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Journal articles on the topic 'Berry development transcriptomic route'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Fasoli, Marianna, Chandra L. Richter, Sara Zenoni, et al. "Towards the definition of a detailed transcriptomic map of berry development." BIO Web of Conferences 13 (2019): 01001. http://dx.doi.org/10.1051/bioconf/20191301001.

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The progress of the grapevine genomics and the development of high-throughput technologies for gene expression analysis stimulated the investigation of the physical, biochemical and physiological changes of grape berry growth and maturation at transcriptomic level. The molecular information generated in the last decade is however still fragmented since it relies upon detailed analysis of few stages and thus lacks continuity over grape development. To identify the molecular events associated with berry development at a higher temporal resolution and define a transcriptomic map, we performed RNA

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2

Glissant, David, Fabienne Dédaldéchamp, and Serge Delrot. "Transcriptomic analysis of grape berry softening during ripening." OENO One 42, no. 1 (2008): 1. http://dx.doi.org/10.20870/oeno-one.2008.42.1.830.

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<p style="text-align: justify;"><strong>Aims</strong>: The aim of this paper was to use recent transcriptomic tools available for grape in order to understand berry softening.</p><p style="text-align: justify;"><strong>Methods and results</strong>: A microarray bearing specific 50 mer oligonucleotide for 3,200 genes was used to study gene expression along 8 stages of berry development in Chardonnay and Shiraz berries. Transcripts corresponding to aquaporin genes and to genes involved in cell wall metabolism were studied in detail and ranked according t

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Deluc, Laurent G., Jérôme Grimplet, Matthew D. Wheatley, et al. "Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development." BMC Genomics 8, no. 1 (2007): 429. http://dx.doi.org/10.1186/1471-2164-8-429.

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4

Leng, Feng, Yue Wang, Jinping Cao, et al. "Transcriptomic Analysis of Root Restriction Effects on the Primary Metabolites during Grape Berry Development and Ripening." Genes 13, no. 2 (2022): 281. http://dx.doi.org/10.3390/genes13020281.

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Root restriction (RR) has been reported to enhance grape berry quality in diverse aspects of grape life. In this study, RR-induced increases in the main primary metabolites in the grape berry and the expression of their related genes were studied at different developmental stages. Mainly the transcriptomic and metabolomic level were analyzed using ‘Summer Black’ grape berry as a material. The main results were as follows: A total of 11 transcripts involved in the primary metabolic pathways were significantly changed by the RR treatment. Metabolites such as sugars, organic acids, amino acids, s

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Yang, Qiaofeng, Changlin Li, Yan Wang, et al. "Transcriptome and Metabolome Analyses of Flavonoid Biosynthesis During Berry Development of Muscadine Grape (Vitis rotundifolia Michx)." Plants 14, no. 13 (2025): 2025. https://doi.org/10.3390/plants14132025.

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Flavonoids play a crucial role in plant development, resistance, and the pigmentation of fruits and flowers. This study aimed to uncover the mechanism of flavonoid biosynthesis and fruit coloring in muscadine grapes. Two muscadine genotypes (Paulk and Supreme) were investigated via metabolomic and transcriptomic analysis during three developmental stages (bunch closure, veraison stage, and ripening stage). A total of 314 flavonoids were identified, with flavones and flavonols being the primary constituents. The contents of many differentially accumulated metabolites (DAMs) were higher at the v

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Dimopoulos, Nicolas, Ricco Tindjau, Darren C. J. Wong, et al. "Drought stress modulates cuticular wax composition of the grape berry." Journal of Experimental Botany 71, no. 10 (2020): 3126–41. http://dx.doi.org/10.1093/jxb/eraa046.

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Abstract Drought events are a major challenge for many horticultural crops, including grapes, which are often cultivated in dry and warm climates. It is not understood how the cuticle contributes to the grape berry response to water deficit (WD); furthermore, the cuticular waxes and the related biosynthetic pathways are poorly characterized in this fruit. In this study, we identified candidate wax-related genes from the grapevine genome by phylogenetic and transcriptomic analyses. Developmental and stress response expression patterns of these candidates were characterized across pre-existing R

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Botton, Alessandro, Francesco Girardi, Benedetto Ruperti, et al. "Grape Berry Responses to Sequential Flooding and Heatwave Events: A Physiological, Transcriptional, and Metabolic Overview." Plants 11, no. 24 (2022): 3574. http://dx.doi.org/10.3390/plants11243574.

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Grapevine cultivation, such as the whole horticulture, is currently challenged by several factors, among which the extreme weather events occurring under the climate change scenario are the most relevant. Within this context, the present study aims at characterizing at the berry level the physiological response of Vitis vinifera cv. Sauvignon Blanc to sequential stresses simulated under a semi-controlled environment: flooding at bud-break followed by multiple summer stress (drought plus heatwave) occurring at pre-vèraison. Transcriptomic and metabolomic assessments were performed through RNASe

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Qin, Xiaoya, Beibei Qin, Wei He, et al. "Metabolomic and Transcriptomic Analyses of Lycium barbarum L. under Heat Stress." Sustainability 14, no. 19 (2022): 12617. http://dx.doi.org/10.3390/su141912617.

