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Dissertations / Theses on the topic 'Beta agonists'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Elliott, Christopher T. "Detection, pharmacokinetics and molecular mimicry of beta agonists." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247342.

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2

Sweet, Andrew. "#beta#-adrenergic agonists and lean deposition in animals." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292616.

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3

Koch, Sarah. "Pharmacogenetics of inhaled beta-2-agonists and athletic performance." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/37901.

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The A46G single nucleotide polymorphism (SNP) and the C79G SNP of the adrenergic β2-receptor gene (ADRB2) are associated with the regulation of cardiorespiratory responses, to the inhalation of salbutamol, such as bronchodilation, heart rate and ventilation. PURPOSE: To determine (1) the effect of susceptibility to exercise-induced bronchoconstriction (EIB) and (2) the effect of genetic variation at the ADRB2 A46G and the C79G SNPs on athletic performance after the inhalation of salbutamol. METHODS: Genetic variation for the A46G SNP (AA: 4; AG: 15; GG: 21; unidentified: 2) and the C79G SNP

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4

Thompson-Coon, J. "Clinical studies on interactions between #beta#-agonists and glucocorticoids." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285776.

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5

Gill, Hardyal S. "Soft [beta]-adrenoceptor agonists for topical use in psoriasis." Thesis, Aston University, 1994. http://publications.aston.ac.uk/11053/.

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Psoriasis is characterised by epidermal proliferation and inflammation resulting in the appearance of elevated erythematous plaques. The ratio of c~AMP/c~GMP is decreased in psoriatic skin and when the epidermal cell surface receptors are stimulated by β-adrenergic agonists, intracellular ATP is transformed into c-AMP, thus restoring the c~AMP/c~GMP levels. This thesis describes a series of β-adrenoceptor agonists for topical delivery based upon the soft-drug approach. Soft drugs are defined as biologically active, therapeutically useful chemical compounds (drugs) characterised by a predictabl

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6

Twentyman, Orion Peter. "Mechanisms of allergen-induced late phase asthmatic responses and increased bronchial responsiveness." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296053.

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7

Van, Patrick P. T. "Comparison of nebulised vs MDI-spacer delivered beta-2 agonist therapy in patients with asthma in the community." Thesis, The University of Sydney, 2001. https://hdl.handle.net/2123/27750.

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Objective: The aim of this study was to determine whether asthma symptoms and beta-2 agonist usage were any different between community patients using a nebuliser or a metereddose inhaler with a spacer (MDI—spacer) to deliver beta-2 agonist for the relief of symptoms. Design and setting: A randomised intervention versus control group study in a community pharmacy. Participants: 48 patients with asthma over 2 years of age; 34 completed the study. Intervention: Subjects with a repeat prescription for salbutamol nebules were randomised to switch to MDI—spacer with patient counselling and

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8

Clausen, Lisa. "Effects of beta-2 adrenergic receptor agonists in DOK7 congenital myasthenic syndrome." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:9360c51b-8497-47ca-bd16-e917a3614a25.

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Congenital myasthenic syndromes (CMS) are a rare group of heterogeneous disorders, characterised by compromised neuromuscular transmission and symptoms of fatiguable muscle weakness. CMS is caused by mutations in genes that affect the structure and function of the neuromuscular junction (NMJ). In about 20% of CMS cases, patients have mutations in the gene DOK7; the protein product, DOK7, is crucial for maintaining the dense aggregation of acetylcholine receptor (AChR) clusters at the NMJ. DOK7-CMS patients do not respond to treatment with acetylcholinesterase inhibitors which are the first lin

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9

Vathenen, Arumugam Santhire. "The effect of beta agonists and corticosteroids on bronchial reactivity in asthma." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278555.

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10

Salie, Ruduwaan. "The mechanism of pharmacological preconditioning of rat myocardium with beta-adrenergic agonists." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6630.

