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Journal articles on the topic 'Benzylidene derivative'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Kawsar, Sarkar MA, Abul KMS Kabir, MOhammad MR Bhuiyan, and Mohammad M. Manik. "Synthesis And Characterization Of Methyl 4, 6-O-Enzylidene- ?-D-Glucopyranoside Derivatives." Journal of the Bangladesh Chemical Society 25, no. 2 (2013): 101–9. http://dx.doi.org/10.3329/jbcs.v25i2.15045.

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Regioselective benzoylation of methyl 4,6-O-benzylidene-?-D-glucopyranoside (1) using direct acylation method furnished the methyl 4,6-O-benzylidene-2-O-(4-t-butylbenzoyl)- ?-D-glucopyranoside (2) in an excellent yield. In order to obtain newer products for antimicrobial screening studies, the 2-O-4-t-butylbenzoyl derivative was further transformed to a series of 3-O-acyl derivatives (2-12) containing a wide variety of functionalities in a single molecular framework. Journal of Bangladesh Chemical Society, Vol. 25(2), 101-109, 2012 DOI: http://dx.doi.org/10.3329/jbcs.v25i2.15045

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2

Singh Sethi, Navjot, Dn Prasad, Deepak Bhagwat, Anuradha Kumari, Madhu Sharma, and Sangeeta Kaundal. "SYNTHESIS, SPECTRAL, AND PHARMACOLOGICAL EVALUATION OF 3 AND 5 SUBSTITUTED 2,4-THIAZOLIDINEDIONE DERIVATIVES." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 363. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.12008.

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Background: 2,4-Thiazolidinedione derivatives was launched as antidiabetics in 90’s. Later the derivatives of 2,4-thiazolidinedione were banned due to hepatotoxicity. To the date, much research has been directed toward the synthesis and novel uses of 2,4-thiazolidinedione compounds.Aim: The aim of the present study is to synthesize a set of 3,5-disudstituted-2,4-thiazolidinediones as antimicrobial. These compounds were evaluated for their antimicrobial activity.Method: First, the 2,4-thiazolidinedione was substituted at the position of 3 using sodium hydroxide and ethanol and then substituted

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3

Marchalín, Štefan, and Josef Kuthan. "Synthesis of 3,5-dicyano-4-phenyl-2,6-bis(4-p-terphenylyl)-1,4-dihydropyridine. An attempt at extending the Hantzsch synthesis." Collection of Czechoslovak Chemical Communications 50, no. 9 (1985): 1962–70. http://dx.doi.org/10.1135/cccc19851962.

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The 3-oxopropanenitrile IIIc, prepared from 4-acetyl-p-terphenyl (IV) by the sequence IV → V → VI → IIIc, reacts with benzaldehyde and ammonium acetate in acetic acid to give the Hantzsch 1,4-dihydropyridine VIIc and the corresponding pyridine derivative VIIIc. The alternative cyclocondensation of benzylidene derivative IIc and 3-oxopropanenitrile IIIc in the presence of ammonium acetate exclusively gives the pyridine derivative VIIIc. Rate of thermal and oxidative aromatizations of the 1,4-dihydropyridine derivatives, VIIa → VIIc → VIIIa → VIIIc, decreases in the order VIIc > VIIb > VII

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4

Elbannany, Afaf A. A., and Laila I. Ibrahim. "Synthesis of 1-Benzoylpyrroline Derivative and Related Compounds." Zeitschrift für Naturforschung B 44, no. 2 (1989): 233–36. http://dx.doi.org/10.1515/znb-1989-0222.

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5

Maturi Someswara Rao, Tadiboina Bhaskara Rao, Cherukumalli Purna Koteswara Rao, and Nagaraj Maddur. "Synthesis And Characterization Of Novel Pyrimidine-4,5-Diamine As Anticancer Agent." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 4334–41. http://dx.doi.org/10.26452/ijrps.v11i3.2649.

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Unlike latent cells, cancer cells supply deoxyribonucleoside triphosphates to cells continuously and thereby, prop up the uncontrolled cancer growth. Pyrimidine has been concerned in the separation of leukemic cells, known as adenine bioisosteres, as well as its biological activities, especially its anticancer properties. In this context, a novel series of N5-(3-substituted benzylidene)-N4-phenyl pyrimidine-4,5-diamine [5A-5F] / N5-(2-substituted benzylidene)-N2,N2-dimethyl-N4-phenyl pyrimidine-2,4,5-triamine [5a-5f] were synthesized by using the starting ingredient formimidamide/4-(dimethylam

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6

Csuvik, Oszkár, Nikoletta Szemerédi, Gabriella Spengler, and István Szatmári. "Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents." International Journal of Molecular Sciences 23, no. 17 (2022): 9688. http://dx.doi.org/10.3390/ijms23179688.

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The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(1H,3H)-dione was optimised. Starting from 4-hydroxyquinolines (4HQs), aminomethylation was carried out via the modified Mannich reaction (mMr) applying formaldehyde and piperidine, but a second paraformaldehyde molecule was incorporated into the Mannich product. The reaction also afforded the formation of bisquinoline derivatives. A new 1H-azeto [1,2-a]quinoline derivative was synthesised in two different ways; namely starting from the aminomethylated product or from the ester-hydrolysed 4HQ. Wh

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7

Shabani-Nooshabadi, Mehdi, Mohsen Behpour, Faezeh Sadat Razavi, Masood Hamadanian, and Vajihe Nejadshafiee. "Study of N-benzylidene derivatives synthesized as corrosion inhibitors for copper in HCl solution." RSC Advances 5, no. 30 (2015): 23357–66. http://dx.doi.org/10.1039/c5ra00561b.

