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Journal articles on the topic 'Betadine'

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Published: 4 June 2021
Last updated: 15 June 2025

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1

Kim, J. H., J. Rimmer, N. Mrad, S. Ahmadzada, and R. J. Harvey. "Betadine has a ciliotoxic effect on ciliated human respiratory cells." Journal of Laryngology & Otology 129, S1 (2014): S45—S50. http://dx.doi.org/10.1017/s0022215114002746.

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AbstractObjective:This study investigated the effect of Betadine on ciliated human respiratory epithelial cells.Methods:Epithelial cells from human sinonasal mucosa were cultured at the air–liquid interface. The cultures were tested with Hanks' balanced salt solution containing 10 mM HEPES (control), 100 µM ATP (positive control), 5 per cent Betadine or 10 per cent Betadine (clinical dose). Ciliary beat frequency was analysed using a high-speed camera on a computer imaging system.Results:Undiluted 10 per cent Betadine (n = 6) decreased the proportion of actively beating cilia over 1 minute (p < 0.01). Ciliary beat frequency decreased from 11.15 ± 4.64 Hz to no detectable activity. The result was similar with 5 per cent Betadine (n = 7), with no significant difference compared with the 10 per cent solution findings.Conclusion:Betadine, at either 5 and 10 per cent, was ciliotoxic. Caution should be applied to the use of topical Betadine solution on the respiratory mucosal surface.
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2

Ageeva, Elena Vladimirovna, Anna Evgen'yevna Grodnenskaya, and Kseniya Aleksandrovna Popova. "The role of preventive topical antibiotic treatment prior to intravitreal injection." Ophthalmology journal 8, no. 2 (2015): 79–83. http://dx.doi.org/10.17816/ov2015279-83.

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Treatment of wet age-related macular degeneration (AMD) requires frequent intravitreal injections of anti-VEGF agents, sometimes on monthly basis during a long period of time. Endophthalmitis is a rare but extremely severe complication of intravitreal injections. As it has been proven before, the flora from the conjunctival surface is the main source for endophthalmitis. Using Povidone-iodine solution (Betadine10 % Povidone-iodine, EGIS PHARMACEUTICALS) is the only way to prevent endophthalmitis. The efficacy of it was proven by numerous studies. No evidence exists that topical antibiotiotics prior and after injections could be effective for prevention of endophthalmitis. Purpose: To study the advisability of topical antibiotic application before intravitreal injection. Materials and methods: Under investigation, there were 25 eyes of 25 patients with wet AMD treated by anti-VEGF intravitreal injections. All patients used topical antibiotics 3 days before injection. Conjunctival culture from injection eye was collected three times: before topical antibiotic use; after topical antibiotic use, and after Betadine 5 % application. Results: The rates of Staphylococcus epidermidis before and after topical antibiotic use were approximately equal. However there was no Staphylococcus epidermidis found after Betadine 5 % application. Conclusion: Our study showed the effectiveness of Betadine 5 % solution in conjunctival flora reduction. Use of topical antibiotics 3 days prior intravitreal injections is not effective. Key words: age-related macular degeneration; endophthalmitis; intravitreal injection; topical antibiotics; endophthalmitis prevention.
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3

Liana, Yunita, and Yofa Anggriani Utama. "Efektifitas pemberian ekstrak daun betadine (jatropha muitifida linn) terhadap ketebalan jaringan granulasi dan jarak tepi luka pada penyembuhan luka sayat tikus putih (rattus norvegicus)." Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya 5, no. 3 (2018): 114–23. http://dx.doi.org/10.32539/jkk.v5i3.6313.

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Luka adalah hilang atau rusaknya sebagian jaringan tubuh. Proses penyembuhan tidak hanya terbatas pada proses regenerasi yang bersifat lokal, tetapi juga sangat dipengaruhi oleh oleh banyak faktor, salah satunya adalah jenis obat-obatan. Penyembuhan luka adalah suatu bentuk proses usaha untuk memperbaiki kerusakan yang terjadi pada kulit. Salah satu tanaman yang berpotensi terhadap penyembuhan luka adalah tanaman betadine. Tujuan dari penelitian ini adalah untuk mengetahui efektifitas pemberian ekstrak daun betadine terhadap ketebalan jaringan granulasi dan jarak tepi luka sayat tikus putih (Rattus norvegicus). Desain penelitian studi eksperimental dengan menggunakan rancangan penelitian post test only control group design. Penelitian ini dilakukan di Laboratorium Biomedik Fakultas Teknik Kimia Politeknik Sriwijaya Palembang untuk pelaksanaan ekstraksi dan pembuatan salep ekstrak daun betadine, di Animal House Fakultas Kedokteran Unsri Palembang untuk pemeliharaan dan perlakuan pada tikus putih dan Laboratorium Patologi RSUP dr. Mohammad Hoesin Palembang untuk pemeriksaan jaringan kulit tikus putih. Jumlah sampel 30 tikus putih. Analisis statistik uji homogenitas antar kelompok dengan menggunakan levene test, Independent t-test, Uji One Way Anova untuk mengetahui jaringan granulasi dan jarak tepi luka dilanjutkan dengan uji post hoc multiple comparisons t-test games howel. Hasil uji statistik salep ekstrak daun betadine mempunyai efek yang sama dengan salep madecassol terhadap ketebalan jaringan granulasi dan jarak tepi luka pada luka sayat tikus putih. Dosis yang paling efektif adalah pada dosis 40% salep ekstrak daun betadine. Diharapkan perlu penelitian lanjutan tentang efek daun betadine terhadap protein-protein pada saat proses inflamasi toksisitas dari daun betadine.
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4

Rusdy, Hendry, Astri Suryani Pasaribu Saruksuk, Rahmi Syaflida Dalimunte, and Gostry Aldica Dohude. "Efektivitas getah batang betadine (Jatropha multifida L.) terhadap penyembuhan luka pasca pencabutan gigi pada tikus Sprague-DawleyEffectiveness of betadine (Jatropha multifida L.) stem sap on the wound healing after tooth extraction in Sprague-Dawley rats." Jurnal Kedokteran Gigi Universitas Padjadjaran 33, no. 2 (2021): 145. http://dx.doi.org/10.24198/jkg.v33i2.32563.

