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Dissertations / Theses on the topic 'Benzothiazine'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Miranda, Guarda Vera Lucia de. "1,4-benzothiazinones et thiazolidinones substituées : synthèse, étude stucturale et activité antibactérienne." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE18004.

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2

Spitz, Cédric. "Synthèse et réactivité de sulfénamides cycliques énantiopurs : Accès facile à des 1,4-benzothiazépines et à des1,3-benzothiazines." Caen, 2009. http://www.theses.fr/2009CAEN2046.

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Cette thèse traite de la synthèse et de la réactivité de benzisothiazolines, des sulfénamides cycliques énantiopurs. Ces composés ont été facilement préparés à partir de sulfoxydes énantiopurs en deux étapes avec de bons rendements globaux (de 36 à 62%). Toutefois, le potentiel synthétique de ces derniers n’a jamais été exploité. Dans ce contexte, nous avons donc décidé d’étudier leur réactivité vis-à-vis d’alcynes afin de synthétiser des 1,4-benzothiazépines. Nous avons ainsi développé une méthode originale utilisant l’ion fluorure en tant que catalyseur nucléophile. Cela a permis la synthèse
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3

Al-Nawar, Karim François. "Synthesis of novel benzothiazine and benzodiazepine-1,1-dioxide derivatives." Thesis, University of Hertfordshire, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431933.

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4

Huang, Chaofeng Harmata Michael. "Studies of 2,1-benzothiazine, silver-catalyzed rearrangement and 1,5-hydride shift." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/6971.

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Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 26, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Thesis advisor: Dr. Michael Harmata. Vita. Includes bibliographical references.
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5

Rayanil, Kanok-on. "Studies of the chemistry of Tröger's base, cyclopentadienones, and 2,1-benzothiazines." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/5861.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed Aug. 10, 2007). Vita. Includes bibliographical references.
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6

Ying, Weijiang Harmata Michael. "Study of the chemistry of 2,1-benzothiazines and toward the total synthesis of elisapterosin B." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/6968.

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Title from PDF of title page (University of Missouri--Columbia, viewed on March 1, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dissertation advisor: Dr. Michael Harmata. Vita. Includes bibliographical references.
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7

Schulz, Knut. "Beitrag zur Synthese und Chemie von 2H-Benzo(1,4)chalkogenazinen Darstellung neuer Lactamstrukturen, Tetrazole und Aminoketone." Berlin mbv, 2008. http://d-nb.info/992998670/04.

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8

Billon, Florence. "Synthèse de dérivés originaux inhibiteurs de l'aldose réductase." Paris 5, 1989. http://www.theses.fr/1989PA05P624.

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9

MOUATS, CHABANE. "Electrosynthese de derives de la quinoleine, de la 2h-1,4-benzoxazine et de la 2h-1,4-benzothiazine par electroreduction d'o-nitrobenzenes substitues." Rennes 1, 1993. http://www.theses.fr/1993REN10079.

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La reduction electrochimique a potentiel controle de nitrobenzenes ortho-substitues a ete utilisee pour la preparation d'heterocycles azotes. La premiere partie de ce travail est consacree a l'obtention de n-oxy et n-hydroxyquinoleines a partir de derives o-nitrobenzoyles. L'etude des derives monofonctionnalises permet de montrer que la reactivite des substituants envisages, vis-a-vis de la fonction hydroxylamine, decroit dans l'ordre coch#3>coc#6h#5>co#2r>cn. Ce classement a pu etre verifie a partir de derives difonctionnalises: la cyclisation est chimioselective lorsque les affinites des deu
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10

Fowler, Anne Michelle. "Metabolism of benzothiazole." Thesis, University of Hertfordshire, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314573.

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11

Foster, Robert. "Cyclic sulphonium ylides derived from 1,4-benzothiazines and 1,4-thiazines." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303666.

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12

Blunt, Christoper Edward. "The synthesis of benzisothiazole and benzothiazole natural products." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49541/.

