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Journal articles on the topic 'Beta-lactam antibiotics'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Oates, John A., Alastair J. J. Wood, Gerald R. Donowitz, and Gerald L. Mandell. "Beta-Lactam Antibiotics." New England Journal of Medicine 318, no. 7 (1988): 419–26. http://dx.doi.org/10.1056/nejm198802183180706.

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2

Oates, John A., Alastair J. J. Wood, Gerald R. Donowitz, and Gerald L. Mandell. "Beta-Lactam Antibiotics." New England Journal of Medicine 318, no. 8 (1988): 490–500. http://dx.doi.org/10.1056/nejm198802253180806.

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3

Asham, Preet Saini1 Shivam Sharma2 Tarun Sharma3 Kailash Singh Bisht*4. "Evaluation And Management Strategies for Beta-Lactam Antibiotics Induced Hypersensitivity Reactions: A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 3188–206. https://doi.org/10.5281/zenodo.15110977.

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Beta-lactam antibiotics are essential and extensively utilized medications for bacterial infections in clinical settings. Penicillin has the highest prevalence of inducing hypersensitivity reactions among beta-lactam antibiotics. This can lead to poor treatment outcomes, increased risk for antibiotic resistance, and high treatment expenses. With an increasing number of suspected cases of hypersensitivity reactions, it is essential to accurately diagnose them using sensitive skin testing and in-vitro methods, while minimizing the risk of serious adverse reactions. A thorough evaluation could ef

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4

Bradley, Nicole, Yuman Lee, and Dana Weinstein. "Overview of Beta-Lactam Allergy and the Role of the Pharmacist in Management." Allergies 1, no. 2 (2021): 128–36. http://dx.doi.org/10.3390/allergies1020011.

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Unverified beta-lactam allergies are a substantial public health problem, as the majority of patients labeled as beta-lactam allergic do not have clinically significant allergies that may hinder the use beta-lactam therapy when indicated. Outdated or inaccurate beta-lactam or penicillin allergies can result in serious consequences, including suboptimal antibiotic therapy, increased risk of adverse effects, and use of broader spectrum antibiotics than indicated, which may contribute to antimicrobial resistance. The purpose of this review is to provide an overview of beta-lactam allergy and high

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5

BALDWIN, JACK E., GREGORY P. LYNCH, and JANOS PITLIK. ".GAMMA.-Lactam analogues of .BETA.-lactam antibiotics." Journal of Antibiotics 44, no. 1 (1991): 1–24. http://dx.doi.org/10.7164/antibiotics.44.1.

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Ji, Youqi, Yinhuan Wang, Zhangkai Xu та ін. "Small Molecules from Medicinal Plant Iris tectorum as Histidine Kinase Inhibitor to Resensitize β-Lactam-Resistant Escherichia coli". Molecules 30, № 3 (2025): 663. https://doi.org/10.3390/molecules30030663.

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Background: Due to the widespread use of broad-spectrum antibiotics, the problem of antibiotic resistance has become an increasingly serious global threat. One of the key mechanisms of Escherichia coli resistance to beta-lactam antibiotics is the production of beta-lactamase enzymes, which poses a dilemma for clinicians in selecting antibiotics when faced with resistant bacterial infections. However, research on the reversal of bacterial resistance is limited. Methods: This study involved the preparation of Iris tectorum extract and detection of its effects on antibiotics sensitivity, extended

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7

Chandrasekar, Pranatharthi H., and George J. Alangaden. "Newer beta-lactam antibiotics." Current Opinion in Infectious Diseases 9, no. 6 (1996): 391–97. http://dx.doi.org/10.1097/00001432-199612000-00006.

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8

Semizhon, P. A., H. P. Scheslenok, I. V. Harbachova, I. I. Vashkevich, and O. V. Sviridov. "MONITORING OF BIOLOGICAL ACTIVITY OF BETA-LACTAM ANTIBIOTICS RECEPTOR BLAR-CTD IN THE PROCESSES OF ITS HETEROLOGICAL EXPRESSION, PURIFICATION AND APPLICATION IN ANALYTICAL SYSTEMS." http://eng.biomos.ru/conference/articles.htm 1, no. 19 (2021): 246–48. http://dx.doi.org/10.37747/2312-640x-2021-19-246-248.

