Log in

Relevant bibliographies by topics / Bern Trial / Journal articles

To see the other types of publications on this topic, follow the link: Bern Trial.

Journal articles on the topic 'Bern Trial'

Author: Grafiati

Published: 28 July 2024

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Bern Trial.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Leddin, Desmond. "Alpha Errors, Beta Errors and Negative Trials." Canadian Journal of Gastroenterology 2, no. 4 (1988): 147–50. http://dx.doi.org/10.1155/1988/523841.

Full text

Abstract:

Reports of negative trials arc increasing in number as standard therapy for many gastrointestinal diseases is refined. The validity of a negative report depends on the number of patients in the trial, the alpha and bern error and the difference in efficacy which the trial is able to detect. The relationship between these parameters is discussed and a formula given for the calculation of trial size. All reports of negative trials should include not only the number of patients involved and the level of significance of the results but also the beta error and the detectable difference in efficacy

APA, Harvard, Vancouver, ISO, and other styles

2

Riedel, Robert G. "Effects of Pretrial Publicity on Male and Female Jurors and Judges in a Mock Rape Trial." Psychological Reports 73, no. 3_part_1 (1993): 819–32. http://dx.doi.org/10.1177/00332941930733pt117.

Full text

Abstract:

A study explored influence of pretrial publicity and gender identity on verdicts and severity of sentence in a mock rape trial. Mock jurors and judges were exposed to four pretrial publicity conditions before watching a simulated rape trial. After viewing the trial, jurors rendered a verdict (guilty or not guilty) and judges prescribed a sentence. The Bern Sex-role Inventory was used to analyze gender identity and its relation to verdict and sentencing. Verdicts were not influenced by pretrial publicity, but sentencing was more severe following exposure of mock judges to pretrial publicity abo

APA, Harvard, Vancouver, ISO, and other styles

3

Hari, Roman, Kaspar Kälin, Michael Harris, Robin Walter, and Andreas Serra. "Comparing Blended Learning with Faculty-Led Ultrasound Training: Protocol for a Randomised Controlled Trial (The SIGNATURE Trial)." Praxis 109, no. 8 (2020): 636–40. http://dx.doi.org/10.1024/1661-8157/a003497.

Full text

Abstract:

Abstract. Background: Ultrasound is increasingly used in clinical practice as a bedside tool. As medical graduates first encounter the technique in early residency, ultrasound training needs to be integrated into the undergraduate curriculum. In Switzerland, abdominal ultrasound skills have been taught by a faculty-led, 21-hour course. However, this course does not have sufficient capacity to meet the increasing demand, and there have been doubts about its effectiveness as a teaching method. We therefore developed a 21-hour blended-learning course, comprising five hours of e-learning and 16 ho

APA, Harvard, Vancouver, ISO, and other styles

4

Beilstein, Christian M., Gabija Krutkyte, Thomas Vetsch, et al. "Multimodal prehabilitation for major surgery in elderly patients to lower complications: protocol of a randomised, prospective, multicentre, multidisciplinary trial (PREHABIL Trial)." BMJ Open 13, no. 1 (2023): e070253. http://dx.doi.org/10.1136/bmjopen-2022-070253.

Full text

Abstract:

IntroductionThe global volume of surgery is growing and the population ageing, and economic pressure is rising. Major surgery is associated with relevant morbidity and mortality. Postoperative reduction in physiological and functional capacity is especially marked in the elderly, multimorbid patient with low fitness level, sarcopenia and malnutrition. Interventions aiming to optimise the patient prior to surgery (prehabilitation) may reduce postoperative complications and consequently reduce health costs.Methods and analysisThis is a multicentre, multidisciplinary, prospective, 2-arm parallel-

APA, Harvard, Vancouver, ISO, and other styles

5

Amrein, Melanie Alexandra, Gian Giacomo Ruschetti, Carole Baeder, Melanie Bamert, and Jennifer Inauen. "Mobile intervention to promote correct hand hygiene at key times to prevent COVID-19 in the Swiss adult general population: study protocol of a multiphase optimisation strategy." BMJ Open 12, no. 3 (2022): e055971. http://dx.doi.org/10.1136/bmjopen-2021-055971.

Full text

Abstract:

IntroductionBehaviour change is key to the public health measures that have been issued in many countries worldwide to contain COVID-19. Public health measures will only take preventive effect if people adhere to them. Interventions taking health psychology approaches may promote adherence to public health measures. However, evidence from randomised controlled behaviour change trials is scarce during an ongoing pandemic. We aim to use the example of hand washing with soap to optimise and test a digital, theory-based and evidence-based behaviour change intervention to prevent the spread of COVI

APA, Harvard, Vancouver, ISO, and other styles

6

Zwahlen, Susanne, Monica Fliedner, and Steffen Eychmüller. "Overcoming recruitment challenges in a randomized clinical trial of early palliative care." Journal of Clinical Oncology 35, no. 31_suppl (2017): 140. http://dx.doi.org/10.1200/jco.2017.35.31_suppl.140.

Full text

Abstract:

140 Background: Reasons why clinical trials of early palliative care (ePC) interventions have prolonged patient recruitment time frames have been researched mainly qualitatively. Our objective was to identify major recruitment barriers encountered in our ePC trial, as well as to implement actions to overcome them. The impact of these changes on recruitment was measured. Methods: Data from all patients screened at the main study site (Inselspital, University Hospital Bern) between October 2013 and April 2016 were prospectively analyzed for: date of contact, reporting department, eligibility sta

APA, Harvard, Vancouver, ISO, and other styles

7

Theis, Susanne, Norman Bitterlich, Michael von Wolff, and Petra Stute. "Measuring Quality of Life: Incorporating Objectively Measurable Parameters within the Cross-Sectional Bern Cohort Study 2014 (BeCS-14)." International Journal of Environmental Research and Public Health 21, no. 1 (2024): 94. http://dx.doi.org/10.3390/ijerph21010094.

