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Journal articles on the topic 'Benzothiazole and Antibacterial and Antifungal activities'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Morsy, Mohamed A., Enas M. Ali, Mahmoud Kandeel, et al. "Screening and Molecular Docking of Novel Benzothiazole Derivatives as Potential Antimicrobial Agents." Antibiotics 9, no. 5 (2020): 221. http://dx.doi.org/10.3390/antibiotics9050221.

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The burden of antibiotic resistance necessitates a continued search for new antimicrobials. We evaluated the antimicrobial activities of novel benzothiazoles synthesized by our group. Antibacterial activity was evaluated in vitro in Staphylococcus aureus, Bacillus subtilis, and Escherichia coli, while the antifungal activity was tested in Candida albicans and Aspergillus niger, and expressed as the minimum inhibitory concentration (MIC; µg/mL). MIC values of benzothiazole compounds ranged from 25 to 200 µg/mL. Compounds 3 and 4 gave high antibacterial and moderate antifungal activities, while

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2

Purvesh, J. Shah. "Preparation, Characterization and Biological Screening of Novel Imidazoles." Journal of Progressive Research in Chemistry 2, no. 1 (2015): 54–60. https://doi.org/10.5281/zenodo.3970044.

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The 4-benzylidene-2-(4-methoxyphenyl)oxazol-5(4H)-one (B) has been prepared from cyclo condensation reaction between hippuric acid (A) with p-anisaldehyde. A series of 4-benzylidene-1-(substitued-2- benzothiazolyl)-2-(4-methoxyphenyl)-1H-imidazol-5(4H)-one (D1-6) have been synthesized from 2-amino substituted benzothiazole (C1-6) by condensation reaction with 4-benzylidene-2-(4-methoxyphenyl) oxazol-5(4H)-one (B). The synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR and Mass spectral data. All the compounds were screened for their antibacterial and antifungal activities.

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3

Tejasri, Alla* Rohini Kontham K. Swarna Madhuri Vasudha Bakshi. "SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 2-CYCLIC AMINE BENZOTHIAZOLE DERIVATIVES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2635–43. https://doi.org/10.5281/zenodo.1220232.

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The synthesis of a new series of 2-(cyclic amine)-1, 3-benzothiazole derivatives were synthesized in satisfactory yield and evaluated for their anti-microbial activities. 2-(cyclic amine)-1, 3-benzothiazoles were synthesized by treating 2-chloro benzothiazole with various cyclic amines. Purity of all the compounds has been checked on thin layer chromatographic plate technique. The structures of these newly synthesized compounds were characterized by elemental analysis and spectral data like IR, 1HNMR, 13CNMR and mass spectroscopy. All the synthesized compounds have been screened for their anti

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4

Duong Quoc, Hoan, Du Nguyen Duc, Luong Truong Minh, Thao Nguyen Thi Thach, and Hien Nguyen Thi Thu. "SYNTHESIS OF SOME BENZOTHIAZOLE ANILINE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITIES." Journal of Science Natural Science 67, no. 3 (2022): 68–74. http://dx.doi.org/10.18173/2354-1059.2022-0042.

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Three benzothiazole aniline derivatives 2a, 2b, and 2c were synthesized successfully by the reduction reaction of the respective nitro compound in neutral condition with Na2S2O4 in moderate yield. Structures of these derivatives were elucidated by IR, NMR, and MS analysis that referred to a strong agreement between spectral data and structures. Three compounds 2a, 2b, and 2c showed weak antioxidant, antibacterial and antifungal activities.

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5

Vaishnavi P. Bansod, Vinayak A. Katekar, and Swati Deshmukh. "A review: Synthesis characterization and in vitro anti-mycobacterial activity of some novel benzothiazole." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 169–79. http://dx.doi.org/10.30574/gscbps.2023.25.2.0433.

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Heterocyclic compounds, analogs, and derivatives have received a lot of interest recently because of their advantageous biological and pharmacological properties. Flexible substrates include the heterocyclic compounds that benzothiazole and its analogs can be used to synthesize. The benzothiazole nucleus is utilized to create a wide variety of pharmaceuticals. The biological activity of benzothiazole derivatives has recently undergone some intriguing alterations. These compounds stand out in the world of medicinal chemistry due to their high pharmacological potential. According to the World He

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6

Vaishnavi, P. Bansod, A. Katekar Vinayak, and Deshmukh Swati. "A review: Synthesis characterization and in vitro anti-mycobacterial activity of some novel benzothiazole." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 169–79. https://doi.org/10.5281/zenodo.10609199.

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Heterocyclic compounds, analogs, and derivatives have received a lot of interest recently because of their advantageous biological and pharmacological properties. Flexible substrates include the heterocyclic compounds that benzothiazole and its analogs can be used to synthesize. The benzothiazole nucleus is utilized to create a wide variety of pharmaceuticals. The biological activity of benzothiazole derivatives has recently undergone some intriguing alterations. These compounds stand out in the world of medicinal chemistry due to their high pharmacological potential. According to the World He

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7

Heda, Kavita. M. "Newly synthesized compounds from 2- hydrazino benzothiazole: Characterization, and evaluation of their antibacterial potential." International Journal of Advance and Applied Research 5, no. 23 (2024): 291–94. https://doi.org/10.5281/zenodo.13622529.