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Pendahuluan: Pencabutan gigi merupakan prosedur yang sering dilakukan di kedokteran gigi. Setelah pencabutan gigi akan dihasilkan suatu perlukaan. Proses penyembuhan luka dapat dipercepat pada kondisi tertentu. Salah satu bahan alami yang dapat membantu proses penyembuhan luka adalah getah tanaman betadine (Jatropha multifida L.). Penelitian bertujuan untuk menganalisis efektivitas getah tanaman betadine terhadap penyembuhan luka dan terhadap tanda-tanda infeksi pasca pencabutan gigi Metode: Desain penelitian studi eksperimental laboratorium dengan rancangan penelitian post-test only control group design menggunakan 30 ekor tikus Sprague-Dawley. Teknik pengambilan sampel yaitu convenience sampling. Sampel dibagi menjadi 2 kelompok yaitu kelompok perlakuan dan kelompok kontrol. Kelompok perlakuan diberikan getah tanaman betadine dan kelompok kontrol diberikan asam traneksamat secara oral menggunakan sonde lambung. Tunggu selama 4 jam setelah pemberian getah tanaman betadine dan asam traneksamat. Anestesi pada tikus menggunakan ketamin 50 mg/kg berat badan secara intramuskular kemudian dilakukan pencabutan pada gigi tikus. Pengamatan dilakukan dengan melihat kriteria klinis pada hari 1,3,7 dan diperhatikan sampai luka sembuh serta lihat tanda-tanda infeksi. Analisis data dilakukan dengan uji normalitasShapiro Wilik. Hasil penelitian menunjukkan bahwa data berdistribusi tidak normal. Analisis data dilanjutkan menggunakan uji statistik mann whitney. Hasil: Terdapat perbedaan signifikan penyembuhan luka soket pasca pencabutan gigi setelah diberikan getah betadine dan asam traneksamat dengan nilai p=0,037 (p<0,005). Simpulan: Pemberian getah tanaman betadine terbukti lebih efektif terhadap proses penyembuhan luka soket pasca pencabutan gigi dibandingkan dengan pemberian asam traneksamat. Kata kunci: tikus Sprague-Dawley; penyembuhan luka; pencabutan gigi; getah batang betadine ABSTRACTIntroduction: Tooth extraction is a procedure often performed in dentistry. Tooth extraction will always cause injuries. However, the wound healing process can be accelerated under certain conditions. One of the natural ingredients that can accelerate the wound healing process is betadine (Jatropha multifida L.) plant sap. The study was aimed to analyzed the effect of betadine plant sap on wound healing and signs of infection after tooth extraction. Methods: Experimental laboratory study design with post-test only control group design was conducted towards 30 Sprague-Dawley rats. The sampling technique was convenience sampling. The sample was divided into two groups, the treatment group and the control group. The treatment group was administered with betadine plant sap, and the control group was administered with tranexamic acid orally using a gastric probe, then waited 4 hours after. The anaesthesia was then performed using 50 mg/kg body weight of ketamine intramuscularly. The extraction was performed after. Observations was conducted at the clinical criteria on days 1, 3, and 7 and continue to be monitored until the wound heals. Then, the signs of infection were observed. Data analysis was carried out using the Shapiro Wilk normality test. The results showed that the data was not normally distributed. Thus, data analysis was continued using the Mann Whitney statistical test. Results: The results showed a significant difference in the healing of socket wounds after tooth extraction after being administered with betadine sap and tranexamic acid with a value of p=0.037 (p<0.005). Conclusions: Administration of betadine plant sap is proven to be more effective in accelerating the healing process of socket wounds after tooth extraction than tranexamic acid. Keywords: Sprague-Dawley rats; wound healing; pencabutan gigi; getah batang betadine
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5

Nagle, Alyssa, Jonathan Kopel, John Reed, et al. "An in vitro Study of Betadine’s Ability to Eliminate Live Bacteria on the Eye: Should It Be Used for Protection against Endophthalmitis?" Antibiotics 11, no. 11 (2022): 1549. http://dx.doi.org/10.3390/antibiotics11111549.

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Background: Povidone-iodide (Betadine) is an antiseptic that is applied topically and has many uses in the medical community, such as in wound care and pre- and post-operative surgical procedures. This study was done to measure the effectiveness of Betadine solutions in inhibiting the growth of Gram-negative and Gram-positive bacteria. Methods: The ability of 2.5 and 10% Betadine solutions to inhibit bacterial growth was measured against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Acinetobacter baumannii. We grew the bacteria independently and together to simulate a hospital environment. Results: All the bacteria showed zones of inhibition. However, discs were also tested for live bacteria using the colony-forming unit assay. Complete killing was only seen for S. aureus with the 10% Betadine solution. All other bacteria showed growth on the disc. Conclusions: This study showed several things. First, the zone of inhibition assay does not give an accurate assessment of antimicrobial properties when used alone and should be followed by a colony-forming unit assay. Second, 2.5% and 5% Betadine do not have effective antimicrobial properties against any of the bacteria tested, and 10% Betadine is only effective against S. aureus and not effective against the other bacteria tested.
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6

Birnabach, D. J., E. M. Kitain, O. Murray, D. J. Stein, and E. M. Sordillo. "BETADINE-SEPTIC OR ANTISEPTIC?" Anesthesiology 77, Supplement (1992): A1040. http://dx.doi.org/10.1097/00000542-199209001-01040.

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7

Wiener, Thomas C. "Betadine and Breast Implants." Aesthetic Surgery Journal 33, no. 4 (2013): 615–17. http://dx.doi.org/10.1177/1090820x13484036.

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8

Jewell, Mark L., and William P. Adams. "Betadine and Breast Implants." Aesthetic Surgery Journal 38, no. 6 (2018): 623–26. http://dx.doi.org/10.1093/asj/sjy044.

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9

Gills, James P. "Effective Concentration of Betadine." Journal of Cataract & Refractive Surgery 25, no. 5 (1999): 604. http://dx.doi.org/10.1016/s0886-3350(99)00053-x.

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10

Sudarma, Nyoman, Sri Idayani, Didik Setiawan, and Putu Oka Dharmawan. "PEMANFAATAN BETADINE SEBAGAI INDIKATOR UJI KLORIN PADA BERAS BERPEMUTIH." Bali Medika Jurnal 5, no. 2 (2018): 14–21. http://dx.doi.org/10.36376/bmj.v5i2.32.

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Klorin merupakan salah satu penggunaan Bahan Makanan Tambahan yang dilarang. Menurut Peraturan Menteri Kesehatan Republik Indonesia No.033/Menkes/Per/IX/2012, bahwa klorin tidak tercatat sebagai Bahan Tambahan Pangan (BTP) dalam kelompok pemutihan dan pematang tepung. Klorin digunakan sebagai pemutih beras yang dimaksudkan agar beras memiliki kualitas super dengan harga yang tinggi. Masyarakat akan kesulitan membedakan beras yang mengandung klorin atau tidak sehingga perlu dilakukan uji sederhana yang dapat dilakukan oleh masyarakat luas. Povidon iodine atau dikenal dengan betadine yang merupakan bahan antiseptik luka merupakan salah satu alternatif digunakan untuk identifikasi secara kualitatif kandungan klorin baik pada makanan maupun air. Tujuan dari penelitian ini adalah untuk mengetahui apakah betadine dapat digunakan sebagai alternatif untuk identifikasi klorin pada sampel beras bermerk maupun non merk. Hasil penelitian menunjukkan bahwa betadine dapat digunakan sebagai indikator identifikasi klorin pada sampel beras yang dijual di pasaran. Sepuluh sampel beras yang diidentifikasi dua diantaranya terindikasi positif mengandung pemutih klorin. Sampel beras positif mengandung klorin jika setelah penambahan dengan betadine menghasilkan warna putih keruh. Uji penegasan dilakukan dengan menambahkan larutan amilum dan KI 10% pada sampel beras dan menghasilkan warna biru kehitaman.
 
