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Journal articles on the topic 'Benzothiazol'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Višņevska, J., E. Jaščenko, I. Šestakova, A. Gulbe, and E. Ābele. "Unusual Synthesis and Cytotoxicity of N-[2-(Benzothiazol-2-Sulfonyl)-1-Ethoxyethoxy]- 5-(Benzothiazol-2-Ylsulfanyl)Pentanamidine." Latvian Journal of Chemistry 51, no. 1-2 (2012): 149–53. http://dx.doi.org/10.2478/v10161-012-0003-1.

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Unusual Synthesis and Cytotoxicity of N-[2-(Benzothiazol-2-Sulfonyl)-1-Ethoxyethoxy]- 5-(Benzothiazol-2-Ylsulfanyl)PentanamidineAddition of N-hydroxy-5-(benzothiazolylthio)pentanamidine toE-2-(2-chlorovinylsulfonyl)benzothiazole in the presence of NaH was studied. The main product of reaction - N-[2-(benzothiazol-2-sulfonyl)-1-ethoxyethoxy]-5-(benzothiazol-2-ylsulfanyl)pentanamidine exhibits high cytotoxicity.

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2

Arafat, Mahmoud, Ehab Abdel-Latif, Fathy M. El-Taweel, Seif-Eldin N. Ayyad, and Khaled S. Mohamed. "Synthesis and biological assessment of new benzothiazolopyridine and benzothiazolyl- triazole derivatives as antioxidant and antibacterial agents." Bulletin of the Chemical Society of Ethiopia 36, no. 2 (2022): 451–63. http://dx.doi.org/10.4314/bcse.v36i2.17.

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ABSTRACT. A novel series of benzothiazolopyridine derivatives was synthesized via interaction of -2-(benzothiazol-2-yl)-3-(4-chlorophenyl)acrylonitrile (2) with a diverse of commercially available reagents (indandione, thiobarbituric acid, and malononitrile). Moreover, a novel group of benzothiazole linked substituted 1,2,3-triazole derivatives were synthesized by exploring the chemical behavior of 5-benzothiazolyl-2-(4-chlorophenyl)-triazol-4-amine through refluxing in glacial acetic acid, condensation with phthalic anhydride, and cyanoacetylation reactions. All newly synthetized compounds ha

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3

K. Jassim, Ibtisam, Sawsan S. Harth, Rua M. Dhedan, and Ali Obais Abd. "Synthesis and study the biological activity of some six, five and fused ring heteroatome systems derived from 2-mercapto benzothiazole." Tikrit Journal of Pharmaceutical Sciences 8, no. 1 (2023): 96–105. http://dx.doi.org/10.25130/tjphs.2012.8.1.12.96.105.

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In this paper ,new series of 2-hydrazino benzothiazole [1], 2-N-benzothiazole-N`-phenyl hydrazine carboxamide [2], 2-N-[(3)-N`-phenyl-5-(p-bromophenyl)-2`-hydroxy-1,3-oxazolin-2`-yl] benzothiazol hydrazine [3] , 2-N-benzothiazole-N`-1-naphthyl hydrazine carboxamide [4], 2-N-[(3`)-N`-(1-naphthyl)-5`-(p-bromo phenyl)-2`-hydroxy-1,3-oxazolin-2`-yl)] benzothiazol hydrazine [5], of 2-thiaacetic acid benzothiazole [6] ,2-thiaacetyl chloride benzothiazole [7], 5-amino-2-mercapto-1,3,4-thiadiazole [8], of 2-mercapto-[5-acetamid thiamethyl benzothiazol]-1,3,4-thiadiazole [9], 2-phenyl-5-chloromethyl-1,

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4

P., ANITHA, SRIDEVI G., and KONDAL REDDY K. "Synthesis of 1-Benzothiazol-2-yl-2-arylimino-striazolo [ 5, 1-b ]benzothiazoles." Journal of Indian Chemical Society Vol. 72, Apr 1995 (1995): 257–59. https://doi.org/10.5281/zenodo.5902215.

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Department of Chemistry, Osmania University, Hyderabad-500 007 <em>Manuscript received 19 October 1993, accepted 20 December 1993</em> <em>N</em>-Aryl-<em>N',N"</em>-bis(benzothiazol-2-yl)guanidines have been obtained by the reaction of <em>N</em>-aryl-<em>N'</em>-benzothiazol-2-ylthioureas (1) with lead oxide. Oxidative cyclisation of N-aryl-<em>N'</em> ,<em>N"</em>-bis(benzothiazol-2-yl)guanidines (2) by lead tetraacetate led to the formation of 1-benzothiazol-2-yl-2-arylimino-s-triazolo[5,1-b]benzothiazoles (5).

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5

Anuba, C., and T. F. Abbs Fen Reji. "Synthesis, Characterization and Biological Activities of Substituted 1-[Benzothiazol-(1H)-2-yl]-3-phenyl-prop-2-en-1-ones." Asian Journal of Organic & Medicinal Chemistry 4, no. 3 (2019): 144–46. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p181.