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Abstract:Serial of 1-tetra-O-benzoyl-β-D-glucosyl-3-(2)-hydrazino-1, 3-substituted benzothiozolyl thiocarbamide has been synthesized by the interaction  of   two pharmocophores,  tetra-O-benzoyl-β-D-glucosyl isothiocyanates and amine substituted 2-hydrazino-1,3-benzothiazoles in acetone medium. The reaction mixture was kept at room temp for 24 hrs. In acetone medium. Acetone is evaporated then product is recrystallised by petroleum ether (60-80%).  Benz-fused compounds have been employed in the synthesis of various compounds which show very potential pharmacologic

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8

Journal, Baghdad Science. "Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety." Baghdad Science Journal 10, no. 3 (2013): 658–72. http://dx.doi.org/10.21123/bsj.10.3.658-672.

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In this work, a series of new maleimides linked to substituted benzothiazole moiety were synthesized. Synthesis of these new cyclic imides were performed via three steps, the first one involved preparation of a series of 2-aminobenzothiazole substituted with different substituents via reaction of different primary aromatic amines with ammonium thiocyanate and bromine in glacial acetic acid. The prepared 2- amino benzothiozoles were introduced in the second step in reaction with maleic anhydride producing a series of N-(substituted benzothiazole-2-yl) maleamic acids.The resulted maleamic acids

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9

Azzawi, Ahlam Marouf AL, and Suroor Abdul Rhahman Mahdi. "Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety." Baghdad Science Journal 10, no. 3 (2013): 658–72. http://dx.doi.org/10.21123/bsj.2013.10.3.658-672.

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In this work, a series of new maleimides linked to substituted benzothiazole moiety were synthesized. Synthesis of these new cyclic imides were performed via three steps, the first one involved preparation of a series of 2-aminobenzothiazole substituted with different substituents via reaction of different primary aromatic amines with ammonium thiocyanate and bromine in glacial acetic acid. The prepared 2- amino benzothiozoles were introduced in the second step in reaction with maleic anhydride producing a series of N-(substituted benzothiazole-2-yl) maleamic acids.The resulted maleamic acids

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10

Zubenko, Alexander, Victor Kartsev, Anthi Petrou, et al. "Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents." Antibiotics 11, no. 11 (2022): 1654. http://dx.doi.org/10.3390/antibiotics11111654.

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In this manuscript, we describe the design, preparation, and studies of antimicrobial activity of a series of novel heteroarylated benzothiazoles. A molecular hybridization approach was used for the designing compounds. The in vitro evaluation exposed that these compounds showed moderate antibacterial activity. Compound 2j was found to be the most potent (MIC/MBC at 0.23–0.94 mg/mL and 0.47–1.88 mg/mL) On the other hand, compounds showed good antifungal activity (MIC/MFC at 0.06–0.47 and 0.11–0.94 mg/mL respectively) with 2d being the most active one. The docking studies revealed that inhibiti

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11

Mithlesh, Pawan K. Pareek, Hemraj Chippa, Ravikant, and Krishan G. Ojha. "Microwave synthesis of new biologically important 1,4-dihydropyridines containing benzothiazole moiety." Collection of Czechoslovak Chemical Communications 75, no. 3 (2010): 275–87. http://dx.doi.org/10.1135/cccc2009051.

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2,3,5,6-Tetrasubstituted-4-aryl-1-(6-ethoxybenzothiazol-2-yl)-1,4-dihydropyridines were synthesized by the reaction of 2-amino-6-ethoxybenzothiazole, an aromatic aldehyde and an active methylene compound in methanol by conventional or microwave irradiation method (solvent-free or with solid support). All compounds were tested for antibacterial and antifungal activities and the results were compared with standard drugs. Their acaricidal and antifeedant activities were also tested.

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12

Rajareddy, Aleti 1. *. Srinivasa Murthy Muppavarapu 2. "SYNTHESIS AND CHARACTERIZATION OF NOVEL BENZOTHIAZOLE DERIVATIVES CONTAINING INDOLE MOIETIES WITH ANTIMICROBIAL ACTIVITIES." Journal of Scientific Research in Pharmacy 7, no. 10 (2018): 118–23. https://doi.org/10.5281/zenodo.1473391.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he"(E)-5-chloro-1-((E)-1-((7-chloro-6-fluorobenzo[d]thiazol-2-yl)imino)ethyl)-3-(p-tolylimino)indolin-2-one" was to synthesize, purify, characterize and evaluate the biological activity of newly synthesized structural analogs of Benzothiazole derivatives Indole moieties. All these molecules (5a-5o) were characterized by FTIR, H<sup>1</sup>NMR and mass spectral analysis along with physical data. The biological potentials of the newly synthesized compounds are evaluated for their anti microbial activity</em><em> The stan

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13

Barbarossa, Alexia, Jessica Ceramella, Alessia Carocci, et al. "Benzothiazole-Phthalimide Hybrids as Anti-Breast Cancer and Antimicrobial Agents." Antibiotics 12, no. 12 (2023): 1651. http://dx.doi.org/10.3390/antibiotics12121651.

