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Journal articles on the topic 'Betel chewers mucosa'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Shetty, Archana, Chahita Verma, and Vijaya Chowdappa. "Frequency of micronuclei in oral mucosal smears of female municipal sweepers with betel quid chewing practice." Journal of Pathology of Nepal 11, no. 1 (2021): 1847–51. http://dx.doi.org/10.3126/jpn.v11i1.31677.

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Background: Oral cancer is common worldwide. Study of micronuclei in exfoliated buccal mucosal cells holds great scope in bio monitoring their carcinogenic potential. Betel quid chewing is one of the most common factors contributing to oral cancers. Ours being a developing country, a study was undertaken among female municipal sweepers, majority of who are betel quid chewers, unaware of the harmful effects of the same. We attempted to cytologically access the presence and compare the proportion of micronuclei in the right, left buccal mucosa and hard palate of female municipal sweepers with an

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2

Jayanthi, K., G. Supadminidevi, Bina Shah, and R. Kamala. "Evaluation between Betel Quid and Pan Masala/Gutkha Habitual Chewers with OSMF." World Journal of Dentistry 3, no. 1 (2012): 37–40. http://dx.doi.org/10.5005/jp-journals-10015-1125.

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ABSTRACT Introduction The increasing use of pan masala/gutkha, a mix of tobacco and a less moist form of betel quid lacking the betel leaf, is associated with an earlier age of onset of oral submucous fibrosis. Hence, current study was conducted to evaluate and compare clinical, histopathological and cytological features of OSMF due to betel quid (BQ) and pan masala/gutkha chewing (PMG). Materials and methods Patients who had habit of chewing BQ or PMG and who were suffering from OSMF were selected for the study. Buccal mucosal smears were obtained from 30 controls, BQ and PMG chewers. Incisio

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3

Hasan, Md Masud Bin, Binoy Kumar Biswas, Tanjhila Akhter, et al. "Pattern of Oral Cancer between Smokers and Smokeless Tobacco Chewers in a Tertiary Care Hospital." Journal of Dentistry and Allied Science 7, no. 1 (2024): 8–15. https://doi.org/10.3329/jdas.v7i1.78814.

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Background: Oral cancer is one of the most common cancers in Bangladesh and subcontinent region. In countries where tobacco consumption is common and had social recognition, there oral cancer shows the highest prevalence. In Bangladesh many people are under multiple risk factors of oral squamous cell carcinoma. The objective of this study is to evaluate the pattern of oral cancer between smokers and smokeless tobacco chewers and to see the association of oral cancer with smoking and smokeless tobacco habits. Methods: This cross-sectional, observational study was conducted in the Bangabandhu Sh

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4

Lo, Y. T., H. F. Yang, Y. Y. Jou, C. Y. Wu, R. C. Chen, and Y. W. Wang. "The Effect of a Financial Incentive Designed of Transtheoretical Model–Based Interventions on Betel Quid Cessation." Journal of Global Oncology 4, Supplement 2 (2018): 234s. http://dx.doi.org/10.1200/jgo.18.94200.

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Background: Betel quid (BQ) and cigarette smoking (CS) are oral cancer risk factors. It has been estimated that hundreds of million people mainly in the Asia-Pacific region were consume certain variety of BQ. BQ is the fourth most commonly used psychoactive substance in the world and require assist the chewers to withdraw it. In Taiwan, Health Promotion Administration (HPA) has initiated a hospital-based in-reach screening services for oral cancer to chewers and smokers since 2010 and proposed a financial incentive BQ cessation program designed based on Transtheoretical Model (TTM) to BQ chewe

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5

Amarasinghe, Hemantha, WFD Ananda, SKD Hariachandra, et al. "An Assessment of the Effectiveness of an Intervention to Quit Tobacco Use in Patients Seek Treatment from the Institute of Oral Health, Maharagama, Sri Lanka." Asian Pacific Journal of Cancer Care 8, no. 3 (2023): 529–32. http://dx.doi.org/10.31557/apjcc.2023.8.3.529-532.

