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Journal articles on the topic 'Benzoylhydrazones'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

SAYAJI, RAO, and HUSSAIN REDDY K. "Ligand-imposed Structural Features of Transition Metal Complexes with Heterocyclic Benzoylhydrazones." Journal of Indian Chemical Society Vol. 74, Jul 1997 (1997): 532–34. https://doi.org/10.5281/zenodo.5901464.

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Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515 003 <em>Manuscript received 16 November 1995, revised 27 February 1996, accepted 14 May 1996</em> Copper(II), nickel(II) and cobalt(II) complexes of some benzoylhydrazones, viz. furyl-2-methylketone benzoylhydrazone (FMBH) and thiophene-2-methylketone benzoylhydrazone (TMBH) have been synthesised. The molar conductivity data show them to be non-electrolytes. The tridentate nature of the ligands is inferred from ir spectral studies. The magnetic moment values together with electronic spectral data suggest an octahedral struc

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2

Dilman, Alexander D., Dmitry E. Arkhipov, Vitalij V. Levin, et al. "Trifluoromethylation ofN-Benzoylhydrazones." Journal of Organic Chemistry 73, no. 14 (2008): 5643–46. http://dx.doi.org/10.1021/jo800782w.

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3

Matveeva, E. D., T. A. Podrugina, I. N. Kolesnikova, and N. S. Zefirov. "Benzoylhydrazones in catalytic hydrophosphorylation." Russian Chemical Bulletin 59, no. 2 (2010): 411–17. http://dx.doi.org/10.1007/s11172-010-0094-3.

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4

Charton, Marvin, Grazyna R. Ciszewska, James Ginos, et al. "Quantitative Structure Activity Relationships for Substituted Naloxone Benzoylhydrazones. 4′-substituted Naloxone Benzoylhydrazones." Quantitative Structure-Activity Relationships 17, no. 02 (1998): 109–21. http://dx.doi.org/10.1002/(sici)1521-3838(199804)17:02<109::aid-qsar109>3.0.co;2-1.

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5

Charton, Marvin, Grazyna R. Ciszewska, James Ginos, et al. "Quantitative Structure Activity Relationships for Substituted Naloxone Benzoylhydrazones. 4′-substituted Naloxone Benzoylhydrazones." Quantitative Structure-Activity Relationships 17, no. 02 (1998): 109–21. http://dx.doi.org/10.1002/(sici)1521-3838(199804)17:02<109::aid-qsar109>3.3.co;2-t.

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6

Ma, Wei-Wei, Chao Yang, Qiang Xie, and Yun-He Xu. "Dienylation of N-benzoylhydrazones with CF₃-substituted homoallenylboronates in water." Organic & Biomolecular Chemistry 20, no. 7 (2022): 1386–90. http://dx.doi.org/10.1039/d1ob02335g.

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7

Nikolaeva, O. G., Yu V. Revinskii, K. S. Tikhomirova, O. I. Dmitrieva, A. D. Dubonosov, and V. A. Bren. "CHEMOSENSOR BENZOYLHYDRAZONES OF COUMARIN ALDEHIDES." Science in the South of Russia 14, no. 2 (2018): 14–19. http://dx.doi.org/10.23885/2500-0640-2018-14-2-14-19.

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8

Ton, Quoc Cuong, Michael Bolte, and Ernst Egert. "Structural similarities among eight benzoylhydrazones." Acta Crystallographica Section C Structural Chemistry 70, no. 9 (2014): 912–19. http://dx.doi.org/10.1107/s2053229614018658.