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The benzothiazole nucleus is a major heterocyclic scaffold whose therapeutic potential has been thoroughly explored due to its structural simplicity and ease of synthesis. In fact, several benzothiazole derivatives have been synthesized over time, demonstrating numerous pharmacological properties such as anticancer, antimicrobial, anti-inflammatory, and antioxidant activities. Herein, we propose a new series of benzothiazole-phthalimide hybrids obtained by linking the phthalimide moiety to differently substituted benzothiazole nuclei through the N atom. These compounds have been screened for t

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14

Panda, S., та S. K. Dash. "A Comparative Study of the Inclusion Complexes of 2-[5'-benzylidene-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole and 2-[5'-(p-N,N-dimethylamino- benzylidene)-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole withβ-Cyclodextrin". E-Journal of Chemistry 8, № 3 (2011): 1030–37. http://dx.doi.org/10.1155/2011/265484.

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The compounds 2-[5'-benzylidene-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole and 2-[5'-(p-N,N-dimethylamino- benzylidene)-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole have been synthesized in their purest forms starting from 2-aminobenzothiazole. The inclusion complexes of the above compounds have been prepared with β-cyclodextrin to increase their solubility and bioaccessibility in polar medium. The formation of inclusion complexes have been ascertained by study of spectral characteristic before and after inclusion complex formation. The stability of inclusion complexe

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15

Lungu, Lidia, Caleria Cucicova, Svetlana Blaja, et al. "Synthesis of Homodrimane Sesquiterpenoids Bearing 1,3-Benzothiazole Unit and Their Antimicrobial Activity Evaluation." Molecules 27, no. 16 (2022): 5082. http://dx.doi.org/10.3390/molecules27165082.

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Based on some homodrimane carboxylic acids and their acyl chlorides, a series of fourteen 2-homodrimenyl-1,3-benzothiazoles, N-homodrimenoyl-2-amino-1,3-benzothiazoles, 4′-methyl-homodrimenoyl anilides and 4′-methyl-homodrimenthioyl anilides were synthesized and their biological activities were evaluated on five species of fungi (Aspergillus niger, Fusarium solani, Penicillium chrysogenum, P. frequentans, and Alternaria alternata) and two strains of bacteria (Bacillus sp. and Pseudomonas aeruginosa). The synthesis involved the decarboxylative cyclization, condensation and thionation of the sai

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16

Ayman, B. Farag, and M. Michael Adel. "Spectrophotometric study of the interaction between a novel benzothiazolethioglycoside as antimicrobial agent with bovine serum albumin." Chemistry Research Journal 2, no. 2 (2017): 66–72. https://doi.org/10.5281/zenodo.13956269.

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This study is concerned with the interaction of a newly synthesized antimicrobial agent (BTT) with bovine serum albumin (BSA). BTT is a novel benzothiazolethioglycosides that was prepared via reaction of the benzothiazole and 2-thioxoimidazolidin-4-one thiolate salts with tri- acetylated cyclic xylopyranosyl bromide. It was tested for antimicrobial activity against different bacteria and fungi and it exhibited interesting high antibacterial activities against Gram +ve bacteria while it showed no antibacterial activities against Gram -ve bacteria nor antifungal activity. Spectrophotometry was t

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17

Rao, B. Ramalingeswara, Mohana R. Katiki, Kommula Dileep, et al. "Synthesis and Biological Evaluation of Benzothiazole-piperazinesulfonamide Conjugates and Their Antibacterial and Antiacetylcholinesterase Activity." Letters in Organic Chemistry 16, no. 9 (2019): 723–34. http://dx.doi.org/10.2174/1570178615666181113094539.

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Two series of N-2-benzothiazolyl-4-(arylsulfonyl)-1-piperazineacetamides/propanamides were synthesized from substituted 2-aminobenzothiazoles and were assayed for their in vitro antimicrobial activities against a panel of different pathogenic bacterial strains such as Micrococcus luteus, S. aureus, S. aureus MLS-16, B. subtilis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella planticola and Candida albicans. Among the synthesized compounds 5e,f,g and 6g,h,i showed promising antifungal activity against C. albicans as compared to the reference drug, miconazole. Further, compounds 6g,h,i sho

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18

Journal, Baghdad Science. "Synthesis , characterization and biological activity study of N-substituted sulfonamido maleimides substituted with different heterocycles." Baghdad Science Journal 7, no. 1 (2010): 641–53. http://dx.doi.org/10.21123/bsj.7.1.641-653.

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Eighteen new cyclic imides (maleimides) conncted to benzothiazole moiety through sulfonamide group were synthesized via multistep synthesis.The first step involved preparation of two maleamic acids N-phenylmaleamic acid and N-benzylmaleamic acid via reaction of maleic anhydride with aniline or benzyl amine.Dehydration of the prepared amic acids by treatment with acetic anhydride and anhydrous sodium acetate in the second step afforded N-phenylmaleimide and N- benzyl maleimide which in turn were treated with chlorosulfonic acid in the third step to afford 4-(N-maleimidyl) phenyl sulfonyl chlori

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19

Haroun, Michelyne, Christophe Tratrat, Katerina Kositzi, et al. "New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation." Current Topics in Medicinal Chemistry 18, no. 1 (2018): 75–87. http://dx.doi.org/10.2174/1568026618666180206101814.