Full text

Abstract:

Up until now, the measurement of Quality of Life (QoL) was based on validated subjective rating tools rather than objective measurement. To become more independent of the self-assessment of probands, a way to objectively measure QoL should be found. A monocenter, cross-sectional, observational, non-interventional trial was performed from 2012 to 2014 at Inselspital Bern to evaluate the bio-functional status (BFS), a complex, generic, non-invasive, sex- and age-validated assessment tool, in a wide range of areas. A standardized battery of assessments was performed on 464 females and 166 males,

APA, Harvard, Vancouver, ISO, and other styles

8

Liechti, Fabian D., Jeannelle Heinzmann, Joachim M. Schmidt Leuenberger, Andreas Limacher, Maria M. Wertli, and Martin L. Verra. "Effect of goal-directed mobilisation intervention compared with standard care on physical activity among medical inpatients: protocol for the GoMob-in randomised controlled trial." BMJ Open 12, no. 5 (2022): e058509. http://dx.doi.org/10.1136/bmjopen-2021-058509.

Full text

Abstract:

IntroductionDespite the fact that immobilisation is a major contributor to morbidity and mortality, patients hospitalised in general internal medicine (GIM) wards spend up to 50% of time in bed. Previous studies in selected patient populations showed increased mobility after implementation of goal-directed mobilisation (GDM). Due to the study design used so far, the degree of evidence is generally low. The effect of GDM on clinical outcomes and economically relevant indicators in patients hospitalised in GIM wards is currently unknown. This study aims to evaluate a GDM intervention compared to

APA, Harvard, Vancouver, ISO, and other styles

9

Adam, Luise, Elisavet Moutzouri, Christine Baumgartner, et al. "Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial." BMJ Open 9, no. 6 (2019): e026769. http://dx.doi.org/10.1136/bmjopen-2018-026769.

Full text

Abstract:

Introduction Multimorbidity and polypharmacy are important risk factors for drug-related hospital admissions (DRAs). DRAs are often linked to prescribing problems (overprescribing and underprescribing), as well as non-adherence with drug regimens for different reasons. In this trial, we aim to assess whether a structured medication review compared with standard care can reduce DRAs in multimorbid older patients with polypharmacy. Methods and analysis OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people is a European multicentre, cluster randomised, controlled

APA, Harvard, Vancouver, ISO, and other styles

10

Wertli, Maria M., Julian S. Flury, Sven Streit, et al. "Efficacy of metamizole versus ibuprofen and a short educational intervention versus standard care in acute and subacute low back pain: a study protocol of a randomised, multicentre, factorial trial (EMISI trial)." BMJ Open 11, no. 10 (2021): e048531. http://dx.doi.org/10.1136/bmjopen-2020-048531.

Full text

Abstract:

IntroductionLow back pain (LBP) is among the top three most common diseases worldwide, resulting in a life with pain-related disability. To date, no study has assessed the efficacy of metamizole (dipyrone), a non-opioid analgesic and antipyretic prodrug compared with the conventional non-steroidal anti-inflammatory drug ibuprofen, in patients with an acute LBP episode. Further, it is unclear, whether a short educational intervention is superior to usual care alone.ObjectivesThe objective of this study is to assess first, whether metamizole is non-inferior to ibuprofen in a new episode of acute

APA, Harvard, Vancouver, ISO, and other styles

11

Mathier, Etienne, Alexander Althaus, Daniel Zwahlen, et al. "HypoFocal SRT Trial: Ultra-hypofractionated focal salvage radiotherapy for isolated prostate bed recurrence after radical prostatectomy; single-arm phase II study; clinical trial protocol." BMJ Open 14, no. 1 (2024): e075846. http://dx.doi.org/10.1136/bmjopen-2023-075846.

Full text

Abstract:

IntroductionDespite radical prostatectomy (RP) and radiotherapy (RT) being established treatments for localised prostate cancer, a significant number of patients experience recurrent disease. While conventionally fractionated RT is still being used as a standard treatment in the postoperative setting, ultra-hypofractionated RT has emerged as a viable option with encouraging results in patients with localised disease in the primary setting. In addition, recent technological advancements in RT delivery and precise definition of isolated macroscopic recurrence within the prostate bed using prosta

APA, Harvard, Vancouver, ISO, and other styles

12

Jungo, Katharina Tabea, Zsofia Rozsnyai, Sophie Mantelli, et al. "‘Optimising PharmacoTherapy In the multimorbid elderly in primary CAre’ (OPTICA) to improve medication appropriateness: study protocol of a cluster randomised controlled trial." BMJ Open 9, no. 9 (2019): e031080. http://dx.doi.org/10.1136/bmjopen-2019-031080.

Full text

Abstract:

IntroductionMultimorbidity and polypharmacy are major risk factors for potentially inappropriate prescribing (eg, overprescribing and underprescribing), and systematic medication reviews are complex and time consuming. In this trial, the investigators aim to determine if a systematic software-based medication review improves medication appropriateness more than standard care in older, multimorbid patients with polypharmacy.Methods and analysisOptimising PharmacoTherapy In the multimorbid elderly in primary CAre is a cluster randomised controlled trial that will include outpatients from the Swi

APA, Harvard, Vancouver, ISO, and other styles

13

Schurz, Alexander Philipp, Tom Deliens, Melanie Liechti, et al. "Economic evaluation of a lifestyle intervention for individuals with overweight or obesity suffering from chronic low back pain (the BO2WL trial): a protocol for a health economic analysis." BMJ Open 15, no. 6 (2025): e098272. https://doi.org/10.1136/bmjopen-2024-098272.