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Background: Tobacco is consumed in both smoked and smokeless forms. STEP Survey Sri Lanka 2015 showed that 29.4% males and 0.1% females were current smokers, Smokeless Tobacco (SLT) use was found in 26% of males and 5% of females. Dental setting could be considered as a suitable venue to provide brief health education message to persuade quit from tobacco. The aim of this study was to assess the effectiveness of brief intervention among tobacco users attending the Institute of Oral Health, Maharagama, Sri Lanka. Methods: Dental Surgeons provide routine care for the patients at the OPD and asse

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6

Lin, Wen-Jiun, Rong-San Jiang, Shang-Heng Wu, Fun-Jou Chen, and Shih-An Liu. "Smoking, Alcohol, and Betel Quid and Oral Cancer: A Prospective Cohort Study." Journal of Oncology 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/525976.

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We aimed to investigate the association between smoking, alcoholic consumption, and betel quid chewing with oral cancer in a prospective manner. All male patients age ≥18 years who visited our clinic received an oral mucosa inspection. Basic data including personal habits were also obtained. A multivariate logistic regression model was utilized to determine relevant risk factors for developing oral cavity cancer. A total of 10,657 participants were enrolled in this study. Abnormal findings were found in 514 participants (4.8%). Three hundred forty-four participants received biopsy, and 230 pat

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7

Chuang, Hui-Ching, Ming-Hsien Tsai, Yu-Tsai Lin, Ming-Huei Chou, Kun-Lin Yang, and Chih-Yen Chien. "Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer." Technology in Cancer Research & Treatment 21 (January 2022): 153303382211468. http://dx.doi.org/10.1177/15330338221146870.

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The major predisposing factors of developing oral cancer include smoking, alcohol drinking, and betel quid chewing. Betel quid chewing could cause the abrasion and damage of oral mucosa by crude fibers, chemical insults by additive slaked lime, and arecoline from areca nut. These would lead to the local consequence of oral submucosal fibrosis, which is regarded clinically as a precancer lesion and a major cause of trismus. In addition, the components and additives in betel quid contain chemical toxins and carcinogens, which would further affect the oral mucosa and gradually develop a malignanc

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8

Ansu, Ann Abraham, Denny E. Ceena, Manaktala Nidhi, Natarajan Srikant, Ahmed Junaid, and Yadav Utkarsh. "Assessment of Genotoxic Effects of Various Forms of Smokeless Tobacco Using Micronuclei Assay." Transylvanian Review XXVI, no. 25 (2018): 6739–44. https://doi.org/10.5281/zenodo.6237318.

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Aim: To assess the micronuclei assay based on age and gender variability from the buccal mucosal cells in patients using various forms of smokeless tobacco. Materials and Methods: A cross sectional study was conducted among sixty eight individuals who had a history of chewing various forms of smokeless tobacco. The study subjects were divided according to their habits into four groups. The groups were arecanut, betel quid, gutkha and control group. Buccal smears were obtained and the exfoliated cells were stained using Feulgen stain. The micronuclei count was done under 40X magnification and c

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9

Javed, F., H. C. Tenenbaum, G. Nogueira, et al. "Oral Candida carriage and species prevalence amongst habitual gutka-chewers and non-chewers." International Wound Journal 11, no. 1 (2014): 79–84. https://doi.org/10.1111/j.1742-481X.2012.01070.x.

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Oral Candida colonisation is higher in tobacco smokers as compared to non-smokers; however, it remains unknown whether smokeless tobacco chewers are susceptible to increased oral Candida colonisation. The aim was to determine the oral Candida carriage and species prevalence amongst habitual gutka-chewers and non-chewers in a cohort from Karachi, Pakistan. Forty-five gutka-chewers and 45 non-chewers were included. Information regarding age, sex, duration of gutka-chewing habit, daily frequency of gutka consumption, duration of holding gutka in the mouth, daily frequency of tooth-brushing and to

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10

Wu, Shyh-Jong, Yun-Ju Chen, Tien-Yu Shieh, et al. "Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral Disorders." Scientific World Journal 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/160185.

