Journal articles: 'BER'

1

Pricilya, Vyatri, Bambang Wirjatmadi, and Merryana Andriani. "DAYA TERIMA PROPORSI KACANG HIJAU (PHASEOLUS RADIATA L) DAN BEKATUL (RICE BRAN) TERHADAP KANDUNGAN SERAT PADA SNACK BAR." Media Gizi Indonesia 10, no. 2 (January 21, 2017): 136–40. http://dx.doi.org/10.20473/mgi.v10i2.136-140.

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Snack bar is a product made from cereal and nuts that usually consumed between meals. Commercial snack bar contains energy, protein, and ﬁber. The ﬁber content in it is usually 1 gram per 25 grams serving. The ﬁber content is relatively low because food categorized as high ﬁ ber if it has 5 grams per 100 gram products. Therefore, a new innovation to improve its ﬁ ber content is required. Green bean and rice bran are type of food with high ﬁber content that possible to be added in snack bar. The purpose of this research was to determine the acceptability and ﬁ ber content in snack bar. This was true experimental research with complete random design (CRD) with 5 treatments. Organoleptic test to assess acceptability of the snack bar was done by 5 trained panelists and 30 non trained panelists. Fiber contentwas calculated using Indonesia Food Composition Database and also analyzed by proximate test in laboratory. The result showed that formula 3 had the highest score than other formulas. Laboratory result showed ﬁ ber content in formula 3 was 1.98 grams per 25 grams snack bar. The conclusion of this research is the snack bar with proportion of green beans and rice bran has a good acceptability and higher ﬁ ber content compared to commercial snack bar.Keywords: ﬁ ber, green beans, rice bran, snack bar

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2

Poelt, Josef, and Helmut Mayrhofer. "�ber Cyanotrophie bei Flechten." Plant Systematics and Evolution 158, no. 2-4 (1987): 265–81. http://dx.doi.org/10.1007/bf00936350.

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3

Vallejo, Roger L., Wanda W. Collins, and Robert H. Moll. "Inheritance of A and B Glandular Trichome Density and Polyphenol Oxidase Activity in Diploid Potatoes." Journal of the American Society for Horticultural Science 119, no. 4 (July 1994): 829–32. http://dx.doi.org/10.21273/jashs.119.4.829.

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Glandular trichomes from some Solanum species have suppressed infestation by insects including green peach aphid, which is a main vector of potato virus Y (PVY) and potato leaf roll virus (PLRV), both of which contribute to a serious loss in potato production. Eight Solanum phureja Juz. et Buk.-S. stenotomum Juz. (Phu-Stn), three S. berthaultii Hawkes (Ber), nine F1 [(Phu-Stn) × Ber], fifteen backcross (BC) [(Phu-Stn) × F1], and seventeen reciprocal BC (BCR) [F1 × (Phu-Stn)] families were evaluated to determine the genetic variability and heritability of A and B glandular trichome density and polyphenol oxidase (PPO) activity. Experiments were carried out in completely randomized and randomized complete-block designs in the greenhouse. Genetic analysis was done using half-sib family and parent-offspring regression analysis. Phu-Stn showed a higher density of A trichomes than Ber and F1, while the BC and BCR had densities of A trichomes similar to Phu-Stn. B trichomes were not observed in Phu-Stn. Ber showed a high B trichome density, which was transmitted to the F1. In the BC, B trichomes were almost absent, but, in the BCR, the density of B trichomes was higher than that of BC. Ber and F1 had similar or higher PPO activity than Phu-Stn. PPO activity decreased in the BC, but, in the BCR, it was high and similar to Ber and F1. Broad-sense heritability estimates for A and B trichome density and PPO activity were from medium to high (0.48 to 0.77) in Phu-Stn, Ber, and F1. Narrow-sense heritability estimates for A and B trichome density and PPO activity were very low (0.04 to 0.24) in BC and BCR. In the BC families, additive genetic variance was very low for A and B trichome density and PPO activity. Half-sib family selection based on progeny testing and combined with BCs to Phu-Stn in subsequent generations would be a suggested breeding procedure to improve these traits. Phenotypic correlations between A and B trichome densities were 0.26 (F1) and 0.44 (BCR), between A trichome density and PPO activity 0.20 (F1) and 0.31 (BCR), and between B trichome density and PPO activity 0.04 (F1) and 0.27(BCR. Positive associations found between traits might facilitate simultaneous improvement for high levels of A and B trichome density and PPO activity.

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4

Mayo, Lisa, Gloria Miguel, and Muriel Miguel. "Reverb‐ber‐ber‐rations1." Women & Performance: a journal of feminist theory 5, no. 2 (January 1992): 184–212. http://dx.doi.org/10.1080/07407709208571159.

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5

Wolf, R., and R. Hoppe. "Neues �ber Oxouranate: �ber ?-Li6UO6. Mit einer Bemerkung �ber ?-Li6UO6." Zeitschrift f�r anorganische und allgemeine Chemie 528, no. 9 (September 1985): 129–37. http://dx.doi.org/10.1002/zaac.19855280914.

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6

Kindjic, Zoran. "Kantovo shvatanje uma." Filozofija i drustvo, no. 25 (2004): 43–99. http://dx.doi.org/10.2298/fid0525043k.

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(nemacki) Der Verfasser befasst sich zuerst mit den theoretischen und gesellschaftlich - geschichtlichen Voraussetzungen der Konzeption der Vernunft Kants. Kants Auseinandersetzung mit dem Problem der Metaphysik, wie auch die Aufgaben einer philosophischen Begr?ndung der Wissenschaft und einer Grundlegend der Ethik, haben die Einf?hrung eines Unterschieds zwischen Verstand und Vernunft, Kategorien und Ideen, bzw. der theoretischen und der praktischen Sph?re bedingt. Nach einer Betrachtung der Konstitution Rolle des Verstandes und des Regulativen Gebrauchs der Ideen in der theoretischen Sph?re untersuchte der Autor Kants Auffassung ?ber die Konsumtion Rolle der Vernunft in der praktischen Sph?re. Sich auf seine Lehre vom Primat der praktischen ?ber die theoretischen Vernunft, bzw. vom Primat der Moralit?t ?ber die Wissenschaft st?tzend, stellt der Verfasser fest, dass f?r eine Zivilisieren der Verstand gen?gt, aber f?r eine Moralisieren die Vernunft unentbehrlich ist. Bei seiner Betrachtung von Kants Versuch der ?berbr?ckung des Abgrunds zwischen Natur und Freiheit durch die Einf?hrung der reflektierenden Urteilskraft, verweist der Autor auf eine ?hnlichkeit zwischen der Vernunft und der reflektierenden Urteilskraft bez?glich ihrer Regulativen Rolle in der theoretischen Erkenntnis. Die Untersuchung des Verh?ltnisses zwischen Natur und Vernunft in der Philosophie von Kant, wie auch die Konfrontation der Konzeptionen der Vernunft von Kant und Hegel bietet die Voraussetzungen f?r das Verstehen eines ambivalenten Verh?ltnisses des K?nigsberg Denkers zur Revolution. Nach einer ?berpr?fung des Urteils von Lukacs ?ber Kant als einem typischen Vertreter des b?rgerlichen Denkens, er?rtert der Verfasser am Ende der Studie, ob uns Kants Philosophie helfen kann, die Krise zu ?berwinden, in der sich die Menschheit heute befindet. .

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7

Wagner, Klaus. "�ber den Steuerbarkeitsbegriff bei nichtlinearen Kontrollsystemen." Archiv der Mathematik 47, no. 1 (July 1986): 29–40. http://dx.doi.org/10.1007/bf01202497.

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8

Greher, M., P. Marhofer, M. Neuburger, and H. Kaiser. "Ber�cksichtigung der Anatomie bei Plexusblockade." Der Anaesthesist 53, no. 4 (April 2004): 374–75. http://dx.doi.org/10.1007/s00101-004-0655-7.

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9

K�hnau, Reiner. "�ber den Verschiebungsradius bei konformer Abbildung." Mathematische Annalen 299, no. 1 (May 1994): 779–84. http://dx.doi.org/10.1007/bf01459813.

