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Journal articles on the topic 'Beremin model'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Golisch, Georg, Sebastian Münstermann, and Wolfgang Bleck. "Influence of the Stress State on the Predictability of the Failure Probability in the Beremin Model." Applied Mechanics and Materials 784 (August 2015): 403–10. http://dx.doi.org/10.4028/www.scientific.net/amm.784.403.

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The influence of the local state of stress on the predictability of the Beremin model is investigated. For this purpose, the Beremin model is used on a series of tensile experiments with varying constraints. One specimen series is used to calibrate the Beremin parameters. These are afterwards applied to all specimen series. For all series the test results are compared to the predicted 5% to 95% failure probability corridor calculated by the Beremin model. The results are then discussed in concern of the influence of the stress state on the predictability of the Beremin model.
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2

Qian, Guian, V. F. González-Albuixech, and Markus Niffenegger. "Calibration of Beremin model with the Master Curve." Engineering Fracture Mechanics 136 (March 2015): 15–25. http://dx.doi.org/10.1016/j.engfracmech.2015.02.003.

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3

Pan, Jianhua, and Mengle Yin. "Investigation on Beremin parameters based on the toughness scaling model." Engineering Fracture Mechanics 247 (April 2021): 107697. http://dx.doi.org/10.1016/j.engfracmech.2021.107697.

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4

Lefevre, W., G. Barbier, R. Masson, and G. Rousselier. "A modified Beremin model to simulate the warm pre-stress effect." Nuclear Engineering and Design 216, no. 1-3 (July 2002): 27–42. http://dx.doi.org/10.1016/s0029-5493(02)00067-5.

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5

Koundy, V., S. Renevey, B. Marini, and A. Combescure. "Effects of Torsional Buckling on the Cleavage Failure of Low-Alloy Steel Tension Pipe Specimens." Journal of Pressure Vessel Technology 120, no. 3 (August 1, 1998): 256–61. http://dx.doi.org/10.1115/1.2842055.

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The local approach criterion of fracture mechanics, initially developed by Beremin for brittle cleavage fracture, is applied here to A508 class 3 low-alloy ferritic steel. This criterion, based on the maximum principal stress and Weibull statistics, has previously been verified in the case of uniaxial tests. In this study, it is extended to multiaxial loading tests, that can lead to more significant levels of plastic strain, and thus permit a study of the effect of plastic strain on cleavage fracture. Uniaxial tests on axisymmetric notched tensile bars (AE2-6) were used to determine Beremin’s model parameters m and σu. The cleavage fracture behavior, described by these parameters, was then verified by multiaxial tension-torsion tests carried out on thin tubular specimens. Numerical simulations of the tension-torsion tests, by the finite element method, were also performed, taking into account the nonlinear geometrical effects and the specimen plastic buckling. The buckling critical loads were calculated and used to ascertain whether fracture was associated with the instability phenomenon. Beremin’s model is shown to correctly describe experimental data which are not affected by buckling.
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6

Cao, Yupeng, Hu Hui, Guozhen Wang, and Fu-Zhen Xuan. "Inferring the temperature dependence of Beremin cleavage model parameters from the Master Curve." Nuclear Engineering and Design 241, no. 1 (January 2011): 39–45. http://dx.doi.org/10.1016/j.nucengdes.2010.11.009.

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7

Andrieu, A., A. Pineau, J. Besson, D. Ryckelynck, and O. Bouaziz. "Bimodal Beremin-type model for brittle fracture of inhomogeneous ferritic steels: Theory and applications." Engineering Fracture Mechanics 95 (November 2012): 84–101. http://dx.doi.org/10.1016/j.engfracmech.2011.10.016.

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8

Andrieu, A., A. Pineau, J. Besson, D. Ryckelynck, and O. Bouaziz. "Beremin model: Methodology and application to the prediction of the Euro toughness data set." Engineering Fracture Mechanics 95 (November 2012): 102–17. http://dx.doi.org/10.1016/j.engfracmech.2011.10.019.

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9

Mathieu, Jean-Philippe, Karim Inal, Sophie Berveiller, and Olivier Diard. "A micromechanical interpretation of the temperature dependence of Beremin model parameters for french RPV steel." Journal of Nuclear Materials 406, no. 1 (November 2010): 97–112. http://dx.doi.org/10.1016/j.jnucmat.2010.02.025.

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10

Burstow, M. C. "A re-assessment of parameter tuning for the Beremin model using the toughness scaling technique." International Journal of Pressure Vessels and Piping 80, no. 11 (November 2003): 797–805. http://dx.doi.org/10.1016/j.ijpvp.2003.01.004.

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11

Hojo, Kiminobu, Naoki Ogawa, Takatoshi Hirota, Kentaro Yoshimoto, Yasuto Nagoshi, and Shinichi Kawabata. "Application of Coupled Damage and Beremin Model to Ductile-Brittle Transition Temperature Region Considering Constraint Effect." Procedia Structural Integrity 2 (2016): 1643–51. http://dx.doi.org/10.1016/j.prostr.2016.06.208.

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12

Bernauer, G., W. Brocks, and W. Schmitt. "Modifications of the Beremin model for cleavage fracture in the transition region of a ferritic steel." Engineering Fracture Mechanics 64, no. 3 (October 1999): 305–25. http://dx.doi.org/10.1016/s0013-7944(99)00076-4.

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13

Beleznai, R., and Sz Szavai. "Application of the Beremin Model for Cruciform Specimen to Determine the Fracture Probability in Case of WPS." Strength of Materials 45, no. 4 (July 2013): 489–94. http://dx.doi.org/10.1007/s11223-013-9484-8.

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14

Hu, Hui, Yu Peng Cao, and Pei Ning Li. "Study on Fracture Toughness Prediction of Non Power Law Hardening Material by Using Local Approach." Advanced Materials Research 197-198 (February 2011): 1640–46. http://dx.doi.org/10.4028/www.scientific.net/amr.197-198.1640.

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A new method of fracture toughness K1C prediction of non power law hardening material by using cleavage fracture local approach is proposed in this paper. The fracture toughness of A508-Ⅲ 16MnR at different cleavage fracture probability are predicted by using the method. To most of pressure vessel carbon-manganese steels, cleavage fracture is likely to occur at the load corresponding to 62% cleavage fracture probability. Hence, the fracture toughness corresponding to the load is the most possible fracture toughness of the steels. The values of fracture toughness corresponding to 62% cleavage fracture probability is close to that of testing fracture toughness. The work of this paper expends the application of Beremin cleavage fracture model in predicting fracture toughness.
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15

Hadidi-Moud, Saeid, A. Mirzaee-Sisan, Christopher E. Truman, and David John Smith. "Comparison of Global and Local Approaches to Predicting Warm Pre-Stress Effect on Cleavage Fracture of Ferritic Steels." Key Engineering Materials 261-263 (April 2004): 69–74. http://dx.doi.org/10.4028/www.scientific.net/kem.261-263.69.

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Potentially both global and local approaches may be used to predicting the effect of loading history on cleavage fracture toughness distribution of ferritic steels. In this paper the dramatic increase in the apparent lower shelf fracture toughness of A533B steel following warm pre-stressing (WPS) has been predicted using these approaches. Extensive experimental evidence suggesting significant enhancement in fracture toughness of ferritic steels within the lower shelf temperatures following WPS are used to verify and compare the applicability and the extent of validity of the models. The global approach is based on the distribution of toughness data described by Wallin statistical model in conjunction with the Chell model for WPS effect. The local approach on the other hand is a Beremin type model that uses the Weibull stress to predict the WPS effect. Weibull stresses would essentially reflect the WPS effect on redistribution of stress-state around the crack tip. Predictions for apparent toughness using the two approaches are discussed in the light of the suggestion that residual stresses are the main cause of the enhancement, at least for the material and geometry used in this study.
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16

Ko, Han Ok, Sun Jung Kang, Yoon Suk Chang, Jae Boong Choi, Young Jin Kim, Min Chul Kim, and Bong Sang Lee. "Development of Toughness Scale Diagram Considering Temperature Dependency." Key Engineering Materials 345-346 (August 2007): 513–16. http://dx.doi.org/10.4028/www.scientific.net/kem.345-346.513.

