Academic literature on the topic 'Benzyls derivatives'

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Dissertations / Theses on the topic "Benzyls derivatives"

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Jaafar, Amani. "Synthèse, Caractérisation et Activité biologique des complexes à base de thiosemicarbazone." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0011/document.

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Le thiosemicarbazide et le 4-méthylthiosemicarbazide réagissent par condensation avec des dérivés benzaldéhyde pour donner des produits de type thiosemicarbazone pouvant jouer le rôle de ligands.Ces derniers peuvent conduire en milieu éthanolique à la formation de divers complexes en réagissant avec des sels métalliques comme les chlorures et/ou bromures de cuivre(II), de nickel(II), de zinc(II), de cobalt(II) et de cadmium(II). La structure de ces ligands et de leurs complexes a été déterminée par spectroscopie infrarouge, par des analyses élémentaires et par cristallographie. Les ligands se
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Lenihan, Brian David. "Generation of o-quinodimethanes from derivatives of trimethyl (o- ((p-tolylsulfonyl)methyl)benzyl)silane : a synthetic equivalent for the o-quinodimethant-[alpha], [alpha]- /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487780393267272.

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Abou-Elkhair, Reham A. I. "Synthesis of anthraquinone derivatives and their conjugates with 2'-deoxynucleosides as new probes for electron transfer studies in DNA." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-07182008-154942/.

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Thesis (Ph. D.)--Georgia State University, 2008.<br>Title from file title page. Thomas L. Netzel, Dabney W. Dixon, committee co-chairs; David Boykin, Jerry Smith, committee members. Electronic text (250 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed Nov. 20, 2008. Includes bibliographical references.
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Pham, Van Tuyet. "The synthesis and reactions of chiral 1,3,2-oxazaphospholane derivations : kinetic and mechanistic studies of polyether omega-phase catalyzed reactions of potassium cyanide with benzyl bromide in non-polar, aprotic solvent toluene." Diss., Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/27416.

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Bresciani, Stefano. "Stereospecific dehydroxyfluorination and the synthesis of trifluoro D-hexose sugar analogues." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/1878.

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This thesis describes stereospecific fluorination reactions, and addresses the synthesis of fluorosugars. In Chapter 1, the influence of fluorine on the physical properties of organic molecules, as well as its stereoelectronic effects, are introduced. Furthermore, an overview of nucleophilic and electrophilic fluorination reactions is given. Chapter 2 describes the dehydroxyfluorination of allylic alcohol diastereoisomers 155a and 155b, which can proceed either by direct or allylic fluorination. The regio- and stereo- selectivities were also assessed. Chapter 3 outlines the synthesis of the no
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Jůza, Radomír. "Příprava benzoylovaných derivátů cyklodextrinů." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-365317.

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This master thesis deals with the preparation of the cyclodextrin (CD) derivatives that are suitable for complexation of the electron-rich aromatic compounds such as helicenes. The basic skeleton of native CD was perbenzoylated in all positions 2, 3 and 6 in the first place. Then the nucleophilic attack of carboxylates of benzoic acids with electron- withdrawing groups (NO2) or electron-donating group (NH2) to per(6-deoxy-6-iodo)-CD derivatives were used to prepare the perbenzoylated CD derivatives in the postition 6. Binding constant was determined for the prepared benzoylated derivatives of
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Chang, Ren-Chieh, and 張仁傑. "Design and Synthesis of Benzyl Caffeate Derivatives as JAK2 Inhibitors." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/96461041056529506594.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>99<br>JAK (Janus kinase) is a cytokine-induced kinase that activates STAT (Signal Transducer and Activator of Transcription) on many kinds of physiological effect such as cell proliferation, differentiation, and angiogenesis. Literature has been shown that over-activated JAK2/STAT3 pathway leads to highly transcription of oncogenes in various cancers, including solid tumor (e.g., liver, breast) as well as hematological malignancies. A series of JAK2 inhibitors have been developed and some of the inhibitors have been tested in clinical trial. Therefore, development of
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Lo, mei ting, and 羅美婷. "Apoptosis induced by 1-benzyl carbazole-4-carboxaldehyde derivatives in human leukemia cell lines." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/90007866802222515218.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>89<br>Abstract Synthesized 1-benzyl carbazole-4-carboxaldehyde derivatives ( LCY ) examined for their growth inhibition effects in human leukemia cell lines. HL60, U937, and K562 cells were treated with these compounds for 24 hours and their proliferation was determined by the propidium iodide DNA staining method. A dose-dependent decrease in the cell proliferation rate was observed for all compounds. LCY-12 had the highest growth inhibitory, and its IC50 were 2.58, 0.77, and 19.49 μM for HL60, U937, and K562 cells, respectively. DAPI-stained cells revea
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Ko, Chinyi, and 柯勤益. "Synthesis of Benzoyl Andrographolide Derivatives as Potential Dual-function Anti-influenza Agents." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/50693715295643741209.

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碩士<br>國防醫學院<br>藥學研究所<br>99<br>To conquer the drug resistance of influenza virus and improve the oral bioavalibility of current used neuraminidase inhibitors (NAIs), novel aromatic neuraminidase inhibitors (ANIs) based on ‘airplane model’ become an attractive issue in drug discovery. Besides, andrographolide (Andro), the active component of A. paniculata has effective neuraminidase inhibitory activity in vitro (EC50 = 35.69 μM, against H1N1) and one of its derivatives, 14-α-lipoyl andrographolide (AL-1), was reported that it has potent hemagglutinin inhibitory activity. Furthermore, the goal o
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Huang, Chun-Lung, and 黃俊龍. "Synthesis and biological activity of 1-benzyl-4-hydroxy-3-phenylquinolin-2(1H)-one derivatives." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/37426286995940238871.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>The dissertation is based on the structure of 4-hydroxy- quinolin-2-(1H)-ones. In order to synthesize a series of derivatives of 1-benzyl-4-hydroxy-3-phenylquinolin-2(1H)-one (26a-g, 27a-g, 28, 29), Using the Bheemashankar′s solution-phase combinatorial synthetic method. The starting material is methyl anthranilate (16) that is condensated with 4-substituted-benzaldehydes 17a-h to obtain the 19a-h. On the other hand, 4-cyanophenyl acetic acids 20a-d were acylated with thionyl chloride to afford acid chlorides 21a-d. Then, 21a-d and 19a-h are combined by Scho
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