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Thesis (PhD)--University of Stellenbosch, 2011.<br>ENGLISH ABSTRACT: The Mechanism of -adrenergic preconditioning ( -PC) Ischaemic preconditioning (IPC), a potent endogenous protective intervention against myocardial ischaemia, is induced by exposure of the heart to repetitive short episodes of ischaemia and reperfusion. The protective effects of this phenomenon have been demonstrated to be mediated by release of autocoids such as adenosine, opioids and bradykinin. Release of endogenous catecholamines and activation of the beta-adrenergic receptors (b-AR) have also been shown to be invo

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11

Clausen, Lisa K. J. "Effects of beta-2 adrenergic receptor agonists in DOK7 congenital myasthenic syndromes." Thesis, University of Oxford, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.712079.

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12

McGrath, Gareth. "The determination of selected drugs and endogenous molecules by modern electrophoretic, chromatographic and voltammetric techniques." Thesis, University of Ulster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241755.

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13

Brown, Julie. "The effects of #beta#-adrenergic agonists on hind-limb metabolism in growing lambs." Thesis, University of Reading, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293730.

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14

Cates, Christopher Joseph. "Assessing the risks of serious adverse events from regular long-acting beta-agonists for adults and children with asthma." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609397.

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15

Oguma, Tetsuya, Hiroaki Kume, Takayuki Ishikawa та ін. "The Effect of β-adrenargic Agonists on Ca^2+ Sensitivity in Tracheal Smooth Muscle". Research Institute of Environmental Medicine, Nagoya University, 2003. http://hdl.handle.net/2237/7593.

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16

Frese, Daniel A. "Clinical and diagnostic evaluation of finished cattle exposed to beta adrenergic agonists and physical exertion." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/20334.

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Doctor of Philosophy<br>Department of Diagnostic Medicine/Pathobiology<br>Daniel U. Thomson<br>The widespread use of beta adrenergic agonists in beef cattle production has been adopted by the beef industry in recent years to improve weight gain and feed efficiency at the end of the feeding period. During this feeding period, anecdotal reports of increased mortality during the timeframe in which beta agonists were being fed to cattle was also reported, and confirmed in epidemiologic studies. Additionally, adverse animal welfare events at abattoirs in cattle fed beta adrenergic agonists were r

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17

Reed, Anna Katja. "The potential role for PPAR beta/delta agonists in the treatment of pulmonary arterial hypertension." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540630.

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18

Bell, Christopher John. "The regulation of protein kinase B and glycogen synthase kinase 3 by beta adrenergic agonists." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268781.

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19

McCrea, Karen Elaine. "The effect of long-acting #beta#â†2-adrenoreceptor agonists on cAMP accumulation in cultured cells." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262234.

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20

Wardle, Robert L. "Functional antagonism between muscarinic receptor and beta-adrenergic receptor agonists in equine trachealis muscle in vitro /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487858417981441.

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21

Ryberg, Mats. "Chronic treatment with [beta]-adrenoceptor agonists in asthmatics effects on salivary gland function and dental caries development /." Umeå : University of Umeå, 1991. http://catalog.hathitrust.org/api/volumes/oclc/23592154.html.

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22

Rahman, Shazia. "Use of (2S)-pyroglutamic acid for the synthesis of glutamate agonists and antagonists and 1-#beta#-methylcarbapenams." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264581.

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23

Tabrizchi, Reza. "Different modes of vasopressor actions of angiotensin and non-selective or selective beta-adrenoceptor antagonists." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/29439.

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Vasoconstriction can be initiated via the interaction of a number of chemicals with specific "receptive sites" known as the receptors. This thesis examines two distinctly different modes by which drugs initiate a contractile response, namely, (i) the interaction of angiotensin analogues with a heterogeneous population of angiotensin receptors in vascular smooth muscles, and (ii) the conditions whereby B-adrenoceptor antagonists interact with a-adrenoceptor antagonists thereby causing a pressor response. Conscious, unrestrained, instrumented-rats were used for the study. It has been suggested

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24

Hagenmaier, Jacob Andrew. "Investigation into an ongoing dilemma: undefined welfare implications challenging the use of β-adrenergic agonists in beef production". Diss., Kansas State University, 2016. http://hdl.handle.net/2097/35217.