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Background: Thiazole and benzothiazole derivatives, as well as thiazolidinones are very important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide spectrum of biological activities including antimicrobial activity. Objective: The goal of this paper is the designing of new benzothiazole based thiazolidinones and the evaluation of their biological activities. Methods: The designed compounds were synthesized using classical organic synthesis methods. The antimicrobial activity was evaluated using the method of microdilution. Results: The twelve newly synthesized

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Rawat, Bhupender Singh, and S. C. Mehra. "SYNTHESIS OF SOME NEW 1, 3-DI METHYL SUBSTITUTED GUANIDINE WITH POSSIBLE ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY." Green Chemistry & Technology Letters 2, no. 3 (2016): 138–40. http://dx.doi.org/10.18510/gctl.2016.233.

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The compounds containing thiazole, thiadiazole, oxazole, oxadiazole, imidazole, pyrimidine, pyridine & benzothiazole rings have been found to exhibit broad spectrum of biological activities.Derivatives of 1, 2, 4-thiadiazole and 1, 2, 4-thiadiazolidines exhibit antibacterial and antifungal activity1. Thiazolyl guanidines2 and various substituted aryl guanidine’s have been found to exhibit antibacterial & antifungal activities3.Keeping all these views in mind attempts were made to synthesized some new 1,3-di methyl Substituted Guanidine.In the present work 2,4 Dimethyl -3,5-(di Aryl imi

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21

Baldaniya, B. B. "Synthesis, Characterization and Biological Activity of 5-Arylidene-3-(6,7-dicloro-1,3-benzothiazol-2-yl)-phenyl-3,5-dihydro-4H-imidazol-4-ones." E-Journal of Chemistry 7, no. 1 (2010): 81–84. http://dx.doi.org/10.1155/2010/264036.

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Some novel 5-arylidene-3-(6,7-dichloro-1,3-benzothiazol-2-yl)-2-phenyl-3,5-dihydro-4H-imidazol-4-ones (6a-q)have been synthesized and characterized by elemental analyses, IR, NMR, and mass spectra. The products have been evaluated for antibacterial and antifungal activities against different strains of bacteria and fungi.

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Sharma, Diksha, Archana Sharma, Rakesh Pahwa, Avtar Chand Rana, and Prabodh Chander Sharma. "Design, synthesis, anti-infective and anti-cancer potential of thiazole based Pyrazoles bearing benzothiazole moiety." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4622–28. http://dx.doi.org/10.55522/jmpas.v11i2.2470.

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A new series of (E)-6-methyl-N-((3-phenyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-4-yl)methylene)benzo[d]thiazol-2-amine derivatives was developed. Structural investigation of the synthesized derivatives was carried out by several instrumental method of analysis like IR, and 1H-NMR spectroscopy. The titled analogues were examined for in-vitro anticancer and antiinfective activities. The biological findings specified that analogues 5a, 5b, 5d, 5e, 5f and 5g showed most potent antibacterial activity (MIC 62.5-250μg/mL) and 5a, 5e, 5f and 5g displayed most potent antifungal action (MIC 62.5-500 μg/mL

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23

Baldaniya, B. B. "Synthesis and Characterizations ofN2(Aryl)-N4,N6-bis (6, 7-dichloro-1, 3-benzothiazol-2-yl)-1, 3, 5-triazine-2, 4, 6-triamines as Biological Potent Agents." E-Journal of Chemistry 7, no. 1 (2010): 210–14. http://dx.doi.org/10.1155/2010/612853.

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Some novelN2-(Aryl)-N4,N6-bis (6, 7-dichloro-1, 3-benzothiazol-2-yl)-1, 3, 5-triazine-2, 4, 6-triamines (4a-u) have been synthesized and characterized by elemental analyses, IR, NMR, and mass spectra. The products have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria and also on different strains of fungi. Introduction of –OH, -OCH3, -NO2, -Cl and –Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.

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Pisal, Pooja, Meenakshi Deodhar, Amol Kale, Ganesh Nigade, and Smita Pawar. "DESIGN, SYNTHESIS, DOCKING STUDIES AND BIOLOGICAL EVALUATION OF 2-PHENYL-3-(SUBSTITUTED BENZO[d] THIAZOL-2-YLAMINO)-QUINAZOLINE-4(3H)-ONE DERIVATIVES AS ANTIMICROBIAL AGENTS." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 10 (2018): 57. http://dx.doi.org/10.22159/ijpps.2018v10i10.28480.

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Objective: A new series 2-phenyl-3-(substituted benzo[d] thiazol-2-ylamino)-quinazoline-4(3H)-one was prepared by the fusion method by reacting 2-phenyl benzoxazine with 2-hydrazino benzothiazole and it was evaluated for their antimicrobial activity against gram positive, gram negative bacteria and fungi.Methods: Titled compounds were synthesized by fusion reactions. These compounds were evaluated by in vitro antibacterial and antifungal activity using the minimum inhibitory concentration and zone of inhibition methods. The synthesized compounds were characterized with the help of infrared, NM

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Chandni, Jain, Gopal Ram, Panwar Lalita, and Nagar Meena. "Phosphorylation and thiophosphorylation of 2-(4'-aminophenyl)-6-methyl benzothiazole and their biological activities." Journal of Indian Chemical Society 93, June 2016 (2016): 571–75. https://doi.org/10.5281/zenodo.5638395.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>E-mail</em> : nagar_meena@yahoo.com <em>Manuscript received online 15 December 2015, accepted 30 January 2016</em> Some novel organophosphorus compounds of the type [(C<sub>14</sub>H<sub>11</sub>N<sub>2</sub> S)<sub>n</sub>P(O)Cl<sub>3-n</sub>]/[(C<sub>14</sub>H<sub>11</sub>N<sub>2</sub> S)<sub>n</sub>P(S)Cl<sub>3-n</sub>] {where n=1–3} have been easily synthesized by the reaction of 2-(4'-aminophenyl)-6-methyl benzothiazole (C<sub>14</sub>H<sub>11</sub>N<sub>2</sub> S) with phosphorus oxychloride

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Tejashree, Deokule. "1,3,4-Thiadiazole and its Derivatives: A Versatile Moiety." Medicinal Chemistry 13, no. 1 (2023): 9. https://doi.org/10.37421/2161-0444.2023.13.660.