 Kata kunci : beras, pemutih, klor, betadine
 
 
 ABSTRACT
 Chlorine is one of the prohibited uses of Foodstuffs. According to the Regulation of the Minister of Health of the Republic of Indonesia No.033 / Menkes / Per / IX / 2012, that chlorine is not recorded as a Food Additives (BTP) in the bleaching and flour milling group. Chlorine is used as rice bleach which is intended to have a super quality rice at a high price. The community will find it difficult to distinguish whether or not rice contains chlorine or not, so a simple test can be carried out by the community. Povidon iodine, also known as betadine, which is an antiseptic wound, is one alternative used to qualitative identify chlorine content in food and water. The purpose of this study was to determine whether betadine can be used as an alternative for identification of chlorine in samples of branded and non-branded rice. The results showed that betadine could be used as an indicator of chlorine identification in rice samples sold in the market. Ten rice samples were identified, two of which were indicated to be positive for chlorine bleach. The rice sample is positive for chlorine if after adding it with betadine it produces a cloudy white color. The affirmation test was carried out by adding a solution of starch and 10% KI to the rice sample and producing a blackish blue color.
 Key words: rice, bleach, chlorine, betadine
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11

Rusdy, Hendry, and Diah HI Damanik. "Antibacterial activity of Betadine (Jatropha multifida L.) stem extract on Pseudomonas aeruginosa growth in vitro." F1000Research 11 (October 27, 2022): 1222. http://dx.doi.org/10.12688/f1000research.123777.1.

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Background: Today, people use plants to treat various types of diseases and improve human health. One of the medicinal plants is the Betadine plant (Jatropha multifida L.). Betadine plants have many functions, especially the sap, leaves, fruit and seeds. The compound contents in Betadine stem sap, which is efficacious as an antimicrobial, are saponins, tannins, flavonoids and labaditin. One of the bacteria that cause infection is Pseudomonas aeruginosa. These bacteria can cause opportunistic and nosocomial infections. Methods: This study was a true experimental laboratory with a post-test only control group design. This study used Betadine stem sap extract with concentrations of 25%, 50%, 75%, 100%, gentamicin cream 10% as positive control, and dimethyl sulfoxide (DMSO) solution as negative control. This study used the Kirby-Bauer diffusion method and the bacterium Pseudomonas aeruginosa was grown on nutrient agar media, then incubated for 24 hours and calculated using calipers. Research data were analyzed using one-way ANOVA test. Results: The highest inhibition zone was group 50% (12.725 ± 0.2500 mm) while the lowest inhibition zone was group 100% (8.675 ± 0.5620 mm). Conclusions: Betadine stem extract had antibacterial activity in inhibiting the growth of Pseudomonas aeruginosa bacteria, with the 50% concentration being the most effective in inhibiting the growth of Pseudomonas aeruginosa bacteria.
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Bathla, Sonia, Edward J. Nevins, Parisa L. Moori, and Dale Vimalachandran. "Which pen? A comparative study of surgical site markers." Journal of Perioperative Practice 28, no. 1-2 (2018): 21–26. http://dx.doi.org/10.1177/1750458917742049.

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A preoperative requirement is the correct and clear marking of a specific surgical site. We aimed to compare the ability of marker pens to withstand surgical preparation. Five volunteers with different Fitzpatrick skin types were marked with ten pens. Marked skin sites were prepared with chlorhexidine followed by chlorhexidine, betadine followed by chlorhexidine, and betadine followed by betadine. Each site was photographed in theatre. Two volunteers ranked the top three most visible marker pens from each photograph. The results showed that Sharpie® W10 black, Dual Tip (Purple Surgical), and Easimark modern regular tip (Leonhard Lang) were the best performers across all skin types. Red pen should be avoided with betadine skin preparation. The study concludes that the above named three markers are the best at withstanding surgical skin preparation. Different skin types require different colour ink for maximal clarity in marking. Biro and drywipe markers should never be used for surgical marking.
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13

Culbertson, Eric J., Christina Felder-Scott, Anand K. Deva, David E. Greenberg, and William P. Adams. "Optimizing Breast Pocket Irrigation: The Breast Implant–Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era." Aesthetic Surgery Journal 40, no. 6 (2019): 619–25. http://dx.doi.org/10.1093/asj/sjz246.

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Abstract Background Specific antimicrobial breast pocket irrigations have been proven over the past 20 years to reduce the incidence of capsular contracture by a factor of 10, and the emergence of breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) and its link to bacteria/technique has created renewed interest in different antimicrobial breast pocket preparation agents. Our previous studies have identified that both Betadine-containing and non-Betadine-containing antimicrobial irrigations provide excellent broad-spectrum bacterial coverage. The current science of BIA-ALCL has implicated the Gram-negative microbiome as a key in pathogenesis. Objectives The aim of this study was to revisit the antimicrobial effectiveness of clinically utilized Betadine and non-Betadine solutions, along with other antimicrobial agents that have not yet been tested, against multiple organisms, including additional common Gram-negative bacteria associated with chronic breast implant infections/inflammation. Methods Current and new antimicrobial breast irrigations were tested via standard techniques for bactericidal activity against multiple Gram-positive and Gram-negative strains. Test results are detailed and clinical recommendations for current antimicrobial irrigations are provided. Results Betadine-containing irrigations were found to be superior according to the testing performed. Conclusions There are quite few misconceptions with regard to antimicrobial breast pocket irrigation. These are discussed and final evidence-based recommendations for practice are given.
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Chepla, Kyle J., and Arun K. Gosain. "Interstitial Pneumonitis After Betadine Aspiration." Journal of Craniofacial Surgery 23, no. 6 (2012): 1787–89. http://dx.doi.org/10.1097/scs.0b013e31826cf57b.

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15

Mindrup, Elizabeth A., Polly A. Dubbel, and Donald J. Doughman. "Betadine Decontamination of Donor Globes." Cornea 12, no. 4 (1993): 324–29. http://dx.doi.org/10.1097/00003226-199307000-00008.

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16

Waters, L. J., S. E. Barton, and F. C. Boag. "Betadine for herpes simplex infection." International Journal of STD & AIDS 17, no. 12 (2006): 854–55. http://dx.doi.org/10.1258/095646206779307487.

