Relevant bibliographies by topics / Benzodiazepines – Metabolism

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters

Academic literature on the topic 'Benzodiazepines – Metabolism'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Benzodiazepines – Metabolism.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Benzodiazepines – Metabolism"

1

Prommer, Eric. "Midazolam: an essential palliative care drug." Palliative Care and Social Practice 14 (January 2020): 263235241989552. http://dx.doi.org/10.1177/2632352419895527.

Full text
Abstract:
Midazolam is a commonly used benzodiazepine in palliative care and is considered one of the four essential drugs needed for the promotion of quality care in dying patients. Acting on the benzodiazepine receptor, it promotes the action of gamma-aminobutyric acid. Gamma-aminobutyric acid action promotes sedative, anxiolytic, and anticonvulsant properties. Midazolam has a faster onset and shorter duration of action than other benzodiazepines such as diazepam and lorazepam lending itself to greater flexibility in dosing than other benzodiazepines. The kidneys excrete midazolam and its active metab
APA, Harvard, Vancouver, ISO, and other styles
2

Perkovic-Vukcevic, Natasa, Gordana Vukovic-Ercegovic, Zoran Segrt, Snezana Djordjevic, and Jasmina Jovic-Stosic. "Benzodiazepine poisoning in elderly." Vojnosanitetski pregled 73, no. 3 (2016): 234–38. http://dx.doi.org/10.2298/vsp141208025p.

Full text
Abstract:
Background/Aim. Benzodiazepines are among the most frequently ingested drugs in self-poisonings. Elderly may be at greater risk compared with younger individuals due to impaired metabolism and increased sensitivity to benzodiazepines. The aim of this study was to assess toxicity of benzodiazepines in elderly attempted suicide. Methods. A retrospective study of consecutive presentations to hospital after self-poisoning with benzodiazepines was done. Collected data consisted of patient's characteristics (age, gender), benzodiazepine ingested with its blood concentrations at admission, clinical f
APA, Harvard, Vancouver, ISO, and other styles
3

Seubert, Christoph N., Timothy E. Morey, Anatoly E. Martynyuk, Roy F. Cucchiara, and Donn M. Dennis. "Midazolam Selectively Potentiates the A2A- but not A1-receptor– mediated Effects of Adenosine." Anesthesiology 92, no. 2 (2000): 567. http://dx.doi.org/10.1097/00000542-200002000-00041.

Full text
Abstract:
Background Inhibition of adenosine metabolism offers a unique approach to harness the cardioprotective properties of adenosine in a site- and event-specific manner. Benzodiazepines inhibit adenosine metabolism by blocking nucleoside transporter. Therefore, the authors studied the binding affinities of structurally different benzodiazepines to nucleoside transporter and benzodiazepine-induced potentiation of A1-adenosine (negative dromotropy) and A2A-adenosine (coronary vasodilation) receptor-mediated effects. Methods In membranes from porcine striatum and guinea pig ventricle, competition bind
APA, Harvard, Vancouver, ISO, and other styles
4

Gool, Dominique Van. "Different modes of action of alprazolam in the treatment of panic attacks." Acta Neuropsychiatrica 12, no. 2 (2000): 41–45. http://dx.doi.org/10.1017/s0924270800035687.

Full text
Abstract:
SUMMARYAlprazolam (a benzodiazepine in the group of the triazolo-benzodiazepines) is a potent drug for the treatment of panic disorder. This is possible due to four different interactions with neurotransmitter systems. First, it facilitates, as all diazepines, the inhibitory acitivity of gamma-amino-butyricacid (GABA). The chemical structure differs from the benzodiazepines by incorporation of the triazoloring. Due to this triazoloring, the drug has three additional modes of action. These modes of action inhibit the locus coeruleus which plays a role in the origin of panic disorder. A first sp
APA, Harvard, Vancouver, ISO, and other styles
5

Wallace, IR, EC Campbell, and Micheal Trimble. "Use of a flumazenil infusion to treat chlordiazepoxide toxicity." Acute Medicine Journal 16, no. 1 (2017): 30–34. http://dx.doi.org/10.52964/amja.0649.