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10

Scheffold, Egon. "�ber den Spektralradius bei kommutativen Banachverbandsalgebren." Archiv der Mathematik 44, no. 4 (April 1985): 365–68. http://dx.doi.org/10.1007/bf01235781.

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11

Lange, Christoph, and Andreas Ahrens. "Kanalkapazität vielpaariger symmetrischer Kupferkabel, Teil II: Ausnutzung der Fernnebensprechwege." Facta universitatis - series: Electronics and Energetics 19, no. 3 (2006): 355–70. http://dx.doi.org/10.2298/fuee0603355l.

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(nemacki) In den vielpaarigen symmetrischen Kupferkabeln der Ortsnetze begrenzt das Nebensprechen wesentlich die erreichbare ? bertragungskapazit?t. In einem zugeh ?rigen ersten Teil dieses Beitrages wurde die Kapazit?t von symmetrischen Leiterpaaren innerhalb vielpaariger Kabel bei St?rung durch Nah- und Fernnebensprechen in bidirektional betriebenen Kabeln sowie bei alleiniger Fernnebensprechst?rung in unidirektional genutzten Kabeln berechnet. In diesem zweiten Teil des Beitrages wird f?r unidirektional betriebene Kabel der Blickwinkel ver?ndert und die Kanalkapazit?t daf?r berechnet, dass die ?ber die Fernnebensprechpfade auf benachbarte Aderpaare ?bergekoppelten Signalanteile ebenso wie das direkt ?bertragene Signal als Nutzsignal betrachtet werden. Als Ergebnis zeigt sich, dass die Kanalkapazit?t von Kabelb ?ndeln durch die Ausnutzung des Fernnebensprechens gegen?ber der Kapazit?t von (fiktiven) B?ndeln mit perfekt geschirmten Einzelpaaren gesteigert werden kann. Noch weitaus deutlicher wird der erzielbare Kapazit?tsgewinn gegen?ber der praktisch relevanten Kapazit?t von Kabelb?ndeln mit nicht geschirmten Aderpaaren bei gegenseitiger Fernnebensprechst?rung. Mit zunehmender Anzahl in einem B?ndel zusammengefasster Aderpaare werden die erzielbaren Kapazit ?tsgewinne gr??er, wobei insbesondere bei kurzen Kabeln die Steigerung der Kanalkapazit?t durch Ausnutzung des Fernnebensprechens besonders deutlich ist.

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12

Manz, W., and G. Gattow. "�ber Chalkogenolate. 201. Untersuchungen �ber Selenformamide." Zeitschrift f�r anorganische und allgemeine Chemie 620, no. 1 (January 1994): 151–54. http://dx.doi.org/10.1002/zaac.19946200124.

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13

Djuric, Dragana. "Omen des todes im Volksglauben der Serben." Prilozi za knjizevnost, jezik, istoriju i folklor, no. 87 (2021): 19–32. http://dx.doi.org/10.2298/pkjif2187019d.

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Diese wissenschaftliche Arbeit analysiert den Volksglauben ?ber Todesomen bei Serben, untersucht deren Entstehung und deren heutige Relevanz. Der Forschungskorpus dieser Arbeit umfasst vor allem Monografien und wissenschaftliche Arbeiten zur Volkskultur der Serben, aber auch zu anderen s?dslawischen V?lkern. Nach traditionellem Glauben treten Haus- und Wildtiere (Hunde, Hahn, Huhn, Ochsen, Schlange, Kuckuck, Kr?he oder Rabe) als ?berbringer auf, welche den Tod ank?ndigen. Dar??ber hinaus wurden und werden heute noch pl?tzlich auftretende Ger?usche im Haus (Knarren, Zerbrechen von Geschirr), als auch Ph?nomene bei Bestattungsriten und christlichen Feiertagen als auch Tr?ume mit bestimmten Motiven als Omen, welche den Tod ank?ndigen interpretiert.

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14

Dibwe, Dya Fita, Emi Kitayama, Saki Oba, Nire Takeishi, Hitoshi Chiba, and Shu-Ping Hui. "Inhibition of Lipid Accumulation and Oxidation in Hepatocytes by Bioactive Bean Extracts." Antioxidants 13, no. 5 (April 25, 2024): 513. http://dx.doi.org/10.3390/antiox13050513.

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During our search for natural resources that can inhibit lipid droplet accumulation (LDA) and potentially prevent metabolic dysfunction-associated fatty liver disease (MAFLD) and its progressive stages, such as metabolic dysfunction-associated steatohepatitis (MASH), eight bean extracts (BE1–BE8) were tested for their ability to inhibit lipid accumulation and oxidation in hepatocytes. Substantial inhibitory effects on LDA with bean extracts (BEs) BE2, BE4, BE5, and BE8 were demonstrated. An advanced lipidomic approach was used to quantify the accumulation and inhibition of intracellular triacylglycerol (TAG) and its oxidized species, TAG hydroperoxide (TGOOH), in hepatocytes under fatty acid-loading conditions. The results show that the antioxidants BE2 and BE8 are potential candidates for regulating TAG and TGOOH accumulation in fatty acid-induced lipid droplets (LDs). This study suggests that bean-based foods inhibit LDs formation by decreasing intracellular lipids and lipid hydroperoxides in the hepatocytes. The metabolic profiling of BEs revealed that BE2 and BE8 contained polyphenolic compounds. These may be potential resources for the development of functional foods and drug discovery targeting MAFLD/MASH.

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15

Kochan, Jerzy. "Forgotten Marxist – Dow Ber Borochov." Nowa Krytyka 38 (2017): 9–22. http://dx.doi.org/10.18276/nk.2017.38-01.

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16

Crissiana, Sri Nitta, and Dita Aria Putri. "PENGARUH DEFERRED TAX EXPENSE, STRATEGI BISNIS DAN KEPEMILIKAN MANAJERIAL TERHADAP TAX AVOIDANCE." JOURNAL OF APPLIED MANAGERIAL ACCOUNTING 8, no. 1 (April 1, 2024): 178–87. http://dx.doi.org/10.30871/jama.v8i1.7329.

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Sumber penghasilan terbesar dari suatu negara berasal dari penerimaan pajak. Demi kelangsungan dan kesejahteraan negara yang dapat mempengaruhi pendapatan negara dan lajur perkembangan perekonomian. Bagi perusahaan melakukan pengeluaran pajak dari tanggungan perusahaan, melakukan penghindaraan pajak untuk meningkatkan laba yang besar dan likuiditas kelangsungan hidup perusahaan. pada Penelitian ini bertujuan untuk mendapatkan faktor yang membantu mengurangi pajak pada variabel dengan variabel indenpenden adalah Deferred Tax Expense, Strategi Bisnis Dan Kepemilikan Manajerial terhadap Tax Avoidance. Pengukuran metode purposive sampling dengan data kuantitatif dengan data skunder didapat dari laporan keuangan perusahaan tahunan propery dan realestate yang terdapat dan terdaftar diBursa Efek Indonesia (BEI) tahun 2018-2022. Maka kesimpulan penelitian yaitu kesimpulan pengukuran parsial deferred tax expense tidak ber pengaruh ter hadap tax avoidance, kepemilikan manajerial tidak ber pengaruh ter hadap tax aviodance dan strategi bisnis ber pengaruh negatif ter hadap tax aviodance, maka kesimpulan simultan variabel deferred tax expense, strategi bisnis dan kepemilikan manajerial ber pengaruh ter hadap tax avoidance. koefisien determinasi memiliki angka sebesar 86% maka menunjukan pengaruh yang diberikan variabel indenpenden terhadap variabel dependen memberikan nilai baik dan sisanya 14% yang di jelaskan variabel indenpenden lain yang tidak terdapat dipenelitian.

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17

Wu, Liang, Yue Xi, Man Yan, Chang Sun, Jiajun Tan, Jiayuan He, Haitao Li, and Dongxu Wang. "Berberine-Based Carbon Quantum Dots Improve Intestinal Barrier Injury and Alleviate Oxidative Stress in C57BL/6 Mice with 5-Fluorouracil-Induced Intestinal Mucositis by Enhancing Gut-Derived Short-Chain Fatty Acids Contents." Molecules 28, no. 5 (February 24, 2023): 2148. http://dx.doi.org/10.3390/molecules28052148.

