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Dissertations / Theses on the topic 'Beta-lactam antibiotics'

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1

Cuthbert, B. K. "Analogues of beta-lactam antibiotics." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370245.

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2

Rogers, M. E. "Beta-lactam antibiotics : Analysis and biosynthesis." Thesis, University of Westminster, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383031.

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3

Vasilenko, Sofia, and Софія Василенко. "Bacteria resistance to beta-lactam antibiotics." Thesis, National Aviation University, 2021. https://er.nau.edu.ua/handle/NAU/50637.

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1. Pulok K. Mukherjee. Quality Control and Evaluation of Herbal Drugs: Evaluating Natural Products and Traditional Medicine. Elsevier, 2019. 762 p. 2. Kumar A., Schweizer H. Bacterial resistance to antibiotics: Active efflux and reduced uptake. Adv. Drug Deliv. Rev. 2005. Vol. 57. P. 513. 3. Antimicrobial Resistance: Tackling a Crisis for the Future Health and Wealth of Nations. Chaired by Jim O’Neill. London: Review on Antimicrobial Resistance. 2014. 16 p. 4. Thomas C. M., Nielsen K.M. Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat. Rev. Microbiol. 2005. Vol. 3
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4

Hadfield, Peter Stanley. "The synthesis of #gamma#-lactam mimics of #beta#-lactam antibiotics." Thesis, University of Huddersfield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338614.

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5

Jayaweera, G. D. S. A. "Some aspects of beta-lactam chemistry." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370619.

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6

Hedberg, Maria. "[Beta]-lactam resistance in anaerobic bacteria." Stockholm : Division of Oral Microbiology, Dept. of Immunology, Microbiology, Pathology and Infectious Diseases, Hudding University Hospital, Karolinska Institute, 1995. http://catalog.hathitrust.org/api/volumes/oclc/33394040.html.

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7

Schofield, C. "Chemical and enzymatic synthesis of beta-lactam antibiotics." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355775.

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8

Freeman, Richard Neil Templar. "The total synthesis of non-beta-lactam antibiotics." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257963.

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9

Blackburn, Jonathan Michael. "Investigation into the biosynthesis of #beta#-lactam antibiotics." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303654.

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10

Bolister, Nina Jane. "The diffusion of beta-lactam antibiotics through biopolymers." Thesis, University of Brighton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328209.

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11

Harris, T. A. J. "The ion-pair extraction of beta-lactam antibiotics." Thesis, London South Bank University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279405.

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12

Badin, Sevil. "Genetic epidemiology of allergy to beta-lactam antibiotics." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/genetic-epidemiology-of-allergy-to-betalactam-antibiotics(c6571b05-3322-4662-88c4-88b300c96c9d).html.

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Background: Immediate antibiotic allergic response is an important public health problem. Genetic and molecular characterization will improve treatment outcomes for truly allergic patients, and also reduce the use (and risk of evolution of pathogen resistance) of second-line antibiotics given to patients who incorrectly believe themselves to be allergic to first-line antibiotics. Objective: To identify genetic and metabolic factors associated with allergic responses to beta-lactam antibiotics using the TwinsUK cohort and recruited participants from the Guy’s allergy clinic. Methods: The TwinsU
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13

Eley, A. R. "The response of Bacteroides species to beta-lactam antibiotics." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356555.

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14

Cox, G. "Synthesis of carbocyclic analogues of the #beta#-lactam antibiotics." Thesis, University of Huddersfield, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374894.

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15

Payne, David John. "Novel aspects of transferable resistance to beta-lactam antibiotics." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/19226.

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Until 1983, third generation cephalosporins (3GC) were thought to be resistant to hydrolysis by all plasmid-mediated β-lactamases. However, TEM and SHV derived β-lactamases have recently evolved which can confer transferable resistance to 3GC. Six novel plasmid β-lactamases, which confer transferable resistance to 3GC have been identified and characterised. They have been compared directly to the other 3GC hydrolysing β-lactamases discovered elsewhere. The criteria implemented to distinguish these different β-lactamases were: Km and Vmax values for the hydrolysis of different substrates, molec
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16

Reid, Alison Jean. "Resistance to beta-lactam antibiotics in gram-negative bacteria." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/19258.

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17

Wallace, Jeremy Iain. "Hyperinducible β-lactamase expression in gram-negative bacteria." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295568.

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18

Davis, Simon Christopher. "Studies on the cleavage of sidechains from #beta#-lactam antibiotics." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315699.

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19

Bird, Juliette W. "Biosynthetic studies on the tripeptide precursor of #beta#-lactam antibiotics." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253002.

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20

Knight, J. "New synthetic methods for the synthesis of #BETA#-lactam antibiotics." Thesis, University of Southampton, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373921.