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Fracture toughness data from the cleavage resistance test of structural steels often show a large scatter. Geometry dependency as well as the scatter makes it difficult to evaluate appropriate fracture integrity of cracked components. To address these restrictions, several stochastic models have been proposed by Beremin group, Mudry and other researchers while each of them employs specific estimation scheme and micro-mechanical parameters. The purpose of this paper is to investigate applicability of the Weibull stress model in transition temperature regime and to quantify constraint effect among different-sized CT and PCVN specimens. The constituting parameters m and σu are determined at three temperatures by maximum likelihood estimate (MLE) technique in use of FE analysis results and experimental data of PCVN specimens. Also, failure probabilities of PCVN and CT specimens are calculated from the Weibull parameters, which are used for derivation of a prototype of toughness scale diagram. The diagram provides a technical basis to resolve transferability issue in the same material under different temperatures and constraint conditions.
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17

Karabegov, Alexander V. "A Formal Model of Berezin-Toeplitz Quantization." Communications in Mathematical Physics 274, no. 3 (July 13, 2007): 659–89. http://dx.doi.org/10.1007/s00220-007-0291-6.

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18

Popescu, Gelu. "Noncommutative Berezin transforms and multivariable operator model theory." Journal of Functional Analysis 254, no. 4 (February 2008): 1003–57. http://dx.doi.org/10.1016/j.jfa.2007.06.004.

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19

DERIGLAZOV, A. A. "NONRELATIVISTIC SPIN: à la BEREZIN–MARINOV QUANTIZATION ON A SPHERE." Modern Physics Letters A 25, no. 32 (October 20, 2010): 2769–77. http://dx.doi.org/10.1142/s0217732310033980.

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Reparametrization invariant dynamics on a sphere, being parametrized by angular momentum coordinates, represents an appropriate framework for semiclassical description of nonrelativistic spin. The space can be quantized according to Berezin–Marinov prescription, replacing the coordinates by Pauli matrices. Following the scheme, we present two semiclassical models for describing spin without the use of Grassmann variables. The first model implies Pauli equation upon the canonical quantization. The second model produces nonrelativistic limit of the Dirac equation implying correct value for the electron spin magnetic moment.
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20

Carrillo-Ibarra, I., H. García-Compeán, and W. Herrera-Suárez. "Berezin quantization of gauged WZW and coset models." General Relativity and Gravitation 38, no. 4 (February 16, 2006): 663–76. http://dx.doi.org/10.1007/s10714-006-0256-7.

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21

BALEANU, DUMITRU, and SAMI I. MUSLIH. "FRACTIONAL EULER-LAGRANGE AND FRACTIONAL HAMILTON EQUATIONS FOR SUPER SYMMETRIC CLASSICAL MODEL." Fractals 15, no. 04 (December 2007): 379–83. http://dx.doi.org/10.1142/s0218348x07003642.

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Fractional Euler-Lagrange equations were investigated in the presence of the elements of Berezin algebra. The super fractional Hessian was defined and the fractional Hamiltonian of the super symmetric classical model was constructed.
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22

RANDJBAR-DAEMI, S., and J. STRATHDEE. "A FOUR-FERMION LATTICE MODEL." International Journal of Modern Physics A 10, no. 32 (December 30, 1995): 4651–69. http://dx.doi.org/10.1142/s0217751x95002151.

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The weak coupling limit of an Ising type model on the F4 lattice is examined. It is shown that by imposing some constraints on the Ising couplings, one can express the weak coupling limit as a multidimensional Berezin integral with local symmetries, We explore the possibility of deriving a fermion propagator by a self-consistent, Nambu-Jona-Lasinio type of calculation. We argue that at low energies this model describes Dirac fermions coupled to Yang-Mills fields.
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23

Stezhko, Nadiia Volodymyrivna. "DEVELOPMENT OF MODEL SCENARIOS FOR FOOD PRODUCTION AND CONSUMPTION FORECASTS IN TERMS OF SOLVING GLOBAL FOOD PROBLEM." SCIENTIFIC BULLETIN OF POLISSIA 1, no. 2(14) (March 1, 2018): 70–78. http://dx.doi.org/10.25140/2410-9576-2018-1-2(14)-70-78.

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Urgency of the research. Food problem issues take a prominent place in national security concepts of every developed country. In the context of Ukraine’s commitment to integration into the European community, the food problem is of prominent significance. Target setting. Given the global economy dynamics, the research of this problem is not exhaustive and needs new approaches to scientific research. Actual scientific researches and issues analysis. The problems of food support of the population reflected in the works of L. Brown (2011), O. Berezin (2011), L. Berezina (2011), V. Vlasov (2009), M. Lysak (2009), R. Maltus (1998), B. Paskhaver (2007), M. Puhachov (2014), A. Sen (1979), Ya. Stoliarchuk (2009), etc. Uninvestigated parts of general matters defining. Existing mechanisms of formation and distribution of world food resources, international trade therein, and food aid do not create an efficient system to ensure sufficient food support around the world. Therefore, it is important to reason the forecast ratio of deficit and domestic production for certain types of food to satisfy the demand under WHO standards. The research objective. The purpose of the article is to identify the most and least vulnerable countries in terms of food security through the forecast ratio of deficit (shortage) and domestic production for certain types of food to satisfy the demand under WHO standards in particular parts of the world. The statement of basic materials. Prospects for tackling the global food issue by using trend, adaptive and integrated autoregressive models (Box-Jenkins and OLYMPUS models) have been analysed. The calculations herein have been provided by different parts of the world: Africa, America, Asia, Europe, and Oceania. Conclusions. The results show that almost all parts of the world are unable to provide the population with rational norms of major foods through domestic production.
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24

Moattari, Mastaneh, Iradj Sattari-Far, Italo Persechino, and Nicola Bonora. "Prediction of fracture toughness in ductile-to-brittle transition region using combined CDM and Beremin models." Materials Science and Engineering: A 657 (March 2016): 161–72. http://dx.doi.org/10.1016/j.msea.2015.12.090.

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25

Bitonti, A. J., J. A. Dumont, and P. P. McCann. "Characterization of Trypanosoma brucei bruceiS-adenosyl-l-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal bis(guanylhydrazone)." Biochemical Journal 237, no. 3 (August 1, 1986): 685–89. http://dx.doi.org/10.1042/bj2370685.

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Trypanosoma brucei brucei S-adenosyl-L-methionine (AdoMet) decarboxylase was found to be relatively insensitive to activation by putrescine as compared with the mammalian enzyme, being stimulated by only 50% over a 10,000-fold range of putrescine concentrations. The enzyme was not stimulated by up to 10 mM-Mg2+. The Km for AdoMet was 30 microM, similar to that of other eukaryotic AdoMet decarboxylases. T.b. brucei AdoMet decarboxylase activity was apparently irreversibly inhibited in vitro by Berenil and reversibly by pentamidine and methylglyoxal bis(guanylhydrazone). Berenil also inhibited trypanosomal AdoMet decarboxylase by 70% within 4 h after administration to infected rats and markedly increased the concentration of putrescine in trypanosomes that were exposed to the drug in vivo. Spermidine and spermine blocked the curative effect of Berenil on model mouse T.b. brucei infections. This effect of the polyamines was probably not due to reversal of Berenil's inhibitory effects on the AdoMet decarboxylase.
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26

BOGOLUBOV, N. N., and Y. A. PRYKARPATSKY. "THE MARSDEN–WEINSTEIN REDUCTION STRUCTURE OF INTEGRABLE DYNAMICAL SYSTEMS AND A GENERALIZED EXACTLY SOLVABLE QUANTUM SUPERRADIANCE MODEL." International Journal of Modern Physics B 27, no. 08 (March 15, 2013): 1350002. http://dx.doi.org/10.1142/s0217979213500021.

