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Journal articles on the topic 'Beta-prism I fold lectins'

Author: Grafiati

Published: 6 September 2023

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1

Sivaji, N., K. V. Abhinav, and M. Vijayan. "Crystallization and biochemical characterization of an archaeal lectin fromMethanococcus voltaeA3." Acta Crystallographica Section F Structural Biology Communications 73, no. 5 (2017): 300–304. http://dx.doi.org/10.1107/s2053230x17006173.

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A lectin fromMethanococcus voltaeA3 has been cloned, expressed, purified and characterized. The lectin appears to be specific for complex sugars. The protein crystallized in a tetragonal space group, with around 16 subunits in the asymmetric unit. Sequence comparisons indicate the lectin to have a β-prism I fold, with poor homology to lectins of known three-dimensional structure.

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2

Ogawa, Tomohisa, Rie Sato, Takako Naganuma, et al. "Diversified Biomineralization Roles of Pteria penguin Pearl Shell Lectins as Matrix Proteins." International Journal of Molecular Sciences 22, no. 3 (2021): 1081. http://dx.doi.org/10.3390/ijms22031081.

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Previously, we isolated jacalin-related lectins termed PPL2, PPL3 (PPL3A, 3B and 3C) and PPL4 from the mantle secretory fluid of Pteria penguin (Mabe) pearl shell. They showed the sequence homology with the plant lectin family, jacalin-related β-prism fold lectins (JRLs). While PPL3s and PPL4 shared only 35%–50% homology to PPL2A, respectively, they exhibited unique carbohydrate binding properties based on the multiple glycan-binding profiling data sets from frontal affinity chromatography analysis. In this paper, we investigated biomineralization properties of these lectins and compared their

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3

Abhinav, Koyamangalath Vadakkepat, and Mamannamana Vijayan. "Structural diversity and ligand specificity of lectins. The Bangalore effort." Pure and Applied Chemistry 86, no. 9 (2014): 1335–55. http://dx.doi.org/10.1515/pac-2014-0607.

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AbstractStructural studies in this laboratory encompass four of the five major classes of plant lectins, including the one discovered by us. In addition to addressing issues specific to individual lectins, the work provided insights into protein folding, quaternary association and generation of ligand specificity. Legume and β-prism fold lectins constitute families of proteins in which small alterations in essentially the same tertiary structure lead to large variations in quaternary structure, including that involving an open structure. Strategies for generating ligand specificity include wat

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4

Wood, Stephen D., Lisa M. Wright, Colin D. Reynolds, et al. "Structure of the native (unligated) mannose-specific bulb lectin from Scilla campanulata (bluebell) at 1.7 Å resolution." Acta Crystallographica Section D Biological Crystallography 55, no. 7 (1999): 1264–72. http://dx.doi.org/10.1107/s0907444999005326.

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The X-ray crystal structure of native Scilla campanulata agglutinin, a mannose-specific lectin from bluebell bulbs and a member of the Liliaceae family, has been determined by molecular replacement and refined to an R value of 0.186 at 1.7 Å resolution. The lectin crystallizes in space group P21212 with unit-cell parameters a = 70.42, b = 92.95, c = 46.64 Å. The unit cell contains eight protein molecules of Mr = 13143 Da (119 amino-acid residues). The asymmetric unit comprises two chemically identical molecules, A and B, related by a non-crystallographic twofold axis perpendicular to c. This d

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5

Sharma, Alok, Divya Chandran, Desh D. Singh та M. Vijayan. "Multiplicity of carbohydrate-binding sites in β-prism fold lectins: occurrence and possible evolutionary implications". Journal of Biosciences 32, S2 (2007): 1089–110. http://dx.doi.org/10.1007/s12038-007-0111-3.

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6

Sharma, Alok, та Mamannamana Vijayan. "Quaternary association in β-prism I fold plant lectins: Insights from X-ray crystallography, modelling and molecular dynamics". Journal of Biosciences 36, № 5 (2011): 793–808. http://dx.doi.org/10.1007/s12038-011-9166-2.

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7

Cornil, I., R. S. Kerbel, and J. W. Dennis. "Tumor cell surface beta 1-4-linked galactose binds to lectin(s) on microvascular endothelial cells and contributes to organ colonization." Journal of Cell Biology 111, no. 2 (1990): 773–81. http://dx.doi.org/10.1083/jcb.111.2.773.

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Cell surface carbohydrate structures acting as ligands for tissue specific mammalian lectins have been implicated in cell-cell interactions during embryogenesis, lymphocyte homing, and tumor cell metastasis. In this report, we provide evidence that beta 1-4 linked galactose (Gal) residues in N-linked oligosaccharides on the surface of blood born tumor cells serve as a ligand for binding to microvascular endothelial cells. D36W25, a class 1 glycosylation mutant of the MDAY-D2 lymphoreticular tumor cell line, lacks sialic acid and Gal in cellular glycans due to a defect in the Golgi UDP-Gal tran

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8

Naganuma, Takako, Wataru Hoshino, Yukihiro Shikanai та ін. "Novel Matrix Proteins of Pteria penguin Pearl Oyster Shell Nacre Homologous to the Jacalin-Related β-Prism Fold Lectins". PLoS ONE 9, № 11 (2014): e112326. http://dx.doi.org/10.1371/journal.pone.0112326.