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The crystal structures of eight benzoylhydrazones with different substituents have been investigated, namely 1-benzoyl-2-(propan-2-ylidene)hydrazone, C10H12N2O, (I), 1-benzoyl-2-(1-cyclohexylethylidene)hydrazone, C15H20N2O, (II), 1-benzoyl-2-[1-(naphthalen-2-yl)ethylidene]hydrazone, C19H16N2O, (III), 1-benzoyl-2-(1-cyclohexylbenzylidene)hydrazone, C20H22N2O, (IV), 1-benzoyl-2-(1-phenylbenzylidene)hydrazone, C20H16N2O, (V), 1-benzoyl-2-[1-(4-chlorophenyl)benzylidene]hydrazone, C20H15ClN2O, (VI), 1-benzoyl-2-(4-hydroxybenzylidene)hydrazone methanol monosolvate, C14H12N2O2·CH3OH, (VII), and 1-ben

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9

Gatto, C. C., E. Schulz Lang, A. Kupfer, A. Hagenbach, D. Wille, and Ulrich Abram. "Dioxouranium Complexes with Acetylpyridine Benzoylhydrazones and Related Ligands." Zeitschrift für anorganische und allgemeine Chemie 630, no. 5 (2004): 735–41. http://dx.doi.org/10.1002/zaac.200400024.

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10

Ciszewska, Grazyna R., James A. Ginos, Marvin Charton, et al. "Synthesis and characterization of substituted benzoylhydrazones of naloxone." Synapse 24, no. 2 (1996): 193–201. http://dx.doi.org/10.1002/(sici)1098-2396(199610)24:2<193::aid-syn11>3.0.co;2-#.

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11

Samus', N. M., V. I. Tsapkov, and A. V. Kerner. "Coordination Compounds of Copper(II) with Benzoylhydrazones of Substituted Salicylaldehydes." Russian Journal of General Chemistry 73, no. 10 (2003): 1611–15. http://dx.doi.org/10.1023/b:rugc.0000016032.80593.ec.

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12

NAGARAJU, KOPPANATHI, ANINDITA SARKAR, and SAMUDRANIL PAL. "Non-oxo vanadium(IV) complexes with acetylacetone 4-R-benzoylhydrazones." Journal of Coordination Chemistry 66, no. 1 (2012): 77–88. http://dx.doi.org/10.1080/00958972.2012.747089.

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13

Ajayeoba, Temitope A., Joseph O. Woods, Ayowole O. Ayeni, et al. "Synthesis, crystallographic, computational and molecular docking studies of new acetophenone-benzoylhydrazones." Journal of Molecular Structure 1237 (August 2021): 130275. http://dx.doi.org/10.1016/j.molstruc.2021.130275.

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14

Berger, Richard, Keiko Duff, and James L. Leighton. "Enantioselective Allylation of Ketone-Derived Benzoylhydrazones: Practical Synthesis of Tertiary Carbinamines." Journal of the American Chemical Society 126, no. 18 (2004): 5686–87. http://dx.doi.org/10.1021/ja0486418.

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15

Nikolova-Mladenova, Boryana, Rositsa Mihaylova, Mariyana Atanasova, Zvetanka Zhivkova, and Irini Doytchinova. "Salicylaldehyde Benzoylhydrazones with Anticancer Activity and Selectivity: Design, Synthesis, and In Vitro Evaluation." Molecules 30, no. 5 (2025): 1015. https://doi.org/10.3390/molecules30051015.

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Dimethoxy derivatives of salicylaldehyde benzoylhydrazone containing a methoxy group on both aromatic rings were designed and synthesized. The compounds were obtained in high yields, and their structures were confirmed by elemental analysis and various spectral techniques. In vitro evaluation of dimethoxy hydrazones demonstrated potent activity against the leukemic cell lines at low micro- and nanomolar concentrations. Remarkably, two dimethoxy analogs showed exceptional antileukemic selectivity, with no toxicity observed in normal human embryonic kidney HEK-293 cells. In silico modeling ident

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16

Liu, Jianchao, Zeping Cui, and Hongwu He. "Synthesis and Pesticidal Activity of 3-(2-Chloro-4-trifluoromethyl)phenoxy Benzoylhydrazones." Chinese Journal of Organic Chemistry 32, no. 10 (2012): 1925. http://dx.doi.org/10.6023/cjoc201204022.