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This study aims to evaluate the effect of berberine-based carbon quantum dots (Ber-CDs) on improving 5-fluorouracil (5-FU)-induced intestinal mucositis in C57BL/6 mice, and explored the mechanisms behind this effect. Thirty-two C57BL/6 mice were divided into four groups: normal control (NC), 5-FU-induced intestinal mucositis model (5-FU), 5-FU + Ber-CDs intervention (Ber-CDs), and 5-FU + native berberine intervention (Con-CDs). The Ber-CDs improved body weight loss in 5-FU-induced mice with intestinal mucositis compared to the 5-FU group. The expressions of IL-1β and NLRP3 in spleen and serum in Ber-CDs and Con-Ber groups were significantly lower than those in the 5-FU group, and the decrease was more significant in the Ber-CDs group. The expressions of IgA and IL-10 in the Ber-CDs and Con-Ber groups were higher than those in the 5-FU group, but the up-regulation was more significant in the Ber-CDs group. Compared with the 5-FU group, the relative contents of Bifidobacterium, Lactobacillus and the three main SCFAs in the colon contents were significantly increased the Ber-CDs and Con-Ber groups. Compared with the Con-Ber group, the concentrations of the three main short-chain fatty acids in the Ber-CDs group were significantly increased. The expressions of Occludin and ZO-1 in intestinal mucosa in the Ber-CDs and Con-Ber groups were higher than those in the 5-FU group, and the expressions of Occludin and ZO-1 in the Ber-CDs group were more higher than that in the Con-Ber group. In addition, compared with the 5-FU group, the damage of intestinal mucosa tissue in the Ber-CDs and Con-Ber groups were recovered. In conclusion, berberine can attenuate intestinal barrier injury and oxidative stress in mice to mitigate 5-fluorouracil-induced intestinal mucositis, moreover, the above effects of Ber-CDs were more significant than those of native berberine. These results suggest that Ber-CDs may be a highly effective substitute for natural berberine.

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18

Khaled, Azza M., Mohamed S. Othman, Sofian T. Obeidat, Ghada M. Aleid, Shimaa M. Aboelnaga, Alaa Fehaid, Heba M. R. Hathout, et al. "Green-Synthesized Silver and Selenium Nanoparticles Using Berberine: A Comparative Assessment of In Vitro Anticancer Potential on Human Hepatocellular Carcinoma Cell Line (HepG2)." Cells 13, no. 3 (February 5, 2024): 287. http://dx.doi.org/10.3390/cells13030287.

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A well-known natural ingredient found in several medicinal plants, berberine (Ber), has been shown to have anticancer properties against a range of malignancies. The limited solubility and bioavailability of berberine can be addressed using Ber-loaded nanoparticles. In this study, we compared the in vitro cytotoxic effects of both Ber-loaded silver nanoparticles (Ber-AgNPs) and Ber-loaded selenium nanoparticles (Ber-SeNPs) in the human liver cancer cell line (HepG2) and mouse normal liver cells (BNL). The IC50 values in HepG2 for berberine, Ber-AgNPs, Ber-SeNPs, and cisplatin were 26.69, 1.16, 0.04, and 0.33 µg/mL, respectively. Our results show that Ber and its Ag and Se nanoparticles exerted a good antitumor effect against HepG2 cells by inducing apoptosis via upregulating p53, Bax, cytosolic cytochrome C levels, and caspase-3 activity, and the down-regulation of Bcl-2 levels. Similarly, incubation with Ber and both Ber-NPs (Ag and Se) led to a significant dose-dependent elevation in inflammatory markers’ (TNF-α, NF-κB, and COX-2) levels compared to the control group. In addition, it led to the arrest of the G1 cell cycle by depleting the expression of cyclin D1 and CDK-2 mRNA. Furthermore, Ber and both Ber-NPs (Ag and Se) caused a significant dose-dependent increase in LDH activity in HepG2 cells. Furthermore, our findings offer evidence that Ber and its nanoparticles intensified oxidative stress in HepG2 cells. Furthermore, the migration rate of cells subjected to berberine and its nanoforms was notably decreased compared to that of control cells. It can be inferred that Ber nanoparticles exhibited superior anticancer efficacy against HepG2 compared to unprocessed Ber, perhaps due to their improved solubility and bioavailability. Furthermore, Ber-SeNPs exhibited greater efficacy than Ber-AgNPs, possibly as a result of the inherent anticancer characteristics of selenium.

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19

Jablanov-Maksimovic, Jelena. "Der Begriff des Anderen im Orthodoxen Christentum als integrierender Faktor für ein Zusammenleben im ehemaligen Jugoslawien." Filozofija i drustvo 24, no. 1 (2013): 359–78. http://dx.doi.org/10.2298/fid1301359j.

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Die vorliegende Arbeit besch?ftigt sich mit dem Begriff des Anderen/N?chsten/Bruders im Orthodoxen Christentum sowie im Rahmen von verschiedenen aktuellen gesellschaftlichen und politischen Diskursen, wie z. B. zwischenmenschliche Beziehungen, interreligi?ser Dialog oder der Dialog ?ber die Vergangenheit in die Post-Konflikt-Periode auf dem Balkan. Die ?berlegungen der Autorin basieren dabei auf einer Er?rterung des Ph?nomens von Nicht-Akzeptanz des Anderen und des Andersartigen bzw. auf einer Analyse der Angst vor dem Anderen/Andersartigen und des Hasses ihm gegen?ber. Von solchen negativen Einstellungen und Gef?hlen sind im betreffenden Zusammenhang nicht nur Menschen als Einzelne betroffen, sondern auch ganze ethnische Gruppen und Nationen. Als einer der Schl?sselfaktoren bei der Beziehung zum Anderen, bei einem friedlichen Miteinander mit ihm und sogar bei dem Vers?hnungsprozess im ehemaligen Jugoslawien wird dabei der Dialog verstanden und seine Bedeutung in dieser Rolle hervorgehoben. Er?rtert wird au?erdem die unterst?tzende Rolle, welche das orthodoxe Christentum bei der Entwicklung eines friedlichen Miteinanders sowie bei der Friedenserhaltung heute potenziell spielen k?nnte.

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20

Morhart, Alexander. "Simsala-BER." VDI nachrichten 74, no. 44 (2020): 12. http://dx.doi.org/10.51202/0042-1758-2020-44-12.

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Morhart, Alexander. "Simsala-BER." VDI nachrichten 74, no. 44 (2020): 12. http://dx.doi.org/10.51202/0042-1758-2020-44-12.

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22

Darras, Jacques. "Claude Ber." Esprit Novmbr, no. 11 (2014): 116. http://dx.doi.org/10.3917/espri.1411.0116.

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23

Plenker, Franz Peter. "�ber Wiedergutmachung." Forum der Psychoanalyse 18, no. 4 (December 1, 2002): 350–66. http://dx.doi.org/10.1007/s00451-002-0138-x.

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24

Thiele, G., H. Wochner, and H. Wagner. "�ber Osmiumbromide." Zeitschrift f�r anorganische und allgemeine Chemie 530, no. 11 (November 1985): 178–86. http://dx.doi.org/10.1002/zaac.19855301121.

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25

Wunderlich, C. H., R. Weber, and G. Bergerhoff. "�ber Eisengallustinte." Zeitschrift f�r anorganische und allgemeine Chemie 598, no. 1 (June 1991): 371–76. http://dx.doi.org/10.1002/zaac.19915980134.

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26

Wang, Zhiping, Junbiao Wu, Qun Zhou, Yifei Wang, and Tongsheng Chen. "Berberine Nanosuspension Enhances Hypoglycemic Efficacy on Streptozotocin Induced Diabetic C57BL/6 Mice." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/239749.