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9

Kumazawa-Inoue, Kaori, Tomoko Mimura, Sachiko Hosokawa-Tamiya та ін. "ZG16p, an animal homolog of β-prism fold plant lectins, interacts with heparan sulfate proteoglycans in pancreatic zymogen granules". Glycobiology 22, № 2 (2011): 258–66. http://dx.doi.org/10.1093/glycob/cwr145.

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10

Clerch, L. B., P. L. Whitney, and D. Massaro. "Rat lung lectin synthesis, degradation and activation. Developmental regulation and modulation by dexamethasone." Biochemical Journal 245, no. 3 (1987): 683–90. http://dx.doi.org/10.1042/bj2450683.

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Soluble lectins are widely distributed cell-agglutinating proteins. Their activity is developmentally regulated in several tissues, including the lung, but virtually nothing is known about the mechanisms of the developmental regulation or the turnover of these proteins. We studied mechanisms that might be responsible for the developmentally regulated changes in the activity of a lectin (beta-galactoside-binding protein) found in the lung, and determined if its activity or turnover could be modulated by treatment of rat pups with a glucocorticosteroid hormone (dexamethasone). Our studies on the

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11

Cook, R. G., N. F. Landolfi, V. Mehta, J. Leone, and D. Hoyland. "Interleukin 2 mediates an alteration in the T200 antigen expressed on activated B lymphocytes." Journal of Immunology 139, no. 4 (1987): 991–97. http://dx.doi.org/10.4049/jimmunol.139.4.991.

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Abstract We have examined the effect of exogenous IL 2 on cell surface antigen expression in LPS/dextran sulfate-activated murine B cells with the use of a panel of fluorescein-conjugated lectins. Elevated binding of the lectins PNA and SBA to activated B cells was found to be mediated by IL 2-containing supernatants from stimulated EL4 cells as well as by recombinant IL 2. These lectins have specificity for terminal beta-(1-3)-N-acetylgalactosaminyl residues; thus, the quantity or accessibility of these moieties is mediated by IL 2 in activated B lymphocytes. PNA binding in all strains tested

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12

Sharma, Alok, та Mamannamana Vijayan. "Influence of glycosidic linkage on the nature of carbohydrate binding in β-prism I fold lectins: An X-ray and molecular dynamics investigation on banana lectin–carbohydrate complexes". Glycobiology 21, № 1 (2010): 23–33. http://dx.doi.org/10.1093/glycob/cwq128.

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13

Glavey, Siobhan V., Stephen Cunningham, Laura S. Murillo, et al. "Glycosylation-Related Gene Expression Is Dysregulated in Multiple Myeloma and Overexpression of the Sialyltransferase ST3GAL6 Is Associated with Inferior Survival." Blood 120, no. 21 (2012): 2931. http://dx.doi.org/10.1182/blood.v120.21.2931.2931.

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Abstract Abstract 2931 Background Alterations in glycosylation are associated with malignant transformation, with growing evidence implicating the dysregulation of glycosylation genes (glyco-genes) in multiple myeloma (MM). P selectin glycoprotein ligand-1 (PSGL1), recently reported to be important in MM cell adhesion and trafficking is over expressed by MM cells. Importantly, the generation of functional selectin ligands requires post-translational modification of scaffold proteins by glycosyltransferases and sialyltransferases generating selectin ligands such as Sialyl Lewis X (sLex). This b

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14

Eluka-Okoludoh, Eboghoye, Kingsley Ekwemalor, Sarah Adjei-Fremah, Bharath Mulakala, and Mulumebet Worku. "Galectin-8 Modulates Innate and Adaptive Immune Response Genes in Bovine Neutrophils." Journal of Molecular Biology Research 9, no. 1 (2019): 24. http://dx.doi.org/10.5539/jmbr.v9n1p24.

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Galectins (Gals) are a family of animal lectins that bind &beta;-galactosides through a carbohydrate recognition domain. Galectin-8 is a tandem-repeat galectin, secreted intracellularly and extracellularly. It is associated with neutrophil migration and has been studied as a possible therapeutic to combat inflammation. The objective of this study was to evaluate the translational and the transcriptional effects of recombinant Galectin-8 (rGal-8) on cow neutrophils. Blood was collected aseptically from Holstein-Friesian cows (n=10) from the North Carolina A&amp;T State University Dairy

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15

Altieri, D. C., S. J. Stamnes, and C. G. Gahmberg. "Regulated Ca2+ signalling through leukocyte CD11b/CD18 integrin." Biochemical Journal 288, no. 2 (1992): 465–73. http://dx.doi.org/10.1042/bj2880465.