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Yasin, Asma, Samar Hussain, Mehvish Javeria, Saima Qurban, and Muhammad Naim Ashraf. "Normal Saline Versus Betadine use to Reduce the Incidence of Wound Infection in Cesarean Section, A Cross Sectional Comparative Study." Pakistan Journal of Medical and Health Sciences 16, no. 5 (2022): 270–72. http://dx.doi.org/10.53350/pjmhs22165270.

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Aims and Objectives: The aims and objectives of this study was to observed the difference between using betadine or normal saline irrigation of wound prior to skin closure in reducing the surgical site infections. Design of the Study: It’s a case-control study Study Settings: The study was conducted at Department of Obstetrics &Gynecology Rashid Latif Medical College, Lahore from June 2021 to November 2021. Material and Methods: For current study 200 pregnant women were selected and equally divided them into two different groups i.e. Group A and Group B. All individuals of Group A, used betadine liquid for surgical wound irrigation while the individuals of Group B, were used normal saline for such purpose. The observed raw data were statistically analyzed by SPSS 21, one –way ANOVA in which analysis of variance followed by mean standard deviation (Mean±SD) and P values (p<0.05) for significant. Results: The findings of current study indicated that wound irrigation with betadine liquid or normal saline have their own importance. The results are significant (p<0.05) in comparative analysis of Group A and Group B regarding allergy, postoperative wound cellulitis, postoperative wound abscess, postoperative fever and obstetric hemorrhages. Conclusion: The findings of current study indicated that Normal saline irrigation is better than betadine because of skin irritation and allergy due to iodine and toxicity of povadine iodine solution against healthy cells. Keywords: Cesarean delivery, surgical site infection, Normal saline, Betadine, surgical wound irrigation
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Kaplan, Joan C., David C. Crawford, Amy G. Durno, and Robert T. Schooley. "Inactivation of Human Immunodeficiency Virus by Betadine." Infection Control 8, no. 10 (1987): 412–14. http://dx.doi.org/10.1017/s0195941700066583.

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AbstractHuman immunodeficiency virus (HIV), the etiological agent of the acquired immunodeficiency syndrome (AIDS), was treated with either Betadine® (povidone-iodine) Solution or Betadine Surgical Scrub®. HIV inactivation was analyzed using the viral reverse transcriptase assay or by observing the cytopathic effect produced in HIV-infected, H-9, T-cell cultures. The minimum effective Betadine dose was 0.25% for complete inactivation of HIV that was treated for various time intervals (immediate vortex to ten minutes). The titer of HIV stocks used in these experiments (105 TCID50 per mL) was greater than amounts generally detected in clinical specimens. Our results provide a rationale for the use of povidone-iodine as a topical antiseptic against HIV in the clinic or laboratory.
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Bathula, Hanusha, Chiranjeevi Vedula, Harikrishna Reddy Sunkireddy, Venugopal Kunthsam, Manasa Dhulipala, and Manasa Akula. "Evaluation of Efficacy of Triphala as a Preprocedural Mouth Rinse - A Comparative Study." Journal of Evolution of Medical and Dental Sciences 10, no. 38 (2021): 3360–64. http://dx.doi.org/10.14260/jemds/2021/682.

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BACKGROUND The objective of the study was to determine the efficacy of Triphala as a preprocedural mouth rinse & comparing the efficacy with chlorhexidine and betadine in reducing the viable microbial load in dental aerosols. METHODS 32 patients with chronic periodontitis were randomly allocated into 4 groups (A, B, C & D) of 8 patients each who received 0.2 % chlorhexidine (CHX), 6 % Triphala (TRP), 2 % betadine and water respectively as a pre-procedural mouth rinse. Blood agar plates were placed on the operator’s chest area and the patient’s chest area for collecting the aerosols. The agar plates were then incubated at 370C for 48 hours and colony-forming units (CFUs) were counted. RESULTS CFU was significantly reduced in groups A, B & C compared to group D. Intergroup comparison showed no significant difference in the efficacy of 0.2 % CHX and 6 % TRP with P-value 0.058 in the operator’s area and with a significant difference of Pvalue 0.014 in the patient’s area. 2 % betadine was found to be least effective among the 3 test groups. The number of CFUs was greater at the patient’s chest area than that of the operator. CONCLUSIONS This study reinforces the importance of preprocedural mouth rinse. Triphala showed near equal efficacy to CHX, which is considered the gold standard in aerosol reduction and also better than 2 % betadine. Therefore, it can be considered as an alternative to CHX as a preprocedural mouth rinse. KEY WORDS Triphala, Chlorhexidine, Betadine, Aerosols, Colony Forming Units (CFUs)
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Sadri, Amir, Saif Rhobaye, and Ali Juma. "Breast implant information identification: Betadine smear." Journal of Plastic, Reconstructive & Aesthetic Surgery 67, no. 2 (2014): e62. http://dx.doi.org/10.1016/j.bjps.2013.09.025.

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21

Dron, І. A., N. M. Bukartyk, M. M. Bukartyk, D. D. Ostapiv, and V. Ya Samaryk. "PREPARATION OF ANTISEPTIC HYDROGEL PLATES BASED ON NATURAL POLYSACCHARIDES." Chemistry, Technology and Application of Substances 5, no. 2 (2022): 178–84. http://dx.doi.org/10.23939/ctas2022.02.178.

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Using natural polysaccharides, pectin and sodium alginate, hydrogel plates capable of absorbing exudate were obtained. Studies have shown no cytotoxicity of the plate material. In order to create bactericidal therapeutic dressings based on them, the possibility of filling the plates with antiseptics (iodine, betadine, chlorhexidine) was shown and their release dynamics was studied. Studies have shown that the release of iodine from the plate is too fast and can not meet the condition of its prolonged release in contrast to betadine and chlorhexidine.
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22

Vanamala, Milly, Brett Hartman, and Madeline Zieger. "601 A Simple Dressing for Prevention of Central Line Infections in Pediatric Burn Patients." Journal of Burn Care & Research 41, Supplement_1 (2020): S143—S144. http://dx.doi.org/10.1093/jbcr/iraa024.227.