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21

McGillivary, Angela. "Reactive solvent extraction of #beta#-lactam antibiotics and other anions." Thesis, London South Bank University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326763.

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22

Frampton, Helen Kathleen. "Studies of resistance to Beta-lactam antibiotics in Bacillus licheniformis." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328977.

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23

Sakhnini, Nina Issam. "The synthesis of novel compounds related to #beta#-lactam antibiotics." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359204.

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24

Korir, Cindy Chepngeno. "Biochemical and molecular characterization of streptococcus pneumoniae strains resistant to beta-lactam antibiotics." Diss., Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-07062004-081519/unrestricted/korir%5Fcindy%5Fc%5F200407%5Fphd.pdf.

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Thesis (Ph. D.)--School of Biology, Georgia Institute of Technology, 2005. Directed by Paul Edmonds.<br>Paul Edmonds, Committee Chair ; Steve Harvey, Committee Member ; Igor Zhulin, Committee Member ; Yury Chernoff, Committee Member ; Mostafa El-Sayed, Committee Member. Includes bibliographical references.
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25

Shah, Ajit Jesang. "The analysis of #beta#-lactams and their biosynthetic intermediates in fermentations of #beta#-lactam producing fungi." Thesis, University of Westminster, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358855.

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26

Buckwell, S. C. "The kinetics of the #beta#-lactamase catalysed hydrolysis of cephalosporins." Thesis, University of Huddersfield, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376437.

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27

Crompton, I. A. "Studies on #beta#-lactamases." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233406.

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28

Rowe, Christine Janet. "Genetic engineering of penicillin biosynthesis." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307008.

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29

Tarr, Shahida. "Using gene shuffling to increase genetic diversity in genes involved in beta-lactam biosynthesis." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1004074.

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The actinomycetes are gram-positive bacteria that produce more than two-thirds of the known biologically active microbial natural products, including many commercially important antibiotics, anti-cancer agents, other pharmacologically useful agents, animal health products and agrochemicals. The prevailing utilization of antibiotics continues to be the mainstay against microbial infections and a majority ofthe over six thousand antibiotics discovered thus far are from Streptomyces spp. One of the most well-characterized antibiotic biosynthetic pathway is the one involving the biosynthesis of th
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30

Thorburn, Christine Elaine. "The effect of pharmacokinetics on the development of bacterial resistance to antibiotics." Thesis, University of East London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359992.

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31

Gustavsson, Eva. "SPR biosensor analysis of [beta]-lactam antibiotics in milk : devoplement and use of assays based on a [beta]-lactam receptor protein /." Uppsala : Swedish Univ. of Agricultural Sciences, 2003. http://www.gbv.de/dms/bs/toc/363528245.pdf.

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32

Goh, Kee Chuan. "The biosynthesis of β-lactams". Thesis, University of Oxford, 1993. http://ora.ox.ac.uk/objects/uuid:24b6b29d-87cc-48f2-bd1b-bb64c663604f.

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This thesis reports the work done on two research projects which were carried out independently of each other but converge on the central theme of β-lactam biosynthesis. Chapter 1 provides an overview of biosynthesis in secondary metabolism, with special emphasis on current knowledge about the β-lactams. The first project, covered from Chapters 2 to 5, was part of our group's continuing effort to understand the structure and mechanism of Ring Expandase-Hydroxylase (REXH), an enzyme involved in the biosynthesis of cephalosporin C in Cephalosporium acremonium. REXH is a bifunctional enzyme, conv
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33

Kendall, Sharon. "An investigation of an anomalous response of E.coli to beta-lactam antibiotics." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336924.

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34

Wood, Jonathan. "Effects of garlic on the susceptibility of MRSA to beta-lactam antibiotics." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55864/.

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It is well recognised that resistance to antibiotics is a major global health problem which is increasing in significance year on year. Many authorities believe it to be the biggest healthcare issue of the 21st century. In particular, methicillin-resistant Staphylococcus aureus (MRSA) is a major clinical problem, particularly in the UK. Plant-derived products, and particularly garlic, have been recognised as having antimicrobial activity for centuries. This traditional use has now been substantiated by credible science. Recent studies have begun to investigate whether there is any synergism be
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35

Templey, Margaret Patricia. "The synthesis of some new heterocyclic analogues of the beta-lactam antibiotics." Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384557.

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36

Leung, Yun-Chung. "Properties of mutatant derivatives of #beta#-lactamase I from Bacillus cereus." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260180.

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37

Petersson, Ann Cathrine. "Species specific susceptibility testing for [beta]-lactam antibiotics with special reference to staphylococci /." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945092.html.

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38

Periyannan, Gopal Raj. "Characterization of the metallo-[beta]-lactamase L1 from Stenotrophomonas maltophilia." Oxford, Ohio : Miami University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1099689034.