Full text
Abstract:
“Alcohol detox” is a common presentation to acute medical services and is usually managed via standardised guidelines and protocols. We present a case of chlordiazepoxide toxicity, requiring repeated bolus doses and subsequently 24 hours of an intravenous infusion of flumazenil in response to guideline directed management of an alcohol withdrawal state. The use of prolonged flumazenil infusions to treat benzodiazepine toxicity is infrequently described. Chlordiazepoxide is metabolised in the hepatic microsomal pathway and hepatic impairment can lead to accumulation of toxic metabolites, which
APA, Harvard, Vancouver, ISO, and other styles
6

Carter, Laura J., Mike Williams, Sheridan Martin, Sara P. B. Kamaludeen, and Rai S. Kookana. "Sorption, plant uptake and metabolism of benzodiazepines." Science of The Total Environment 628-629 (July 2018): 18–25. http://dx.doi.org/10.1016/j.scitotenv.2018.01.337.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Whitehouse, B. J. "Benzodiazepines and steroidogenesis." Journal of Endocrinology 134, no. 1 (1992): 1–3. http://dx.doi.org/10.1677/joe.0.1340001.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Santosh, SR, S. Sampath, and A. Gupta. "Simultaneous analysis of eight benzodiazepines in blood and urine matrix by gas chromatography–mass spectrometry: Implications for air crash investigation." Indian Journal of Aerospace Medicine 63 (November 7, 2019): 2–7. http://dx.doi.org/10.25259/ijasm_2019_2.

Full text
Abstract:
Introduction: Benzodiazepines are the most commonly prescribed class of drugs in India and are capable of impairing the performance of an aviator in therapeutic to subtherapeutic levels. Detection of benzodiazepines, particularly in blood, is not easy, since the concentrations present, especially following prescribed medical use, can be very low. Several publications have addressed estimation of benzodiazepines in plasma or serum; however, few have attempted their detection in whole blood. Urine, although a better specimen, benzodiazepines due to their extensive metabolism, its metabolites are
APA, Harvard, Vancouver, ISO, and other styles
9

Hooper, W. D., J. A. Watt, G. E. Mckinnon, and P. E. B. Reelly. "Metabolism of diazepam and related benzodiazepines by human liver microsomes." European Journal of Drug Metabolism and Pharmacokinetics 17, no. 1 (1992): 51–59. http://dx.doi.org/10.1007/bf03189988.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Harvey, S. "Benzodiazepine antagonism of thyrotrophin-releasing hormone receptors: biphasic actions on growth hormone secretion in domestic fowl." Journal of Endocrinology 137, no. 1 (1993): 35–42. http://dx.doi.org/10.1677/joe.0.1370035.

Full text
Abstract:
ABSTRACT Benzodiazepines are pharmacological agents widely used for their anxiolytic and anticonvulsant properties. However, as these drugs are known to antagonize the binding and action of thyrotrophin-releasing hormone (TRH) in pituitary tissue, the possibility that they may modulate GH secretion was investigated in domestic fowl, in which TRH is a GH-releasing factor. Chlordiazepoxide (an antagonist of central-type benzodiazepine receptors) had no significant effect on the basal release of GH from incubated chicken pituitary glands, but at concentrations > 10 μmol/l chlordiazepoxide supp
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Benzodiazepines – Metabolism"

1

Borel, Anthony Gerard Francis. "The metabolic profiling of clobazam in rats." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28921.