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An approach to describing nonlinear Lax type integrable dynamical systems of modern mathematical and theoretical physics, based on the Marsden–Weinstein reduction method on canonically symplectic manifolds with group symmetry, is proposed. Its natural relationship with the well-known Adler–Kostant–Souriau–Berezin–Kirillov method and the associated R-matrix approach is analyzed. A new generalized exactly solvable spatially one-dimensional quantum superradiance model, describing a charged fermionic medium interacting with external electromagnetic field, is suggested. The Lax type operator spectral problem is presented, the related R-structure is calculated. The Hamilton operator renormalization procedure subject to a physically stable vacuum is described, the quantum excitations and quantum solitons, related with the thermodynamical equilibrity of the model, are discussed.
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27

Schmitt, T. "Supergeometry and Quantum Field Theory, or: What is a Classical Configuration?" Reviews in Mathematical Physics 09, no. 08 (November 1997): 993–1052. http://dx.doi.org/10.1142/s0129055x97000348.

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We discuss the conceptual difficulties connected with the anticommutativity of classical fermion fields, and we argue that the "space" of all classical configurations of a model with such fields should be described as an infinite-dimensional supermanifold M. We discuss the two main approaches to supermanifolds, and we examine the reasons why many physicists tend to prefer the Rogers approach although the Berezin–Kostant–Leites approach is the more fundamental one. We develop the infinite-dimensional variant of the latter, and we show that the superfunctionals considered in [44] are nothing but superfunctions on M. We propose a programme for future mathematical work, which applies to any classical field model with fermion fields. A part of this programme will be implemented in the successor paper [45].
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28

Garbacz, Jerzy K., Karol Karpiński, and Mariusz Kozakiewicz. "Molecular Dimerisation in a Multilayer Adsorption Phase on Homogeneous Surfaces of a Solid Adsorbent." Polish Hyperbaric Research 67, no. 2 (June 1, 2019): 59–68. http://dx.doi.org/10.2478/phr-2019-0006.

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Abstract Continuing the discussion on the description of adsorbate-adsorbate association on homogeneous surfaces of solids, an attempt was made to formulate an analytical form of adsorption equation for a multilayer adsorption phase. The validity of Berezin’s and Kiselev’s assumptions concerning the independence of adsorption in further layers from the model of the phenomenon in the first of them was discussed. The fundamental validity of this assumption has been demonstrated, simultaneously ridding it of its arbitrary character. The main aim of the study was to demonstrate the possibility of formulating a description assuming molecule association in the entire adsorption phase (and not only in the first layer). Theoretical considerations are confined to the case of dimerisation in the concentration range thus warranting the approximation characteristic of the Berezin and Kiselev model. The obtained final adsorption equation exhibits physically acceptable boundary properties; with adequate assumptions it amounts to the Brunauer, Emmett and Teller equation, the equation formulated earlier by one of the authors of this paper or the Langmuir equation.
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29

Kranabetter, Christine. "Laser in der Tierphysiotherapie – Grundlagen und Anwendung." Hands on - Manuelle und Physikalische Therapien in der Tiermedizin 3, no. 01 (April 2021): 19–25. http://dx.doi.org/10.1055/a-1395-0674.

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Der Laser hat heute seinen festen Platz in der physikalischen Therapie gefunden. Die Medizintechnik hält unzählige Modelle bereit – aber welches Modell erfüllt auch die Anforderungen für meine Therapieanforderungen? Im Folgenden erläutern wir in einer Übersicht gängige Wellenlängen, Ausgangsleistungen und Emissionstypen sowie deren Vor- und Nachteile in der Anwendung als Entscheidungshilfe für den effizienten Einsatz.
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30

GAZEAU, JEAN-PIERRE, FRANCOIS-XAVIER MICHAUX, and PASCAL MONCEAU. "FINITE DIMENSIONAL QUANTIZATIONS OF THE (q,p) PLANE: NEW SPACE AND MOMENTUM (OR QUADRATURES) INEQUALITIES." International Journal of Modern Physics B 20, no. 11n13 (May 20, 2006): 1778–91. http://dx.doi.org/10.1142/s0217979206034285.

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We present a N-dimensional quantization à la Berezin-Klauder or frame quantization of the complex plane based on overcomplete families of states (coherent states) generated by the N first number eigenstates. The spectra of position and momentum operators (or of quadrature operators in quantum optics) are finite and eigenvalues are equal, up to a factor, to the zeros of Hermite polynomials. From numerical and theoretical studies of the large N behavior of the product λm(N) λM(N) of non null smallest positive and largest eigenvalues, we infer the inequality [Formula: see text] (resp. [Formula: see text]) involving, in suitable units, the minimal (δN(Q)) and maximal (ΔN(Q)) sizes of regions of space (resp. momentum) which are accessible to exploration within this finite-dimensional quantum framework. Interesting issues on the measurement process and connections with the finite Chern-Simons matrix model for the Quantum Hall effect are discussed.
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31

Perilo, Cecília Steinberg, Márcio Tadeu Pereira, Marcelo Matos Santoro, and Ronaldo Alves Pinto Nagem. "Structural binding evidence of the trypanocidal drugs Berenil® and Pentacarinate® active principles to a serine protease model." International Journal of Biological Macromolecules 46, no. 5 (June 2010): 502–11. http://dx.doi.org/10.1016/j.ijbiomac.2010.03.006.

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32

Bhargavi, K., P. Shyamala, M. Padma, and K. V. Nagalakshmi. "Kinetic Study of SN2 Reaction between Paranitrophenyl Benzoate and Hydrazine in the Presence of CTAB Reverse Micelles." Bulletin of Chemical Reaction Engineering & Catalysis 16, no. 4 (August 3, 2021): 744–51. http://dx.doi.org/10.9767/bcrec.16.4.11036.744-751.

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Kinetic study of the reaction between p-Nitrophenyl benzoate (PNPB) by hydrazine (HYN) in the presence of Cetyltrimethylammonium bromide (CTAB)/Chloroform/Hexane reverse micellar medium shows that the reaction obeys first order kinetics with respect to each of the reactants. The rate of the reaction is much slower in reverse micellar medium compared to aqueous medium under identical conditions (kˈAq = 2.84×10−3 sec−1, krm =1.34×10−4 sec−1). The rate constants for the reaction in the reverse micellar medium have been determined at different values of W {W=[H2O]/[CTAB]} and at different concentrations of CTAB. It was found that the observed rate constant decreases with W. This kinetic behaviour was interpreted by using modified Berezin pseudo phase model, taking into consideration the distribution of the reactants, PNPB and hydrazine between the three pseudo phases, i.e., water pool, interface an organic phase. Copyright © 2021 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
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33

Dombrowski, Uwe, Michael Kaufmann, and Yannick Dix. "Stufenmodell zur Steigerung der Termintreue/Increase of adherence to schedules by Industrie 4.0." wt Werkstattstechnik online 111, no. 04 (2021): 206–11. http://dx.doi.org/10.37544/1436-4980-2021-04-28.

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Die Termintreue nimmt als produktionslogistische Zielgröße eine exponierte Stellung ein, da sie die Kundenzufriedenheit unmittelbar beeinflusst und Lieferterminabweichungen oftmals an Vertragsstrafen gebunden sind. Dieser Beitrag stellt ein Stufenmodell bereit, um die Terminierungssicherheit durch Integration von Ansätzen der Industrie 4.0 in die Durchlaufterminierung systematisch zu unterstützten.   Adherence to schedules takes an exposed position as a production-logistic objective, as it directly influences customer satisfaction and delivery date deviations are often linked to contractual penalties. This paper provides a stage-model to support systematically the scheduling security by integrating Industrie 4.0 approaches into the scheduling process.
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34

Czarnomysy, Robert, Dominika Radomska, Anna Muszyńska, Justyna Magdalena Hermanowicz, Izabela Prokop, Anna Bielawska, and Krzysztof Bielawski. "Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole." Molecules 25, no. 12 (June 21, 2020): 2860. http://dx.doi.org/10.3390/molecules25122860.