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To develop the technologies of beta-lactam antibiotics bioassays in foods, high purity beta-lactam receptor BlaR-CTD has been obtained and characterized. A test system for the quantitation of the biologically active and immunoreactive receptor in the processes of its heterological expression, isolation and reagent forms preparation was elaborated. The immunochemical properties and antibiotic binding ability of BlaR-CTD were investigated, and the constructions and application procedures of receptor-immune systems for the assay of beta-lactam antibiotics using microplates or chromatographic test

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9

Mukhsinov, Farkhod Munisovich, and Irina Vladimirovna Liverko. "PHENOTYPIC PREDICTORS AND BIOMARKERS FOR FORECASTING THE EFFECTIVENESS OF ANTIMICROBIAL THERAPY." journal of cardiorespiratory research 3, no. 3 (2022): 3. https://doi.org/10.5281/zenodo.7145906.

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According to the results, it was found that the serum beta-lactamase activity level is determined by phenotypic and clinical variables: age over 60 years, severe respiratory pathology, fever over 380 , peripheral blood leukocyte level over 10x109, C-reactive protein over 40 mg/L and saturation less than 93%, correlating with an increase in UAV levels, and are predictors of low efficacy of treatment with beta-lactam antibiotics. A direct correlation was revealed between the level of serum beta-lactamase activity and the duration of antimicrobial therapy during the year (r=+0.86, p=0.001), the n

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Asada, K., Y. Inaba, E. Tateda-Suzuki, K. Kuwahara-Arai, T. Ito, and K. Hiramatsu. "Evolution and resistance expression of MRSA. Evaluation of beta-lactam antibiotics against a set of isogenic strains with different types of phenotypic expression." Acta Biochimica Polonica 42, no. 4 (1995): 517–24. http://dx.doi.org/10.18388/abp.1995_4905.

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Methicillin-resistant Staphylococcus aureus (MRSA) has two mechanisms of resistance to beta-lactam antibiotics; one is mediated by mecA gene expression, and the other by penicillinase production. It has been generally accepted in the clinical field that beta-lactam antibiotics are not the drugs of choice for MRSA infection. In this report, however, ampicillin and penicillin G were shown to have relatively good activity against MRSA if combined with a beta-lactamase inhibitor, sulbactam. These beta-lactam antibiotics were found to have relatively high binding affinities to PBP2', the mecA-encod

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11

Abd, Luma Salman. "Historical Review of the Penicillin and Related Compounds (β – Lactams)". Al Mustansiriyah Journal of Pharmaceutical Sciences 18, № 1 (2018): 109–27. http://dx.doi.org/10.32947/ajps.v18i1.464.

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In spite of the old age of beta lactam, they continue to provide good health and preventing human diseases by virtue of industrial production and discoveries of small new beta-lactam group of secondary metabolite. Antibiotic resistance in bacteria has become a serious problem worldwide therefore, the present survey discusses the event that occurred in the progress of the penicillin, and beta-lactam from discovery to implementation as a therapeutic agent in order to overcome this issue . Moreover, this review provides a descriptive overview of the various published ways to enhance the clinical

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Gozali, Cynthia, and Conny Riana Tjampakasari. "Pseudomonas aeruginosa biofilm formation and its resistance to beta-lactam antibiotics." Damianus Journal of Medicine 22, no. 2 (2023): 162–72. http://dx.doi.org/10.25170/djm.v22i2.3928.

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ABSTRACT Introduction: An opportunistic pathogen, Pseudomonas aeruginosa is a Gram-negative bacteria that causes acute and chronic human infections. By adhering to appropriate surfaces and creating a biofilm matrix, Pseudomonas aeruginosa has a high-resistance structure. Due to biofilm resistance mechanisms, this bacterial biofilm may increase natural antibiotic resistance. Antibiotics have difficulty penetrating the exopolysaccharide matrix that makes up the biofilm structure (Psl, Pe, alginate, and eDNA). Alginate is involved in generating mucus, and Psl and Pel components are implicated in

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13

Kryukova, D., A. Sokolov, and Maksim Maksimov. "Pharmacology of inhibitor-protected beta-lactam agents." Novejshie zarubezhnye i otechestvennye lekarstvennye preparaty: farmakoterapija, farmakodinamika, farmakokinetika (Newest Foreign and Domestic Preparations: Pharmacotherapy, Pharmacodynamics, Pharmacokinetics), no. 3 (June 1, 2020): 53–69. http://dx.doi.org/10.33920/med-06-2003-05.