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Corrosion inhibition of the two N-benzylidene derivative compounds, as corrosion inhibitors for copper in HCl 6.0 M have been studied by electrochemical methods such as potentiodynamic polarization measurements and EIS.

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8

Patroni, JJ, RV Stick, BW Skelton та AH White. "The Selective Monobenzylidenation of Some Monosaccharides and Their Derivatives With α,α-Dimethoxytoluene". Australian Journal of Chemistry 41, № 1 (1988): 91. http://dx.doi.org/10.1071/ch9880091.

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The treatment of some monosaccharides and their derivatives with a,a-dimethoxytoluene and an acid catalyst in dimethylformamide at about 80° can lead to selective benzylidenation , e.g. methyl a-D- mannopyranoside gives mainly methyl 4,6-Obenzylidene-a-D-mannoside, together with two other minor monobenzylidene derivatives (2,3-) and two minor dibenzylidene derivatives (2,3:4,6-). The treatment of various other pyranoses and pyranosides is also described. As well, a 1H n.m.r . study of the acid transformation of some of the above α-D- mannosides is reported, together with a single-crystal X-ray

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9

Thabet, H. Kh, Mohd Imran, Mohd Imran, Saleh Alaql, and M. H. M. Helal. "Bis(2-cyanoacetamide) in Heterocyclic Synthesis: Synthesis of Some Bis[2-oxopyridine, 2-iminochromene, Chromeno[3,4-c]pyridine, Benzochromeno[3,4-c]pyridine] Derivatives." Oriental Journal Of Chemistry 40, no. 1 (2024): 65–73. http://dx.doi.org/10.13005/ojc/400108.

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N,N'-(methylenebis(1,4-phenylene))bis-(2-cyanoacetamide) was exploited as a precursor for synthesing some bis (benzylidene 5a-c, pyridines 7, 8, 10a,b, chromene 14, benzochromene 15) derivatives containing diphenyl-methylene spacer via the reaction with each of aromatic aldehydes, pentane-2,4-dione, acetaldehyde/ malononitrile, arylidene-malononitriles, ethyl cinnamates, 2-hydroxybenzaldehyde, and 2-hydroxy-1-naphthaldehyde). Bis(chromeno[3,4-c]pyridines 16&18) were synthesized via Michael's addition of malononitrile or ethyl cyanoacetate to bis(chromene) derivative. The newly prepared com

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10

Le, Zhang Gao, Kou Ni, Li Tao Guo, and Zong Bo Xie. "The Condensation Reaction of 4-Nitrobenzaldehyde and Rhodanine Catalyzed by Papain." Advanced Materials Research 830 (October 2013): 111–14. http://dx.doi.org/10.4028/www.scientific.net/amr.830.111.

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Papain was first used as the catalyst for the synthesis of 5-benzylidene rhodanine derivative through the condensation reaction of 4-nitrobenzaldehyde and rhodanine. The result showed that the yield could be up to 86% by optimizing the reaction conditions.

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11

Schaefer, Ted, and Craig S. Takeguchi. "Internal motion in benzylidene diacetate and its 2,6-dibromo derivative by DNMR and the J method." Canadian Journal of Chemistry 67, no. 6 (1989): 1022–26. http://dx.doi.org/10.1139/v89-155.

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The 1H nuclear magnetic resonance spectral parameters are reported for benzylidene diacetate in CS2 and acetone-d6 solutions. The long-range spin–spin coupling constant over six formal bonds, 6J, is used to derive apparent twofold barriers to rotation about the exocyclic C(1)—C bond in the two solutions. The conformation of lowest energy has the α. C—H bond in the benzene plane. The barrier is higher in CS2 than in acetone-d6 solution, in contrast to a molecule like benzyl chloride. In the 2,6-dibromo derivative, the free energy of activation for reorientation about the bond in question is 36

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12

Kassem, Asmaa F., Fatimah Alshehrei, Eman M. H. Abbas, and Thoraya A. Farghaly. "Synthesis of Azoloquinazolines and Substituted Benzothiazepine as Antimicrobial Agents." Mini-Reviews in Medicinal Chemistry 20, no. 5 (2020): 418–29. http://dx.doi.org/10.2174/1389557519666190603091101.

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Background & Objective:Quinazolines and their fused systems are noteworthy in pharmaceutical chemistry due to their wide range of biological activities.Methods:A direct and efficient approach for the synthesis of new series of fused quinazolines with triazole, thiazole, benzimidazole and tetrazole has been preceded via the reaction of quinazoline thione derivative with halogenated compounds or cyclocondensation of arylidene of quinazoline derivative with heterocyclic amines. Also, dibenzo[b,e][1,4]thiazepine derivatives was synthesized through the reaction of 2,6-bis-(2-chloro-benzylidene)

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13

Tatar, Esra, İlkay Küçükgüzel, Ş. Güniz Küçükgüze, et al. "Synthesis, Anti-Tuberculosis and Antiviral Activity of Novel 2-isonicotinoylhydrazono-5-arylidene-4-thiazolidinones." International Journal of Drug Design and Discovery 1, no. 1 (2010): 19–32. https://doi.org/10.37285/ijddd.1.1.3.