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The evaluation of thiazole's biological activity, such as antibacterial, antiprotozoal, antitubercular, antifungal and anthelmintic, with an emphasis on their potential medicinal applications, is desirable because the thiazole has an important component effect on the pharmacophores of a large number of medicinally significant molecules. We are particularly interested in investigating newly synthesized aminothiazoles, particularly 2-aminothiazole derivatives, a class of heterocyclic ring systems with antiviral, antimicrobial, anticancer and anti-inflammatory properties, respectively. Numerous h

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J Khairnar, Bhikan, Rahul S. Salunke, Premchand B. Patil, et al. "Synthesis and Antimicrobial Activity of Some New 1, 4-Benzothiazine Containing Thiosemicarbazides and 1, 3, 4-Oxadiazole Derivatives." E-Journal of Chemistry 9, no. 1 (2012): 318–22. http://dx.doi.org/10.1155/2012/902784.

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A series of novel 3- methyl-7-substituted-4H,4-benzothiazine-2-carbohydrazide (3a-e) and corresponding thiosemicarbazides (4-a-q); 2-[3-methyl-7-substituted- 4H-1, 4-benzothiazine-2-yl]-N-(aryl) hydrazine carbothiamide have been synthesized. The thiosemicarbazide when cyclized with iodine via intramolecular cyclisation gave benzothiazonyl oxadiazoles (5-a-q); 5-(3-methyl -7-substitued-4H- 1,4-benzothiazin-2-yl)-N—aryl- 1,3,4- oxadiazol -2-amine and the compounds were tested for antibacterial and antifungal activities against different microorganisms.

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R., S. Varma. "Aminomethylation reactions of nitrogen and sulfur five membered heterocyclic compounds." Journal of India Chemical Society Vol 81, Aug 2004 (2004): 627–38. https://doi.org/10.5281/zenodo.5829941.

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Department of Chemistry, University of Lucknow, Lucknow-226 007, India <em>E-mail : </em>profraj @sancharnet.in Five membered nitrogen and sulfur heterocyclic compounds such as isatins, benzimidazole, benzimidazolin-2-thione, benzoxazoli none- 2, benzoxazoline-2-thione, benzotriazole, benzothiazoline-2 -thione, 1 ,3,4-oxadiazoline-5-thione and 1,2,4-triazolin-5-thiones have been prepared and subjected to aminomethylation reactions in presence of formaldehyde and amines. Secondary as well as primary aromatic amines bearing different substituents have been successfully utilized in the aminomethy

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Nishad, Ravi K., Karuna S. Shukla, and Pooja A. Chawla. "Design and Synthesis of 2-Substituted Benzothiazole Derivatives as Antioxidant and Antimicrobial Agents." Current Bioactive Compounds 16, no. 8 (2020): 1242–48. http://dx.doi.org/10.2174/1573407216666200128160438.

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Background: An upsurge in the number of antibiotic-resistant microbial infections has warranted the discovery and development of new antibiotics. This is a matter of great concern for effective therapy for a search of novel antimicrobial agents. Literature has a number of reports of involvement of oxidative stress due to an imbalance between the generation and neutralization of free radicals in many diseases. Heterocyclic compounds have been involved in the treatment of various disorders. Benzothiazole is one such heterocyclic nucleus having benzene ring merged with the thiazole ring. Among th

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Senthilkumar, Gopal, Chinnusamy Umarani, and Dhurairaj Satheesh. "Synthesis, Spectral Characterization, Antibacterial, Antifungal and Anticancer Evaluation of N-[4-(1,3-Benzothiazol-2-ylcarbamoyl)phenyl]pyrazine-2-carboxamide." Asian Journal of Organic & Medicinal Chemistry 6, no. 2 (2021): 102–6. http://dx.doi.org/10.14233/ajomc.2021.ajomc-p320.

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A new organic compound, N-[4-(1,3-benzothiazol-2-ylcarbamoyl)-phenyl]pyrazine-2-carboxamide was synthesized through the reaction between 4-amino-N-(benzo[d]thiazol-2-yl)benzamide and pyrazine-2-carboxylic acid. The synthesized compound has been characterized by spectroscopic techniques such as 1H NMR, 13C NMR, FT-IR and mass spectroscopy. The synthesized compound was screened to antibacterial (Staphylococcus aureus, Klebsiella pneumonia and Escherichia coli), antifungal (Candida albicans and Aspergillus niger) activities. The anticancer activity of the title compound was also evaluated against

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Padmini, T. R., H. M. Vagdevi, and Usha Jinendra. "Synthesis of Benzoxazole Associated Benzothiazine-4-ones and their in vitro and in silico Antimicrobial, Antioxidant Activities." Asian Journal of Chemistry 33, no. 1 (2020): 137–50. http://dx.doi.org/10.14233/ajchem.2021.22964.