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Beta-lactam antibiotics are the most widely used class of antibacterial drugs, both for outpatient and hospital infections. Their further improvement in relation to overcoming the resistance of microorganisms to this group of antibiotics has given new opportunities in the treatment of severe infectious diseases. Due to the obtained high efficiency of β-lactam antibiotics and their low toxicity, they form the basis of antimicrobial chemotherapy at present. Antibiotic resistance is the phenomenon of resistance of a stain of infectious agents to the action of one or more antibacterial drugs. It i

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14

Leanza, Gabriele Maria, Beatrice Liguoro, Simone Giuliano, et al. "The Subcutaneous Administration of Beta-Lactams: A Case Report and Literary Review—To Do Small Things in a Great Way." Infectious Disease Reports 16, no. 1 (2024): 93–104. http://dx.doi.org/10.3390/idr16010007.

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The subcutaneous (s.c.) route is a commonly used method for delivering various drugs, although its application in the administration of antibiotics is relatively uncommon. In this case, we report a successful treatment of nosocomial pneumonia using piperacillin/tazobactam via continuous subcutaneous administration. Furthermore, this article provides an overview of the current literature regarding the s.c. administration of beta-lactam antibiotics. Based on our analysis, we identified only 15 studies that described the s.c. use of beta-lactam antibiotics in human subjects. Among these studies,

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15

Ahsan, Sunjukta, Anindita Bhowmik, Sharmistha Goswami, and Nasir Uddin. "Detection of New Delhi Metallo b Lactamase gene in Uropathogenic E. coli." Bangladesh Journal of Microbiology 36, no. 1 (2019): 29–33. http://dx.doi.org/10.3329/bjm.v36i1.44280.

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The rapid dissemination of antibiotic resistant E. coli is now a worldwide problem. In this study, a total of twenty E. coli obtained from stool were selected to determine resistance to beta lactam antibiotics. Beta–Lactamase are enzymes produced by bacteria that provide multi resistance to beta lactam antibiotics such as penicillin, cephalosporin, cephamycin and carbapenems. Of these isolates (n = 20), 35% were found resistant to Amoxicillin Clavulanate, 5% to Imipenem, 50% to Ceftriaxone and 75% to Ampicillin. PCR amplification confirmed the presence of the New Delhi beta-lactamase gene (bla

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16

Ghiska Ma’alia Yusuf and Musa Fitri Fatkhiya. "Pengetahuan Pasien Terhadap Adverse Drug Reactions (ADRs) Penggunaan Obat Antibiotik Beta-Laktam di RSUD Bendan Tahun 2024." OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan 3, no. 3 (2025): 135–44. https://doi.org/10.61132/obat.v3i3.1295.

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Knowledge is the result of the process of understanding and recognizing something obtained through sensing an object. Beta-lactam antibiotics are a type of broad-spectrum antibiotic commonly used to treat bacterial infections, but their use still has the potential to cause side effects in the form of Adverse Drug Reactions (ADRs). This study aims to assess the level of patient knowledge regarding ADRs due to the use of beta-lactam antibiotics at Bendan Pekalongan Regional Hospital in 2024. This study used a prospective correlation design with a non-experimental approach. A total of 29 outpatie

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17

Vondracek, Thomas G. "Beta-Lactam Antibiotics: Is Continuous Infusion The Preferred Method of Administration?" Annals of Pharmacotherapy 29, no. 4 (1995): 415–24. http://dx.doi.org/10.1177/106002809502900413.

