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Shinomiya, Mitsuyoshi. "Google Bespoke!" Thesis, Umeå universitet, Designhögskolan vid Umeå universitet, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-98043.
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In my master thesis, I decided to focus on process of design. Nowadays, there is huge difference between the process of software design and hardware design due to technological problem. Software design development has more flexibility than hardware design development. In addition, it can be adjustable for each user and can involve user in design process. In the future, some of technology such as 3D printer, modifiable material, and so on, will enable hardware designer to use software design process to design hardware. The process can make better relation between user and product. In this thesis, I used real user to simulate the future process. I did a lot of interview to the user and involve him to design process. I used current technology to interact with user as much as possible, for example, I used 3D scanner to scan his body data to make perfect size reference for his vehicle. In the end, I could design something unexpected in good way thanks to collaboration with the user. It was also unexpected for him, but he was satisfied with the result so much. I believe this process has a lot of potential to make better relation and story between user and product.
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Webb, Oliver A. "Bespoke container molecules for fuel additives." Thesis, University of Surrey, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606795.
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The findings of the first reported guest centric encapsulation study are presented within. The guests were of interest as petrol and diesel (fuel) additives, with the focus on 2-ethylhexyl nitrate (2-EHN), di-tert-butyl peroxide (DTBP), aniline, N-methylaniline (NMA) and N,Ndimethylaniline CNNDMA). Complexation with 2-EHN and DTBP was achieved with the novel calix[4]arene derivative, 5, 11, 17, 23-tetra-tert-butyl, 25, 27-bis(oxyethylphenylurea), 26, 28-dihydroxycalix[4}arene, CA(III). This was confirmed in solution by the use of NMR techniques. The multi-step procedure to yield a tetrol cavitand. with recent updates to the procedures are fully described. A new carceplex system with aniline encapsulated, carceplex aniline (4, 24- 5,5'- 6,10- 11 , 11'- 12, 16- 17, 17'- 18, 22- 23, 23'- 4', 24'- 6',10'- 12', 16'- 18 ',22' dodecamethylenedioxy, 2, 8, 14,20, 2', 8' ,14', 20'-octapentyl-bis-calix[4]arene aniline) was produced in a pioneering pressure tube encapsulation follwing unsuccessful attempts under reflux conditions. A pyrogallol[4]arene with pentyl pendant group (2, 8, 14, 20-tetrapentylpyrogallol[4]arene) PA(I) was synthesised and successfully employed for self-assembled complex formation with aniline, NMA and NNDMA. These complexes were found to be stable in polar and apolar media at 313 K over a duration of 2 months. The complexes were of stoichiometry 10:1 (aniline: PA(I)), 12:1 (NMA : PA(I)), and 4:1 (NNDMA: PA(l)). Significant variation was observed when complexes were analysed by TGA in air up to 800 °C compared to control. PA(I) . aniline and PA(I) . NMA displayed solubilities in apolar media making them suitable for analysis in test engines as fuel additives. The first report of a (two-step) carcerand synthesised from pyrogallol[4]arene, PA(I) with the introduction of methylene dioxy spanning and bridging groups, yielding the novel carcerand 4,24- 5, 4'.- 6, 5' - 10, 1\ ' - 12, 16- 17, 16'- 18, 17'- 22, 23'- 23, 24' - 6', 10'- 18', 22' dodecamethylenedioxy, 2, 8, 14, 20, 2', 8', 14', 20' -octapentyl-bis-calix[4]arene is also presented.
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Kang, Dilbir. "A capacity planning system for bespoke manufacturing." Thesis, University of Huddersfield, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293378.
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The majority of the commercially available systems developed for capacity planning have been designedf or organisationsw hich are involved with make-to-stockm anufacturingT. heses ystemsa re difficult to implementi n bespokem anufacturing( make-to-ordero) rganisationss ince they are unable to accommodateth e requirementso f the volatile productione nvironment. This thesisi dentifies the uniqueo peratingc haracteristicos f the manufacturinge nvironmenta ssociated with bespokem anufacturingw hich caused ifficulty with the implementationo f commerciallya vailable systemsT. he findings from this investigationa re usedt o formulatea design for a capacityp lanning systemw hich fulfils the unique requirementso f the bespokem anufacturinge nvironment. The proposed system executes the capacity planning function at two separate levels of detail by integrating rough cut capacity planning with finite capacity planning. The two planning mechanisms are also integrated with a shop floor data collection system which has been designed for the assembly environment. Data interaction is achieved between the capacity planning modules and the shop floor data collection system via an Interface ManagemenSt ystem which ensurest hat the scheduled ata containedi n the individual systemsr emainsi n synchronisationa t all times. The capacity planning system also includes the design and development of a large scale display facility which is able to accommodateth e large volume of scheduled ata required to be viewed for finite capacity planning. This facility has been designed using multiple co-ordinated screens which are linked by a local area network. A data interface and parallel processing facility is incorporated in the design which enable the processing of a software application to be distributed over multiple nodes.
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Hume, David L. (David Luke). "Managing expectations during acquisition of bespoke automation systems." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104287.
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Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016. In conjunction with the Leaders for Global Operations Program at MIT.Thesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, 2016. In conjunction with the Leaders for Global Operations Program at MIT.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 69-73).
A new facility seeks to manufacture inlets for the turbine of the new NDA aircraft. The inlet is a new design and has never been built before. To complicate matters the manufacturer, Aeron 2 Company, has not traditionally produced any inlets, let alone at the expected production rates for the new aircraft that already has thousands of orders. It was decided that in order to meet demand production must be automated in a similar way to the automotive industry. Aeron, and the commercial aerospace industry as a whole, are inexperienced with automation systems and they believed that they lacked the in-house knowledge to develop and integrate their own automated system. They entered into a contract with a robotics integrator that is has traditionally operated within the automotive industry for delivery of a "turnkey" system. This research covers a six-month period that overlaps with the beginning of Factory Acceptance Testing (FAT) of the automated assembly line. Initial observations hinted at the possibility of a strained relationship between Aeron and its automation integrator. This thesis sought to understand if the relationship was indeed strained, and if so, what were the causes and could it be improved? The Aeron group most involved with this system purchase, referred to as TWS, is used as a case-study to investigate the different factors that can affect an interorganizational relationship during development of a technically complex system. The research and recommendations can be applied to other companies that are involved in inter-organizational relationships founded upon development of technically complex projects. An inductive-deductive iterative approach was used in three phases to conduct this research. Beginning with background research in phase one an inductive approach is used to develop a qualitative model of the inter-organizational system. This model leads to additional questions regarding inter-organizational relationships and their more important factors, such as expectations and trust; namely, what are the expectations that are held by each party in the relationship and what are their impacts? These additional questions are addressed in a deductive manner in phase two. Through the use of surveys sent to different automation teams across the organization, data was collected that reflected the different relationships. These survey results indicate interesting customer perceptions of their respective automation suppliers. At the time of this writing all of the automation projects are perceived to be technically complex, yet some contractors are perceived as more technically capable than others. These data also indicate a general lack of trust. Expectations are addressed using a simple matrix that outlines the different technical and management expectations held by TWS in regards to the equipment being purchased and their integrator. A number of expectations held by TWS are unrealistic and have, as of this writing, gone unfulfilled. The third and final phase revisited the initial model in phase one and made modifications based on findings from phase two. For technically complex projects, such as the development of an automated assembly line using immature technology to build a new product, it is impossible to capture every design specification for the system. Design changes will occur. It is imperative that correct expectations regarding the equipment and the firm's capabilities are correctly set at the beginning of the project to reduce a shortfall in expected performance versus actual performance. Expectations, including those that are unrealistic, that go unfulfilled lead to decay in trust. This decay in trust in turn leads to a decreased likelihood in project success. It is recommended that Aeron shy away from "turnkey" systems for such state-of-the-art projects in the future, or at least until Aeron becomes more familiar with automated assembly and their integrators become more familiar with aerospace requirements. This research is most applicable to commercial aerospace companies entering a formal relationship with an automation integrator for an automated assembly line. The research does have general recommendations that are applicable to other industries engaging in similar endeavors. Future work would include a lifecycle study of trust levels within an interorganizational relationship and how they change over the course of the project from conception to delivery.
by David L. Hume.
S.M.
M.B.A.
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Hardy, Martin Charles. "Control logic evaluation of bespoke computer controlled machine tools." Thesis, University of Huddersfield, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359143.
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Wnek, Malgorzata. "Use of chimeric TMV coat proteins to fabricate bespoke nanowires." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522915.
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Miller, Erin. "The art of collaboration : creating bespoke therapy with the client." Thesis, City University London, 2011. http://openaccess.city.ac.uk/1148/.
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Introduction Living with HIV has been described as a process of constant adjustment and re-adjustment as the person attempts to create both a good quantity and quality of life (Pierret, 2000). Most of the literature from the counselling psychology community has focused on the efficacy of cognitive behavioural therapy for this client group however; some of the theory behind this model has been questioned in relation to the needs of the HIV positive community. The current study explored the process between three HIV positive clients and twelve sessions of pluralistic therapy. Method Twelve pluralistic therapy sessions with three HIV positive clients were audio recorded. The participants were recruited from the waiting list of a specialist HIV mental health service in London. Grounded theory strategies were used to analyse the transcriptions of the therapy sessions. Feedback sessions were also conducted with each of the clients in order to gain insight into their experience. The client work and analysis is presented in three pragmatic case studies. Results Goals: These HIV positive clients had specific ‘relational goals’ for therapy. More specifically, the goal was to have the experience of being the ‘expert’ in the room. Tasks: A common theme was ‘self care’ and increasing quality of life. Methods: The therapeutic relationship was found to be a method within the pluralistic framework. A common element for all three clients was the absolute importance placed on ‘creating a shared understanding’ between the client and the therapist.