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BQ chewing may produce significant amounts of reactive oxygen species (ROS), resulting in oral mucosa damage, and ROS may be metabolized by CYP26 families. Because the CYP26 polymorphisms associated with malignant oral disorders are not well known, we conducted an association study on the associations between the single nucleotide polymorphisms (SNP) of CYP26 families and the risks of malignant oral disorders. BQ chewers with the CYP26A1 rs4411227 C/C+C/G genotype and C allele showed an increased risk of oral and pharyngeal cancer (adjusted odds ratio (aOR) = 2.30 and 1.93, respectively). The

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11

Gatoo, Manzoor, and Ayaz Dar. "Cyclin D1 expression of different histological grades in oral squamous cell carcinoma patients from northern India." Archive of Oncology 24, no. 1 (2018): 6–9. http://dx.doi.org/10.2298/aoo180312001g.

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Cyclin D1 expression was positive in 35 cases of oral cancer with a Cyclin D1 positivity of 22.16?22.18. The percentage of positive cases as well as Cyclin D1 positivity showed an increase as the grade of differentiation advanced. No significant association was found between Cyclin D1 positivity and degree of differentiation of tumors (p=0.138). A significant difference in Cyclin D1 positivity was observed (p=0.043) comparing well differentiated (16.61?17.89) and poorly differentiated (37.0?32.51) tumors, as well as between well differentiated (16.61?17.89) and moderately differentiate tumors

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12

Barma, Parometa, Ibrahim Khalil, and Tanzima Yeasmin. "Rural profile of oral squamous cell carcinoma (OSCC) survival patients attending in tertiary level hospital in Bogura: a hospital based retrospective observational study." Update Dental College Journal 10, no. 1 (2020): 3–5. http://dx.doi.org/10.3329/updcj.v10i1.46684.

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Developing country like Bangladesh among 90% of oral malignant neoplasm are arising from squamous layer of oral epithelium which are third leading of this country with severe disfiguration, functiolaesa, psychological impairments and socio-economic hardship. In this study we found the prevalence of OSCC was 6.5% among total cancer patients in the two tertiary level hospitals of Bogura. Male (70%) are affected more than in females (30%). In response to male and female parameter, sex distribution ratio was 2.3:1. The prevalent average age was 55.40 years. About 80% of ulcer site was buccal mucos

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13

Nair, U., G. Obe, J. Nair, et al. "Evaluation of frequency of micronucleated oral mucosa cells as a marker for genetoxic damage in chewers of betel quid with or without tobacco." Mutation Research/Genetic Toxicology 261, no. 3 (1991): 163–68. http://dx.doi.org/10.1016/0165-1218(91)90063-r.

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14

Sailor, Nisha. "Prevalence of oral submucous fibrosis in gandhinagar: a demographic study." International Medical Healthcare 1, no. 1 (2023): 1–6. http://dx.doi.org/10.62908/imh.01.01.00007.

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Background: Oral submucous fibrosis (OSMF) is now globally accepted as an Indian disease. It has one of the highest rates of malignant transformation among potentially malignant oral lesions and conditions, therefore, a cause of concern for oral healthcare professionals. The present study aims to evaluate the prevalence of OSMF among betel nut chewers in different age groups in patients visiting Dental College and Hospital Gandhinagar, India. Materials and Methods: A total of 100 patients of OSMF visiting the dental outpatient clinic of the Department of Oral Medicine and Radiology Goenka rese

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15

Reichart, P. A., and H. P. Philipsen. "Betel chewer's mucosa - a review." Journal of Oral Pathology & Medicine 27, no. 6 (2007): 239–42. http://dx.doi.org/10.1111/j.1600-0714.1998.tb01949.x.

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16

Reichart, P. A., W. Schmidtberg, and Ch Scheifele. "Betel chewer's mucosa in elderly Cambodian women." Journal of Oral Pathology and Medicine 25, no. 7 (1996): 367–70. http://dx.doi.org/10.1111/j.1600-0714.1996.tb00280.x.

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17

Triani, Maulina, Akbar Aulia Hidayat, Aris Aji Kurniawan, Anindita Laksitasari, and Aditya Priagung Prakosa. "Pyknotic Cell Features of Buccal Mucosal Smear in Various Oral Lesions of Betel Nut Chewers." Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva 11, no. 1 (2022): progress. http://dx.doi.org/10.18196/di.v11i1.14561.

