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Dissertations / Theses on the topic 'Benzyls derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Jaafar, Amani. "Synthèse, Caractérisation et Activité biologique des complexes à base de thiosemicarbazone." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0011/document.

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Le thiosemicarbazide et le 4-méthylthiosemicarbazide réagissent par condensation avec des dérivés benzaldéhyde pour donner des produits de type thiosemicarbazone pouvant jouer le rôle de ligands.Ces derniers peuvent conduire en milieu éthanolique à la formation de divers complexes en réagissant avec des sels métalliques comme les chlorures et/ou bromures de cuivre(II), de nickel(II), de zinc(II), de cobalt(II) et de cadmium(II). La structure de ces ligands et de leurs complexes a été déterminée par spectroscopie infrarouge, par des analyses élémentaires et par cristallographie. Les ligands se

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2

Lenihan, Brian David. "Generation of o-quinodimethanes from derivatives of trimethyl (o- ((p-tolylsulfonyl)methyl)benzyl)silane : a synthetic equivalent for the o-quinodimethant-[alpha], [alpha]- /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487780393267272.

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3

Abou-Elkhair, Reham A. I. "Synthesis of anthraquinone derivatives and their conjugates with 2'-deoxynucleosides as new probes for electron transfer studies in DNA." unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-07182008-154942/.

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Thesis (Ph. D.)--Georgia State University, 2008.<br>Title from file title page. Thomas L. Netzel, Dabney W. Dixon, committee co-chairs; David Boykin, Jerry Smith, committee members. Electronic text (250 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed Nov. 20, 2008. Includes bibliographical references.

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4

Pham, Van Tuyet. "The synthesis and reactions of chiral 1,3,2-oxazaphospholane derivations : kinetic and mechanistic studies of polyether omega-phase catalyzed reactions of potassium cyanide with benzyl bromide in non-polar, aprotic solvent toluene." Diss., Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/27416.

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5

Bresciani, Stefano. "Stereospecific dehydroxyfluorination and the synthesis of trifluoro D-hexose sugar analogues." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/1878.

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This thesis describes stereospecific fluorination reactions, and addresses the synthesis of fluorosugars. In Chapter 1, the influence of fluorine on the physical properties of organic molecules, as well as its stereoelectronic effects, are introduced. Furthermore, an overview of nucleophilic and electrophilic fluorination reactions is given. Chapter 2 describes the dehydroxyfluorination of allylic alcohol diastereoisomers 155a and 155b, which can proceed either by direct or allylic fluorination. The regio- and stereo- selectivities were also assessed. Chapter 3 outlines the synthesis of the no

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6

Jůza, Radomír. "Příprava benzoylovaných derivátů cyklodextrinů." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-365317.

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This master thesis deals with the preparation of the cyclodextrin (CD) derivatives that are suitable for complexation of the electron-rich aromatic compounds such as helicenes. The basic skeleton of native CD was perbenzoylated in all positions 2, 3 and 6 in the first place. Then the nucleophilic attack of carboxylates of benzoic acids with electron- withdrawing groups (NO2) or electron-donating group (NH2) to per(6-deoxy-6-iodo)-CD derivatives were used to prepare the perbenzoylated CD derivatives in the postition 6. Binding constant was determined for the prepared benzoylated derivatives of

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7

Chang, Ren-Chieh, and 張仁傑. "Design and Synthesis of Benzyl Caffeate Derivatives as JAK2 Inhibitors." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/96461041056529506594.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>99<br>JAK (Janus kinase) is a cytokine-induced kinase that activates STAT (Signal Transducer and Activator of Transcription) on many kinds of physiological effect such as cell proliferation, differentiation, and angiogenesis. Literature has been shown that over-activated JAK2/STAT3 pathway leads to highly transcription of oncogenes in various cancers, including solid tumor (e.g., liver, breast) as well as hematological malignancies. A series of JAK2 inhibitors have been developed and some of the inhibitors have been tested in clinical trial. Therefore, development of

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8

Lo, mei ting, and 羅美婷. "Apoptosis induced by 1-benzyl carbazole-4-carboxaldehyde derivatives in human leukemia cell lines." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/90007866802222515218.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>89<br>Abstract Synthesized 1-benzyl carbazole-4-carboxaldehyde derivatives ( LCY ) examined for their growth inhibition effects in human leukemia cell lines. HL60, U937, and K562 cells were treated with these compounds for 24 hours and their proliferation was determined by the propidium iodide DNA staining method. A dose-dependent decrease in the cell proliferation rate was observed for all compounds. LCY-12 had the highest growth inhibitory, and its IC50 were 2.58, 0.77, and 19.49 μM for HL60, U937, and K562 cells, respectively. DAPI-stained cells revea

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9

Ko, Chinyi, and 柯勤益. "Synthesis of Benzoyl Andrographolide Derivatives as Potential Dual-function Anti-influenza Agents." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/50693715295643741209.