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This paper describes the synthesis and structural elucidation of some novel N'-[5-(substituted benzylidene)-3-alkyl-4-oxo-1,3-thiazolidin-2-ylidene]isonicotinohydrazides and evaluation of their chemotherapeutic potency. The most potent derivative demonstrated an IC90 value of 2.039 µg/ml and an IC50 value of 1.267 µg/ml against M. Tuberculosis H37Rv while one of our compounds inhibited cytopathicity of HIV-1 (IIIB) by 50% at 8.73 µg/ml and other two derivatives were found active against either thymidine kinase positive or deficient strains of varicella-zoster virus with IC50 values of 2.0 and

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14

Sališová, Marta, Ľubomír Šebo, Štefan Toma, and Eva Solčániová. "Study of the Reactivity of 2-Benzylidene[3]ferrocenophane-1,3-dione with Ethyl Acetoacetate and Some Other C-Nucleophiles." Collection of Czechoslovak Chemical Communications 58, no. 9 (1993): 2128–38. http://dx.doi.org/10.1135/cccc19932128.

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Michael addition of C-nucleophiles to 2-benzylidine[3]ferrocenophane-1,3-dione has been studied. In some cases, (ethyl acetoacetate, acetylacetone and malononitrile as the C-nucleophiles) the addition was followed by intramolecular cyclization leading to pyran derivatives. Addition of malononitrile gave the pyran derivative as a sole product. The Michael adducts of ethyl acetoacetate and acetylacetone can be converted to [7]ferrocenophane-1,7-dione derivatives by refluxing in benzene with triethylamine as catalyst. they also easily react with ammonia, under SiO2 catalysis, to give Hantzsch dih

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15

Möhrle, Hans, Jutta Mehrens, and Edith Tot. "Darstellung von 2,3,8-substituierten Perhydrooxazolo[3,2-a]pyridinen und die Kristallstruktur von (E)-3-(2-Fluorbenzyliden)-1-[1,2-bis(2-fluorphenyl)- 2-hydroxyethyl]-3,4,5,6-tetrahydropyridiniumchlorid." Zeitschrift für Naturforschung B 58, no. 6 (2003): 585–94. http://dx.doi.org/10.1515/znb-2003-0615.

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2-Fluorobenzaldehyde (1) and pipecolic acid (7) react in dimethyl sulfoxide with potassium carbonate to form benzylidene-oxaindolizidines 4. These diastereomers yield with acids uniform salts, so from 4 with hydrogen chloride results (E)-3-(2-fluorobenzylidene)-1-[1,2-bis(2-fluorophenyl)-2- hydroxyethyl]-3,4,5,6-tetrahydropyridinium chloride (6·Cl), elucidated by X-ray structural analysis. Treatment of 6·Cl with alkali hydroxide regenerates 4. Similarly proline (13), when treated with two equivalents of 1, gives rise to oxapyrrolizidines 14. From 14 in presence of 1 the perchlorate of the benz

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16

Chołuj, Artur, Wojciech Nogaś, Michał Patrzałek, et al. "Preparation of Ruthenium Olefin Metathesis Catalysts Immobilized on MOF, SBA-15, and 13X for Probing Heterogeneous Boomerang Effect." Catalysts 10, no. 4 (2020): 438. http://dx.doi.org/10.3390/catal10040438.

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Promoted by homogeneous Ru-benzylidene complexes, the olefin metathesis reaction is a powerful methodology for C-C double bonds formation that can find a number of applications in green chemical production. A set of heterogeneous olefin metathesis pre-catalysts composed of ammonium-tagged Ru-benzylidene complexes 4 (commercial FixCat™ catalyst) and 6 (in-house made) immobilized on solid supports such as 13X zeolite, metal-organic framework (MOF), and SBA-15 silica were obtained and tested in catalysis. These hybrid materials were doped with various amounts of ammonium-tagged styrene derivative

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17

Chaudhury, Aritra, Sajal K. Maity, and Rina Ghosh. "Efficient routes toward the synthesis of the D-rhamno-trisaccharide related to the A-band polysaccharide of Pseudomonas aeruginosa." Beilstein Journal of Organic Chemistry 10 (July 1, 2014): 1488–94. http://dx.doi.org/10.3762/bjoc.10.153.

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The present work describes efficient avenues for the synthesis of the trisaccharide repeating unit [α-D-Rhap-(1→3)-α-D-Rhap-(1→3)-α-D-Rhap] associated with the A-band polysaccharide of Pseudomonas aeruginosa. One of the key steps involved 6-O-deoxygenation of either partially or fully acylated 4,6-O-benzylidene-1-thiomannopyranoside by radical-mediated redox rearrangement in high yields and regioselectivity. The D-rhamno-thioglycosides so obtained allowed efficient access to the trisaccharide target via stepwise glycosylation as well as a one-pot glycosylation protocol. In a different approach

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18

Taha, Muhammad, M. Syukri Baharudin, Hamizah Mohd Zaki, Bohari M. Yamin, and Humera Naz. "Crystal structure of (E)-N′-benzylidene-2-methoxybenzohydrazide." Acta Crystallographica Section E Structure Reports Online 70, no. 9 (2014): o1071—o1072. http://dx.doi.org/10.1107/s1600536814019011.

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In the title benzoylhydrazide derivative, C15H14N2O2, the dihedral angle between the planes of the two phenyl rings is 12.56 (9)°. The azomethine double bond adopts anEconfiguration stabilized by an N—H...O hydrogen bond. In the crystal, the components are linked by C—H...O interactions to form chains along thebaxis.

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19

Hamama, Wafaa S., Mohamed A. Ismail, Hana’a A. Al-Saman, and Hanafi H. Zoorob. "Convenient Selective Synthesis of Substituted Pyrido[2,3-d]pyrimidones and Annulated Derivatives." Zeitschrift für Naturforschung B 62, no. 1 (2007): 104–10. http://dx.doi.org/10.1515/znb-2007-0115.