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A series of ortho and para substituted 1-[benzothiazol-(1H)-2-yl]-3-phenyl-prop-2-en-1-one derivatives were synthesized from 2-acetyl benzothiazole and ortho and para-substituted benzaldehye using ethanol as solvent. The synthesized compounds were characterized by UV-visible, FT-IR, 1H NMR and mass spectrometry. Antioxidant activities of synthesized compounds have been evaluated by DPPH free radical scavenging activity using ascorbic acid as standard. The standard solution and 1-[benzothiazol- (1H)-2-yl]-3-phenylprop-2-en-1-ones compounds were prepared with different concentrations. Anticancer

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6

Yavari, Issa, Kiyana Ghafouri, Maryam Naeimabadi, and Mohammad Halvagar. "A Synthesis of Functionalized 2-Indolizin-3-yl-1,3-benzothiazoles from 1-(1,3-Benzothiazol-2-ylmethyl)pyridinium Iodide and Acetylenic Esters." Synlett 29, no. 02 (2017): 243–45. http://dx.doi.org/10.1055/s-0036-1590910.

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Functionalized 2-indolizin-3-yl-1,3-benzothiazoles were obtained in moderate yields from the reaction between 1-(1,3-benzothiazol-2-ylmethyl)pyridinium iodide and acetylenic esters in acetonitrile. When isoquinoline was used under similar conditions, dialkyl 3-(1,3-benzothiazol-2-yl)pyrrolo[2,1-a]isoquinoline-1,2-dicarboxylates were obtained. The structures of these products have been confirmed by X-ray diffractometry.

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7

Amosova, Svetlana V., Vladimir A. Shagun, Nataliya A. Makhaeva, Irina A. Novokshonova, and Vladimir A. Potapov. "Quantum Chemical and Experimental Studies of an Unprecedented Reaction Pathway of Nucleophilic Substitution of 2-Bromomethyl-1,3-thiaselenole with 1,3-Benzothiazole-2-thiol Proceeding Stepwise at Three Different Centers of Seleniranium Intermediates." Molecules 26, no. 21 (2021): 6685. http://dx.doi.org/10.3390/molecules26216685.

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The results of quantum chemical and experimental studies of the reaction of 2-bromomethyl-1,3-thiaselenole with 1,3-benzothiazole-2-thiol made it possible to discover the unprecedented pathway of this reaction, which proceeds stepwise at three different centers of seleniranium intermediates. The first stage includes an attack of thiolate anion at the selenium atom of the seleniranium cation accompanied by ring opening with the formation of (Z)-2-[(1,3-benzothiazol-2-ylsulfanyl)selanyl]ethenyl vinyl sulfide, which is converted to six-membered heterocycle, 2-(2,3-dihydro-1,4-thiaselenin-2-ylsulf

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8

Lystsova, Ekaterina A., Alexander S. Novikov, Maksim V. Dmitriev, Andrey N. Maslivets, and Ekaterina E. Khramtsova. "Approach to Pyrido[2,1-b][1,3]benzothiazol-1-ones via In Situ Generation of Acyl(1,3-benzothiazol-2-yl)ketenes by Thermolysis of Pyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones." Molecules 28, no. 14 (2023): 5495. http://dx.doi.org/10.3390/molecules28145495.

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Acyl(imidoyl)ketenes are highly reactive heterocumulenes that enable diversity-oriented synthesis of various drug-like heterocycles. Such ketenes, bearing heterocyclic substituents, afford angularly fused pyridin-2(1H)-ones in their [4+2]-cyclodimerization reactions. We have utilized this property for the development of a new synthetic approach to pharmaceutically interesting pyrido[2,1-b][1,3]benzothiazol-1-ones via the [4+2]-cyclodimerization of acyl(1,3-benzothiazol-2-yl)ketenes generated in situ. The thermal behaviors of 3-aroylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones and 3-benzoylpy

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9

Dai, Yanling, Chen Xie, Lingmin Wu, et al. "Asymmetric synthesis of amino-benzothiazol derivatives by additions of 2-lithiated benzothiazoles to (S)-N-t-butylsulfinyl-ketimines." RSC Advances 5, no. 5 (2015): 3491–97. http://dx.doi.org/10.1039/c4ra15405c.

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We reported the asymmetric Mannich reactions between lithium-benzothiazoles and (S)-N-tert-butanesulfinylketimines, which gave unknown type of amino-benzothiazol derivatives of high pharmaceutical potential with up to 96% yields and 99 : 1 diastereoselectivities.

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10

Zhang, Chao, Juan Xu, Xinyu Zhao, and Congmin Kang. "Synthesis of Novel 3-(Benzothiazol-2-Ylmethylene)Indolin-2-Ones." Journal of Chemical Research 41, no. 9 (2017): 537–40. http://dx.doi.org/10.3184/174751917x15040891974776.

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A mild method for the synthesis of 3-(benzothiazol-2-ylmethylene)indolin-2-ones via the aldol condensation of substituted indolin-2-ones and benzothiazole-2-carbaldehyde is described. This new procedure has significant advantages, such as mild conditions, high yields and simple work-up.

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11

Dhakoniya, Pallavi. "Synthesis and Characterization of Benzylidene Derivatives of Benzothiazole." International Journal for Research in Applied Science and Engineering Technology 9, no. VIII (2021): 506–11. http://dx.doi.org/10.22214/ijraset.2021.37370.

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A series of some novel benzothiazole derivatives were synthesized from the 2-(4-aminophenyl) benzothiazol-5-ol, which was synthesized by the Jacobson method using Lawesson’s reagent. Benzylidene derivatives (P201-P205) were synthesized by catalyzed condensation and acylation method,named as 2-(4-((4 hydroxybenzylidene)amino) phenyl) benzothiazole-5-ol (P201), 2-(4-((4- methoxybenzylidene) amino)phenyl)benzothiazole-5ol(P202),2-(4-((4-chlorobenzylidene) amino)phenyl)benzothiazole-5-ol(P203), (4-((furan-2-ylmethylene) amino)phenyl)benzothiazole-5-ol(P204), Dimethyl(4(5hydroxy benzothiazol2yl)phe

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12

Lamkane, Rachana B., Priyanka M. Khadasare, Pooja M. Shinde, et al. "Synthesis and Biological Screening of Novel Derivatives of Benzothiazol as Anticonvulsant Agents." SAR Journal of Medical Biochemistry 4, no. 01 (2023): 6–15. http://dx.doi.org/10.36346/sarjmb.2023.v04i01.002.