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Chapter 1 gives an introduction to benzisothiazole and benzothiazole natural products. It explores the scope of natural products that are known within these families and discusses what they are used for, how they have been made and how they may have been biosynthesised. Chapter 1 provides a review of each family of natural products in turn. Chapter 2 describes the total synthesis of the benzisothiazole natural products aulosirazole and pronqodine A, and a series of unnatural analogues. The Chapter begins with a short discussion on the use of the Diels-Alder reaction for the formation of naphth
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13

Billeau, Sébastien. "Synthèse de molécules dérivées du benzothiazole et de la tétrahydroacridine." Aix-Marseille 3, 2004. http://www.theses.fr/2004AIX30033.

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Au cours de ce travail, nous avons développé la synthèse d’une nouvelle famille de composés : les thiazolo-tétrahydroacridines. Une stratégie de synthèse a été élaborée puis optimisée et nous avons ainsi obtenu huit molécules originales. De nombreux composés benzothiazoliques préparés au cours de ce travail en tant qu’intermédiaires de synthèse, présentent, eux aussi, un intérêt certain. Ceci nous a permis de valoriser ces produits. Tous les composés synthétisés sont en cours d’évaluation dans différents domaines d’activité et notamment dans le domaine thérapeutique. Certains résultats au nive
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14

Bunescu, Andrei. "Photo-et biodégradation de dérivés du benzothiazole : étude en système combiné." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2006. http://tel.archives-ouvertes.fr/tel-00713567.

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La dégradation en solution aqueuse du 2-aminobenzothiazole (ABT) et du benzothiazole (BT) a été étudiée par voies photochimique, microbiologique et en combinant les deux approches. La voie photochimique impliquait des complexes aqueux de fer ou le complexe entre le fer et l'acide nitrilotriacétique (FeNTA). La voie microbiologique utilisait une souche bactérienne de Rhodococcus rhodochrous. Les schémas de dégradation ont été établis pour les différentes voies. Nous avons montré qu'il existait une grande similitude entre la dégradation photochimique et microbiologique. De plus, deux nouveaux pr
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15

Paranjpe, Shirish. "Synthesis of Novel Fluorescent Benzothiazole Cyanine Dyes as Potential Imaging Agents." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/chemistry_theses/55.

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Near-infrared (NIR) fluorescence imaging has emerged as an attractive non-invasive approach for direct visualization of diseases which depends on the development of stable, highly specific and sensitive optical probes. The NIR region of the electronic spectrum offers a reduction in the background autofluorescence and an increase in the tissue penetration depth. Cyanine dyes have often been considered promising contrast optic agents owing to their photophysical properties. Herein the synthesis of various penta- and heptamethine benzothiazole cyanine dyes has been described and their in vivo ima
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16

Willis, Kimberlee Susan. "Developing benzothiazole functionalised ruthenium(II) polypyridyl complexes as tuneable DNA binders." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675442.

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The aim of this research is to develop a range of new ruthenium(II) polypyridyl complexes to be analysed spectroscopically in the presence of calf thymus-DNA to determine their relative binding affinities to the polynucleotide, thus determining the best criteria for a detection tool for DNA. Reactions of selected functional groups on one ligand of ruthenium(II) precursor complexes lead to the synthesis of six benzothiazole containing complexes; [Ru(bpY)2(B16)]2+,, [Ru(bpy)2(P5)]2+, [Ru(phen)2(B16)]2+, [Ru (phenh(P5)]2+, [Ru(Me2bpY)2(B16)]2+ and [Ru(Me2bpy)2(P5)]2+ and four "control" complexes;
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17

Barbieru, Roxana Gabriela. "2H-1,4-Benzoxazin- und 2H-1,4-Benzothiazin-Derivate Synthese, Eigenschaften und Anwendung zu neuartigen Haarfärbemitteln /." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972095039.

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18

Li, Zhe. "Fluorinated zinc and erbium complexes based on benzothiazole derived ligands for optoelectronic devices." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8547.

