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Relevant bibliographies by topics / Beta-Amino ester

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Journal articles
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Academic literature on the topic 'Beta-Amino ester'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Beta-Amino ester"

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Lakes, Andrew L., Carolyn T. Jordan, Prachi Gupta, David A. Puleo, J. Zach Hilt, and Thomas D. Dziubla. "Reducible disulfide poly(beta-amino ester) hydrogels for antioxidant delivery." Acta Biomaterialia 68 (March 2018): 178–89. http://dx.doi.org/10.1016/j.actbio.2017.12.030.

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Muramatsu, M., K. Kaibuchi, and K. Arai. "A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester." Molecular and Cellular Biology 9, no. 2 (1989): 831–36. http://dx.doi.org/10.1128/mcb.9.2.831.

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We constructed mutant protein kinase C (PKC) cDNAs which expressed PKC activity in vivo in the absence of phorbol ester activation. A hybrid PKC gene, PKAC, was constructed by substituting the coding region for the N-terminal 253 amino acids of PKC alpha with the N-terminal 17 amino acids of the cyclic AMP-dependent protein kinase catalytic subunit (PKA). A truncated PKC gene, delta PKC beta, lacking the coding region for amino acid positions 6 to 159 of PKC beta was also constructed. These mutant kinase genes expressed under the control of the SR alpha promoter activated the c-fos gene enhanc

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Muramatsu, M., K. Kaibuchi, and K. Arai. "A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester." Molecular and Cellular Biology 9, no. 2 (1989): 831–36. http://dx.doi.org/10.1128/mcb.9.2.831-836.1989.

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We constructed mutant protein kinase C (PKC) cDNAs which expressed PKC activity in vivo in the absence of phorbol ester activation. A hybrid PKC gene, PKAC, was constructed by substituting the coding region for the N-terminal 253 amino acids of PKC alpha with the N-terminal 17 amino acids of the cyclic AMP-dependent protein kinase catalytic subunit (PKA). A truncated PKC gene, delta PKC beta, lacking the coding region for amino acid positions 6 to 159 of PKC beta was also constructed. These mutant kinase genes expressed under the control of the SR alpha promoter activated the c-fos gene enhanc

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Lakes, Andrew, David Puleo, J. Hilt, and Thomas Dziubla. "Highly Thiolated Poly (Beta-Amino Ester) Nanoparticles for Acute Redox Applications." Gels 4, no. 4 (2018): 80. http://dx.doi.org/10.3390/gels4040080.

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Disulfides are used extensively in reversible cross-linking because of the ease of reduction into click-reactive thiols. However, the free-radical scavenging properties upon reduction are often under-considered. The free thiols produced upon reduction of this disulfide material mimic the cellular reducing chemistry (glutathione) that serves as a buffer against acute oxidative stress. A nanoparticle formulation producing biologically relevant concentrations of thiols may not only provide ample chemical conjugation sites, but potentially be useful against severe acute oxidative stress exposure,

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Saeedi, Tahani, and Polina Prokopovich. "Poly beta amino ester coated emulsions of NSAIDs for cartilage treatment." Journal of Materials Chemistry B 9, no. 29 (2021): 5837–47. http://dx.doi.org/10.1039/d1tb01024g.

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Delivering drugs directly into cartilage is still the major challenge in the management and treatment of osteoarthritis (OA) resulting from the aneural, avascular and alymphatic nature of an articular cartilage structure.

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Bishop, C. J., B. Abubaker-Sharif, T. Guiriba, S. Y. Tzeng, and J. J. Green. "Gene delivery polymer structure–function relationships elucidated via principal component analysis." Chemical Communications 51, no. 60 (2015): 12134–37. http://dx.doi.org/10.1039/c5cc04417k.

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Hibbs, M. L., S. Jakes, S. A. Stacker, R. W. Wallace, and T. A. Springer. "The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site." Journal of Experimental Medicine 174, no. 5 (1991): 1227–38. http://dx.doi.org/10.1084/jem.174.5.1227.