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Heat stress has a strong and detrimental effect on plant growth and yield. Goji berry or wolfberry (Lycium barbarum L.) is a dual-purpose medicinal and food plant but an increase in high temperatures has caused a serious decline in wolfberry yield and quality. In this study, we first explored the heat stress responses of Goji berry, and found that heat stress adaptation mechanisms fluctuated over 48 h. Moreover, L.barbarum 1402 was more heat resistant while L.barbarum Ningqi No. 7 (N7) was sensitive to high temperatures, in which amino acids and alkaloids played key roles; expression and accum

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Torregrosa, Laurent, Antoine Bigard, Agnes Doligez, et al. "Developmental, molecular and genetic studies on grapevine response to temperature open breeding strategies for adaptation to warming." OENO One 51, no. 2 (2017): 155–65. http://dx.doi.org/10.20870/oeno-one.2017.51.2.1587.

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Aim: In the long term, genetic improvement is one of the major strategies to support sustainable wine production in a changing climate. Over the past 5 years, we have developed an interdisciplinary research program that aimed to: i) characterize the impact of temperature increase sensed by the entire plant or individual bunches on the development and functioning of the plant, ii) identify the physiological and molecular mechanisms regulating the response of vegetative and reproductive development to heat stress and iii) develop tools to map quantitative trait loci (QTLs) of plant and berry dev

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Rienth, Markus, Laurent Torregrosa, Mary T. Kelly, et al. "Is Transcriptomic Regulation of Berry Development More Important at Night than During the Day?" PLoS ONE 9, no. 2 (2014): e88844. http://dx.doi.org/10.1371/journal.pone.0088844.

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11

Wang, Qianlan, Huan Zheng, Shimin Gao, Hui Li, and Jianmin Tao. "Transcriptomic analysis of berry development and a corresponding analysis of anthocyanin biosynthesis in teinturier grape." Journal of Plant Interactions 14, no. 1 (2019): 617–29. http://dx.doi.org/10.1080/17429145.2019.1680754.

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12

Leng, Feng, Jinping Cao, Zhiwei Ge, et al. "Transcriptomic Analysis of Root Restriction Effects on Phenolic Metabolites during Grape Berry Development and Ripening." Journal of Agricultural and Food Chemistry 68, no. 34 (2020): 9090–99. http://dx.doi.org/10.1021/acs.jafc.0c02488.

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13

Huang, Jianquan, Guan Zhang, Yanhao Li, et al. "Integrative genomic and transcriptomic analyses of a bud sport mutant ‘Jinzao Wuhe’ with the phenotype of large berries in grapevines." PeerJ 11 (January 3, 2023): e14617. http://dx.doi.org/10.7717/peerj.14617.

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Background Bud sport mutation occurs frequently in fruit plants and acts as an important approach for grapevine improvement and breeding. ‘Jinzao Wuhe’ is a bud sport of the elite cultivar ‘Himord Seedless’ with obviously enlarged organs and berries. To date, the molecular mechanisms underlying berry enlargement caused by bud sport in grapevines remain unclear. Methods Whole genome resequencing (WGRS) was performed for two pairs of bud sports and their maternal plants with similar phenotype to identify SNPs, InDels and structural variations (SVs) as well as related genes. Furthermore, transcri

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Torregrosa, Laurent, Antoine Bigard, Agnes Doligez, et al. "Developmental, molecular and genetic studies on grapevine response to temperature open breeding strategies for adaptation to warming." OENO One 51, no. 2 (2017): 155. http://dx.doi.org/10.20870/oeno-one.2016.0.0.1587.

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<p class="Abstract" style="text-align: justify;"><strong>Aim:</strong> In the long term, genetic improvement is one of the major strategies to support sustainable wine production in a changing climate. Over the past 5 years, we have developed an interdisciplinary research program that aimed to: i) characterize the impact of temperature increase sensed by the entire plant or individual bunches on the development and functioning of the plant, ii) identify the physiological and molecular mechanisms regulating the response of vegetative and reproductive development to heat stress

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15

Zhang, Kekun, Wanping Li, Yanlun Ju, et al. "Transcriptomic and Metabolomic Basis of Short- and Long-Term Post-Harvest UV-C Application in Regulating Grape Berry Quality Development." Foods 10, no. 3 (2021): 625. http://dx.doi.org/10.3390/foods10030625.