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Abstract Introduction Between 2017 and 2018, the burn unit saw 16 patients with major burns. A major burn is considered a total body surface area of 20% or greater. The burns ranged from 20% to 85% total body surface area averaging 44.14 %. Of those 16 patients, 8 patients required central lines that could not utilize a traditional occlusive central line dressing. Central line access is often placed near a burn or grafted site, and an occlusive dressing cannot be maintained. On average, a central line was changed in the operating room every seven days for infection prevention or sooner if an infection is suspected. The lines were changed preferably to a new site or over a wire if limited sites. In 2017, our Burn unit’s central line associated bloodstream infection rate of 4.1 infections per 1000 catheter days. This was higher than the national benchmark centerline from the Children’s Hospital Solutions for Patient Safety national collaborative for pediatric intensive care units of 1.365 infections/1000 catheter days. The unit implemented the use of a 4x4 betadine dressing for microbial coverage as an innovative strategy to prevent central line associated blood infections. The method not only proved to be effective but also cost efficient. Methods While the standard of changing the central line every 7 days remained the same, our unit began using a 4x4 gauze soaked in betadine and placed over the central line insertion site. The gauze is moistened with the betadine solution, then rung out so that the gauze is not oversaturated. That gauze is placed directly over the insertion site using sterile technique. A dry gauze is then placed over the wet one to protect from pathogens in the environment. Both gauze pads are then changed every 4 hours to keep the betadine moist and working as an antimicrobial agent. Results In 2018, 4 patients with various central lines utilized the betadine technique with our overall central line associated blood infection rate for 2018 decreased to 0 infections/1000 catheter days. The cost of each occlusive central line dressing in our facility is $2.10, whereas the betadine method costs $0.97. These supplies can be used for more than one dressing change on each patient compared to the occlusive dressing that is used once. Conclusions Using the betadine dressing technique to protect against central line associated bloodstream infections has proven to be an effective, low cost technique to prevent line infections and improve patient outcomes for major burn patients with compromised skin integrity. By utilizing this technique, our overall central line infection rate has dropped significantly below the national average, while decreasing cost by over 50%. Applicability of Research to Practice Maintaining a low cost, effective dressing to help prevent line infections in major pediatric burn patients.
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Singh, Bhavkeerat, Sudershan Kapoor, and Arun Kumar Gupta. "Comparing the efficacy of nano crystalline silver dressing versus betadine dressing in management of diabetic foot ulcer." International Surgery Journal 7, no. 5 (2020): 1424. http://dx.doi.org/10.18203/2349-2902.isj20201568.

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Background: The incidence of diabetes and its complications is rising as a result of the lifestyle changes. The foot is most frequent site for complication in patients with diabetes. Dressings have a vital part to play in the management of wounds. The ideal antiseptic is one that is lethal to all forms of bacteria, has no deleterious effect on healing tissues, delineates the operative areas, easily applied and has wide spectrum of activity and absence of acquired bacterial resistance. Nanotechnology makes it possible to expand the surface area of silver particles markedly to nanoscale. They expand the surface area of silver particles increasing their contact with bacteria.Methods: In the proposed study, over a period of 18 months, 60 cases (30-30 in 2 groups) of diabetic foot ulcers were studied with respect to response (healing) to nano silver dressing and betadine dressing after dividing them randomly. Assessment was based on various parameters like size reduction, healthy granulation tissue, etc.Results: It was seen that percentage reduction in size, was more in nano silver group as compared to betadine group. Wounds were managed successfully, early in nano silver group and wound healing was better in nano silver group as compared to betadine group. Also, nano silver was better antimicrobial.Conclusions: The prospective study showed nano silver gel is safe and effective in wound management and gives better efficacy and faster response as compared to traditional betadine dressing.
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Benli, Erdal, Abdullah Cirakoglu, Ercan Ogreden, et al. "Does Leaving the Biopsy Needle in Povidone-Iodine Solution Reduce Infective Complications after Biopsy?" Advances in Urology 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/6841837.

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Aim. The aim of this study is to evaluate whether leaving the biopsy needle used during prostate needle biopsy in 10% povidone-iodine (betadine) solution affects the infectious complications forming after biopsy. Material and Method. This study retrospectively evaluated the data of 176 patients with prostate biopsy performed between December 2012 and April 2014. Patients in Group 1 (n=89) were given ofloxacin as a prophylactic antibiotic before biopsy. Patients in Group 2 (n=87) had the biopsy needle left in povidone-iodine solution for 1 minute before each use, in addition to antibiotic prophylaxis. The two groups were compared in terms of infective complications developing after biopsy. Results were analyzed using the Mann–Whitney U test and Fisher’s exact test. Results. The distribution of infective complications after biopsy according to group was as follows. Group 1, not using betadine, had 15.7% fever, 13.5% hospital stay, 12.4% urinary retention, 10.1% prostatitis, and 5.6% sepsis. The distribution of the same complications in Group 2 using betadine was identified as 5.7% fever, 4.6% hospital stay, 3.4% urinary retention, 2.3% prostatitis, and 0% sepsis. The use of betadine was found to significantly reduce the infectious complications after biopsy compared to the control group (p<0.05). Conclusion. At the end of this study leaving the prostate needle in povidone-iodine solution before each use during prostate biopsy was found to reduce the infective complications and hospital stay after biopsy.
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Xu, Peter Z., John R. Fowler, and Robert J. Goitz. "Prospective Randomized Trial Comparing the Efficacy of Surgical Preparation Solutions in Hand Surgery." HAND 12, no. 3 (2016): 258–64. http://dx.doi.org/10.1177/1558944716658856.

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Background: Decontamination of the skin prior to incision is part of the standard of care for any surgical procedure. Previous studies have demonstrated variable efficacy of different surgical preparation solutions based on anatomic location. The purpose of this study is to determine the effectiveness of 3 commonly used surgical preparation solutions in eliminating bacteria from the skin prior to incision for common elective soft tissue hand procedures. Methods: A total of 240 patients undergoing clean, elective, soft tissue hand surgery were prospectively randomized to 1 of 3 groups (ChloraPrep, DuraPrep, or Betadine). Prepreparation and postpreparation cultures were obtained adjacent to the surgical incision and neutralization was performed on the obtained specimen. Cultures were held for 14 days and patients followed for 6 weeks postoperatively. Results: Postpreparation cultures were positive in 21 of 80 (26.3%) ChloraPrep patients, 3 of 79 (3.8%) DuraPrep patients, and 1 of 81 (1.2%) Betadine patients ( P < .001). There was no difference in the postpreparation culture rate between DuraPrep and Betadine ( P = 1.000). Conclusions: Duraprep and Betadine were found to be superior to Chloraprep for skin decontamination prior to clean elective soft tissue hand surgery. The bacterial flora of the hand was found to be different from those of the shoulder and spine. The clinical significance of this finding requires clinical consideration because the majority of prepreparation and postpreparation positive cultures were of Bacillus species, which are rarely a cause of postoperative infections.
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Sastrodihardjo, Sumadhi, and Kholidina Imanda Harahap. "The Evaluation of Flow Property of Alginate Impression Material Mixed with Gargle Solutions." Jurnal Material Kedokteran Gigi 7, no. 2 (2018): 33. http://dx.doi.org/10.32793/jmkg.v7i2.371.