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17

Mesubi, M. Adediran, and B. Ayo Omotowa. "Synthesis and Structural Characterization OP Cobalt (II) Complexes of Some Salicylaldehyde Benzoylhydrazones." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 23, no. 3 (1993): 435–51. http://dx.doi.org/10.1080/15533179308016648.

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18

Kim, Sung Jun, and Doo Ok Jang. "Indium-Mediated Catalytic Enantioselective Allylation ofN-Benzoylhydrazones Using a Protonated Chiral Amine." Journal of the American Chemical Society 132, no. 35 (2010): 12168–69. http://dx.doi.org/10.1021/ja1035336.

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19

Ferwanah, Abdel-Rahman S. "1,3-Dipolar Cycloaddition Reaction ofC-Acetyl-N-arylnitrilimines with Selected Aliphatic Benzoylhydrazones." Synthetic Communications 33, no. 2 (2003): 243–51. http://dx.doi.org/10.1081/scc-120015707.

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20

ASHOK, KUMAR, K. SAXBNA K., SRIVASTAVA K., LATA S., and S. SAXENA R. "Newer Quinolines as Cardiovascular Agents." Journal of Indian Chemical Society Vol. 68, Mar 1991 (1991): 138–41. https://doi.org/10.5281/zenodo.5955348.

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Department of Pharmacology, L.L.R.M. Medical College, Meerut-250 004 <em>Manuscript received 24 May</em> <em>1990, revised 6 November 1990, accepted 16 February 1991</em> 1- (7- Triiluoromethyl- 4 -hydroxyquinoline-benzamido) - 5- aryl-∆<sup>2</sup>-triazolines (4a — h),' 147-trilluoromethy1-4- hydroxyquinoline-3-benzamido)-2-oxo-4-arylazetidin2-ones (5a — h), 1'-(7-trifluoromethy1-4-hydroxyquinoline-3-benzamido)-3<em>'</em>- methyl-2'- oxothiazolidinones (6a— h) were synthesised by cycloaddition of diazomethane, monochloroacetyl chloride and th

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21

Hristova-Avakumova, Nadya G., Evgenia P. Valcheva, Neda O. Anastassova, et al. "In vitro and in silico studies of radical scavenging activity of salicylaldehyde benzoylhydrazones." Journal of Molecular Structure 1245 (December 2021): 131021. http://dx.doi.org/10.1016/j.molstruc.2021.131021.

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22

Shirakawa, Seiji, Richard Berger, and James L. Leighton. "Enantioselective Friedel−Crafts Alkylations with Benzoylhydrazones Promoted by a Simple Strained Silacycle Reagent." Journal of the American Chemical Society 127, no. 9 (2005): 2858–59. http://dx.doi.org/10.1021/ja042522a.

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23

Umarov, B. B., K. G. Avezov, M. A. Tursunov, N. G. Sevinchov, N. A. Parpiev, and G. G. Aleksandrov. "Synthesis and crystal structure of nickel(II) complex based on 2-trifluoroacetylcycloalkanone benzoylhydrazones." Russian Journal of Coordination Chemistry 40, no. 7 (2014): 473–76. http://dx.doi.org/10.1134/s1070328414070094.

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24

García-Flores, Fred, Luz S. Flores-Michel, and Eusebio Juaristi. "Asymmetric allylation of N-benzoylhydrazones promoted by novel C2-symmetric bis-sulfoxide organocatalysts." Tetrahedron Letters 47, no. 47 (2006): 8235–38. http://dx.doi.org/10.1016/j.tetlet.2006.09.113.