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Three families of fluorinated ligands based on benzothiazole derivatives, including 2-(2-hydroxyphenyl)benzothiazoles, bis(benzothiazolyl)amines and N-benzothiazol- 2-yl-methanesulfonamides, have been synthesised with different locations and extents of fluorination. Zinc complexes of the fluorinated 2-(2-hydroxyphenyl)benzothiazoles and bis(benzothiazolyl)amines have been successfully prepared. Crystallographic characterisations of these zinc complexes have revealed various molecular packing behaviours in their crystals in terms of πH-πH, πH-πF and πF-πF stacking under the influence of partial
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19

Mansour, Oussama. "Conception et synthèse d'antagonistes benzodiazépiniques et benzothiazépiniques des récepteurs de l'endothéline." Université Joseph Fourier (Grenoble), 2000. http://www.theses.fr/2000GRE18009.

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20

Langille, Adrienne. "Synthesis and biological evaluation of 2- aminothiophene and benzothiazole derivatives as isoprenoid biosynthesis inhibitors." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117127.

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The condensation of stable 2-(1-(trimethylsilyl)ethylidene)malononitrile with elemental sulfur was explored in the parallel-synthesis of a small library of structurallydiverse2-aminothiophenesandthieno[2,3-d]pyrimidines. Bromination and ipso-iododesilylation of these heterocyclic scaffolds provided synthetic methods to efficiently generate key intermediates, allowing for great versatility. Bisphosphonic acid derivatives of thieno[2,3-d]pyrimidine and benzothiazole scaffolds, with favourable physicochemical properties, were evaluated for their ability to inhibit isoprenoid biosynthesis and pote
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21

Bi, Xiaoman bi. "Synthesis and Characterization of Novel Fluorescent Sensors Based on Terpyridine, Benzoxazole and Benzothiazole Chromophores." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1512743963248758.

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22

Hoang, Huong. "Hydroquinone-based Poly(arylene ether)s with Pendent Benzothiazole Or Benzoxazole and 3-sulfonated Phenyl Sulfonyl Groups for Use as Proton Exchange Membranes." Wright State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1376481513.

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23

Kemboi, Abraham K. "Design and Application of Facile Routes to N-Heterocycle Functionalized Poly(arylene ether)s." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1464120801.

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24

Genty, Axelle. "Synthèse stéréοsélective d’hétérοcycles azοtés par réactiοns mοnοtοpes dοminο". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMLH30.

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Les hétérocycles azotés sont particulièrement présents en chimie médicinale et pharmaceutique. Les δ-lactames, en particulier, connaissent un essor croissant en raison de leur fort intérêt biologique et de leur utilisation en tant qu'intermédiaires réactionnels pour la synthèse de molécules d'intérêt. L’étude croissante de ces composés conduit à une recherche de nouvelles voies de synthèse pour accéder à ces motifs polyfonctionnalisés. Les réactions monotopes se distinguent comme une stratégie privilégiée, permettant, en une seule étape, la formation de multiples liaisons et centres stéréogène
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25

Wrigley, Samantha. "Investigations of the subtle and selective antitumour properties of 2-(4-aminophenyl)-benzothiazole and related compounds." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338529.

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26

Zhang, Yang. "Study of Niternium Ions Derived from Anti-tumor Drugs." Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1452548713.

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27

Rached, Abdelouahed. "Hétérocycles dérivés de la théophylline, des indolizines, du thiazole, du benzothiazole et du benzimidazole : synthèse et étude pharmacologique." Toulouse, INPT, 1992. http://www.theses.fr/1992INPT055G.