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Doctor of Philosophy<br>Department of Diagnostic Medicine/Pathobiology<br>Daniel U. Thomson<br>Beta-adrenergic agonists (βAA) are administered during the final weeks of the beef production system to improve efficiency and increase meat yield. Welfare concerns linked to the administration of βAA have garnered significant attention in recent years due to anecdotal reports of increased mortality during βAA feeding periods and cattle without obvious disease or injury having difficulty walking at abattoirs being overrepresented in cattle fed βAA. Thomson et al. (2015) reported 2 events where cattle

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25

Apolinar, Sanrda. "BK channel involvement in beta-adrenergic relaxation of murine tracheal smooth muscle a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=32&CISOBOX=1&REC=3.

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26

Brake, Derek William. "Effect of Beta-adrenergic agonists on urea recycling by cattle fed varying levels and forms of nitrogen supplementation." Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/1667.

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27

Sanja, Hromiš. "Procena efikasnosti kombinovane antiinflamatorne terapije u postizanju dobre kontrole astme u zavisnosti od navike pušenja." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=95463&source=NDLTD&language=en.

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Uvod: Pu&scaron;enje predstavlja jedan od najznačajnijih uzroka lo&scaron;e kontrole astme, zbog iritativnog dejstva duvanskog dima na disajne puteve i razvoja rezistencije na inhalatorne kortikosteroide. Stoga je pu&scaron;ače sa astmom često potrebno lečiti kombinovanom antiinflamatornom terapijom, iako je efikasnost ovakvog tretmana jo&scaron; uvek nedovoljno ispitana. Cilj: utvrditi efikasnost kombinovane antiinflamatorne terapije: inhalatorni kortikosteroidi (ICS) u kombinaciji sa dugodelujućim beta2-adrenergičkim agonistima (DDBA) u odnosu na ICS u kombinaciji sa antagonistima leukotrije

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28

Molphy, John. "The impact of acute and chronic administration of short-acting β2-agonists on urinary pharmacokinetics and athletic performance". Thesis, Liverpool John Moores University, 2015. http://researchonline.ljmu.ac.uk/4330/.

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Exercise Induced Bronchoconstriction (EIB) is common amongst elite athletes. Short-acting β2-agonists represent the first-line treatment of EIB, however; limited data currently exists examining the ergogenic and pharmacokinetic impact of chronic short-acting β2-agonist administration. Furthermore, the ergogenic impact of acute and chronic administration of short-acting β2-agonists in asthmatic individuals is unknown. Whilst the short-acting β2-agonist salbutamol is permitted in and out of competition due to a known pharmacokinetic response, no urinary threshold has been established for the use

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29

Wilchesky, Machelle 1965. "Arrhythmia risk associated with the use of bronchodilators in patients with chronic obstructive pulmonary disease : cohort studies and methodological issues." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115713.

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Whereas first line therapy for chronic obstructive pulmonary disease (COPD) usually includes a short-acting bronchodilator, there are suggestions that these agents may increase the risk of cardiac arrhythmias. In this thesis, we first assessed the risks associated with short-acting beta-agonists (SABA), long-acting beta-agonists (LABA), ipratropium bromide (IB), and methyl xanthines (MX) within a cohort of COPD patients using the health databases of Saskatchewan. In order to confirm these findings and to address some methodological issues we then replicated this analysis within a larger cohort

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30

Ogale, Sarika S. "Mortality and cardiovascular outcomes associated with medications used in the treatment of chronic obstructive pulmonary disease /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/7959.

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31

Carvalho, Marcos Fiuza de. "Analysis of phosphodiesterase inhibitors effect type 5 and beta-adrenergic agonists in parameters of mice urodynamic using model of experimental hyperactivity detrusor." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16094.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>Pharmacological treatment of detrusor overactivity (DO) has been classically done with antimuscarinics. Recently new pharmacological agents or association of drugs have been used to treat DO. One of them are the beta3 agonists. Beta 3 agonists increase intracellular cyclic adenosine monophosphate (cAMP) through adenylyl cyclase pathway. cAMP induces detrusor smooth muscle (DSM) relaxation. Phosphodiesterase type 5 inhibitors (PDE-5i) like tadalafil also cause DSM relaxation through nitric oxide/cyclic guanosine monophosphate (NO/cGM

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32

Gulliksson, Magdalena. "Mast cell activation in response to osmotic and immunological stimulation with focus on release of eicosanoid mediators /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-091-6/.