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The Benzothiazole ring system belongs to a much studied class of compound. In the last few decades, the chemistry of benzothiazole and their fused heterocyclic derivatives have received considerable attention owing to their significant and effective biological activity. The present study aimed to design and synthesize novel derivatives of bezothiazole obtained from 3-chloro-4-flouro aniline treated with potassium thiocynide with chloro acetyl chloride gives (7-chloro-6-fluro-1,3-benzothiazol-2-yl) acetyl chloride which is converted into hydrazide and yields the resultant compound derivatives o

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13

Schroeder, Zachary W., L. K. Hiscock, and Louise Nicole Dawe. "Copper(II)- and gold(III)-mediated cyclization of a thiourea to a substituted 2-aminobenzothiazole." Acta Crystallographica Section C Structural Chemistry 73, no. 11 (2017): 905–10. http://dx.doi.org/10.1107/s205322961701381x.

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Benzothiazole derivatives are a class of privileged molecules due to their biological activity and pharmaceutical applications. One route to these molecules is via intramolecular cyclization of thioureas to form substituted 2-aminobenzothiazoles, but this often requires harsh conditions or employs expensive metal catalysts. Herein, the copper(II)- and gold(III)-mediated cyclizations of thioureas to substituted 2-aminobenzothiazoles are reported. The single-crystal X-ray structures of the thiourea N-(3-methoxyphenyl)-N′-(pyridin-2-yl)thiourea, C13H13N3OS, and the intermediate metal complexes aq

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14

Nayak, Janardhana, and Ramesh S. Bhat. "Synthesis, Antimicrobial and Corrosion Inhibition Studies of 1,3-Benzothiazole Derivatives." Asian Journal of Chemistry 35, no. 2 (2023): 375–78. http://dx.doi.org/10.14233/ajchem.2023.26885.

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With an emphasis on potential medicinal and corrosion inhibition applications, four N-(4-(substituted benzylidene)benzo[d]thiazol-2-amine were synthesized by the condensation of 2,3-dihydro-1,3- benzothiazol-2-amine with 4-substituted benzaldehydes. Nuclear magnetic resonance (NMR), infrared (IR) and mass spectroscopy were used to characterize the synthesized compounds. To assess the antibacterial activity of synthetic drugs, the conventional serial dilution approach has been used. The synthesized compounds showed excellent bioactivities comparable to those of a typical medication. The corrosi

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15

Alsarahni, Aseel, Zuhair Muhi Eldeen, Elham Al-kaissi, Ibrahim Al- Adham, and Najah Al-muhtaseb. "SYNTHESIS AND STRUCTURAL ELUCIDATION OF AMINO ACETYLENIC AND THIOCARBAMATES DERIVATIVES FOR 2-MERCAPTOBENZOTHIAZOLE AS ANTIMICROBIAL AGENTS." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 2 (2017): 192. http://dx.doi.org/10.22159/ijpps.2017v9i2.15760.

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<p><strong>Objective: </strong>To design and synthesize amino acetylenic and thiocarbonate of 2-mercapto-1,3-benthiazoles as potential antimicrobial agents.</p><p><strong>Methods: </strong>A new series of 2-{[4-(t-amino-1-yl) but-2-yn-1-yl] sulfanyl}-1,3-benzothiazole derivatives (AZ1-AZ6), and S-1,3-benzothiazol-2-yl-O-alkyl carbonothioate derivatives were synthesised, with the aim that the target compounds show new and potential antimicrobial activity. The elemental analysis was indicated by the EuroEA elemental analyzer, and biological characterizat

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16

Azam, Mohammed Afzal, Loganathan Dharanya, Charu Chandrakant Mehta, and Sumit Sachdeva. "Synthesis and biological evaluation of some novel pyrazolopyrimidines incorporating a benzothiazole ring system." Acta Pharmaceutica 63, no. 1 (2013): 19–30. http://dx.doi.org/10.2478/acph-2013-0001.

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In the present study, a series of benzothiazol derivatives 3a-l containing pyrazolo[3,4-d]pyrimidine moiety at the second position were synthesized and characterized by analytical and spectral data. The compounds were tested for their in vitro antimicrobial activity. Compounds 1-(1,3-benzothiazol-2- yl)-3-methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine (3a), 1- (1,3-benzothiazol-2-yl)-4-(4-chlorophenyl)-3-methyl-1H-pyrazolo[ 3,4-d]pyrimidine (3d) and 1-(1,3-benzothiazol-2-yl)- 3-methyl-4-substituted phenyl-1H-pyrazolo[3,4-d]pyrimidines (3h-j) showed significant inhibitory activity against P. aeru

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17

Monopoli, Antonio, Pietro Cotugno, Carlo Giorgio Zambonin, Francesco Ciminale, and Angelo Nacci. "Highly selective palladium–benzothiazole carbene-catalyzed allylation of active methylene compounds under neutral conditions." Beilstein Journal of Organic Chemistry 11 (June 10, 2015): 994–99. http://dx.doi.org/10.3762/bjoc.11.111.