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Objective: To examine the pharmacodynamic properties of the beta-lactam class of antibiotics and the rationale for their continuous infusion (CI), and to explore reasons that this mode of administration has not replaced intermittent infusion as the standard of practice. Data Sources: A MEDLINE search of the English-language literature evaluating CI administration of beta-lactam antibiotics was conducted. Bibliographic searches of these articles also were performed. Study Selection: Because there were few human trials, all available trials were considered for review. A cross section of clinical

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18

Dhaese, Sofie A. M., Eric A. Hoste, and Jan J. De Waele. "Why We May Need Higher Doses of Beta-Lactam Antibiotics: Introducing the ‘Maximum Tolerable Dose’." Antibiotics 11, no. 7 (2022): 889. http://dx.doi.org/10.3390/antibiotics11070889.

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The surge in antimicrobial resistance and the limited availability of new antimicrobial drugs has fueled the interest in optimizing antibiotic dosing. An ideal dosing regimen leads to maximal bacterial cell kill, whilst minimizing the risk of toxicity or antimicrobial resistance. For beta-lactam antibiotics specifically, PK/PD-based considerations have led to the widespread adoption of prolonged infusion. The rationale behind prolonged infusion is increasing the percentage of time the beta-lactam antibiotic concentration remains above the minimal inhibitory concentration (%fT>MIC). The ulti

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19

Gun, Mehmet Akif, Bulent Bozdogan, and Ahmet Yilmaz Coban. "Tuberculosis and beta-lactam antibiotics." Future Microbiology 15, no. 10 (2020): 937–44. http://dx.doi.org/10.2217/fmb-2019-0318.

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Tuberculosis (TB) is one of the oldest health problems in the world and it remains unresolved. Multidrug-resistant-TB and extensively resistant-TB are a serious problem for control programs. The evaluation of available antibiotics has gained importance in recent years for the treatment of resistant TB. Beta-lactam antibiotics inhibit cell wall biosynthesis in the bacteria; the presence of beta-lactamase enzyme in TB bacilli raises the question of whether this group of antibiotics can be used in treatment. As a result, it has been reported that the combination of beta-lactam antibiotics with be

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20

Stašek, Jan, Filip Keller, Veronika Kočí, et al. "Update on Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Critically Ill Patients—A Narrative Review." Antibiotics 12, no. 3 (2023): 568. http://dx.doi.org/10.3390/antibiotics12030568.

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Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care due to their excellent safety profiles and their activity against a wide spectrum of pathogens. The cornerstone of appropriate therapy with beta-lactams is to achieve an adequate plasmatic concentration of a given antibiotic, which is derived primarily from the minimum inhibitory concentration (MIC) of the specific pathogen. In a critically ill patient, the plasmatic levels of drugs could be affected by many significant changes in the patient’s physiology, such as hypoalbuminemia, endothelial dysfun

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21

Legg, Amy, Sinead Carmichael, Ming G. Chai, Jason A. Roberts, and Menino O. Cotta. "Beta-Lactam Dose Optimisation in the Intensive Care Unit: Targets, Therapeutic Drug Monitoring and Toxicity." Antibiotics 12, no. 5 (2023): 870. http://dx.doi.org/10.3390/antibiotics12050870.

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Beta-lactams are an important family of antibiotics used to treat infections and are commonly used in critically ill patients. Optimal use of these drugs in the intensive care unit (ICU) is important because of the serious complications from sepsis. Target beta-lactam antibiotic exposures may be chosen using fundamental principles of beta-lactam activity derived from pre-clinical and clinical studies, although the debate regarding optimal beta-lactam exposure targets is ongoing. Attainment of target exposures in the ICU requires overcoming significant pharmacokinetic (PK) and pharmacodynamic (

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22

Vitus Silago. "Beta-lactam antibiotics and extended spectrum beta-lactamases." GSC Advanced Research and Reviews 9, no. 2 (2021): 015–24. http://dx.doi.org/10.30574/gscarr.2021.9.2.0200.

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Extended spectrum beta-lactamases (ESBLs) are enzymes produced by bacteria, mostly members of the family Enterobacteriaceae commonly Escherichia coli and Klebsiella pneumoniae. ESBLs hydrolyze the beta-lactam ring of beta-lactam antibiotics making these antibiotics ineffective therefore rendering the bacteria resistance against beta-lactam antibiotics. The global upsurge of ESBLs producing bacteria causing both hospital and community acquired infections mostly urinary tract infections, pneumonia and bloodstream infections, threatens the effectiveness of infectious diseases treatment. ESBL fami

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23

Vitus, Silago. "Beta-lactam antibiotics and extended spectrum beta-lactamases." GSC Advanced Research and Reviews 9, no. 2 (2021): 015–24. https://doi.org/10.5281/zenodo.5763461.