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General mechanisms of adhesion in the immune response are coordinated by the leukocyte integrins CD11/CD18. The possible participation of these differentiation molecules in early events of transmembrane signalling was investigated. Monoclonal antibody (mAb) cross-linking of CD18, the integrin beta subunit ubiquitously expressed by all leukocytes, increased the cytosolic free Ca2+ concentration ([Ca2+]i) by 2-3-fold in monocyte THP-1 cells. Digitalized imaging in single adherent cells showed that this Ca2+ response is temporally biphasic, involves both release of Ca2+ from the intracellular sto

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16

Vijayan, M., K. Saikrishnan, P. Kumar та ін. "Banana lectin, a β-prism I fold lectin with two carbohydrate-binding sites". Acta Crystallographica Section A Foundations of Crystallography 61, a1 (2005): c232. http://dx.doi.org/10.1107/s0108767305090094.

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17

Mahanta, S. K., M. V. K. Sastry, and A. Surolia. "Topography of the combining region of a Thomsen-Friedenreich-antigen-specific lectin jacalin (Artocarpus integrifolia agglutinin). A thermodynamic and circular-dichroism spectroscopic study." Biochemical Journal 265, no. 3 (1990): 831–40. http://dx.doi.org/10.1042/bj2650831.

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Thermodynamic analysis of carbohydrate binding by Artocarpus integrifolia (jackfruit) agglutinin (jacalin) shows that, among monosaccharides, Me alpha GalNAc (methyl-alpha-N-acetylgalactosamine) is the strongest binding ligand. Despite its strong affinity for Me alpha GalNAc and Me alpha Gal, the lectin binds very poorly when Gal and GalNAc are in alpha-linkage with other sugars such as in A- and B-blood-group trisaccharides, Gal alpha 1-3Gal and Gal alpha 1-4Gal. These binding properties are explained by considering the thermodynamic parameters in conjunction with the minimum energy conformat

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18

Sabotič та Kos. "CNL–Clitocybe nebularis Lectin—The Fungal GalNAcβ1-4GlcNAc-Binding Lectin". Molecules 24, № 23 (2019): 4204. http://dx.doi.org/10.3390/molecules24234204.

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Clitocybe nebularis lectin (CNL) is present in fruiting bodies of clouded agaric along with several similar isolectins that are all small and stable proteins. It is a beta-trefoil type lectin forming homodimers that are essential for its functionality. It binds specifically N,N’-diacetyllactosediamine (GalNAcβ1-4GlcNAc, LacDiNac) and human blood group A determinant-containing glycan epitopes. Its most probable function is to defend fruiting bodies against predators and parasites. In addition, an endogenous regulatory function is possible for CNL, as indicated by its interaction with fungal pro

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19

Dardevet, D., K. Komori, C. Grunfeld, S. A. Rosenzweig, and M. G. Buse. "Increased hepatic insulin proreceptor-to-receptor ratio in diabetes: a possible processing defect." American Journal of Physiology-Endocrinology and Metabolism 261, no. 5 (1991): E562—E571. http://dx.doi.org/10.1152/ajpendo.1991.261.5.e562.

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Hepatic insulin proreceptors and receptors were studied in control and in ketotic diabetic rats 2-4 wk after streptozotocin treatment. Solubilized preparations were partially purified by wheat germ agglutinin-agarose (WGA) and lentil lectin agarose (LLA) chromatography to enrich eluates in insulin receptors and proreceptors, respectively. After phosphorylation with [gamma-32P]ATP, an approximately 190-kDa glycoprotein was identified in LLA eluates as the insulin proreceptor, based on insulin dose-dependent tyrosine autophosphorylation, immunoprecipitation with insulin receptor-specific antibod

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20

Sankaranarayanan, Rajan, Kanakaraj Sekar, Rahul Banerjee, Vivek Sharma, Avadhesha Surolia та Mamannamana Vijayan. "A novel mode of carbohydrate recognition in jacalin, a Moraceae plant lectin with a β-prism fold". Nature Structural Biology 3, № 7 (1996): 596–603. http://dx.doi.org/10.1038/nsb0796-596.

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21

Vijayan, M., K. Sekar, R. Banerjee, S. K. Mahanta, A. Surolia та R. Sankaranarayanan. "A threefold symmetric β-prism fold without internal sequence homology in the structure of the two-chain lectin jacalin". Acta Crystallographica Section A Foundations of Crystallography 52, a1 (1996): C174. http://dx.doi.org/10.1107/s0108767396092306.

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22

Bourne, Yves, Véronique Roig-Zamboni, Annick Barre та ін. "The Crystal Structure of theCalystegia sepiumAgglutinin Reveals a Novel Quaternary Arrangement of Lectin Subunits with a β-Prism Fold". Journal of Biological Chemistry 279, № 1 (2003): 527–33. http://dx.doi.org/10.1074/jbc.m308218200.