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In this study, ultraviolet-C (UV-C) was utilized to improve the quality of post-harvest grape berries, and the transcriptomic and metabolomic basis of this improvement was elucidated. Berries of the red grape variety ‘Zicui’ and the white variety ‘Xiangfei’ were chosen to evaluate the effect of short- and long-term UV-C irradiation. Post-harvest UV-C application promoted malondialdehyde (MDA) and proline accumulation, and reduced the soluble solid content in berries. Both the variety and duration of irradiation could modulate the transcriptomic and metabolomic responses of berries to UV-C. Com

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Song, Yashu, Robert H. Hanner, and Baozhong Meng. "Transcriptomic Analyses of Grapevine Leafroll-Associated Virus 3 Infection in Leaves and Berries of ‘Cabernet Franc’." Viruses 14, no. 8 (2022): 1831. http://dx.doi.org/10.3390/v14081831.

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Grapevine leafroll-associated virus 3 (GLRaV-3) is one of the most important viruses affecting global grape and wine production. GLRaV-3 is the chief agent associated with grapevine leafroll disease (GLRD), the most prevalent and economically destructive grapevine viral disease complex. Response of grapevine to GLRaV-3 infection at the gene expression level is poorly characterized, limiting the understanding of GLRaV-3 pathogenesis and viral-associated symptom development. In this research, we used RNA-Seq to profile the changes in global gene expression of Cabernet franc, a premium red wine g

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17

Leng, Feng, Jinping Cao, Shiping Wang, Ling Jiang, Xian Li, and Chongde Sun. "Transcriptomic Analyses of Root Restriction Effects on Phytohormone Content and Signal Transduction during Grape Berry Development and Ripening." International Journal of Molecular Sciences 19, no. 8 (2018): 2300. http://dx.doi.org/10.3390/ijms19082300.

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Phytohormones strongly influence growth, development and nutritional quality of agricultural products by modulating molecular and biochemical changes. The purpose of the present study was to investigate the influence of root restriction (RR) treatment on the dynamic changes of main phytohormones during the berry development and ripening of “Summer Black” early ripening seedless grape (Vitis vinifera × V. labrusca), and to analyze the changes in the biosynthesis and signal transduction pathways of phytohormones by transcriptomics. Enzyme-linked immunosorbent assay (ELISA) and Ultra Performance

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Leng, Feng, Dandan Tang, Qiong Lin, et al. "Transcriptomic Analyses of Ascorbic Acid and Carotenoid Metabolites Influenced by Root Restriction during Grape Berry Development and Ripening." Journal of Agricultural and Food Chemistry 65, no. 9 (2017): 2008–16. http://dx.doi.org/10.1021/acs.jafc.6b05322.

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19

Li, Xiangyi, Yixuan Yan, Lei Wang, et al. "Integrated Transcriptomic and Metabolomic Analysis Revealed Abscisic Acid-Induced Regulation of Monoterpene Biosynthesis in Grape Berries." Plants 13, no. 13 (2024): 1862. http://dx.doi.org/10.3390/plants13131862.

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Monoterpenes are a class of volatile organic compounds that play crucial roles in imparting floral and fruity aromas to Muscat-type grapes. However, our understanding of the regulatory mechanisms underpinning monoterpene biosynthesis in grapes, particularly following abscisic acid (ABA) treatment, remains elusive. This study aimed to explore the impact of exogenous ABA on monoterpene biosynthesis in Ruiduhongyu grape berries by employing Headspace Solid-Phase Micro-Extraction Gas Chromatography–Mass Spectrometry (HS-SPME/GC–MS) analysis and transcriptome sequencing. The results suggested signi

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20

Wang, Tengfei, Huixiang Peng, Yingying Cao, et al. "Dynamic Network Biomarker Analysis Reveals the Critical Phase Transition of Fruit Ripening in Grapevine." Genes 13, no. 10 (2022): 1851. http://dx.doi.org/10.3390/genes13101851.

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Grapevine (Vitis vinifera L.) fruit ripening is a complex biological process involving a phase transition from immature to mature. Understanding the molecular mechanism of fruit ripening is critical for grapevine fruit storage and quality improvement. However, the regulatory mechanism for the critical phase transition of fruit ripening from immature to mature in grapevine remains poorly understood. In this work, to identify the key molecular events controlling the critical phase transition of grapevine fruit ripening, we performed an integrated dynamic network analysis on time-series transcrip

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21

Shi, Mengyao, Stefania Savoi, Gautier Sarah, et al. "Vitis rotundifolia Genes Introgressed with RUN1 and RPV1: Poor Recombination and Impact on V. vinifera Berry Transcriptome." Plants 13, no. 15 (2024): 2095. http://dx.doi.org/10.3390/plants13152095.

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Thanks to several Vitis vinifera backcrosses with an initial V. vinifera L. × V. rotundifolia (previously Muscadinia rotundifolia) interspecific cross, the MrRUN1/MrRPV1 locus (resistance to downy and powdery mildews) was introgressed in genotypes phenotypically close to V. vinifera varieties. To check the consequences of introgressing parts of the V. rotundifolia genome on gene expression during fruit development, we conducted a comparative RNA-seq study on single berries from different V. vinifera cultivars and V. vinifera × V. rotundifolia hybrids, including ‘G5’ and two derivative microvin

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22

Li, Yuan, Caiming Xu, and Ajay Goel. "Abstract 523: Aronia berry and oligomeric proanthocyanidins synergistically exhibit anticancer effects in colorectal cancer by inhibiting LMNB1." Cancer Research 84, no. 6_Supplement (2024): 523. http://dx.doi.org/10.1158/1538-7445.am2024-523.