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In present study, a series of 3-[(5-methyl-1,3-benzoxazol-2-yl)amino]-2-phenyl-2,3-dihydro-4H-1,3- benzothiazin-4-ones (6a-n) were synthesized and elucidated by elemental, FT-IR, 1H & 13C NMR and LC-MS studies. The in vitro antibacterial screening against Gram-positive bacterial strains such as B. subtilis, S. aureus, S. epidermidis and Gram-negative bacteria such as E. coli, P. aeruginosa was carried in comparison with tetracycline as reference standard. Antifungal activities against different fungal strains namely R. oryzae, A. niger, A. favus, C. albicans and S. cerevisiae have been eva

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32

Evren, Asaf Evrim, Sinem Tekinkoca, and Leyla Yurttas. "Synthesis and Antimicrobial Activity of Some New N-(1H-benzimidazol-2- yl)-2-mercaptoacetamide Derivatives." Letters in Drug Design & Discovery 15, no. 2 (2018): 154–59. http://dx.doi.org/10.2174/1570180814666170619092147.

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Background: Due to multi-drug, extended-drug, and pandrug resistance phenotypes, bacterial resistance to antibiotics and fungal infections are a general health issue. Particulary, increase of fungal infections due to secondary cause of human diseases have been observed. An extensive variety of benzimidazole derivatives have been characterized for their chemotherapeutic significance. Benzimidazole derivatives have received important attention because of pharmacological significance during current years, especially antimicrobial, anti-fungal, antitubercular, antioxidant, anti-Alzheimer's disease

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33

Pareek, Pawan, Ravi Kant, Sanjeev Shukla, and Krishan Ojha. "Rapid synthesis and biological evaluation of 1,4-dihydropyridine derivatives containing a benzothiazolyl moiety." Open Chemistry 8, no. 1 (2010): 163–73. http://dx.doi.org/10.2478/s11532-009-0114-z.

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AbstractA series of N-(6-methylbenzothiazolyl)-2,3,5,6-tetrasubstituted-4-(aryl)-1,4-dihydropyridines were synthesized by reaction of 2-amino-6-methylbenzothiazole, aromatic aldehyde and active methylene compound in methanol by conventional, as well as, microwave irradiation (solvent free and solid support) methods. The microwave irradiation technique gives better yield and shorter reaction time. Among solid supported microwave irradiation better yields are obtained in acidic alumina as compared to silica, neutral alumina, and basic alumina. All compounds were tested for antibacterial and anti

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34

Ion, Emilia, Mirela Calinescu, Ana Emandi, Victoria Badea, and Dumitru Negoiu. "Copper(II) Complex Compounds with Mixed Hydrazone Ligands." Revista de Chimie 59, no. 1 (2008): 12–16. http://dx.doi.org/10.37358/rc.08.1.1697.

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Three Cu(II) complex compounds with mixed hydrazone ligands have been prepared and characterized in view of their potential biological activity. The complex compounds have the formulas: [Cu(HLa)(Lc)Br], [CuLaLc] and [CuLbLc] . Na, where HLa = 4-dimethylamino benzaldehyde-2-benzothiazolyl hydrazone, H2Lb = 2-hydroxybenzaldehyde-2-benzothiazolyl hydrazone and HLc = 2-hydroxy-1-naphthyliden-N,N-dimethyl hydrazone. The complexes have been characterized by elemental and thermogravimetrical analysis, infrared, electronic and EPR spectra. EPR spectral studies of the complexes gave axial symmetry, wit

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35

Raveendiran, C., and P. Prabukanthan. "Synthesis, Crystal Growth, Crystal Arrangement, Optical, Thermal, NLO and Biological Investigations of Heterocyclic Compounds of N-(1,3-benzothiazol-2-yl)benzamide and N-(1,3-benzothiazol-2-yl)-2-fluorobenzamide." European Journal of Engineering and Technology Research 6, no. 5 (2021): 181–89. http://dx.doi.org/10.24018/ejers.2021.6.5.2554.

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Heterocyclic organic nonlinear optical materials of N-(1,3-benzothiazol-2-yl)benzamide [2-BTBA] and N-(1,3-benzothiazol-2-yl)-2-fluorobenzamide [2-BTFBA] were orchestrated by benzoylation of 2-aminobenzothiazole utilizing subbed benzoyl chloride. The orchestrated mixtures2-BTBA and 2-BTFBA molecular ion peaks at 253.9 & 272 were affirmed by GC-MS. The grown single crystals of 2-BTBA and 2-BTFBA were developed by slow evaporation method at room temperature with a combination of ethyl acetate & methanol as dissolvable. The X-ray diffraction investigations of equally 2-BTBA & 2-BTFBA

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36

Raveendiran, C., and P. Prabukanthan. "Synthesis, Crystal Growth, Crystal Arrangement, Optical, Thermal, NLO and Biological Investigations of Heterocyclic Compounds of N-(1,3-benzothiazol-2-yl)benzamide and N-(1,3-benzothiazol-2-yl)-2-fluorobenzamide." European Journal of Engineering and Technology Research 6, no. 5 (2021): 181–89. http://dx.doi.org/10.24018/ejeng.2021.6.5.2554.