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Novel transition metal complexes (Au, Pd, Pt) with berenil and 2-(1-methyl-5-nitroimidazol-2-yl)ethanol were obtained through two-step synthesis. The cytotoxicity assay against MCF-7 and MDA-MB-231 breast cancer cells revealed that novel platinum and palladium complexes cause a reduction on the viability of MCF-7 and MDA-MB-231 breast cancer cells to a greater extent than cisplatin. The complexes showed lower cytotoxicity on normal MCF-10A human breast epithelial cells than on tumor cells. Furthermore, we observed that these complexes selectively concentrate in tumor cell mitochondria due to the characteristic for these cells increased membrane potential that may explain their increased proapoptotic activity. The activity of the synthesized compounds against topoisomerase type IIα and their increased impact on DNA defragmentation also were documented. The novel complexes also induced autophagosome changes and inhibited tumor growth in xenograft models (established using breast cancer cells).
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35

Apprich, S., F. Wulle, A. Prof Pott, and A. Prof Verl. "Exakte posenabhängige Strukurmodelle*/Accurate virtual machine tool structures - Online-identification of the general model of a lightweight machine tool structure with pose-dependent dynamic behavior." wt Werkstattstechnik online 107, no. 05 (2017): 323–28. http://dx.doi.org/10.37544/1436-4980-2017-05-19.

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Serielle Werkzeugmaschinenstrukturen weisen ein posenabhängiges, dynamisches Verhalten auf, wobei die Eigenfrequenzen um mehrere Hertz im Arbeitsraum variieren können. Die genaue Kenntnis dieses Verhaltens gestattet eine verbesserte Regelung der Strukturen. Ein generelles parametrisches Maschinenmodell, dessen Parameter online durch einen Recursive-Least-Squares-Algorithmus an das reale Maschinenverhalten angepasst werden, stellt Informationen über dieses Maschinenverhalten bereit.   Serial machine tool structures feature a pose-dependent dynamic behavior with natural frequencies varying by serveral hertz within the working space. The accurate knowledge of this behavior allows an improved control of the structures. A general parametric machine model, whose parameters are adapted online to the actual machine tool behavior by a Recursive Least Squares algorithm, provides information about the pose-dependent dynamic behavior.
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Bacchi, Cyrus J., Marcus Vargas, Donna Rattendi, Burt Goldberg, and Weicheng Zhou. "Antitrypanosomal Activity of a New Triazine Derivative, SIPI 1029, In Vitro and in Model Infections." Antimicrobial Agents and Chemotherapy 42, no. 10 (October 1, 1998): 2718–21. http://dx.doi.org/10.1128/aac.42.10.2718.

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ABSTRACT A recently developed diaminotriazine derivative [O,O′-bis(1,2-dihydro-2,2-tetramethylene-4,6-diamino-S-triazin-1-yl)-1,6-hexanediol dihydrochloride; T-46; SIPI 1029] was examined for activity against African trypanosomes in in vitro and in vivo model systems. In vitro, SIPI 1029 was 50% inhibitory for growth of bloodstream trypomastigotes of four strains of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense at 0.15 to 2.15 nM (50% inhibitory concentrations). In in vivo mouse laboratory models of T. b. rhodesiense clinical isolate infections, SIPI 1029 was curative for 12 of 13 isolates at ≤10 mg/kg of body weight/day for 3 days. In eight infections, a single dose was ≥60% curative, and in six of these, a dose of ≤5 mg/kg was sufficient for ≥60% cure rates. A number of these isolates were resistant to the standard trypanocide melarsoprol (Arsobal) and/or the diamidines diminazene aceturate (Berenil) and pentamidine. SIPI 1029 was also curative in combination withdl-α-difluoromethylornithine (Ornidyl) in a T. b. brucei central nervous system model infection. Some evidence of toxicity was found in dosage regimens of 10 mg/kg/day for 2 or 3 days in which deaths were observed in 6 of 65 animals given this dosage regimen. The activity of SIPI 1029 in this study indicates that this class of compounds (diaminotriazines) should be explored as leads for new human and veterinary trypanocides.
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Gansefort, Dirk, Manuela Peters, and Tilman Brand. "Wie bereit ist die Kommune? Das Community Readiness-Modell und die beispielhafte Anwendung in der kommunalen Gesundheitsförderung." Das Gesundheitswesen 82, no. 11 (April 28, 2020): 868–76. http://dx.doi.org/10.1055/a-1119-6181.

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ZusammenfassungDas 2015 verabschiedete Präventionsgesetz sieht eine Stärkung settingbasierter Präventionsansätze vor. Ziel der vorliegenden Arbeit ist die Vorstellung des Community Readiness-Modells als ein Instrument zur Bedarfsermittlung und Verbesserung gesundheitsförderlicher Strukturen im Setting Kommune am Beispiel Bewegungsförderung im Alter im Rahmen des Forschungsprojekts Ready to Change. Community Readiness steht dabei für kommunale Handlungsbereitschaft. Die Bedarfsermittlung im Rahmen der Modell-Umsetzung erfolgt als Community Readiness-Assessment, bei dem an Themen der Gesundheitsförderung und Prävention angepasste Leitfaden-gestützte Interviews mit Schlüsselpersonen in Kommunen geführt werden. Als Ergebnis wird für die Kommunen ein Stadium der Handlungsbereitschaft identifiziert, aus dementsprechend zu ergreifende Public Health-Maßnahmen abgeleitet werden. In unserem Beispiel wurde das Modell an das Thema Bewegungsförderung im Alter im kommunalen Setting angepasst. Ein Assessment wurde im Jahr 2015 in 23 Kommunen im Nordwesten Deutschlands durchgeführt. Für die Ergebnisdarstellung des Assessments werden beispielhaft Darstellungen wie Spinnweb-Diagramme und geographische Verteilungen präsentiert. Mit dem Community Readiness-Ansatz liegt ein Modell vor, mit dem eine systematische Bestandsaufnahme und Verbesserung lokaler Strukturen und Ressourcen der Gesundheitsförderung umgesetzt werden kann. Unsere Projekterfahrungen zeigen, dass sich das Vorgehen im Community Readiness-Modell gut umsetzen lässt. Wesentliche Vorteile dieses Ansatzes liegen in der Systematik des Vorgehens und in der lokalen Stärken- und Schwächenanalyse als Voraussetzung für kommunenspezifische Interventionen.
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Borucki, Isabelle, Lena Masch, and Simon Jakobs. "Grundsätzlich bereit, aber doch nicht dabei – Eine Analyse der Mitarbeitsbereitschaft in Parteien anhand des Civic Voluntarism Models." Zeitschrift für Politikwissenschaft 31, no. 1 (February 24, 2021): 25–56. http://dx.doi.org/10.1007/s41358-021-00251-w.

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ZusammenfassungWer sind die Menschen, die sich eine Parteimitgliedschaft vorstellen können, aber nicht beitreten? Mit den Datensätzen der Allgemeinen Bevölkerungsumfrage der Sozialwissenschaften (ALLBUS) der Jahre 2008 und 2018 liegen nunmehr größere, öffentliche und vor allem repräsentative Studien vor, die den Willen zu einer Parteiaktivität ermitteln. Mithilfe dieser Daten wird analysiert, inwieweit sozio-demografische Ressourcen, Motivation, Selbstwirksamkeit und die Einbindung in soziale Netzwerke mit dem Willen, aktiv in Parteien mitzuarbeiten, zusammenhängen. Logistische Regressionsmodelle zeigen nur einen geringen Einfluss soziodemographischer Faktoren. Allerdings sind politische Einstellungen wie beispielsweise das Vertrauen in Parteien relevant. Dies gilt vor allem für die ostdeutschen Bundesländer. Die Ergebnisse deuten darauf hin, dass das Civic Voluntarism Model neben einer Vielzahl von Beteiligungsformen auch – zumindest teilweise – dazu geeignet ist, eine beabsichtigte Parteiaktivität zu erklären.
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Monica, Mici Ara, and Yaswinda Yaswinda. "Analisis Implementasi Kurikulum 2013 PAUD di Masa Pandemi Covid-19 di Indonesia." Jurnal Basicedu 5, no. 2 (January 31, 2021): 643–53. http://dx.doi.org/10.31004/basicedu.v5i2.781.