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33

LI, YINGXUE. "DESIGN, SYNTHESIS, AND CHARACTERIZATION OF HELICAL OPIOID GLYCOPEPTIDE AGONISTS: THE STUDY OF THE STRUCTURE-ACTIVITY RELATIONSHIP AND TRANSPORT OF GLYCOPEPTIDES RELATED TO BETA-ENDORPHIN AND DYNORPHIN." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/203033.

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Structure-activity relationships (SAR) of opioid peptide analogues related to endorphin or dynorphin have provided rational and powerful approaches toward the design of peptide therapeutics. A series of glycosylated β-endorphin analogues were designed by modifying the N-terminal “message domain,” the C-terminal “address domain,” and the “linkage domain” between the two, and by altering the intrinsic helix stability of the amphipathic helix that comprises the “address domain.” Further changes were accomplished by altering the charged groups on the side chains of the “address region.” The unglyc

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34

Santos, Antonio Carlos Ramos dos. "Efeitos do período de administração de cloridrato de zilpaterol e do tempo de confinamento no desempenho, características de carcaça e qualidade de carne de bovinos Nelore." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-16042015-110758/.

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O objetivo desta pesquisa foi avaliar os efeitos do período de administração de cloridrato de zilpaterol (CZ) e do tempo de confinamento no desempenho, características de carcaça, rendimento de cortes cárneos comerciais e na qualidade de carne de bovinos Nelore. Foram utilizados 96 bovinos machos não castrados da raça Nelore, com peso vivo inicial de 377 ± 25,1 kg. O delineamento utilizado foi o de blocos completos casualizados em esquema fatorial 4 × 2, sendo quatro períodos de administração com CZ (0, 20, 30 ou 40 dias) e dois tempos de confinamento (90 ou 117 dias). O período de suplementaç

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35

Penny, Daniel James. "Changes in integrated cardiovascular physiology during inotropic stimulation in the early postnatal period." Monash University, Institute of Reproduction and Development, 2004. http://arrow.monash.edu.au/hdl/1959.1/9661.

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36

Wang, Jianpu. "Pathophysiology and treatment of chlorine gas-induced lung injury : an experimental study in pigs /." Linköping : Univ, 2004. http://www.bibl.liu.se/liupubl/disp/disp2004/med877s.pdf.

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37

Carie, Adam E. "Tumor suppressive effects of the Beta-2 adrenergic receptor and the small GTPase RhoB." [Tampa, Fla.] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002330.

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38

Herepath, Michael Leonard. "Agonist-induced sensitivity changes at #beta#-adrenoceptors." Thesis, Cardiff University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328051.

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39

Oliveira, Simone Raymundo de. "Efeito da adição de ractopamina e da imunocastração na carne in natura de suínos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-18112016-151135/.

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A moderna suinocultura vem nos últimos anos avançando no desenvolvimento e no emprego de tecnologias que visam o aumento da performance produtiva e econômica do segmento. As inovações associadas aos métodos de castração e modificadores metabólicos têm sido avaliadas, em particular o uso da imunocastração e dos repartidores de energia (ractopamina). Embora os ganhos zootécnicos e industriais destas tecnologias já estejam bem discutidos, o real impacto do emprego juntas ou isoladas sobre a qualidade tecnológica da carne pelo seu efeito na matriz bioquímica, necessita de estudos mais aprofundados

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40

McCaffrey, Patricia Marion. "Studies of agonist and partial agonist activity at the beta-adrenoceptor in man." Thesis, Queen's University Belfast, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317034.

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41

Nieland, Nick. "Investigations of derivatives of 14#beta#-amino-7,8-dihydromorphinone." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265328.

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42

Parr, Timothy. "Calpain proteinase mRNA and beta-agonist induced muscle growth." Thesis, University of Nottingham, 1991. http://eprints.nottingham.ac.uk/11445/.