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The reaction of 6-aminouracil (1) with the appropriate α,β -unsaturated ketones, gave the corresponding pyrido[2,3-d]pyrimidin-2,4-diones 3, 6, 8 and 10, respectively. Treatment of 1 with salicylaldehyde, 6-carboethoxy-3,5-diphenyl-2-cyclohexenone (13) or 2,6- bis(phenylmethylidene)cyclohexanone (15) afforded the corresponding pyrimido[4,5-d]quinoline- 2,4-diones 12, 14 and 16, respectively. Furthermore, a pyrido[2,3-d]pyrimidine incorporating 3,2’- bis(quinoline) derivative 18 was synthesized. Annulation of pyrido[2,3-d]pyrimidine with pyrazole or imidazole moieties was achieved via reaction

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20

Baer, Hans H., Bruno Radatus та Jacques Defaye. "A new synthesis of 3-amino-3-deoxy-α-D-mannopyranosyl 3-amino-3-deoxy-α-D-mannopyranoside, a potential antituberculous agent". Canadian Journal of Chemistry 63, № 2 (1985): 440–44. http://dx.doi.org/10.1139/v85-072.

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A practical, four-step synthesis of the title compound starting from 2-O-benzyl-4,6-O-benzylidene-α-D-altropyranosyl 2-O-benzyl-4,6-O-benzylidene-α-D-altropyranoside is described. Trifluoromethylsulfonylation followed by azide displacement furnished the corresponding α-D-manno,α-D-manno 3,3′-diazido-3,3′-dideoxy derivative, and subsequent hydrolytic deacetalation, followed by catalytic transfer hydrogenolysis to simultaneously reduce the azido groups and cleave the benzyl ether groups, gave the title disaccharide in 30% overall yield. As preceding work had provided the blocked starting disacch

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21

Lee, C. K., M. Minami, S. Sakuda, T. Nihira, and Y. Yamada. "Stereospecific reduction of virginiamycin M1 as the virginiamycin resistance pathway in Streptomyces virginiae." Antimicrobial Agents and Chemotherapy 40, no. 3 (1996): 595–601. http://dx.doi.org/10.1128/aac.40.3.595.

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In a cell extract of Streptomyces virginiae, virginiamycin M1 was inactivated in the presence of NADPH, while virginiamycin S remained intact. The inactivated product of virginiamycin M1 was isolated, and structure analysis revealed that the inactivation involves reduction of a C-16 carbonyl group leading to the formation of 16-dihydrovirginiamycin M1. Acetonide and benzylidene acetal derivatives were synthesized from the two hydroxyl groups on C-14 and C-16, and the C-16 stereochemistry was determined by 13C nuclear magnetic resonance spectroscopy. Two methyl groups of the acetonide derivativ

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22

Du, Kangjia, Chengjie Yang, Zhongkun Zhou, et al. "A Novel Isaindigotone Derivative Displays Better Anti-Proliferation Activities and Induces Apoptosis in Gastric Cancer Cells." International Journal of Molecular Sciences 23, no. 14 (2022): 8028. http://dx.doi.org/10.3390/ijms23148028.

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Isaindigotone is an alkaloid containing a pyrrolo-[2,1-b]quinazoline moiety conjugated with a benzylidene group and isolated from the root of Isatis indigotca Fort. However, further anticancer activities of this alkaloid and its derivatives have not been fully explored. In this work, a novel isaindigotone derivative was synthesized and three different gastric cell lines and one human epithelial gastric cell line were used to study the anti-proliferation effects of the novel isaindigotone derivative BLG26. HGC27 cells and AGS cells were used to further explore the potential mechanisms. BLG26 ex

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23

Chen, Anji, Dan Wang, Lalith P. Samankumara, and Guijun Wang. "Synthesis of Sterically Congested Carbamates of Carbohydrates through Organic Base Catalysis." Synthesis 51, no. 15 (2019): 2897–908. http://dx.doi.org/10.1055/s-0037-1612425.

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4,6-O-Benzylidene acetal protected α-methoxy d-glucose and d-glucosamine are useful building blocks for the syntheses of carbohydrate derivatives and functional molecular assemblies. In this research, we have developed a general method for the preparation of C-3 carbamate derivatives of densely functionalized glucose and glucosamine with isocyanates using organic bases as catalysts. Without a suitable catalyst, the C-3 hydroxy group of the glucosamine derivative could not be converted into the corresponding carbamates when treated with isocyanates. Several organic bases were screened as the ca

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24

Sterns, M., JM Patrick, VA Patrick, and AH White. "Conformational Studies of Some Piperazine-2,5-Diones: Crystal Structures of Three Isomeric Forms of Methylanhydropicroroccellin (Derivative of a Lichen Diketopiperazine) and a Derivative Bromohydrin." Australian Journal of Chemistry 42, no. 3 (1989): 349. http://dx.doi.org/10.1071/ch9890349.

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Single-crystal X-ray structure determinations have been carried out on three isomeric forms of the lichen diketopiperazine metabolite methylanhydropicroroccellin , C21H22N2O3, and a related bromohydrin , C20Hl9BrN2O3; all are based on a 6-benzyl-3-benzylidene-1,4- dimethylpiperazine-2,5-dione but differ in the substituents on the α and β carbons at position 6, enabling comparison of the resulting variation in conformation.

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25

Chantrapromma, Suchada, Huey Chong Kwong, Patcharawadee Prachumrat, Thawanrat Kobkeatthawin, Tze Shyang Chia, and Ching Kheng Quah. "Crystal structure of (E)-N′-(3,4-dihydroxybenzylidene)-4-hydroxybenzohydrazide." Acta Crystallographica Section E Crystallographic Communications 75, no. 8 (2019): 1280–83. http://dx.doi.org/10.1107/s2056989019010442.