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The effects of antiseptic and gargle solutions mixed with the irreversible hydrocolloid alginate impression material to anti-bacterial activity and several properties had been elucidated. The flow property of the such impression has been not elucidated yet. The aim of the study was to evaluate the flow property of alginate impression mixed with gargle solution. Aroma Fine Plus alginate impression material was used and mixed with aquadest as control and Minosep, Betadine and Total Care gargle solutions. Ratio between alginate and each solutions were performed by following the producer’s guidance as 8.4gr alginate and 20ml solution. The every alginate mixtures were made in triplicate (n=3). Measurement of flow capability was performed by using 0.5ml of alginate mix laid on glass plate covered with cellophane strip and loaded with 1kg metal for 1 minute. The major and minor diameters were measured by using digital caliper. Data were analyzed by using one way ANOVA (α= 0.05). Aroma Fine mixed with aquadest showed the flow capability was about 26.18mm. Mixed with Minosep showed about 27.85mm, with Betadine 29.19mm and Total Care 27.11mm respectively. Statistically show a significant different flow capability between aquadest and Betadine mixed impression (p=0.01). Minosep and Total Care gargle solutions showed insignificant different with aquadest mixed impression (p>0.05). It can be concluded that the utilizing of Minosep and Total care gargle solution as solutions mixed with alginate impression material have no effect to flow property of the impression, except by using Betadine gargle solution.
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Ghobrial, George M., Michael Y. Wang, Barth A. Green, et al. "Preoperative skin antisepsis with chlorhexidine gluconate versus povidone-iodine: a prospective analysis of 6959 consecutive spinal surgery patients." Journal of Neurosurgery: Spine 28, no. 2 (2018): 209–14. http://dx.doi.org/10.3171/2017.5.spine17158.

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OBJECTIVEThe aim of this study was to determine the efficacy of 2 common preoperative surgical skin antiseptic agents, ChloraPrep and Betadine, in the reduction of postoperative surgical site infection (SSI) in spinal surgery procedures.METHODSTwo preoperative surgical skin antiseptic agents—ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol) and Betadine (7.5% povidone-iodine solution)—were prospectively compared across 2 consecutive time periods for all consecutive adult neurosurgical spine patients. The primary end point was the incidence of SSI.RESULTSA total of 6959 consecutive spinal surgery patients were identified from July 1, 2011, through August 31, 2015, with 4495 (64.6%) and 2464 (35.4%) patients treated at facilities 1 and 2, respectively. Sixty-nine (0.992%) SSIs were observed. There was no significant difference in the incidence of infection between patients prepared with Betadine (33 [1.036%] of 3185) and those prepared with ChloraPrep (36 [0.954%] of 3774; p = 0.728). Neither was there a significant difference in the incidence of infection in the patients treated at facility 1 (52 [1.157%] of 4495) versus facility 2 (17 [0.690%] of 2464; p = 0.06). Among the patients with SSI, the most common indication was degenerative disease (48 [69.6%] of 69). Fifty-one (74%) patients with SSI had undergone instrumented fusions in the index operation, and 38 (55%) patients with SSI had undergone revision surgeries. The incidence of SSI for minimally invasive and open surgery was 0.226% (2 of 885 cases) and 1.103% (67 of 6074 cases), respectively.CONCLUSIONSThe choice of either ChloraPrep or Betadine for preoperative skin antisepsis in spinal surgery had no significant impact on the incidence of postoperative SSI.
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Norma, Norma, O. Lopulalan, and Randy Prayogi. "PERBEDAAN EFEKTIVITAS PERAWATAN VULNUS LACERATUM (LUKA ROBEK) MENGGUNAKAN BETADINE DAN NaCl TERHADAP KECEPATAN PENYEMBUHAN." Nursing Arts 13, no. 1 (2019): 69–75. http://dx.doi.org/10.36741/jna.v13i1.88.

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Kejadian Vulnus Laceratum atau luka akibat benda tumpul sangat sering kita jumpai, halini dapat disebabkan oleh banyaknya terjadi kecelakaan, baik itu kecelakaan kerja maupun kecelakaan di jalanraya. Angka kejadian vulnus laceratum yang terjadi pada tahun 2016 di RSUD Sele Be Solu adalah 374 orang. Penelitian ini dilakukan untuk mengetahui perbedaan efektivitas perawatan vulnus laceratum (lukarobek) menggunakan betadine dan NaCl. Jenis penelitian ini adalah eksperimen menggunakan desain quasi eksperimen. Jumlahsampel 20 responden yang dilakukan dengan Sample Random Probability. Analisa penelitian ini menggunakanuji Paired Sample T- Test. Dan hasil dari penelitian ini adalah betadine maupun NaCl tidak ada perbedaan dalam kecepatan penyembuhan vulnu slaceratum (lukarobek).
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Malarvizhi, R., Poddar Abhishek, R. Barathidasan, Kanuga Kishore K., and HR Vasanthi. "Potential Wound Healing Properties of a Polyherbal Formulation (Amrit oil) in an Experimental Model on Wistar Rats." Biomedicine 39, no. 1 (2020): 40–51. http://dx.doi.org/10.51248/.v39i1.220.

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Introduction and Aim: Wound healing is an integrated process of cellular and biochemical events in restoring the structural functionality of the damaged tissue caused due to wounds. In the present study, the wound healing potential of an ayurvedic polyherbal formulation, Amrit oil is tested on an experimental model of the excisional wound in Wistar rats and evaluated for its potent activity in wound repair.
 Materials and Methods: Wistar rats were randomly arranged into 4 groups with 6 in each. Excision wound was created on the dorsal side of the rats. Group-I was kept as a negative control, Group-II as reference control, treated with Betadine, Group-III received a tropical application of Amrit oil once in a day and Group- IV were subjected to tropical application of amrit oil twice or Bis in a day. The wound healing was assessed by percentage wound contraction, a period of epithelisation, histopathological analysis and expression of MMP- 2, MMP-8, KGF and HSP-90.
 Results: The effect produced by the ayurvedic polyherbal formulation (Amrit oil), in terms of percentage wound contraction, a period of epithelisation, biochemical gene expression (MMP2, MMP8, HSP90 and KGF) and histopathological analysis were comparable to that of standard drug betadine. This study reveals the healing potential of Amrit oil as compared to the positive control, betadine possibly due to the presence of the phytochemicals in a synergistic manner.
 Conclusion: This study revealed a tremendous healing potential of Amrit oil as compared to the positive
 control, betadine in a holistic manner, confirming the rationality of the traditional knowledge.
 
 
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Sitepu, Kuat, Anita Srigandaria Purba, Arfah May Sara, and Widya . "HUBUNGAN PENGGUNAAN BETADINE SALEP TERHADAP KEJADIAN FLEBITIS PADA TEMPAT PEMASANGAN INFUS INTRAVENA DI RUMAH SAKIT TENTARA TINGKAT IV 01.07.01 PEMATANGSIANTAR TAHUN 2021." JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) 4, no. 1 (2021): 1–7. http://dx.doi.org/10.35451/jkf.v4i1.770.