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Apres une etude bibliographique des proprietes pharmacologiques et des methodes de synthese de la theophylline, l'auteur dans une premiere partie decrit une douzaine de theophylline originales substituees en 8 le plus souvent par des heterocycles oxygenes. L'etude pharmacologique in vitro a montre pour certains derives une activite superieure a celle de la theophylline. Une etude de modelisation permet d'envisager des composes encore plus actifs. Dans la deuxieme partie, l'auteur s'interesse a des phosphonates a visee inhibitrice calcique a structure voisine d'une theophylline de la premiere p
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28

Nezirevic, Dernroth Dzeneta. "Pheomelanin markers in melanoma with reference to their excretion into urine." Doctoral thesis, Linköpings universitet, Klinisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21486.

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Skin pigmentation is an important issue in most cultures. Until recently we have not understood the most important elements of pigmentation regarding detailed chemical structure. The synthesis of melanin is very complex, and although core enzymes, other important proteins, and parts of the melanin structure have been identified much information in this context awaits disclosure. The function of the melanocyte and the deposition of melanin pigments into the keratinocytes are very important in the protection against UV light. Melanin pigments consist of high-molecular structures often described
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29

DJUIDJE, ERNESTINE NICAISE. "Design, Synthesis and Biological activities of Benzothiazole, Benzimidazole and Imidazopyrimidine polyphenols as multifunctional molecules against oxidative stress sustained processes." Doctoral thesis, Università degli studi di Ferrara, 2018. http://hdl.handle.net/11392/2488156.

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Reactive oxygen species regulate several essential physiological processes such as cell proliferation, differentiation, vascular tone and inflammation. However, their higher concentrations can have deleterious effects on many molecules including protein, lipid, RNA and DNA which leads to cell destruction causing several diseases including Parkinson’s diseases, inflammatory disease, cardiovascular, cancer, diabetes, Alzheimer’s disease, cataracts, autism and aging. Most of these diseases involve more physiopathological indications. Nevertheless, different pharmacological strategies, such as the
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30

Selmi, Samia. "Synthèse, étude pharmacologique et relations structures activités (3D QSAR) des nouveaux dérivés du benzothiazole anti-HIV et anti Plasmodium falciparum." Aix-Marseille 3, 2007. http://www.theses.fr/2007AIX30049.

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Au cours de ce travail, nous avons réalisé une étude complète sur des composés benzothiazoles et ses dérivés. Nous avons mis au point et optimisée une stratégie de synthèse pour obtenir des nouveaux benzothiazoles substitués en position 2. Tous ces composés ont, par la suite, été testés au niveau de Plasmodium falciparum et du HIV. Les résultats des tests biologiques ont été validés par une étude de relation structure activité (3D QSAR), certains résultats sont encourageants et nous ont permis de proposer la synthèse des nouveaux benzothiazoles avec des activités pharmacologiques exacerbées<br
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31

Avellaneda, Antonio. "Synthèse et étude physico-chimique de nouveaux composés dérivés de l'acridine et du benzothiazole. Nouveaux monomères chiraux pour les matériaux mésogènes." Aix-Marseille 3, 2004. http://www.theses.fr/2004AIX30024.

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Les différentes synthèses développées dans ce manuscrit s'orientent vers deux interfaces majeures de la chimie organique, la chimie thérapeutique et les matériaux. Dans la partie A, nous présentons l'élaboration de nouvelles classes de molécules issues de l'association acridine - benzothiazole. Cette étude nous a permis de réaliser deux nouvelles familles de composés chimiques à but thérapeutique : les benzothiazol-2-yl-aminoacridones et les bis-thiazolo[5,4-a]acridines pontées en positions 2. Les résultats des premiers tests biologiques montrent notamment une activité antiparasitaire pour cer
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32

Mihaly, Joseph J. "SYNTHESIS AND PHOTOPHYSICS OF ORGANOGOLD COMPLEXES BEARING EITHER A BENZOTHIAZOLE FLUORENYL OR DIPHENYL AMINO FLUORENYL MOIETY: A STUDY IN STRUCTURE-PROPERTY RELATIONSHIPS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1593957001913688.

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33

Chakraborty, Mrinal. "Chemistry of the Putative Metabolite of a Model Anti-tumor Drug." Miami University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=miami1344305348.