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The mechanism by which β-agonists induce skeletal muscle hypertrophy is believed largely to be through a reduction in protein degradation. These growth promoters are also known to effect the activity of the calcium dependent proteinases (calpains) and their specific endogenous inhibitor calpastatin. The changes in activity appear to be toward a decrease in the calpain system's proteolytic potential. In this study attempts were made to determine whether the altered activity of the enzymes and inhibitor were brought about by induced changes in gene expression as reflected by altered levels of sp

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43

Lortie, Michel B. "The rainbow trout muscle beta(2)-adrenoceptor system: Impact of beta(2)-agonist feeding." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6268.

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Previous studies showed that beta2-adrenergic agonists (beta 2-AAs) enhanced muscle growth and reduced lipid deposition in animals of agricultural and economical importance, including teleost fish. The goal of the present study was to provide a mechanistic explanation underlying the reported beta2-AA-induced muscle growth in the rainbow trout (Oncorhynchus mykiss). Using radioligand binding assays and adenylyl cyclase/cAMP assays, this study characterized and demonstrated the presence of functional beta2-adrenoceptors (beta2-ARs) on red and white muscle membranes. Trout fed 40 ppm of two beta2

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44

Schirrmacher, Esther. "18F- und 11C-Markierung des [beta]-2-adrenergen [Beta-2-adrenergen] Agonisten Fenoterol." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=974171999.

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45

Arnold, Ian Robert. "In vivo regulation of cardiac beta-adrenoceptors by a partial agonist." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35645.

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Chronic therapy with the beta1 selective partial agonist xamoterol is not associated with the tolerance seen with agonists of greater intrinsic activity. In order to investigate whether this could be explained by the effect of xamoterol on the in vivo regulation of cardiac beta-adrenoceptors, 2 studies have been performed. 40 right atrial biopsies were obtained from 55 patients prospectively randomised in a double blind fashion to receive either xamoterol or the beta1 selective antagonist atenolol (previously shown to upregulate beta1-adrenoceptors and enhance beta2 mediated responses) for at

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46

Rajab, P. E. "The metabolic, biochemical and cardiovascular effects of treatment with clenbuterol in the rat." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285682.

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47

Moura, Andre Luiz de. "Sensibilidade a agonistas [beta]-adrenergicos em atrio esquerdo isolado de ratos submetidos a estresse." [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314622.

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Orientadores: Regina Celia Spadari-Bratfisch, Dora Maria Grassi-Kassisse<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-02T14:08:15Z (GMT). No. of bitstreams: 1 Moura_AndreLuizde_M.pdf: 4831255 bytes, checksum: 89a79fa25a0a6831c383781d8adbb2ce (MD5) Previous issue date: 2002<br>Resumo: O estresse por choque nas patas promove supersensibilidade ao efeito cronotrópico positivo da isoprenalina em átrios direitos isolados de ratos e ratas sacrificadas em diestro, a qual está associada a aumento da proteína do adrenocept

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48

Gangadharan, Denise Michelle. "Thymic development of CS8[alpha][alpha]⁺ TCR[alpha][beta]⁺ agonist selected IEL." Diss., Connected to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3189998.

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Thesis (Ph. D.)--University of California, San Diego, 2005.<br>Title from first page of PDF file (viewed Marc 6, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 100-116).

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49

Van, der Weyde Marlene P. "The effects of the beta-adrenergic agonist, ritodrine, in the fetal lamb." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30417.

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Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral effects of ritodrine in the fetus, using the chronically instrumented pregnant sheep as an experimental model. Ritodrine was infused continuously into 11 fetal lambs at a rate of 2.6 ug/minute for a period of 8, 12 or 24 hours. Samples were taken simultaneously at predetermined time periods from a

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50

ALKO, DANIEL. "Metabolisme compare du clenbuterol chez le rat et le veau : implications pour l'evaluation toxicologique des beta-agonistes utilises en elevage (doctorat : toxicologie)." Paris 5, 1998. http://www.theses.fr/1998PA05N050.

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