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25

Tan, Shiow Jin, Mahasin Alam Sk, Peter Peng Foo Lee, Yaw Kai Yan, and Kok Hwa Lim. "Structural requirements of salicylaldehyde benzoylhydrazones and their Cu(II) complexes for anticancer activity." Canadian Journal of Chemistry 90, no. 9 (2012): 762–75. http://dx.doi.org/10.1139/v2012-053.

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Salicylaldehyde benzoylhydrazone (H2sb) has a variety of biological activities including anticancer activity. The Cu(II) complexes of H2sbs possess enhanced anticancer activity as compared with their free ligands. A quantitative structure–activity relationship (QSAR) analysis was performed on a series of H2sb ligands and their corresponding Cu(II) complexes to capture the structural requirements that are responsible for the bioactivity. The predictive QSAR models were developed using statistical techniques such as multiple linear regression (MLR) and principal component regression analysis (PC

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26

Hirabayashi, Ryoji, Chikako Ogawa, Masaharu Sugiura, and Shū Kobayashi. "Highly Stereoselective Synthesis of Homoallylic Amines Based on Addition of Allyltrichlorosilanes to Benzoylhydrazones." Journal of the American Chemical Society 123, no. 39 (2001): 9493–99. http://dx.doi.org/10.1021/ja011125m.

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27

Samus', N. M., V. I. Prisakar', V. I. Tsapkov, S. A. Buracheva, and A. P. Gulya. "Synthesis and Antimicrobial Activity of the Complexes of 3d-Metals with Substituted Salicylaldehyde Benzoylhydrazones." Pharmaceutical Chemistry Journal 38, no. 7 (2004): 373–75. http://dx.doi.org/10.1023/b:phac.0000048436.48548.47.

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28

Santos, Ane F., Isabella P. Ferreira, Carlos B. Pinheiro, Jacqueline A. Takahashi, Letícia R. Teixeira, and H. Beraldo. "Silver(I) complexes with 2,6-diacetylpyridine- bis (benzoylhydrazones): Antifungal activity and interaction with DNA." Polyhedron 138 (December 2017): 270–76. http://dx.doi.org/10.1016/j.poly.2017.09.019.

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29

Nagaraju, Koppanathi, and Samudranil Pal. "Ruthenium(III) cyclometallates: Regioselective metallation of 1-pyrenyl in 1-pyrenaldehyde 4-R-benzoylhydrazones." Journal of Organometallic Chemistry 737 (August 2013): 7–11. http://dx.doi.org/10.1016/j.jorganchem.2013.03.040.

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30

Nosova, E. V., A. A. Chupakhin, G. N. Lipunova, P. A. Slepukhin, M. S. Valova, and V. N. Charushin. "Syntheses, structures, and photophysical properties of ZnII and CdII metal complexes based on benzoylhydrazones." Russian Chemical Bulletin 63, no. 6 (2014): 1344–49. http://dx.doi.org/10.1007/s11172-014-0601-z.

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31

Nasrullah, Muhammad, Misbahul Ain Khan, Muhammad Naeem Khan, et al. "Diaryl Pyrazole-4-carbaldehyde Benzoylhydrazones Metal Complexes: Synthesis and Their Antibacterial and Antioxidant Screening." Asian Journal of Chemistry 25, no. 1 (2013): 419–23. http://dx.doi.org/10.14233/ajchem.2013.13131.

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32

Emami, Saeed, Zahra Esmaili, Gholamreza Dehghan, et al. "Acetophenone benzoylhydrazones as antioxidant agents: Synthesis, in vitro evaluation and structure-activity relationship studies." Food Chemistry 268 (December 2018): 292–99. http://dx.doi.org/10.1016/j.foodchem.2018.06.083.

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33

Garcia-Vargas, M., M. Milla, J. L. Hidalgo De Cisneros, and J. M. Bautista Rodriguez. "Spectral (u.v.-vis, i.r.MS), electrochemical and metallochromic properties of 2-hydroxy-benzoylhydrazones of acetylpyridines." Spectrochimica Acta Part A: Molecular Spectroscopy 43, no. 3 (1987): 355–60. http://dx.doi.org/10.1016/0584-8539(87)80117-4.

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34

MESUBI, M. A., and B. A. OMOTOWA. "ChemInform Abstract: Synthesis and Structural Characterization of Cobalt(II) Complexes of Some Salicylaldehyde Benzoylhydrazones." ChemInform 24, no. 30 (2010): no. http://dx.doi.org/10.1002/chin.199330235.

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35

Nikolova-Mladenova, Boryana, Silvia Angelova, and Georgi Momekov. "Gallium (III) Complexes with 5-Bromosalicylaldehyde Benzoylhydrazones: In Silico Studies and In Vitro Cytotoxic Activity." Molecules 27, no. 17 (2022): 5493. http://dx.doi.org/10.3390/molecules27175493.

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Gallium (III) complexes with the ligands 5-bromosalicylaldehyde-4-hydroxybenzoylhydrazone and 5-bromosalicylaldehyde isonicotinoylhydrazone were synthesized to receive compounds with improved antiproliferative action. Compounds were characterized by elemental analysis, IR, and NMR spectroscopy. Density functional theory calculations with Becke’s 3-parameter hybrid functional and 6-31+G(d,p) basis set were carried out to investigate the structural features of the ligands and Ga(III) complexes. Cytotoxic screening by MTT-dye reduction assay was carried out using cisplatin and melphalan as refere

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36

Burlov, A. S., V. G. Vlasenko, B. V. Chal’tsev, Yu V. Koshchienko, and S. I. Levchenkov. "Metal Complexes of Aroyl(acyl)benzoylhydrazones of Aromatic Aldehydes and Ketones: Coordination Modes and Properties." Russian Journal of Coordination Chemistry 47, no. 7 (2021): 439–72. http://dx.doi.org/10.1134/s1070328421070010.

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37

Xu, Yan, Peng Lei, Yun Ling, Shengwen Wang, and Xinling Yang. "Design, Synthesis and Biological Activity of Novel (3-Substituted phenyl-2-propen-1-ylidene)-benzoylhydrazones." Chinese Journal of Organic Chemistry 34, no. 6 (2014): 1118. http://dx.doi.org/10.6023/cjoc201401034.

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38

Kim, Sung Jun, and Doo Ok Jang. "Retraction of “Indium-Mediated Catalytic Enantioselective Allylation of N-Benzoylhydrazones Using a Protonated Chiral Amine”." Journal of the American Chemical Society 136, no. 33 (2014): 11850. http://dx.doi.org/10.1021/ja5018909.

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39

García-Flores, Fred, Luz S. Flores-Michel, and Eusebio Juaristi. "Corrigendum to “Asymmetric allylation of N-benzoylhydrazones promoted by novel C2-symmetric bis-sulfoxide organocatalysts”." Tetrahedron Letters 48, no. 18 (2007): 3315. http://dx.doi.org/10.1016/j.tetlet.2007.02.122.

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40

Commeiras, Laurent, Samuel C. Woodcock, Jack E. Baldwin, Robert M. Adlington, Andrew R. Cowley, and Peter J. Wilkinson. "New access to the 1H-pyrazolo[4,3-c]pyridine core from bis-acetylenic-N-benzoylhydrazones." Tetrahedron 60, no. 4 (2004): 933–38. http://dx.doi.org/10.1016/j.tet.2003.11.036.

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41

Chernitsa, B. V., A. Yu Ershov, D. A. Komarova, et al. "Cyclic structure of n-methyl- 2-aminobenzoyl- and 2-mercapto- benzoylhydrazones of fatty- aromatic aldehydes." Chemistry of Heterocyclic Compounds 45, no. 11 (2009): 1388–90. http://dx.doi.org/10.1007/s10593-010-0437-x.