Full text
Abstract:
Clobazam (CLBZ) is a 1,5-benzodiazepine with potent anticonvulsant activity. The metabolism of this drug was investigated in the rat and in vitro with the aid of stable isotope-labelled analogues and gas chromatography-mass spectroscopy (GCMS). Pentadeuteriophenyl CLBZ [²H₅]CLBZ was synthesized in essentially quantitative isotopic purity, and characterized by ¹H-NMR and GCMS. Of the five steps involved in the synthesis of [²H₅]CLBZ, the most susceptible to deuterium exchange was the nucleophilic substitution of 2,4-dichloronitrobenzene by aniline-d₇ to form N-(5-chloro-2-nitrophenyl)pentadeut
APA, Harvard, Vancouver, ISO, and other styles
2

Overturf, Carmen L. "Investigation of the Pharmacokinetics of Diazepam in Juvenile Channel Catfish (Ictalurus Punctatus)." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc407799/.

Full text
Abstract:
The presence of pharmaceuticals in the environment is becoming an increasing regulatory and scientific concern. Thus, the metabolic profile and bioconcentration potential of diazepam, a model benzodiazepine, were examined, as well as effects on the endocrine system in channel catfish. Through the use of specific and non-specific cytochrome P450 (CYP450) inhibitors, it was determined that CYP3A-like enzymes may play a role in the biotransformation of diazepam into temazepam; however, the isoform(s) required for the formation of other metabolites is still unknown. Overall, only around 7-8% of di
APA, Harvard, Vancouver, ISO, and other styles
3

ANTONI, MICHEL. "Metabolisme hepatique des medicaments : principes generaux ; analyse au cours des hepatopathies appliquees aux benzodiazepines et a l'etude pharmacocinetique du clobazam et du flunitrazepam." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20053.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Chytil, Lukáš. "Chirální a achirální chromatografie ve farmakologii a toxikologii." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-296132.

Full text
Abstract:
Development and validation of methods for analysis of several drugs or their metabolites are decribed in this thesis. The document is presented as a commentary to the original papers, which were published in peer reviewed journals. Discussion on the optimization of each method is presented and covers also method development and influence of preanalytical aspects. Additionally, examples of the application of the developed methods in clinical pharmacology and toxicology are shown. This dissertation consists of three parts: enantiomeric determination of tramadol and its metabolite, determination
APA, Harvard, Vancouver, ISO, and other styles
5

Pallmann, Tanja [Verfasser]. "Darstellung verschiedener Benzodiazepin-Glucuronide sowie die Testung der Benzodiazepine hinsichtlich ihres Interaktionspotentials im Phase-II-Metabolismus mit Opiaten / vorgelegt von Tanja Pallmann." 2007. http://d-nb.info/98724096X/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Hochhauser, D., T. Meyer, V. J. Spanswick, et al. "Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors." 2009. http://hdl.handle.net/10454/6020.

Full text
Abstract:
PURPOSE: This phase I dose-escalation study was undertaken to establish the maximum tolerated dose of the sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors. The study also investigated antitumor activity and provided pharmacokinetic and pharmacodynamic data. EXPERIMENTAL DESIGN: Sixteen patients were assigned sequentially to escalating doses of SJG-136 (15-240 microg/m(2)) given as a 10-minute i.v. infusion every 21 days. The dose was subsequently reduced in incremental steps to 45 microg/m(2) due to unexpected toxicity. RESULTS: The maximum toler
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Benzodiazepines – Metabolism"

1

The benzodiazepine receptor: Drug acceptor only or a physiologically relevant part of our central nervous system? Cambridge University Press, 1987.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

NATO Advanced Research Workshop on Molecular Biology of Neuroreceptors and Ion Channels (1988 Thera Island, Greece). Molecular biology of neuroreceptors and ion channels. Springer-Verlag, 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Peppin, John, Joseph V. Pergolizzi, Robert B. Raffa, and Steven L. Wright, eds. The Benzodiazepines Crisis. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780197517277.001.0001.