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Abstract Background: Colorectal cancer (CRC) is one of the most common and recurrent diseases globally, ranking as the second leading cause of mortality. The high mortality rates associated with this disease are largely due to the ineffectiveness of current treatments and the development of chemotherapeutic resistance to conventional therapies. In recent years, several natural agents, such as Aronia berry extract (ABE) and oligomeric proanthocyanidins (OPCs), have shown promise in providing a safe, cost-effective, and synergistically multi-targeted treatment approach across various cancers. He

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Li, Yuan, Caiming Xu, Haiyong Han, and Ajay Goel. "Abstract 4748: Aronia berry overcomes gemcitabine resistance by regulating the MYD88/NF-kB/P-glycoprotein pathway in pancreatic ductal adenocarcinoma." Cancer Research 84, no. 6_Supplement (2024): 4748. http://dx.doi.org/10.1158/1538-7445.am2024-4748.

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Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is lethal, which is partly due to the limited efficacy of Gemcitabine (Gem)-based chemotherapy, resulting from the development of acquired resistance to this regimen. Aronia berry extract (ABE) is a natural source of phenolic compounds known for its anti-cancer properties. Previous research has highlighted the ability of ABE to help overcome chemoresistance to conventional chemotherapies in various cancers. In this study, we interrogated the ability of ABE to overcome Gem-resistance (Gem-R) in PDAC and identify specific pathway(s) re

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Havrylova, Olena. "Gastronomic Tourism: European Experience аnd Ukrainian Practice". Modern Economics 31, № 1 (2022): 27–31. http://dx.doi.org/10.31521/modecon.v31(2022)-04.

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Abstract. The article considers gastronomic tourism and provides its definition. The peculiarities of gastrotourism in Europe are clarified, the experience of creating gastrotourism routes is analyzed, in particular the experience of Greece, Italy, Spain and Croatia in the creation of Olive Oil Roads is determined. Popular routes to Croatian and wine festivals in Slovenia are also explored. The experience of creating a gastronomic route "The Way of Wine and Taste of Ukrainian Bessarabia" is analyzed. Its prospects through the involvement of the Mykolaiv and Kherson regions are determined. Purp

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Zhou, Jing, Bingshuai Du, Yuqing Chen, Yibo Cao, Mingxin Yu, and Lingyun Zhang. "Integrative Physiological and Transcriptomic Analysis Reveals the Transition Mechanism of Sugar Phloem Unloading Route in Camellia oleifera Fruit." International Journal of Molecular Sciences 23, no. 9 (2022): 4590. http://dx.doi.org/10.3390/ijms23094590.

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Sucrose phloem unloading plays a vital role in photoassimilate distribution and storage in sink organs such as fruits and seeds. In most plants, the phloem unloading route was reported to shift between an apoplasmic and a symplasmic pattern with fruit development. However, the molecular transition mechanisms of the phloem unloading pathway still remain largely unknown. In this study, we applied RNA sequencing to profile the specific gene expression patterns for sucrose unloading in C. oleifera fruits in the apo- and symplasmic pathways that were discerned by CF fluoresce labelling. Several key

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Tenci, Rossi, Giannino, et al. "An In Situ Gelling System for the Local Treatment of Inflammatory Bowel Disease (IBD). The Loading of Maqui (Aristotelia Chilensis) Berry Extract as an Antioxidant and Anti-Inflammatory Agent." Pharmaceutics 11, no. 11 (2019): 611. http://dx.doi.org/10.3390/pharmaceutics11110611.

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The aim of the present work was the development of an innovative in situ gelling system, to be applied on the mucosa of the distal colon via rectal route. The system consisted of three polymers having different functions: gellan (GG), able to jellify in presence of ions; methylcellulose (MC), a thermosensitive polymer with a gelation temperature close to 50 °C; and hydroxypropylcellulose (HPC), a mucoadhesive polymer. The three polymers were able to act synergistically, increasing the permanence of the vehicle on the mucosa and forming a protective gel layer. A DoE approach, “simplex centroid

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Thiriot, Joseph, Yuejin Liang, James Fisher, David H. Walker, and Lynn Soong. "Host transcriptomic profiling of CD-1 outbred mice with severe clinical outcomes following infection with Orientia tsutsugamushi." PLOS Neglected Tropical Diseases 16, no. 11 (2022): e0010459. http://dx.doi.org/10.1371/journal.pntd.0010459.