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The Pd–benzothiazol-2-ylidene complex I was found to be a chemoselective catalyst for the Tsuji–Trost allylation of active methylene compounds carried out under neutral conditions and using carbonates as allylating agents. The proposed protocol consists in a simplified procedure adopting an in situ prepared catalyst from Pd2dba3 and 3-methylbenzothiazolium salt V as precursors. A comparison of the performance of benzothiazole carbene with phosphanes and an analogous imidazolium carbene ligand is also proposed.

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18

Kheder, Nabila A., Yahia N. Mabkhot, Fawzia R. Zahian, and Sara S. Mohamed. "Regioselective Synthesis of Some Pyrazole Scaffolds Attached to Benzothiazole and Benzimidazole Moieties." Journal of Chemistry 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/581721.

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Condensation of 2-(benzothiazol-2-yl)acetonitrile (1) or 2-(1-methyl-1H-benzimidazol-2-yl)acetonitrile (2) with thiophene-2-carbaldehyde afforded the corresponding acrylonitrile derivatives3or4, respectively. The 1,3-dipolar cycloaddition reaction of the acrylonitrile3or4with nitrile-imine6gave novel pyrazole derivatives pendant to benzothiazole and benzimidazole. The pyrazoline derivative7was converted into the corresponding pyrazole derivative11via thermal elimination of hydrogen cyanide upon heating in sodium ethoxide solution. The structures of the synthesized products were confirmed by IR

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19

Delmas, Florence, Carole Di Giorgio, Maxime Robin, et al. "In Vitro Activities of Position 2 Substitution-Bearing 6-Nitro- and 6-Amino-Benzothiazoles and Their Corresponding Anthranilic Acid Derivatives against Leishmania infantum and Trichomonas vaginalis." Antimicrobial Agents and Chemotherapy 46, no. 8 (2002): 2588–94. http://dx.doi.org/10.1128/aac.46.8.2588-2594.2002.

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ABSTRACT 6-Nitro- and 6-amino-benzothiazoles bearing different chains in position 2 and their corresponding anthranilic acid derivatives were investigated for their in vitro antiparasitic properties against parasites of the species Leishmania infantum and Trichomonas vaginalis compared to their toxicity towards human monocytes. Biological investigations established that the antiprotozoal properties depended greatly on the chemical structure of the position 2 substitution-bearing group. Compound C1, 2-[(2-chloro-benzothiazol-6-yl) amino] benzoic acid, demonstrated an interesting antiproliferati

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20

Bhatt, Keyur D. "Synthesis, Characterization and Biological Screening of Schiff bases derived from 4, 6-difluoro-2-amino Benzothiazole." Medicinal and Analytical Chemistry International Journal 4, no. 1 (2020): 1–7. http://dx.doi.org/10.23880/macij-16000157.

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Novel benzothiazole Schiff bases namely N-(4-chlorobenzylidene)-4,6-difluorobenzothiazole-2-amine; 4,6-difluoro-N-(4- nitrobenzylidene)benzothiazol-2-amine and N-((1H-indol-3-yl)methylene)-4,6-difluorobenzothiazole-2-amine have been synthesized from condensation reaction of 4,6-difluoro-2-amino benzothiazole with different aromatic aldehydes like 4-chlorobenzaldehyde, 4-nitrobenzaldehyde and 1H-indole-3-cardaldehyde. The structures of all the compounds were characterized by elemental analysis, FT-IR, Mass and 1 H-NMR spectroscopy. Schiff bases have been screened for antimicrobial activity agai

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21

Pilotzi-Xahuentitla, Hugo, Gabriela Canche-Naal, Rolffy Ortiz-Andrade, Gabriel Navarrete-Vázquez, and Emanuel Hernández-Núñez. "N-(Benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)amino)butanamide." Molbank 2024, no. 3 (2024): M1854. http://dx.doi.org/10.3390/m1854.

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Benzazoles, such as benzoxazoles and benzothiazoles, are compounds with important biological and pharmacological activities and important intermediaries in synthesis. This report presents the synthesis of a butanamide derived from linking 5-chloro-2-aminobenzoxazole and 2-aminobenzothiazole via 4-chlorobutanoyl chloride. The corresponding compound N-(benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)aminobutanamide was obtained at a 76% global yield using accessible starting materials and a methodology in two reaction steps. Furthermore, we conducted docking studies of this compound on 3-TOP prot

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22

Zangouei, Mahdieh, and Abbas Ali Esmaeili. "One-pot, catalyst-free synthesis of novel spiro[indole-3,4′-pyrano[2′,3′:4,5]pyrimido [2,1-b][1,3]benzothiazole] derivatives." Journal of Chemical Research 44, no. 11-12 (2020): 646–52. http://dx.doi.org/10.1177/1747519820916926.

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The present report describes one-pot three-component condensation of isatins, malononitrile, and 2-hydroxy-4 H-pyrimido[2,1- b][1,3]benzothiazol-4-one in water–ethanol mixture at reflux to develop an efficient one-pot protocol for the synthesis of novel spiro[indole-3,4′-pyrano[2′,3′:4,5]pyrimido[2,1- b][1,3]benzothiazole] derivatives. The significant features of this protocol are short reaction times, avoidance of toxic catalysts, and provision of excellent yields, no column chromatographic purification, and use of ethanol-water as an environmentally benign solvent. The molecular structure of

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23

Morscher, Alexandra, Marcus V. N. de Souza, James L. Wardell, and William T. A. Harrison. "Expected and unexpected products of reactions of 2-hydrazinylbenzothiazole with 3-nitrobenzenesulfonyl chloride in different solvents." Acta Crystallographica Section E Crystallographic Communications 74, no. 5 (2018): 673–77. http://dx.doi.org/10.1107/s2056989018005595.