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Heterocyclic organic nonlinear optical materials of N-(1,3-benzothiazol-2-yl)benzamide [2-BTBA] and N-(1,3-benzothiazol-2-yl)-2-fluorobenzamide [2-BTFBA] were orchestrated by benzoylation of 2-aminobenzothiazole utilizing subbed benzoyl chloride. The orchestrated mixtures2-BTBA and 2-BTFBA molecular ion peaks at 253.9 & 272 were affirmed by GC-MS. The grown single crystals of 2-BTBA and 2-BTFBA were developed by slow evaporation method at room temperature with a combination of ethyl acetate & methanol as dissolvable. The X-ray diffraction investigations of equally 2-BTBA & 2-BTFBA

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37

Pal, Narendra, and Anand Kumar Arya. "An efficient and facile synthesis of Zn(II) complexes with 2-substituted benzothiazoles and glycine- and alanine-based ligands having antifungal and antibacterial activities." Research on Chemical Intermediates 39, no. 2 (2012): 553–60. http://dx.doi.org/10.1007/s11164-012-0578-x.

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38

Obasi, N. L., Okoye C. O. Benedict, P. O. Ukoha, and A. O. Anaga. "Syntheses, Characterization, and Antimicrobial Screening of N-(benzothiazol-2-yl)benzenesulphonamide and its Cu(I), Ni(II), Mn(II), Co(II), and Zn(II) Complexes." E-Journal of Chemistry 9, no. 4 (2012): 2354–70. http://dx.doi.org/10.1155/2012/496541.

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N-(benzothiazol-2-yl)benzenesulphonamide (BS2ABT) was synthesized by the condensation (by refluxing) of 2-aminobenzothiazole and benzenesulphonylchloride in acetone at 140ºC. The resulting crude precipitates were recrystallized from dimethylformamide (DMF). Five metal complexes of copper(I), nickel(II), manganese(II), cobalt(II) and zinc(II) of the ligands were synthesized. The compounds were characterized using magnetic susceptibility measurements, UV/VIS spectrophotometry, infra red, proton and13C nmr spectroscopies. The antimicrobial tests of the ligands and its metal complexes were carried

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39

Dhurgham Qasim Shaheed, Jawad Alshams, Ihsan Alrubaie, Hayder Kadhim Abbas, and Ali Jabbar Radhi. "Synthesis and studying biological activity of new benzothiazole derivatives." Journal of Pharmaceutical Negative Results 13, no. 4 (2022): 573–78. http://dx.doi.org/10.47750/pnr.2022.13.04.075.

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A variety of novel tetrazole derivatives attached to the β-lactam ring was made utilizing heptanitrile in a reaction with generated azide-β-lactam derivatives, and these compounds were then studied using IR and NMR spectroscopy. Biological testing showed that most of the final compounds showed good antibacterial and antifungal activity, particularly derivative (b3), which shown antifungal and antibacterial efficacy that was on par with or even superior to that of the reference drugs Fluconazole and Amoxicillin.

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Maddila, Suresh, Sridevi Gorle, Nuthangi Seshadri, Palakondu Lavanya, and Sreekanth B. Jonnalagadda. "Synthesis, antibacterial and antifungal activity of novel benzothiazole pyrimidine derivatives." Arabian Journal of Chemistry 9, no. 5 (2016): 681–87. http://dx.doi.org/10.1016/j.arabjc.2013.04.003.

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41

Baraskar, Archana Ratnakar, Ratnamala P. Sonawane, Nilesh Kshirsagar, and Sultan Pathan. "Biological Activities of Schiff Bases Incorporating Benzothiazole Moiety." Asian Journal of Organic & Medicinal Chemistry 7, no. 3 (2022): 249–64. http://dx.doi.org/10.14233/ajomc.2022.ajomc-p392.

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The functionalization of organic molecules with the Schiff bases having benzothiazole moiety has grown rapidly due to its multiple therapeutic and pharmacological properties. They have driven enormous studies on their stereochemistry, bioactivity and synthetic attempts. The benzothiazole moiety is infinitesimal but broadly used for industrial purposes and also exhibits a broad range of biological activities. Study carried out on Schiff bases having benzothiazole had well-known promising activities like antimicrobial, antimalarial, antifungal, antitubercular, antiviral, antitumor, analgesic, an

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42

Pramod, Kumar Sahu, Kumar Sahu Praveen, and Dayal Agarwa Dau. "Design, synthesis and synergistic antioxidant, antibacterial, antifungal activity of nitrogen heterocycles." Journal of Indian Chemical Society Vol. 92, Feb 2015 (2015): 169–82. https://doi.org/10.5281/zenodo.5602614.

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School of Studies in Chemistry, Jiwaji University, Gwalior-474 011, Madhya Pradesh, India  Department of Industrial Chemistry, Jiwaji University, Gwalior-474 011, Madhya Pradesh, India <em>E-mail</em> : profdd.agarwal@gmail.com <em>Manuscript received 31 October 2014, accepted 31 December 2014</em> A convenient, facile and efficiently catalyzed synthesis of nitrogen heterocycles using aldehydes, 1,3-dicarbonyl and 3-amino-1,2,4-triazole/urea/thiourea/2-amino benzothiazole in the presence of L-proline at 65–70<sup>o</sup>C under solvent free conditions is being described. Results cle

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43

Gjorgjieva, Marina, Tihomir Tomašič, Danijel Kikelj, and Lucija Peterlin Mašič. "Benzothiazole-based Compounds in Antibacterial Drug Discovery." Current Medicinal Chemistry 25, no. 38 (2019): 5218–36. http://dx.doi.org/10.2174/0929867324666171009103327.