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Orientia tsutsugamushi is an obligately intracellular bacterium with endothelial tropism and can cause mild to lethal scrub typhus in humans. No vaccine is available for this reemerging and severely neglected infection. Previous scrub typhus studies have utilized inbred mice, yet such models have intrinsic limitations. Thus, the development of suitable mouse models that better mimic human diseases is in great need for immunologic investigation and future vaccine studies. This study is aimed at establishing scrub typhus in outbred CD-1 mice and defining immune biomarkers related to disease seve

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Kocemba-Pilarczyk, Kinga A., Paulina Dudzik, and Katarzyna Leśkiewicz. "The relationship between expression of VIMENTIN and CD146 genes in breast cancer." Bio-Algorithms and Med-Systems 17, no. 1 (2021): 1–7. http://dx.doi.org/10.1515/bams-2020-0058.

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Abstract Objectives CD146 is an adhesive molecule that was originally reported on malignant melanoma cells as a protein crucial for cell adhesion. It is now known that high expression of the CD146 protein is not only characteristic of melanoma, but it occurs on a number of cancers, contributing to worse prognosis and increased aggressiveness. Independent in vitro studies in breast cancer have shown that CD146 protein alone can induce a change in epithelial to mesenchymal transcriptional profile, which is the basis of the tumor aggressiveness and metastasis. Methods In the following work, the c

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Song, M.-K., H.-S. Lee, H.-S. Choi, et al. "Octanal-induced inflammatory responses in cells relevant for lung toxicity." Human & Experimental Toxicology 33, no. 7 (2013): 710–21. http://dx.doi.org/10.1177/0960327113506722.

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Inhalation is an important route of aldehyde exposure, and lung is one of the main targets of aldehyde toxicity. Octanal is distributed ubiquitously in the environment and is a component of indoor air pollutants. We investigated whether octanal exposure enhances the inflammatory response in the human respiratory system by increasing the expression and release of cytokines and chemokines. The effect of octanal in transcriptomic modulation was assessed in the human alveolar epithelial cell line A549 using oligonucleotide arrays. We identified a set of genes differentially expressed upon octanal

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Кожевников, А. П., А. И. Чермных та И. С. Дегтярев. "Экологические ниши и плотность ценопопуляций рябины обыкновенной (Sorbus aucuparia L.) в лесопарках Екатеринбурга". Vestnik of Volga State University of Technology Series Forest. Ecology. Nature Management, № 1(53) (29 червня 2022): 60–68. https://doi.org/10.25686/2306-2827.2022.1.60.

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Введение. В лесопарковой зоне современных урбоэкосистем происходит антропогенная трансформация лесных насаждений, выполняющих средообразующие и средостабилизирующие функции. Нарушенность в них естественных процессов приводит к изменению состава подлесочных видов и вытеснению аборигенных. Цель: мониторинг антропогенной трансформации старовозрастных сосновых насаждений лесопарковой зоны. Задачи: выявление ценотической роли Sorbus aucuparia L., определение её экологических ниш и плотности ценопопуляций. Объекты исследований: ценопопуляции Sorbus aucuparia L. пяти лесопарков Екатеринбурга: им. Лес

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Picozzi, Vincent J., Anne-Marie Duliege, Eric Andrew Collisson, et al. "Precision Promise (PrP): An adaptive, multi-arm registration trial in metastatic pancreatic ductal adenocarcinoma (PDAC)." Journal of Clinical Oncology 40, no. 16_suppl (2022): TPS4188. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.tps4188.

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TPS4188 Background: The success rate of drug development in PDAC is disappointingly low.PrP is a transformative, adaptive platform clinical trial designed to continuously evaluate many novel therapeutic options while increasing the probability that patients (pts) are randomized to effective experimental therapies. It cultivates enhanced cooperation among groups representing pts advocacy, pharmaceutical companies, academia, and the FDA. This patient-centric study aims to become the largest Phase 3 registrational study in PDAC and represents a fundamental shift in drug development for PDAC in th

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Asahi, Yoh, Keisuke Okuno, Caiming Xu, Aknobu Taketomi, and Ajay Goel. "Abstract 3822: Novel evidence for the role of the p53 signaling pathway in mediating the anticancer effects of aronia berry extract in colorectal cancer cells." Cancer Research 83, no. 7_Supplement (2023): 3822. http://dx.doi.org/10.1158/1538-7445.am2023-3822.

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Abstract Background: The development of safe and effective novel agents remains a critical challenge for improving the prognosis of patients with unresectable colorectal cancer (CRC). Natural products containing polyphenols can be a good source of anti-cancer agents for their potential effect on multiple signaling pathways with anti-cancer effect. Due to its rich polyphenols content, Aronia berry extract (ABE) is gaining increased attention as an anti-cancer agent with its protective effect against cancer cells, including CRC, exerting potent antioxidant and antiproliferative effects. Thus, we

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Atallah, Aline, Arielle Grossman, Jean-Francois Pare, Robert Siemens, Tiziana Cotechini, and Charles H. Graham. "Abstract 3540: Effect of route of Bacillus Calmette Guerin administration on the immune microenvironment and growth of bladder tumors." Cancer Research 82, no. 12_Supplement (2022): 3540. http://dx.doi.org/10.1158/1538-7445.am2022-3540.