Full text

Abstract:

IntroductionLow back pain (LBP) is highly prevalent across the Western world, including Switzerland (CH) and Belgium (BE), with women experiencing higher disability rates than men. Chronic LBP (CLBP), persisting beyond 3 months, leads to diminished health-related quality of life and increased healthcare and societal costs. Evidence indicates a direct relationship between body mass index (BMI) and CLBP severity, with high BMI significantly driving LBP-related healthcare expenses. Current evidence supports combining pain neuroscience education (PNE) with cognition-targeted exercise therapy (CTET

APA, Harvard, Vancouver, ISO, and other styles

14

Arifi, Deborah, Norman Bitterlich, Michael von Wolff, Dagmar Poethig, and Petra Stute. "Impact of chronic stress exposure on cognitive performance incorporating the active and healthy aging (AHA) concept within the cross-sectional Bern Cohort Study 2014 (BeCS-14)." Archives of Gynecology and Obstetrics 305, no. 4 (2021): 1021–32. http://dx.doi.org/10.1007/s00404-021-06289-z.

Full text

Abstract:

Abstract Purpose This study aims to verify that the mental-cognitive domain of the validated generic bio-functional status (BFS)/bio-functional age (BFA) assessment tool, incorporating the concept of Active and Healthy Ageing (AHA), reflects cognitive performance. In addition, the effects of chronic stress exposure on the mental-cognitive BFS/BFA should be investigated. Methods The study was carried out as a monocenter, cross-sectional, observational, non-interventional trial (Bern Cohort Study 2014, BeCS-14) with the participation of 147 non-pediatric, non-geriatric subjects. All participants

APA, Harvard, Vancouver, ISO, and other styles

15

Scoglio, Martin, Matteo Bargagli, Felix Rintelen, Marie Roumet, Sven Trelle, and Daniel G. Fuster. "Indapamide or chlorthalidone to reduce urine supersaturation for secondary prevention of kidney stones: protocol for a randomised, double-blind, cross-over trial (INDAPACHLOR)." BMJ Open 15, no. 6 (2025): e101594. https://doi.org/10.1136/bmjopen-2025-101594.

Full text

Abstract:

IntroductionKidney stones constitute a major global healthcare problem and are characterised by high recurrence rates. Thiazide and thiazide-like diuretics (thiazides) have been the standard medical treatment for the prevention of kidney stone recurrence. This clinical routine has recently been challenged by the findings of the large NOSTONE trial that failed to show superiority of hydrochlorothiazide at doses up to 50 mg daily over placebo in preventing a composite of clinical or radiological recurrence in patients at high risk of kidney stone recurrence. If these results also apply to the lo

APA, Harvard, Vancouver, ISO, and other styles

16

Miloradova, N. E. "Scenario tendencies of professional genesis of investigators of pre-trial investigation agencies of the National police of Ukraine." Law and Safety 76, no. 1 (2020): 153–51. http://dx.doi.org/10.32631/pb.2020.1.22.

Full text

Abstract:

The author of the article has presented results of a thorough analysis of international (A. Adler, E. Bern, R. Brasington, T. Keller, C. Toich, S.B. Karpman, K. Steiner, etc.) and domestic (K. O. Abulkhanova-Slavska, O. O. Bodalov, Ye. I. Holovakha, E. F. Zeier, Ye. O. Klimov, N. S. Priazhnikova, Ye. Yu. Priazhnikov, S. L. Rubinshtein, E. E. Symaniuk, etc.) approaches to consider specific features of professional development of individuals and formation of scenario tendencies for self-deployment within personal and professional fields. Based on the analysis of the works of the mentioned

APA, Harvard, Vancouver, ISO, and other styles

17

Pimentel, Leonardo Duarte, Claudio Horst Bruckner, Candida Elisa Manfio, Sérgio Yoshimitsu Motoike, and Hermínia Emília Prieto Martinez. "SUBSTRATE, LIME, PHOSPHORUS AND TOPDRESS FERTILIZATION IN MACAW PALM SEEDLING PRODUCTION." Revista Árvore 40, no. 2 (2016): 235–44. http://dx.doi.org/10.1590/0100-67622016000200006.

Full text

Abstract:

ABSTRACT The macaw palm [Acrocomia aculeata (Jacq.) Lood. ex Mart] has been domesticated to subsidize biodiesel production programs in Brazil. However, little is known about the seedling production of this species. This study aimed to evaluate substrate mixtures, limestone and phosphorus rates for substrate amendment and topdressing frequency in macaw palm seedlings. Three trials were conducted in a greenhouse up to six months of nursery cultivation. Trial 1: determination of percent mineral and organic fractions of seven substrate mixtures. Trial 2: evaluation of four limerates for soil amend

APA, Harvard, Vancouver, ISO, and other styles

18

Klukowska-Röetzler, Jolanta, Maria Eracleous, Martin Müller, et al. "Increased Urgent Care Center Visits by Southeast European Migrants: A Retrospective, Controlled Trial from Switzerland." International Journal of Environmental Research and Public Health 15, no. 9 (2018): 1857. http://dx.doi.org/10.3390/ijerph15091857.

Full text

Abstract:

We investigated whether immigrants from Southeast Europe (SE) and Swiss patients have different reasons for visiting the emergency department (ED). Our retrospective data analysis for the years 2013–2017 describes the pattern of ED consultations for immigrants from SE living in Switzerland (Canton Bern), in comparison with Swiss nationals, with a focus on type of referral and reason for admission. A total of 153,320 Swiss citizens and 12,852 immigrants from SE were included in the study. The mean age was 51.30 (SD = 21.13) years for the Swiss patients and 39.70 (SD = 15.87) years for the SE pa

APA, Harvard, Vancouver, ISO, and other styles

19

Theiler, Lorenz, Fabian Schneeberg, Thomas Riedel, Heiko Kaiser, Thomas Riva, and Robert Greif. "Apnoeic oxygenation with nasal cannula oxygen at different flow rates in anaesthetised patients: a study protocol for a non-inferiority randomised controlled trial." BMJ Open 9, no. 7 (2019): e025442. http://dx.doi.org/10.1136/bmjopen-2018-025442.