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Penelitian ini bertujuan untuk menganalisa seberapa tinggi implementasi kurikulum 2013 PAUD. Penelitian ini menggunakan metode campuran (mix method researc). Subjek penelitian pada kuantitatif yaitu guru dengan jumlah 40 orang sedangkan subjek pada kualitatif yaitu 2 orang kepala sekolah dan 3 orang guru di Taman Kanak-kanak. Analisis data kuantitatif menggunakan deskriptif kuantitatif dengan menggunakan persentase sedangkan pada kualitatif menggunakan observasi, wawancara dan dokumentasi. Hasil penelitian diperoleh berdasarkan indikator kurikulum 2013 PAUD menunjukkan bahwa persentase rata-rata yang di peroleh sebesar 81, 96% sehingga tingkat capaian analisis implementasi kurikulum di Kecamatan Sungai Beremas dikategorikan tinggi. Hasil analisis kualitatif diperoleh bahwa pelaksanaan kurikulum dalam pembelajaran menggunakan model pembelajaran luring dan BDR disesuaikan saat penysusunan kurikulum dimasa pandemi covid-19. Kegiatan pembelajaran terlihat anak belajar tatap muka di rumah guru. Pada pelaksaanan pembelajaran RPPM dan RPPH yang digunakan disederhanakan seperti materi, metode, dan alokasi waktu yang di persingkat
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RETEGI ORMAZABAL, Josune. "Gestión del conocimiento en OSI Donostialdea-Osakidetza: retos y claves." RVGP 19, no. 19 (December 30, 2020): 112–27. http://dx.doi.org/10.47623/ivap-rvgp.19.2020.07.

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Laburpena: Artikulu honen helburua da Osakidetza - Donostialdea Erakunde Sanitario Integratuan Ezagutzaren Kudeaketaren eredua, hori lortzeko egindako bidea eta gaur egun arte lortutako emaitzak. Gaur egun bizi ditugunak bezalako aldaketa sakonak gertatzen diren uneetan diziplina horrek Administrazio Publikoan duen garrantziari buruzko hausnarketa batetik abiatzen gara. Jarraian, ezagutzaren kudeaketaren hedapenean bi elementuren garrantzia azaltzen da: erakundearen estrategia eta ezagutzen transferentzia esparru formal eta eraginkor batean. Azkenik, erakunde publikoetan ezagutzaren kudeaketaren hainbat erronka proposatzen dira: belaunaldien arteko erreleboa, ezagutzen konplexutasuna, antolaketa-ereduen aldaketak, herritarren esperientzia Administrazio Publikoaren erabakietan txertatzea eta hezkuntza-erakunde publikoaren arteko elkartasunak eta berrikuntza, besteak beste; era berean, ezagutza kudeatzeko eredu bat planteatzen da, Osakidetzako osasun-erakunde batean diseinatua eta hedatua, baita aurkeztutako praktikaren arrakasta-gakoak ere. Resumen: El propósito de este artículo es exponer el modelo de Gestión del Conocimiento en la Organización Sanitaria Integrada DONOSTIALDEA – OSAKIDETZA, el camino realizado para lograrlo y los resultados obtenidos hasta la actualidad. Partimos de una reflexión sobre la importancia de esta disciplina en la Administración Pública en momentos de cambios disruptivos como los que vivimos en la actualidad. A continuación, se expone la importancia de dos elementos en el despliegue de la gestión del conocimiento: la estrategia de la organización y la transferencia de conocimientos en un marco formal y eficaz. Finalmente, se proponen varios retos de la gestión del conocimiento en las organizaciones públicas: relevo generacional, complejidad de los conocimientos, cambios de modelos organizativos, incorporar la experiencia de la ciudadanía e innovación y alianzas educación-organización pública, entre otras; asimismo, se plantea un modelo de gestión del conocimiento, diseñado y desplegado en una organización sanitaria de OSAKIDETZA, así como las claves de éxito de la práctica presentada. Abstract: The purpose of this article is to present the Knowledge Management model in the Integrated Health Organization DONOSTIALDEA - OSAKIDETZA, the path taken to achieve it and the results obtained to date. We start from a reflection on the importance of this discipline in the Public Administration in times of disruptive changes such as those we are currently experiencing. Next, the importance of two elements in the deployment of knowledge management is explained: the organization's strategy and the transfer of knowledge in a formal and effective framework. Finally, several challenges of knowledge management in public organizations are proposed: generational change, complexity of knowledge, changes in organizational models, incorporation of citizens’ experience and innovation, and education-public organization alliances, among others; likewise, a knowledge management model is proposed, designed and deployed in an OSAKIDETZA healthcare organization, as well as the keys to success of the practice presented.
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Heinitz, Kathrin, and Jens Rowold. "Gütekriterien einer deutschen Adaptation des Transformational Leadership Inventory (TLI) von Podsakoff." Zeitschrift für Arbeits- und Organisationspsychologie A&O 51, no. 1 (January 2007): 1–15. http://dx.doi.org/10.1026/0932-4089.51.1.1.

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Zusammenfassung. Geprüft wurde, ob das Transformational Leadership Inventory (TLI; Podsakoff, MacKenzie & Bommer, 1996 ; Podsakoff, MacKenzie, Moorman & Fetter, 1990 ) mit sieben Inhaltsskalen zur Erfassung transformationaler und transaktionaler Führung für die Beurteilung deutscher Führungskräfte geeignet ist. In Testanalysen wurden die Gütekriterien der deutschen Adaptation anhand zweier Stichproben (N1 = 404, N2 = 267) ermittelt. Konfirmatorische Faktorenanalysen bestätigten das siebenfaktorielle Modell des TLI. Hohe Zusammenhänge zwischen den transformationalen Skalen und erstens subjektiven Zufriedenheits- und Leistungsmaßen sowie zweitens dem Commitment der Mitarbeiter werden als Belege für die Konstruktvalidität gewertet. Lediglich eine Skala des TLI erscheint aufgrund ihrer geringen internen Konsistenz als verbesserungswürdig. Insgesamt steht mit der hier vorgestellten deutschen Adaptation des TLI ein ökonomisches Instrument mit ansprechenden Gütekriterien für den Einsatz bereit. Bezogen auf die Konstrukt- und Kriterienvalidität des Instrumentes zeigen sich jedoch auch beim TLI vergleichbare Probleme wie etwa beim Multifactor Leadership Questionnaire.
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Bacchi, C. J., R. Brun, S. L. Croft, K. Alicea, and Y. Bühler. "In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors." Antimicrobial Agents and Chemotherapy 40, no. 6 (June 1996): 1448–53. http://dx.doi.org/10.1128/aac.40.6.1448.

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A series of novel aromatic derivatives based on the structure of methylglyoxal bis(guanylhydrazone) (MGBG) was examined for trypanocidal activities in human and veterinary trypanosomes of African origin. One agent, CGP 40215A, a bicyclic analog of MGBG which also resembles the diamidines diminazene (Berenil) and pentamidine, was curative of infections by 19 isolates of Trypanosoma brucei subspecies as well as a Trypanosoma congolense isolate. Several of these isolates were resistant to standard trypanocides. Curative doses were < or = 25 mg/kg of body weight/day for 3 days in these acute laboratory model infections. In addition, CGP 40215A also cured a model central nervous system infection in combination with the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine (DFMO; Ornidyl, eflornithine). Curative combinations were 14 days of oral 2% DFMO (approximately 5 g/kg/day) plus 5, 10, or 25 mg/kg/day for 3 or 7 days given by intraperitoneal injection or with a miniosmotic pump. Combinations were most effective if CGP 40215A was given in the second half or at the end of the DFMO regimen. MGBG has modest activity as an inhibitor of trypanosome S-adenosylmethionine decarboxylase (50% inhibitory concentration [IC50]. 130 microM), while CGP 40215A was a more active inhibitor (IC50, 20 microM). Preincubation of trypanosomes with CGP 40215A for 1 h caused a reduction in spermidine content (36%) and an increase in putrescine content (20%), indicating that one possible mechanism of its action may be inhibition of polyamine biosynthesis.
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Bruwer, P. J. S. "'n Behoeftebepalingsmetodologie vir die ontwerp van 'n bestuursinligtingstelsel in 'n bedryfsgerigte navorsingsonderneming." South African Journal of Business Management 24, no. 1 (March 31, 1993): 11–17. http://dx.doi.org/10.4102/sajbm.v24i1.857.

