Synthesis and Biological Investigation of Antifungal Peptides and Benzimidazoles / Clàudia R. Aunós." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1227963041/34.

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12

Barnard, Linley Nicole. "Synthesis and profiling of antimalarial side-chain modified pyrido[1,2-a]benzimidazoles." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27245.

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The currently available malaria drugs in the market are unsatisfactory in many respects. Shortcomings include costly treatments, toxicity and various side effects. The rapid rise of resistant strains of Plasmodium falciparum, particularly in South-East Asia, has rendered even the most promising treatment regimens ineffective. Therefore, there is an urgent need to explore and develop new antimalarial drugs preferably with novel mechanisms of action, multistage activity, good safety profiles and efficacy at low doses. To address this need, structure activity relationship (SAR) and structure prop
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13

Alasmary, Fatmah Ali Saeed. "Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents : an investigation into the synthesis of substituted benzimidazoles and their evaluation in vitro for antimicrobial activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6325.

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Microbe resistence is a serious issue, especially as they have become resistant to most well known drugs. Therefore this is considered as a global problem and is now dealt with at a poitical level. Since no new classes of antimicrobial agents have been discovered in the past three deacdes, the development of new drugs is extremely urgent. Therefore the aim of this project was to synthesise derivatives of benzimidazole, and then assesses their antimicrobial activities in vitro by using disc (well) diffusion and MICs tests. A total of 69 benzimidazole derivatives, with substituents at positions
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14

Alasmary, Fatmah A. S. "Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents. An investigation into the synthesis of substituted benzimidazoles and their evaluation in vitro for antimicrobial activity." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/6325.

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Microbe resistence is a serious issue, especially as they have become resistant to most well known drugs. Therefore this is considered as a global problem and is now dealt with at a poitical level. Since no new classes of antimicrobial agents have been discovered in the past three deacdes, the development of new drugs is extremely urgent. Therefore the aim of this project was to synthesise derivatives of benzimidazole, and then assesses their antimicrobial activities in vitro by using disc (well) diffusion and MICs tests. A total of 69 benzimidazole derivatives, with substituents at pos
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15

Kim, Young Jun. "Kinetic and mechanistic investigations of polyimide formation and characterization of their blends with polybenzimidazoles." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/37417.

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This dissertation describes kinetic and mechanistic studies of high performance polyimide formation, synthesis and characterization of fully cyclized, molecular weight and end group controlled polyimides, and investigations of high performance polymer blends based upon polyimides and polybenzimidazole. Imidization kinetics were successfully followed by the quantitative non-aqueous titration of the amic acid functional groups as a function of reaction conditions. The homogeneous solution imidization processes were described by auto-acid catalyzed second order kinetics. The effects of heteroa
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16

Martin, Alex D. "A Convergent Approach to the Continuous Synthesis of Telmisartan via a Suzuki Reaction between Two Functionalized Benzimidazoles." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3750.

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A direct and highly efficient synthesis has been developed for telmisartan, the active ingredient in the widely prescribed antihypertensive drug Micardis®. This approach brings together two functionalized benzimidazoles using a high-yielding Suzuki reaction that can be catalyzed by a homogeneous palladium source or palladium on a solid support. The ability to perform the cross-coupling reaction was facilitated by the regio-controlled preparation of a 2-bromo-1-methylbenzimidazole precursor. The method developed is the first reported selective bromination at the 2-position of a benzimidazole an
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17

R, Aunós Clàudia [Verfasser], and Karl-Heinz [Akademischer Betreuer] Wiesmüller. "Synthesis and biological investigation of antifungal peptides and benzimidazoles / Clàudia R. Aunós ; Betreuer: Karl-Heinz Wiesmüller." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1200916190/34.

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18

Welsh, Athi. "Synthesis and biological evaluation of trimeric 2,5-disubstituted benzimidazoles and related trinuclear ruthenium(II) organometallic complexes." Master's thesis, Faculty of Science, 2019. https://hdl.handle.net/11427/31693.