Full text

Abstract:

IntroductionApnoeic oxygenation using nasal high-flow oxygen delivery systems with heated and humidified oxygen has recently gained popularity in the anaesthesia community. It has been shown to allow a prolonged apnoea time of up to 65 min as CO2increase was far slower compared with previously reported data from CO2increase during apnoea. A ventilatory exchange due to the high nasal oxygen flow was proposed explaining that phenomenon. However, recent studies in children did not show any difference in CO2clearance comparing high-flow with low-flow oxygen. To investigate this ventilatory exchang

APA, Harvard, Vancouver, ISO, and other styles

20

Gennheimer, Valérie, Dilara Akhoundova, Michèle Hoffmann, et al. "Adherence to Multidisciplinary Tumor Board Recommendations in Patients with Multiple Myeloma." Cancers 17, no. 8 (2025): 1297. https://doi.org/10.3390/cancers17081297.

Full text

Abstract:

Background: Patient management following a multidisciplinary tumor board (MTB) recommendation has become standard of care in oncology and aims to ensure optimization and personalization of patient care. To assess the impact of MTB recommendations in clinical practice, adherence to the recommended procedures needs to be evaluated. Within this retrospective case series, we examined adherence rates to recommendations formulated at multidisciplinary myeloma tumor boards (MMTB) held at our institution. Specifically, we analyzed how often recommendations involving diagnostic procedures, therapies, a

APA, Harvard, Vancouver, ISO, and other styles

21

Uslu, Arif Sinan, Stephan M. Gerber, Nadine Schmidt, et al. "Investigating a new tablet-based telerehabilitation app in patients with aphasia: a randomised, controlled, evaluator-blinded, multicentre trial protocol." BMJ Open 10, no. 11 (2020): e037702. http://dx.doi.org/10.1136/bmjopen-2020-037702.

Full text

Abstract:

IntroductionAphasia is a common language disorder acquired after stroke that reduces the quality of life of affected patients. The impairment is frequently accompanied by a deficit in cognitive functions. The state-of-the-art therapy is speech and language therapy but recent findings highlight positive effects of high-frequency therapy. Telerehabilitation has the potential to enable high-frequency therapy for patients at home. This study investigates the effects of high-frequency telerehabilitation speech and language therapy (teleSLT) on language functions in outpatients with aphasia compared

APA, Harvard, Vancouver, ISO, and other styles

22

Stawarska-Rippel, Anna. "Kontradyktoryjność i inkwizycyjność w europejskiej procedurze cywilnej XIX i XX wieku." Czasopismo Prawno-Historyczne 65, no. 2 (2018): 123–44. http://dx.doi.org/10.14746/cph.2013.65.2.05.

Full text

Abstract:

Socialisation of private law in the second half of the 19th century brought about a new approach to a civil process and its purpose. The main characteristics of the evolution of the civil procedure in the 19th and 20th centuries was limited autonomy of the parties to a process. This limitation was introduced to ensure fair, expedient and cost-effective judgment. A tendency to replace the principle of an adversarial trial with elements of an inquisitorial trial was observed in civil law as well as common law systems. Relevant changes were fi rst made in the Franz Klein Austrian code of civil pr

APA, Harvard, Vancouver, ISO, and other styles

23

Kiosak, Dmytro, and Zhanna Matviishyna. "The Soils of Early Farmers and Their Neighbors in the Southern Buh Catchment (Ukraine): Micromorphology and Archaeological Context." Land 12, no. 2 (2023): 388. http://dx.doi.org/10.3390/land12020388.

Full text

Abstract:

The problems regarding hunter-gatherer/early farmer interactions are quite an important topic in southeast European archaeology. According to the available data, the two economic subsistence systems have coexisted for some 2000 years during the 6th–4th millennia cal BC (Telegin 1985; Lillie et al., 2001). In some areas, hunter-gatherer and early farmer sites are located just a few kilometers apart. The Southern Buh River valley has yielded evidence of Linear Pottery culture, early Trypillia and Trypillia B1 Neolithic settlements as well as hunter-gatherer sites with pottery attributable to the

APA, Harvard, Vancouver, ISO, and other styles

24

Miklas, Phillip N., and Jose Santiago. "Reaction of Select Tepary Bean to Bean Golden Mosaic Virus." HortScience 31, no. 3 (1996): 430–32. http://dx.doi.org/10.21273/hortsci.31.3.430.

Full text

Abstract:

Cultivated tepary bean (Phaseolus acutifolius A. Gray var. latifolius Freeman) has potential for production during the hot, dry seasons in the tropics. Bean golden mosaic virus (BGMV), however, seriously limits production of Phaseolus spp. in such environments. Twelve select tepary beans were evaluated for reaction to BGMV across four field nurseries near Isabela, Puerto Rico. Disease reaction was principally determined by measurement of seed yield (kg·ha–1) and weight (g 100/seeds). All tepary beans possessed some tolerance to BGMV, as they produced comparatively moderate seed yield despite e

APA, Harvard, Vancouver, ISO, and other styles

25

Phuong, Tran Vinh, Nguyen Anh Tuan, Nguyen Duy Thuan, et al. "Effects of protein levels of commercial diets on the growth performance and survival rate of rabbitfish (Siganus guttatus) at the nursing stage." Journal of Experimental Biology and Agricultural Sciences 10, no. 5 (2022): 1115–20. http://dx.doi.org/10.18006/2022.10(5).1115.1120.