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Abstract Background: Bladder cancer is the fifth most common cancer in North America. The standard of care for high-risk non-muscle invasive bladder cancer (NMIBC) involves intravesical immunotherapy with Bacillus Calmette Guérin (BCG). However, it is possible that the efficacy of this modality of BCG administration is suboptimal, as most patients do not respond fully to this immunotherapy. Furthermore, our current understanding of the immunotherapeutic effect of BCG is incomplete. Using a mouse model of NMIBC, we compared the tumor immune microenvironment (TiME) following intravesical versus

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Montalban-Bravo, Guillermo, Feiyang Ma, Irene Ganan-Gomez, et al. "Single-Cell RNA Sequencing Analysis Reveals Mechanisms of Initiation and Progression in Chronic Myelomonocytic Leukemia." Blood 138, Supplement 1 (2021): 2588. http://dx.doi.org/10.1182/blood-2021-151340.

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Abstract Despite advances in the genetic characterization of chronic myelomonocytic leukemia (CMML), the molecular mechanisms that drive the disease during its distinct phases remain unclear. To uncover vulnerabilities in CMML that could be therapeutically targeted to halt its evolution, we sought to dissect at the single-cell level the cellular and transcriptomic changes that occur in the hematopoietic system at the time of CMML's initiation and its progression after hypomethylating agent (HMA) therapy. To evaluate the molecular mechanisms underlying CMML maintenance, we performed single-cell

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Duguid, Alasdair, Camille Malouf, Christina Halsey, and Katrin Ottersbach. "The Impact of Lineage on CNS Infiltration Dynamics in Infant Leukaemia." Blood 144, Supplement 1 (2024): 200. https://doi.org/10.1182/blood-2024-200258.

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Infant leukaemia is a rare, aggressive form of paediatric acute leukaemia commonly associated with KMT2A gene rearrangements. There are several notable features of KMT2A-rearranged infant leukaemia, including lineage plasticity and high rates of central nervous system (CNS) involvement. In a previous study, we identified two microRNAs, miR-128a and miR-130b, upregulated in KMT2A-AFF1+ infant leukaemia patient samples. From this, we developed two immunocompetent mouse models of infant leukaemia by overexpressing these miRs individually in KMT2A-AFF1+ mouse fetal liver haematopoietic stem and pr

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Picozzi, Vincent J., Anne-Marie Duliege, Anirban Maitra, et al. "Abstract PO-050: Precision Promise (PrP): An adaptive, multi-arm registration trial in metastatic pancreatic ductal adenocarcinoma (PDAC)." Cancer Research 81, no. 22_Supplement (2021): PO—050—PO—050. http://dx.doi.org/10.1158/1538-7445.panca21-po-050.

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Abstract Background: Drug development in PDAC has been disappointing with an extremely low trial success rate despite considerable effort. PrP is a transformative, adaptive clinical trial platform that attempts to correct this by continuously and rapidly evaluating novel therapeutic options while maximizing the probability of patient (pt) randomization to an experimental treatment and nurturing enhanced cooperation among groups representing pt advocacy, pharmaceuticals, translational/clinical academia, and the FDA. This patient-centric study represents a fundamental shift in drug development f

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Zhang, Zijian, Yiyang Wang, Xinlong Luo, Xiaomei Zhan, Jun Ding, and Tao P. Wu. "Abstract 5862: Retrotransposable elements mediate the drug-tolerant persistence in claudin-low breast cancer chemo-treatment." Cancer Research 84, no. 6_Supplement (2024): 5862. http://dx.doi.org/10.1158/1538-7445.am2024-5862.

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Abstract The emergence of acquired drug resistance through treatment remains a critical threat to efficient cancer therapies, which most often lead to relapse and metastasis. The development of resistance is an evolutionary adaptation process that heavily depends on tumor heterogeneity (underpinned by cellular plasticity). Therefore, a longitudinal deconvolution of treatment adaptation is critical to uncover the driving-force mechanisms underpinning resistance adaptation. In the clinic, chemotherapy remains the mainstream treatment for TNBC, and one of the primary chemo-agents is doxorubicin.

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Faletti, Stefania, Cristina Richichi, Daniela Osti, et al. "Abstract B007: Establishment of patient-derived brain metastasis initiating cells as a novel preclinical model of breast cancer metastatization." Cancer Research 84, no. 5_Supplement_1 (2024): B007. http://dx.doi.org/10.1158/1538-7445.brain23-b007.