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23

Kaplanski, G., C. Farnarier, S. Kaplanski, et al. "Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism." Blood 84, no. 12 (1994): 4242–48. http://dx.doi.org/10.1182/blood.v84.12.4242.bloodjournal84124242.

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Inflammation is characterized by migration of neutrophils through the endothelium, and the chemokine interleukin-8 (IL-8) appears to be involved. We asked whether adherence of cells bearing a membrane-form of interleukin 1 (IL-1) induces IL-8 secretion from human umbilical vein endothelial cells (HUVEC) and fibroblasts. Human peripheral blood mononuclear cells (PBMC) were stimulated with endotoxin for 12 hours and then fixed for 4 hours with paraformaldehyde. When these cells were added to HUVEC or fibroblasts, IL-8 production was induced. This stimulation by fixed PBMC was attributed to IL-1,

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24

Powell, L. D., S. W. Whiteheart, and G. W. Hart. "Cell surface sialic acid influences tumor cell recognition in the mixed lymphocyte reaction." Journal of Immunology 139, no. 1 (1987): 262–70. http://dx.doi.org/10.4049/jimmunol.139.1.262.

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Abstract The Ia+ B cell lymphoma, AKTB-1b, fails to stimulate thymic lymphocytes in a one-way mixed lymphocyte reaction unless pretreated with sialidase or inhibitors of N-linked oligosaccharide processing. A comparison of different sialidases and sialyltransferases suggests that the removal of only a subset of total surface sialic acid, rather than net desialylation of the cell surface, is required. Three sialidases were compared, including Vibrio cholerae (VC) and Clostridium perfringens (CP), which will cleave alpha 2-3, alpha 2-6, and alpha 2-8, sialic acid linkages, and Newcastle Disease

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25

Ford, Bradley, Denis Verger, Karen Dodson, et al. "The Structure of the PapD-PapGII Pilin Complex Reveals an Open and Flexible P5 Pocket." Journal of Bacteriology 194, no. 23 (2012): 6390–97. http://dx.doi.org/10.1128/jb.06651-11.

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ABSTRACTP pili are hairlike polymeric structures that mediate binding of uropathogenicEscherichia colito the surface of the kidney via the PapG adhesin at their tips. PapG is composed of two domains: a lectin domain at the tip of the pilus followed by a pilin domain that comprises the initial polymerizing subunit of the 1,000-plus-subunit heteropolymeric pilus fiber. Prior to assembly, periplasmic pilin domains bind to a chaperone, PapD. PapD mediates donor strand complementation, in which a beta strand of PapD temporarily completes the pilin domain's fold, preventing premature, nonproductive

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26

Rosa, José César, Lewis Joel Greene, Paulo SÉRgio Lopes De Oliveira та ін. "KM+, a mannose-binding lectin from artocarpus integrifolia: Amino acid sequence, predicted tertiary structure, carbohydrate recognition, and analysis of the β-prism fold". Protein Science 8, № 1 (2008): 13–24. http://dx.doi.org/10.1110/ps.8.1.13.

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27

Ledoux, S., N. Rebai, A. Dagenais, et al. "Amyloid precursor protein in peripheral mononuclear cells is up-regulated with cell activation." Journal of Immunology 150, no. 12 (1993): 5566–75. http://dx.doi.org/10.4049/jimmunol.150.12.5566.

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Abstract The deposition of beta/A4 protein in extraneural organs of patients with Alzheimer disease suggests that this peptide may in part be derived from a peripheral precursor. We studied expression of amyloid precursor protein (APP) in PBMC. APP expression was detectable in resting PBMC by northern blot analysis, immunoblotting studies, and immunohistochemistry. By reverse transcription-polymerase chain reaction, the 751 and 770 APP transcripts containing the Kunitz protease inhibitor (KPI) domain were approximately 10-fold more abundant than the 695 transcript lacking the KPI domain. Activ

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28

Dutta, Somnath, Budhaditya Mazumdar, Kalyan K. Banerjee, and Amar N. Ghosh. "Three-Dimensional Structure of Different Functional Forms of the Vibrio cholerae Hemolysin Oligomer: a Cryo-Electron Microscopic Study." Journal of Bacteriology 192, no. 1 (2009): 169–78. http://dx.doi.org/10.1128/jb.00930-09.

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ABSTRACT Vibrio cholerae hemolysin (HlyA) is a 65-kDa water-soluble pore-forming toxin that causes lysis of eukaryotic cells by destroying selective permeability of the plasma membrane bilayer. The HlyA monomer self-assembles on the target cell surface to the more stable β-barrel amphipathic heptamer, which inserts into the membrane bilayer to form a diffusion channel. Deletion of the 15-kDa β-prism lectin domain at the C terminus generates a 50-kDa hemolysin variant (HlyA50) with an ∼1,000-fold decrease in hemolytic activity. Because functional differences are eventually dictated by structura

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29

Hirai, K., A. L. De Weck, and B. M. Stadler. "Characterization of a human basophil-like cell promoting activity." Journal of Immunology 140, no. 1 (1988): 221–27. http://dx.doi.org/10.4049/jimmunol.140.1.221.