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The syntheses and crystal structures of 2-[2-(propan-2-ylidene)hydrazinyl]-1,3-benzothiazol-3-ium 3-nitrobenzenesulfonate (C10H12N2S+·C6H4NO5S−), (I), 2-[2-(3-nitrobenzenesulfonyl)hydrazinyl]-1,3-benzothiazole (C13H10N4O4S2), (II) and 2-[2-(3-nitrobenzenesulfonyl)hydrazinyl]-1,3-benzothiazol-3-ium 3-nitrobenzenesulfonate (C13H11N4O4S2 +·C6H4NO5S−), (III) are reported. Salt (I) arose from an unexpected reaction of 2-hydrazinylbenzothiazole with the acetone solvent in the presence of 3-nitrobenzenesulfonyl chloride, whereas (II) and (III) were recovered from the equivalent reaction carried out i

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24

Wang, Gui-Xian, and Qi-Wei Zhang. "1,3-Benzothiazol-2(3H)-one–1,3-benzothiazole-2(3H)-thione (1/1)." Acta Crystallographica Section E Structure Reports Online 62, no. 8 (2006): o3168—o3169. http://dx.doi.org/10.1107/s1600536806024664.

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25

Rosales Hernández, Martha Cecilia, Marycruz Olvera-Valdez, Jazziel Velazquez Toledano, Jessica Elena Mendieta Wejebe, Leticia Guadalupe Fragoso Morales та Alejandro Cruz. "Exploring the Benzazoles Derivatives as Pharmacophores for AChE, BACE1, and as Anti-Aβ Aggregation to Find Multitarget Compounds against Alzheimer’s Disease". Molecules 29, № 19 (2024): 4780. http://dx.doi.org/10.3390/molecules29194780.

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Despite the great effort that has gone into developing new molecules as multitarget compounds to treat Alzheimer’s disease (AD), none of these have been approved to treat this disease. Therefore, it will be interesting to determine whether benzazoles such as benzimidazole, benzoxazole, and benzothiazole, employed as pharmacophores, could act as multitarget drugs. AD is a multifactorial disease in which several pharmacological targets have been identified—some are involved with amyloid beta (Aβ) production, such as beta secretase (BACE1) and beta amyloid aggregation, while others are involved w

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26

Modrzejewska, Julia, Marcin Szala, Aleksandra Grzelakowska, Małgorzata Zakłos-Szyda, Jacek Zielonka, and Radosław Podsiadły. "Novel Boronate Probe Based on 3-Benzothiazol-2-yl-7-hydroxy-chromen-2-one for the Detection of Peroxynitrite and Hypochlorite." Molecules 26, no. 19 (2021): 5940. http://dx.doi.org/10.3390/molecules26195940.

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Derivatives of coumarin, containing oxidant-sensitive boronate group, were recently developed for fluorescent detection of inflammatory oxidants. Here, we report the synthesis and the characterization of 3-(2-benzothiazolyl)-7-coumarin boronic acid pinacol ester (BC-BE) as a fluorescent probe for the detection of peroxynitrite (ONOO–), with high stability and a fast response time. The BC-BE probe hydrolyzes in phosphate buffer to 3-(2-benzothiazolyl)-7-coumarin boronic acid (BC-BA) which is stable in the solution even after a prolonged incubation time (24 h). BC-BA is slowly oxidized by H2O2 t

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27

Altaf, Muhammad, and Helen Stoeckli-Evans. "1,3-Benzothiazol-2-amine." Acta Crystallographica Section E Structure Reports Online 65, no. 8 (2009): o1894. http://dx.doi.org/10.1107/s1600536809027561.

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28

Hussein, Waleed M., and Ross P. McGeary. "Use of Ethyl (Benzothiazol-2-ylsulfonyl)acetate for Malonic Ester-type Syntheses of Carboxylic Acids and Esters." Australian Journal of Chemistry 67, no. 9 (2014): 1222. http://dx.doi.org/10.1071/ch14085.

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A new methodology for the synthesis of substituted carboxylic acids is described. Alkylation of either ethyl (benzothiazol-2-ylsulfonyl)acetate or ethyl 2-(benzothiazol-2-ylsulfonyl)propionate was achieved with alkyl halides and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in dichloromethane solution. These products were then desulfinated and hydrolysed in one-pot under mild conditions to give substituted acetic acids in good-to-excellent yields.

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29

Mahran, Mona, Samia William, Fatem Ramzy, and Amira Sembel. "Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents." Molecules 12, no. 3 (2007): 622–33. http://dx.doi.org/10.3390/12030622.

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A series of benzothiazol-2-yl-dithiocarbamates 3a-d along with their copper complexes 4a-c were synthesized via the reaction of suitable alkyl, aralkyl or heteroaryl halides with the sodium salt of benzothiazol-2-yl-dithiocarbamic acid, followed by complexation with copper sulphate. N-(4-Acetyl-5-aryl-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-benzothiazol-2-yl-acetamides 7a-c were synthesized by cyclization of the appropriate thiosemicarbazones 6a-c in acetic anhydride. Selected compounds were screened for in vitro schistosomicidal activity against Schistosoma mansoni at three different dosage leve

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Chhalodia, Anuj Kumar, Jan Rinkel, Dorota Konvalinkova, Jörn Petersen, and Jeroen S. Dickschat. "Identification of volatiles from six marine Celeribacter strains." Beilstein Journal of Organic Chemistry 17 (February 11, 2021): 420–30. http://dx.doi.org/10.3762/bjoc.17.38.