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Extended spectrum beta-lactamases (ESBLs) are enzymes produced by bacteria, mostly members of the family Enterobacteriaceae commonly <em>Escherichia coli</em> and <em>Klebsiella pneumoniae</em>. ESBLs hydrolyze the beta-lactam ring of beta-lactam antibiotics making these antibiotics ineffective therefore rendering the bacteria resistance against beta-lactam antibiotics. The global upsurge of ESBLs producing bacteria causing both hospital and community acquired infections mostly urinary tract infections, pneumonia and bloodstream infections, threatens the effectiveness of infecti

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24

Fatina, Naila, and Musa Fitri Fatkhiya. "HUBUNGAN KEPATUHAN DENGAN KEJADIAN ADVERSE DRUG REACTIONS (ADRS) PADA PENGGUNAAN ANTIBIOTIK BETA-LAKTAM DI RSUD BENDAN KOTA PEKALONGAN." BENZENA Pharmaceutical Scientific Journal 3, no. 02 (2024): 10–23. https://doi.org/10.31941/benzena.v3i02.5516.

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Background: Beta-lactam antibiotics are one of the most common drugs to treat bacterial infections. Although effective, the use of these antibiotics can cause Adverse Drug Reactions (ADRs), potentially affecting patient compliance with treatment. Non-adherence in the use of antibiotics can have a negative impact on therapeutic outcomes, including an increased risk of ADRs. Objective: The research aims to determine the relationship between compliance and the incidence of ADRs in the use of beta-lactam antibiotics at Bendan Hospital, Pekalongan City. Method: This research used prospective method

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Escalona, José, Dagoberto Soto, Vanessa Oviedo, et al. "Beta-Lactam Antibiotics Can Be Measured in the Exhaled Breath Condensate in Mechanically Ventilated Patients: A Pilot Study." Journal of Personalized Medicine 13, no. 7 (2023): 1146. http://dx.doi.org/10.3390/jpm13071146.

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Different techniques have been proposed to measure antibiotic levels within the lung parenchyma; however, their use is limited because they are invasive and associated with adverse effects. We explore whether beta-lactam antibiotics could be measured in exhaled breath condensate collected from heat and moisture exchange filters (HMEFs) and correlated with the concentration of antibiotics measured from bronchoalveolar lavage (BAL). We designed an observational study in patients undergoing mechanical ventilation, which required a BAL to confirm or discard the diagnosis of pneumonia. We measured

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Syromyatnikov, M. Yu, S. V. Shabunin, E. Yu Nesterova, et al. "ANALYSIS OF ANTIBIOTIC RESISTANCE GENES OF ESCHERICHIA COLI FROM THE GUT OF THE PIGLETS WITH DIARRHEA." Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine 60, no. 2 (2024): 95–100. http://dx.doi.org/10.52368/2078-0109-2024-60-2-95-100.

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The study is devoted to the analysis of the prevalence of antibiotic resistance genes in cultures of E. coli isolated from the gut of the piglets with diarrhea. With the use of high-throughput sequencing, it was possible to identify 26 antibiotic resistance genes. They belonged to 7 groups of antibiotics: aminoglycosides, beta-lactam antibiotics, quinolones, sulfonamides, tetracyclines, diaminopyrimidine, phenicols. The relative abundance of the QnrD gene was maximal in the studied sample of E. coli isolates (50%). For other sequences of antibiotic resistance genes, the percentage ratio of eac

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Göncüoğlu, Cansu, Emre Kara, Kutay Demirkan, A. Fuat Kalyoncu, and Serhat Ünal. "Beta-laktam Antibiyotiklere Karşı Gelişen Aşırı Duyarlılık Reaksiyonları." Flora the Journal of Infectious Diseases and Clinical Microbiology 26, no. 1 (2021): 23–33. http://dx.doi.org/10.5578/flora.20219903.