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Abstract Biologic and biochemical properties of a human basophil-like cell promoting activity (BaPA), which induces growth of metachromatically staining cells from normal bone marrow cells in a liquid culture system have been examined. In order to study this T cell factor, an assay was developed based on the intracellular histamine content of the cultured human bone marrow cells. Many lymphokines, including granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor, interleukin 1 alpha and 1 beta, interleukin 2, and interferon-alpha and gamma, did not exhibit any s

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30

Issad, T., J. M. Tavaré, and R. M. Denton. "Analysis of insulin receptor phosphorylation sites in intact rat liver cells by two-dimensional phosphopeptide mapping. Predominance of the tris-phosphorylated form of the kinase domain after stimulation by insulin." Biochemical Journal 275, no. 1 (1991): 15–21. http://dx.doi.org/10.1042/bj2750015.

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1. Insulin receptors were partially purified from rat liver by chromatography on wheat-germ-lectin-Sepharose. Incubation with [gamma-32P]ATP in the presence of insulin resulted in increased phosphorylation of the beta-subunit on both tyrosine and serine residues. Two-dimensional mapping of tryptic peptides showed that, in agreement with previous studies using preparations of receptors from other sources, the tyrosine residues involved were the three tyrosines in the kinase domain (corresponding to tyrosines 1158, 1162 and 1163 of the human receptor) plus two tyrosines close to the C-terminus (

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31

Gong, Z. Y., and B. Brandhorst. "Autogenous regulation of tubulin synthesis via RNA stability during sea urchin embryogenesis." Development 102, no. 1 (1988): 31–43. http://dx.doi.org/10.1242/dev.102.1.31.

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When pluteus embryos of Lytechinus pictus were treated with colcemid, the incorporation of [35S]methionine into tubulin declined by 5- to 15-fold within 4 h. This was mostly accounted for by a rapid decline in the concentration of alpha- and beta-tubulin mRNA in the cytoplasm. Treatment with other microtubule depolymerizing agents (colchicine, nocodazole, low concentrations of vinblastine) had similar effects. Treatment of embryos with the microtubule-stabilizing agent, taxol, or high concentrations of vinblastine resulted in increased synthesis of tubulin. The concentration of tubulin mRNA in

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32

Ruffet, E., N. Paquet, S. Frutiger, G. J. Hughes, and J. C. Jaton. "Structural and electron-microscopic studies of jacalin from jackfruit (Artocarpus integrifolia) show that this lectin is a 65 kDa tetramer." Biochemical Journal 286, no. 1 (1992): 131–34. http://dx.doi.org/10.1042/bj2860131.

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The 133-amino-acid sequences of the alpha-subunit of jacalin (a lectin from Artocarpus integrifolia) and of the slightly larger alpha'-subunit were determined. The alpha'- and alpha-subunits, in the approximate ratio of 1:3, were found to be virtually identical in their primary structures, except for one valine for isoleucine substitution at position 113. Although both alpha'- and alpha-chains were glycosylated, the extent of glycosylation in the alpha'-chain was much greater than that in the alpha-subunit. In the alpha'-polypeptide, all molecules contained an N-linked oligosaccharide at posit

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33

Uriarte, M., W. Stalmans, S. Hickman, and M. Bollen. "Phosphorylation and nucleotide-dependent dephosphorylation of hepatic polypeptides related to the plasma cell differentiation antigen PC-1." Biochemical Journal 293, no. 1 (1993): 93–100. http://dx.doi.org/10.1042/bj2930093.

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A glycoprotein fraction was isolated from rat liver membranes by affinity chromatography on immobilized wheat-germ lectin. Incubation of this fraction with MgATP or MgGTP resulted in a sequential phosphorylation and dephosphorylation of a complex of three polypeptides (118, 128 and 197 kDa on SDS/PAGE) with N-linked sialyloligosaccharides. Each polypeptide was recognized by polyclonal antibodies against recombinant plasma cell differentiation antigen PC-1. The relationship of the 118 kDa and 128 kDa polypeptides with PC-1 was confirmed by observations that they are linked by disulphide bonds i

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34

Nyholm Kyvsgaard, Julie, Christina Ellervik, Emilie Bundgaard Lindkvist, et al. "Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins." Nutrients 11, no. 9 (2019): 1980. http://dx.doi.org/10.3390/nu11091980.