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Cancer remains a global epidemic, with millions affected by the Non-Communicable Disease (NCD) annually. While cisplatin and its platinum(II) derivatives remain widely used chemotherapeutic agents, the undesirable side effects associated with the use of these metallodrugs and the evolution of resistance by cancers limit the scope of use of these platinum(II) complexes. Working towards addressing these issues, research has focused on the development of chemotherapeutic agents based on alternate platinum-group metals (PGMs), with ruthenium metallodrugs being among the most successful in this cat
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19

Nsanzubuhoro, Consolata Nsanzimpaka. "Piperazine-based pyrido[1,2-a]benzimidazoles: synthesis and pharmacological evaluation as potential antimalarial and antischistosomal agents." Master's thesis, Faculty of Science, 2018. http://hdl.handle.net/11427/30112.

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The emergence and spread of parasites resistant to first-line antimalarial drugs comprising artemisinin combination therapies (ACTs) threaten malaria control. There is therefore a need to develop novel and chemically diverse alternatives that are safe, efficacious, and able to circumvent drug resistance. Schistosomiasis is the second most prevalent tropical disease in the world after malaria, and treatment relies on a single drug: praziquantel. Although praziquantel shows multiple benefits over drugs previously used to treat schistosomiasis, dependence on it will result in therapeutic limitati
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20

Chisanga, Kelly. "Synthesis, structure-activity relationship and solubility improvement studies of potential antimalarial and antischistosomal pyrido[1,2-a]benzimidazoles." Master's thesis, Faculty of Science, 2019. http://hdl.handle.net/11427/31534.

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In 2016, 216 million malaria cases with 445,000 associated deaths were recorded according to the World Health Organization (WHO). Schistosomiasis also remains a public health issue with 207 million cases recorded globally and 280,000 deaths in the same year. Widespread emergence of parasite resistance to once-effective antimalarial options has rendered currently used drugs ineffective. Moreover, the current WHO-recommended first-line antimalarial drugs in clinical use, the artemisinin combination therapies (ACTs) are faced with the challenges of limited availability, unaffordable cost, and und
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21

Mayoka, Godfrey Wabwile. "Synthesis, pharmacological and physicochemical profiling of antimalarial and antischistosomal N-aryl 3-trifluoromethyl pyrido [1,2-α] benzimidazoles". Doctoral thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29825.

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Malaria and schistosomiasis represent the two most prevalent parasitic infections with grievous repercussions on the socio-economic development of affected countries, mainly in sub-Saharan Africa and South-East Asia. Despite their ravaging effects, the treatments of these two diseases have been committed to a limited arsenal of drugs that are threatened by resistance. This scenario, therefore, calls for decisive steps being taken towards the discovery and development of novel drugs with the ability to target multiple parasite stages and be efficacious against resistant parasite strains to achi
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22

Tran, Minh Quan. "Méthodologie de synthèse d'imidazoles et de benzimidazoles. Approche de synthèse de la benzosceptrine et évaluation biologique." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS068/document.

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Méthodologie d'addition-cyclisation de guanidines et amidines sur les quinones pour la synthèse de 2-aminobenzimidazole. Application de cette stratégie à la synthèse de benzo-bis-2-aminoimmidazole, un motif important de la benzosceptrine.Valorisation de produits synthétisés par évaluation biologique : l'inhibition de kinase, la cytotoxicité sur les lignées cellulaires cancéreuses du sang<br>Methodology of addition-cyclization of guanidines and amidines on quinones for the synthesis of 2-amino-benzimidazole. Applying this strategy to the synthesis of benzo-bis-2-aminoimmidazole, an analogue of
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23

Ndubi, Ferdinand Wafula. "Synthesis, pharmacological and solubility evaluation of antiplasmodial pyrido[1,2-a]benzimidazoles with cyclic and functionalized amine side chain substituents." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/22739.