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We have defined the regions of the cytoplasmic domain of the leukocyte integrin lymphocyte function-associated antigen 1 (LFA-1) that are required for active binding of its extracellular domain to intercellular adhesion molecule 1 (ICAM-1). The NH2-terminal 28 amino acids in the cytoplasmic domain are dispensable, but a segment of 5 amino acids including three contiguous threonines (758-760) and Phe 766 in the COOH-terminal third of the cytoplasmic domain are required for binding to ICAM-1. Mutation and phosphoamino acid analysis show that Ser 756 is the major residue phosphorylated in respons

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Karlsson, Johan, Kelly R. Rhodes, Jordan J. Green, and Stephany Y. Tzeng. "Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities." Expert Opinion on Drug Delivery 17, no. 10 (2020): 1395–410. http://dx.doi.org/10.1080/17425247.2020.1796628.

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Dold, Neil M., Qin Zeng, Xiangbin Zeng та Christopher M. Jewell. "A poly(beta-amino ester) activates macrophages independent of NF-κB signaling". Acta Biomaterialia 68 (березень 2018): 168–77. http://dx.doi.org/10.1016/j.actbio.2017.12.040.

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Perlmutter, Patrick, and Mark Tabone. "A Simple Route to .alpha.-Substituted-.beta.-Amino Ester Precursors of Carbapenem Antibiotics." Journal of Organic Chemistry 60, no. 20 (1995): 6515–22. http://dx.doi.org/10.1021/jo00125a043.

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Dissertations / Theses on the topic "Beta-Amino ester"

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Safranski, David Lee. "Poly(beta-amino esters) for cardiovascular applications." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42825.

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Abdominal aortic aneurysms are a leading cause of death in the U.S. where 14,000 people die from aneurysm rupture and 178,000 are diagnosed each year. A novel alternative treatment for abdominal aortic aneurysms has been proposed, where a biodegradable polymer scaffold is photopolymerized in situ around the exterior of the aneurysm. This scaffold will mechanically constrain the aneurysm from further expansion, and will deliver a drug, doxycycline, to treat the underlying biological cause of the disease. In order for device development, a suitable polymer must be designed with appropriate mecha

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Lakes, Andrew L. "BIOACTIVE POLY(BETA-AMINO ESTER) BIOMATERIALS FOR TREATMENT OF INFECTION AND OXIDATIVE STRESS." UKnowledge, 2016. http://uknowledge.uky.edu/cme_etds/57.

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Polymers have deep roots as drug delivery tools, and are widely used in clinical to private settings. Currently, however, numerous traditional therapies exist which may be improved through use of polymeric biomaterials. Through our work with infectious and oxidative stress disease prevention and treatment, we aimed to develop application driven, enhanced therapies utilizing new classes of polymers synthesized in-house. Applying biodegradable poly(β-amino ester) (PBAE) polymers, covalent-addition of bioactive substrates to these PBAEs avoided certain pitfalls of free-loaded and non-degradable d

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Little, Steven (Steven Ronald). "Poly ([beta]-amino ester)s as pH sensitive biomaterials for microparticulate genetic vaccine delivery." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34159.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.<br>In title on t.p., "beta" appears as lower-case Greek letter.<br>Includes bibliographical references.<br>Genetic vaccination is the administration of nucleic acids to induce cellular expression of antigens, leading to an immune response. Unlike traditional vaccines, this technology has tremendous potential for treating or preventing diseases such as HIV, malaria, and cancer. However, this potential is currently unrealized because of the safety concerns which plague viral vaccine carriers and the inef

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Keim, Terra Ann. "Synthesis, Characterization, and Cyclic Stress Influenced Degradation of a Poly(Ethylene) Glycol Based Poly(Beta-Amino Ester)." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19872.