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The volatiles emitted from six marine Rhodobacteraceae species of the genus Celeribacter were investigated by GC–MS. Besides several known compounds including dimethyl trisulfide and S-methyl methanethiosulfonate, the sulfur-containing compounds ethyl (E)-3-(methylsulfanyl)acrylate and 2-(methyldisulfanyl)benzothiazole were identified and their structures were verified by synthesis. Feeding experiments with [methyl-2H3]methionine, [methyl-13C]methionine and [34S]-3-(dimethylsulfonio)propanoate (DMSP) resulted in the high incorporation into dimethyl trisulfide and S-methyl methanethiosulfonate,

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31

Shaibah, Mohammed A. E., Belakavadi K. Sagar, Hemmige S. Yathirajan, David B. Cordes, Alexandra M. Z. Slawin, and William T. A. Harrison. "Hydrogen-bonded molecular salts of reduced benzothiazole derivatives with carboxylates: a robust R_{2}^{2}(8) supramolecular motif (even when disordered)." Acta Crystallographica Section E Crystallographic Communications 75, no. 2 (2019): 167–74. http://dx.doi.org/10.1107/s2056989018018224.

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The syntheses and structures of five molecular salts of protonated 4,4,7,7-tetramethyl-3a,5,6,7a-tetrahydrobenzothiazol-2-ylamine (C11H19N2S+) with different deprotonated carboxylic acids (4-methylbenzoic acid, 4-bromobenzoic acid, 3,5-dinitrobenzoic acid, fumaric acid and succinic acid) are reported, namely 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium 4-methylbenzoate, C11H19N2S+·C8H7O2 −, (I), 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium 4-bromobenzoate, C11H19N2S+·C7H4BrO2 −, (II), 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothia

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J., A. Patel, D. Mistry B., and R. Desai K. "Synthesis of some novel 4-thiazolidinone compounds and their application as potential antimicrobial agent." Journal of Indian Chemical Society Vol. 83, Oct 2006 (2006): 1041–43. https://doi.org/10.5281/zenodo.5831373.

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Department of Chemistry, B. K. M. Science College, Valsad-396 001, Gujarat, India <em>Manuscript received 14 July 2005, revised 4 January 2006, accepted 28 June 2006</em> 3-Chloro-1-[5' -hydroxy-2' -(phenyldiazenyl) phenyll-4-[2" -hydroxy-5" -(1<em>"' </em>,3<em>'"</em> -benzothiazol-2<em>"'</em> -yl-diazenyl)phenyl)-2-azetidinone (4a-p),3-[5'-hydroxy-2'-(phenyldiazenyl)phenyl]-2-[2" -hydrox)·-5" -(1"' ,3'" -benzothiazol-2"' -yl-diazenyl) phenyl)- 4-thiazolidinone (Sa-p) and 3-[5' -hydroxy-2&#3

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Yousuf, Sammer, Hina Siddiqui, Rabia Farooq, and M. Iqbal Choudhary. "2-[3-(1,3-Benzothiazol-2-yl)-2,2-dimethylpropyl]-2-methyl-2,3-dihydro-1,3-benzothiazole." Acta Crystallographica Section E Structure Reports Online 68, no. 8 (2012): o2349. http://dx.doi.org/10.1107/s1600536812029297.

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In the title compound, C20H22N2S2, the five-membered thiazole ring of the 2-methyl-2,3-dihydro-1,3-benzothiazole unit has an envelope conformation. The dihedral angle between the planar [maximum deviation of 0.014 (1) Å for the S atom] benzothiazole ring system and the benzene ring is 78.37 (12)°. Two intramolecular C—H...S hydrogen bonds are observed, forming rings of graph-set motifS(6). In the crystal, the molecules are consolidated in pairs through N—H...N hydrogen bonds and are arranged parallel to thebaxis.

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Korotkikh, N. I., A. F. Aslanov, and O. P. Shvaika. "Recyclization reactions. Synthesis of 3-(2,3-epithiopropyl)-benzothiazol-2-one from 2-(allylthio)benzothiazole." Chemistry of Heterocyclic Compounds 26, no. 6 (1990): 716–17. http://dx.doi.org/10.1007/bf00756441.

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35

Ahmad, Samir M., Bruno B. C. Calado, Mariana N. Oliveira, Nuno R. Neng, and J. M. F. Nogueira. "Bar Adsorptive Microextraction Coated with Carbon-Based Phase Mixtures for Performance-Enhancement to Monitor Selected Benzotriazoles, Benzothiazoles, and Benzenesulfonamides in Environmental Water Matrices." Molecules 25, no. 9 (2020): 2133. http://dx.doi.org/10.3390/molecules25092133.

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In the present work we propose, for the first time, bar adsorptive microextraction coated with carbon-based phase mixtures, followed by microliquid desorption and high performance liquid chromatography-diode array detection (BAμE-μLD/HPLC-DAD) analysis, to enhance the performance of the determination of traces of benzotriazoles (BTRs), benzothiazoles (BTs), and benzenesulfonamide derivatives (BSDs) in environmental water matrices. Assessing six carbon-based sorbents (CA1, CN1, B test EUR, SX PLUS, SX 1, and R) with different selectivity properties allowed us to tailor the best phase mixture (R

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Al-Soud, Yaseen A., Haitham H. Al-Sa’doni, Sadeekah O. W. Saber, Reem H. M. Al-Shaneek, Najim A. Al-Masoudi, and P. La Colla. "Synthesis, in vitro Antiproliferative and Anti-HIV Activity of New Derivatives of 2-Piperazino-1,3-benzo[d]thiazoles." Zeitschrift für Naturforschung B 65, no. 11 (2010): 1372–80. http://dx.doi.org/10.1515/znb-2010-1113.