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Malaria continues to cause significant morbidity and mortality globally, especially in sub-Saharan Africa where the disease is endemic. Widespread resistance by Plasmodium parasites to chloroquine and sulphadoxine-pyrimethamine, once mainstays of malaria treatment, has further set back control efforts. Recent reports of emerging resistance to ACTs, the current first-line antimalarial drugs, present an even grimmer picture in regard to future control and eradication of malaria. Moreover, antimalarial medications in current clinical use are fraught with challenges of high cost, low availability
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24

Li, Jihui. "Copper-Catalyzed Domino C-N Bond Formation for Synthesis of N-Containing Compounds (Benzimidazoles, Imidazoles, and Guanidines) - Approach toward Total Synthesis of Natural Product Raputindoles." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112130.

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Cette thèse est constituée de trois parties : 1) Le contexte bibliographique, 2) le développement de réactions domino cupro-catalysées et 3) une approche vers la synthèse totale des raputindoles.La première partie introduit d’abord le concept de réactions domino ainsi que leurs applications, puis les réactions catalysées par du cuivre permettant de former des liaisons C-N sont passées en revue en incluant les couplages de Ullmann, Goldberg et de Chan-Lam, les séquences d’activation oxydante de liaisons C-H/formation de liaison C-N, l’insertion de nitrènes et l’hydroamination de liaisons C-C mu
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25

Niemiec-Plebanek, Elzbieta. "Synthesis of small molecules targeting filovirus inhibition." Thesis, Orléans, 2014. http://www.theses.fr/2014ORLE2063.

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Les virus sont au centre de problème de santé publique. En raison de l'apparition de nouveaux virus et pour certains de leur résistance aux traitements existants il est toujours d’actualité de développement de nouveaux agents antiviraux. En général, la stratégie de lutte contre les infections virales est basée sur la vaccination ou sur l'activité des petites molécules, interférant avec un ou plusieurs processus biologiques participant au cycle de vie du virus. Dans ce contexte, nous avons conçu et synthétisé des petites bibliothèques de molécules visant des propriétés anti-filovirus. Dans ce p
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26

Ferger, Richard. "Synthesis, physicochemical and biological evaluation of N-dealkylated metabolites of antimalarial pyrido[1,2-a]benzimidazoles and related compounds containing a Mannich base side-chain." Master's thesis, Faculty of Science, 2020. http://hdl.handle.net/11427/32254.

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Malaria is one of the leading causes of deaths worldwide. Despite strategic implementations aimed at decreasing mortality and morbidity rates in recent decades, this plasmodial disease continues to impact public health and the economies of developing countries. Furthermore, the emergence of resistance toward current antimalarial treatments increases the necessity for the development of novel antimalarials. The benzimidazole scaffold is an extensively researched privileged scaffold in medicinal chemistry because of its capacity to interact with numerous biological systems in various diseases, i
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27

Karim, Rehana. "Development of radical synthetic methodology using solid-phase organic synthesis." Thesis, Loughborough University, 2003. https://dspace.lboro.ac.uk/2134/34406.

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The synthesis of heterocycles using radical intermediates has become an important area of research in recent years. The aim of our research was to develop radical methodologies to construct heterocycles on solid-support. Tri-cyclic benzimidazole derivatives are desirable synthetic targets with a range of biological activity and are part of certain anti-tumour agents. Solid-supported radical reactions with substituted benzimidazoles were performed under different experimental conditions, including different solvents, three different resins (Wang, Merrifield and Rink) and different radical reage
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28

Akpinar, Hava Zekiye. "Synthesis Of Benzimidazole Containing Donor Acceptor Electrochromic Polymers." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613006/index.pdf.

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ABSTRACT SYNTHESIS OF BENZIMIDAZOLE CONTAINING DONOR ACCEPTOR ELECTROCHROMIC POLYMERS Akpinar, Hava Zekiye M. Sc., Department of Chemistry Supervisor: Prof. Dr. Levent Toppare February 2011, 60 pages Donor-acceptor-donor (DAD) type benzimidazole (BIm) and 3,4-ethylenedioxythiophene (EDOT) bearing monomers (4-(2,3-Dihydrothieno[3,4-b][1,4]dioxin-5-yl)-7-(2,3 dihydrothieno[3,4b][1,4] dioxin-7-yl)-2-benzyl-1H-benzo[d]imidazole (M1), 2,4-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-7-(2,3-dihydrothieno[3,4-b][1,4]dioxin-7-yl)-1H-benzo[d]imidazole (M2) and 4-(2,3-dihydrothieno[3,4-b][1
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29

Howells, Ian Robert. "Synthetic studies on 1H-azepines benzimidazoles and quinoxalines." Thesis, University of Salford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308171.