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39

Saunders, Geoffrey Lance. "Beta-lactam antibiotic resistance in enterobacter cloacae isolated from Groot Schuur Hospital inpatients." Thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/25559.

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40

Saunders, G. L. (Geoffrey Lance). "Beta-lactam antibiotic resistance in enterobacter cloacae isolated from Groot Schuur Hospital inpatients." Master's thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/25557.

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41

Law, Ka-lun. "Synthesis of spirolactams via phenylseleno group transfer radical cyclization and secondary amine formation via reductive amination using InCl3/Et3SiH promoted by Lewis acid." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39558198.

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42

Krallis, Myrsini. "Isolation and identification of Beta-Lactam Producing Microorganisms using PCR based methodologies." Thesis, Rhodes University, 1997. http://hdl.handle.net/10962/d1018237.

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The polymerase chain reaction (PCR) was investigated as a potential tool in microbial screening for 13-lactam. producing organisms. Optimization of PCR conditions and the addition of acetamide to the PCR reaction allowed for the successful amplification of the isopenicillin N synthetase (lPNS) gene in S. clavuligerus, S. tanashiensis, S. griseus, S. olivaceus, S. lipmanii, and S. chartreusis. PCR was used to produce a radiolabelled probe from S. clavuligerus that was used to detect analogous genes in bacteria and fungi. Southern blot and dot blot analysis using the lPNS probe revealed the pres
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43

Heffernan, Aaron J. "Dose optimisation of intravenous and nebulised antibiotics for the treatment of Pseudomonas aeruginosa pneumonia." Thesis, Griffith University, 2023. http://hdl.handle.net/10072/421611.

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Ventilator-associated pneumonia remains commonplace in critically ill patients and is associated with an increased morbidity and mortality. Multidrug-resistant Gram-negative bacillary pathogens, such as Pseudomonas aeruginosa, are commonly implicated in the pathogenesis of ventilator-associated pneumonia. Increasing rates of antibiotic resistance have led to increasing interest in repurposing old antibiotics with alternative administration methods and the development of new antibiotics that have activity against these multidrug-resistant isolates. Moreover, ensuring that the optimal dose is us
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44

Wright, G. "Rapid changes in the cell envelope of Bacillus subtilis during treatment with #beta#-lactam antibiotics." Thesis, University of Kent, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380698.

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45

Li, Meng. "UTI antibiotics : mechanism of transport and in vivo interaction with cranberry juice /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/7945.

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46

Ba, Xiaoliang. "Investigation of novel mechanisms of resistance and susceptibility to [beta]-lactam antibiotics in methicillin-resistant Staphylococcus aureus." Thesis, University of Cambridge, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709481.

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47

Law, Ka-lun, and 羅嘉倫. "Synthesis of spirolactams via phenylseleno group transfer radical cyclization and secondary amine formation via reductive aminationusing InCl3/Et3SiH promoted by Lewis acid." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39558198.

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48

Deaguero, Andria Lynn. "Improving the enzymatic synthesis of semi-synthetic beta-lactam antibiotics via reaction engineering and data-driven protein engineering." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42727.

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Semi-synthetic β-lactam antibiotics are the most prescribed class of antibiotics in the world. Chemical coupling of a β-lactam moiety with an acyl side chain has dominated the industrial production of semi-synthetic β-lactam antibiotics since their discovery in the early 1960s. Enzymatic coupling of a β-lactam moiety with an acyl side chain can be accomplished in a process that is much more environmentally benign but also results in a much lower yield. The goal of the research presented in this dissertation is to improve the enzymatic synthesis of β-lactam antibiotics via reaction engineeri
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49

Wang, Danni. "Synthesis and evaluation of antibacterial activity of the dual-action agents : beta-lactamase inhibitors with cytotoxic agents or beta-lactam antibiotics." Thesis, Aston University, 2001. http://publications.aston.ac.uk/12362/.

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50

Ferreira, Juliana de Souza. "Processo intensificado de hidrolise enzimatica de penicilina G e purificação dos produtos em reator multi-estagio e contra-corrente." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267674.

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Orientadores: Telma Teixeira Franco, Adrianus Johannes Straanhof, Lucas Antonius Maria van der Wielen<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica<br>Made available in DSpace on 2018-08-05T06:02:03Z (GMT). No. of bitstreams: 1 Ferreira_JulianadeSouza_D.pdf: 5552134 bytes, checksum: f2234304e4f228a88bb1b83073350bfa (MD5) Previous issue date: 2004<br>Resumo: Este trabalho estuda a hidrólise enzimática da penicilina G (PenG) em ácido 6-aminopenicilânico (6-APA) e ácido fenil acético (PAA). Em um reator contra-corrente multi-estágio e em baixos valores
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