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42

Hirabayashi, Ryoji, Chikako Ogawa, Masaharu Sugiura, and Shu Kobayashi. "ChemInform Abstract: Highly Stereoselective Synthesis of Homoallylic Amines Based on Addition of Allyltrichlorosilanes to Benzoylhydrazones." ChemInform 33, no. 5 (2010): no. http://dx.doi.org/10.1002/chin.200205047.

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43

Kim, Sung Jun, and Doo Ok Jang. "ChemInform Abstract: Indium-Mediated Catalytic Enantioselective Allylation of N-Benzoylhydrazones Using a Protonated Chiral Amine." ChemInform 42, no. 3 (2010): no. http://dx.doi.org/10.1002/chin.201103068.

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44

Mirjana, S. Jankulovska, Dimova Vesna, and Jankulovska-Petkovska Milena. "Comparison and QSAR study of thermodynamic pKBH+ values of benzoylhydrazones determined by UV-Vis spectroscopy." Technologica Acta 15, no. 1 (2022): 53–60. https://doi.org/10.5281/zenodo.6922018.

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Thermodynamic dissociation constants of fifteen protonated aromatic hydrazones were determined by UV-Vis spectroscopic method, as one of the main methods for determination of p<em>K</em><sub>BH</sub><sup>+</sup> values of a weak acids and bases. The stoichiometric p<em>K</em><sub>BH</sub><sup>+</sup> values of investigated compounds were determined at three different ionic strengths (0.1, 0.25 and 0.5 mol/dm<sup>3</sup>) in acidic media (1 < pH < 7). The thermodynamic p<em>K</em><sub>BH</sub><sup>+</sup> values were evaluated graphically as an intercept with extrapolation to zero ionic s

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45

Jankulovska, Mirjana S., Ilinka Spirevska, and Vesna Dimova. "Investigation of Dissociation Process of Some 4-Methoxybenzaldehyde Benzoylhydrazones in Sodium Hydroxide Media by UV Spectroscopy." Letters in Organic Chemistry 15, no. 6 (2018): 515–22. http://dx.doi.org/10.2174/1570178615666180111143208.

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46

Kobayashi, Shū, and Ryoji Hirabayashi. "Highly Stereoselective Synthesis of Homoallylic Amines Based on Addition of Allyltrichlorosilanes to Benzoylhydrazones under Neutral Conditions." Journal of the American Chemical Society 121, no. 29 (1999): 6942–43. http://dx.doi.org/10.1021/ja990497g.

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47

Shchepin, V. V., N. F. Kirillov, and V. S. Melekhin. "Reformatsky reaction of methyl 1-bromocycloalkane-1-carboxylates with phenyl-and benzoylhydrazones derived from aromatic aldehydes." Russian Journal of Organic Chemistry 42, no. 10 (2006): 1486–89. http://dx.doi.org/10.1134/s1070428006100150.

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48

Kobayashi, Shū. "Scandium Triflate Catalyzed Allylation Reactions of Benzoylhydrazones with Tetraallyltin. An Efficient Catalytic Route to Homoallylic Amines." Synlett 1999, no. 1 (1999): 138–40. http://dx.doi.org/10.1055/s-1999-2566.

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49

Rao, A. R. Balavardhana, and Samudranil Pal. "Regioselective cyclometallation of 4-R-1-naphthaldehyde benzoylhydrazones: Palladium(II) complexes with CNO pincer like ligands." Journal of Organometallic Chemistry 731 (May 2013): 67–72. http://dx.doi.org/10.1016/j.jorganchem.2013.02.007.

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50

Nagaraju, Koppanathi, and Samudranil Pal. "Ortho-ruthenation of 1-naphthalenyl in 1-naphthaldehyde 4-R-benzoylhydrazones: Ruthenium(III) CNO pincer complexes." Journal of Organometallic Chemistry 745-746 (November 2013): 404–8. http://dx.doi.org/10.1016/j.jorganchem.2013.08.024.

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