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Berberine (Ber), an isoquinoline derivative alkaloid and active ingredient of Coptis, has been demonstrated to possess antidiabetic activities. However its low oral bioavailability restricts its clinical application. In this report, Ber nanosuspension (Ber-NS) composed of Ber and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) was prepared by high pressure homogenization technique. Antidiabetic effects of Ber-NS relative to efficacy of bulk Ber were evaluated in streptozotocin (STZ) induced diabetic C57BL/6 mice. The particle size and zeta potential of Ber-NS were 73.1 ± 3.7 nm and 6.99 ± 0.17 mV, respectively. Ber-NS (50 mg/kg) treatment via oral gavage for 8 weeks resulted in a superior hypoglycemic and total cholesterol (TC) and body weight reduction effects compared to an equivalent dose of bulk Ber and metformin (Met, 300 mg/kg). These data indicate that a low dosage Ber-NS decreases blood glucose and improves lipid metabolism in type 2 diabetic C57BL/6 mice. These results suggest that the delivery of Ber as a nanosuspension is a promising approach for treating type 2 diabetes.

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Nieborowska-Skorska, Margaret, Artur Slupianek, Tomasz Stoklosa, Tomasz Poplawski, Kimberly Cramer, and Tomasz Skorski. "BCR/ABL Kinase Elevates ROS-Mediated Oxidative DNA Damage in CML Stem/Progenitor Cells and Affects the Efficiency and Fidelity of DNA Repair To Induce Genetic Instability." Blood 110, no. 11 (November 16, 2007): 34. http://dx.doi.org/10.1182/blood.v110.11.34.34.

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Abstract BCR/ABL kinase transforms hematopoietic stem cells (HSCs) to induce chronic myelogenous leukemia in chronic phase (CML-CP), which eventually evolves into fatal blast crisis (CML-BC). CML is a stem cell-derived but a progenitor-driven disease. In CML-CP leukemia stem (LSCs) and progenitor (LPCs) cells reside in CD34+CD38− and CD34+CD38+ populations, respectively, whereas in CML-BC LSCs are found also in CD34+CD38+ population. BCR/ABL kinase stimulates genomic instability causing imatinib-resistant point mutations and chromosomal aberrations associated with progression to CML-BC. Genomic instability may result from enhanced DNA damage and/or aberrant DNA repair mechanisms. We showed that CD34+ stem/progenitor CML cells contain higher levels of reactive oxygen species (ROS) than these from healthy donors (CML-BC>CML-CP>Normal). In addition, ROS were elevated in CD34+CD38− and CD34+CD38+ sub-populations isolated from CML-BC and CML-CP patients in comparison to cells from healthy donor. Higher ROS levels induced more oxidative DNA lesions such as oxidized bases (e.g., 8-oxoG) and DNA double-strand breaks (DSBs). ROS and oxidative DNA damage in CML stem/progenitor cells could be diminished by an antioxidant N-acetyl-cysteine. Moreover, inhibition of ROS by vitamin E reduced the frequency of imatinib-resistant BCR/ABL point mutants and chromosomal aberrations in leukemia cells in SCID mice. Cellular DNA repair systems act to remove DNA damage and ultimately preserve the informational integrity of the genome. Base excision repair (BER) and mismatch repair (MMR) are responsible for removal of oxidized bases. BER was assessed using single- and double-stranded DNA substrates containing 5-OH-U (a derivative of ROS-damaged hydroxy-deoxycytidine). MMR activity was measured by restoration of the expression of GFP from the construct containing T-G mismatch in the start codon. BCR/ABL kinase severely inhibited BER and MMR in cell lines and CD34+ CML cells, and promoted accumulation of point mutations in genes encoding BCR/ABL kinase and Na+/K+ ATPase. Inhibition of BCR/ABL kinase by imatinib restored BER and MMR activities. Oxidized bases, if not repaired, may lead to accumulation of DSBs observed in LSCs and LPCs. DSBs may be processed by homologous recombination (HR), non-homologous and-joininig (NHEJ), and single-strand annealing (SSA). HR represents faithful repair, NHEJ usually produces small deletions, and SSA causes very large deletions. Genome-integrated repair-specific reporter cassettes containing two disrupted fragments of the gene encoding GFP were used where a single DSB induced by I-SceI endonuclease in one of the fragments stimulated HR, NHEJ, or SSA. In general, BCR/ABL kinase enhanced DSBs repair activities, however at the expense of their fidelity. Numerous point mutations were introduced in HR repair products. NHEJ generated larger than usual deletions. SSA, rather rare but very unfaithful, was also induced in BCR/ABL-positive leukemia cells. In summary, BCR/ABL kinase enhanced ROS-mediated oxidative DNA damage in LSCs and LPCs. In addition, BCR/ABL inhibited BER and MMR of usually non-lethal oxidized DNA lesions leading to accumulation of point mutations. Moreover, BCR/ABL kinase stimulated HR, NHEJ and SSA of lethal DSBs, but compromised the fidelity of repair.

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Gattow, G., and H. M�ller. "�ber Chalkogenolate. 178. Untersuchungen �ber Kupfer(I)-ethylxanthat." Zeitschrift f�r anorganische und allgemeine Chemie 546, no. 3 (March 1987): 183–88. http://dx.doi.org/10.1002/zaac.19875460320.

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Chien, Fengsheng, Mojtaba Bakherad, and Mohammad Alomari. "Refined Berezin number inequalities via superquadratic and convex functions." Filomat 37, no. 1 (2023): 265–77. http://dx.doi.org/10.2298/fil2301265c.

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In this paper, we generalize and refine some Berezin number inequalities for Hilbert space operators. Namely, we refine the Hermite-Hadamard inequality and some other recent results by using the concept of superquadraticity and convexity. Then we extend these inequalities for the Berezin number. Among other inequalities, it is shown that if S, T ? L(H(?)) such that ber(T) ? ber(|S|) and f is a nonnegative superquadratic function, then f (ber (T)) ? ber(f (|S|)) ? ?ber (f (||S| ? ber (T)|)).

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Kim, B. Y., H. R. Park, H. G. Jeong, and S. W. Kim. "Berberine reduce allergic inflammation in a house dust mite allergic rhinitis mouse model." Rhinology journal 53, no. 4 (December 1, 2015): 353–58. http://dx.doi.org/10.4193/rhino15.028.

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Background: Berberine (Ber), used widely as an antibacterial, antifungal, and anti-inflammatory drug, has long been used as a gastrointestinal remedy in Chinese traditional medicine. Recent reports have suggested that Ber suppresses Th17 responses that was mediated by direct actions on T cells and thymic stromal lymphopoietin production in primary mast cells. It has been suggested that Ber may be useful in treating allergic response. The purpose of this study was to assess the effects of Ber treatment on allergic inflammation in an allergic rhinitis mouse model and to examine the underlying mechanism(s). Methods: BALB/c mice were divided into control, Derf with no treated (Derf), Ber treated, and Ber with anti-C25 monoclonal antibody treated (Ber + anti-CD25) groups. All mice, with the exception of the control group, were sensitized with an intraperitoneal i.p. injection of Dermatophagoides farinae (Derf). Mice in the Ber and Ber + anti-CD25 group were treated intranasally with 10 #181;g/mL. Then, 1 week after sensitization, all mice were challenged intranasally with 20 #181;g Derf for 5 consecutive days. Mice in the anti-CD25 group were treated intraperitoneally with 250 #181;g anti-CD25 monoclonal antibody 1 day before the first intra-nasal challenge with Derf. Allergic symptom scores, eosinophil counts, and serum Derf-specific IgE levels were measured. T-bet, GATA-3, interferon-g (IFN-γ), interleukin (IL)-10, IL-13, and Foxp3 expression was examined by real-time polymerase chain reaction and Western blotting. CD4⁺ CD25⁺ Foxp3⁺ T cells were assessed by flow cytometry. Results: Symptom scores, serum Derf-specific IgE levels, GATA-3 mRNA levels, T-bet mRNA levels, and tissue eosinophil counts were decreased in the Ber versus the Derf group. In the Ber + anti-CD25 group, serum IL-10 levels were decreased versus the control, Derf, and Ber groups. In the Ber + anti-CD25 mAb groups, Foxp3 mRNA levels were decreased versus the control group. In the Ber group, Foxp3 mRNA levels were increased versus the control group. In the Ber group, the percentage of CD4⁺ CD25⁺ Foxp3⁺ T cells was increased versus the Derf group. The percentage of CD4⁺ CD25⁺ Foxp3+ T cells was increased in the Ber versus the Derf groups. Conclusions: In our study, Ber reduced allergic inflammation significantly. Moreover, our findings suggest that the mechanism of action of Ber may be via CD4⁺ CD25⁺ Foxp3⁺ Treg cells, possibly through not only by increasing their numbers but also altering their function.