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Background : The incidence of ebitis is one indicator of the quality of hospital services with the standard set by The Infusion Nursing of Practice, which is 5%. The incidence of phlebitis is an indicator of minimum hospital service quality with a standard incidence of ≤1.5%. Purpose : Knowing the effect of using betadine ointment on the incidence of phlebitis at the intravenous infusion site at the Army Hospital TK IV. 01.07.01 Pematangsiantar. Methods : This type of research the researcher used was a quasi experiment with the equivalent control group design. The research instrument used was an observation sheet with a sample of 30 patients who had an intravenous infusion attached. Results: There was a significant effect of using betadine ointment on the incidence of phlebitis on intravenous infusion therapy. Statistical analysis using normality test, homogeneity and hypothesis testing. Conclusions and suggestions : The use of betadine ointment against the incidence of phlebitis at the intravenous infusion site has a significant relationship. Therefore the hospital management must continue to make efforts to improve services to patients. As a suggestion, room nurses should increase their knowledge through training on infection control and prevention, nosocomial infection prevention training in hospitals.
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Welch, Janet S. "In Response The Use of Betadine Solution." Nurse Practitioner 20, no. 6 (1995): 7???25. http://dx.doi.org/10.1097/00006205-199506000-00001.

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Becker, Hilton. "THE EFFECT OF BETADINE ON SILICONE IMPLANTS." Plastic and Reconstructive Surgery 105, no. 4 (2000): 1570–71. http://dx.doi.org/10.1097/00006534-200004000-00062.

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Becker, J. Hilton, and Craig D. Becker. "The Effect of Betadine on Silicone Implants." Plastic & Reconstructive Surgery 105, no. 4 (2000): 1570. http://dx.doi.org/10.1097/00006534-200004040-00063.

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Becker, Hilton. "THE EFFECT OF BETADINE ON SILICONE IMPLANTS." Plastic and Reconstructive Surgery 106, no. 7 (2000): 1665. http://dx.doi.org/10.1097/00006534-200012000-00056.

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Patel, Kunal S., Brandon Goldenberg, and Theodore H. Schwartz. "Betadine irrigation and post-craniotomy wound infection." Clinical Neurology and Neurosurgery 118 (March 2014): 49–52. http://dx.doi.org/10.1016/j.clineuro.2013.12.015.

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Eggers, Maren, Markus Eickmann, and Juergen Zorn. "BETADINE® Solution, BETADINE® Skin Cleanser, BETADINE® Surgical Scrub, and BETASEPTIC® demonstrated excellent virucidal in-vitro efficacy against Ebola virus Zaire and Modified vaccinia virus Ankara." Journal of Microbiology, Immunology and Infection 48, no. 2 (2015): S133. http://dx.doi.org/10.1016/j.jmii.2015.02.469.

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Nurullin, R. M., R. M. Abdrakhmanov, and R. R. Khaliullin. "New opportunities for local therapy of pustular skin diseases." Kazan medical journal 93, no. 2 (2012): 214–16. http://dx.doi.org/10.17816/kmj2291.

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Aim. To study the effectiveness of a universal antiseptic Betadine (international nonproprietary name - povidone-iodine) in the treatment of pustular skin diseases. Methods. The study had the form of an open, non-comparative one, which involved 25 patients aged from 2.5 to 40 years (mean age 16.1±1.2 years) with disease duration from 1 to 7 days (mean 4.2±0.8) with various forms of pyoderma: 21 patients with streptococcal impetigo and 4 patients with folliculitis. Assessment of safety of the study was carried out on the basis of clinical and laboratory data, patient tolerability of the substance, the expert-opinion of the physician-researcher. Changes in the quality of life as a result of treatment of patients with pyoderma using Betadine solution was evaluated by a questionnaire SKINDEKS-29. Results. All patients willing used the proposed betadine solution. No reasons for discontinuation of treatment during the study (including side effects, allergic reactions or exacerbation of the cutaneous process) were identified. Deterioration of the quality of life on the «Emotions» scale of SKINDEKS-29 questionnaire at the beginning of treatment was 49.8±1.3 points («sometimes»), during the second visit - 26.8±0.9 points («rarely»), by the end of treatment (third visit) - 10.2±0.3 points («no»); on a scale of «Function» at the beginning of treatment - 77.8±1.8 («often»), during the second visit - 53.2±1.6 («sometimes»), by the end of treatment - 16.2±0.8 points («no»); on a scale of «Symptoms» at the beginning of treatment - 51.2±1.3 («sometimes»), during the second visit - 27.6±2.8 («rarely»), by the end of treatment - 12.3±0.3 points («no»). Conclusion. Betadine is characterized by high clinical efficacy in pustular skin diseases, good tolerance, absence of adverse reactions, a positive impact on the quality of life and can be recommended as a therapeutic and prophylactic agent.
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Kira, Е. F., I. A. Simchera, and T. K. Tikhonov. "The use of betadine for the treatment of dysbiotic and fungal diseases of the vagina in pregnant women." Journal of obstetrics and women's diseases 51, no. 3 (2021): 101–2. http://dx.doi.org/10.17816/jowd91109.

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Elkasapy, A., and and Ibrahim. "Contribution to reconstruction of third degree rectovestibular lacerations in mares." Open Veterinary Journal 5, no. 2 (2015): 23. http://dx.doi.org/10.5455/ovj.2015.v5.i1.p23.

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The study was conducted on ten mares suffering from third degree rectovestibular laceration. Four uterine washes were performed in all cases by using diluted betadine (mixing 5ml of betadine antiseptic solution in 1 liter of sterile saline) to control vaginal and uterine infections before surgery. Surgical repair of third degree rectovestibular laceration was done by one-stage Goetz technique after four to six weeks of initial injury, with the lateral dissection continued extensively until the two flaps were created and brought to the midline without any tension. Primary healing occurred in all cases without significant complications. The obtained results indicate that mares with third degree rectovestibular lacerations are candidates for uterine wash and one-stage Goetz technique with excessive lateral continuation of the flap.
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Gala, Monil Yogesh Neena, and Swanand S. Pathak. "Evaluation of wound healing activity of Hibiscus rosa sinensis linn in albino rats." International Journal of Basic & Clinical Pharmacology 8, no. 6 (2019): 1303. http://dx.doi.org/10.18203/2319-2003.ijbcp20192194.

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Background: From debridement to the appearance of healthy granulation tissue is the maximum time during which the patient suffers more economically and psychologically. Due to high cost expenditure in hospitalisation, dressing material cost and loss of daily earnings during this period which puts a psychological pressure over patient and family especially in India where majority of the population is still below poverty line. Also access to quick treatment is yet not possible to majority of population living in rural with no access to basic healthcare.Methods: It was an experimental study wherein Wistar rat models were used to check for the wound healing property of Hibiscus Rosa Sinensis (HRS) compared with one of the common standard drugs of treatment for available today, betadine. To observe the wound healing property of the HRS flower extract, the experiment was divided into 2 parts i.e. excision wound model and incision wound model. The groups were treated with respective medication along with a control group of rats.Results: At the end of the experiment, it was observed that HRS flower extract increased the wound breaking strength as compared to control but not as effectively as compared to the betadine ointment.Conclusions: HRS flower extract helps in early epithelization and helps in decreasing the wound size. Betadine is associated with adverse events like life threatening allergic reactions, water retention, etc.
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Bawotong, Repatri A., Edwin De Queljoe, and Deby A. Mpila. "UJI EFEKTIVITAS SALEP EKSTRAK DAUN JARAK PAGAR (Jatropha curcas L.) TERHADAP PENYEMBUHAN LUKA SAYAT PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus)." PHARMACON 9, no. 2 (2020): 284. http://dx.doi.org/10.35799/pha.9.2020.29283.