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In the title benzohydrazide derivative, C14H12N2O4, the azomethine C=N double bond has an E configuration. The hydrazide connecting bridge, (C=O)—(NH)—N=(CH), is nearly planar with C—C—N—N and C—N—N=C torsion angles of −177.33 (10) and −174.98 (12)°, respectively. The 4-hydroxyphenyl and 3,4-dihydroxyphenyl rings are slightly twisted, making a dihedral angle of 9.18 (6)°. In the crystal, molecules are connected by N—H...O and O—H...O hydrogen bonds into a three-dimensional network, while further consolidated via π–π interactions [centroid–centroid distances = 3.6480 (8) and 3.7607 (8) Å]. The

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26

Mosula, L. M., and K. S. Chudinovych. "Research of physicochemical, pharmacokinetic and druglikeness parameters of a series of 5-arylidene derivatives of 3-(benzo[d]thiazol-2-ylamino)-2-thioxothiazolidin-4-one)." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 3 (June 2025): 4–12. https://doi.org/10.32434/0321-4095-2025-160-3-4-12.

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The article presents in silico research of physicochemical, pharmacokinetic and druglikeness parameters of a series of 5-arylidene derivatives of 3-(benzo[d]thiazol-2-ylamino)-2-thioxothiazolidin-4-one. The web tool SwissADME was used for prediction of absorption, distribution, methabolism and excretion (ADME) of compounds. Based on the prediction results, it was determined that the introduction of an arylidene moiety into position 5 of the base compound with potentially high peroral availability negatively affects the passive absorption in the gastrointestinal tract. To further characterize t

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Mahernia, Shabnam, Niusha Sharifi, Malihe Hassanzadeh, et al. "Benzylidene Barbituric Acid Derivatives Shown Anticonvulsant Activity on Pentylenetetrazole-Induced Seizures in Mice: Involvement of Nitric Oxide Pathway." Pharmaceutical Sciences 24, no. 4 (2018): 250–56. http://dx.doi.org/10.15171/ps.2018.37.

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ABSTRACT Background: Barbituric acid derivatives have long been used as central nervous system (CNS) suppressants, such as sedatives, hypnotics and anticonvulsants. In addition, previous studies have implicated the involvement of nitric oxide (NO) in the anticonvulsive effects of barbiturates in CNS. Therefore, the purpose of this study was to figure out the effects of a novel class of barbituric acid derivatives on pentylenetetrazole (PTZ)-induced seizures in male mice. Methods: Thirteen synthesized barbituric acid derivatives (a-m) and phenobarbital were administered intraperitoneally (i.p.)

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Al-Abboodi1, Doaa Hashim, and Naeemah Al-lami. "NEW METHDOLOGY OF SYNTHESIS PYRAZOLO- THIAZOLO DERIVATIVES WITH STUDY ANTIMICROBAL ACTIVITIES." iraqi journal of market research and consumer protection 16, no. 1 (2024): 1–12. http://dx.doi.org/10.28936/jmracpc16.1.2024.(1).

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In this contribution, new derivatives of thiosemicarbazon, cyclic thiazolidinone, yilidine thiazolidinone, and parazolo-thiazole were synthesized, starting from the reaction of 2 -aminobenzothiazole with p-bromo phenacyl bromide to give the first step of 2(4-bromo phenyl) imidazole (2,1 -b) benzo thiazole (1). Compound (1) then was subjected under Viels Myer Haack to yield 3-carbaldehyde linking with imidazo-benzothiazol (2). Compound (2) condensed with thiosemicarbazide togivenewsynthesis of thiosemicarbazon derivative (3). Compound 4-Oxo-1,3-thiazolidine (4) was constituted from reacting com

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29

Yousuf, Sammer, Huma Bano, Munira Taj Muhammad, and Khalid Mohammed Khan. "Crystal structure of 2-[2-(benzyloxy)benzylidene]malononitrile." Acta Crystallographica Section E Crystallographic Communications 71, no. 8 (2015): o560—o561. http://dx.doi.org/10.1107/s2056989015012608.

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In the title benzylidenemalononitrile derivative, C17H12N2O, the dihedral angles between the central benzene ring and the Y-shaped C=C(CN)2group (r.m.s. deviation = 0.006 Å) and the terminal benzene ring are 12.72 (8) and 37.60 (11)°, respectively. The Car—O—Csp3—Cartorsion angle is −174.52 (13)° and the major twist between the aromatic rings occurs about the Csp3—Carbond. Weak aromatic π–π stacking [centroid–centroid separation = 3.7784 (13) Å; slippage = 1.21 Å] between inversion-related pairs of the central benzene rings is observed in the crystal.

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Mahmoud, M. R., A. A. Shalaby, T. A. Gad, and A. A. El-Khamry. "A facile synthesis and heteroannulation of pyrido[2,3-d]pyrimidine and related heterocyclic systems." Journal of Chemical Research 2009, no. 10 (2009): 612–15. http://dx.doi.org/10.3184/030823409x12523324765777.

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7-Amino-1,2,3,4-tetrahydro-4-oxo-2-thioxo-5-(3,4,5-trimethoxyphenyl)pyrido[2,3- d]pyrimidine (1) was prepared and reacted with methyl iodide and ethyl chloroacetate to give the S-alkylated products 2 and 3, respectively. The reaction of 1 or 3 with hydrazine hydrate yielded the same 2-hydrazino derivative 4. Treatment of 4 with 2,4-pentanedione, 2-acetylcyclohexanone and ethyl acetoacetate afforded the corresponding pyrazolylpyrido[2,3- d]pyrimidine derivatives (5–7), while phthalic anhydride gave the phthalazinyl compound 8. Ethoxymethylenemalononitrile with the hydrazine 4 formed the fused 1

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31

WATANABE, Koju, Fumihiko KIMURA, and Masayuki SHINMEI. "Effect of Benzylidene Derivative (Novel Antirheumatic Agent) on Chondrocyte Metabolism." Journal of Pharmacobio-Dynamics 15, no. 5 (1992): 239–46. http://dx.doi.org/10.1248/bpb1978.15.239.