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30

Ozelcaglayan, Ali Can. "Synthesis Of Electroactive Benzimidazole Derivatives And Their Electrochromic Properties." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12615196/index.pdf.

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In order to study their electrochemical and optical properties, two donor-acceptordonor (D-A-D) type monomers<br>4&#039<br>-(tert-butyl)-4,7-bis(4-hexylthiophen-2- yl)spiro[benzo[d]imidazole-2,1&#039<br>-cyclohexane] (BIHT) and 4&#039<br>-(tert-butyl)-4,7-bis(2,3- dihydrothieno[3,4-b][1,4]dioxin-5-yl)spiro[benzo[d]imidazole-2,1&#039<br>-cyclohexane] (BIED), were electrochemically polymerized. These properties were investigated by cyclic voltammetry and UV&ndash<br>Vis-NIR Spectroscopy techniques. Effects of different donor groups<br>3-hexylthiophene and 3, 4-ethylenedioxythiophene (EDOT), on n
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31

White, Wade M. "Synthesis and photoluminescent properties of linear and starburst compounds based on benzimidazole, 2-(2'-pyridyl)benzimidazole and 2,2'-dipyridylamine." Thesis, Kingston, Ont. : [s.n.], 2007. http://hdl.handle.net/1974/495.

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32

Carvalho, Luísa da Conceição Costa Rainho de. "Development of novel benzimidazole- based COX Inhibitors new synthetic strategies and screening of heterocyclic structures." Doctoral thesis, Faculdade de Ciencias e Tecnologia, 2014. http://hdl.handle.net/10362/13142.

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33

Namal, Imge. "Synthesis And Electrochemical Studies Of Fluorene And Benzimidazole Containing Conjugated Polymers." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615382/index.pdf.

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The synthesis and characterization of two donor acceptor type conjugated polymers were investigated. The electrochemical properties were examined using cyclic voltammetry, spectroelectrochemistry and kinetic studies. The increase in the alkyl chain length attached to the fluorene unit was investigated by the corresponding electrochemical characteristics. The synthesis was carried out via Stille coupling of 4,7- dibromo-4&#039<br>-(tert-butyl)spiro[benzo[d]imidazole-2,1&#039<br>cyclohexane] and 2,5- bis(tributylstannyl)thiophene with 9,9-dihexyl-9H fluorene and 9,9-didodecyl-9H fluorene respect
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34

Björk, Malin. "Synthesis of sulfur and seleniumn heterocycles, including derivatives of imidazopyridine and benzimidazole /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-597-6/.

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35

Downey, Aaron. "Synthesis and MAO activity of a series of benzimidazolyl and indazolyl prodrugs." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/35612.

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Parkinson's disease (PD) is a chronic, progressive disorder of the central nervous system that affects approximately 1.5 million Americans. One of the principal pathological features of PD is dopamine deficiency in the substantia nigra of the brain. A key enzyme that has been associated with the neurodegeneration seen in PD is monoamine oxidase-B (MAO-B). Several inhibitors of this enzyme have resulted in neuroprotection in the mouse model of PD. One such compound is 7-nitroindazole (1). This thesis describes the synthesis and MAO activity of several indazolyl and benzimidazolyl prodrugs tha
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36

L'abbate, Fabrizio P. "Synthesis and investigation of benzimidazole and carbazole ß-haematin inhibiting scaffolds with antimalarial activity." Thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/28432.