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Krwawicz, Joanna, Katarzyna D. Arczewska, Elzbieta Speina, Agnieszka Maciejewska, and Elzbieta Grzesiuk. "Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease." Acta Biochimica Polonica 54, no. 3 (September 24, 2007): 413–34. http://dx.doi.org/10.18388/abp.2007_3219.

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Base excision repair (BER) pathway executed by a complex network of proteins is the major system responsible for the removal of damaged DNA bases and repair of DNA single strand breaks (SSBs) generated by environmental agents, such as certain cancer therapies, or arising spontaneously during cellular metabolism. Both modified DNA bases and SSBs with ends other than 3'-OH and 5'-P are repaired either by replacement of a single or of more nucleotides in the processes called short-patch BER (SP-BER) or long-patch BER (LP-BER), respectively. In contrast to Escherichia coli cells, in human ones, the two BER sub-pathways are operated by different sets of proteins. In this review the selection between SP- and LP-BER and mutations in BER and end-processors genes and their contribution to bacterial mutagenesis and human diseases are considered.

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Wirth, Alberto. "«BER DIE SYNKRONISIERUNG DER IMPULSE BEI KLINISCHEM ELEKTRORETINOGRAMM»." Acta Ophthalmologica 30, no. 4 (May 27, 2009): 399–403. http://dx.doi.org/10.1111/j.1755-3768.1952.tb00015.x.

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Sang-Yeop Lee. "Eine Untersuchung ber ein ideales Menschenbild bei Nietzsche." Journal of Korean Nietzsche-Society ll, no. 11 (April 2007): 121–52. http://dx.doi.org/10.16982/jkns.2007..11.005.

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Poletto, Mattia, Lisa Lirussi, David M. Wilson, and Gianluca Tell. "Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins." Molecular Biology of the Cell 25, no. 10 (May 15, 2014): 1641–52. http://dx.doi.org/10.1091/mbc.e13-12-0717.

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Nucleophosmin (NPM1) is a multifunctional protein that controls cell growth and genome stability via a mechanism that involves nucleolar–cytoplasmic shuttling. It is clear that NPM1 also contributes to the DNA damage response, yet its exact function is poorly understood. We recently linked NPM1 expression to the functional activation of the major abasic endonuclease in mammalian base excision repair (BER), apurinic/apyrimidinic endonuclease 1 (APE1). Here we unveil a novel role for NPM1 as a modulator of the whole BER pathway by 1) controlling BER protein levels, 2) regulating total BER capacity, and 3) modulating the nucleolar localization of several BER enzymes. We find that cell treatment with the genotoxin cisplatin leads to concurrent relocalization of NPM1 and BER components from nucleoli to the nucleoplasm, and cellular experiments targeting APE1 suggest a role for the redistribution of nucleolar BER factors in determining cisplatin toxicity. Finally, based on the use of APE1 as a representative protein of the BER pathway, our data suggest a function for BER proteins in the regulation of ribogenesis.

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Effendi, Rustam. "PERSAMAAN DAN PERBEDAAN PREFIKS BER- DALAM BAHASA INDONESIA DAN BA- DALAM BAHASA BANJAR (SIMILARITIES AND DIFFERENCES IN THE PREFIX BER- IN INDONESIAN AND BA- IN BANJARESE)." JURNAL BAHASA, SASTRA DAN PEMBELAJARANNYA 9, no. 1 (April 16, 2019): 80. http://dx.doi.org/10.20527/jbsp.v9i1.6251.

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AbstractSimilarities and Differences in the Prefix ber- in Indonesian and ba- in Banjarese.Prefixes ber- and ba- in Indonesia and Banjarese have similarities and differences interms of forms, fungtions, and meanings. The similarities is due to the fact thatIndonesia and Banjarese have the same origin, wich comes from Malay. The prefikxber- in Indonesia has three allomorphs namely ber-, be-, and bel- while the Banjareseonly two, namely ba- and bal. Ber- and ba- functions are the same as formingintransitive verbs, but ba- in Banjar language can also function to form transitive verbs.The meaning of ber- and ba- has many similarities but there are also differences.Prefixes ba-, for example, can mean ‘more or intentionally doing a work’ as examplepanjang → bapanjang; kaina → bakaina, and gugur → bagugur.Key words: ber- prefix, ba- prefix, Indonesian language, Banjar languageAbstrakPersamaan dan Perbedaan Prefiks Ber- dalam Bahasa Indonesia dan Ba- dalambahasa Banjar. Prefiks ber- dalam bahasa Indonesia dan ba- dalam bahasa Banjarmemiliki persamaan dan perbedaan dalam hal bentuk, fungsi, dan makna. Persamaanitu disebabkan bahwa bahasa Indonesia dan bahasa Banjar memiliki asal yang samayakni berasal dari bahasa Melayu. Prefiks ber- dalam bahasa Indonesia memiliki tigaalomorf, yakni ber-, be-, dan bel-, sedangkan bahasa Banjar hanya memiliki duaalomorf, yakni ba- dan bal-. Fungsi ber- dan ba- sama-sama sebagai pembentuk katakerja intranstif, namun, ba- dalam bahasa Banjar dapat juga berfungsi untukmembentuk kata kerja transitif, seperti pada baunjun sapat ‘mengail ikan sepat’, danlain-lain. Makna ber- dan ba- memiliki banyak kesamaan, namun ada pulaperbedaannya. Prefiks ba-, misalnya, dalam bahasa Banjar dapat mengandung makna‘semakin, dengan sengaja melakukan suatu pekerjaan’ apabila ba- itu berhubungandengan kata adjektiva, seperti panjang → bapanjang, kaina → bakaina, gugur →bagugur, dan lain-lain.Kata-kata kunci: prefiks ber-, prefiks ba-, bahasa Indonesia, bahasa Banjar

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Othman, Mohamed S., Amal H. Al-Bagawi, Sofian T. Obeidat, Mohamed A. Fareid, Ola A. Habotta, and Ahmed E. Abdel Moneim. "Antitumor Activity of Zinc Nanoparticles Synthesized with Berberine on Human Epithelial Colorectal Adenocarcinoma (Caco-2) Cells through Acting on Cox-2/NFkB and p53 Pathways." Anti-Cancer Agents in Medicinal Chemistry 22, no. 10 (June 2022): 2002–10. http://dx.doi.org/10.2174/1871520621666211004115839.

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Background: Drawbacks and side effects of currently available therapies to colorectal cancer (CRC) have compelled researchers to search for new therapeutic strategies. Objective: This study was designed to investigate the effects of zinc nanoparticles biosynthesized with berberine (ZnNPs-BER) on Caco-2 cells compared to 5-Fluorouracil (5-FU) and explore the possible underlying pathways. Methods: Caco-2 and Vero cells were treated with 5-FU, BER, or ZnNPs-BER for 24 h. Cell viability was measured by MTT assay. Oxidative stress and apoptotic markers and cell cycle were determined. Additionally, Cox-2 and NF-kB levels were also measured. Results: The IC50 values of 5-FU, BER, and ZnNPs-BER on Caco-2 cells were found to be 34.65 μM, 19.86 μg/ml and 10.49 μg/ml, respectively by MTT assay. The IC50 value for 5-FU in Vero cells was 21.7 μg/ml, however, BER and BER-ZnNPs treatment showed non-toxic effects on the Vero cells. Further, ZnNPs-BER exerted significant induction of ROS besides exhaustion of the antioxidant capacity of tumor cells indicated by a decline in GSH and elevated NO and MDA contents. Marked increments in levels of Bax and caspase-3 were detected together with declines in Bcl- 2 levels in Caco-2 cells subjected to BER-ZnNPs therapy. On the molecular basis, upregulation in mRNA levels of pro-apoptotic genes (Bax, caspase-3, and tumor suppressor gene p53) along with downregulation in the anti-apoptotic gene (Bcl-2) were observed in ZnNPs-BER treated Caco-2 cells. Furthermore, ZnNPs-BER showed more pronounced effects on apoptosis increased cell percentage in the S and subG1 phases. In addition, green synthesis of ZnNPs with BER showed notable induction of Cox2 and NF-kB in Caco-2 cells. Conclusion: Therefore, the antitumor potential of ZnNPs-BER in colon cancer cells may be endorsed for induction of oxidative stress, inflammation, and apoptotic changes in tumor cells. Our study documents the therapeutic potential of Zn nanoparticles conjugated with BER, which may be a new option for combined chemotherapy.