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碩士<br>國防醫學院<br>藥學研究所<br>99<br>To conquer the drug resistance of influenza virus and improve the oral bioavalibility of current used neuraminidase inhibitors (NAIs), novel aromatic neuraminidase inhibitors (ANIs) based on ‘airplane model’ become an attractive issue in drug discovery. Besides, andrographolide (Andro), the active component of A. paniculata has effective neuraminidase inhibitory activity in vitro (EC50 = 35.69 μM, against H1N1) and one of its derivatives, 14-α-lipoyl andrographolide (AL-1), was reported that it has potent hemagglutinin inhibitory activity. Furthermore, the goal o

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10

Huang, Chun-Lung, and 黃俊龍. "Synthesis and biological activity of 1-benzyl-4-hydroxy-3-phenylquinolin-2(1H)-one derivatives." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/37426286995940238871.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>The dissertation is based on the structure of 4-hydroxy- quinolin-2-(1H)-ones. In order to synthesize a series of derivatives of 1-benzyl-4-hydroxy-3-phenylquinolin-2(1H)-one (26a-g, 27a-g, 28, 29), Using the Bheemashankar′s solution-phase combinatorial synthetic method. The starting material is methyl anthranilate (16) that is condensated with 4-substituted-benzaldehydes 17a-h to obtain the 19a-h. On the other hand, 4-cyanophenyl acetic acids 20a-d were acylated with thionyl chloride to afford acid chlorides 21a-d. Then, 21a-d and 19a-h are combined by Scho

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11

Yang, Ju-Ying, and 楊如盈. "Transformation of D-(-)-quinic acid into 3,4,6-trihydroxyazepanes and their N-benzyl derivatives for potential glycosidase inhibitors." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/00627216705643635736.

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碩士<br>淡江大學<br>化學學系碩士班<br>93<br>The naturally occurring five- and six-membered azasugars are considered as glycosidase inhibitors. Most recently, the seven-membered azasugars(poly-hydroxyazepanes) were reported to have potential in treatment of diabetes, cancers and AIDS. These heterocycles are more flexible in conformation than the corresponding six- and five-membered counterparts and may bind in the minor groove of DNA. Little attention has been given to trihydroxyazepanes. We wish to describe herein a new approach to the synthesis of diastereomeric azasugars (3,4,6-trihydroxyazepanes) in

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12

Tsai, Shang-Cheng, and 蔡尚宬. "I. Synthesis of D-amino acid derivatives from camphorII . Preparation of 1-benzyl indenones from 1-indanone." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/79a39r.

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碩士<br>國立暨南國際大學<br>應用化學系<br>107<br>I、Most of the natural amino acids are mainly L-amino acids, and the D-amino acids are the enantiomers of L-amino acids, which can be incorporated into the peptides to adjust their biological activities. In this laboratory, we used the camphor as the starting material for the Witting reaction, the oxidation reaction, the ring expansion reaction and the reduction reaction to obtain the organic catalyst based on camphor. On this basis, we used palladium metal as the catalyst after the hydrogenation expansion product. The hydrogenated product is obtained, and then

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13

Chen, Hua-Sin, and 陳華鑫. "Synthesis and biological activities of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivative." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/47453222969722384672.

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博士<br>中國醫藥大學<br>藥物化學研究所<br>96<br>In the previous study, ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) was identified as the first selective non-peptide protease-activated receptor 4 (PAR4) antagonist. In order to develop noel PAR4 antagonist, YD-3 was selected as lead compound. Two series of N1-substituted arylmethyl-3-(4-ethoxycarbonylphenyl)indazole derivatives (I) and N2-substituted arylmethyl-3-(4-ethoxycarbonylphenyl)indazole derivatives (II) were synthesized. The key intermediate, ethyl 4-(1H-indazol-3-yl)- benzoate (8) was prepared according to the know method. Then, compound 8

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14

Yu, Michael Seungju. "Smectic ordering of rod-like polymers owing to monodispersity of chain length: Synthesis and characterization of benzyl and (4-hexadecyloxy)benzyl esters of monodisperse derivatives of poly(alpha,L-glutamate)." 1998. https://scholarworks.umass.edu/dissertations/AAI9909234.

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Two types of monodisperse rod-like polymers, poly($\gamma$-benzyl $\alpha$,L-glutamate) (PBLG) and poly($\gamma$-4-(hexadecyloxy)benzyl $\alpha$,L-glutamate) with backbone sequences of have been prepared by chemical modification of monodisperse poly($\alpha$,L-glutamic acid) (PLGA) that was synthesized by recombinant DNA biosynthesis techniques. The monodisperse PLGA () was produced in Escherichia coli as a fusion to mouse dihydrofolate reductase and purified to homogeneity by metal affinity chromatography, CNBr digestion and ion-exchange chromatography.$$\rm GluAsp(Glu\sb{17}Asp)\sb{x}GluGlu\