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32

Tsunekawa, Tetsuya, Tetsuya Gotoh, and Masao Iwamoto. "New organic non-linear optical crystals of benzylidene-aniline derivative." Chemical Physics Letters 166, no. 4 (1990): 353–57. http://dx.doi.org/10.1016/0009-2614(90)85042-b.

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33

Salian, Akshatha R., Sabine Foro, and B. Thimme Gowda. "Crystal structure and Hirshfeld surface analysis of (E)-N′-benzylidene-4-chlorobenzenesulfonohydrazide and of its (E)-4-chloro-N′-(ortho- and para-methylbenzylidene)benzenesulfonohydrazide derivatives." Acta Crystallographica Section E Crystallographic Communications 74, no. 11 (2018): 1613–18. http://dx.doi.org/10.1107/s2056989018014500.

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(E)-N′-Benzylidene-4-chlorobenzenesulfonohydrazide, C13H11ClN2O2S, (I), and its ortho- and para-methylsubstituted derivatives, C14H13ClN2O2S, namely (E)-4-chloro-N′-(2-methylbenzylidene)benzenesulfonohydrazide, (II), and (E)-4-chloro-N′-(4-methylbenzylidene)benzenesulfonohydrazide, (III), have been synthesized, characterized spectroscopically and their crystal structures determined to investigate the effect of the substitution site of the benzylidene group on the structural and supramolecular features in these compounds. Compounds (I) and (II) are isotypic while compound (III) is different. Al

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34

Gubaidullin, Rinat, Darya Nedopekina, Regina Evstifeeva, and Yurij Prochukhan. "Effective Synthesis of a Novel Tetrahydrofuran Containing Triterpenoid: 5′(Z)-Benzylidene-tetrahydrofurano[3,2-b]lup-20(29)-en-28-oate." Molbank 2019, no. 1 (2018): M1042. http://dx.doi.org/10.3390/m1042.

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The title compound 5′(Z)-benzylidene-tetrahydrofurano[3,2-b]lup-20(29)-en-28-oate was synthesized with high chemo-, regio-, and stereoselectivity by 5-exo-dig cycloisomerization of methyl 2α-phenylpropynyl-3-oxolup-20(29)-en-28-oate with use of KN(SiMe3)2-DME. The novel betulinic acid derivative was fully characterized by conventional analytical methods and all proton and carbon signals have been completely assigned by 2D-NMR experiments.

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35

González, M. Lozano, M. E. Sánchez-Vergara, J. R. Álvarez-Bada, M. I. Chávez-Uribe, Rubén A. Toscano, and C. Álvarez-Toledano. "Synthesis and optical properties of iron(iii) complexes of 2-benzylidene-1-indanone derivative thin films." J. Mater. Chem. C 2, no. 28 (2014): 5607–14. http://dx.doi.org/10.1039/c4tc00599f.

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36

Tolba, Mahmoud S., Mostafa Sayed, Shaban A. A. Abdel-Raheem, Taher A. Gaber, Adel M. Kamal El-Dean, and Mostafa Ahmed. "Synthesis and spectral characterization of some new thiazolopyrimidine derivatives." Current Chemistry Letters 10, no. 4 (2021): 471–78. http://dx.doi.org/10.5267/j.ccl.2021.4.004.

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Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry due to their pharmaceutical importance. Herein, we report the synthesis of some new heterocyclic compounds containing thiazolopyrimidine starting from compound (1) which was previously prepared in literature. The starting compound was allowed to react with different alkylating agents such as chloroacetone, chloroacetyl chloride, and phenacyl bromide to afford derivatives (2-4). Compound (5), benzylidene derivative, was obtained by the reaction of compound (2) with benzaldehyde while amino-dicarbonit

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37

Coelho, Tatiane S., Jessica B. Cantos, Marcelle L. F. Bispo, et al. "In vitro anti-mycobacterial activity of (E)-N´-(monosubstituted-benzylidene) isonicotinohydrazide derivatives against isoniazid-resistant strains." Infectious Disease Reports 4, no. 1 (2012): 13. http://dx.doi.org/10.4081/idr.2012.e13.

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A series of twenty-three <em>N-acylhydrazones</em> derived from isoniazid (INH 1-23) have been evaluated for their <em>in vitro</em> antibacterial activity against INH- susceptible strain of <em>M. tuberculosis</em> (RG500) and three INH-resistant clinical isolates (RG102, RG103 and RG113). In general, derivatives 4, 14, 15 and 16 (MIC=1.92, 1.96, 1.96 and 1.86 mM, respectively) showed relevant activities against RG500 strain, while the derivative 13 (MIC=0.98 mM) was more active than INH (MIC=1.14 mM). However, these derivatives were inactive against RGH102

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38

Glisin, Djordje, Olga Jovanovic, Gordana Stojanovic та ін. "Synthesis of methyl 3,4-anhydro-6-bromo-2-o-tert-butyldimethylsilyl-6-deoxy-α-d-allopyranoside from α-d-glucose". Journal of the Serbian Chemical Society, № 00 (2024): 49. http://dx.doi.org/10.2298/jsc230831049g.