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A series of N-{2-oxo-2-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]}-(het)arenecarboxamides 4a - l, sulfonamide derivatives 8a - i as well as benzothiazole-containing N1-(2-oxoethyl)-N1-arylthioureas 9a - c have been synthesized. Compounds 4a - l and 9a were evaluated, in vitro, for their antiproliferative activity against a large panel of human tumor-derived cell lines. Compounds 4l and 9a were the most potent analogs in this series, showing remarkable effects on human splenic B-lymphoblastoid cells (WIL-2NS) and human acute B-lymphoblastic leukemia (CCRF-SB) cell lines (4l: CC50 = 5.1 and 7.3 μ

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37

Kyr’iakulov, V., A. Makeev, T. Keda, and O. Zaporozhets. "SPECTORPHOTOMETRIC AND PROTOLYTIC PROPERTIES OF FUSED CYANOPIRIDINES." Bulletin of Taras Shevchenko National University of Kyiv. Chemistry, no. 1(55) (2018): 76–79. http://dx.doi.org/10.17721/1728-2209.2018.1(55).20.

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Development of new optical probes is a promising trend that has been actively implemented in recent years. A rational design of the probes should consider a number of parameters that contribute to the ability of the probe to exhibit highly selective optical response to the analyte. The obvious criteria are the chemical stability and reactivity of the probe, its photostability and the possibility of its reusable application. In this work, new probes based on fused benzothiazoles with different heterocyclic substituents were studied. The spectrophotometric characteristics of compounds in dimethy

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Saeed, Sohail, Moazzam Hussain Bhatti, and Peter G. Jones. "N-(Benzothiazol-2-yl)butyramide." Acta Crystallographica Section E Structure Reports Online 64, no. 8 (2008): o1486. http://dx.doi.org/10.1107/s1600536808020667.

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Tellitu, I., E. Domínguez, A. Correa, and R. SanMartin. "Synthesis of Benzothiazol-3-ones." Synfacts 2007, no. 1 (2007): 0021. http://dx.doi.org/10.1055/s-2006-955749.

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Zhang, Yong, Bi-lin Zhao, Shi-lei Zhang, Yuan Qu, and Xian-you Xia. "Bis(benzothiazol-2-ylmethyl)amine." Acta Crystallographica Section E Structure Reports Online 65, no. 7 (2009): o1674. http://dx.doi.org/10.1107/s1600536809023435.

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41

Mostafa, Mohamed Mokhtar M., Tamer S. Saleh, Salem M. Bawaked, Khadijah S. Alghamdi, and Katabathini Narasimharao. "Efficient and Eco-Friendly Perspectives for C-H Arylation of Benzothiazole Utilizing Pd Nanoparticle-Decorated Chitosan." Catalysts 12, no. 9 (2022): 1000. http://dx.doi.org/10.3390/catal12091000.

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In this contribution, an eco-friendly, sustainable, and efficient palladium nanoparticle-decorated chitosan (Pd@Chitosan) catalyst was synthesized by a simple impregnation method. The synthesized material was utilized as a heterogeneous catalyst for the C-H arylation of benzothiazole under ultrasonic irradiation. The Pd@Chitosan catalyst efficiently catalyzed the conversion of aryl iodides and bromides to 1-(4-(benzothiazol-2-yl)phenyl)ethan-1-one selectively. A single product of 83–93% yield was obtained in N,N-dimethylformamide solvent at 80 °C for 2.5h. This study reveals that Pd@Chitosan i

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42

Manna, Srimanta, Parthasarathi Karmakar, Syed Samim Ali, et al. "A Michael addition–cyclization-based switch-on fluorescent chemodosimeter for cysteine and its application in live cell imaging." New Journal of Chemistry 42, no. 7 (2018): 4951–58. http://dx.doi.org/10.1039/c8nj00465j.

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43

Zonjić, Iva, Lidija-Marija Tumir, Ivo Crnolatac, et al. "Recognition of ATT Triplex and DNA:RNA Hybrid Structures by Benzothiazole Ligands." Biomolecules 12, no. 3 (2022): 374. http://dx.doi.org/10.3390/biom12030374.

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Interactions of an array of nucleic acid structures with a small series of benzothiazole ligands (bis-benzothiazolyl-pyridines—group 1, 2-thienyl/2-benzothienyl-substituted 6-(2-imidazolinyl)benzothiazoles—group 2, and three 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazoles—group 3) were screened by competition dialysis. Due to the involvement of DNA:RNA hybrids and triplex helices in many essential functions in cells, this study’s main aim is to detect benzothiazole-based moieties with selective binding or spectroscopic response to these nucleic structures compared to regular (no

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44

Huang, Zhi-Qiang, Zhi-Qiang Du, Guan-Sheng Du, and Jun Yan. "3-(1,3-Benzothiazol-2-yl)-2-naphthol." Acta Crystallographica Section E Structure Reports Online 62, no. 5 (2006): o2010—o2011. http://dx.doi.org/10.1107/s1600536806013730.