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15

Tsai, Ray-Ying, and 蔡睿盈. "Synthesis，Antiplatelet，Antiangiogenesis and Cytotoxicity Activity of 1-Benzyl-3-(5-substituted-2-furyl)-5-methoxy-1H-indazole Derivatives." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/68278761980375752184.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>91<br>Abstract 1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) was first synthesized in our laboratory as a novel antiplatelet agent. Encouraged by the initial results, a series of 5-methoxy derivatives of YC-1 analogues were synthesized and examined for their biological activities. The starting material methyl 5-(3-methoxybenzoyl)-2-furoate (1) was treated with benzylhydrazine to yield a mixture of E- and Z-form isomers 2. The hydrazone was then treated with lead tetraacetate in dichloromethane at low temperature, then boron trifluoride e

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16

Chang, Chiao-Kai, and 張喬凱. "Benzoyl Chloride Derivatives as the Self-Assembled Monolayer on Metal Oxide Surface in Organic Solar Cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/czdkvs.

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17

Chou, Hua-Cheng, and 周華晟. "Designed to Synthetic Benzyl Ether-Linked Glucuronide Derivative of Benzo[de]quinoline camptothecin(BQC) for Selective Anticancer Therapy." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/17913684817324924372.

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碩士<br>嘉南藥理科技大學<br>藥學系<br>101<br>5, 6-Dihydro-4H-benzo[de]quinolone camptothecin (BQC), a derivative of camptothecin, has been identified as a potential anti-tumor drug. Additionally, BQC could be conjugated with a methyl glucuronate to improve its tumor specificity and also its water solubility. Dr. Masamichi. firstly synthesized compound 6 from compound 1 through nitrification, oxidation and reduction. Compound 6 then was conjugated with compound 7 to give BQC. However, when the start material is compound 1, the nitrification step would produce a 6-nitro and 6, 8-dinitro byproduct, thus it re

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18

Soto, Carissa M. "Monodisperse benzyl -ester derivatives of poly(α, L-glutamate) and poly(α, L-aspartate) modeling nature's delicate state of matter". 2000. https://scholarworks.umass.edu/dissertations/AAI9960791.

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Biosynthesis of monodisperse poly(α,L-aspartic acid) and optimization of poly(α,L-glutamic acid) production have been accomplished. Protein design having as ultimate goal the synthesis of monodisperse benzyl-ester derivatives of α-helical polypeptides by genetic engineering has been performed. This comprises design of a monomeric DNA cassette, cloning, multimerization, ligation into an expression vector, and expression of the target gene followed by purification of the resultant protein. Advantages of such techniques include control of molecular size, composition, sequence and stereochemistry

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19

Jen-Chieh, Hsieh. "Application of Nickel Complexes on the Coupling Reactions and Annulations involving Benzyne, Isocyanate and 1,2-Diiodobenzene Derivatives." 2006. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0016-1303200709301533.

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20

Hsieh, Jen-Chieh, and 謝仁傑. "Application of Nickel Complexes on the Coupling Reactions and Annulations involving Benzyne, Isocyanate and 1,2-Diiodobenzene Derivatives." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/20375115204749616358.

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博士<br>國立清華大學<br>化學系<br>94<br>The thesis describes dipolar and nickel-catalyzed organic synthesis leading to coupling and cyclization of heterocyclic compounds. It is subdivided into four topics in four chapters. The first chapter describes nickel-catalyzed cyclization of aryne precursors with allene and diyne derivatives resulting in the formation of 9,10-dihydrophenanthrene and naphthalene derivatives in moderate to excellent yields. The second chapter extends the aryne precursors to precede 1,3-dipolar cycloaddition and coupling reaction with azide and isocyanate derivatives to form benzotri

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21

Metzger, Albrecht [Verfasser]. "Preparation and applications of benzylic zinc chlorides : lewis-acid promoted additions of organomagnesium and organozinc reagents to carbonyl derivatives ; transition metal-catalyzed cross-coupling reactions with methylthio-substituted N-heterocycles / von Albrecht Metzger." 2010. http://d-nb.info/1003615341/34.

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22

Hsu, Che-Hao, and 許哲豪. "Synthesis of Benzol Pyran Fused Carbazole Derivatives through Pictet-Spengler Reaction and Synthesis of the 4-Benzylidene-3,6-di-phenylhex-2-en-5-ynal Deriva- tives via One-Pot Palladium Catalysed Sonogashira and Hydroalkynylation Cascade Reactions." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/99080233803268094885.

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碩士<br>國立臺灣師範大學<br>化學系<br>102<br>This thesis consists two parts. In which the first part of thesis describes the preparation of benzopyran fused carbazole derivatives from (2R,3R,4S)-4-(1H-indol-3-yl)-2-phenylchroman-3-amine through Pictet-Spengler reaction. A wide variety of benzopyran fused carbazole derivatives were synthesized in this process in good to moderate yields. The second part deals with the Pd catalyzed one pot Sonogashira and hydroalkynylation cascade reactions to the synthesis of the 4-benzylidene-3,6-diphenylhex-2-en-5-ynal derivatives. This is an unprecedented result whe

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