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28

Sato, Masanori, Noriko Kubota, Yoshihiko Katsuyama, et al. "Case report of a 6-year-old girl with Mycoplasma hominis ventriculoperitoneal shunt infection." Journal of Neurosurgery: Pediatrics 19, no. 5 (2017): 620–24. http://dx.doi.org/10.3171/2017.1.peds16520.

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Mycoplasma hominis is a rare causative pathogen for surgical site infections after neurosurgical procedures. This organism lacks a cell wall, rendering it undetectable by Gram staining and making it resistant to beta-lactam antibiotics. In addition, some special techniques are required to identify this organism. Thus, it is very difficult to diagnose infections caused by this pathogen. Here, the authors report a pediatric case of M. hominis ventriculoperitoneal shunt (VPS) infection with central nervous system involvement for which beta-lactam antibiotics were not effective and Gram staining r

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Sandoe, Jonathan A. T., Kordo Saeed, Achyut Guleri, et al. "Opportunities for antimicrobial stewardship in patients with acute bacterial skin and skin structure infections who are unsuitable for beta-lactam antibiotics: a multicenter prospective observational study." Therapeutic Advances in Infectious Disease 6 (January 2019): 204993611882365. http://dx.doi.org/10.1177/2049936118823655.

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Purpose: The objective of this prospective, observational study was to describe the treatment, severity assessment and healthcare resources required for management of patients with acute bacterial skin and skin structure infections who were unsuitable for beta-lactam antibiotic treatments. Methods: Patients were enrolled across five secondary care National Health Service hospitals. Eligible patients had a diagnosis of acute bacterial skin and skin structure infection and were considered unsuitable for beta-lactam antibiotics (e.g. confirmed/suspected methicillin-resistant Staphylococcus aureus

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SADEGHI DEYLAMDEH, Zahra, and Abolfazl JAFARI SALES. "Evaluation of the presence of AmpC (FOX) beta-lactamase gene in clinical strains of Escherichia coli isolated from hospitalized patients in Tabriz, Iran." Journal of Experimental and Clinical Medicine 38, no. 3 (2021): 301–4. http://dx.doi.org/10.52142/omujecm.38.3.17.

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Beta-lactamases are the most common cause of bacterial resistance to beta-lactam antibiotics. AmpC-type beta-lactamases hydrolyze cephalosporins, penicillins, and cephamycins. Therefore, the study aims was to determine antibiotic resistance and to investigate the presence of AmpC beta-lactamase gene in clinical strains of Escherichia coli isolated from hospitalized patients in Tabriz. In this cross-sectional descriptive study, 289 E. coli specimens were collected from clinical specimens. Disk diffusion method and combined disk method were used to determine the phenotype of extended spectrum β-

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Salamone, Francine R. "Sulbactam/Ampicillin." Infection Control & Hospital Epidemiology 9, no. 7 (1988): 323–27. http://dx.doi.org/10.1086/645863.

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Sulbactam/ampicillin was recently marketed for use in several infections caused by beta-lactamase-producing organisms. Sulbactam is the second beta-lactamase inhibitor to become available in the United States. Interest in inhibition of beta-lactamases arose in the late 1960s when a combination consisting of an antibacterial agent and an enzyme inhibitor was found effective in the treatment of certain resistant gram-negative infections. It is now well accepted that the addition of a beta-lactamase inhibitor to a beta-lactam antibiotic may expand its usefulness in a variety of infections.The pen

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Wieringa, André, Tim M. J. Ewoldt, Ravish N. Gangapersad, et al. "Predicting Beta-Lactam Target Non-Attainment in ICU Patients at Treatment Initiation: Development and External Validation of Three Novel (Machine Learning) Models." Antibiotics 12, no. 12 (2023): 1674. http://dx.doi.org/10.3390/antibiotics12121674.