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(1) Background: Zinc is an essential micronutrient and zinc deficiency is associated with immune dysfunction. The neonatal immune system is immature, and therefore an optimal neonatal zinc status may be important. The aim of this study was to investigate the possible association between neonatal whole blood (WB)-Zinc content and several immune markers. (2) Methods: In total, 398 healthy newborns (199 who later developed type 1 diabetes and 199 controls) from the Danish Newborn Screening Biobank had neonatal dried blood spots (NDBS) analyzed for WB-Zinc content and (i) cytokines: Interleukin (I

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35

Ashur-Fabian, Osnat, Adi Har-Zahav, Aviv Shaish, et al. "Imatinib Mesylate Affects the Expression of Lipid Metabolism Genes in K562, a Chronic Myeloid Leukemia Cell Line." Blood 112, no. 11 (2008): 4238. http://dx.doi.org/10.1182/blood.v112.11.4238.4238.

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Abstract Background: Imatinib mesylate (IM) is a tyrosine kinase inhibitor designed to inhibit the BCR-ABL fusion protein, the hallmark of chronic myeloid leukemia (CML). Interestingly, IM treatment possesses a rapid lipid-lowering effect on patients with hyperlipidemia, particularly those receiving 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCoAR) inhibitors. While it is known that IM may competitively inhibit statin metabolism, the lipid-lowering effect of IM is not fully understood. Therefore, we have studied the effects of IM on a family of genes critically involved in lipid metabolism,

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36

Wallgren, A., R. Festin, C. Gidlof, M. Dohlsten, T. Kalland, and TH Totterman. "Efficient killing of chronic B-lymphocytic leukemia cells by superantigen-directed T cells." Blood 82, no. 4 (1993): 1230–38. http://dx.doi.org/10.1182/blood.v82.4.1230.1230.

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Abstract In vitro studies have indicated that chronic lymphocytic leukemia of B- cell origin (B-CLL) is resistant to cytotoxic effector lymphocytes such as natural killer and lymphokine activated killer (LAK) cells. We show here that B-cell cells are sensitive to Staphylococcal enterotoxin (SE) A-directed T-cell killing. Activation of the target cells by phorbol ester (tetradecanoyl phorbol acetate, [TPA]) greatly enhances their sensitivity to lysis. In SE-dependent cellular cytotoxicity (SDCC), members of the SE superantigen family form a bridge between T cells and target cells expressing maj

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37

Wallgren, A., R. Festin, C. Gidlof, M. Dohlsten, T. Kalland, and TH Totterman. "Efficient killing of chronic B-lymphocytic leukemia cells by superantigen-directed T cells." Blood 82, no. 4 (1993): 1230–38. http://dx.doi.org/10.1182/blood.v82.4.1230.bloodjournal8241230.

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In vitro studies have indicated that chronic lymphocytic leukemia of B- cell origin (B-CLL) is resistant to cytotoxic effector lymphocytes such as natural killer and lymphokine activated killer (LAK) cells. We show here that B-cell cells are sensitive to Staphylococcal enterotoxin (SE) A-directed T-cell killing. Activation of the target cells by phorbol ester (tetradecanoyl phorbol acetate, [TPA]) greatly enhances their sensitivity to lysis. In SE-dependent cellular cytotoxicity (SDCC), members of the SE superantigen family form a bridge between T cells and target cells expressing major histoc

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38

Altieri, D. C., and T. S. Edgington. "Identification of effector cell protease receptor-1. A leukocyte-distributed receptor for the serine protease factor Xa." Journal of Immunology 145, no. 1 (1990): 246–53. http://dx.doi.org/10.4049/jimmunol.145.1.246.

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Abstract Mitogenesis, cell differentiation and immune-inflammatory responses are regulated by the coordinated assembly of proteases with specific cellular receptors. We have investigated the possibility that immune effector cells may express a high-affinity protease receptor. To address this hypothesis, we have generated mAb to factor V and its activated form Va, a circulating plasma protein that binds the serine protease of the coagulation cascade, factor Xa. Further, by flow microfluorimetry screening, we have isolated a panel of these mAb that recognize a surface molecule expressed on trans

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Desai, Ankit A., Tong Zhou, Mehdi Nouraie, Victor R. Gordeuk, Joe GN Garcia, and Roberto F. Machado. "Genomic Assessment of Mortality in Sickle Cell Disease- A Novel Association with Cytokine Imbalance and T Cell Dysregulation." Blood 118, no. 21 (2011): 1081. http://dx.doi.org/10.1182/blood.v118.21.1081.1081.

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Abstract Abstract 1081 Rationale: Sickle cell disease (SCD) is characterized by systemic complications and significant clinical variability. While some patients never experience severe clinical events, others suffer lifelong morbidity and accelerated mortality. To address this variability, we prospectively followed patients with SCD at steady-state to assess outcomes and leveraged microarray analysis of RNA isolated from peripheral blood mononuclear cells (PBMCs) to identify novel gene expression patterns and signaling pathways that could be associated with survival in SCD. Methods: Forty-two

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Mulakala, Bharath Kumar, Eluka-Okoludoh Eboghoye, Kingsley Ekwemalor, and Mulumebet Worku. "PSIX-20 Galectins expression and secretion in cow milk." Journal of Animal Science 99, Supplement_3 (2021): 266–67. http://dx.doi.org/10.1093/jas/skab235.488.