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Some of simple carbohydrates and their derivatives are used clinically for the treatment of various diseases. Epoxide derivatives, which can be obtained by the intramolecular elimination of water from two vicinal hydroxyl groups, are stable, but sufficiently reactive compounds very often used as intermediaries in various syntheses. Synthesis of epoxide derivative, methyl 3,4-anhydro-6- bromo-2-O-tert-butyldimethylsilyl-6-deoxy-?-D-allopyranoside from ?-D-glucose was achieved in high yields in the minimal number of synthetic steps. Anhydrous glucose was used as a starting material which was tra

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39

Jubeen, Farhat, Ishrat Jabeen, Usman Aftab, et al. "Synthesis, Characterization, Theoretical and Experimental Anticancer Evaluation of Novel Cocrystals of 5-Fluorouracil and Schiff Bases against SW480 Colorectal Carcinoma." Pharmaceutics 15, no. 7 (2023): 1929. http://dx.doi.org/10.3390/pharmaceutics15071929.

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The chemotherapeutic agent known as 5-fluorouracil (5-FU) is an artificial fluoropyrimidine antimetabolite that has been widely used for its antineoplastic properties. Cocrystals of 5-fluorouracil (5-FU) with five different Schiff bases (benzylidene-urea (BU), benzylidene-aniline (BA), salicylidene-aniline (SA), salicylidene-phenylhydrazine (SPH), and para-hydroxy benzylideneaniline (HBA)) are reported in this study. The newly synthesized cocrystals were analyzed by FTIR and PXRD. In this study, we investigated the antitumor efficacy of 5-FU derivatives in SW480 colon cancer cells via MTT assa

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Gao, Hong-Ling, Xiao-Pu Zhou, Yan-Xia Bi та ін. "A Dy4 single-molecule magnet and its Gd(iii), Tb(iii), Ho(iii), and Er(iii) analogues encapsulated by an 8-hydroxyquinoline Schiff base derivative and β-diketonate coligand". Dalton Transactions 46, № 14 (2017): 4669–77. http://dx.doi.org/10.1039/c7dt00118e.

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41

Shukla, Karuna S., Shailendra Pandey, and Pooja Chawla. "Synthesis of Some 5-(substituted benzylidene-2, 4-dioxothiazolidin-3-yl) benzoic Acid Derivatives by Conventional and Microwave-assisted Methods and Evaluation of their Potential as Antimicrobial Agents." Anti-Infective Agents 17, no. 2 (2019): 115–29. http://dx.doi.org/10.2174/2211352516666181024151213.

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<P>Background: Multiple antibiotic resistant bacteria represent a challenge in the treatment of infections. It is imperative, therefore, that new substances with antimicrobial properties should be searched to fight these microorganisms. Objective: A series of 5-benzylidene-2, 4-dioxothiazolidin-3-yl benzoic acid derivatives were synthesized and evaluated their antimicrobial potential. The compounds were synthesized by both conventional and microwave synthesizers. Methods: In this study, a series of 5-benzylidene-2, 4-dioxothiazolidin-3-yl benzoic acid derivatives were synthesized by Knoe

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42

Kefurt, Karel, Zdeňka Kefurtová, and Jiří Jarý. "6-Amino-6-deoxyhexonolactams." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1795–805. http://dx.doi.org/10.1135/cccc19881795.

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6-Azido-6-deoxy-D-mannose (III), prepared from methyl 4,6-O-benzylidene-α-D-mannopyranoside, 6-azido-6-deoxy-D-talose (XI), prepared from methyl 6-azido-2,3-O-isopropylidene-α-D-mannopyranoside (VII) via 4-keto derivative VIII, and 6-azido-6-deoxy-L-idose (XVIII), obtained from 5,6-anhydro-1,2-O-isopropylidene-β-L-idofuranose, on oxidation with bromine and subsequent reduction of the azido group afforded the corresponding 6-amino-6-deoxyhexonolactams V, XV, and XXI. 6-Amino-6-deoxyhexonic acids IV and XIV were also prepared.

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43

Garcia-Ramos, Yesica, Caroline Proulx, and William D. Lubell. "Synthesis of hydrazine and azapeptide derivatives by alkylation of carbazates and semicarbazones." Canadian Journal of Chemistry 90, no. 11 (2012): 985–93. http://dx.doi.org/10.1139/v2012-070.

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Hydrazine and azapeptide analogs were synthesized effectively by alkylation of alkylidene carbazates and semicarbazones. In comparisons of benzylidene, benzhydrylidene, and fluorenylidene tert-butyl carbazates in alkylations using bases of different pKb character, superior conversion was obtained using the fluorenone derivative. Mild alkylation conditions were found employing Et4NOH as base and used to convert fluorenylidene tert-butyl carbazate into 13 different protected hydrazines. Moreover, racemization was avoided during alkylation of fluorenylidene semicarbazide in the synthesis of aza-p

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44

Schirmer, Marie-Luis, Anke Spannenberg, and Thomas Werner. "Highly functionalized alkenes produced from base-free organocatalytic Wittig reactions: (E)-3-benzylidenepyrrolidine-2,5-dione, (E)-3-benzylidene-1-methylpyrrolidine-2,5-dione and (E)-3-benzylidene-1-tert-butylpyrrolidine-2,5-dione." Acta Crystallographica Section C Structural Chemistry 72, no. 6 (2016): 504–8. http://dx.doi.org/10.1107/s2053229616008159.