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ABSTRACTJatropha leaves (Jatropha curcas L.) contains alkaloid, saponin, tannin, terpenoid, steroid, glycoside, phenol compound and flavonoid through ethanol extract. Until today the community still used the plant as a wound healing medicine. The aim of this study is to examine the effectiveness of jatropha curcas L. leaf extract ointment for healing in male white rats wistar strain. Jatropha leaves extract ointment was tested on 5 which consists of 3 rats in each treatment groups, that is base ointment (negative control), ointment betadine (positive control), ointment extract of Jatropha leaves 10%, 20% and 40%. Observations has made until the 14th day. And data were tested using ANOVA (Analysis of Variants) and continued with LSD (Least Significant Different) test. Statistical test results showed a difference in the duration of wound healing in male white rats wistar strain between the ointment extract of jatropha leaf with ointment betadine and vaseline ointment. Keywords: Ointment, Jatropha extract (Jatropha curcas L.), Galur wistar, Wound.ABSTRAK Daun jarak pagar (Jatropha curcas L.) mengandung zat-zat alkaloid, saponin, tannin, terpenoid, steroid, glikosida, senyawa fenol dan flavonoid melalui ekstrak etanol. Hingga saat ini masyarakat masih menggunakan tanaman tersebut sebagai obat penyembuh luka. Penelitian ini bertujuan untuk menguji efektivitas salep ekstrak etanol daun jarak pagar terhadap penyembuhan luka sayat pada tikus putih jantan galur wistar. Salep ekstrak daun jarak pagar diujikan pada hewan uji tikus sebanyak 5 yang terdiri dari 3 ekor tikus disetiap kelompok perlakuan, yaitu basis salep (kontrol negatif), salep betadine (kontrol positif), salep ekstrak etanol daun jarak pagar 10%, 20% dan 40%. Pengamatan dilakukan sampai hari ke 14. Data diuji dengan menggunakan ANOVA (Analisis Of Variant) dan dilanjutkan dengan uji LSD (Least Significant Different). Hasil uji statistik menunjukan adanya perbedaan terhadap lamanya penyembuhan luka pada tikus putih jantan galur wistar antara sediaan salep ekstrak daun jarak pagar dengan salep salep betadine dan basis salep. Kata Kunci: Salep, Daun jarak pagar (Jatropha curcas L.), Galur wistar, Luka sayat.
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Носенко, О. М., Т. Я. Москаленко, and А. В. Рутинская. "Povidon-iodine (betadine) in modern obstetric-gynecological practice." Reproductive Endocrinology, no. 44 (December 28, 2018): 43–48. http://dx.doi.org/10.18370/2309-4117.2018.44.43-48.

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Adams, William P., W. Chad H. Conner, Fritz E. Barton, and Rod J. Rohrich. "Optimizing Breast-Pocket Irrigation: The Post-Betadine Era." Plastic and Reconstructive Surgery 107, no. 6 (2001): 1596–601. http://dx.doi.org/10.1097/00006534-200105000-00049.

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Hwang, Kae Yong, Byung Chun Mun, Jong Soo Choi, Ki Hong Kim, and Jong Chul Ahn. "Two Cases of Allergic Contact Dermatitis to Betadine." Yeungnam University Journal of Medicine 3, no. 1 (1986): 387. http://dx.doi.org/10.12701/yujm.1986.3.1.387.

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Hershlag, A., H. Feng, and G. M. Scholl. "Betadine (povidone-iodine) is toxic to murine embryogenesis." Fertility and Sterility 76, no. 3 (2001): S117. http://dx.doi.org/10.1016/s0015-0282(01)02343-3.

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Hershlag, A. "Betadine (povidone-iodine) is toxic to murine embryogenesis." Fertility and Sterility 79, no. 5 (2003): 1249–50. http://dx.doi.org/10.1016/s0015-0282(03)00159-6.

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Wiener, Thomas C. "The Role of Betadine Irrigation in Breast Augmentation." Plastic and Reconstructive Surgery 119, no. 1 (2007): 12–15. http://dx.doi.org/10.1097/01.prs.0000251088.51675.a8.

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Zambacos, George J., Apostolos D. Mandrekas, and Robert J. Morris. "The Role of Betadine Irrigation in Breast Augmentation." Plastic and Reconstructive Surgery 120, no. 7 (2007): 2115. http://dx.doi.org/10.1097/01.prs.0000287435.03556.73.

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Gray, Paul EA, Constance H. Katelaris, and Diane Lipson. "Recurrent anaphylaxis caused by topical povidone-iodine (Betadine)." Journal of Paediatrics and Child Health 49, no. 6 (2013): 506–7. http://dx.doi.org/10.1111/jpc.12232.

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Kundal, Ajay, Manu Kohli, and Sudershan Kapoor. "A comparative study on topical recombinant human epidermal growth factor vs conventional betadine dressing in management of diabetic wounds." International Surgery Journal 8, no. 1 (2020): 115. http://dx.doi.org/10.18203/2349-2902.isj20205868.

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Abstract:
Background: Major complications of diabetes mellitus include cardio vascular disease, chronic kidney disease, diabetic foot ulcers and non-healing wounds. Lack of knowledge and awareness has led to worsening of wounds which can involve deeper tissues and bones also. If treated on time majority of patients can be prevented from undergoing major debilitating surgical procedures such as amputation of toes, foot etc.Methods: In this proposed study, 60 cases of diabetic wounds were studied for healing who were randomly allocated into two groups of 30 patients each. Group A included topical recombinant epidermal growth factor (EGF) application and group B included conventional Betadine dressing for wound healing.Results: Anaemia had a significant role in delaying wound healing in group B patients. Blood sugars had no significant role in delaying wound healing in this study as patients in group A had mean FBS more than group B and still the wound healing was observed better in group A patients. Topical recombinant EGF resulted in faster wound healing than conventional dressings in diabetic wounds. 90% wound healing rates were seen with topical EGF dressings in comparison to 36.67% in conventional betadine dressings. Signs of wound healing i.e., early granulation, decreased discharge, early wound closure were seen faster in group A. Moreover, all patients in group A showed healthy granulation tissue by the end of our study.Conclusions: We concluded that topical recombinant EGF resulted in faster and better wound healing than conventional betadine dressing.
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