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Wagner, Daniel Scott. "Improving Bespoke Software Quality: Strategies for Application and Enterprise Architects." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3843.
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Despite over 50 years of software engineering as a formal practice, contemporary developers of bespoke software follow development practices that result in low-quality products with high development and maintenance costs. This qualitative case study sought to identify strategies used by software and enterprise architects for applying architectural best practices to improve bespoke software quality and lower the total cost of ownership. The study population was application and enterprise architects associated with delivering bespoke software for the enterprise architecture team at a large enterprise in the Nashville, Tennessee metropolitan area. Interview data were collected from 7 enterprise or solution architects; in addition, 47 organizational documents were gathered. Guided by the principles of total quality management, thematic analysis was used to identify codes and themes related to management of quality in software solutions. Prominent themes included focusing on customer satisfaction, collaborating and communicating with all stakeholders, and defining boundaries and empowering people within those boundaries. The findings from this research have implications for positive social change, including improved work-life balance, morale, and productivity of software and enterprise architects through streamlining development and maintenance activities.
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Sarabia, Jose Raul Salas. "Human Crafted : A Vehicle as a Celebration of Humanity." Thesis, Umeå universitet, Designhögskolan vid Umeå universitet, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-149736.
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With smart machines taking over each time more tasks, there is a risk of a future without relevant field for human action. In the 19th Century, the Arts and Crafts movement proposed a reaction against the alienation generated by industrial machines. Today, following the spirit of Arts and Crafts, this project intends to pose a reaction against the aesthetics of Artificial Intelligence by embracing human-crafted methods. Furthermore, to tell a complete story of humanizing experiences, the production and use of the vehicle are focused on human interaction; in the first case as a bespoke process and in the second as a vehicle interior that fosters human interaction. With Rolls-Royce Bespoke Design as collaborator for this thesis, the project has been branded after them, taking advantage of the company's hand-crafted approach as a positive value with humanistic potential. The main inspiration consisted of a reinterpretation of traditional artisan methods in order to design a vehicle with novel attributes. In contrast to the common practice of vehicle design where the generation of geometry rules the latter selection of materials and production process, for this project the early inspiration from hand-crafted methods dictated material and form, which could result in limitations during the form finding process, but which could also trigger unexpected results. At the same time, the simulation of the bespoke process with a relevant individual playing the role of the product's user had a major influence on the final outcome. The final result is a vehicle in which the main design focus lies on the interior, although the exterior had to be developed to some extent to provide a frame for development of the inside. The main design contribution is the proposal of structural elements with an aesthetic intention which was dictated by material properties and authenticity. As a story, the project intends to question the increasing presence of Artificial Intelligence and what could be an appropriate scenario for its usage (i.e. autonomous drive algorithms enabling human interaction inside the vehicle). So with the goal of providing humanizing experiences for makers and users of the product, even overlapping the role of makers and users during the bespoke process, the project tells a story of humanization through craftsmanship and dialogue.
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Foster, Richard. "Improvement of movement function using bespoke virtual reality based computer games." Thesis, Liverpool John Moores University, 2012. http://researchonline.ljmu.ac.uk/6176/.
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Children with cerebral palsy suffer from primary abnormalities that affect their ability to control movement of body segments. There is evidence that the core (trunk and pelvis) of the body activates prior to the periphery (extremities) during human movement, and so improvement in controlling the core first, then the periphery, could lead to carrying out activities of daily living more effectively. Virtual rehabilitation is developing as a method for the training and assessment of movement function, with evidence suggesting games controlled by the periphery can lead to improvements in activities of daily living, but virtual rehabilitation on the core is scarce. Study One (feasibility study) assessed the changes in gait in response to a six week virtual reality intervention training the core in children with cerebral palsy diplegia (n = 5), using a laboratory based virtual reality system. Improvement in selective motor control of the core occurred after VR training, represented by increased VR game performance (maximum settled speed). Participants showed that single plane trunk movement was better controlled than cross plane trunk movement, trunk rotation was better controlled than trunk tilt, and the trunk was controlled better than the pelvis. Changes in game performance did not transfer to improvements in gait as measured using the Gait Deviation Index. Study Two used a portable virtual reality system in primary schools to train the core and periphery in children with cerebral palsy. A randomised, cross-over design on children with cerebral palsy (n = 8) found that VR game performance improved after receiving VR training, represented by an increase in maximum settled speed and a reduction in variation of pass distance. Single plane movement of the trunk was better controlled than cross plane movement during each assessment, ankle control was better than knee control at each assessment, and control of peripheral segments was better than control of core segments. There were no significant differences in performance of the sit -to-stand movement in response to core training (one week) followed by peripheral training (one week), or when training order was reversed. Overall, Study One and Study Two found no improvements in activities of daily living. Low levels of exposure to virtual reality training, inappropriate outcome measures, in addition to low sample sizes, may have reduced the effect on performance of activities of daily living. Study Two demonstrated that portable virtual reality training is feasible in schools, and can be provided on a daily basis to children with movement difficulties. Overall, the findings provide an important insight into virtual reality training aimed at improving control of the core and periphery in children with cerebral palsy.
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Griffin, Carl James. "As lated tongues bespoke : popular protest in south-east England, 1790-1840." Thesis, University of Bristol, 2001. http://hdl.handle.net/1983/6640a09a-72d5-44a5-8c66-c952ecde4085.
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Bergström, Jonas, and Andreas Dahlqvist. "BESMART : a framework for shifting from BESpoke to MARkeT-driven requirements engineering." Thesis, Blekinge Tekniska Högskola, Avdelningen för programvarusystem, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-1308.
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Requirements Engineering has two main directions, Bespoke (product developed for one customer) and Market-Driven (several potential customers for the same product). These two are in some ways very much alike but in some aspects very different. Over the last couple of years the software development industry has tended to shift more and more to Market-Driven Requirements Engineering. This has brought attention to the challenges facing a Market-Driven development organization, without focusing on the actual shift from Bespoke development. Based on the differences and similarities between Bespoke and Market-Driven Requirements Engineering, this thesis presents a framework for shifting from the former to the latter. The framework (BESMART) involves three steps. Firstly, the organization assesses their potential to become more Market-Driven. Secondly they assess their current way of working to identify which areas that may need to be improved. Finally, BESMART provides multiple suggestions that address the identified improvement areas. The organization is then able to choose the one that best suits their needs. This also lets the organization choose a solution that they find feasible. The framework was used at a case organization during its development. This way it was ensured that the theoretical framework could actually be used in a real world setting. The practical use of BESMART resulted in some refinements aimed at making it more applicable in industry. Once the framework had been applied, it was evaluated by representatives from the case organization. The industry evaluation resulted in some improvement suggestions but showed that the framework was both useful and usable and provided an improvement plan that seemed promising enough to pilot in the organization.
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SILVA, MARCELO ALMEIDA DE CARVALHO. "WORKER BESPOKE? A CRITICAL ANALYSIS OF THE DISCOURSE OF A BUSINESS MAGAZINE ABOUT COMPETENCES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2014. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=23606@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIROCOORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
O objetivo desta pesquisa é investigar o discurso de uma popular revista de negócios no Brasil – Você S. A. – sobre as competências necessárias para o ingresso, manutenção e ascensão dos indivíduos no mundo corporativo. Para alcançar esse objetivo, foi possível problematizar as relações de poder e de dominação presentes no atual cenário de precarização das relações de trabalho, onde os indivíduos precisam, cada vez mais, se submeter aos critérios de qualificação impostos pelo mercado. Assume-se na pesquisa, que servindo como mediador entre esses profissionais e as empresas, as mídias de negócio procuram divulgar as competências que o mercado demanda e, de forma prescritiva e instrumental, oferecer dicas e conselhos com o intuito de desenvolver tais habilidades. Tendo em vista este papel preponderante, buscou-se compreender também as diretrizes ideológicas que norteiam este discurso. Para fundamentação teórica foi feita uma revisão da literatura sobre competências, mercado de trabalho contemporâneo, mídia de negócios, discurso, ideologia e poder. As fontes foram obtidas por meio de pesquisa documental de cunho qualitativo, que abrangeu cinco anos de publicação da revista Você S. A. perfazendo um total de 70 edições e 101 reportagens. Para identificação das competências, foram categorizados 16 objetos discursivos que compõem seis formações discursivas. O método de análise foi a Análise Crítica de Discurso. Os resultados obtidos sugerem a existência de um viés ideológico no discurso da revista - que procura submeter as competências do indivíduo às demandas do mercado, agindo como controle ideológico sobre os trabalhadores - consubstanciadas em quatro ordens de discurso.