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Numerous compounds with a benzothiazole scaffold that have been described in the literature show promising activities against several Gram-positive and Gramnegative bacteria, and also against Mycobacterium tuberculosis. Benzothiazole-based antibacterial compounds bind to different biological targets in bacterial cells and have been shown to be inhibitors of enzymes that are important for essential processes in the bacterial cells, such as cell-wall synthesis, cell division, and DNA replication, or are important for different biosynthetic pathways of essential compounds in bacterial cells, such

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44

Luo, Bo, Ding Li, An-Ling Zhang, and Jin-Ming Gao. "Synthesis, Antifungal Activities and Molecular Docking Studies of Benzoxazole and Benzothiazole Derivatives." Molecules 23, no. 10 (2018): 2457. http://dx.doi.org/10.3390/molecules23102457.

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Based on benzoxazole and benzothiazole scaffold as an important pharmacophore, two series of 2-(aryloxymethyl) benzoxazole and benzothiazole derivatives were synthesized and their antifungal effects against eight phytopathogenic fungi were evaluated. Compounds 5a, 5b, 5h, and 5i exhibited significant antifungal activities against most of the pathogens tested. Especially 5a, 5b, 5h, 5i, 5j, and 6h inhibited the growth of F. solani with IC50 of 4.34–17.61 μg/mL, which were stronger than that of the positive control, hymexazol (IC50 of 38.92 μg/mL). 5h was the most potent inhibitor (IC50 of 4.34

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45

Hajam, Younis Ahmad, Neelam Bhatti, Rajesh Kumar, Shweta Singh, and Indu Kumari. "Comparative antibacterial and antifungal activities of Cinnamomum Tamala Nees & Eberm. and Taraxicum officinale leaf extract." International Journal of Pharmaceutical Chemistry and Analysis 10, no. 1 (2023): 39–43. http://dx.doi.org/10.18231/j.ijpca.2023.007.

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Present study proposed to analyse the antibacterial and antifungal activities of Nees & Eberm. And leaf extract against well-known pathogenic bacteria and andand Extract was prepared in 70% ethanol using soxhelt extraction unit. Paper disc diffusion method was used for antibacterial and antifungal activities of extract. The culture was maintained in nutrient agar medium during the whole experiment. Penicillin and tetracycline were used as standard antibiotics for comparative antibacterial assessment of extracts and sabaround’s browth medium was for assessment of antifungal activities of ex

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46

Sulistyowaty, Melanny Ika, Galih Satrio Putra, Tutuk Budiati, et al. "Synthesis, In Silico Study, Antibacterial and Antifungal Activities of N-phenylbenzamides." International Journal of Molecular Sciences 24, no. 3 (2023): 2745. http://dx.doi.org/10.3390/ijms24032745.

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Antibiotic and antifungal resistance problems have been prevalent in recent decades. One of the efforts to solve the problems is to develop new medicines with more potent antibacterial and antifungal activity. N-phenylbenzamides have the potential to be developed as antibacterial and antifungal medicine. This study aimed to synthesize N-phenylbenzamides and evaluate their in silico and in vitro antibacterial and antifungal activities. The in silico studies conducted absorption, distribution, metabolism, excretion and toxicity (ADMET) predictions along with molecular docking studies. ADMET pred

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47

Liu, Qing, Xiao Meng, Ya Li, Cai-Ning Zhao, Guo-Yi Tang, and Hua-Bin Li. "Antibacterial and Antifungal Activities of Spices." International Journal of Molecular Sciences 18, no. 6 (2017): 1283. http://dx.doi.org/10.3390/ijms18061283.

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48

Nagaki, Masahiko, Takashi Narita, Hiroaki Ichikawa, Jun Kawakami, and Akio Nakane. "Antibacterial and antifungal activities of isoprenoids." Transactions of the Materials Research Society of Japan 36, no. 1 (2011): 55–58. http://dx.doi.org/10.14723/tmrsj.36.55.

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49

Baldaniya, B. B., and P. K. Patel. "Synthesis, Antibacterial and Antifungal Activities ofsDerivatives." E-Journal of Chemistry 6, no. 3 (2009): 673–80. http://dx.doi.org/10.1155/2009/196309.

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SeveralNʹ-{4-[(3-chloro-4-fluorophenyl) amino]-6-[(-aryl) amino] -1, 3, 5-triazin-2-yl} isonicotinohydrazides (6a-r) andN2-(Aryl)-N4,N6-dipyrimidin-2-yl-1,3,5-triazine-2,4,6-triamines (4a-o) were prepared. All newly synthesized compounds have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria and also on different strains of fungi. Introduction of -OH, -OCH3, -NO2, -Cl and -Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.

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Ahmad, Bashir, S. M. Hassan Shah, Shumaila Bashir, Muhammad Nisar, and M. Iqbal Chaudry. "Antibacterial and antifungal activities ofandrachne cordifoliamuell." Journal of Enzyme Inhibition and Medicinal Chemistry 22, no. 6 (2007): 726–29. http://dx.doi.org/10.1080/14756360701305828.

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