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Abstract Brain metastasis from breast cancer (BCBM) are lethal tumors occurring in 10-15% of IV stage breast cancers against which only limited therapeutic options are available. A critical hindrance to the design of novel therapeutic approaches is the narrow set of preclinical models to study BCBM pathophysiology, chiefly those resembling the stem-like population which is thought be the main source of BCBM dissemination and progression. We aimed to isolate patient-derived metastasis-initiating cells (MICs) to furnish novel preclinical models of metastatization. MICs were cultured as stem-enri

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Семенютина, А. В., М. В. Цой, and Н. А. Бугреев. "Evaluation of woody plants of Juniperus L. for urban greening in sparsely wooded regions." World Ecology Journal, no. 1() (March 15, 2020): 97–120. http://dx.doi.org/10.25726/worldjournals.pro/wej.2020.1.5.

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Мониторинговые исследования за растительными объектами позволяют получить массив данных по особенностям роста, фенологии, развитию генеративных органов, характеру плодоношения, качеству семян, устойчивости к стресс-факторам, т.е. по показателям, которые находятся в функциональной зависимости между собой и позволяют судить о степени экологической пластичности растений. Для обоснования перспективности видов рода Juniperus, дальнейшего прогнозирования уровня адаптивности видов за пределами естественного ареала необходима достоверная и актуальная информация об успешности адаптации интродуцентов в

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Tornielli, Giovanni Battista, Marco Sandri, Marianna Fasoli, et al. "A molecular phenology scale of grape berry development." Horticulture Research, March 15, 2023. http://dx.doi.org/10.1093/hr/uhad048.

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Abstract Fruit growth and development consist of a continuous succession of physical, biochemical, and physiological changes driven by a genetic program that dynamically responds to environmental cues. Establishing recognizable stages over the whole fruit lifetime represents a fundamental requirement for research and fruit crop cultivation. This is especially relevant in perennial crops like grapevine (Vitis vinifera L.) to scale the development of its fruit across genotypes and growing conditions. In this work, molecular-based information from several grape berry transcriptomic datasets was e

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Delfino, Pietro, Sara Zenoni, Zahra Imanifard, Giovanni Battista Tornielli, and Diana Bellin. "Selection of candidate genes controlling veraison time in grapevine through integration of meta-QTL and transcriptomic data." BMC Genomics 20, no. 1 (2019). http://dx.doi.org/10.1186/s12864-019-6124-0.

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Abstract Background High temperature during grape berry ripening impairs the quality of fruits and wines. Veraison time, which marks ripening onset, is a key factor for determining climatic conditions during berry ripening. Understanding its genetic control is crucial to successfully breed varieties more adapted to a changing climate. Quantitative trait loci (QTL) studies attempting to elucidate the genetic determinism of developmental stages in grapevine have identified wide genomic regions. Broad scale transcriptomic studies, by identifying sets of genes modulated during berry development an

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Theine, Jens, Daniela Holtgräwe, Katja Herzog, et al. "Transcriptomic analysis of temporal shifts in berry development between two grapevine cultivars of the Pinot family reveals potential genes controlling ripening time." BMC Plant Biology 21, no. 1 (2021). http://dx.doi.org/10.1186/s12870-021-03110-6.

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Abstract Background Grapevine cultivars of the Pinot family represent clonally propagated mutants with major phenotypic and physiological differences, such as different colour or shifted ripening time, as well as changes in important viticultural traits. Specifically, the cultivars ‘Pinot Noir’ (PN) and ‘Pinot Noir Precoce’ (PNP, early ripening) flower at the same time, but vary in the beginning of berry ripening (veraison) and, consequently, harvest time. In addition to genotype, seasonal climatic conditions (i.e. high temperatures) also affect ripening times. To reveal possible regulatory ge

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Zhang, Fuchun, Haixia Zhong, Xiaoming Zhou, et al. "Grafting with rootstocks promotes phenolic compound accumulation in grape berry skin during development by integrative multi-omics analysis." Horticulture Research, March 14, 2022. http://dx.doi.org/10.1093/hr/uhac055.

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Abstract In viticulture, grafting has been practiced widely and influences grape development as well as berry and wine quality. However, limited knowledge is present about the effects of rootstocks on grape phenolic compounds, which locate primarily in the berry skin and contribute to certain sensory attributes of wine. In this study, scion-rootstock interactions were investigated at green-berry stage and veraison stage when grapevines were hetero-grafted with three commonly used rootstock genotypes (5BB, 101-14MG, and SO4). The physiological investigations showed that hetero-grafts especially

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Ismail, Ahmed, Tariq Pervaiz, Stacey Comstock, et al. "Unraveling the occasional occurrence of berry astringency in table grape cv. Scarlet Royal: a physiological and transcriptomic analysis." Frontiers in Plant Science 14 (October 26, 2023). http://dx.doi.org/10.3389/fpls.2023.1271251.