Full text

Abstract:

This study aimed to determine the effect of a commercial diet's protein level on the fry-to-fingerling stage. Thirty days-old fries having the initial length and weight of 18.25 ± 0.15 mm fish-1 and 0.036 ± 0.50 g fish-1 respectively have been used in this study. Diet having three protein levels i.e. 30% (trial 1 as control), 35% (trial 2), 40% (trial 3), and 45% (trial 4), respectively, have been used to evaluate the effect of protein, and each trial has been repeated three times. During the study, stocking density was allocated to 1000 fish per composite tank with a volume of 1 m3. After 30

APA, Harvard, Vancouver, ISO, and other styles

26

Christ, L., A. Gloor, F. Kollert, S. Reichenbach, and P. Villiger. "POS0265 SERUM PROTEOMICS IN GIANT CELL ARTERITIS IN RESPONSE TO A THREE-DAY PULSE OF GLUCOCORTICOID FOLLOWED BY TOCILIZUMAB MONOTHERAPY (THE GUSTO TRIAL)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 374.2–375. http://dx.doi.org/10.1136/annrheumdis-2022-eular.434.

Full text

Abstract:

BackgroundMeasuring disease activity in Giant Cell Arteritis (GCA) remains a challenge, particularly, if Tocilizumab (TCZ) is prescribed which blunts the acute phase response. A proteome analysis may not only serve to identify biomarkers, but also to shed light on pathophysiology. The sequential administration of Glucocorticoids (GC) and TCZ as done in the GUSTO study (GCA treatment with ultra-short GC and TCZ) provides a unique opportunity to dissect the effects of GC and TCZ.ObjectivesTo investigate the effects of pulse GC-treatment and of ensuing long-term TCZ monotherapy on serum proteins

APA, Harvard, Vancouver, ISO, and other styles

27

Ferreira, Antonio, Ahmed Fahiem Abdelsalam Emara, David Herzig, et al. "Study protocol for a randomised, double-blind, placebo-controlled crossover trial assessing the impact of the SGLT2 inhibitor empagliflozin on postprandial hypoglycaemia after gastric bypass." BMJ Open 12, no. 9 (2022): e060668. http://dx.doi.org/10.1136/bmjopen-2021-060668.

Full text

Abstract:

IntroductionPostprandial hypoglycaemia after gastric bypass surgery (also known as postbariatric hypoglycaemia or PBH) is an increasingly encountered clinical problem. PBH is characterised by meal-induced rapid spikes and consequent falls in glycaemia, resulting in both hypoglycaemia burden and high glycaemic variability. Despite its frequency, there is currently no approved pharmacotherapy. The purpose of this investigation is to evaluate efficacy and safety of empagliflozin 25 mg, a sodium-glucose cotransporter 2-inhibitor, to reduce glucose excursions and hypoglycaemia burden in patients wi

APA, Harvard, Vancouver, ISO, and other styles

28

Gutersohn, Caterina, Sandra Schweingruber, Maximilian Haudenschild, Markus Huber, Robert Greif, and Alexander Fuchs. "Medical device education: study protocol for a randomised controlled trial comparing self-directed learning with traditional instructor-led learning on an anaesthesia workstation." BMJ Open 13, no. 9 (2023): e070261. http://dx.doi.org/10.1136/bmjopen-2022-070261.

Full text

Abstract:

IntroductionContinuous professional development is essential for maintaining competencies in healthcare. This applies to medical device knowledge and safe handling, which are fundamental for patient safety. Little is known about the efficiency of self-directed learning with an integrated video in medical device education. This study investigates whether anaesthesia providers acquire their medical device competencies on an anaesthesia workstation differently via self-directed learning than traditional teacher-led workshops.Methods and analysisThis single-centre, non-inferiority, randomised, con

APA, Harvard, Vancouver, ISO, and other styles

29

Senn, H. J., R. Maibach, M. Castiglione, et al. "Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82." Journal of Clinical Oncology 15, no. 7 (1997): 2502–9. http://dx.doi.org/10.1200/jco.1997.15.7.2502.

Full text

Abstract:

PURPOSE To compare two adjuvant combination chemotherapies, cyclophosphamide, methotrexate, and fluorouracil (CMF) and chlorambucil, methotrexate, and fluorouracil (LMF), for patients who had undergone potentially curative surgery for unilateral breast cancer, in terms of relapse, survival, and toxicity. PATIENTS AND METHODS Selection criteria was as follows: stage pT1-3a, N+ or N-, M0, less than 72 years of age. Eligible patients were randomized to receive either CMF (cyclophosphamide 100 mg/m2 orally on days 1 to 14, methotrexate 40 mg/m2 intravenously (I.V.) on days 1 and 8, fluorouracil 60

APA, Harvard, Vancouver, ISO, and other styles

30

Meier, Bernhard. "Closing the Patent Foramen Ovale with Amplatzer Devices." European Cardiology Review 5, no. 1 (2009): 71. http://dx.doi.org/10.15420/ecr.2009.5.1.71.

Full text

Abstract:

The relative risk of a thromboembolic event is four-fold higher in the 25–35% of adults with a patent foramen ovale (PFO) and 33-fold higher in patients who also have an atrial septal aneurysm. The American PICSS trial showed a yearly incidence of stroke or death after an initial event of 5% with warfarin and 9% with acetylsalicylic acid. The presence of a PFO more than doubles the mortality rate in patients with clinically relevant pulmonary embolism. The risk of a PFO increases with age. Proof of effectiveness in migraine alleviation is likely to be achievable in a couple of years – much qui

APA, Harvard, Vancouver, ISO, and other styles

31

Wittneben, J. G., J. Gavric, U. C. Belser, et al. "Esthetic and Clinical Performance of Implant-Supported All-Ceramic Crowns Made with Prefabricated or CAD/CAM Zirconia Abutments: A Randomized, Multicenter Clinical Trial." Journal of Dental Research 96, no. 2 (2016): 163–70. http://dx.doi.org/10.1177/0022034516681767.