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A requirement determination methodology for designing a management information system for a professional research organization. Information as a strategic resource becomes increasingly more important for professionally managed organizations. The research was done in an organization where scientific management was seen as the main objective of the organization. As a result, the management information system had to be improved and developed in order to accommodate the different levels of management and to provide accurate and timely decision-making assisted information. A conceptual model was developed to assist the developers in improving the MIS in order to ensure that the correct information would reach the different levels of management, as well as to provide in the needs of external information users. Four levels of users were taken into account according to the pyramidial structure, as well as external and internal information needs for the successful implementation of the MIS.Inligting as 'n strategiese hulpbron word in 'n toenemende mate al hoe belangriker vir ondernemings wat professioneel - ooreenkomstig die wetenskaplike bestuursbeginsels - bestuur word. In die artikel word 'n onderneming wat wetenskaplike bestuur as hoofdoelwit aanvaar, ondersoek. As gevolg daarvan moes die bestuursinligtingstelsel so verbeter en ontwikkel word ten einde die verskillende vlakke van bestuur van akkurate en tydige besluitnemingsondersteunende inligting te voorsien. In hierdie navorsingsprojek is 'n konseptuele model ontwikkel om die ontwikkelaars van 'n verbeterde inligtingstelsel te voorsien sodat die regte inligting die verskillende vlakke van bestuur sal bereik, en ook om die eksterne inligtingsgebruikers se behoeftes te bevredig. Die model kyk na die inligtingsbehoeftes van die vier verskillende vlakke van gebruikers volgens die piramiedestruktuur asook na eksterne inligtingsbehoeftes en interne faktore wat in ag geneem moet word vir die suksesvolle implementering daarvan.
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BOIX PALOP, Andrés, and Alba SORIANO ARNANZ. "Sobre las posibilidades de reforma del modelo de empleo público español: límites constitucionales y jurídicos al modelo actual y sus sistemas de acceso." RVGP 20, no. 20 (June 30, 2021): 52–73. http://dx.doi.org/10.47623/ivap-rvgp.20.2021.03.

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Laburpena: Lan honetan, gure herrialdean enplegu publikoaren araubide juridikoa eta, zehazki, sarbide moten araubide juridikoa erorarazi dituzten gidalerro tradizional batzuk berrikustea komeni dela azaltzen da. Pilatutako eskarmentuak erakusten duenez, Espainiako gaurko sistemak zenbait arazo praktiko dauzka. Bada, arazo horiei erreparatuta eta eskarmentu konparatuan inspiratuta, hainbat irtenbide zehatz proposatzen dira hemen. Gure ustez, irtenbideok arazorik gabe bateratu daitezke Konstituzioak gai honetan dituen printzipioekin, eta enplegu publikoaren eredua oro har hobetzen lagunduko lukete; zehazki, enplegu publikora baldintza beretan sartzeko sistemei dagokienez. Hala nola: justifikazio objektiboa dagoenean bakarrik erreserbatzea funtzionarioei lanpostuak; probak aldatzea, gaitasunak erakusteari garrantzi handiagoa emateko; oposaketa tradizional askoren oztopo sozioekonomikoak ezabatuko dituzten BAME motako sistemak ezartzea eta, are, gizarteratzeko arazoak dituzten eta ingurune anitzagoetatik datozen taldeen artean edo praktika-programetatik abiatuta etorkizuneko langileak bilatzeko programekin esperimentatzea. Resumen: En este trabajo se expone la conveniencia de revisar algunas de las pautas tradicionales con las que se ha declinado en nuestro país el régimen jurídico del empleo público y, en particular, de los modos de acceso. A la luz de algunos de los problemas de tipo práctico que la experiencia acumulada muestra que presenta el actual sistema español, e inspirados en la experiencia comparada se proponen diversas soluciones concretas que, a nuestro juicio, serían perfectamente compatibles con los principios constitucionales en la materia y ayudarían a mejorar el modelo de empleo público en general y, específicamente, los sistemas de acceso a este en condiciones de igualdad: limitar la reserva a personal funcionario a puestos de trabajo donde haya una justificación objetiva para ellos, modificar las pruebas para dar más importancia a la demostración de capacidades, sistemas de tipo MIR que eliminen las barreras socioeconómicas de muchas oposiciones tradicionales e incluso la experimentación con programas de búsqueda de futuros y futuras trabajadoras entre grupos con problemas de inclusión y procedentes de entornos más diversos o a partir de programas de prácticas. Abstract: This paper reviews some of the traditional patterns of the Spanish legal framework applicable to public employment and, in particular, to its recruitment systems. In light of some of the practical problems our system presents and inspired by foreign experiences, we put forward a series of specific solutions which, in our opinion, would be perfectly compatible with the Spanish constitutional principles in this field and would help to improve the Spanish public employment system in general and, more specifically, recruitment under conditions of strict equality. These proposals include limiting civil servant positions to those for which there is an objective reason to be classified as such, increasing the weight given to the evaluation of qualitative skills in evaluation processes for access to public employment, MIR-type systems that eliminate some of the socio-economic barriers of traditional competitive examinations and even experimental programs or internship projects so as to enhance the chances of recruiting future public workers among groups with inclusion problems and from more diverse backgrounds.
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CARMONA GARIAS, Silvia. "La permanente renovación administrativa y la necesidad de regenerar la democracia: reinterpretación del panóptico a través del Open Government." RVAP 99-100, no. 99-100 (December 30, 2014): 821–44. http://dx.doi.org/10.47623/ivap-rvap.99.100.2014.033.

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LABURPENA: Administrazio publikoak etengabe modernizatu behar dira, herritarren premia berrietara moldatzeko. Demokrazia ordezkatzaile tradizionalaren eredua ez da nahikoa egungo panoraman, herritarrek protagonismo handiagoa eskatzen baitute. Zuzenbide konparatuak hainbat esperientzia berritzaile eskaintzen ditu. Besteak beste, eszenatoki politiko-administratiboan indar handiz sartu den gobernu irekia. Horixe da informazio-gizarteko administrazioan gertatu den modernizazioaren eboluzio logiko eta koherentea. Horregatik, azterlan honen ardatza da kontzeptuaren jatorria eta eboluzioa aztertzea, onurak eta arriskuak, Espainian orain arte zer egin den hartan subsumitzeko, eta zer gehiago egin behar den bide beretik aurreratzeko. RESUMEN: Las Administraciones publicas requieren llevar a cabo un proceso modernizador constante para adaptarse a las cambiantes necesidades ciudadanas. El modelo de democracia representativa tradicional no es suficiente en el panorama actual, en el que los ciudadanos reclaman mayor protagonismo. El Derecho comparado nos ofrece multiples experiencias innovadoras, entre ellas, la que ha irrumpido en el escenario politico-administrativo con mayor fuerza es el gobierno abierto. Este paradigma supone la evolucion logica y coherente de la modernizacion administrativa en la sociedad de la informacion, motivo por el que el presente estudio se centra en analizar el origen y evolucion del concepto, sus beneficios y sus riesgos, asi como que se ha hecho hasta ahora en Espana que pueda subsumirse en el mismo, y que mas se debe hacer para continuar avanzando en esa linea. ABSTRACT: Public administrations require to carry out a constant modernising process in order to adapt itself to the changing needs of citizenship. The model of traditional representative democracy is not sufficient in the present circumstances, where citizens claim for a larger prominence. Comparative Law offers us multiple innovative experiences, among them, the one that has bursted more strongly into the political administrative stage is open government. This paradigm means a logic and coherent evolution in administrative modernisation in the information society, that is why this study focuses itself on analyzing the origin and evolution of the concept, its benefits and risks together with what it has been done in Spain that can be subusmed within it, and what else should be done in order to advance in this line.
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Gereñu, Idoia. "Bazegonk amairu "jarrai" gabe?" Revista de lenguas y literaturas catalana, gallega y vasca 23 (December 17, 2018): 115. http://dx.doi.org/10.5944/rllcgv.vol.23.2018.23227.