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The Wittig reaction is a fundamental transformation for the preparation of alkenes from carbonyl compounds and phosphonium ylides. The ylides are prepared prior to the olefination step from the respective phosphonium salts by deprotonation utilizing strong bases. A first free-base catalytic Wittig reaction for the preparation of highly functionalized alkenes was based on tributylphosphane as the catalyst. Subsequently we developed a system employing a phospholene oxide as a pre-catalyst and trimethoxysilane as reducing agent which operates under milder conditions. The title compounds, (E)-3-be

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45

Kerru, Nagaraju, Surya Narayana Maddila, Suresh Maddila, Sreedhar Sobhanapuram, and Sreekantha B. Jonnalagadda. "Synthesis and antimicrobial activity of novel thienopyrimidine linked rhodanine derivatives." Canadian Journal of Chemistry 97, no. 2 (2019): 94–99. http://dx.doi.org/10.1139/cjc-2018-0220.

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This work presents the preparation of a new series of N-(substituted phenyl)-2-(4-oxo-5-(4-(thieno[2,3-d]-pyrimidin-4-yloxy)benzylidene)-2-thioxothiazolidin-3-yl)acetamide derivatives (8a–8l). A condensation reaction of thienopyrimidin-2-thioxothiazolidin-4-one derivative (5) with various 2-chloro-N-phenylacetamides (7a–7l) was employed to afford the new thienopyrimidine tagged rhodanine derivatives under acetone solvent in the presence of potassium carbonate (K2CO3). All of the novel target molecules were characterized by IR, 1H NMR, 13C NMR, and LC–MS spectral analyses and were screened for

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46

Vastag, Gy, E. Szöcs, A. Shaban, and E. Kálmán. "New inhibitors for copper corrosion." Pure and Applied Chemistry 73, no. 12 (2001): 1861–69. http://dx.doi.org/10.1351/pac200173121861.

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The study of the effectiveness of several potential copper corrosion inhibitors in acidic media was studied. The investigated thiazole derivative functional groups contain heterocyclic atoms such as nitrogen, sulfur, and oxygen. Thiazole derivatives, 5-benzylidene-2,4-dioxotetrahydro-1,3-thiazole (BDT) 5-(4¢-isopropylbenzylidene)-2,4-dioxotetrahydro-1,3-thiazole (IPBDT), 5-(3¢-thenylidene)-2,4-dioxotetrahydro-1,3-thiazole (TDT), and 5-(3¢,4¢-dimetoxybenzylidene)-2,4-dioxotetrahydro-1,3-thiazole (MBDT) were tested for copper corrosion inhibition properties. The electrolyte solution was 0.1 M Na

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47

Araújo, Gleycyelly Rodrigues, Palloma Christine Queiroga Gomes da Costa, Paula Lima Nogueira, et al. "In Silico and In Vitro Evaluation of the Antifungal Activity of a New Chromone Derivative against Candida spp." BioTech 13, no. 2 (2024): 16. http://dx.doi.org/10.3390/biotech13020016.

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Candida species are frequently implicated in the development of both superficial and invasive fungal infections, which can impact vital organs. In the quest for novel strategies to combat fungal infections, there has been growing interest in exploring synthetic and semi-synthetic products, particularly chromone derivatives, renowned for their antimicrobial properties. In the analysis of the antifungal activity of the compound (E)-benzylidene-chroman-4-one against Candida, in silico and laboratory tests were performed to predict possible mechanisms of action pathways, and in vitro tests were pe

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48

Kuszmann, János, and Benjámin Podányi. "Acetolysis of a 2,4-O-benzylidene-l-ribo-hex-5-enitol derivative." Carbohydrate Research 257, no. 2 (1994): 217–26. http://dx.doi.org/10.1016/0008-6215(94)80036-7.

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49

Bachinsky, S. Yu, N. O. Burenkova, S. A. Andronati, and Yu V. Ishkov. "SYNTHESIS AND PROPERTIES OF NEW 1-HYDRAZINOCARBONYLMETHYL-7-BROMO-5-PHENYL-3-ARYLYDENE-1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2-ONES." Odesa National University Herald. Chemistry 28, no. 2(85) (2023): 43–51. http://dx.doi.org/10.18524/2304-0947.2023.2(85).286601.

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It is known that 1,4-benzodiazepines have neurotropic properties. Previously, we synthesized a series of 3-arylidene-1,2-dihydro-3H-1,4-benzdiazepin-2-ones 11-18 and showed that they exhibit significant analgesic activity. They also show significant affinity for central benzodiazepine receptors and TSPO receptors CNS. With this in mind, we have previously modified the series of 3-arylidene-1,2-dihydro-3H-1,4-benzodiazepin-2-ones by alkylation of 3-arylidene-1,2-dihydro-3H-1,4-benzodiazepin-2-ones with monobromoacetic acid methyl ester to the first position of the 1,4-diazepine ring to obtain 1

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More, S. A., N. S. Sakle, and S. N. Mokale. "DUAL TARGETING OF VEGFR-2 AND C-MET KINASES VIA THE DESIGN AND SYNTHESIS OF SUBSTITUTED BENZYLIDENE-6-(5-CHLOROPYRIMIDIN-2-YL)-9H-PURINE2,6-DIAMINE DERIVATIVES AS ANGIOGENESIS INHIBITORS." RASAYAN Journal of Chemistry 15, no. 04 (2022): 2964–68. http://dx.doi.org/10.31788/rjc.2022.1547094.

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We have designed and synthesized a unique library of benzylidene-6-(5-chloropyrimidin-2-yl)-9H-purine-2,6- diamine derivatives as angiogenesis inhibitors. The designed scaffolds were subjected to docking and ADME prediction studies so as to guage the particular interaction. Further anti-proliferative activity was allotted by employing the SRB method as a target for colorectal cancer on HT-29 and COLO-205 cell lines. The SM-6 derivative showed good anticancer activity and was subjected to in-vitro enzyme inhibition activity using a flow cytometer to test the enzyme inhibition potential. It also

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