Full text

Abstract:

Patients’ esthetic expectations are increasing, and the options of the prosthetic pathways are currently evolving. The objective of this randomized multicenter clinical trial was to assess and compare the esthetic outcome and clinical performance of anterior maxillary all-ceramic implant crowns (ICs) based either on prefabricated zirconia abutments veneered with pressed ceramics or on CAD/CAM zirconia abutments veneered with hand buildup technique. The null hypothesis was that there is no statistically significant difference between the 2 groups. Forty implants were inserted in sites 14 to 24

APA, Harvard, Vancouver, ISO, and other styles

32

Schindera, Christina, Claudia Elisabeth Kuehni, Mladen Pavlovic, et al. "Diagnosing Preclinical Cardiac Dysfunction in Swiss Childhood Cancer Survivors: Protocol for a Single-Center Cohort Study." JMIR Research Protocols 9, no. 6 (2020): e17724. http://dx.doi.org/10.2196/17724.

Full text

Abstract:

Background Cardiovascular disease is the leading nonmalignant cause of late deaths in childhood cancer survivors. Cardiovascular disease and cardiac dysfunction can remain asymptomatic for many years, but eventually lead to progressive disease with high morbidity and mortality. Early detection and intervention are therefore crucial to improve outcomes. Objective In our study, we aim to assess the prevalence of preclinical cardiac dysfunction in adult childhood cancer survivors using conventional and speckle tracking echocardiography; determine the association between cardiac dysfunction and tr

APA, Harvard, Vancouver, ISO, and other styles

33

Schmid, Julia, Bianca Schmidli, Lisa Hillebrecht, et al. "Physical activity counseling within the «KiKli Fit»-project: Development and first implementation." Current Issues in Sport Science (CISS) 9, no. 2 (2024): 018. http://dx.doi.org/10.36950/2024.2ciss018.

Full text

Abstract:

Introduction Increasing physical activity (PA) levels in children and adolescents with cancer holds promise for enhancing outcomes both during treatment and into survivorship (Stout et al., 2017). Despite this potential, the promotion of PA within Swiss pediatric oncology units remains largely overlooked. To address this gap, the “KiKli Fit” project has been initiated. This program features personalized training sessions during acute care, accompanied by PA counseling during the transition to the post-acute phase. Importantly, it engages not only the patients but also their families, since the

APA, Harvard, Vancouver, ISO, and other styles

34

Weber, Manuel, Anja Maria Raab, Kai-Uwe Schmitt, et al. "Efficacy of a digital lifestyle intervention on health-related QUAlity of life in non-small cell LUng CAncer survivors following inpatient rehabilitation: protocol of the QUALUCA Swiss multicentre randomised controlled trial." BMJ Open 14, no. 3 (2024): e081397. http://dx.doi.org/10.1136/bmjopen-2023-081397.

Full text

Abstract:

Introduction Non-small cell lung cancer (NSCLC) survivors suffer from impaired physical and psychological functioning and reduced health-related quality of life (HRQoL) that persist after active treatment ends. Sustaining rehabilitation benefits, promoting a healthy lifestyle and facilitating self-management at home require a multifaceted aftercare programme. We aim to investigate the effect of a 12-week digital lifestyle intervention on HRQoL and lifestyle-related outcomes in NSCLC survivors after completion of inpatient rehabilitation. Methods and analysis QUAlity of life in LUng CAncer Surv

APA, Harvard, Vancouver, ISO, and other styles

35

Stuby, Loric, Ludivine Currat, Birgit Gartner, et al. "Impact of Face-to-Face Teaching in Addition to Electronic Learning on Personal Protective Equipment Doffing Proficiency in Student Paramedics: Protocol for a Randomized Controlled Trial." JMIR Research Protocols 10, no. 4 (2021): e26927. http://dx.doi.org/10.2196/26927.

Full text

Abstract:

Background The COVID-19 pandemic has brought attention to the importance of correctly using personal protective equipment (PPE). Doffing is a critical phase that increases the risk of contamination of health care workers. Although a gamified electronic learning (e-learning) module has been shown to increase the adequate choice of PPE among prehospital personnel, it failed to enhance knowledge regarding donning and doffing sequences. Adding other training modalities such as face-to-face training to these e-learning tools is therefore necessary to increase prehospital staff proficiency and thus

APA, Harvard, Vancouver, ISO, and other styles

36

Noetzel, David, and Becky Sheets. "Potato Leafhopper Control in Dry (Kidney) Bean, 1992." Insecticide and Acaricide Tests 18, no. 1 (1993): 82. http://dx.doi.org/10.1093/iat/18.1.82.

Full text

Abstract:

Abstract In earlier trials on navy bean, insecticide use against foliar insects appeared to reduce yields. This trial was established at the Staples Irrigation Station using kidney bean as the plant host. The field was planted on 20 May with 4 row plots, each row 0.76 m wide and 7.6 m long, arranged in a randomized complete block design, replicated 4 times. Soil treatments were banded in a 10 cm. band over the row the day of planting. Foliars were applied on 11 and 29 Jul using 2 liter of total material on 0.0023 ha. All plots were regularly irrigated. Data on stand, moisture and yield were co

APA, Harvard, Vancouver, ISO, and other styles

37

Schoffski, Patrick, Che-Jui Lee, Tom Van Cann, et al. "Establishment of a tissue microarray (TMA) platform as an efficient tool for soft tissue sarcoma (STS) research available for collaboration." Journal of Global Oncology 5, suppl (2019): 38. http://dx.doi.org/10.1200/jgo.2019.5.suppl.38.

