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Books on the topic 'Benzodiazepines – Metabolism'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

The benzodiazepine receptor: Drug acceptor only or a physiologically relevant part of our central nervous system? Cambridge University Press, 1987.

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2

NATO Advanced Research Workshop on Molecular Biology of Neuroreceptors and Ion Channels (1988 Thera Island, Greece). Molecular biology of neuroreceptors and ion channels. Springer-Verlag, 1989.

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3

Peppin, John, Joseph V. Pergolizzi, Robert B. Raffa, and Steven L. Wright, eds. The Benzodiazepines Crisis. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780197517277.001.0001.

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When properly prescribed, benzodiazepines and related “Z” drugs, are usually safe and effective. However, some patients experience lack of efficacy, severe adverse effects, and/or protracted withdrawal symptoms. Unfortunately, there is no reliable way to predict outcome prior to treatment. Use has dramatically expanded, to the point where some experts suggest a disconnect with actual medical need. With increased and longer prescribing there has been a corresponding increase in the “down-side” of these drugs. Benzodiazepines, as all drugs, produce some degree of normal physiologic tolerance and

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4

J, Salamone Salvatore, ed. Benzodiazepines and GHB: Detection and pharmacology. Humana Press, 2001.

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5

Salamone, Salvatore J. Benzodiazepines and GHB: Detection and Pharmacology. Humana Press, 2010.

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6

Giovanni, Biggio, Costa Erminio, and Capo Boi Conference on Neuroscience (5th : 1987 : Villasimius, Italy), eds. Chloride channels and their modulation by neurotransmitters and drugs. Raven Press, 1988.

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7

E, Giesen-Crouse, ed. Peripheral benzodiazepine receptors. Academic Press, 1993.

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8

Martin, Sarter, Nutt David J. 1951-, and Lister Richard G, eds. Benzodiazepine receptor inverse agonists. Wiley-Liss, 1995.

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9

1944-, Hindmarch I., Ott H, and Collegium Internationale Neuro-psychopharmacologicum Congress, eds. Benzodiazepine receptor ligands, memory, and information processing: Psychometric, psychopharmacological, and clinical issues. Springer-Verlag, 1988.

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10

Pierre, Marie Vivien St. Sequential metabolic processing in the liver: a study of benzodiazepines in the perfused mouse liver. 1991.

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11

1951-, Marescaux C., Vergnes M. 1935-, and Bernasconi R. 1929-, eds. Generalized non convulsive epilepsy: Focus on GABA-B receptors. Springer-Verlag, 1992.

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12

Marescaux, C., M. Vergnes, and R. Bernasconi. Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors. Springer, 2012.

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13

(Editor), C. Marescaux, M. Vergnes (Editor), and R. Bernasconi (Editor), eds. Generalized Non Convulsive Epilepsy: Focus on Gaba-B Receptors ("Journal of Neural Transmission"). Springer-Verlag, Austria, 1992.

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14

Marescaux, C., and M. Vergnes. Generalized Non Convulsive Epilepsy: Focus on Gaba-B Receptors (Journal of Neural Transmission Supplementum). Springer, 1992.

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15

Ellison, Justin C., Jason B. Rosenstock, and Michael J. Marcsisin. Somatic Treatments for Psychotic Disorders. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199331505.003.0006.

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A variety of somatic therapies can be used to treat individuals suffering from psychosis. Most commonly, providers will prescribe antipsychotics, which generally block dopamine receptors and are particularly useful at reducing positive symptoms. Second-generation antipsychotics have fewer movement side effects than older agents do, but they are more expensive and have more metabolic side effects. Long-acting injectable (LAI) antipsychotics can be useful for improving outcomes, especially in non-adherent patients, and clozapine is the gold standard for treatment-refractory psychosis. Other agen

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16

Sullivan, Maria A. Conclusion. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199392063.003.0012.

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Addiction in older adults very often goes unrecognized, for several reasons: social biases about the elderly, age-related metabolic changes, and the inappropriate use of prescription benzodiazepines and opioids to address untreated anxiety and mood conditions. Alcohol or substance-use disorders (SUDs) in older individuals may present in subtle and atypical ways. Strategies to overcome such difficulties include systematic screening using validated instruments, patient education regarding the impact of psychoactive substances on health, and cautious prescribing practices. Relying on standard DSM

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17

Sullivan, Maria, and Frances Levin, eds. Addiction in the Older Patient. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199392063.001.0001.

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Addictive disorders in older adults are underdiagnosed and undertreated. An important reason for this lack of recognition of a serious health problem is a paucity of clinical knowledge about how such disorders present in this population. The presentation for alcohol and substance use disorders in the elderly can be confusing, given the metabolic changes and concurrent conditions associated with aging, together with interactions between alcohol and prescribed psychoactive drugs. Further, screening instruments have not been validated for this population. Brief interventions may be effective but

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18

(Editor), T. Kumazawa, L. Kruger (Editor), and K. Mizumura (Editor), eds. The Polymodal Receptor - A Gateway to Pathological Pain (Progress in Brain Research). Elsevier Science, 1996.

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19

Takao, Kumazawa, Kruger Lawrence, and Mizumura Kazue, eds. The polymodal receptor: A gateway to pathological pain. Elsevier, 1996.

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