Full text
Abstract:
When properly prescribed, benzodiazepines and related “Z” drugs, are usually safe and effective. However, some patients experience lack of efficacy, severe adverse effects, and/or protracted withdrawal symptoms. Unfortunately, there is no reliable way to predict outcome prior to treatment. Use has dramatically expanded, to the point where some experts suggest a disconnect with actual medical need. With increased and longer prescribing there has been a corresponding increase in the “down-side” of these drugs. Benzodiazepines, as all drugs, produce some degree of normal physiologic tolerance and
APA, Harvard, Vancouver, ISO, and other styles
4

J, Salamone Salvatore, ed. Benzodiazepines and GHB: Detection and pharmacology. Humana Press, 2001.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Salamone, Salvatore J. Benzodiazepines and GHB: Detection and Pharmacology. Humana Press, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Giovanni, Biggio, Costa Erminio, and Capo Boi Conference on Neuroscience (5th : 1987 : Villasimius, Italy), eds. Chloride channels and their modulation by neurotransmitters and drugs. Raven Press, 1988.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

E, Giesen-Crouse, ed. Peripheral benzodiazepine receptors. Academic Press, 1993.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Martin, Sarter, Nutt David J. 1951-, and Lister Richard G, eds. Benzodiazepine receptor inverse agonists. Wiley-Liss, 1995.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

1944-, Hindmarch I., Ott H, and Collegium Internationale Neuro-psychopharmacologicum Congress, eds. Benzodiazepine receptor ligands, memory, and information processing: Psychometric, psychopharmacological, and clinical issues. Springer-Verlag, 1988.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Pierre, Marie Vivien St. Sequential metabolic processing in the liver: a study of benzodiazepines in the perfused mouse liver. 1991.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Benzodiazepines – Metabolism"

1

Pauli, S., H. Hall, C. Halldin, and G. Sedvall. "Spatial Benzodiazepine Receptor Imaging in the Human Brain." In GABA: Receptors, Transporters and Metabolism. Birkhäuser Basel, 1996. http://dx.doi.org/10.1007/978-3-0348-8990-2_29.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Kawasaki, Kazuo, Tsuyoshi Kihara, Shunji Murata, et al. "A Novel Benzodiazepine Partial Inverse Agonist, S-8510, as a Cognitive Enhancer." In GABA: Receptors, Transporters and Metabolism. Birkhäuser Basel, 1996. http://dx.doi.org/10.1007/978-3-0348-8990-2_28.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Heinemeyer, G., and J. Link. "Bedeutung des Metabolismus für die Anwendung von Benzodiazepinen auf Intensivstationen." In Analgesie und Sedierung in der Intensivmedizin. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75081-6_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Raffa, Robert B. "Benzodiazepine Receptors in the Periphery." In The Benzodiazepines Crisis. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780197517277.003.0006.

Full text
Abstract:
The benzodiazepines are almost universally thought to produce one and only one pharmacologic effect: positive allosteric modulation of GABA<sub>A</sub> receptors located in the brain. This results in an increased Cl−ion influx, greater negative transmembrane potential difference, and neurons that are less likely to fire in response to anxiety-producing stimulation. Unfortunately, the simplicity and success of this mono-target belief has distracted researchers and clinicians from studying and appreciating their other pharmacology. A glaring example is the general lack of awareness of the peripheral benzodiazepine receptor. The peripheral benzodiazepine receptor alters mitochondrial function (energy supply), cholesterol transport, and immune function. A patient who is on long-term benzodiazepine therapy (or withdrawing from them) will have these sites affected, just as are the sites located in the brain. One can easily imagine that the adverse effects associated with the peripheral sites would be fundamental, varied, and potentially profound—involving lack of energy, altered cholesterol metabolism, and aberrant immune function.
APA, Harvard, Vancouver, ISO, and other styles
5

Hansen, Jamie L., and Timothy J. Atkinson. "The Evolution of Benzodiazepine Receptor Agonists." In The Benzodiazepines Crisis. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780197517277.003.0002.