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Poly(beta-amino esters) are photopolymerizable and biodegradable polymers prepared by the combination of amines with diacrylates. This study aims to fundamentally understand the polymer network formed by poly(ethylene)glycol diacrylate (PEGDA) MW 700 and 3-methoxypropylamine (3MOPA) as well as to characterize the degradation response of this material with and without cyclic loading. The networks were formed by a two-step process; (1) the synthesis of amine-co-peg diacrylate macromers through a step growth reaction, followed by (2) UV initiated chain growth network formation of the diacrylate

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Jordan, Carolyn T. "DESIGN AND ANALYSIS OF CURCUMIN CONJUGATED POLY(BETA-AMINO ESTER) NETWORKS FOR CONTROLLED RELEASE IN OXIDATIVE STRESS ENVIRONMENTS." UKnowledge, 2018. https://uknowledge.uky.edu/cme_etds/84.

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Oxidative stress, the imbalance of free radical generation with antioxidant defenses, leads to cellular inflammation, apoptosis and cell death. This compromised environment results in debilitating diseases, such as oral mucositis (OM), atherosclerosis, and ischemia/reperfusion injury. Antioxidant therapeutics has been a proposed strategy to ameliorate these imbalances and maintain homeostatic environments. However, the success of these approaches, specifically curcumin, has been limited due to characteristics such as hydrophobicity and high reactivity when released as bolus doses to contest to

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Pignon, Antoine. "Réactions multicomposants aux organométalliques : nouveaux développements et application à la préparation d'hétérocycles azotés." Thesis, Paris Est, 2014. http://www.theses.fr/2014PEST1035.

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Les réactions multicomposants sont des réactions faisant intervenir au minimum trois composés pour la préparation d'un produit contenant la majeure partie des atomes de départ. Elles constituent l'un des procédés les plus performants en synthèse organique. En diminuant les coûts et les rejets par rapport aux réactions classiques de chimie organique, elles sont également plus économes et plus respectueuses de l'environnement. De plus, en permettant la formation rapide et efficace d'une large librairie de molécules complexes à partir de substrats simples, elles représentent un outil à forte vale

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Dosta, Pons Pere. "Development of cell-specific RNAi delivery vectors based on poly(β-amino ester)s with therapeutic applications". Doctoral thesis, Universitat Ramon Llull, 2017. http://hdl.handle.net/10803/406136.

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Els ARNs de interferència han demostrat tenir un potencial terapèutic molt prometedor per tractar malalties causades per desregulació gènica. S’han estudiat i desenvolupat diferents tècniques d’alliberació d’ARNs, tot i així, els dubtes sobre la seva seguretat, especificitat cel·lular i eficiència de transfecció fan necessari el desenvolupament de metodologies d’alliberació alternatives, capaces de conduir de forma específica i segura els àcids nucleics fins a la seva diana terapèutica. Recentment, formulacions polimèriques basades en poly(β-amino ester)s (pBAEs) han sorgit com una opció pe

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Smyth, G. Darren. "Asymmetric synthesis via #beta#-amino esters." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297678.

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Oh, Sejin. "Development of mucus permeating nanoparticles-based drug delivery systems." Doctoral thesis, Universitat Ramon Llull, 2016. http://hdl.handle.net/10803/382626.

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Existeix un interès creixent, tant en el món acadèmic com en la recerca industrial en el desenvolupament de sistemes d’alliberament de fàrmacs macromoleculars (proteïnes, pèptids, oligonucleotids) capaços de travessar la mucosa. En aquest sentit, la utilització de vectors sintètics per a l’alliberament de les esmentades macromolècules, permet disposar d’una plataforma versàtil i altament eficient. Tanmateix, la capa de mucosa amb propietats adhesives i altament viscoelàstica, té una elevada capacitat d’atrapar i eliminar qualsevol substància estranya que quedi adherida sobre la seva superfície

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Strompen, Simon [Verfasser], and Andreas [Akademischer Betreuer] Liese. "Process development of a solvent-free, chemoenzymatic reaction sequence for the enantioselective synthesis of beta-amino acid esters / Simon Strompen. Betreuer: Andreas Liese." Hamburg-Harburg : Universitätsbibliothek der Technischen Universität Hamburg-Harburg, 2012. http://d-nb.info/1048542920/34.

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Book chapters on the topic "Beta-Amino ester"

1

Kozielski, Kristen L., and Jordan J. Green. "Bioreducible Poly(Beta-Amino Ester)s for Intracellular Delivery of SiRNA." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3112-5_8.

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