The objective of this research is to understand the discourse of one popular magazine business in Brazil – Você S. A. - on the theme competencies to enter, to keep and ascension of individuals in corporate market. To achieving that goal, it was possible to problematize the relations of power and domination present in today s precarious labor relationships, where individuals need ,increasingly , to submit the eligibility criteria imposed by the market . It is assumed in research serving as a mediator between these professionals and the firms, the media business try to justify the skills demanded by the market, and prescriptive and instrumental way, offering tips and advice in order to achive such skills . Given this important role, we sought to understand the ideological guidelines by which this discourse. Theoretical foundation for this study was based in a review of the literature about on competencies, contemporary labor market ,business media , discourse , ideology and power. The data sources were obtained through documentary qualitative research, which covered five years of publication of the magazine Você S. A. for a total of 70 editions and 101 reports .For identification of competencies were categorized 16 discursive objects that comprise six discursive formations. The analysis method was the Critical Discourse Analysis.The results obtained suggest the existence an ideological bias in the discourse of the magazine - which in the intent of submitting the individuals competencies to the market demands acting as ideological control over workers - represented by four orders of discourse.
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Paulson, Christopher A. "The rapid development of bespoke sensorcraft : a proposed design loop for small unmanned aircraft." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/412645/.
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The ability to quickly fabricate small unmanned aircraft through additive manufacturing methods opens a range of new possibilities for the design and optimisation of these vehicles. In this thesis, we propose a design loop that makes use of surrogate modelling and additive manufacturing to reduce the design and optimisation time of scientific small unmanned aircraft. Additive manufacturing reduces the time and effort required to fabricate a complete aircraft, allowing for rapid design iterations and flight testing. Co-Kriging surrogate models allow data collected from test flights to correct Kriging models trained with numerically simulated data. The resulting model provides physically accurate and computationally cheap aircraft performance predictions. A global optimiser is used to search this model to find an optimal design for a bespoke aircraft. We apply the proposed design loop in a real-world case study. A parameterised joined wing aircraft is optimised to fulfil the mission requirements of a sensorcraft, or a small unmanned aircraft capable of carrying a payload of scientific sensors. Following the proposed design loop, three parametric aircraft were fabricated using additive manufacturing and flight tested. These flight testing data were used to construct a co-Kriging surrogate model capable of being used for the rapid optimisation of future sensorcraft.
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Tarrini, Mauro G. "The Development and application of a bespoke organisational learning competency framework in a global organisation." Thesis, Cranfield University, 2004. http://hdl.handle.net/1826/113.
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Organisational Learning has been conceptualised and measured in various ways. The two studies reported in this thesis sought to take a new, bespoke approach to Organisational Learning in a global air transport company undergoing substantial organisational and strategic change. The research sought to develop a bespoke competency framework of Organisational Learning and apply it within the organisation to investigate employees' perceptions of the Organisational Learning climate. The research applied both qualitative and qualitative methods: semi-structured interviews and a 68-item self-completion questionnaire survey. Factor Analysis yielded a clear, conceptually sound six-factor solution. Organisational Learning climate perceptions were compared across occupational, departmental and geographical subgroups. The results indicated that there were no statistically significant occupational or geographical differences in perceptions of the Organisational Learning climate although some departmental differences were observed. The relationaship between perceived Organisational Learning climate and organisational commitment was explored and a clear link between them was found.
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Imperiale, Vita. "Design and formulation of a bespoke self-healing agent for repair of multifunctional fibre reinforced polymers." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582821.
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The aim of this investigation was to design a bespoke self-healing agent (SHA) formulation in order to achieve a fully autonomous healing functionality, which provides effective and timely in-situ repair of FRP composite laminates. The preliminary phase of the design process consisted of the identification of the SHA requirements, the choice of epoxy resins as the most suitable chemistry and, finally, the selection of the best candidate species, amongst the many commercially available. Numerous formulations were then generated by the combination of the above components. Therefore, an initial downselection process, with chemical and physical properties characterisation was necessary to consider only a limited number of formulations for mechanical properties characterization. A Mode I fracture toughness test was considered as a means of final selection, the adhesive function being one of the most important functional requirements. Finally, the recovery of residual compressive strength after impact (CAI) was used as a validation method, which was able to demonstrate and quantify the self-healing recovery within a FRP laminate. A very low viscosity epoxy based formulation with a slightly higher fracture toughness than the host composite matrix and good degree of reactivity was selected as having the best overall performance. Adhesion, as a function of time and temperature, was further assessed in this formulation. It was demonstrated that a certain degree of load bearing ability can be achieved after limited reaction extent with full recovery of load bearing ability after 6 hours at 25°C. An ageing assessment of SHA demonstrated that after seven days exposure to 60°C the formulation possessed excellent adhesive properties. The novel integration of a two-part SHA, with the components segregated within different hollow glass fibres for a fully autonomous process, required the development of a suitable manufacturing and design of the FRP laminate. The damaged and self-healed samples achieved 93% of the strength relative to the initial pristine configuration. Besides an increase in the failure load, self-healing generated a significant change in the stress-strain characteristics, which restored a degree of linearity up to failure, and a reduction in the differential strains (and hence increased buckling resistance). The bleeding of the SHA from storage in the HGF to effect healing can be implied from ultrasonic C-scan analysis, where images of self- healing samples possessed fragmented and less defined delamination contours compared to the image of damaged samples without SHA within hollow glass fibres. This investigation has demonstrated that a fully autonomous recovery of a significant proportion of compressive strength in a CFRP is possible via self-healing. For the first time it has been demonstrated that a bespoke multi-component SHA is able to bleed from embedded HGF, self-mix and react to allow recovery of up to 93% of compressive strength, notwithstanding the presence of remaining damage within the CFRP laminate
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Sandell, Ludvig. "Henry Poole & Co. : How a 200-year old bespoke tailor have managed to stay modern." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-12839.
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Background: During the last decade or so the century old bespoke tailors on Savile Row have become the epitome of luxury brands as far as menswear is concerned. At the same time, the different establishments on Savile Row have started to modernise themselves through various means to better fit into today’s fast paced retail-market. Aims of the research: The purpose of this research is to discover what factors have played part in keeping the founders of Savile Row, Henry Poole & Co., modern and relevant throughout the years. Methods: This research was conducted as a qualitative single case, case study. The data was gathered through semi-structured interviews with upper management and other available published sources and then analysed with the help of former research in relevant areas. Results: It was found that the brand of Henry Poole & Co. stayed true to their origins as a bespoke tailor and that modernising is something that has not been forced upon the company and brand but should more be seen as a continuous process where each new generation bring something new to the company. The company had adapted modern ways of communication such as social media and a responsive website and also incorporated step down line extensions, where they sell ready-to-wear and made-to-measure garments in China and Japan. This is a way to develop their brand into other segments but they still kept their original brand vision intact as being a pure bespoke tailor located on Savile Row and kept their different business operations on a distance. Contributions: This thesis has opened up doors to an area that has not had much interest from the academic world. It hopefully gives way for new research ideas, but it has also highlighted management tools and best practices that has contributed to the success of a more than two century old company.
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Ivarsson, Adam. "Expediting Gathering and Labeling of Data from Zebrafish Models of Tumor Progression and Metastasis Using Bespoke Software." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148691.
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In this paper I describe a set of algorithms used to partly automate the labeling and preparation of images of zebrafish embryos used as models of tumor progression and metastasis. These algorithms show promise for saving time for researchers using zebrafish in this way.
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Michalakos, Christos Georgios. "Evolving the drum-kit : frameworks and methods for diachronic live electronic performance practice and bespoke instrument design." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/16178.
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This thesis examines performance practice with the Augmented Drum-Kit, a personal evolution of the acoustic drum-kit with the use of digital technology. The practice is investigated from three perspectives: First, through possible spatial and contextual definitions of the instrument under development, taking into consideration the inherently open-ended nature of its building blocks: percussion and the computer. Second, by exploring the composer/performer/builder’s practice paradigm in terms of musical and performative goals with such an emerging performance environment. Finally, as a diachronic practice between performer and all constituent technological parts of the composite instrument, towards the practice’s ongoing development and evolution. Using these discussions as starting points, this practice-led research proposes three intertwined novel frameworks for diachronic live electronic performance practice and bespoke instrument design. Additionally, the developed instrument itself is detailed in the form of the devised design methods, schematics, diagrams and software, addressing questions such as intuitive control, gestural uniformity, consistent electro-acoustic vocabulary, distinct instrumental character, mobility, sound diffusion and transferability. Finally, music portfolio consisting of five solo and group album recordings with the Augmented Drum-Kit is presented, while audiovisual examples from various scenarios and development stages are used to further illustrate the discussion.
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Menküc, Benjamin Sefa [Verfasser]. "Development of a bespoke algorithm to analyze ChIP-nexus genome-wide protein-DNA binding profiles / Benjamin Sefa Menküc." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1126503746/34.
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Bishop, David. "Bespoke nanotopography for the selective capture of VWF from whole blood at arterial shear : a potential diagnostic platform." Thesis, Ulster University, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.714499.