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Abstract The objective of this study was to assess the expression and secretion of Galectins (Gal) in cow milk. Cow milk contains a range of proteins of moderate or low abundance that contribute to host defense. However, host defense proteins in milk were not fully discovered. Galectins belong to the lectin family that recognizes specific carbohydrates on cells and involved in innate immune responses. Holstein Friesian cows (n = 16) from North Carolina A&T diary unit were used for this study. Based on the Dairy Heard farm index, eight cows each were assigned to the high or low SCC group. T

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Jung, Jinwon, Juhee Kim, Bora Lee, et al. "Abstract 6296: Preclinical study of a novel anti-CLEC12A antibody-drug conjugate with a glucuronide-protected pyrrolobenzodiazepine payload." Cancer Research 83, no. 7_Supplement (2023): 6296. http://dx.doi.org/10.1158/1538-7445.am2023-6296.

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Abstract C-type lectin domain family 12 member A (CLEC12A, CLL-1) is a single-pass transmembrane protein of 265 amino acids that is found on monocytes and AML blasts. We have created and characterized antibody-drug conjugates (ADCs) based on a humanized CLEC12A specific antibody to determine whether CLEC12A may be exploited as a therapeutic target for AML. The payload is a proprietary PBD prodrug with a beta-glucuronide trigger, and the linker-payload was conjugated through farnesyltransferase-mediated functionalization. The ADC demonstrated sub-nM cytotoxicity in vitro against several CLEC12A

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Vennegoor, C. J., E. van de Wiel-van Kemenade, R. J. Huijbens, F. Sanchez-Madrid, C. J. Melief, and C. G. Figdor. "Role of LFA-1 and VLA-4 in the adhesion of cloned normal and LFA-1 (CD11/CD18)-deficient T cells to cultured endothelial cells. Indication for a new adhesion pathway." Journal of Immunology 148, no. 4 (1992): 1093–101. http://dx.doi.org/10.4049/jimmunol.148.4.1093.

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Abstract Patients with the leukocyte adhesion deficiency (LAD) syndrome have a genetic defect in the common beta 2-chain (CD18) of the leukocyte integrins. This defect can result in the absence of cell surface expression of all three members of the leukocyte integrins. We investigated the capacity of T cell clones obtained from the blood of an LAD patient and of normal T cell clones to adhere to human umbilical vein endothelial cells (EC). Adhesion of the number of LAD T cells to unstimulated EC was approximately half of that of leukocyte function-associated antigen (LFA)-1+ T cells. Stimulati

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Chorich, Lynn P., Michael P. Diamond, Janet E. Hall, et al. "OR06-3 ESR1 Pathogenic Variant With Incomplete Estrogen Insensitivity." Journal of the Endocrine Society 6, Supplement_1 (2022): A677—A678. http://dx.doi.org/10.1210/jendso/bvac150.1401.

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Abstract Introduction Estrogen is vital to human reproduction and acts primarily through two receptors: estrogen receptor alpha (ERα, encoded by ESR1) and estrogen receptor beta (ERβ, encoded by ESR2). Surprisingly, very few human ESR1 pathogenic variants have been recognized, despite the existence of &gt;1000 different androgen receptor pathogenic variants causing androgen insensitivity syndrome. Functional analysis of an ESR1 homozygous missense variant (p.Glu375His) in the ERα ligand-binding domain (LBD) showed a 240-fold decrease in estrogen response in a patient with complete estrogen

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Sivaji, Nukathoti, Kaza Suguna, Avadhesha Surolia, and Mamannamana Vijayan. "Structural and related studies on Mevo lectin from Methanococcus voltae A3: the first thorough characterization of an archeal lectin and its interactions." Glycobiology, July 11, 2020. http://dx.doi.org/10.1093/glycob/cwaa063.

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Abstract Crystallographic and solution studies of Mevo lectin and its complexes, the first effort of its kind on an archeal lectin, reveal a structure similar to β-prism I fold lectins from plant and animal sources, but with a quaternary association involving a ring structure with seven-fold symmetry. Each subunit in the heptamer carries one sugar binding site on the first Greek key motif. The oligomeric interface is primarily made up of a parallel β-sheet involving a strand of Greek key I of one subunit and Greek key ΙΙΙ from a neighboring subunit. The crystal structures of the complexes of t

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Moore, Jordan T., Mohamed Ewees, Jay L. Zweier, Daniel Gallego-perez, and Yousef Hannawi. "Abstract P54: Endothelial Cells and Pericytes Collection Using Laser Capture Microdissection in Spontaneously Hypertensive Stroke Prone Rats." Stroke 52, Suppl_1 (2021). http://dx.doi.org/10.1161/str.52.suppl_1.p54.