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Chloroquine was one of the main malarial treatments until the late 1960s when resistance began to emerge. This antimalarial targets haemozoin formation which causes a cytotoxic accumulation of free haem in the malaria parasite leading to parasite death. This is still one of the most promising pathways for treatment of the most prevalent species of malaria parasite, Plasmodium falciparum to date but, owing to growing resistance to chloroquine and other current antimalarial drugs, there is a dire need for new drugs. One strategy is to investigate non-chloroquine haemozoin inhibitors. High-throug
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Chang, Ying-Ching, and 張孆璟. "Synthesis of Anticacer Bis (benzimidazoles) Library and Benzimidazolyl benzoxazole Related to UK-1." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/8s3bfm.

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38

Gao, Jing-Yan, and 高敬彥. "Synthesis of benzimidazoles as antiangiogenesis agents." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/99ecmt.

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Su, Yuh-Sheng, and 蘇裕勝. "Liquid-Phase Combinatorial Synthesis of Benzimidazoles." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/45051713465869007110.

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40

Chang, Ling-Ju, and 張菱洳. "Liquid-Phase Combinatorial Synthesis of Benzimidazoles Derivative." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/36944687688481446566.

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41

ZENG, Cian-Jhe, and 曾乾哲. "Copper-Catalyzed Synthesis of Guanidines and Benzimidazoles." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/94790879466750254152.

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碩士<br>國立臺灣師範大學<br>化學系<br>102<br>This thesis contains three parts: In the first and second parts of the thesis , we investigated the utilitzation of copper(I) iodide-catalyzed reaction of N-substituted cyanamides to systhsize a wide variety of N,N’-disubstituted guanidine and 2-aminobenzimidazole derivatives. At the same time, In the third part, the synthetic approach of an epigenetic DNA base 5-hydroxymethyl-2’-deoxycytidine (5-hmdC), was studied. In the first part, N-alkyl-N’-arylguanidines could be effectively synthesized through the reaction of N-arylcyanamides with various primary and seco
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42

Yeh, Chih-Ming, and 葉智銘. "Liquid-Phase Combinatorial Synthesis of 2-alkylthio benzimidazoles." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/31942272070127262117.

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碩士<br>國立東華大學<br>化學研究所<br>87<br>Abstract The use of combinatorial chemistry techniques to rapidly generate large numbers of diverse small-molecule combinatorial libraries has become an accepted tool in the quest for new pharmaceutically active compounds, it has been an important tool for the synthesis of a large number of pharmaceutically interesting compounds, In couples with high capacity screening system, provide a very important strategy for generation drug leads as well as for optimizing leas compounds, this technology may revolutionize the drug discovery process.
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Chen, Yen-Ju, and 陳彥儒. "Conjugation of Benzimidazoles with Coumarins: Their Synthesis and Conformation." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/17988990404710744571.

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碩士<br>國立中央大學<br>化學研究所<br>98<br>We successfully obtained thirteen hinged benzimidazole–coumarin hybrids; these compounds were obtained by simple chemical synthesis. By studies of the spectra of nuclear magnetic resonance and infrared spectroscopy as well as the outcomes of molecular modeling, we conclude that the conformation with the thermodynamically most stable form did not contain intramolecular hydrogen bondings between the NH proton in benzimidazole and the carbonyl group in coumarin. The angle between benzimidazole and coumarin planes were 63.967°–85.705°. In the future, we will discu
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廖本原. "(1) Synthetic Studies of Benzimidazoles from Amidoximes (2) Copper-Catalyzed Synthesis of Indoles." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/04716447104067185921.

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碩士<br>國立臺灣師範大學<br>化學系<br>102<br>This thesis covers two separated topics. The first part is the synthesis of N-phenyl hetero-aryl carboxamidoximes with different substituents on the bezene ring. The reaction of the N-phenyl hetero-aryl carboxamidoximes with p-toluenesulfonic anhydride undergoes a direct intramolecular electrophilic aromatic substitution at low temperature, to afford 2-hetero-arylbenzimidazole derivatives. Moreover, we also found that the reaction of arylcarboxamidoximes with different sulfonyl reagents undergo Tiemann rearrangement reaction to afford corresponding of N,N’-disub
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Wu, Wen-Chun, and 吳玟君. "Design and Synthesis of Diverse Pyrimidopyrroloquinoxalinediones,Metal-Assisted Synthesis of Benzimidazoles Molecular Library." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/keej4j.

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Alamgir, Mahiuddin Chemistry Faculty of Science UNSW. "Synthesis and reactivity of some activated heterocyclic compounds." 2007. http://handle.unsw.edu.au/1959.4/40831.

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An alternate approach to the synthesis of calix[3]indoles has been demonstrated, but further attempted synthetic approaches to calixindoles using new leaving groups led to uncharacterized polymeric products. The synthesis of new 7,7'-diindolylmethane- 2,2'-dicarbaldehydes gives potential for further ligand design and metal complex formation. In addition, 4,6-dimethoxyindole-7- carbaldehydes have been effectively converted to a range of 6-methoxyindole-4,7-diones by Dakin oxidation. Various electrophilic substitution reactions have been performed on the 4,6-dimethoxybenzimidazoles. Formylation
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Garner, Matthew L. "Design, Synthesis and Study of DNA-Targeted Benzimidazole-Amino Acid Conjugates." 2013. http://hdl.handle.net/1805/3360.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The DNA minor groove continues to be an important biological target in the development of anticancer, antiviral, and antimicrobial compounds. Among agents that target the minor groove, studies of well-established benzimidazole-based DNA binders such as Hoechst 33258 have made it clear that the benzimidazole-amidine portion of these molecules promotes an efficient, site-selective DNA association. Building on the beneficial attributes of existing benzimidazole-based DNA binding agents, a series of benzimidazole-amino acid conjugates
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CHEN, HAN-LONG, and 陳漢隆. "Studies on the synthesis and properties of lyotropic liquid crystalline polyamido-benzimidazoles." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/10494003974699778058.

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碩士<br>中原大學<br>化學工程研究所<br>78<br>Benzimidazoles聚合物的合成，始於1950年，K.C.Brinker I.M.Robinson和bi-odia- mine和脂肪族二酸(asiphatie dicarboxy acid)，首先合成了polybenaimidazoles(- PBI), 1961年，H.Vogel 和C.S.Marvel，合成了全芳香性的PBI ，由於PBI 具有良好 的耐熱性和機械強度，使得PBI 受到眾多的矚目，目前美國太空總署(NASA)和空軍材 料室(AFML)將PBI 運用於航太工業和防御材料上，例如：複合材料，耐高溫接著劑， 防護外套等。 本研究是合成6-amino-2-(p-aminophenyl)-benzimidazole 二胺單體，和對羧酸基肉 桂酸(p-carboxylic cinnamic acid)對苯二丙烯酸(p-phenylenebisacrylic acid), N-(p-carboxyphenyl)trimellitimide 等二酸單體，採用直接縮合法(Di
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HSIAO, CHIEN-CHUNG, and 蕭建中. "Synthesis and Characterization of Polyimides Containing Benzimidazoles Groups for Proton Exchange Membrane." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/u865vx.

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碩士<br>國立臺灣科技大學<br>化學工程系<br>107<br>A Novel diamine 3-(2-(5-aminobenzimidazolyl))aniline(m/IM/NH2), containing benzimidazole backbone was synthesized. The polyimides (PIs) were prepared by polycondensation of the diamines and Naphtha-lenetetracarboxylic dianhydride(NTDA). They had inherent viscosities in the range of 1.01~1.59 dL/g, and they could form tough and flexible films. The PIs exhibited high thermal stability with 10% decomposition temper-ature more than 530℃ in nitrogen, and their onset temperature was more than 500℃ in nitrogen. These films exhibited good mechanical properties with te
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Yi, Shuyan. "Design and synthesis of benzimidazoles as CDK5 inhibitors and progress toward the total synthesis of tubulysin D." 2009. http://digital.library.duq.edu/u?/etd,101009.

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