Full text

Abstract:

38 Background: STS is a very heterogeneous family of orphan malignancies, characterized by morphological and genetic diversity. Tissue samples from individual STS patients are commonly used for routine diagnostic and research purposes. TMAs from multiple sarcoma tissue blocks have potential advantages over conventional tissue analysis in terms of efficiency and cost-effectiveness. We have established a comprehensive sarcoma TMA research platform. Methods: TMAs were constructed using left-over tissue from STS patients diagnosed at University Hospitals Leuven (B), Leiden University Medical Cente

APA, Harvard, Vancouver, ISO, and other styles

38

Hlubocky, F. J., E. Larson, G. Sachs, and C. K. Daugherty. "A study of informed consent (IC), age, and cognitive function (CF) among advanced cancer patients (acp) in phase I trials." Journal of Clinical Oncology 25, no. 18_suppl (2007): 6548. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.6548.

Full text

Abstract:

6548 Background: Ethical concerns exist about acps’ ability to provide adequate informed consent (IC) for phase I trials. While cognitive impairment (CI) among acp is well-recognized due to multiple factors, e.g., previous effects of chemotherapy, age, psychological status, the prevalence of CI among acp in phase I trials has never been described. Methods: Acp CF was assessed using a neuropsychological battery of instruments: Hopkins Verbal Learning (HVLT); Verbal Fluency; Mini-Cognitive Assessment; Trail-making (Parts A& B); Boston Naming (short); WAIS subtests (Comprehension and Digit Sp

APA, Harvard, Vancouver, ISO, and other styles

39

Kness, Andrew A., Gordon Johnson, Kathryne L. Everts, Thomas A. Evans, Nicole M. Donofrio, and Emmalea G. Ernest. "Managing Pod Rot of Lima Bean Caused by Phytophthora capsici with Fungicides in the Mid-Atlantic Region." Plant Health Progress 17, no. 2 (2016): 130–32. http://dx.doi.org/10.1094/php-br-16-0015.

Full text

Abstract:

The baby lima bean (Phaseolus lunatus) is one of the most economically important crops for Delaware. Pod rot of lima bean caused by Phytophthora capsici is a relatively new disease that threatens production and profitability of lima beans grown in Delaware and the mid-Atlantic region. Insensitivity to the fungicide mefenoxam has made managing the disease challenging in recent years. In 2014, 12 fungicides in two trials were tested for their efficacy against P. capsici in lima bean. Results indicated that all fungicide treatments significantly reduced disease incidence compared to the control,

APA, Harvard, Vancouver, ISO, and other styles

40

Kundu, Manjari, Yoshimi Endo Greer, Jennifer L. Dine, and Stanley Lipkowitz. "Targeting TRAIL Death Receptors in Triple-Negative Breast Cancers: Challenges and Strategies for Cancer Therapy." Cells 11, no. 23 (2022): 3717. http://dx.doi.org/10.3390/cells11233717.

Full text

Abstract:

The tumor necrosis factor (TNF) superfamily member TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cells via death receptor (DR) activation with little toxicity to normal cells or tissues. The selectivity for activating apoptosis in cancer cells confers an ideal therapeutic characteristic to TRAIL, which has led to the development and clinical testing of many DR agonists. However, TRAIL/DR targeting therapies have been widely ineffective in clinical trials of various malignancies for reasons that remain poorly understood. Triple negative breast cancer (TNBC) has the w

APA, Harvard, Vancouver, ISO, and other styles

41

Rogan, Slavko, Eefje Luijckx, Jan Taeymans, Karin Haas, and Heiner Baur. "Physical Activity, Nutritional Habits, and Sleep Behavior Among Health Profession Students and Employees of a Swiss University During and After COVID-19 Confinement: Protocol for a Longitudinal Observational Study." JMIR Research Protocols 9, no. 12 (2020): e25051. http://dx.doi.org/10.2196/25051.

Full text

Abstract:

Background SARS-CoV-2, a novel coronavirus strain, has resulted in the COVID-19 pandemic since early 2020. To contain the transmission of this virus, the Swiss Federal Council ordered a nationwide lockdown of all nonessential businesses. Accordingly, students and employees of institutions for higher education were informed to continue their academic programs through home-office settings and online lectures. Objective This longitudinal survey aims to evaluate various lifestyle habits such as physical activity, nutritional habits, and sleep behavior among students and employees of a Swiss Univer

APA, Harvard, Vancouver, ISO, and other styles

42

Allan, C., A. Chapman, C. Parker, A. Boltong, and J. Millar. "Missing Evidence: Exploring Unpublished Trials in Victoria, Australia." Journal of Global Oncology 4, Supplement 2 (2018): 96s. http://dx.doi.org/10.1200/jgo.18.28700.

Full text

Abstract:

Background: Clinical trial registries were established to improve the transparency and completeness of clinical trial reporting and a number of policies have been introduced to encourage or mandate their use. While prospective trial registration has been endorsed in Australia, there is currently no legal requirement for researchers to register or communicate findings from clinical trials. There has also been, to the best of our knowledge, no analysis previously undertaken on publication rates for clinical trials performed in Australia. Aim: We aimed to determine the proportion of clinical tria

APA, Harvard, Vancouver, ISO, and other styles

43

Ellaway-Barnard, Christopher, Hannah Killick, Guy Peryer, Jane L. Cross, and Toby O. Smith. "The association between registration status and reported outcomes in physiotherapy randomised controlled trials." International Journal of Therapy and Rehabilitation 27, no. 3 (2020): 1–15. http://dx.doi.org/10.12968/ijtr.2019.0023.