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The molecule of the title compound, C17H11NOS, is planar, the dihedral angle between the benzothiazole and 2-naphthol systems being 3.44 (6)°. The face-to-face separation of 3.48 (2) Å indicates π–π stacking between parallel benzothiazole systems.

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R. Harish Kumar, D., and M. D. Karvekar. "Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity." E-Journal of Chemistry 7, no. 2 (2010): 636–40. http://dx.doi.org/10.1155/2010/817480.

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2-Acetyl benzofuran (1) was synthesized by refluxing salicylaldehyde and dry chloroacetone in presence of potassium carbonate. The product formed was reacted with 2-aminobenzothiazole with catalystp-toluene sulphonic acid to formN-[(1Z)-1-(benzofuran-2-yl)ethylidene]1,3-benzothiazol-2-amine (2). In cold condition, Staudinger reaction was carried out for compound (2) with various acid chlorides in presence of triethylamine to synthesize 4-[1-benzofuran-2-yl]-1-[1, 3-benzothiazol-2-yl]-4-methylazetidin-2-one (3a-3j). All the synthesized compounds were characterized on the basis of analytical dat

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46

Yadav, Ranjeet Kumar, Rajnish Kumar, Himanshu Singh, et al. "Synthesis, in vitro, in silico, and molecular docking studies of some new benzothiazole-linked pyrazoline derivatives as orally administered beta-ketoacyl-ACP synthase III and malonyl-CoA inhibitors." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 03 (2024): 289. http://dx.doi.org/10.59467/ijhc.2024.34.289.

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A new series of 2-[4-(1,3-benzothiazole-2-yl)phenoxy]-1(3-substituted-[5-substituted])-1H-pyrazole-1-yl) ethan-1-ones (9a-l) was synthesized by reacting 2-[4-(1,3-benzothiazol-2-yl)phenoxy]acetohydrazide (8) with different chalcones (3a-l). The antibacterial potential of the synthesized compounds was determined by established methods including determination of MIC and zone of inhibition. Although all the synthesized derivatives were found to possess good antibacterial activity against Gram (-ve) and Gram (+ve) bacterial strains, compounds 9e, 9i, 9j, and 9k were found to be better than the oth

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47

V. Gadhave, Ranjit, Sachin S. Khade, Yogita S. Ozarde, Somdatta Y. Chaudhari, Arti G. Swami, and Mukesh K. Meena. "DESIGN, SYNTHESIS AND EVALUATION OF N-(BENZO[D]THIAZOL-2-YL)-2-OXO2H-CHROMENE-3-CARBOXAMIDE DERIVATIVES AS POTENTIAL ANTIOXIDANT AND ANTIBACTERIAL AGENTS." Indian Drugs 59, no. 10 (2022): 20–29. http://dx.doi.org/10.53879/id.59.10.13222.

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This research is focused on designing, synthesis and biological evaluation of a series of coumarin based benzothiazole derivatives. The ligands were identified by docking study for antioxidant and antibacterial potential using target proteins PDB:4H1J and PDB:3G75, respectively. The target molecules were synthesized as a series of substituted N-(benzothiazol-2-yl)-2-oxo-chromene-3-carboxamides (7a–h) by condensation of substituted benzo[d]thiazol-2-amines with in situ synthesized substituted 2-oxo-2H-chromene-3-carbonyl chlorides. Infrared spectroscopy and 1 H- nuclear magnetic resonance spect

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Khawar Rauf, M., Michael Bolte, and Amin Badshah. "N-(Benzothiazol-2-yl)-3-chlorobenzamide." Acta Crystallographica Section E Structure Reports Online 65, no. 6 (2009): o1245. http://dx.doi.org/10.1107/s1600536809016481.

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The title molecule, C14H9ClN2OS, exists in the solid state in its amide form with a typical C=O bond length, as well as shortened C—N bonds. The plane containing the HNCO atoms subtends dihedral angles of 12.3 (4) and 8.1 (3)° with the planes of the phenyl ring and benzothiazole group, respectively, whereas the dihedral angle between the planes of the phenyl ring and the benzothiazole group is 5.96 (6)°. In the crystal, molecules form intermolecular N—H...N hydrogen bonds, generating independent scissor-likeR22(8) dimers.

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Chu, Taiwei, Zejun Li, Xinqi Liu, and Xiangyun Wang. "In Vivo Evaluation of the Nitroimidazole-Based Thioflavin-T Derivatives as Cerebral Ischemia Markers." International Journal of Biomedical Imaging 2007 (2007): 1–5. http://dx.doi.org/10.1155/2007/49791.

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Timely imaging and accurate interpretation of cerebral ischemia are required to identify patients who might benefit from more aggressive therapy, and nuclear medicine offers a noninvasive method for demonstrating cerebral ischemia. Three nitroimidazole-based thioflavin-T derivatives,N-[4-(benzothiazol-2-yl)phenyl]-3-(4-nitroimidazole-1-yl) propanamide (4NPBTA),N-[4-(benzothiazol-2-yl)phenyl]-3-(4-nitroimidazole-1-yl)-N-methylpropanamide (4NPBTA-1), andN-[4-(benzothiazol-2-yl)phenyl]-3-(2-nitroimidazole-1-yl) propanamide (2NPBTA), were radioiodinated and evaluated as possible cerebral ischemia

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ANITHA, P., G. SRIDEVI, and K. K. REDDY. "ChemInform Abstract: Synthesis of 1-Benzothiazol-2-yl-2-arylimino-s-triazolo(5,1-b) benzothiazoles." ChemInform 27, no. 21 (2010): no. http://dx.doi.org/10.1002/chin.199621145.

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