Full text
Abstract:
Benzodiazepines have been touted as safer alternatives to their barbiturate predecessor since their arrival on the market in 1960. Their proposed improved safety is based on their reported reduced drug interactions, lower abuse potential, and decreased respiratory depression. Benzodiazepines bind to the GABA<sub>A</sub> receptor and positively modulate GABAergic transmission and hyperpolarization of neuronal membranes. Individual agents are utilized differently depending on their varying degrees of hypnotic, anxiolytic, antiepileptic, muscle relaxant, and amnestic properties. Benzodiazepines are frequently classified by their half-life (t<sub>½</sub>), a key pharmacokinetic parameter that dictates the agents’ ability to precipitate dangerous withdrawals. The majority of benzodiazepines undergo phase I hepatic metabolism via cytochrome p450 that introduce the potential for drug interactions. Following hepatic metabolism, almost all agents within this drug class have active metabolites that have extended half-lives beyond that of the parent drug that prolong the duration of activity. Urine drug screens are an essential component of medication monitoring and require a foundational understanding of the parent drug, its metabolites, and what the available immunoassay is designed to detect. A similar drug class that is frequently grouped with benzodiazepines are Z-drugs. These agents were developed in attempt to create a sleep aid that lacked the undesirable qualities of benzos with an improved safety profile. Z-drugs share the common characteristic of being short-acting in nature and are proposed to cause less disruption in the normal sleep cycle than benzodiazepines.
APA, Harvard, Vancouver, ISO, and other styles
6

LÁNG, T., J. KORÖSI, G. ZÓLYOMI, T. HÁMORI, and P. BOTKA. "DESIGN AND SYNTHESIS OF 5H-2,3-BENZODIAZEPINES." In Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism. Elsevier, 1986. http://dx.doi.org/10.1016/b978-0-08-034191-0.50017-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

KENESSEY, A., P. PÁLDI-HARIS, L. GRÁF, T. LÁNG, and J. KORÖSI. "THE EFFECT OF 2,3-BENZODIAZEPINES ON THE BENZODIAZEPINE-GABA-PICROTOXIN/BARBITURATE-CI-ION CHANNEL COMPLEX." In Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism. Elsevier, 1986. http://dx.doi.org/10.1016/b978-0-08-034191-0.50027-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Metz, John T., Harriet de Wit, Malcolm Cooper, and John Metz. "Effects of Benzodiazepines on Behavior, Mood, and Regional Cerebral Metabolism." In SITES of DRUG ACTION in the HUMAN BRAIN. CRC Press, 2020. http://dx.doi.org/10.1201/9780367811419-4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Mendoza, Kelly, Jessica Geiger-Hayes, and Mary Lynn McPherson. "Frequent Pharmacological Interactions in Palliative Care." In Hospice and Palliative Medicine and Supportive Care Flashcards. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190633066.003.0016.

Full text
Abstract:
Pharmacodynamic (increasing or decreasing the effect of a medication on the body) and pharmacokinetic (altering the absorption, distribution, metabolism, and/or excretion of a medication) interactions are important in palliative care. These interactions are similar to those seen in other areas of medical care, but they have significant consequences in pain and symptom management. Failure to recognize these interactions can lead to overdosing, undertreatment, or increased side effect burden. This chapter highlights the key topics regarding pharmacodynamic and pharmacokinetic interactions and provides examples that include the commonly used opioids such as codeine and methadone, as well as benzodiazepines and other symptom management medications.
APA, Harvard, Vancouver, ISO, and other styles
10

VALDMAN, A. V., V. V. ROSHANETS, N. D. DANTCHEV, K. M. MALIN, K. K. CHABRA, and R. A. ACKHUNDOV. "INTERACTION OF DIFFERENT COMPOUNDS, HAVING ATYPICAL ANXIOLYTIC PROPERTIES WITH GABA-BENZODIAZEPINE RECEPTOR COMPLEX." In Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism. Elsevier, 1986. http://dx.doi.org/10.1016/b978-0-08-034191-0.50024-6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Benzodiazepines – Metabolism' for particular source types:
Journal articles Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography