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Journal articles on the topic 'Benzothiazole and thiazoles'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Bannimath, G., C. Sambireddy, M. N. Purohit, and G. V. Pujar. "Synthesis and Pharmacological Evaluation of 7-chloro-6-fluoro-2-(5-aminooxazol/thiazol-2-aryldenylamino)-benzo(1,3)thiazoles." Journal of Scientific Research 3, no. 1 (2010): 121. http://dx.doi.org/10.3329/jsr.v3i1.6166.

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New series of 7-chloro-6-fluoro-2-(5-aminooxazol/thiazol-2-aryldenylamino)-benzo (1,3)thiazoles (Schiff’s base)(5a-g, 6a-g) were synthesized from 7-chloro-6-fluoro-2-(5-amino-oxazol/thiazol-2-amino)-benzothiazole (4a-b). Structures of the compounds were verified by 1H-NMR spectra. The synthesized compounds were screened for in vivo analgesic and antiinflammatory activities. Some of the compounds showed moderate activities.Keywords: Benzothiazole; Schiff’s base; Analgesic activity; Antiinflammatory activity.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserve

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2

Huang, Tonghui, Xin Wu, Yongbo Yu, Lin An, and Xiaoxing Yin. "A convenient synthesis of 2-acyl benzothiazoles/thiazoles from benzothiazole/thiazole and N,N'-carbonyldiimidazole activated carboxylic acids." Tetrahedron Letters 60, no. 25 (2019): 1667–70. http://dx.doi.org/10.1016/j.tetlet.2019.05.043.

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3

Colorado-Peralta, Raúl, José Luis Olivares-Romero, Sharon Rosete-Luna, et al. "Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity." Inorganics 11, no. 5 (2023): 185. http://dx.doi.org/10.3390/inorganics11050185.

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Throughout human history, bacteria and fungi have caused infections that are difficult to combat. For this reason, countless research groups have developed novel compounds to solve this problem. Thiazole and benzothiazole are present in different structures with interesting biological effects and are used to develop new effective antimicrobial agents. Moreover, nitrogen atoms that are present in this heterocycle allow for coordination with various metals, forming metal complexes that enhance the biological activity of organic ligands that are often used as commercial drugs. This bibliographica

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4

Al-Soud, Yaseen A., Haitham H. Al-Sa’doni, Sadeekah O. W. Saber, Reem H. M. Al-Shaneek, Najim A. Al-Masoudi, and P. La Colla. "Synthesis, in vitro Antiproliferative and Anti-HIV Activity of New Derivatives of 2-Piperazino-1,3-benzo[d]thiazoles." Zeitschrift für Naturforschung B 65, no. 11 (2010): 1372–80. http://dx.doi.org/10.1515/znb-2010-1113.

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A series of N-{2-oxo-2-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]}-(het)arenecarboxamides 4a - l, sulfonamide derivatives 8a - i as well as benzothiazole-containing N1-(2-oxoethyl)-N1-arylthioureas 9a - c have been synthesized. Compounds 4a - l and 9a were evaluated, in vitro, for their antiproliferative activity against a large panel of human tumor-derived cell lines. Compounds 4l and 9a were the most potent analogs in this series, showing remarkable effects on human splenic B-lymphoblastoid cells (WIL-2NS) and human acute B-lymphoblastic leukemia (CCRF-SB) cell lines (4l: CC50 = 5.1 and 7.3 μ

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5

Bogert, Marston Taylor, and Frederick Grant Hess. "Researches on thiazoles: XV. Benzothiazole arsenicals of arsphenamine (salvarsan) type." Recueil des Travaux Chimiques des Pays-Bas 48, no. 9 (2010): 904–11. http://dx.doi.org/10.1002/recl.19290480910.

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6

Taha, K. K., Musa E. Mohamed, S. A. Khalil, and S. A. Talab. "Inhibition of Brass Corrosion in Acid Medium Using Thiazoles." International Letters of Chemistry, Physics and Astronomy 14 (September 2013): 87–102. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.14.87.

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Brass as an alloy composed mainly of copper is great industrial uses such as heat exchangers and similar other facility due to its good thermal properties. Due to the presence of the considerable ratio of zinc the alloy suffers from zinc dissolution or dezincification. Dezincification rate increases with the increase in the ratio of zinc in the alloy. In this study benzothiazole (BTH) and its substituent’s 2-methylbenzothiazole (MeBTH), 2-aminobenzothiazole (ABTH), 2-mercaptobenzothiazole (MBTH) and 2-phenylbenzothiazole (PhBTH) have been used as corrosion inhibitors for α-brass in stirred 0.1

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7

Taha, Kamal K., Musa E. Mohamed, S. A. Khalil, and S. A. Talab. "Inhibition of Brass Corrosion in Acid Medium Using Thiazoles." International Letters of Chemistry, Physics and Astronomy 14 (May 19, 2013): 87–102. http://dx.doi.org/10.56431/p-e6kqj6.

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Brass as an alloy composed mainly of copper is great industrial uses such as heat exchangers and similar other facility due to its good thermal properties. Due to the presence of the considerable ratio of zinc the alloy suffers from zinc dissolution or dezincification. Dezincification rate increases with the increase in the ratio of zinc in the alloy. In this study benzothiazole (BTH) and its substituent’s 2-methylbenzothiazole (MeBTH), 2-aminobenzothiazole (ABTH), 2-mercaptobenzothiazole (MBTH) and 2-phenylbenzothiazole (PhBTH) have been used as corrosion inhibitors for α-brass in stirred 0.1

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8

Rahate, Ankita S., Neha A. Shah, Prashant S. Jadhav, Sagar T. Sankpal, and Hemant V. Chavan. "Silicotungstic Acid Catalyzed Microwave Assisted Synthesis of Fused 4H-Pyrimido[2,1-b]thiazoles and 4H-Pyrimido[2,1-b]benzothiazoles under Solvent-Free Conditions." Asian Journal of Organic & Medicinal Chemistry 5, no. 1 (2020): 62–67. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p236.

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The silicotungstic acid catalyzed microwave assisted synthesis of substituted 4H-pyrimido[2,1- b]thiazole and 4H-pyrimido[2,1-b]benzothiazole derivatives was achieved by one-pot multi-component reaction of 2-aminothiazole or 2-aminobenzthiazole, aldehyde and ethyl acetoacetate under solventfree condition. A simple, rapid and environmental friendly protocol, good yields and easy work-up are some advantages of this protocol. The structures of the synthesized compounds were established by FT-IR, 1H NMR and mass spectral data.

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9

Satish, Kittur* Venkatesh Hanumanthachar Joshi. "A REVIEW ON FLURO-SUBSTITUED BENZOTHIOZOLES: A NEW PROFILE OF BIOLOGICAL ACTIVITIES." Indo American Journal of Pharmaceutical Sciences 05, no. 01 (2018): 130–34. https://doi.org/10.5281/zenodo.1136528.

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Benzothiazoles are an important class of bioactive & industrially important organic compounds recently; heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. Heterocyclic compounds analogues and their derivatives have attracted strong interest due to their biological and Pharmacological properties. Benzothiazoles are bicyclic ring system. A number of 2‐Aminobenzothiazoles have been studied as central muscle relaxants and found to interfere with glutamate neurotransmission in bioch

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10

Hwang, YeJi, Jieun Lee, Hee Jin Jung, et al. "A Novel Class of Potent Anti-Tyrosinase Compounds with Antioxidant Activity, 2-(Substituted phenyl)-5-(trifluoromethyl)benzo[d]thiazoles: In Vitro and In Silico Insights." Antioxidants 11, no. 7 (2022): 1375. http://dx.doi.org/10.3390/antiox11071375.

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Sixteen compounds bearing a benzothiazole moiety were synthesized as potential tyrosinase inhibitors and evaluated for mushroom tyrosinase inhibitory activity. The compound 4-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)benzene-1,3-diol (compound 1b) exhibited the highest tyrosinase activity inhibition, with an IC50 value of 0.2 ± 0.01 μM (a potency 55-fold greater than kojic acid). In silico results using mushroom tyrosinase and human tyrosinase showed that the 2,4-hydroxyl substituents on the phenyl ring of 1b played an important role in the inhibition of both tyrosinases. Kinetic studies on mus

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11

Tejashree, Deokule. "1,3,4-Thiadiazole and its Derivatives: A Versatile Moiety." Medicinal Chemistry 13, no. 1 (2023): 9. https://doi.org/10.37421/2161-0444.2023.13.660.

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The evaluation of thiazole's biological activity, such as antibacterial, antiprotozoal, antitubercular, antifungal and anthelmintic, with an emphasis on their potential medicinal applications, is desirable because the thiazole has an important component effect on the pharmacophores of a large number of medicinally significant molecules. We are particularly interested in investigating newly synthesized aminothiazoles, particularly 2-aminothiazole derivatives, a class of heterocyclic ring systems with antiviral, antimicrobial, anticancer and anti-inflammatory properties, respectively. Numerous h

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12

Abe, Noritaka, Hiroyuki Fujii, Akikazu Kakehi, and Motoo Shiro. "Revised Structures, 1-Methylene-1H-[1,4]thiazino[4,3-a]-benzimidazole and 10-Methylene-10H-imidazo[2,1-c][1,4]-benzothiazine Derivatives, for the Cycloadducts Accompanying Rearrangement from Imidazo[2,1-b]benzothiazole and Thiazolo [3,2-a] benzimidazole Derivatives with Propiolic Esters." Journal of Chemical Research 23, no. 5 (1999): 322–23. http://dx.doi.org/10.1177/174751989902300513.

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Formerly-proposed structures, thiazolo[3,2- a] [1,5]benzodiazepine and [1,4]diazepino[7,1- b]benzothiazole derivatives, cycloadducts from the reactions of thiazolo[3,2- a] benzimidazole and imidazo[2,1- b]benzothiazole derivatives with propiolic esters, are revised to methyl 2-[4-methyl-( E)-1 H-[1,4]thiazino[4,3- a]benzimidazol-1-ylidene)methoxycarbonylmethyl]-( E)-acrylate and methyl [2-methyl-( E)-10 H-imidazo[2,1- c] [1,4]benzothiazine-10-ylidene)-methoxycarbonylmethyl]-( E)-acrylate, respectively, whose structures are deduced by X-ray structure analysis.

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13

Refat, Hala M., and Khaled S. Mohamed. "Efficient and convenient synthesis of pyrido [2,1-b]benzothiazole, pyrimidopyrido[2,1-b]benzothiazole and benzothiazolo[3,2-a][1,8]naphthyridine derivatives." Heterocyclic Communications 21, no. 4 (2015): 219–24. http://dx.doi.org/10.1515/hc-2015-0018.

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AbstractNew 3-aryl-pyrido[2,1-b][1,3]benzothiazole derivatives 2a–e were synthesized in excellent yields via the reaction of benzothiazoleacetonitrile (1) with different aromatic aldehydes. The treatment of 2-(benzo[d]thiazol-2-yl)-3-(pyridin-4-yl)acrylonitrile (6) with malononitrile afforded 1-amino-3-(pyridin-4-yl)-3H-pyrido[2,1-b][1,3]benzothiazole-2,4-dicarbonitrile (7), which was allowed to react with a variety of reagents to provide pyrimido[5′,4′:5,6]pyrido[2,1-b][1,3]benzothiazole 8, 9 and [1,3]benzothiazolo[3,2-a][1,8]naphthyridine 10, 15 derivatives. All synthesized products were con

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14

Shainyan, Bagrat A., Larisa V. Zhilitskaya, and Nina O. Yarosh. "Synthetic Approaches to Biologically Active C-2-Substituted Benzothiazoles." Molecules 27, no. 8 (2022): 2598. http://dx.doi.org/10.3390/molecules27082598.

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Numerous benzothiazole derivatives are used in organic synthesis, in various industrial and consumer products, and in drugs, with a wide spectrum of biological activity. As the properties of the benzothiazole moiety are strongly affected by the nature and position of substitutions, in this review, covering the literature from 2016, we focus on C-2-substituted benzothiazoles, including the methods of their synthesis, structural modification, reaction mechanisms, and possible pharmacological activity. The synthetic approaches to these heterocycles include both traditional multistep reactions and

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15

Sharma, Diksha, Archana Sharma, Rakesh Pahwa, Avtar Chand Rana, and Prabodh Chander Sharma. "Design, synthesis, anti-infective and anti-cancer potential of thiazole based Pyrazoles bearing benzothiazole moiety." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4622–28. http://dx.doi.org/10.55522/jmpas.v11i2.2470.

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A new series of (E)-6-methyl-N-((3-phenyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-4-yl)methylene)benzo[d]thiazol-2-amine derivatives was developed. Structural investigation of the synthesized derivatives was carried out by several instrumental method of analysis like IR, and 1H-NMR spectroscopy. The titled analogues were examined for in-vitro anticancer and antiinfective activities. The biological findings specified that analogues 5a, 5b, 5d, 5e, 5f and 5g showed most potent antibacterial activity (MIC 62.5-250μg/mL) and 5a, 5e, 5f and 5g displayed most potent antifungal action (MIC 62.5-500 μg/mL

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16

Morsy, Mohamed A., Enas M. Ali, Mahmoud Kandeel, et al. "Screening and Molecular Docking of Novel Benzothiazole Derivatives as Potential Antimicrobial Agents." Antibiotics 9, no. 5 (2020): 221. http://dx.doi.org/10.3390/antibiotics9050221.

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The burden of antibiotic resistance necessitates a continued search for new antimicrobials. We evaluated the antimicrobial activities of novel benzothiazoles synthesized by our group. Antibacterial activity was evaluated in vitro in Staphylococcus aureus, Bacillus subtilis, and Escherichia coli, while the antifungal activity was tested in Candida albicans and Aspergillus niger, and expressed as the minimum inhibitory concentration (MIC; µg/mL). MIC values of benzothiazole compounds ranged from 25 to 200 µg/mL. Compounds 3 and 4 gave high antibacterial and moderate antifungal activities, while

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17

Mei, Haibo, Yanling Dai, Lingmin Wu, Vadim A. Soloshonok, Jianlin Han, and Yi Pan. "Mannich-Type Addition Reactions between Lithium Derivatives of Benzo[d]thiazoles andN-tert-Butylsulfinyl-3,3,3-trifluoroacetaldimine: Convenient Generalized Synthesis of Bis(benzothiazole)s." European Journal of Organic Chemistry 2014, no. 12 (2014): 2429–33. http://dx.doi.org/10.1002/ejoc.201400118.

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18

Yadav, Pradeep, and Y. C. Joshi. "Synthesis and Spectral Study of Novel Norfloxacin Derivatives." E-Journal of Chemistry 5, s2 (2008): 1154–58. http://dx.doi.org/10.1155/2008/357073.

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Reaction of [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolone-3-carboxylic acid (norfloxacin) with thiazole / benzothiazole diazonium chloride to get new piperazine substituted norfloxacin derivative. These norfloxacin derivatives were further condensed with variousβ-diketone to get novel acid derivatives of 1-Ethyl-6-fluoro-4-oxo-7- [4 (thiazol-2-yldiazenyl)-piperzin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid (6a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6 f-j). Structures of these compounds were

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19

Zi, You, Konrad Wagner, Fritz Schömberg, and Ivan Vilotijevic. "Selective C–H chalcogenation of thiazoles via thiazol-2-yl-phosphonium salts." Organic & Biomolecular Chemistry 18, no. 27 (2020): 5183–91. http://dx.doi.org/10.1039/d0ob00684j.

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Medicinally relevant substituted benzothiazoles and thiazoles are prepared under mild conditions by a regioselective C2–H chalcogenation via preparation of the phosphonium salt and the subsequent reaction with S- and Se-centered nucleophiles.

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20

Nayak, Janardhana, and Ramesh S. Bhat. "Synthesis, Antimicrobial and Corrosion Inhibition Studies of 1,3-Benzothiazole Derivatives." Asian Journal of Chemistry 35, no. 2 (2023): 375–78. http://dx.doi.org/10.14233/ajchem.2023.26885.

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With an emphasis on potential medicinal and corrosion inhibition applications, four N-(4-(substituted benzylidene)benzo[d]thiazol-2-amine were synthesized by the condensation of 2,3-dihydro-1,3- benzothiazol-2-amine with 4-substituted benzaldehydes. Nuclear magnetic resonance (NMR), infrared (IR) and mass spectroscopy were used to characterize the synthesized compounds. To assess the antibacterial activity of synthetic drugs, the conventional serial dilution approach has been used. The synthesized compounds showed excellent bioactivities comparable to those of a typical medication. The corrosi

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21

Belgath, Asma A., Aya M. Emam, Joshua Taujanskas, Richard A. Bryce, Sally Freeman, and Ian J. Stratford. "Discovery of Potent Benzothiazole Inhibitors of Oxidoreductase NQO2, a Target for Inflammation and Cancer." International Journal of Molecular Sciences 25, no. 22 (2024): 12025. http://dx.doi.org/10.3390/ijms252212025.

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Inhibitors of NQO2 (NRH: quinone oxidoreductase) have potential application in several areas of medicine and pharmacology, including cancer, neurodegeneration (PD and AD), stroke, and diabetes. Here, resveratrol, a known inhibitor of NQO2, was used as the lead by replacing the double bond in resveratrol with a benzothiazole scaffold. Fifty-five benzothiazoles were designed as NQO2 inhibitors and synthesized, comprising five benzothiazole series with 3,5-dimethoxy, 2,4-dimethoxy, 2,5-dimethoxy, 3,4-dimethoxy, and 3,4,5-trimethoxy substituents, the key synthetic step being a Jacobson cyclisation

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22

Soni, Vatsala, Meenakshi Sharma, Vandana Singh, Vaishali Soni, and Kishore D. "Comprehensive Study of Biological Aspects of Heteroring Annelated Benzothiazoles." International Journal of Science, Engineering and Management 9, no. 6 (2022): 1–6. http://dx.doi.org/10.36647/ijsem/09.06.a001.

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Heterocyclic chemicals are chemical structures which include at least a single carbon molecule plus at least one other element, such as sulphur, oxygen, or nitrogen, within the ring structure. Benzothiazoles are discussed in terms of synthesis methodologies, structural changes, chemical reactivity, and possible pharmaceutical effectiveness. This research relied upon secondary data obtained from the sources. The qualitative method was used to provide a section of such an evaluation which looked flawless and accurate. A handy methodology strategy is used in inquiry research. Heterocyclic compoun

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23

Yousuf, Sammer, Hina Siddiqui, Rabia Farooq, and M. Iqbal Choudhary. "2-[3-(1,3-Benzothiazol-2-yl)-2,2-dimethylpropyl]-2-methyl-2,3-dihydro-1,3-benzothiazole." Acta Crystallographica Section E Structure Reports Online 68, no. 8 (2012): o2349. http://dx.doi.org/10.1107/s1600536812029297.

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In the title compound, C20H22N2S2, the five-membered thiazole ring of the 2-methyl-2,3-dihydro-1,3-benzothiazole unit has an envelope conformation. The dihedral angle between the planar [maximum deviation of 0.014 (1) Å for the S atom] benzothiazole ring system and the benzene ring is 78.37 (12)°. Two intramolecular C—H...S hydrogen bonds are observed, forming rings of graph-set motifS(6). In the crystal, the molecules are consolidated in pairs through N—H...N hydrogen bonds and are arranged parallel to thebaxis.

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24

Mei, Haibo, Yanling Dai, Lingmin Wu, Vadim A. Soloshonok, Jianlin Han, and Yi Pan. "ChemInform Abstract: Mannich-Type Addition Reactions Between Lithium Derivatives of Benzo[d]thiazoles and N-tert-Butylsulfinyl-3,3,3-trifluoroacetaldimine: Convenient Generalized Synthesis of Bis(benzothiazole)s." ChemInform 46, no. 4 (2015): no. http://dx.doi.org/10.1002/chin.201504130.

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25

Naqvi, Arshi. "Synthesis, Characterization and Drug-Likeness Predictions of 1,3-Thiazole and Benzothiazole Derivatives." Oriental Journal of Chemistry 34, no. 6 (2018): 3134–39. http://dx.doi.org/10.13005/ojc/340660.

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Heterocyclic compounds bearing nitrogen and sulphur in the main skeleton are reported to be a bioactive group. Thiazole and benzothiazole moieties are biologically significant class of this group. This research focus on the synthesis and characterization of 1,3-thiazole and benzothiazole derivatives. Drug likeness predictions were also undertaken for these newly synthesized compounds.

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26

Nagaraju, Pallava, Pedavenkatagari Narayana Reddy, Pannala Padmaja, and Vinod G. Ugale. "Synthesis, Antiproliferative Activity and Molecular Docking of New Thiazole/Benzothiazole Fused Pyranopyrimidine Derivatives." Letters in Organic Chemistry 17, no. 12 (2020): 951–58. http://dx.doi.org/10.2174/1570178617666200319114611.

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A new class of 4H,5H-benzo[4,5]thiazolo[3,2-a]pyrano[2,3-d]pyrimidin-5-one and 5H,6Hpyrano[ 2,3-d]thiazolo[3,2-a]pyrimidin-5-one derivatives were synthesized via the one-pot threecomponent reaction of 2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one and 7-hydroxy-5Hthiazolo[ 3,2-a]pyrimidin-5-one to various aromatic aldehydes and malononitrile. This domino transformation involves the formation of pyranopyrimidine ring by the formation of three C–C bonds and one C– O bond a single synthetic operation. As the products precipitate out of the reaction, simple filtration is enough to gather th

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27

Azzam, Rasha A., Galal H. Elgemeie, Rasha E. Elsayed, and Peter G. Jones. "Crystal structure ofN-[6-amino-5-(benzo[d]thiazol-2-yl)-3-cyano-4-methylsulfanyl-2-oxo-1,2-dihydropyridin-1-yl]-4-methylbenzenesulfonamide dimethylformamide monosolvate." Acta Crystallographica Section E Crystallographic Communications 73, no. 12 (2017): 1820–22. http://dx.doi.org/10.1107/s2056989017015778.

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In the title compound, C21H17N5O3S3·C3H7NO, the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings subtend an interplanar angle of 39.86 (4)°. The pyridone and benzothiazyl rings are linked by the intramolecular hydrogen bond N—Hamine...Nthiazole. The DMF O atom accepts two classical hydrogen bonds. The molecules are linked by hydrogen bonds and an S...O contact to form layers parallel to thebcplane.

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28

Morscher, Alexandra, Marcus V. N. de Souza, James L. Wardell, and William T. A. Harrison. "Expected and unexpected products of reactions of 2-hydrazinylbenzothiazole with 3-nitrobenzenesulfonyl chloride in different solvents." Acta Crystallographica Section E Crystallographic Communications 74, no. 5 (2018): 673–77. http://dx.doi.org/10.1107/s2056989018005595.

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The syntheses and crystal structures of 2-[2-(propan-2-ylidene)hydrazinyl]-1,3-benzothiazol-3-ium 3-nitrobenzenesulfonate (C10H12N2S+·C6H4NO5S−), (I), 2-[2-(3-nitrobenzenesulfonyl)hydrazinyl]-1,3-benzothiazole (C13H10N4O4S2), (II) and 2-[2-(3-nitrobenzenesulfonyl)hydrazinyl]-1,3-benzothiazol-3-ium 3-nitrobenzenesulfonate (C13H11N4O4S2 +·C6H4NO5S−), (III) are reported. Salt (I) arose from an unexpected reaction of 2-hydrazinylbenzothiazole with the acetone solvent in the presence of 3-nitrobenzenesulfonyl chloride, whereas (II) and (III) were recovered from the equivalent reaction carried out i

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29

Zhu, Xiaoming, Yuzhong Yang, Genhua Xiao, Jianxin Song, Yun Liang, and Guobo Deng. "Double C–S bond formation via C–H bond functionalization: synthesis of benzothiazoles and naphtho[2,1-d]thiazoles from N-substituted arylamines and elemental sulfur." Chem. Commun. 53, no. 87 (2017): 11917–20. http://dx.doi.org/10.1039/c7cc07366f.

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30

Liu, Li, Chen Tan, Rong Fan, et al. "I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles." Organic & Biomolecular Chemistry 17, no. 2 (2019): 252–56. http://dx.doi.org/10.1039/c8ob02826e.

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31

Zhang, Hui-Jun, Weidong Lin, Zhengjian Wu, Wenqing Ruan, and Ting-Bin Wen. "Correction: Silver-mediated direct phosphorylation of benzothiazoles and thiazoles with diarylphosphine oxides." Chemical Communications 51, no. 94 (2015): 16871. http://dx.doi.org/10.1039/c5cc90492g.

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32

Moreira, Ryan E., Geoffrey S. Sinclair, and Derek J. Schipper. "Oxidative ring-opening of benzothiazole derivatives." Canadian Journal of Chemistry 97, no. 5 (2019): 360–65. http://dx.doi.org/10.1139/cjc-2018-0459.

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An oxidative ring opening of benzothiazole to an acylamidobenzene sulfonate ester using alcohol solvents and magnesium monoperxoyphthalate hexahydrate has been described. Under the established conditions, the reaction produces synthetically significant yields with a variety of benzothiazole derivatives. A sulfonate ester intermediate suggests that the reaction proceeds via thiazole ring opening followed by thiol oxidation.

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Heda, Kavita. M. "Newly synthesized compounds from 2- hydrazino benzothiazole: Characterization, and evaluation of their antibacterial potential." International Journal of Advance and Applied Research 5, no. 23 (2024): 291–94. https://doi.org/10.5281/zenodo.13622529.

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Abstract:Serial of 1-tetra-O-benzoyl-β-D-glucosyl-3-(2)-hydrazino-1, 3-substituted benzothiozolyl thiocarbamide has been synthesized by the interaction  of   two pharmocophores,  tetra-O-benzoyl-β-D-glucosyl isothiocyanates and amine substituted 2-hydrazino-1,3-benzothiazoles in acetone medium. The reaction mixture was kept at room temp for 24 hrs. In acetone medium. Acetone is evaporated then product is recrystallised by petroleum ether (60-80%).  Benz-fused compounds have been employed in the synthesis of various compounds which show very potential pharmacologic

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Mandal, Swapan Kumar, Rabindra Nath Datta, and Dipak Kumar Basu. "Studies on Cure Synergism—Part I: Effect of Bis(Diisopropyl) Thiophosphoryl Disulfide and Thiazole-Based Accelerators in the Vulcanization of NR." Rubber Chemistry and Technology 62, no. 4 (1989): 569–84. http://dx.doi.org/10.5254/1.3536260.

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Abstract The effect of the synergistic combinations containing diisopropyl thiophosphoryl disulfide (DIPDIS) and a thiazole type of accelerator on the vulcanization of NR has been investigated. MBT, N-oxydiethylene-2-benzothiazole sulfenamide (OBTS), and N-oxydiethylene-2-benzothiazole disulfide (OBDS) represent the thiazole-based accelerators. It has been established from the hplc study that diisopropylthiophosphoryl benzothiazole disulfide (DIBDS) is formed in the synergistic systems along with other rubber additives during the early part of cure. In this exploratory study, it has been obser

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35

P. Kavitha and N. Vijayakumari. "SYNTHESIS AND CHARACTERIZATION OF BENZOTHIAZOLE SCHIFF BASES BASED METAL COMPLEXES AND THEIR BIOLOGICAL APPLICATIONS." RASAYAN Journal of Chemistry 18, no. 02 (2025): 1170–76. https://doi.org/10.31788/rjc.2025.1829261.

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A new benzothiazole Schiff base ligand named (E)-N-(6-((2-hydroxy-5-methylbenzylidene)amino)benzo[d]thiazol-2- yl)cyclohexane-carboxamide (BSB) was prepared through the condensation reaction of N-(6-aminobenzo[d]thiazol2-yl)cyclohexane-carboxamide with substituted aldehyde. Mass, FT-IR, NMR, and spectral techniques confirmed the synthesized ligand. The resulting compound was tested with the coordination behavior of a series of various d-block metal ions named Cu2+, Zn2+, Co2+, and Ni2+, with the prepared (BSB) reported. The bonding behavior and the complexes' performance have been assumed as p

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Xu, Zhenhua, Huawen Huang, Hongbiao Chen, and Guo-Jun Deng. "Catalyst- and additive-free annulation/aromatization leading to benzothiazoles and naphthothiazoles." Organic Chemistry Frontiers 6, no. 17 (2019): 3060–64. http://dx.doi.org/10.1039/c9qo00592g.

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Giridhar, Thota, Woosum Cho, Young-Hoon Kim, Tae-Hee Han, Tae-Woo Lee, and Sung-Ho Jin. "A systematic identification of efficiency enrichment between thiazole and benzothiazole based yellow iridium(iii) complexes." J. Mater. Chem. C 2, no. 44 (2014): 9398–405. http://dx.doi.org/10.1039/c4tc01514b.

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Bhat, Mahesh, and Shiddappa Lagamappa Belagali. "Structural Activity Relationship and Importance of Benzothiazole Derivatives in Medicinal Chemistry: A Comprehensive Review." Mini-Reviews in Organic Chemistry 17, no. 3 (2020): 323–50. http://dx.doi.org/10.2174/1570193x16666190204111502.

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:Benzothiazole (1, 3-benzothiazole) is one of the heterocyclic compounds, which is a weak base having varied biological activities. The unique methine center present in the thiazole ring makes benzothiazole as the most important heterocyclic compound. It is a common and integral structure of many natural and synthetic bioactive molecules. Benzothiazole derivatives show a variety of activities, with less toxic effects and their derivatives showed enhanced activities, which has proven Benzothiazole scaffold as one of the important moieties in medicinal chemistry. Benzothiazole ring containing co

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Rouf, Abdul, and Cihangir Tanyeli. "Bioactive thiazole and benzothiazole derivatives." European Journal of Medicinal Chemistry 97 (June 2015): 911–27. http://dx.doi.org/10.1016/j.ejmech.2014.10.058.

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40

V. Gadhave, Ranjit, Sachin S. Khade, Yogita S. Ozarde, Somdatta Y. Chaudhari, Arti G. Swami, and Mukesh K. Meena. "DESIGN, SYNTHESIS AND EVALUATION OF N-(BENZO[D]THIAZOL-2-YL)-2-OXO2H-CHROMENE-3-CARBOXAMIDE DERIVATIVES AS POTENTIAL ANTIOXIDANT AND ANTIBACTERIAL AGENTS." Indian Drugs 59, no. 10 (2022): 20–29. http://dx.doi.org/10.53879/id.59.10.13222.

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This research is focused on designing, synthesis and biological evaluation of a series of coumarin based benzothiazole derivatives. The ligands were identified by docking study for antioxidant and antibacterial potential using target proteins PDB:4H1J and PDB:3G75, respectively. The target molecules were synthesized as a series of substituted N-(benzothiazol-2-yl)-2-oxo-chromene-3-carboxamides (7a–h) by condensation of substituted benzo[d]thiazol-2-amines with in situ synthesized substituted 2-oxo-2H-chromene-3-carbonyl chlorides. Infrared spectroscopy and 1 H- nuclear magnetic resonance spect

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41

Chen, Yaping, Ruyan Chen, Jinhuai Xu, Yongqi Tian, Jiangping Xu, and Yonghong Liu. "Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp. SCSIOS02F49." Molecules 23, no. 11 (2018): 2844. http://dx.doi.org/10.3390/molecules23112844.

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Two novel altenusin-thiazole hybrids named altenusinoides A and B (1 and 2), a new benzothiazole derivative (3), and three known altenusin derivatives (4–6) have been obtained from the solid culture of the marine sponge-derived fungal strain, Alternaria sp. SCSIOS02F49. The structures of these new compounds were characterized by NMR, HRESIMS, and X-ray single crystal analysis. Compounds 1 and 2 possess an unusual altenusin-thiazole-fused skeleton core (6/6/5), and compound 3 represents the first benzothiazole derivative from fungi. Compounds 4 and 5 showed significant DPPH free-radical-scaveng

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Choudhary, Suresh, Naresh Kalra, and G. Jeyabalan. "Synthesis, Characterization and Pharmacological evaluation of some newer Benzothiazole derivatives." Indian Journal of Pharmaceutical and Biological Research 6, no. 02 (2018): 31–36. http://dx.doi.org/10.30750/ijpbr.6.2.6.

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The objective of the present work is to develop safer new chemical entities that show good anticonvulsant effects and antimicrobial actions. The current work describes the synthesis of Benzothiazole derivatives with encouraging anticonvulsant activity against MES and scPTZ tests with interesting pattern of antimicrobial effects. The synthesized Benzothiazole derivatives could be considered as lead molecule for the development of therapeutic agents. Many polycyclic and fused ring systems containing the thiazolenucleus(I) are well known. The most important is bicyclic system wherein the second r

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Shafi, S. Syed, R. Rajesh, and S. Senthilkumar. "Synthesis and Biological Properties of New Piperidine Substituted Benzothiazole Derivatives." Asian Journal of Organic & Medicinal Chemistry 6, no. 3 (2021): 181–85. http://dx.doi.org/10.14233/ajomc.2021.ajomc-p333.

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In present work, ethyl 2-aminobenzo[d]thiazole-6-carboxylate was reacted to piperidine using copper(II) bromide to get ethyl 2-(piperidin-1-yl)benzo[d]thiazole-6-carboxylate. The reaction of ethyl 2-(piperidin- 1-yl)benzo[d]thiazole-6-carboxylate with NaOH produces 2-(piperidin-1-yl)benzo[d]thiazole-6- carboxylic acid. The inter-mediate 2-(piperidin-1-yl)benzo[d]thiazole-6-carboxylic acid have been isolated as stable compounds. The chemical structures of synthesized compounds were established based on the 1H & 13C NMR and IR spectral data. The mass of the novel compounds was established wi

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Paraskevas, Konstantinos, Christos Iliopoulos-Tsoutsouvas, Eleftheria A. Georgiou, and Ioannis K. Kostakis. "5-Chloro-6-oxo-6H-xantheno[4,3-d]thiazole-2-carbonitrile." Molbank 2022, no. 4 (2022): M1489. http://dx.doi.org/10.3390/m1489.

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Xanthones and benzothiazoles are important classes of heterocyclic compounds with versatile biological activities. Herein, we describe a straightforward and scalable synthesis of 5-chloro-6-oxo-6H-xantheno[4,3-d]thiazole-2-carbonitrile, a thiazole-fused xanthone, via a six-step approach, using Appel’s salt for the synthesis of the thiazole ring. The thiazole-fused xanthone was fully characterized employing 1H and 13C NMR spectra, using direct and long-range heteronuclear correlation experiments (HMBC and HMQC).

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Sharma, Neetesh Kumar, and Raghvendra Singh Bhadauria. "Synthesis and Biological Evaluation of 1-(6-bromobenzo [d]thiazol-2-yl)-2-(disubstituted methylene) hydrazine derivatives." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 577–86. http://dx.doi.org/10.22270/jddt.v9i4-a.3520.

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Synthesis of a series of various 1-(6-bromobenzo[d]thiazol-2-yl)-2-(disubstitutedmethylene)hydrazine derivatives (7a-7e)have been done. Synthesis of a series of intermediates (3 and 5) have been also done, 6-bromo-1,3-benzothiazole-2-amine (3), 2-hydrazino-6-bromo-1, 3-benzothiazole (5) and final product (7a-7e), 1-(6-bromobenzo[d]thiazol-2-yl)-2-(diphenylmethylene) hydrazine (7a), 1-(6-bromobenzo [d]thiazol-2-yl)-2-(propan-2-ylidene) hydrazine (7b), (E)-2-(butan-2-ylidene)-1-(6-bromobenzo[d]thiazol-2-yl)hydrazine (7c), (Z)-1-(6-bromobenzo[d]thiazol-2-yl)-2-(cyclohexylmethylene) hydrazine (7d)

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Sharma, Neetesh Kumar, and Raghvendra Singh Bhadauria. "Synthesis and Biological Evaluation of 1-(6-chlorobenzo [d]thiazol-2-yl)-2-(disubstituted methylene) hydrazine derivatives." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 561–72. http://dx.doi.org/10.22270/jddt.v9i4-a.3515.

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Synthesis of a series of various 1-(6-chlorobenzo[d]thiazol-2-yl)-2-(disubstitutedmethylene)hydrazine derivatives (7a-7e)have been done. Synthesis of a series of intermediates (3 and 5) have been also done, 6-Chloro-2-amine-1,3-benzothiazole (3), 2-hydrazino-6-chloro-1, 3-benzothiazole (5) and final product (7a-7e), 1-(6-chlorobenzo[d]thiazol-2-yl)-2-(diphenylmethylene) hydrazine (7a), 1-(6-chlorobenzo [d]thiazol-2-yl)-2-(propan-2-ylidene) hydrazine (7b), (E)-2-(butan-2-ylidene)-1-(6-chlorobenzo[d]thiazol-2-yl)hydrazine (7c), (Z)-1-(6-chlorobenzo[d]thiazol-2-yl)-2-(cyclohexylmethylene) hydrazi

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Pathak, Nandini, Ekta Rathi, Nitesh Kumar, Suvarna G. Kini, and C. Mallikarjuna Rao. "A Review on Anticancer Potentials of Benzothiazole Derivatives." Mini-Reviews in Medicinal Chemistry 20, no. 1 (2020): 12–23. http://dx.doi.org/10.2174/1389557519666190617153213.

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: Benzothiazole is an organic compound bearing a heterocyclic nucleus (thiazole) which imparts a broad spectrum of biological activities to it. The significant and potent activity of benzothiazole moiety influenced distinctively by nature and position of substitutions. This review summarizes the effect of various substituents in recent trends and approaches to design and develop novel benzothiazole derivatives for anticancer potential in different cell lines by interpreting the Structure- Activity Relationship (SAR) and mechanism of action of a wide range of derivatives. The list of derivative

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48

Attiya, Hanaa G., Ruwaidah S. Saeed, Fatimah A. Hasheem, and Muna S. Al-Rawi. "Synthesis of Few New Carrier Polymers Derived from 2-hydrazinylbenzo[d]thiazole." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1792–96. http://dx.doi.org/10.25258/ijddt.12.4.50.

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2-hydrazinylbenzo[d]thiazole compound [1] is produced from reaction of 2-mercapto-benzothiazole with hydrazine hydride in ethanol. Compound [1] reacted with maleic anhydride in DMF to produce (Z)-4-(2-(benzo[d] thiazol-2yl) hydrazinyl)-4-oxobut-2-enoic acid [compound (2)]. While the treatment of compound [2] with the ammonium persulfate (NH4)2S2O8 (as the initiator) in order to produce compound [3], then compound [3] reacted with thionyl chloride in benzene to produce compound [4], finally compound [4] reaction with various drugs: cephalexin, amoxicillin, sulfamethizole, elecoxib obtained poly

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Gholami, Mahnaz D., Sergei Manzhos, Prashant Sonar, Godwin A. Ayoko, and Emad L. Izake. "Dual chemosensor for the rapid detection of mercury(ii) pollution and biothiols." Analyst 144, no. 16 (2019): 4908–16. http://dx.doi.org/10.1039/c9an01055f.

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A new benzothiazole azo dye [(E)-1-((6-methoxybenzo[d]thiazole-2-yl)diazenyl)naphthalene-2,6-diol] (also known as “BAN”), has been synthesised and used as a chemosensor for the rapid and selective detection of mercury(ii) ions in water.

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Saprykina, V. A., V. I. Vinogradova, R. F. Ambartsumova, T. F. Ibragimov, and Kh M. Shakhidoyatov. "Thiazole and benzothiazole derivatives of cytisine." Chemistry of Natural Compounds 42, no. 4 (2006): 470–72. http://dx.doi.org/10.1007/s10600-006-0182-7.

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