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Othman, Mohamed S., Amal H. Al-Bagawi, Sofian T. Obeidat, Mohamed A. Fareid, Ola A. Habotta, and Ahmed E. Abdel Moneim. "Antitumor Activity of Zinc Nanoparticles Synthesized with Berberine on Human Epithelial Colorectal Adenocarcinoma (Caco-2) Cells through Acting on Cox-2/NFkB and p53 Pathways." Anti-Cancer Agents in Medicinal Chemistry 22, no. 10 (June 2022): 2002–10. http://dx.doi.org/10.2174/1871520621666211004115839.

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Background: Drawbacks and side effects of currently available therapies to colorectal cancer (CRC) have compelled researchers to search for new therapeutic strategies. Objective: This study was designed to investigate the effects of zinc nanoparticles biosynthesized with berberine (ZnNPs-BER) on Caco-2 cells compared to 5-Fluorouracil (5-FU) and explore the possible underlying pathways. Methods: Caco-2 and Vero cells were treated with 5-FU, BER, or ZnNPs-BER for 24 h. Cell viability was measured by MTT assay. Oxidative stress and apoptotic markers and cell cycle were determined. Additionally, Cox-2 and NF-kB levels were also measured. Results: The IC50 values of 5-FU, BER, and ZnNPs-BER on Caco-2 cells were found to be 34.65 μM, 19.86 μg/ml and 10.49 μg/ml, respectively by MTT assay. The IC50 value for 5-FU in Vero cells was 21.7 μg/ml, however, BER and BER-ZnNPs treatment showed non-toxic effects on the Vero cells. Further, ZnNPs-BER exerted significant induction of ROS besides exhaustion of the antioxidant capacity of tumor cells indicated by a decline in GSH and elevated NO and MDA contents. Marked increments in levels of Bax and caspase-3 were detected together with declines in Bcl- 2 levels in Caco-2 cells subjected to BER-ZnNPs therapy. On the molecular basis, upregulation in mRNA levels of pro-apoptotic genes (Bax, caspase-3, and tumor suppressor gene p53) along with downregulation in the anti-apoptotic gene (Bcl-2) were observed in ZnNPs-BER treated Caco-2 cells. Furthermore, ZnNPs-BER showed more pronounced effects on apoptosis increased cell percentage in the S and subG1 phases. In addition, green synthesis of ZnNPs with BER showed notable induction of Cox2 and NF-kB in Caco-2 cells. Conclusion: Therefore, the antitumor potential of ZnNPs-BER in colon cancer cells may be endorsed for induction of oxidative stress, inflammation, and apoptotic changes in tumor cells. Our study documents the therapeutic potential of Zn nanoparticles conjugated with BER, which may be a new option for combined chemotherapy.

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Jia, Li, Kuijin Xue, Junheng Liu, Ola A. Habotta, Lianhai Hu, Ahmed E. Abdel Moneim, and Daniela Caccamo. "Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways." Mediators of Inflammation 2020 (September 28, 2020): 1–12. http://dx.doi.org/10.1155/2020/9419085.

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Berberine (BER), a natural isoquinoline alkaloid, has been demonstrated to have appreciable anticolitis effects. Nevertheless, the protective mechanism of BER in ulcerative colitis (UC) is barely understood. The present study was aimed at exploring the therapeutic efficacy of BER on UC in experimental colitis rat model. Rats were orally administered with BER for seven days at low and high doses (25 and 50 mg/kg/day) before AcOH intracolonic instillation. BER significantly retrieved colon inflammation and mucosal damage indicated by inhibition of macroscopic score and lessened the levels of inflammatory biomarkers (IL-1β, IL-6, TNF-α, MPO, and PGE2). Notable downregulation of mRNA expression of p38 MAPK and increased protein expression of TGF-β were achieved by BER treatment. The anti-inflammatory potential of BER was supported by the histopathological screening of colon mucosa. In addition, BER restored colonic antioxidant capacity through elevation of GSH level and antioxidant enzymatic activities (SOD, CAT, GPx, and GR) together with reductions of both MDA and NO levels. Marked downregulation of Nos2 mRNA expression is accompanied by increased Nrf2 and Hmox-1 expressions in colon specimens treated by BER. Furthermore, BER exhibited noticeable antiapoptotic activities through decreasing proapoptotic proteins (Bax and caspase-3) and lessening antiapoptotic Bcl-2 protein in the colon mucosa. Based on these findings, BER may improve colitis markedly which may be mediated by its striking antioxidant, anti-inflammatory, and antiapoptotic properties.

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Rakhmania, Amalia Eka, Akhmad Mukhibuddin Harvinanda, Hudiono Hudiono, Aad Hariyadi, Hadiwiyatno, and Mochammad Taufik. "Analisis Kinerja Sistem Modulasi Downlink LTE dan 5G pada Kanal AWGN Berbasis MATLAB." Techné : Jurnal Ilmiah Elektroteknika 22, no. 2 (December 5, 2023): 217–40. http://dx.doi.org/10.31358/techne.v22i2.341.

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Pada penelitian ini dilakukan analisis performansi downlink LTE dan 5G dengan menggunakan MATLAB. Penelitian ini bertujuan untuk menganalisis perbandingan kinerja teknik modulasi QPSK, 16-QAM, dan 64-QAM yang digunakan pada downlink LTE dan teknik modulasi QPSK, 16-QAM, 64-QAM, dan 256-QAM pada downlink 5G yang melalui kanal AWGN untuk mengetahui nilai BER pada teknik modulasi yang digunakan. Teknik multiplexing yang digunakan adalah OFDM dan CP-OFDM untuk downlink LTE dan CP-OFDM untuk downlink 5G dengan variasi cyclic prefix yang digunakan adalah kategori ”normal”. Pada downlink LTE, kinerja modulasi QPSK lebih baik dari 16-QAM dan 64-QAM. Pada OFDM, BER QPSK diperoleh 10-19 pada Eb/No 16 dB, BER 16-QAM diperoleh 10-19 pada Eb/No 20 dB dan BER 64-QAM diperoleh 10-8 pada Eb/No 20 dB. Pada CP-OFDM, BER QPSK diperoleh 10-20 pada Eb/No 16 dB, BER 16-QAM diperoleh 10-19 pada Eb/No 20 dB dan BER 64-QAM diperoleh 10-9 pada Eb/No 20 dB. Pada downlink 5G CP-OFDM, kinerja modulasi QPSK lebih baik dari 16-QAM, 64-QAM dan 256-QAM, BER QPSK diperoleh 10-24 pada Eb/No 16 dB, BER 16-QAM diperoleh 10-23 pada Eb/No 20 dB, BER 64-QAM diperoleh 10-14 pada Eb/No 20 dB, dan BER 256-QAM diperoleh 10-7 pada Eb/No 20 dB.

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Ott, R., and E. Pinter. "Untersuchungen �ber Chinone, 9. Mitt. �ber Acetylderivate vonp-Indazolchinonen." Monatshefte f�r Chemie Chemical Monthly 125, no. 8-9 (1994): 945–54. http://dx.doi.org/10.1007/bf00812709.

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Wolf, R., and R. Hoppe. "�ber Li8PrO6 und Li8TbO6 (Mit einer Bemerkung �ber Li8CeO6)." Zeitschrift f�r anorganische und allgemeine Chemie 522, no. 3 (1985): 39–47. http://dx.doi.org/10.1002/zaac.19855220306.