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In the intensive care unit (ICU), infection-related mortality is high. Although adequate antibiotic treatment is essential in infections, beta-lactam target non-attainment occurs in up to 45% of ICU patients, which is associated with a lower likelihood of clinical success. To optimize antibiotic treatment, we aimed to develop beta-lactam target non-attainment prediction models in ICU patients. Patients from two multicenter studies were included, with intravenous intermittent beta-lactam antibiotics administered and blood samples drawn within 12–36 h after antibiotic initiation. Beta-lactam tar

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Krey, Steven C., Jeff Waise, and Lee P. Skrupky. "Confronting the Challenge of Beta-Lactam Allergies: A Quasi-Experimental Study Assessing Impact of Pharmacy-Led Interventions." Journal of Pharmacy Practice 32, no. 2 (2017): 139–46. http://dx.doi.org/10.1177/0897190017743154.

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Objective: To improve allergy history documentation and increase the use of beta-lactams when appropriate in patients with a reported beta-lactam allergy. Methods: This pre–post study was conducted at a 167-bed tertiary care community hospital and evaluated multidisciplinary interventions on allergy documentation and antibiotic selection. Interventions included education, creation of local practice guidelines, and modified practices for pharmacists and pharmacy technicians. Inpatients with a reported beta-lactam allergy receiving at least 1 antibiotic for >24 hours were included; first admi

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Wong, Tiffany, Adelle Atkinson, Geert t’Jong, Michael J. Rieder, Edmond S. Chan, and Elissa M. Abrams. "Beta-lactam allergy in the paediatric population." Paediatrics & Child Health 25, no. 1 (2020): 62. http://dx.doi.org/10.1093/pch/pxz179.

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Abstract Beta-lactam allergy is commonly diagnosed in paediatric patients, but over 90% of individuals reporting this allergy are able to tolerate the medications prescribed after evaluation by an allergist. Beta-lactam allergy labels are associated with negative clinical and administrative outcomes, including use of less desirable alternative antibiotics, longer hospitalizations, increasing antibiotic-resistant infections, and greater medical costs. Also, children with true IgE-mediated allergy to penicillin medications are often advised to avoid all beta-lactam antibiotics, including cephalo

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Imburgia, Taylor A., and Michelle L. Kussin. "A Review of Extended and Continuous Infusion Beta-Lactams in Pediatric Patients." Journal of Pediatric Pharmacology and Therapeutics 27, no. 3 (2022): 214–27. http://dx.doi.org/10.5863/1551-6776-27.3.214.

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Intravenous beta-lactam antibiotics are the most prescribed antibiotic class in US hospitalized patients of all ages; therefore, optimizing their dosing is crucial. Bactericidal killing is best predicted by the time in which beta-lactam drug concentrations are maintained above the organism's minimum inhibitory concentration (MIC), rather than achievement of a high peak concentration. As such, administration of beta-lactam antibiotics via extended or continuous infusions over a minimum of 3 hours, rather than standard infusions over approximately 30 minutes, has been associated with improved ac

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Chen, Melanie, Valerie Buurma, Monica Shah, and Germin Fahim. "Evaluation of studies on extended versus standard infusion of beta-lactam antibiotics." American Journal of Health-System Pharmacy 76, no. 18 (2019): 1383–94. http://dx.doi.org/10.1093/ajhp/zxz154.

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AbstractPurposeTo summarize the current literature on the use and clinical efficacy of extended-infusion (EI) beta-lactam antibiotics, including piperacillin–tazobactam, meropenem, and cefepime.SummaryGram-negative infections are a serious concern among hospitalized patients and require innovative pharmacokinetic dosing strategies to achieve clinical success, especially as the emergence of resistant gram-negative pathogens has outpaced the development of new antibiotics. Beta-lactam antibiotics exhibit time-dependent activity, which means that optimal efficacy is achieved when free drug concen

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Vega Harwood, Alicia Wendy, Marta Martín Fernández, Carlos Ezquer Garin, et al. "Antimicrobial Dosing During Continuous Venovenous Hemodiafiltration in Septic Shock Patients: A Prospective, Multicenter Study Protocol." Antibiotics 14, no. 4 (2025): 420. https://doi.org/10.3390/antibiotics14040420.