Full text

Abstract:

Background/Aims Clinical trial registration has been proposed as a method of mitigating selective reporting in scientific research. It remains unknown whether trial registration is associated with reported outcomes in physiotherapy trials. This study aimed to analyse the association between registration status and outcome (the rejection or acceptance of a primary null hypothesis) for physiotherapy randomised controlled trials. Methods All randomised controlled trials reporting a physiotherapy intervention in publications listed in PubMed between 1 January 2017 and 30 June 2017 were included. T

APA, Harvard, Vancouver, ISO, and other styles

44

Park, Hyungkwan. "The Principle of the Judge immobility and Public Trial Base Principle." Korean Association of Criminal Procedure Law 15, no. 4 (2023): 97–129. http://dx.doi.org/10.34222/kdps.2023.15.4.97.

Full text

Abstract:

Under the Korean Supreme Court Personnel Order, a regular transfer of judges to different jurisdictions is effected at preset terms. This practice is highly unusual and although the practice was undoubtedly a measure in securing a more sound legal system, troubling side effects have occurred. Two prominent examples include the undermining of the right of a citizen's right to a speedy trial and a weakening of the public trial principle. Changing judges during a trial is akin to changing an umpire during a sporting event. The practice is not only inefficient but places an unfair burden on

APA, Harvard, Vancouver, ISO, and other styles

45

Cullen, Stephen M., Mairi-Ann Cullen, and Geoff Lindsay. "The CANparent trial-the delivery of universal parenting education in England." British Educational Research Journal 43, no. 4 (2017): 759–80. http://dx.doi.org/10.1002/berj.3282.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Nwadike, Christopher, Terkimbi Vange, and A.E. Ochigbo. "Genotype - Environment Interaction for Plant Development and Some Yield Components in Common Bean (Phaseolus vulgaris L.) during the 2012 Wet Season." Greener Journal of Plant Breeding and Crop Science 2, no. 1 (2014): 1–8. https://doi.org/10.15580/gjpbcs.2014.1.102913936.

Full text

Abstract:

A multi- location field trial was conducted at two location to estimate genotype by environment interaction for growth, yield and yield characters in nine accession lines of common bean <em>Phaseolus vulgaris</em> L. A randomised complete block design with three replication was use for the field trials. A highly significant differences among the tested genotypes in the two environments were detected for Leaf count, Days after Sowing to first flowering, Days after Sowing to 50% flowering, Plant height at 50% flowering, Pod count per plant, Pod length per plant, Seed diameter per pod,

APA, Harvard, Vancouver, ISO, and other styles

47

Tion, M. A., and P. C. Njoku. "Assessing calcium availability from limestone sources through bone and blood status of chickens." Nigerian Journal of Animal Production 36, no. 1 (2021): 85–95. http://dx.doi.org/10.51791/njap.v36i1.1396.

Full text

Abstract:

Calcium (Cu) availability from limestone (procured from different cement factories) was assessed through bone and blood status of chickens using the completely randomized design. Five hundred and twenty five (525) straight run broiler chicks that were 28 days Of age (trial l), four hundred and twenty (420) broiler finishers that were 56 days of age (trial 2), and 210 layers that had been laying for six months (trial 3) were used in the study. Six limestone dietary treatments and a control accounted for the seven diets that were assessed Twelve birds per treatment and 4 per replicate that had t

APA, Harvard, Vancouver, ISO, and other styles

48

Bruckner, Till, Daniel Sanchez, Tarik Suljic, et al. "Regulatory gaps and research waste in clinical trials involving women with metastatic breast cancer in Germany." F1000Research 13 (May 1, 2024): 431. http://dx.doi.org/10.12688/f1000research.148958.1.

Full text

Abstract:

Background Non-publication, incomplete publication and excessively slow publication of clinical trial outcomes contribute to research waste and can harm patients. While research waste in German academic trials is well documented, research waste in Germany related to a specific disease area across non-commercial and commercial sponsors has not previously been assessed. Methods In this cohort study, we used public records from three clinical trial registries to identify 70 completed or terminated clinical trials involving women with metastatic breast cancer with trial sites in Germany. We then s

APA, Harvard, Vancouver, ISO, and other styles

49

Tornhammar, Per, Alexander Julner, Nader Al Moosawi, et al. "Completion and reporting of COVID-19 clinical trials registered on ClinicalTrials.gov during the first 6 months of the pandemic: cohort study." BMJ Open 14, no. 11 (2024): e085906. http://dx.doi.org/10.1136/bmjopen-2024-085906.

Full text

Abstract:

BackgroundEarly in the COVID-19 pandemic, numerous clinical trials were initiated. Although concerns were raised regarding the quality of the trials, the eventual research output yielded from the trials remains unknown. The objective of this study was to include all clinical trials registered on ClinicalTrials.gov during the first 6 months of the pandemic and assess if and where their results had been reported, their completion and discontinuation rates, achieved enrolment and changes made to the primary outcome after trial registration.MethodsWe included all interventional studies related to

APA, Harvard, Vancouver, ISO, and other styles

50

Pokhrel, Anil, and Padam Prasad Poudel. "Yield and Yield Attributing Characters of Different Varieties of Kidney Bean (Phaseolus vulgaris L.) in Western Nepal." Asian Plant Research Journal 13, no. 4 (2025): 24–30. https://doi.org/10.9734/aprj/2025/v13i4314.

Full text

Abstract:

Kidney bean (Phaseolus vulgaris L.), locally known as Rajma, is popular from the Terai to the Hills of Nepal. Its current national productivity is low at 1.2 t/ha, and stagnant due to the limited availability of high-yielding varieties, inappropriate sowing times, and suboptimal agronomic practices. To address this gap and identify promising genotypes for varietal release, a series of multi-year trials were conducted during the winters of 2022/23 and 2023/24 in the Grain Legumes Research Program (GLRP), Khajura, Banke, Nepal. These trials included an Observation Nursery (OBN) with 24 genotypes

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!