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Gattow, G., and S. Lotz. "�ber Chalkogenolate. 167. Untersuchungen �ber 1,2-Hydrazin-bis(monothioformiate)." Zeitschrift f�r anorganische und allgemeine Chemie 533, no. 2 (February 1986): 109–17. http://dx.doi.org/10.1002/zaac.19865330214.

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Horak, Iryna, Svitlana Prylutska, Iryna Krysiuk, Serhii Luhovskyi, Oleksii Hrabovsky, Nina Tverdokhleb, Daria Franskevych, et al. "Nanocomplex of Berberine with C60 Fullerene Is a Potent Suppressor of Lewis Lung Carcinoma Cells Invasion In Vitro and Metastatic Activity In Vivo." Materials 14, no. 20 (October 15, 2021): 6114. http://dx.doi.org/10.3390/ma14206114.

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Effective targeting of metastasis is considered the main problem in cancer therapy. The development of herbal alkaloid Berberine (Ber)-based anticancer drugs is limited due to Ber’ low effective concentration, poor membrane permeability, and short plasma half-life. To overcome these limitations, we used Ber noncovalently bound to C60 fullerene (C60). The complexation between C60 and Ber molecules was evidenced with computer simulation. The aim of the present study was to estimate the effect of the free Ber and C60-Ber nanocomplex in a low Ber equivalent concentration on Lewis lung carcinoma cells (LLC) invasion potential, expression of epithelial-to-mesenchymal transition (EMT) markers in vitro, and the ability of cancer cells to form distant lung metastases in vivo in a mice model of LLC. It was shown that in contrast to free Ber its nanocomplex with C60 demonstrated significantly higher efficiency to suppress invasion potential, to downregulate the level of EMT-inducing transcription factors SNAI1, ZEB1, and TWIST1, to unblock expression of epithelial marker E-cadherin, and to repress cancer stem cells-like markers. More importantly, a relatively low dose of C60-Ber nanocomplex was able to suppress lung metastasis in vivo. These findings indicated that сomplexation of natural alkaloid Ber with C60 can be used as an additional therapeutic strategy against aggressive lung cancer.

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Grebinyk, Anna, Svitlana Prylutska, Anatoliy Buchelnikov, Nina Tverdokhleb, Sergii Grebinyk, Maxim Evstigneev, Olga Matyshevska, et al. "C60 Fullerene as an Effective Nanoplatform of Alkaloid Berberine Delivery into Leukemic Cells." Pharmaceutics 11, no. 11 (November 8, 2019): 586. http://dx.doi.org/10.3390/pharmaceutics11110586.

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A herbal alkaloid Berberine (Ber), used for centuries in Ayurvedic, Chinese, Middle-Eastern, and native American folk medicines, is nowadays proved to function as a safe anticancer agent. Yet, its poor water solubility, stability, and bioavailability hinder clinical application. In this study, we have explored a nanosized carbon nanoparticle—C60 fullerene (C60)—for optimized Ber delivery into leukemic cells. Water dispersions of noncovalent C60-Ber nanocomplexes in the 1:2, 1:1, and 2:1 molar ratios were prepared. UV–Vis spectroscopy, dynamic light scattering (DLS), and atomic force microscopy (AFM) evidenced a complexation of the Ber cation with the negatively charged C60 molecule. The computer simulation showed that π-stacking dominates in Ber and C60 binding in an aqueous solution. Complexation with C60 was found to promote Ber intracellular uptake. By increasing C60 concentration, the C60-Ber nanocomplexes exhibited higher antiproliferative potential towards CCRF-CEM cells, in accordance with the following order: free Ber < 1:2 < 1:1 < 2:1 (the most toxic). The activation of caspase 3/7 and accumulation in the sub-G1 phase of CCRF-CEM cells treated with C60-Ber nanocomplexes evidenced apoptosis induction. Thus, this study indicates that the fast and easy noncovalent complexation of alkaloid Ber with C60 improved its in vitro efficiency against cancer cells.

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Kumar, Addanki Pratap, Alison Clark, Michelle Villarreal, Sridharan Jayamohan, Shih-Bo Huang, Suleman S. Hussain, Xiaoyu Yang, et al. "Abstract 4: Intercepting ribosomal protein S6KB1 signaling: Prevention of prostate cancer recurrence." Cancer Research 82, no. 12_Supplement (June 15, 2022): 4. http://dx.doi.org/10.1158/1538-7445.am2022-4.

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Abstract There is an urgent need for innovative strategies such as the discovery of adjuvants that can prevent relapse and improve quality of life for patients treated with radiotherapy. Previously we demonstrated the utility of Nexrutine (Nex) as a neo-adjuvant with radiation. Nex was safe and well tolerated in PCa patients and potentiated radiation response in part through downregulation of ribosomal protein S6K (encoded byRPS6KB1). We now show that RPS6KB1 depleted prostate cancer cells with higher basal levels of γ-H2AX, a marker for DNA double strand breaks (i) are more sensitive to radiation and (ii) form smaller tumors with reduced levels of prostate specific antigen (PSA). Depletion of RPS6KB1 hindered DNA double-strand break repair predominantly through the alternate end-joining pathway, induction of G2/M checkpoint and NFκB pathway activation. Collectively these events led to improved radiation sensitivity. We further identified Berberine (Ber), one of the active constituents of Nex as a potential pharmacological inhibitor of RPS6KB1. In an orthotopic implantation model of C4-2B, treatment with Ber alone or Ber plus radiation decreased PSA levels that was sustained during the course of the experiment. On the other hand animals treated with radiation alone developed recurrent cancer as evidenced by a resurgence of PSA. Animals administered Ber followed by XRT intervention had increased levels of RANTES while there was no change in animals that received XRT followed by Ber. The observed reversal of the Bereffect with the sequence of intervention is statistically significant (p=0.0298). Among animals not subject to XRT, the mean PSA increased in those that did not receive Ber relative to those that did; mean difference=-1.93, 95% CI -3.75 to -0.105, p=0.04 with no significant changes in body weight. Notably,RPS6KB1 mRNA levels increased in tumor samples in patients experiencing biochemical recurrence(BCR). Given that rising PSA following conventional therapeutic approaches such as radiation remain a major clinical challenge, targeting RPS6KB1 signaling with radiation therapy is an attractive strategy to prevent BCR. Supported in part by CPRIT RP190012 (APK). Citation Format: Addanki Pratap Kumar, Alison Clark, Michelle Villarreal, Sridharan Jayamohan, Shih-Bo Huang, Suleman S. Hussain, Xiaoyu Yang, Paul Rivas, Darpan Patel, Bethany L. Pierce, Shreya Tripathy, Pawel Osmulski, Maria Gaczynska, Lai Zhao, Li-Ju Wang, Yidong Chen, Caroline Xavier Paul Ezhilan, Mohan Natarajan, Joel E. Michalek, Robert L. Reddick, Rita Ghosh. Intercepting ribosomal protein S6KB1 signaling: Prevention of prostate cancer recurrence [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 4.

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Liu, Hongxiang, Yifan Li, Xiaoying Zhang, Man Shi, Dexu Li, and Ying Wang. "Chitosan-Coated Solid Lipid Nano-Encapsulation Improves the Therapeutic Antiairway Inflammation Effect of Berberine against COPD in Cigarette Smoke-Exposed Rats." Canadian Respiratory Journal 2022 (April 15, 2022): 1–13. http://dx.doi.org/10.1155/2022/8509396.