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Jarrai antzerki-taldeak euskal antzerkigintzaren norabidea aldatu zuen ia hamar urteko ibilbidean, 60ko hamarkadan. Frankismo garaia betebetean zela, gazte-kuadrilla bat elkartu eta, gerraurreko ohiturei jarraiki, oholtza gainera igo zen, antzerkia aitzakiatzat hartuta. Xedea euskara zein euskal gizartea esnaraztea izan zen. Ordurako, belaunaldi berriek mundua ulertzeko bide berriak proposatu zituzten munduko zenbait herrialdeetan; mugimendu abangoardistak arte-diziplina anitzen bidez adierazi ziren, eta sentipen hau Euskal Herrira iritsi zen. Aitzina pausoak emateko gogoz, Jarrai antzerki-taldeak beste herrialdeetan eszenaratzen ari ziren abangoardiako antzerki-testuak euskarara ekarri zituen. Ildo beretik, euskaraz sortutako testuak ere eszenaratuko zituen aurrerago. Molde estetiko eta dramatiko berriak proposatzeaz gain, gazte euskaradun kulturazalearen irudi eta eredu bihurtu ziren Jarraikideak, beste diziplinei modernitaterako bidea erraztuz.The theater group Jarrai changed the direction of Basque theater in a nearly ten year career, in the 60s. During the Franco regime, aiming at reviving both the basque language and society, some young people gathered together on stage, following the tradition prior to the war. By that time, the new generations proposed in different countries of the world new ways of understanding it; the avant-garde movements were expressed in different artistic disciplines, and this feeling arrived in the Basque Country. The theater group Jarrai wanted to take some steps forward, and so translated into Basque some avant-garde theater texts that were staging in other countries. In this sense, they also staged some texts produced in Basque. In addition to proposing new aesthetic and dramatic molds, Jarrai became the image and model of the new basque young cultural movement, facilitating to other artistic disciplines the path towards modernization.
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Roberts, Sigrid C., Yuqui Jiang, Judith Gasteier, Benjamin Frydman, Laurence J. Marton, Olle Heby, and Buddy Ullman. "Leishmania donovani Polyamine Biosynthetic Enzyme Overproducers as Tools To Investigate the Mode of Action of Cytotoxic Polyamine Analogs." Antimicrobial Agents and Chemotherapy 51, no. 2 (February 2007): 438–45. http://dx.doi.org/10.1128/aac.01193-06.

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ABSTRACT A number of anticancer and antiparasitic drugs are postulated to target the polyamine biosynthetic pathway and polyamine function, but the exact mode of action of these compounds is still being elucidated. To establish whether polyamine analogs specifically target enzymes of the polyamine pathway, a model was developed using strains of the protozoan parasite Leishmania donovani that overproduce each of the polyamine biosynthetic enzymes. Promastigotes overexpressing episomal constructs encoding ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (ADOMETDC), or spermidine synthase (SPDSYN) revealed robust overproduction of the corresponding polyamine biosynthetic enzyme. Polyamine pools, however, were either unchanged or only marginally affected, implying that regulatory mechanisms must exist. The ODC, ADOMETDC, and SPDSYN overproducer strains exhibited a high level of resistance to difluoromethylornithine, 5′-{[(Z)-4-amino-2-butenyl]methylamino}-5′-deoxyadenosine, and n-butylamine, respectively, confirming previous observations that these agents specifically target polyamine enzymes. Conversely, augmented levels of polyamine biosynthetic enzymes did not affect the sensitivity of L. donovani promastigotes to pentamidine, berenil, and mitoguazone, drugs that were postulated to target the polyamine pathway, implying alternative and/or additional targets for these agents. The sensitivities of wild-type and overproducing parasites to a variety of polyamine analogs were also tested. The polyamine enzyme-overproducing lines offer a rapid cell-based screen for assessing whether synthetic polyamine analogs exert their mechanism of action predominantly on the polyamine biosynthetic pathway in L. donovani. Furthermore, the drug resistance engendered by the amplification of target genes and the overproduction of the encoded protein offers a general strategy for evaluating and developing therapeutic agents that target specific proteins in Leishmania.
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LEIVA LÓPEZ, Alejandro D. "La regulación del autoconsumo de electricidad en un nuevo entorno social y tecnológico." RVAP 110-I, no. 110-I (April 30, 2018): 117–55. http://dx.doi.org/10.47623/ivap-rvap.110.2018.1.04.

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LABURPENA: Elektrizitatea energia berriztagarrien iturrietatik (adibidez, fotovoltaikotik) autokontsumitzen bada, maila askotan egiten zaie on sistema elektrikoari, planetari eta kontsumitzaileari. Sorkuntza banatuaren modalitate horrek abantailak sorrarazten ditu ingurumenean (karbono-gabetzeari laguntzen baitio), herrialdeko ekonomian (negozio-eredu berriak bultzatzen baititu), sistema elektrikoan oro har (garraioan gertatzen diren galerak murrizten baititu) eta, batez ere, azken kontsumitzailearengan (aurrezpenaz gain, energia-kudeaketaren kontrolari laguntzen baitio). Horrela, bada, elektrizitatea sortzeko eredu horrek duen garrantziarengatik, autokontsumoan eta ingurune sozial eta teknologiko berrian oinarritzen baita, lan sistematiko bat egin dugu, non elektrizitatearen autokontsumo-eredu ezberdinen legezko erregulazioa aztertzen den (900/2015 Errege Dekretuan zehazten dira eredu horiek). Era berean, are zorrotzagoak izate aldera, egoki ikusi dugu gaur arte egon diren eskumen-arloko gatazkei buruzko azken doktrina-erabakiak aztertzea; batez ere, autokontsumo partekatuaren arlokoak. RESUMEN: El autoconsumo de electricidad a través de fuentes de energía renovable, como la fotovoltaica, constituye una alternativa que favorece al sistema eléctrico, al planeta y al consumidor a muchos niveles. Esta modalidad de generación distribuida proporciona ventajas en el medio ambiente —por su contribución a la descarbonización—, en la economía del país —favoreciendo nuevos modelos de negocio—, en el sistema eléctrico en su conjunto —ya que contribuye a la reducción de pérdidas en el transporte— y, sobre todo, para el consumidor final —favoreciendo no solo al ahorro, sino también al control de la gestión energética—. Así, por la importancia de este modelo de generación de electricidad con autoconsumo en un nuevo entorno social y tecnológico, hemos elaborado un trabajo sistemático que analiza la regulación legal de las distintas figuras de autoconsumo de electricidad definidas en el Real Decreto 900/2015. Asimismo, y para una mayor exhaustividad y rigor, hemos considerado conveniente analizar los más recientes pronunciamientos doctrinales acerca de los conflictos competenciales acontecidos hasta la fecha y, destacadamente, en materia de autoconsumo compartido. ABSTRACT: The electricity self-consumption through renewable energy sources, such as photovoltaic power, is an alternative that favors the electricity system, the planet and the consumer at very many levels. This type of distributed generation provides advantages in the environment —with regard to the decarbonization—, in the country’s economy —favoring new business models—, in the electricity system —with regard to the reduction of electricity losses in transport— and, above all, for the final consumer —promoting not only energy savings, but also energy management—. In this way, due to the importance of this electricity self consumption model, we have elaborated a systematic research work that analyzes the legal regulation of the different electricity self-consumption figures defined in the Royal Decree 900/2015. As well, we have considered the opportunity to analyze the most recent doctrinal pronouncements about the potential conflicts over areas of competence occurred at the time and, in particular, the advances in terms of shared self-consumption.
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49

GALDEANO LARIZGOITIA, Iñaki, and Sebastián ZURUTUZA MUJIKA. "Financiación de las entidades locales de Euskadi en el marcode la Ley 2/2016, de Instituciones Locales de Euskadi." Revista Vasca de Administración Pública / Herri-Arduralaritzarako Euskal Aldizkaria, no. 107-II (April 28, 2017): 471–501. http://dx.doi.org/10.47623/ivap-rvap.107.2017.2.12.

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LABURPENA: Euskadiko Toki Erakundeei buruzko 2/2016 Legearekin batera Euskal Autonomia Erkidegoko barne instituzionalizazio-prozesua bukatu da, erakundeen beste bi mailekin (foru maila eta erkidego maila) modu harmonikoan egituratu behar den toki-gobernu eredua artikulatuz. Legeak toki-autonomiaren funtsezko bi alderdiak uztartzen ditu: eskumenak eta finantzaketa. Nolanahi ere, foru-erakundeek arlo honetan ekarpen garrantzitsuak egin ditzakete. Legeak izaera integrala dauka, eskumen sistema propio eta berezia osatzea eragingo duena; ezin da finantzaketatik banandu. Finantzaketa nahikoa eta autonomia izatea, finantza-iraunkortasuna eta aurrekontu-egonkortasuna dira Euskadiko Toki Erakundeei buruzko Legeak bermatu nahi dituen toki-ogasunen oinarrizko jarduketa-printzipioen osagaiak. Finantzaketa egokiaren bermea eskumen propioetan zein EAEko udalerriek baliatu dituzten beste eskumen batzuetan proiektatu da —legez edo foru-arauz eman ahal zaizkien eskumen berriak barne— baita transferitu edo eskuordetu daitezkeen eskumenetan ere. Toki-finantzaketaren arloan Euskadiko Toki Erakundeei buruzko Legetik eratorritako sistema instituzionala, oro har, Finantza Publikoen Euskal Kontseiluko erabakiak hartzean udal-ordezkariek daukaten parte hartzeak definitzen du. Horri dagokionez, Lurralde Historikoen Legea aldatzearen ondorioz, toki-finantzaketarako oso garrantzitsuak diren arlo askotako erabakiak hartzean udal-ordezkariak gehituko dira, eskubide osoko kide gisa (ahotsa eta botoa), dualtzat har daitekeen parte-hartze instituzionaleko eredu baten barruan. Eredu horren arabera gaiak banatu egiten dira: batetik, hiru maila instituzionalen parte hartzea behar duten akordioak, eta, bestetik, garrantzitsuak izanik soilik foru eta udal mailakoei dagozkienak (parte-hartze maila edo eredu horizontala ekarpenen legeetan). RESUMEN: La Ley 2/2016 de Instituciones Locales de Euskadi (LILE) culmina el proceso de institucionalización interna de la Comunidad Autónoma de Euskadi articulando un modelo de gobierno local que debe vertebrarse de manera armónica con los otros dos niveles dos niveles institucionales (foral y autonómico). Es una ley que, sin perjuicio de las importantes atribuciones que en este ámbito tienen las instituciones forales, integra los dos aspectos sustantivos de la autonomía local: competencias y financiación. Carácter integral que va a determinar la configuración de un sistema competencial propio y singular que no puede disociarse de su financiación. La suficiencia y autonomía financiera, junto con la estabilidad presupuestaria y la sostenibilidad financiera, constituyen los principios de actuación básicos de las haciendas locales que la LILE trata de garantizar. La garantía de financiación adecuada se proyecta tanto sobre las competencias propias que vienen ejerciendo los municipios vascos como sobre las nuevas competencias que les puedan ser atribuidas por ley o norma foral o que les puedan ser transferidas o delegadas. El sistema institucional, en materia de financiación local, que se deriva de la LILE, viene definido fundamentalmente por el modelo de participación de los re presentantes municipales en la toma de decisiones del Consejo Vasco de Finanzas Públicas. A este respecto, con la consiguiente modificación de la Ley de Territorios Históricos, se incorporan los representantes municipales, como miembros de pleno derecho (voz y voto) en la toma de decisiones acerca de un significativo número de materias de gran trascendencia para la financiación local, dentro de un modelo de participación institucional que podemos calificar de dual. Modelo conforme al cual se diferencia entre aquellas materias cuyos acuerdos precisan de la participación de los tres niveles institucionales y aquellas otras, de especial importancia (nivel de participación o modelo horizontal en leyes de aportaciones), cuyos acuerdos solamente competen a los niveles foral y municipal. ABSTRACT: Act 2/2016 on Local Entities of Euskadi (LILE) brings to an end the process of internal institutionalization of the Autonomous Community of Euskadi by articulating a local government model that has harmoniously to be built upon the other two levels of institutions (foral and autonomous). It is an act that, with no prejudice to the important attributions foral institutions have in this area, comprehends two substantive features of local autonomy: competences and funding. That comprehensive character is going to determine the configuration of an own and singular system of competences which cannot be dissociated from its funding. The financial sufficiency and autonomy, together with the budgetary stability are the basic principles of action of local government finances that LILE tries to guarantee. The guarantee for an adequate funding is projected both to own competences that Basque municipalities are already exercising and to new competences that can be attributed either by act or by foral rule or that can be transferred or delegated. The institutional system, in the field of local funding, that results from LILE is mainly defined by the model of participation by the municipal representatives in the decision-making process of the Basque Committee for Public Finances. In this regard, with the consequential amendment of the Act on Historic Territories, the municipal representatives will be incorporated as full members (with voice and vote) in the decision-making process in a significant amount of very important issues for the local funding within the model of institutional participation which can be qualified as twofold. A model according to whom those issues whose agreement requires the participation of the three institutional levels and those others, with particular relevance (level of participation or horizontal model in act of contributions) whose agreement does only affect the foral and municipal levels.
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50

GONZÁLEZ RÍOS, Isabel. "La incipiente regulación del autoconsumo de energía eléctrica: implicaciones energéticas, ambientales y urbanísticas." RVAP 99-100, no. 99-100 (December 30, 2014): 1661–87. http://dx.doi.org/10.47623/ivap-rvap.99.100.2014.068.

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LABURPENA: Sektore Elektrikoaren Legearen 9. artikuluak autokontsumo elektrikoa arautzeko duen modu berritzailea aztertzen du lan honek, eta hori garatzeko aukera ematen duten egungo erregelamendu-arauekin lotzen du hori, gaia garatzeko iragarritako erregelamendua onartu bitartean. Agerian uzten du lotura berezia dagoela elektrizitatea sortzeko/kontsumitzeko eredu honen eta energia berriztagarrien erabileraren artean, Europar Batasuneko araudiak xedatutakoaren esparruan. Bereziki aztertzen da autokontsumoari ezartzen zaion araubide ekonomiko polemikoa, «laguntza-bidesaria» delakoa ordaintzeko beharrarekin. Bestalde, energiaren eta lehiaren arautzaile nazionalak, egun Merkatuen eta Lehiaren Batzorde Nazionala denak, horren kontra ezarritako doktrina ere azaltzen da. Bukatzeko, autokontsumo elektrikoan eragiten duten inplikazio energetikoak, ingurumenekoak eta hirigintzakoak ere azaltzen ditugu, eta hori ezartzen eta garatzen lagunduko duten araudi integratuko proposamen batzuk aipatzen. RESUMEN: Este estudio analiza la novedosa regulación del autoconsumo eléctrico que realiza el art. 9 de la Ley del Sector Eléctrico, poniéndola en relación con la actual regulación reglamentaria que permite su desarrollo, a la espera de la aprobación del anunciado reglamento de desarrollo de la materia. Se muestra la especial vinculación entre este modelo de generación/consumo eléctrico y la utilización de fuentes de energías renovables, en el marco de lo dispuesto en la normativa de la Unión Europea. Especial atención se presta al controvertido régimen económico a que se sujeta el autoconsumo, con el pago del llamado «peaje de respaldo»; y la doctrina contraria al mismo sentada por el regulador nacional de la energía y de la competencia, hoy Comisión Nacional de Mercados y de la Competencia. Para concluir exponemos las implicaciones energéticas, ambientales y urbanísticas que inciden en el autoconsumo eléctrico, con referencia a algunas propuestas de regulación integrada de la materia que permitan fomentar su implantación y desarrollo. ABSTRACT: This study analyzes the new regulation about the electric self-supply set forth by article 9 of the Electric sector Act linking it to the current regulatory regulation which allows its implementation, waiting to the passing of the announced implementing regulation of the subject. It shows the special correlation between this model of electric supply and the use of sources of renewable energies in the framework of the normative set by the European Union. Special attention is given to the controversial economic regime to which self supply is bound, with the payment of the back up toll; and the doctrine opposed to it established by the national regulator of energy and competition. To conclude we show the energy, enviromental and urban implications that have an impact over the electric self supply with reference to some proposals for an integrated regulation in this area that allow the promotion of its introduction and development.
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