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34

Pro, Danièle. "Développement de nouveaux inhibiteurs d’uréases et de la nitrification à des fins phytosanitaires." Rennes, Ecole nationale supérieure de chimie, 2011. http://www.theses.fr/2011ENCR0003.

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L’urée, apportée dans les engrais, fournit aux plantes l’azote nécessaire à leur croissance. Dans le sol, elle est convertie en ammoniac par les uréases, puis, via le procédé de nitrification, est oxydée en nitrites, puis en nitrates, éléments essentiels pour la nutrition des plantes. Mais, cet apport artificiel conduit à de nombreux déséquilibres écologiques dus à d’importants rejets d’azote au niveau atmosphérique et aquatique. C’est pourquoi les inhibiteurs d’uréases et de la nitrification, qui régulent la présence des différentes formes de l’azote dans le sol, sont d’un intérêt majeur en a
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35

Bahlaouan, Zineb. "Réactivité cupro-catalysée des systèmes mono, di et triiodés porteurs d'une fonction acide carboxylique ou dérivée : applications à la synthèse de nouveaux hétérocycles." Thesis, Tours, 2011. http://www.theses.fr/2011TOUR4035/document.

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Les hétérocycles oxygénés, azotés et soufrés sont des motifs présents dans de nombreux produits naturels possédant des activités biologiques intéressantes. Plusieurs publications décrivant la synthèse de ces hétérocycles en particulier oxygénés et azotés reposent sur l’utilisation des métaux de transition en tant que catalyseur.Dans notre cas, nous nous sommes intéressés dans un premier temps à la synthèse cupro-catalysée des pyrano[3’,4’:4,5]imidazo[1,2-a]pyridin-1-ones selon une réaction tandem impliquant un couplage et une hétérocyclisation, à partir des dérivés de l’acide 3-iodo-, 3,6- ou
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Jensen, Jordan Royce. "Development of Tau-Selective Imaging Agents for Improved Diagnosis of Alzheimer’s Disease and Other Tauopathies." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306441097.

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37

Cressier, Damien. "Synthèse et évaluation de nouveaux dérivés organiques et organométalliques contre les effets des rayonnements ionisants." Toulouse 3, 2010. http://thesesups.ups-tlse.fr/1027/.

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Ce travail s'inscrit dans un Programme d'Etudes Amont dont le but est la synthèse et l'évaluation de nouveaux composés organiques et organométalliques présentant des propriétés antioxydantes, radioprotectrices et radiosensibilisatrices dans un rapport activité/toxicité convenable. Nous avons ainsi réalisé la synthèse de nouveaux motifs dérivés de l'acide pulvinique, de l'acide salicylique, de la naphtyl-méthyl-imidazoline, du benzothiazole, du thiadiazole et des naphtalimides. Tous ces composés ont été caractérisés par spectroscopie RMN (1H, 13C, 31P), par spectrométrie de masse, analyse éléme
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Spadaro, Alessandro [Verfasser], and Rolf W. [Akademischer Betreuer] Hartmann. "Pharmacophore aided hit identification, structural optimization and biological evaluation of benzothiazole derivatives as new potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 / Alessandro Spadaro. Betreuer: Rolf W. Hartmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/1052338666/34.

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39

Heider, Silvio. "Synthese neuer tri- und hexadentater Stickstoffbasen für Eisen(II) Spin Crossover Komplexe." Doctoral thesis, Universitätsbibliothek Chemnitz, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-120783.

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Die vorliegende Arbeit thematisiert Eisen(II)-Komplexe mit Spinübergangseigenschaften. Dafür wurden neue hexadentate Liganden auf Basis von N,N'-Bis(2,2'-bipyridin-6-ylmethyl)-2,2'-biphenylendiamin entwickelt. Die in Kapitel 3.1 vorgestellten Systeme variieren dabei in den jeweiligen Substituenten der 6,6‘-Positionen der Biphenyleinheit. Es wird der Einfluss dieser Gruppen auf die magnetischen Eigenschaften der resultierenden Komplexe gezeigt. Im darauffolgenden Kapitel 3.2 wird ein variiertes Ligandensystem vorgestellt, in welchem anstelle einfacher Substituenten Donorfunktionen eingeführt wu
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40

Chang, Wei-Hsiang, and 張韋翔. "Synthesis of Benzothiazine and Thiochroman Derivatives." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/33112473435032408615.

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碩士<br>國立臺灣師範大學<br>化學系<br>103<br>The contents of this dissertation is divided into two parts summarizing the results based on the experimental works performed during the course of study. The first part is about the syntheses potential bioactive compounds such as benzothiazine derivatives from (2-formylphenyl) ethanethioate and dimer benzothiazine through a nucleophilic substitution reaction. In the second part, we developed an efficient method for the synthesis of thiochroman derivatives via DMAP catalyzed one pot reaction of (2-formylphenyl) ethanethioate and nitrostyrene derivatives in aceton
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41

Liu, Chih-Fa, та 劉誌發. "design and synthesis of quinazolinone and 1,2-benzothiazine 1,1-dioxide derivatives as potential selective α1A-adrenoceptor antagonists". Thesis, 2000. http://ndltd.ncl.edu.tw/handle/59531007520783388600.

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碩士<br>國立臺灣大學<br>藥學研究所<br>88<br>This study is aimed to synthesize two series of compounds, namely, substituted arylpiperazinyl benzothiazinone 1,1-dioxide (A) and substituted arylpiperazinyl quinazolinone (B) derivatives for evaluation of α1A adrenoceptor selectivity and are considered to be potential for treatment of benign prostatic hyperplasia (BPH). The synthesis of compounds in A series started from esterification of 3,4-dimethoxyphenyl acetic acid (25) in methanol with a catalytic amount of concentrated sulfuric acid to give 3,4-dimethoxy-1-(carbomethoxymethyl)benzene (26). T
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42

Chen, Shu-Shiun, and 陳樹勳. "Preparation of Thiazinone, Benzothiazinone and Tricyclic Benzothiazinone Compounds and Evaluation of Their Xanthine." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/02627303636099071397.

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碩士<br>台北醫學院<br>藥學研究所<br>87<br>In a previous study, we found that benzothiazinone compounds displayed a significant inhibition on xanthine oxidase in in vitro test. 2-Amino-4H-1,3-benzothiazin-4-one (BJ-6) (IC50 = 5.54μM, Ki = 5.12μM) and 4-oxo-4H-1,3-benzothiazinone-2-guanidine (TDW-1) (IC50 = 5.60μM, Ki = 19.47μM) are the representatives of this class. In this study, we prepared several thiazinone analogues, benzothiazinone analogues, and tricyclic benzothiazinones that are structurally related to the benzothiazinone in order to search for the pharmacophore for enzyme
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43

Hung, Cheng-Hsien, and 洪正憲. "Synthesis and photophysical studies of 2-(2’-aminophenyl)benzothiazole derivatives." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/45xg4c.

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LU, DA-WEN, and 呂大文. "OCULAR PHARMACOKINETICS AND PHARMACODYNAMICS OF 6-HYDROXYETHOXY-2-BENZOTHIAZOLE SULAONAMIDE." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/46748345086659795873.

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Tzeng, Yih-Jing, and 曾義鏡. "The study of 2-(2’-hydroxyphenyl) benzothiazole contained polymer electroluminescent devices." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/33287601617594815104.

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碩士<br>國立臺北科技大學<br>有機高分子研究所<br>91<br>In this study, single-layer polymer light-emitting devices using dye dispersed in polymer matrix are fabricated. 2-(2-Hydroxyphenyl) benzothiazole, HBT, is synthesized and used as the dopant in emissive polymer layer. Three types of polymer matrix are used, including MEH-PPV, PVK with DCJTB or Nile red. The devices have been fabricated in varied conditions on the metal cathode deposition, single or double layered device configuration, and varied spinning rates of polymer film deposition. The results of our experiments indicate a few interesting ph
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Lin, Young-Xiang, and 林永祥. "Synthesis and Emission Device Fabrication of Benzothiazole Contained Pendent PPV Polymers." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/62789296271572783813.