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Berberine (Ber) is an isoquinoline alkaloid that has shown therapeutic potential in mice with chronic obstructive pulmonary disease (COPD). However, the therapeutic efficiency of Ber is restricted by its low aqueous solubility and bioavailability. Chitosan and solid lipid nanoparticles (SLNs) have demonstrated great abilities as delivery systems in enhancing the bioavailability of therapeutic compounds. The present study aimed to get together the biological features of SLNs with the advantages of chitosan to formulate an efficient nano-carrier platform for the oral delivery of Ber and evaluate the therapeutic effect of the prepared Ber-encapsulated nanoparticles on airway inflammation in cigarette smoke (CS)-induced COPD rats. The Ber-encapsulated SLE-chitosan formulation was manufactured using a modified solvent-injection method followed by a homogenization process. Physicochemical properties, encapsulation efficiency, in vitro stability and Ber release, and pharmacokinetics of the manufactured formulation were evaluated. The COPD rat model was developed by exposing animals to CS. To study the therapeutic efficiency of Ber-encapsulated SLE-chitosan nanoparticles and pure berberine, the histopathological changes of the lung tissues, levels of inflammatory cells and cytokines, and activities of myeloperoxidase (MPO) and superoxide dismutase (SOD) enzymes were evaluated in bronchoalveolar lavage fluid (BALF). Ber-encapsulated SLE-chitosan showed the particle size in nano-range with high stability and controlled slow-release profile in vitro in simulated gastric (pH 1.5) and intestinal (pH 6.8) fluids. Administration of Ber-loaded SLE-chitosan nanoparticles could significantly ameliorate inflammation scores in lung tissues and reduce levels of inflammatory cells (neutrophils and macrophages) and inflammatory cytokines (IL-1β, Il-6, Il-17, and TNFα) in BALF when compared with the pure Ber. SLE-chitosan-based nanoparticles can strongly improve the therapeutic anti-inflammatory impact of Ber against CS-induced airway inflammation in COPD rats, suggesting the promising application of Ber-encapsulated SLN-chitosan nanoparticles for treating COPD and other inflammation-mediated diseases.

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Calvo, Alba, Esther Moreno, Esther Larrea, Carmen Sanmartín, Juan Manuel Irache, and Socorro Espuelas. "Berberine-Loaded Liposomes for the Treatment of Leishmania infantum-Infected BALB/c Mice." Pharmaceutics 12, no. 9 (September 9, 2020): 858. http://dx.doi.org/10.3390/pharmaceutics12090858.

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Berberine (BER)—an anti-inflammatory quaternary isoquinoline alkaloid extracted from plants—has been reported to have a variety of biologic properties, including antileishmanial activity. This work addresses the preparation of BER-loaded liposomes with the aim to prevent its rapid liver metabolism and improve the drug selective delivery to the infected organs in visceral leishmaniasis (VL). BER liposomes (LP-BER) displayed a mean size of 120 nm, negative Z-potential of −38 mV and loaded 6 nmol/μmol lipid. In vitro, the loading of BER in liposomes enhanced its selectivity index more than 7-fold by decreasing its cytotoxicity to macrophages. In mice, LP-BER enhanced drug accumulation in the liver and the spleen. Consequently, the liposomal delivery of the drug reduced parasite burden in the liver and spleen by three and one logarithms (99.2 and 93.5%), whereas the free drug only decreased the infection in the liver by 1-log. The organ drug concentrations—far from IC50 values— indicate that BER immunomodulatory activity or drug metabolites also contribute to the efficacy. Although LP-BER decreased 10-fold—an extremely rapid clearance of the free drug in mice—the value remains very high. Moreover, LP-BER reduced plasma triglycerides levels.

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48

Apriani and Reni Latifani. "Identifikasi Klorin pada Tepung Terigu (Ber Merek dan Tidak Ber Merek) dan Tepung Beras (Ber Merek)." Jurnal Health Sains 1, no. 6 (December 24, 2020): 360–65. http://dx.doi.org/10.46799/jhs.v1i6.64.

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Klorin adalah bahan kimia yang biasa digunakan sebagai pembunuh kuman. Peraturan Menteri Kesehatan RI No. 772/Menkes/Per/XI/88, bahwa klorin tidak tercatat sebagai Bahan Tambahan Pangan (BTP) dalam kelompok pemutih dan pematang tepung. Penelitian ini bertujuan untuk mengetahui apakah ada atau tidaknya klorin pada jenis tepung terigu dan tepung beras secara kualitatif dan untuk mengetahui kadar klorin didalam tepung secara kuantitatif. Penelitian ini dilakukan dengan desain deskriptif kuantitatif yaitu dengan pengulangan sebanyak 3 kali dan metode yang digunakan yaitu kualitatif dengan reaksi warna dan kuantitatif dengan spektrofotometer. Penelitian ini dilakukan di UPT Laboratorium Kesehatan Daerah Kota Tangerang. Hasil uji kualitiatif menunjukkan 100% tepung terigu bermerk dan tidak bermerk serta tepung beras bermerk positif mengandung klorin. Kadar klorin tertinggi terdapat pada tepung terigu ber merek SN yaitu .

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Umiyati, Annisa, Bagus Surya Pratama, Nur Aini, and Widya Ayu Kesumastuti. "AFIKS DERIVASIONAL BER- PADA MEDIA MASSA INDONESIA." Hasta Wiyata 4, no. 2 (July 1, 2021): 81–105. http://dx.doi.org/10.21776/ub.hastawiyata.2021.004.02.01.

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News is part of the mass media that is easily accessible to all people. News has the characteristics of language is short, concise and objective. The use of language in writing news must pay attention to the writing of word structures, word formation in accordance with PUEBI. One of the word formation that occurs is the result of affixation process. One of the productive affixes in Indonesian is the prefix ber-. This study discusses the derivational affixes contained in mass media coverage in Indonesia. Data sources came from national, regional, and local online mass media during the period of September 2020. Data were obtained using observation methods and note-taking techniques. Data were analyzed using the split method with direct element sharing techniques. The use of the affix on the Indonesian mass media in the form of Ber+N= V has the meaning (1) in the state; (2) obtain, produce; (3) have; and (4) reflexive. Whereas Ber+A= V means 'in a state'. Ber+Adv.= V means 'in a state'. Ber+N= Num. has the meaning of 'collection / collective', and Ber+bound morpheme= V has the meaning (1) 'in a state'; (2) 'have'. Variations in the use of affixes are mostly carried out in the national media and the affixes of ber- which are not yet available in the Kridalaksana book are Ber+Adv.= V, Ber+N= Num. , and Ber+bound morpheme= V.

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Abo El-Enin, Hadel A., Mohammed H. Elkomy, Ibrahim A. Naguib, Marwa F. Ahmed, Omar A. Alsaidan, Izzeddin Alsalahat, Mohammed M. Ghoneim, and Hussein M. Eid. "Lipid Nanocarriers Overlaid with Chitosan for Brain Delivery of Berberine via the Nasal Route." Pharmaceuticals 15, no. 3 (February 24, 2022): 281. http://dx.doi.org/10.3390/ph15030281.

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This research aimed to design, optimize, and evaluate berberine-laden nanostructured lipid carriers overlaid with chitosan (BER-CTS-NLCs) for efficient brain delivery via the intranasal route. The nanostructured lipid carriers containing berberine (BER-NLCs) were formulated via hot homogenization and ultrasonication strategy and optimized for the influence of a variety of causal variables, including the amount of glycerol monostearate (solid lipid), poloxamer 407 (surfactant) concentration, and oleic acid (liquid lipid) amount, on size of the particles, entrapment, and the total drug release after 24 h. The optimal BER-NLCs formulation was then coated with chitosan. Their diameter, in vitro release, surface charge, morphology, ex vivo permeability, pH, histological, and in vivo (pharmacokinetics and brain uptake) parameters were estimated. BER-CTS-NLCs had a size of 180.9 ± 4.3 nm, sustained-release properties, positive surface charge of 36.8 mV, and augmented ex-vivo permeation via nasal mucosa. The histopathological assessment revealed that the BER-CTS-NLCs system is safe for nasal delivery. Pharmacokinetic and brain accumulation experiments showed that animals treated intranasally with BER-CTS-NLCs had substantially greater drug levels in the brain. The ratios of BER brain/blood levels at 30 min, AUCbrain/AUCblood, drug transport percentage, and drug targeting efficiency for BER-CTS-NLCs (IN) were higher compared to BER solution (IN), suggesting enhanced brain targeting. The optimized nanoparticulate system is speculated to be a successful approach for boosting the effect of BER in treating CNS diseases, such as Alzheimer’s disease, through intranasal therapy.

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