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Scarlet Royal, a mid-season ripening table grape, is one of the popular red grape varieties in California. However, its berries develop an undesirable astringent taste under certain conditions. Among the various factors contributing to the degradation of berry attributes, the levels and compositions of polyphenols play a fundamental role in defining berry quality and sensory characteristics. To comprehend the underlying mechanism of astringency development, Scarlet Royal berries with non-astringent attributes at the V7 vineyard were compared to astringent ones at the V9 vineyard. Biochemical a

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Thole, Vera, Jean-Etienne Bassard, Ricardo Ramírez-González, et al. "RNA-seq, de novo transcriptome assembly and flavonoid gene analysis in 13 wild and cultivated berry fruit species with high content of phenolics." BMC Genomics 20, no. 1 (2019). http://dx.doi.org/10.1186/s12864-019-6183-2.

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Abstract Background Flavonoids are produced in all flowering plants in a wide range of tissues including in berry fruits. These compounds are of considerable interest for their biological activities, health benefits and potential pharmacological applications. However, transcriptomic and genomic resources for wild and cultivated berry fruit species are often limited, despite their value in underpinning the in-depth study of metabolic pathways, fruit ripening as well as in the identification of genotypes rich in bioactive compounds. Results To access the genetic diversity of wild and cultivated

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Tornielli, Giovanni Battista, Ron Shmuleviz, Alessandra Amato, et al. "Scaling the grape berry developmental stage by molecular phenology: Application details and caveats." PLANTS, PEOPLE, PLANET, April 14, 2025. https://doi.org/10.1002/ppp3.70018.

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Societal Impact StatementGlobal climate change is adversely affecting grape quality by accelerating developmental processes. We developed an advanced method to define grape berry phenological stages based on gene expression information and made it accessible for widespread research. By precisely identifying these growth stages we can improve our understanding of how environmental conditions and agricultural practices influence grape quality. This has significant implications for developing mitigation strategies in viticulture and emphasizes the need for adaptive policies that can sustain grape

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Villano, Clizia, Olivia Costantina Demurtas, Salvatore Esposito, et al. "Integrative analysis of metabolome and transcriptome profiles to highlight aroma determinants in Aglianico and Falanghina grape berries." BMC Plant Biology 23, no. 1 (2023). http://dx.doi.org/10.1186/s12870-023-04251-6.

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Abstract Background The biochemical makeup of grape berries at harvest is essential for wine quality and depends on a fine transcriptional regulation occurring during berry development. In this study, we conducted a comprehensive survey of transcriptomic and metabolomic changes occurring in different berry tissues and developmental stages of the ancient grapes Aglianico and Falanghina to establish the patterns of the secondary metabolites contributing to their wine aroma and investigate the underlying transcriptional regulation. Results Over two hundred genes related to aroma were found, of wh

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Wei, Lingzhu, Jianhui Cheng, Jiang Xiang, and Jiang Wu. "Genome-wide identification and characterization of grapevine UFD1 genes during berry development and salt stress response." Journal of Plant Biochemistry and Biotechnology, January 27, 2022. http://dx.doi.org/10.1007/s13562-021-00742-5.

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AbstractGrapevine (Vitis vinifera) is widely applicated in food industry, which shows high economical and nutritional values. However, growth of grapevine was usually affected by various environmental stresses, such as salt, drought and disease. Ubiquitin fusion degradation protein 1 (UFD1) is an essential ubiquitin-recognition protein facilitates regulation of stress response through ERAD pathway. Even though, a comprehensive investigation of UFD1 genes in the plant species is still lacking. Here we identified three VvUFD1 proteins from genome of grapevine, which were assigned into different

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Niederauer, Guilherme Francio, Geovani Luciano de Oliveira, Alexandre Hild Aono, et al. "Uncovering the molecular mechanisms of russet skin formation in Niagara grapevine (Vitis vinifera × Vitis labrusca)." Scientific Reports 14, no. 1 (2024). http://dx.doi.org/10.1038/s41598-024-55745-8.

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AbstractGrape breeding programs are mostly focused on developing new varieties with high production volume, sugar contents, and phenolic compound diversity combined with resistance and tolerance to the main pathogens under culture and adverse environmental conditions. The ‘Niagara’ variety (Vitis labrusca$$\times$$ × Vitis vinifera) is one of the most widely produced and commercialized table grapes in Brazil. In this work, we selected three Niagara somatic variants with contrasting berry phenotypes and performed morphological and transcriptomic analyses of their berries. Histological sections

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Liao, Yi, Kaiji Chen, Xiaoqiang Su, et al. "Independent Phase Control in Gap‐Tuned Metasurfaces for Dual‐Function Switching." Laser & Photonics Reviews, May 9, 2024. http://dx.doi.org/10.1002/lpor.202400100.

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AbstractSeeking new ways to actively control the phase using metasurfaces has gained significant attention in recent years, which is the key to achieve controllable wavefronts under external stimuli. Among various active phase control mechanisms, a mechanical method based on gap tuning, termed as gap‐tuned metasurface here, has shown promise in continuous phase adjustment. However, previous studies face limitations in independent and complete phase control at different gap distances, which is crucial in dual‐function switching applications. In this study, a novel type of gap‐tuned metasurfaces

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