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Background: Sepsis is a major global health issue and the leading cause of death in critically ill patients, with rising incidence and associated healthcare costs. Early administration of antibiotic therapy is crucial, but increasing antibiotic resistance poses a threat. Beta-lactam antibiotics, commonly used as a first-line therapy option against sepsis, often demonstrate unpredictable concentrations due to pharmacokinetic and pharmacodynamic changes in critically ill patients. Acute kidney injury (AKI) affects a significant portion of septic patients, and continuous renal replacement therapy

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Anago, Eugenie, Irène Winsou, Wassiyath Moussé, and Salomon Fiogbé. "Spectrophotometric Detection of Beta-Lactamase Inhibition by Plant Extracts." International Journal of Biochemistry Research & Review 34, no. 1 (2025): 1–10. https://doi.org/10.9734/ijbcrr/2025/v34i1944.

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Background: Antibiotic-resistant bacteria have been spreading with increasing frequency over the past several decades. The decreasing effectiveness of therapies in treating bacterial resistance, due to the production of beta-lactamase (EC.3.5.2.6), has led to combining beta-lactamase inhibitors with commonly used beta-lactam antibiotics. Phytochemical compounds produced by plants have varied biological properties such as antioxidant, antimicrobial, antidiabetic, anti-inflammatory, anticancer, antihypertensive and others. Polyphenolics, flavonoids, coumarins, alkaloids, tannins, steroids and te

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Del Favero, Albano. "Beta-Lactam Antibiotics and Vitamin K." Annals of Internal Medicine 116, no. 12_Part_1 (1992): 1034. http://dx.doi.org/10.7326/0003-4819-116-12-1034_2.

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Tumskaia, A. V., and I. V. Kosyreva. "Rapid Determination of Beta-Lactam Antibiotics." Journal of Analytical Chemistry 77, no. 8 (2022): 981–86. http://dx.doi.org/10.1134/s1061934822080172.

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Tumskaia, A. V., and I. V. Kosyreva. "Rapid Determination of Beta-Lactam Antibiotics." Journal of Analytical Chemistry 77, no. 8 (2022): 981–86. http://dx.doi.org/10.1134/s1061934822080172.

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James, Christopher W., and Cheryle Gurk-Turner. "Cross-Reactivity of Beta-Lactam Antibiotics." Baylor University Medical Center Proceedings 14, no. 1 (2001): 106–7. http://dx.doi.org/10.1080/08998280.2001.11927741.

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Craig, W. A., and S. C. Ebert. "Continuous infusion of beta-lactam antibiotics." Antimicrobial Agents and Chemotherapy 36, no. 12 (1992): 2577–83. http://dx.doi.org/10.1128/aac.36.12.2577.

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Keys, Thomas F. "Beta-Lactam Antibiotics for Clinical Use." Therapeutic Drug Monitoring 9, no. 1 (1987): 126. http://dx.doi.org/10.1097/00007691-198703000-00023.

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Nedbalcova, K., K. Nechvatalova, L. Pokludova, et al. "Resistance to selected beta-lactam antibiotics." Veterinary Microbiology 171, no. 3-4 (2014): 328–36. http://dx.doi.org/10.1016/j.vetmic.2014.02.004.

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Martens, Mark G., Sebastian Faro, and Lou Ellen Phillips. "Beta-lactam antibiotics and Chlamydia trachomatis." Antimicrobic Newsletter 4, no. 3 (1987): 20–23. http://dx.doi.org/10.1016/0738-1751(87)90015-3.

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Stille, W. "Positioning of the beta-lactam antibiotics." Infection 13, S1 (1985): S7—S8. http://dx.doi.org/10.1007/bf01644209.

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BORISH, L., R. TAMIR, and L. ROSENWASSER. "Itravenous desensitization to beta-lactam antibiotics." Journal of Allergy and Clinical Immunology 80, no. 3 (1987): 314–19. http://dx.doi.org/10.1016/0091-6749(87)90037-6.

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Solensky, Roland. "Hypersensitivity Reactions to Beta-Lactam Antibiotics." Clinical Reviews in Allergy & Immunology 24, no. 3 (2003): 201–20. http://dx.doi.org/10.1385/criai:24:3:201.

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Stam, John G. "Beta-lactam antibiotics for clinical use." Journal of Pharmaceutical Sciences 76, no. 10 (1987): 856. http://dx.doi.org/10.1002/jps.2600761023.

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