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Introduction: Neurovascular unit (NVU) dysfunction plays a key role in cerebral small vessel disease (cSVD) pathogenesis. Spontaneously Hypertensive Rats - Stroke Prone (SHRSP) is a relevant model for cSVD where prominent impairment of the NVU has been identified. Previous studies of SHRSP and Wistar-Kyoto control rats (WKY) were performed at tissue level failing to capture the NVU cellular components where the early pathological events occur. Therefore, we developed a novel method for selective endothelial cell (EC) and pericytes capture using Laser Capture Microdissection (LCM). Methods: 10

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AHAMAD, ADIL, and S. H. ANSARI. "A REVIEW ON MULTIPURPOSE MEDICINAL PROPERTIES OF TRADITIONALLY USED PSIDIUM GUAJAVA LEAVES." Asian Journal of Pharmaceutical and Clinical Research, August 7, 2022, 9–22. http://dx.doi.org/10.22159/ajpcr.2022.v15i8.43179.

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Psidium guajava is an important food crop and medicinal plant available in tropical and subtropical countries. P. guajava (Guava), belonging to the family of Myrtaceae. P. guajava Linn. (Guava) is used not only as food but also as folk medicine in subtropical areas around the world because of its pharmacologic activities. It contains important phytoconstituents such as tannins, triterpenes, flavonoid, quercetin, pentacyclic triterpenoid, guajanoic acid, saponins, carotenoids, lectins, leucocyanidin, ellagic acid, amritoside, beta-sitosterol, uvaol, oleanolic acid, and ursolic acid. Conventiona

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Azimudin, Ridha, S. Preetha, J. Selvaraj, Sridevi G, and Jeevitha M. "Effect of Carica Seed Extract on Inhibitory Kappa B Kinase Beta and mTOR mRNA Expression in Lung Cancer Cells (A549 Cells)." Journal of Pharmaceutical Research International, January 27, 2022, 10–17. http://dx.doi.org/10.9734/jpri/2022/v34i5b35410.

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Background: Lung cancer is considered as one of the most common causes for cancer-related death globally. Carica papaya is one of the most well-known traditional medicines to treat diseases, and is also known to treat cancer and help in cancer prevention. The study investigates the effect of Carica seed extract on inhibitory kappa B kinase beta and mTOR mRNA expression in lung cancer cells (A549 cells). Methods: Cell viability test was assessed using MTT assay. mRNA expression of inhibitory kappa B kinase beta and mTOR mRNA was analyzed by real-time PCR. The results was analysed statisti

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"$beta;-galactoside-binding lectins in hearts and cardiac myocytes of adult rats and rabbits C. K�nig and G. Gercken. Institute of Biochemistry and Food Chemistry, University of Hamburg, 2000 Hamburg 13, F.R.G." Journal of Molecular and Cellular Cardiology 21 (July 1989): S28. http://dx.doi.org/10.1016/0022-2828(89)91297-2.

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Iribarren, Carlos, Malini Chandra, Mark A. Hlatky, Stephen Fortmann, Thomas Quertermous, and Alan S. Go. "Abstract P016: Galectin-3 and Incident Heart Failure among Patients with Pre-existing Coronary Artery Disease: the ADVANCE Study." Circulation 129, suppl_1 (2014). http://dx.doi.org/10.1161/circ.129.suppl_1.p016.

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Galecin-3 (Gal-3) is a novel beta-galactoside-binding lectin implicated in pro-fibrotic pathways that are upregulated during cardiac remodeling. Gal-3 has been associated with poor prognosis among patients with heart failure and with development of heart failure after acute coronary syndrome. In this study we sought to ascertain: 1) the cross-sectional demographic, behavioral and clinical correlates of serum levels of Gal-3, and 2) its independent predictive value for incident heart failure among 1,312 participants in The Atherosclerotic Disease, VAscular FunctioN and GenetiC Epidemiology (ADV

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Ali Sheikh, M. S., A. Alduraywish, A. Almaeen, et al. "The clinical impact of serum sLOX-1 level in coronary artery disease patients as inferred from its implication in the in vitro protective effects of metoprolol against hypoxic injury of HUVECs." European Heart Journal 41, Supplement_2 (2020). http://dx.doi.org/10.1093/ehjci/ehaa946.1388.

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Abstract Background Ischemic coronary artery disease (CAD) is a major public health problem across the world. Early detection and appropriate management significantly reduced CAD-induced morbidities and death. Endothelial cells are pathogenically implicated. Purpose Our study was designed to investigate the role of the soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) in the in vitro protective effect of Metoprolol against hypoxia-induced injury of Human umbilical vein endothelial cells (HUVECs). Secondly, the clinical significance of variations in serum levels of sLOX-1

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