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The concept of surface mediated protein manipulation is well utilised throughout many diagnostic and therapeutic applications. Tailoring of surface chemistry, wettability and topography can facilitate targeted adherence of specific proteins for desired biological outcomes, von Willebrand Factor (VWF) is a key hemostatic blood protein that modulates platelet response at high arterial shear rates following vascular damage. Defective interaction of VWF and platelets is a fundamental risk factor for both thrombogenic events and bleeding disorders, depending on the nature of the defect. However, there is currently no physiologically relevant diagnostic platform operable under such conditions. The work reported in this thesis concerns augmentation of an existing Dynamic Platelet Function Assay (DPFA) with substrate surface topography capable of entrapment of autologous VWF from whole blood flowing at typical arterial shear rate (1500s1). These novel substrates are employed as part of a microfluidic platform for real-time fluorescent imaging of platelets. The adhesion and activity of which are indicative of VWF entrapment/function and how this relates to a diseased state. The primary substrates of interest have been created via spin coating of PMMA/PS polymer demixed solutions in chloroform. Polymer concentration is the chief variable utilised in the optimisation of topographical conditions for VWF capture, with PMMA:PS ratio and molecular weight investigated also. Concentrations of 1 %, 3 % and 5% w/v were employed, with the middle state (3%) proving the best performer in terms of both rate and total amount of platelet surface coverage; an average of 40% in comparison with 27% and 19% for the 1% and 5% concentrations respectively. Interestingly, these substrates exhibit a lag time in initial platelet response, not present on the immobilised VWF controls. This is thought to be a consequence of the time taken to accumulate a sufficient quantity of captured VWF for inciting platelet interaction. Inhibition studies, with antibodies that target the VWF-platelet binding pathway, confirmed the presence and action of autologous VWF in the platelet response. VWF supplementation of blood at 40 (ig/ml resulted in an increase in coverage of 25% when compared to untreated controls (38% and 13% respectively). XPS analysis revealed a stable PMMA chemistry (P>0.05) across all surfaces. Water contact angle (WCA) analysis showed an average value of 69° for surfaces prepared using all three concentrations, which compares to 72° for pristine PMMA. Optical microscopy revealed a hugely changeable morphology across the concentrations, related to interconnectivity, whilst AFM revealed the presence of two discrete layers of topography; a larger mesotopography consisting of a pitted morphology with feature heights ranging from 90 to 502 nm, overlaid by a nanotopography with pillared features averaging in the 10 to 50 nm height range. It is the presence of this nanotopography, which is hypothesised to be the primary mechanism of VWF capture. NIL was employed for the replication of the nanotopography in a more reproducible fashion. A stamp template was designed using the AFM data and used to generate channels with av. feature heights in the range of 40-47 nm. A loading pressure of 7.5kN was found to produce well-rounded features with av. height of 47 nm. Similar topographical features were created via spin coating with a 3% 75:25 PMMA:PS demixed solution with av. feature heights of 45 nm, which triggered good platelet adhesion thereby confirming its ability for VWF entrapment. Finally, a preliminary investigation of collagen integration to the novel substrates is reported. This approach involves a novel plasma assisted printing methodology to create a highly physiologically relevant hemostatic diagnostic platform.
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Ahmed, Israr, and Shahid Nadeem. "Minimizing Defects Originating from Elicitation, Analysis and Negotiation (E and A&N) Phase in Bespoke Requirements Engineering." Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-4070.
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Defect prevention (DP) in early stages of software development life cycle (SDLC) is very cost effective than in later stages. The requirements elicitation and analysis & negotiation (E and A&N) phases in requirements engineering (RE) process are very critical and are major source of requirements defects. A poor E and A&N process may lead to a software requirements specifications (SRS) full of defects like missing, ambiguous, inconsistent, misunderstood, and incomplete requirements. If these defects are identified and fixed in later stages of SDLC then they could cause major rework by spending extra cost and effort. Organizations are spending about half of their total project budget on avoidable rework and majority of defects originate from RE activities. This study is an attempt to prevent requirements level defects from penetrates into later stages of SDLC. For this purpose empirical and literature studies are presented in this thesis. The empirical study is carried out with the help of six companies from Pakistan & Sweden by conducting interviews and literature study is done by using literature reviews. This study explores the most common requirements defect types, their reasons, severity level of defects (i.e. major or minor), DP techniques (DPTs) & methods, defect identification techniques that have been using in software development industry and problems in these DPTs. This study also describes possible major differences between Swedish and Pakistani software companies in terms of defect types and rate of defects originating from E and A&N phases. On the bases of study results, some solutions have been proposed to prevent requirements defects during the RE process. In this way we can minimize defects originating from E and A&N phases of RE in the bespoke requirements engineering (BESRE).
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Fatonade, Oluwakemi Victoria. "The application of knowledge based systems to the abstraction of design and costing rules in bespoke pipe jointing systems." Thesis, University of South Wales, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539334.
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Rodgers, Anthony David. "Bayesian inference from terrestrial gravimetry measurements of near-surface anomalies using a bespoke reversible-jump Markov chain Monte Carlo algorithm." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7493/.
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This work describes a Bayesian algorithm developed to tackle the problem of inference from two-dimensional grids of terrestrial gravity measurements. Near-surface voids such as pipelines and tunnels were the motivating application. The forward models used to approximate the gravity signal due to these potentially complex underground anomalies were sums of simple geometrical shapes: the sphere, finite horizontal cylinder and cuboid. The model parameters of these shapes are related non-linearly to the gravity signal. The reversible-jump Markov chain Monte Carlo algorithm was used, allowing changes to the number of objects comprising the forward model. The natural parsimony of the algorithm was shown to be key for obtaining depth information without the need for arbitrary regularisation. Exploring the Bayesian posterior distribution in this way, spatial, geometrical and anomaly mass information can be obtained as outputs from the inference process, given prior information regarding the soil-anomaly density contrast. This was demonstrated both with synthetic noisy gravity and gravity gradient data and with field gravity data obtained using the Scintrex CG-5 commercial gravimeter. The methodology used to obtain field survey data using the CG-5 over multiple days is described, with discussion of the assignment of measurement uncertainty. A 134 point measurement grid was taken above two spatially separate concrete anomalies, for which volume and density information were known. The data was input into the Bayesian inference algorithm, the forward model parameters were successfully inferred within the total uncertainty.
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Starr, Kim L. "Audio description and cognitive diversity : a bespoke approach to facilitating access to the emotional content in multimodal narrative texts for autistic audiences." Thesis, University of Surrey, 2018. http://epubs.surrey.ac.uk/848660/.
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Audio description (AD) offers untapped potential for delivering content to new audiences, particularly in the realm of cognitive accessibility. To date, bespoke AD orientations, moving beyond the standard blind and visually impaired modality (BVI-AD), have not been researched. This study explores the application of bespoke AD for emotion recognition purposes, from the perspective of individuals with autism spectrum disorders (ASDs) experiencing comorbid alexithymia (emotion recognition difficulties). It aims to establish the suitability of audio description as a vehicle for delivering emotion-based cues to assist with access to affective markers in film narrative. A study of AD for sight-impaired individuals undertaken by the British Broadcasting Corporation found evidence suggesting AD helped ASD individuals to engage with affective narrative (Fellowes, 2012). Studies of affect with autistic spectrum individuals commonly employ multimodal materials for the purposes of measuring emotion identification (Golan, Baron-Cohen & Golan, 2008), but have not yet incorporated supplementary AD, either as an entertainment or pedagogical resource. Addressing the gap, this project pairs AD remodelling techniques with an intervention study, to test for enhanced affective accessibility in ASD audiences. Applying a functionalist, skopos-based (Nord, 1997; Vermeer, 2012; Reiss & Vermeer, 2014) approach to modelling AD in the first phase of the study (S1), two new emotion recognition difficulties (ERD) modalities were developed, emoto-descriptive (EMO-AD) and emoto-interpretative (CXT-AD). These were subsequently tested, alongside standard (BVI) AD and a ‘zero’ AD modality (Z-AD), in an intervention study with young ASD individuals (S2). Results suggested that BVI-AD might represent a confound for this particular audience. Since ‘ceiling’ effect was observed in the other modalities (EMO-AD, CXT-AD and Z-AD), the efficacy of bespoke AD for emotion recognition applications remains unproven. However, the results indicate that affect-oriented AD, per se, is unlikely to confound ASD audiences. This study represents the first trial of tailor-made AD for audiences with cognitive accessibility needs, representing an interdisciplinary approach bridging the fields of audiovisual translation (Translation Studies) and psychology. As such, it opens up the debate for broader application of AD to aid accessibility in the cognitive arena.
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Wessels, Carina Helena. "To IOT or not IOT : a critical analysis of the key legal considerations applicable in internet of things of implementations in the mining industry." Diss., University of Pretoria, 2016. http://hdl.handle.net/2263/60113.
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The research introduces the fourth industrial revolution philosophically, exploring the application of innovation and automation in broad terms and the Internet of Things (IoT) specifically within the mining industry. It explains the business and societal motivation for such interventions, highlighting some of the key benefits. It further explores the inadvertent risks, some of which have already manifested in mining applications and others which can be inferred from other industrial and social applications.
A critical analysis is conducted of the application of the South African Mine Health and Safety Act and Regulations on such applications in the mining environment, as well as considering key other pieces of South African legislation. A comparative analysis with Australian legislation confirms that Western Australia has recognised the need for regulation and have started regulating, primarily mining automation, at least. Through these analyses it is established that a legislative vacuum exists, despite the general application of many requirements in relation to safety considerations during the utilisation of IoT applications.