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碩士<br>國立臺北科技大學<br>有機高分子研究所<br>92<br>We present synthesis and characterization of benzothiazole contained pendent PPV polymers. In this study, polymers of MVBMEH-PPV(Ⅰ) and MVBBEH-PPV (Ⅱ) have been synthesized through the well - known Horner-Wadsworth-Emmons polycondensation reaction. The synthesized polymers were completely soluble in common organic solvent, such as THF, toluene and chloroform etc. The polymer devices of MVBMEH-PPV(Ⅰ) and MVBBEH-PPV(Ⅱ) have relative low turn-on voltage at 4.4 Volts and 8 Volts. The EL spectrum of MVBMEH-PPV (Ⅰ) and MVBBEH-PPV (Ⅱ) exhibits the emission peak at
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Lin, Chien-Cheng, and 林建成. "Design and Synthesis of Benzothiazole Derivatives Via Click Chemistry of Aryne." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/48000335763526706386.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>99<br>2-Phenylbenzothiazoles are known natural products with biological activity. The derivatives are potential anti-cancer activity inter breast、colon、ovarian and renal cell. The click chemistry applications are in the drug discovery, and also fast and practical synthetic method In this study, we use the aryne click chemistry to design and synthesis anti-human agent
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Ming-Chi-Lan and 藍啟銘. "Synthesis,characterization and physical properties of benzothiazole derivatives and ruthenium complex." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/c757wc.

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碩士<br>國立臺北科技大學<br>有機高分子研究所<br>95<br>This research is mainly the synthesis of benzothiazole derivatives and theirs rutheinum complexes. Benzothiazole derivatives were synthesized with higher yield by condensation reaction of carboxylic acid derivatives and 2-aminothiophenol where the polyphosphoric acid as a catalyst, providing an acidic environment. The resulting benzothiazole derivatives, didentate (L2) and tridentate (L3) and 4,4’-dicarboxy- 2,2’-bipyridine (dcbpy) were acted as ligands to react with RuCl3·H2O to form novel ruthenium complexes [Ru(dcbpy)(L3)Cl].and [Ru(dcbpy)( L2)Cl2]. Ch
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Wang, Po-lung, and 王伯隆. "Synthesis and Characterization of New Polybenzimidazoles Containing Pendent Benzimidazole or Benzothiazole Groups." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/19015831577161375792.

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碩士<br>國立臺灣科技大學<br>化學工程系<br>102<br>Part I A series of new polybenzimidazoles (PBIs) with pendant benzimidazole ring had been synthesized. This is the first study that improved mechanical properties of proton exchange membranes via crosslinking reaction using methyl pendent. The uncrosslinked PBI showed good solubility in aprotic solvents. They had high inherent viscosities in the range of 0.9~1.21 dLg-1, and they could form tough and flexible films. After crosslinking, they exhibited high thermal stability and their glass transition temperature exceeded 300oC. The PBI had the high tensile stres
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Su, Chi-Sheng, and 蘇琪勝. "Synthesis and Biological Evaluation of 1,3-Benzothiazinone Derivatives In Cell Protective Activities." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/52363622575154282269.

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碩士<br>臺北醫學大學<br>藥學研究所<br>96<br>Neurodegenerative diseases such as Alzheimer’s Disease, Parkinson’s Disease, and Stroke are common diseases of neuronal damage. It has been reported that these kind of damage might be protected by the maintance of astrocytes. On the contrary, diseases caused astrocyte damage or apoptosis would result in it’s loss in neuro- protective activities, even cause neuron damage and cell apoptosis. Which could be one of the mechanisms of neurodegenerative diseases. As a result, astrocytes protection might be a route for neuroprotection. Many researches have been reported
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