The paper concludes by recommending collaboration between the Department of Mineral Resources and the Chamber of Mines to seek ways to lead legislative and regulatory developments in this space in order to enable the sustainability of the South African mining industry. In particular, the research suggests the emphasis should be to legally encourage and permit the implementation of IoT solutions in the mining industry in as many instances as reasonably possible, whilst consecutively addressing the new and emerging risks created through such.Mini Dissertation (LLM)--University of Pretoria, 2016.
Public Law
LLM
Unrestricted
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Kingston, Denise Jane. "A mixed methods study : evaluating the impact of a bespoke professional development based on an analysis of existing quality in one local authority." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1551541/.
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A four year quasi-experimental, repeated measures, mixed methods study was run in one Local Authority in England. Designed to improve early childhood quality and support policy development; it aimed to capture: first, the quality of all (279) pre-school settings within the county; second, the impact of a bespoke professional development (PD) on a sample of fifty private, voluntary and independent settings with matched controls. A database of quality, pre- and post- intervention, was established using Early Childhood Environment Rating Scales (ERS) [ECERS-R and E, (Harms et al., 2005; Sylva et al., 2003)], interviews, focus groups and questionnaires provided additional information. The PD was devised to support educators' implementing: • collaborative, evidence-based practice, • their role, including interpreting and using the Curriculum Guidance for the Foundation Stage (DfEE, 2000), • effective practice and research on: o the early Home Learning Environment, o children's behaviour for learning, o engaging with sustained shared thinking and o quality improvement processes. The PD data (ERS scores, focus groups, interviews and questionnaire responses) suggested that a short evidence-based PD can impact on practice predictably and consistently. Overall, quality ERS scores suggested the need for additional support and investment. Initial quality ratings (at pre-test) were predictive of modest improvements following the PD (at post-test). Ensuring the PD was accessible to all educators was an important part of the process. Where quality was extremely low at the beginning of the PD, no real progress was found, suggesting that this group of settings was unique and required more than the PD could offer. Bronfenbrenner's Bio-ecological Model of Human Development (2005) was applied to the educators' learning during the study. It supported: first, consideration of the interrelated multi-level systems that impacted on the educators' learning; and, second, the development of a new model considering the process of learning they underwent during the PD.
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Schwarz, Miriam Maria [Verfasser], Veit [Akademischer Betreuer] Wagner, Dietmar [Akademischer Betreuer] Knipp, Ulrich [Akademischer Betreuer] Kortz, and Klaus [Akademischer Betreuer] Schmidt. "Controlled Electrodeposition of Zinc Oxide : Bespoke ZnO Nanostructure Arrays and their Role in Photovoltaics / Miriam Maria Schwarz. Betreuer: Veit Wagner. Gutachter: Veit Wagner ; Dietmar Knipp ; Ulrich Kortz ; Klaus Schmidt." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2015. http://d-nb.info/1087317355/34.
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Wass, Mingus. "Residential segregation of poverty : A longitudinal study of socio-economic segregation in Stockholm County 1991-2016." Thesis, Stockholms universitet, Kulturgeografiska institutionen, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-194198.
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Segregation refers to the uneven spatial distribution of social groups over space. Segregation can be perceived as the spatial representation of social, cultural, and economic exclusion. There is no accepted standard way segregation is measured; instead, studies have used a wide range of methods, measurements, and indices to estimate levels of segregation. Existing studies are seldomly longitudinal in character, mostly because of lack of data, and have only been conducted until 2010 for Stockholm. The aim of this thesis is to investigate trends of residential poverty segregation in Stockholm County for the period 1991-2016. This study has utilized the isolation index, the dissimilarity index, percentile plots and location quotients on data aggregated to both administrative units and individualized neighborhoods on multiple scales to assess how these common techniques influence results. Results show that segregation patterns vary depending on technique, but most results indicate increasing levels of segregation of individuals at risk of poverty for the period 1991-2011, in line with previous research. On the other hand, the results indicate stagnating or decreasing levels of poverty segregation in recent years. Poverty segregation varies substantially by scale level, and therefore this thesis recommends multiscalar methods in segregation studies.
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Thayalakumar, Sinnathurai. "Smart distributed processing technologies for hedge fund management." Thesis, University of Hertfordshire, 2017. http://hdl.handle.net/2299/19622.
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Distributed processing cluster design using commodity hardware and software has proven to be a technological breakthrough in the field of parallel and distributed computing. The research presented herein is the original investigation on distributed processing using hybrid processing clusters to improve the calculation efficiency of the compute-intensive applications. This has opened a new frontier in affordable supercomputing that can be utilised by businesses and industries at various levels. Distributed processing that uses commodity computer clusters has become extremely popular over recent years, particularly among university research groups and research organisations. The research work discussed herein addresses a bespoke-oriented design and implementation of highly specific and different types of distributed processing clusters with applied load balancing techniques that are well suited for particular business requirements. The research was performed in four phases, which are cohesively interconnected, to find a suitable solution using a new type of distributed processing approaches. The first phase is an implementation of a bespoke-type distributed processing cluster using an existing network of workstations as a calculation cluster based on a loosely coupled distributed process system design that has improved calculation efficiency of certain legacy applications. This approach has demonstrated how to design an innovative, cost-effective, and efficient way to utilise a workstation cluster for distributed processing. The second phase is to improve the calculation efficiency of the distributed processing system; a new type of load balancing system is designed to incorporate multiple processing devices. The load balancing system incorporates hardware, software and application related parameters to assigned calculation tasks to each processing devices accordingly. Three types of load balancing methods are tested, static, dynamic and hybrid, which each of them has their own advantages, and all three of them have further improved the calculation efficiency of the distributed processing system. The third phase is to facilitate the company to improve the batch processing application calculation time, and two separate dedicated calculation clusters are built using small form factor (SFF) computers and PCs as separate peer-to-peer (P2P) network based calculation clusters. Multiple batch processing applications were tested on theses clusters, and the results have shown consistent calculation time improvement across all the applications tested. In addition, dedicated clusters are built using SFF computers with reduced power consumption, small cluster size, and comparatively low cost to suit particular business needs. The fourth phase incorporates all the processing devices available in the company as a hybrid calculation cluster utilises various type of servers, workstations, and SFF computers to form a high-throughput distributed processing system that consolidates multiple calculations clusters. These clusters can be utilised as multiple mutually exclusive multiple clusters or combined as a single cluster depending on the applications used. The test results show considerable calculation time improvements by using consolidated calculation cluster in conjunction with rule-based load balancing techniques. The main design concept of the system is based on the original design that uses first principle methods and utilises existing LAN and separate P2P network infrastructures, hardware, and software. Tests and investigations conducted show promising results where the company's legacy applications can be modified and implemented with different types of distributed processing clusters to achieve calculation and processing efficiency for various applications within the company. The test results have confirmed the expected calculation time improvements in controlled environments and show that it is feasible to design and develop a bespoke-type dedicated distributed processing cluster using existing hardware, software, and low-cost SFF computers. Furthermore, a combination of bespoke distributed processing system with appropriate load balancing algorithms has shown considerable calculation time improvements for various legacy and bespoke applications. Hence, the bespoke design is better suited to provide a solution for the calculation of time improvements for critical problems currently faced by the sponsoring company.
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Nguyen, Thi Thanh Loan. "The creation of Uni-REPM A universal model for assessing requirements engineering process maturity." Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-4009.
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Context. The empirical study of Somerville in 2005 has shown that potential business benefits could be achieved by assessing and improving the Requirement Engineering (RE) process. However, currently there has not been an adequate instrument for practitioners to perform this work. Most known process assessment models such as CMMI and ISO do not pay intensive attention on RE whereas tailored models such as GPG and REPM do not cover the mentioned area extensively. Objectives. This thesis presents a conceptual research of RE process assessment in which the researcher aims to develop a practical model for evaluating the maturity of RE processes in industrial settings. Methods. A major part of this study consists of a systematic review and a literature review to explore all RE ―good practices‖ as a profound basis for the new model. Together with identifying potential activities, the two reviews also highly regarded the feasibility of certain practices and their context to assure the validity of the model. Conclusions. Based on the results of the reviews, Uni-REPM is formulated and introduced. The objective of Uni-REPM is twofold. Firstly, it is expected to be applicable for assessing the maturity of RE processes in various scenarios where an organization would use different development approaches. Secondly, it instructs practitioners with what to perform in RE processes and what they would benefit from such activities. As an assessment instrument, Uni-REPM serves a simple and low cost solution for practitioners to identify the status of their RE process. As a guidance tool, Uni-REPM is believed to lessen the gap between theoretical and practical worlds by transferring the available RE technologies from research to real work.
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Telford, Richard. "The Physical Chemistry of pMDI Formulations Derived from Hydrofluoroalkane Propellants. A Study of the Physical Behaviour of Poorly Soluble Active Pharmaceutical Ingredients; Bespoke Analytical Method Development Leading to Novel Formulation Approaches for Product Development." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/10098.
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Active Pharmaceutical Ingredients (APIs) are frequently prepared for delivery to the lung for local topical treatment of diseases such as Chronic Obstructive Pulmonary Disease (COPD) and asthma, or for systemic delivery. One of the most commonly used devices for this purpose is the pressurised metered dose inhaler (pMDI) whereby drugs are formulated in a volatile propellant held under pressure. The compound is aerosolised to a respirably sized dose on actuation, subsequently breathed in by the user. The use of hydrofluoroalkanes (HFAs) in pMDIs since the Montreal Protocol initiated a move away from chlorofluorocarbon (CFC) based devices has resulted in better performing products, with increased lung deposition and a concomitant reduction in oropharyngeal deposition. The physical properties of HFA propellants are however poorly understood and their capacity for solubilising inhaled pharmaceutical products (IPPs) and excipients used historically in CFCs differ significantly. There is therefore a drive to establish methodologies to study these systems in-situ and post actuation to adequately direct formulation strategies for the production of stable and efficacious suspension and solution based products. Characterisation methods have been applied to pMDI dosage systems to gain insight into solubility in HFAs and to determine forms of solid deposits after actuation. A novel quantitative nuclear magnetic resonance method to investigate the physical chemistry of IPPs in these preparations has formed the centrepiece to these studies, accessing solubility data in-situ and at pressure for the first time in HFA propellants. Variable temperature NMR has provided thermodynamic data through van’t Hoff approaches. The methods have been developed and validated using budesonide to provide limits of determination as low as 1 μg/mL and extended to 11 IPPs chosen to represent currently prescribed inhaled corticosteroids (ICS), β2-adrenoagonists and antimuscarinic bronchodilators, and have highlighted solubility variations between the classes of compounds with lipophilic ICSs showing the highest, and hydrophilic β2- agonist/antimuscarinics showing the lowest solubilities from the compounds under study. To determine solid forms on deposition, a series of methods are also described using modified impaction methods in combination with analytical approaches including spectroscopy (μ-Raman), X-ray diffraction, SEM, chromatography and thermal analysis. Their application has ascertained (i) physical form/morphology data on commercial pMDI formulations of the ICS beclomethasone dipropionate (QVAR®/Sanasthmax®, Chiesi) and (ii) distribution assessment in-vitro of ICS/β2-agonist compounds from combination pMDIs confirming co-deposition (Seretide®/Symbicort®, GlaxoSmithKline/AstraZeneca). In combination, these methods provide a platform for development of new formulations based on HFA propellants. The methods have been applied to a number of ‘real’ systems incorporating derivatised cyclodextrins and the co-solvent ethanol, and provide a basis for a comprehensive study of solubilisation of the ICS budesonide in HFA134a using two approaches: mixed solvents and complexation. These new systems provide a novel approach to deliver to the lung, with reduced aerodynamic particle size distribution (APSD) potentially accessing areas suitable for delivery to peripheral areas of the lung (ICS) or to promote systemic delivery.
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Evans, Hayley Ruth. "Synthesis of bespoke matrices to investigate a novel anti-tumour molecular target using affinity chromatography : the design, synthesis and evaluation of biotinylated biarylheterocycles used as novel affinity probes in the identification of anti-tumour molecular targets." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4420.
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Three novel, synthetic biarylheterocycles bearing imidazole terminal groups had previously been discovered with high cytotoxicity (IC₅₀ 16-640 nM) against a number of human tumour cell lines. Notably, this biological activity was independent of duplex DNA binding affinity. The compounds were tested in the NCI 60-cell line panel and COMPARE analysis suggests they have a novel mechanism of action, targeting the product of a 'gene-like sequence' of unidentified function. The identity of likely protein targets was explored using a chemical proteomic strategy. Bespoke affinity matrices for chromatography were prepared in which test compounds were attached to a solid support through a biotin tag. A synthetic route to hit compounds containing a biotin moiety in place of one of the imidazole sidechains was developed. Chemosensitivity studies confirmed that the biotinylated compounds retained their activity showing IC₅₀ = 6.25 μM in a susceptible cell line, compared with > 100 μM for an insensitive cell line. The biotinylated ligands were complexed to a streptavidin-activated affinity column and exposed to cell lysates from the susceptible cell lines. Bound proteins were eluted from the column and separated using SDS-PAGE. Proteins were characterised by MALDI MS and MS/MS and identified using Mascot database searches. Heterogeneous nuclear ribonuclear protein A2/B1 was found to selectively bind to the affinity probes.
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Bateson, Hannah. "Detection and enrichment of cytochrome P450s using bespoke affinity chromatography and proteomic techniques : development of chemical immobilisation and novel affinity chromatography methods, with subsequent proteomic analysis, for the characterisation of cytochrome P450s important in cancer research." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/5712.
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Introduction: Cellular membrane proteins, such as the cytochrome P450 enzyme superfamily (P450), have important roles in the physiology of the cell. P450s are important in metabolising endogenous molecules, as well as metabolising xenobiotic substances for detoxification and excretion. P450s are also implicated in cancer as they can act to 'negatively' de-activate or 'positively' activate cancer therapeutics. Identifying specific P450s that are highly up-regulated at the tumour site could be used to predict drug response and formulate targeted cancer therapy to help diminish systemic side-effects. Methods: Previous enrichment strategies have been unable to isolate the full complement of the P450 superfamily. To develop enrichment procedures for the P450s, a proteomic strategy was developed so that compounds could be screened for their effectiveness as general P450 probes. A standardised work-flow was created, encompassing affinity chromatography, protein concentration/desalting, followed by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and high performance liquid chromatography-mass spectrometry (HPLC-MS). A ketoconazole analogue and a 2-EN analogue, with known P450 inhibition, were immobilised on a solid support for comparison to immobilised histamine. Co-factor removal, competitive elution and DTT cleavage of disulfide bonds of probes were utilised to elute bound proteins. Results/Discussion: Inhibitor-beads bound a large range of proteins, including P450's, of which some were eluted by co-factor removal, some by competitive elution. Specificity of binding was improved by optimising buffer conditions and solid supports, however non-specific binding was not totally eradicated. All human P450s from spiked samples and 18 P450s from more complex mouse liver samples were recovered using one or more ligands.
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Evans, Hayley R. "Synthesis of bespoke matrices to investigate a novel anti-tumour molecular target using affinity chromatography. The design, synthesis and evaluation of biotinylated biarylheterocycles used as novel affinity probes in the identification of anti-tumour molecular targets." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/4420.
Full textAbstract:
Three novel, synthetic biarylheterocycles bearing imidazole terminal groups had previously been discovered with high cytotoxicity (IC50 16¿640 nM) against a number of human tumour cell lines. Notably, this biological activity was independent of duplex DNA binding affinity. The compounds were tested in the NCI 60-cell line panel and COMPARE analysis suggests they have a novel mechanism of action, targeting the product of a ¿gene-like sequence¿ of unidentified function.
The identity of likely protein targets was explored using a chemical proteomic strategy. Bespoke affinity matrices for chromatography were prepared in which test compounds were attached to a solid support through a biotin tag. A synthetic route to hit compounds containing a biotin moiety in place of one of the imidazole sidechains was developed. Chemosensitivity studies confirmed that the biotinylated compounds retained their activity showing IC50 = 6.25 ¿M in a susceptible cell line, compared with > 100 ¿M for an insensitive cell line.
The biotinylated ligands were complexed to a streptavidin-activated affinity column and exposed to cell lysates from the susceptible cell lines. Bound proteins were eluted from the column and separated using SDS-PAGE. Proteins were characterised by MALDI MS and MS/MS and identified using Mascot database searches. Heterogeneous nuclear ribonuclear protein A2/B1 was found to selectively bind to the affinity probes.Yorkshire Cancer Research, BMSS, School of Life Sciences and the Frank Hudson Memorial Fund
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Watson, Naomi Anna. ""Here to stay ... so ... deal with it" : experiences and perceptions of Black British African Caribbean people about nursing careers." Thesis, De Montfort University, 2014. http://hdl.handle.net/2086/10523.
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There is a noticeable absence of studies reflecting the personal views and experiences of black British African Caribbean (BBAC) people as students and clinical participants in UK nursing careers. Previous research about their nursing career choices has always been reported as part of other mixed BME cohorts and migrant groups. Indications in the literature suggest that they were being actively discouraged by their families from choosing nursing as a career, because of their parents’ and grandparents’ negative experiences as migrant workers in the NHS, leading to very low or non-participation in the profession. This study set out to address this gap by giving them a distinct voice, independent of other cohorts. It explored the factors which influence their decision and their experiences, throughout a variety of life stages, from school through to university and into clinical practice. This was to identify whether the findings from earlier research are still relevant from their perspectives rather than that of their parents. Participants and schools in the study were recruited by purposive sampling, and data was collected in three phases, a pilot study phase, a survey phase and an interview phase. A quantitative and qualitative interpretive approach were adopted underpinned by a mixed methods design. Descriptive statistical analysis of the survey and qualitative content analysis (QCA) of the interview transcripts were utilised to enable interrogation of the data. Findings are discussed within the context of available empirical evidence, related policy perspectives and theoretical underpinnings. Four main themes emerged from the study, as specific influencing factors on their experiences. These are: careers advice and choice for nursing, support, discrimination/racism and personal resilience. The findings reveal that BBAC people receive little or no careers advice about nursing at any of their life stages. Consequently, they make uninformed decisions about modern nursing careers, leaving a gap in their knowledge. However, they are not discouraged from choosing nursing as a career, by their families. When they choose a nursing career, they are fully supported and encouraged by their parents and families, in order to survive as students and clinical practitioners. However, institutional support as students and practitioners is weak and very poor. Despite this, they do not intend to actively discourage their own children from making nursing a career choice. Racism, discrimination and racialisation remain core factors influencing their social, educational and other lived experiences, despite numerous equality legislation and implementation. These have a continuous negative impact on them as visible minority students and practitioners in the NHS. They respond to these negative experiences by developing personal resilience aided by strong social and cultural support provided by their families and community. These findings make a unique contribution to the knowledge base by giving BBAC participants their own distinct voice. This was achieved through listening to them at varied points in their life stages, from school through to university and as eventual professionals in nursing. This is important new knowledge, which has ensured a clear recognition of their personal perspectives, in their own voices. These insightful new observations are necessary to build a specific knowledge base about them and are very positive for future participation of BBAC people in nursing careers and the NHS. An adapted model for inclusive participation is proposed, based on the findings of the research.
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Bluteau, Joshua Max. "Authenticity, performance and the construction of self : a journey through the terrestrial and digital landscapes of men's tailored dress." Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/16576.
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This thesis explores high-end and bespoke menswear, tailoring and fashion, asking the question - why do some men choose to spend large sums of money to have clothes made for them? Using tailors and high-end menswear as a lens, this thesis unpacks how men construct their notion of self in the digital and terrestrial worlds through the clothes that they wear and the identities they perform. Based on twelve months' terrestrial fieldwork in London and twenty-four months' concurrent digital fieldwork with Instagram, this thesis examines notions of dress, performance and the individual across a multi-dimensional fieldsite set within a blended digital and terrestrial landscape. The fieldwork comprised visiting and interviewing tailors, and observing inside their workshops and at their fashion shows. In addition, the analyst-as-client built relationships with tailors, and constructed a digital self within Instagram through the publication of self-portraits and images of clothing. This thesis is presented in four chapters, flanked by an Introduction and Conclusion. These chapters move from an exploration of terrestrial research in the first two, to an analysis of digital research in the latter two. Five major motifs emerge in this thesis: the importance of the anthropology of clothing and adornment within western society; the nature of the individual in a digitised world; the difficulty in conducting western-centric fieldwork without an element of digital analysis; a methodological restructuring of digital anthropology; and the idea that a digital self can acquire agency. This thesis employs a pioneering blended methodology which brings together the fields of digital anthropology, visual anthropology and material culture to question how selves are constructed in a rapidly changing and increasingly digitised modernity. In conclusion, the thesis argues that individuals construct multiple digital selves and a sense of identity (around the notion of 'authentic individualism') that is illusory.
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Hulsker, Johannes Lucas Maria. "Petrus Montanus' "Spreeckonst", 1635, nader besproken : een bijdrage tot de geschiedenis van de Nederlandse taalkunde /." Renkum : [J.L.M. Hulsker], 1991. http://catalogue.bnf.fr/ark:/12148/cb35493848j.
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Lin, Chung-Yao, and 林崇曜. "Pricing Bespoke Tranche using Base Expected Loss." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/59580361903044476786.
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碩士國立臺灣大學
財務金融學研究所
97
The compound correlations can be inferred from markets quotes with a standard model; however, there exists the behavior of compound correlation smile. The concept of base correlation which makes evaluation of bespoke tranche possible was introduced by the market, but interpolating base correlation for standard tranches directly will generate unreasonable fair spread for bespoke tranches. This paper discusses the reasons generating unreasonable fair spread for bespoke tranches when performing different interpolations, introduces the idea of base expected loss, and constructs the upper and lower bounds using the properties that the base expected loss must obey; the base correlation implied from base expected loss curve with different interpolation exists the behavior of base correlation smile. Then constructing the base expected loss curve that is monotonic increase and concave down proposed by Parcell & Wood can used to price any bespoke tranches in the absence of arbitrage.
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Arroyo, Miguel Angel. "Bespoke Security for Resource Constrained Cyber-Physical Systems." Thesis, 2021. https://doi.org/10.7916/d8-cgaj-mz52.
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Cyber-Physical Systems (CPSs) are critical to many aspects of our daily lives. Autonomous cars, life saving medical devices, drones for package delivery, and robots for manufacturing are all prime examples of CPSs. The dual cyber/physical operating nature and highly integrated feedback control loops of CPSs means that they inherit security problems from traditional computing systems (e.g., software vulnerabilities, hardware side-channels) and physical systems (e.g., theft, tampering), while additionally introducing challenges of their own. The challenges to achieving security for CPSs stem not only from the interaction of the cyber and physical domains, but from the additional pressures of resource constraints imposed due to cost, limited energy budgets, and real-time nature of workloads. Due to the tight resource constraints of CPSs, there is often little headroom to devote for security. Thus, there is a need for low overhead deployable solutions to harden resource constrained CPSs. This dissertation shows that security can be effectively integrated into resource constrained cyber-physical system devices by leveraging fundamental physical properties, & tailoring and extending age-old abstractions in computing.
To provide context on the state of security for CPSs, this document begins with the development of a unifying framework that can be used to identify threats and opportunities for enforcing security policies while providing a systematic survey of the field. This dissertation characterizes the properties of CPSs and typical components (e.g., sensors, actuators, computing devices) in addition to the software commonly used. We discuss available security primitives and their limitations for both hardware and software. In particular, we focus on software security threats targeting memory safety. The rest of the thesis focuses on the design and implementation of novel, deployable approaches to combat memory safety on resource constrained devices used by CPSs (e.g., 32-bit processors and microcontrollers). We first discuss how cyber-physical system properties such as inertia and feedback can be used to harden software efficiently with minimal modification to both hardware and software. We develop the framework You Only Live Once (YOLO) that proactively resets a device and restores it from a secure verified snapshot. YOLO relies on inertia, to tolerate periods of resets, and on feedback to rebuild state when recovering from a snapshot. YOLO is built upon a theoretical model that is used to determine safe operating parameters to aid a system designer in deployment. We evaluate YOLO in simulation and two real-world CPSs, an engine and drone.
Second, we explore how rethinking of core computing concepts can lead to new fundamental abstractions that can efficiently hide performance overheads usually associated with hardening software against memory safety issues. To this end, we present two techniques: (i) The Phantom Address Space (PAS) is a new architectural concept that can be used to improve N-version systems by (almost) eliminating the overheads associated with handling replicated execution. Specifically, PAS can be used to provide an efficient implementation of a diversification concept known as execution path randomization aimed at thwarting code-reuse attacks. The goal of execution path randomization is to frequently switch between two distinct program variants forcing the attacker to gamble on which code to reuse. (ii) Cache Line Formats (Califorms) introduces a novel method to efficiently store memory in caches. Califorms makes the novel insight that dead spaces in program data due to its memory layout can be used to efficiently implement the concept of memory blacklisting, which prohibits a program from accessing certain memory regions based on program semantics. Califorms not onlyconsumes less memory than prior approaches, but can provide byte-granular protection while limiting the scope of its hardware changes to caches. While both PAS and Califorms were originally designed to target resource constrained devices, it's worth noting that they are widely applicable and can efficiently scale up to mobile, desktop, and server class processors.
As CPSs continue to proliferate and become integrated in more critical infrastructure, security is an increasing concern. However, security will undoubtedly always play second fiddle to financial concerns that affect business bottom lines. Thus, it is important that there be easily deployable, low-overhead solutions that can scale from the most constrained of devices to more featureful systems for future migration. This dissertation is one step towards the goal of providing inexpensive mechanisms to ensure the security of cyber-physical system software.
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Branco, Rodrigues Hugo Emanuel. "Bespoke E-Commerce - Customização em Massa no Calçado: Estudo de Caso Múltiplos." Master's thesis, 2017. http://hdl.handle.net/10400.26/18694.
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Verifica-se uma evolução nas estratégias empresariais de forma a satisfazer as expectativas específicas e individuais dos consumidores, sendo, a heterogeneidade da procura um elemento crítico para o marketing. Dá origem a estratégias de nichos, a ofertas de produtos diferenciadas, e exige um grande esforço efetivo por parte dos profissionais do marketing.
Mass customization é descrita como um modelo que procura oferecer produtos e serviços customizados, ou seja, adaptados às necessidades e preferências dos consumidores, mas produzidos com a mesma eficiência que os produtos padronizados de grande escala. O principal objetivo desta estratégia é habilitar as empresas a reagir rapidamente às mudanças constantes das preferências dos consumidores, resolvendo a heterogeneidade da procura de forma eficiente.
A procura pelo exclusivo e personalizado, evidencia a autenticidade que os consumidores atuais desejam preservar. As pessoas querem sentir-se diferenciadas, únicas e exclusivas, numa era onde tudo é fabricado em série e em larga escala. Este paradigma abriu portas para outros tipos de negócios de artigos personalizados, em diversas áreas.
Uma empresa que opte por adequar a sua oferta ou parte dela à customização, deve primeiro reconhecer a necessidade de ter um processo de fabricação flexível, a possibilidade de reconfigurar os seus produtos ou serviços de acordo com as preferências individuais dos seus consumidores, criar uma plataforma de design envolvente e ter uma gestão eficiente do canal de suprimentos e do seu portfolio de produtos.
Esta tese, com base em estudos de caso múltiplos, pretende analisar os processos técnicos nas empresas alvo, avaliar como estas empresas do setor do calçado utilizam a customização em massa através da web, na sua estratégia empresarial, a sua operacionalização, extensão, etapas e consequências.
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WANG, WEI-KANG, and 王韋剛. "A Study of the Management of Instagram Social Media and Culture Consumption on Bespoke Suit." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/2yfgf7.
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碩士輔仁大學
織品服裝學系碩士班
107
Instagram has been released at 2010, nowadays it dramatically influences the customers and the craftsman of bespoke suit in Taiwan. The effect to the customers are that they may accumulate their cultural capital, cultivate oneself habitus of making choices of bespoke suit, compete with others in the field, and feedback on Instagram after wording one’s personal bespoke suit. To the manufactures, Instagram not only play the role as a marketing tool, but also a platform to educate customers. However, What have customers learned so that they earn more cultural capital than the others? How they cultivate their habitus in the field of bespoke suit? What kind of mindset they hold when engaging in cultural consumption? What marketing strategies the craftsman use to express their taste to the customers, and does it works out and attracts customers to do consumption? Therefore, the main purpose of this study is to investigate the phenomena, which is the difference between the customers after doing cultural consumption, and what role Instagram is playing to customers in bespoke suit field. Beside, the study also investigate how the craftsmen using the 5A marketing strategies to influence the customers. This study adopted in-depth interview, and the subjects are 12 customers of bespoke suit and 3 tailor houses. After analyzing the interview, the study shows that the cultural consumption theory of Pierre Bourdieu also adapt the current society, and even due to the emerge of Instagram, customers may even quicker to obtain all kinds of capital, and transfer than to cultural consumption experiences. The study also shows that the marketing strategies on Instagram truly stimulate the users of it, but it has less effectiveness to profoundly influence the customers. Hope this study could give a new point of view to the industry.
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Uddin, Amad, M. Khurshid Khan, and S. Noor. "Design & implementation of a bespoke MRPII system for a small and medium enterprise (SME) manufacturing company." 2011. http://hdl.handle.net/10454/9513.
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NoDue to significant challenges and increase in competition within the global environment, manufacturing companies need to focus on Manufacturing Planning and Control (MPC) systems in order to gain a competitive edge. This research paper describes a contribution towards the design and implementation of a bespoke MRP II system for a SME company dealing in tool reclamation. The paper covers the investigation of currently available MRP II systems and also investigates the present MPC system of the concerned SME company. On the basis of these investigations, a new/bespoke design has been proposed and developed for an MRP II system that is tailor-made for the aforementioned company. The newly designed MRP II system has been developed (using MS Access and Visual Basic for Application i.e. VBA) as a database planning tool of MPC system and contains the critical modules Demand Management (DM), Rough Cut Capacity Planning (RCCP), Master Production Scheduling (MPS), Material Requirements Planning (MRP), and Capacity Requirements Planning (CRP). The bespoke MRP II system has been tested within the real manufacturing environment existing in the SME company with positive results. The key outcome of the research has shown that even small SME’s can design and implement their own MRPII system, which is particular and relevant to their own special manufacturing environment, using a minimal of time, software and financial resources.
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Arafat, B., M. Wojsz, A. Isreb, R. T. Forbes, Mohammad Isreb, W. Ahmed, T. Arafat, and M. A. Alhnan. "Tablet fragmentation without a disintegrant: A novel design approach for accelerating disintegration and drug release from 3D printed cellulosic tablets." 2018. http://hdl.handle.net/10454/17495.
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YesFused deposition modelling (FDM) 3D printing has shown the most immediate potential for on-demand dose personalisation to suit particular patient's needs. However, FDM 3D printing often involves employing a relatively large molecular weight thermoplastic polymer and results in extended release pattern. It is therefore essential to fast-track drug release from the 3D printed objects. This work employed an innovative design approach of tablets with unique built-in gaps (Gaplets) with the aim of accelerating drug release. The novel tablet design is composed of 9 repeating units (blocks) connected with 3 bridges to allow the generation of 8 gaps. The impact of size of the block, the number of bridges and the spacing between different blocks was investigated. Increasing the inter-block space reduced mechanical resistance of the unit, however, tablets continued to meet pharmacopeial standards for friability. Upon introduction into gastric medium, the 1 mm spaces gaplet broke into mini-structures within 4 min and met the USP criteria of immediate release products (86.7% drug release at 30 min). Real-time ultraviolet (UV) imaging indicated that the cellulosic matrix expanded due to swelling of hydroxypropyl cellulose (HPC) upon introduction to the dissolution medium. This was followed by a steady erosion of the polymeric matrix at a rate of 8 μm/min. The design approach was more efficient than a comparison conventional formulation approach of adding disintegrants to accelerate tablet disintegration and drug release. This work provides a novel example where computer-aided design was instrumental at modifying the performance of solid dosage forms. Such an example may serve as the foundation for a new generation of dosage forms with complicated geometric structures to achieve functionality that is usually achieved by a sophisticated formulation approach.
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Oltean-Dumbrava, Crina, Gregory R. Watts, and Abdul H. S. Miah. "“Top-Down-Bottom-Up” Methodology as a Common Approach to Defining Bespoke Sets of Sustainability Assessment Criteria for the Built Environment." 2013. http://hdl.handle.net/10454/7745.
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YesThe top-down-bottom-up (TDBU) methodology for defining bespoke sets of sustainability criteria for specific civil engineering project types is introduced and discussed. The need to define sustainability criteria for specific civil engineering project types occurs mainly in one or both of the following cases: (1) when a more comprehensive and indicative assessment of the sustainability of the project type in question is required; and/or (2) there is no readily available bespoke sustainability assessment tool, or set of criteria, for assessing the sustainability of the project type. The construction of roads, buildings, airports, tunnels, dams, flood banks, bridges, water supply, and sewage systems and their supporting systems are considered to be unique civil engineering/infrastructure project types. The normative definition of sustainable civil engineering/infrastructure projects and the framework for assessing its sustainability is defined and provided by the authors. An example of the TDBU methodology being applied to define sustainability criteria for transport noise reducing devices is presented and discussed. The end result of applying the methodology is a systematically researched and industry validated set of criteria that denotes assessing the sustainability of the civil engineering/infrastructure project type. The paper concludes that the top-down-bottom-up will support stakeholders and managers involved in assessing sustainability to consider all major research methods to define general and unique sustainability criteria to assess and so maximize sustainability.
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Pereira, B. C., Abdullah Isreb, Mohammad Isreb, R. T. Forbes, E. F. Oga, and M. A. Alhnan. "Additive Manufacturing of a Point-of-Care “Polypill:” Fabrication of Concept Capsules of Complex Geometry with Bespoke Release against Cardiovascular Disease." 2020. http://hdl.handle.net/10454/18004.
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YesPolypharmacy is often needed for the management of cardiovascular diseases and is associated with poor adherence to treatment. Hence, highly flexible and adaptable systems are in high demand to accommodate complex therapeutic regimens. A novel design approach is employed to fabricate highly modular 3D printed “polypill” capsules with bespoke release patterns for multiple drugs. Complex structures are devised using combined fused deposition modeling 3D printing aligned with hot-filling syringes. Two unibody highly modular capsule skeletons with four separate compartments are devised: i) concentric format: two external compartments for early release while two inner compartments for delayed release, or ii) parallel format: where nondissolving capsule shells with free-pass corridors and dissolution rate-limiting pores are used to achieve immediate and extended drug releases, respectively. Controlling drug release is achieved through digital manipulation of shell thickness in the concentric format or the size of the rate limiting pores in the parallel format. Target drug release profiles are achieved with variable orders and configurations, hence confirming the modular nature with capacity to accommodate therapeutics of different properties. Projection of the pharmacokinetic profile of this digital system capsules reveal how the developed approach can be applied in dose individualization and achieving multiple desired pharmacokinetic profiles.
The full-text of this article will be released for public view at the end of the publisher embargo on 9 Jun 2021.
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Little, Charlotte. "Timely/timeless : the new bespoke : a thesis presented in partial fulfilment of the requirements for the degree of Master of Design at Massey University, Wellington, New Zealand." 2009. http://hdl.handle.net/10179/1348.
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Mass-production and consumption is causing mountains of waste, overwhelming our fragile world. Since the fast fashion industry is one of the major contributors of waste, it is vital we change the way we produce, consume and market clothing in order to address concerns such as global warming. We need to consider how we can make clothing within a closed cycle to minimise waste. The garments should either be biodegradable and become nutrients for the earth, or be able to go back into the technological cycle, i.e. to be stripped of components and reused, or else up-cycled with zero waste; a cradle-to-cradle life cycle (McDonough & Braungart, 2002). This project explores how a more sustainable relationship can be created between the designer, consumer and their community, in an attempt to slow the fashion industry down. Drawing upon sustainability theories I apply a new system of design, production and consumption that fosters relationships and active participation in the garment manufacturing process, as well as making clothing that is tailored for an individual’s lifestyle. In this project I have created bespoke clothing items for and with three people. The clothes are conceived as treasures that my clients can keep forever. Instead of simply being fashionable and of the time, the New Bespoke clothing is both timely and timeless. Through a series of consultations I develop an understanding of my clients personality and lifestyle, and through photographic explorations I develop a silhouette from their current wardrobe from which to design the garments. The transparency of this production system is aimed to educate my clients about environmental issues in the fashion industry, and to change their perception of the value of clothing.