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The habit of chewing betel nut is one of the predisposing factors that can trigger the formation of various oral lesions and develop into a malignant condition in the form of oral squamous cell carcinoma (OSCC). This malignancy has a low five-year survival rate as early detection is not widely carried out. Early detection can be conducted by examining pyknotic cells to describe the level of apoptosis. This study aims to examine the pyknotic cell features as a marker of apoptosis in various oral lesions found in betel nut chewers. This study is an analytic survey conducted once with a post-test

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18

JAFFRI, SB, F. IRFAN, B. JAM, B. RAHMAT, SA PIRZADA, and M. SIBGHATULLAH. "COMPARATIVE ANALYSIS OF ORAL SUBMUCOUS FIBROSIS AND LICHEN PLANUS: INSIGHTS FROM PATIENT SURVEYS." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1339. https://doi.org/10.54112/bcsrj.v2024i1.1339.

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Oral Submucous fibrosis (OSMF) and Lichen planus (LP) are chronic diseases of the oral mucosa that have different causes and manifestations. OSMF is primarily associated with betel quid chewers showing progressive fibrosis with functional derangement and a high propensity for malignant change. LP, on the other hand, is an immune-mediated disease that presents with a wide range of symptoms and contrarily, has a lower severity of complications associated with it. Although there is much written on both conditions’ knowledge of the relative clinical characteristics, psychological effects, and func

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19

Palliyal, S. "Assessment of Betel Quid Habits and Risk of Precancerous Oral Lesions Among Paniya Tribes of Wayanad, India - A Cross-Sectional Study." Journal of Global Oncology 4, Supplement 2 (2018): 12s. http://dx.doi.org/10.1200/jgo.18.16700.

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Background: Betel quid habits in India is widely prevalent and responsible for increased incidence of head and neck cancer in the country. Head and neck cancer is a major public health problem among Paniya tribes, a marginalized tribal group in Kerala state, India. Previous studies among Paniya tribals in Wayanad have documented a high prevalence of betel quid habit. Oral leukoplakia (OL) and oral submucous fibrosis (OSF) are the most common oral mucosal diseases that have a very high malignant transformation rate. Aim: Aim of this study was to evaluate the risks imposed by betel quid habits i

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20

Munpolsri, Pattaranan, Chiu-Wen Su, Sam Li-Sheng Chen, and Amy Ming-Fang Yen. "Behavior Changes for Smokers and Betel Quid Chewers Participating in the Organized Oral Mucosal Screening Between 2010 and 2021 in Taiwan." Cancers 17, no. 3 (2025): 397. https://doi.org/10.3390/cancers17030397.

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Objective: To investigate the likelihood of smoking and betel quid chewing behavior changes, as well as the associated factors, among subjects in a nationwide oral cancer screening program in Taiwan, where oral cancer is the fourth leading malignancy in men. Methods: The Taiwanese Oral Cancer Screening Program targets smokers and betel quid chewers over the age of 30. Between 2010 and 2021, 2,578,245 individuals participated in the program at least twice. During each visit, the central data monitoring center collected information on gender, age, education level, smoking and betel quid chewing

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Su, Shih-Yung. "Evaluation of Nationwide Oral Mucosal Screening Program for Oral Cancer Mortality among Men in Taiwan." International Journal of Environmental Research and Public Health 19, no. 21 (2022): 14329. http://dx.doi.org/10.3390/ijerph192114329.

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The nationwide oral cancer screening program was launched for high-risk people (tobacco smokers or betel-nut chewers) in 1999 in Taiwan, but no study has taken the prevalence of tobacco smoking and betel-nut chewing into account for evaluating the impact of the screening program on oral cancer mortality. This study incorporated the risk fraction method with interrupted time-series analysis to evaluate the impact of the nationwide oral mucosal screening program among men in Taiwan. This study estimated the expected oral cancer mortality trend if the screening program had not launched in 1999, w

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22

Lee, Chien-Hung, Albert Min-Shan Ko, Cheng-Fang Yen, et al. "Betel-quid dependence and oral potentially malignant disorders in six Asian countries." British Journal of Psychiatry 201, no. 5 (2012): 383–91. http://dx.doi.org/10.1192/bjp.bp.111.107961.

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BackgroundDespite gradual understanding of the multidimensional health consequences of betel-quid chewing, information on the effects of dependent use is scant.AimsTo investigate the 12-month prevalence patterns of betel-quid dependence in six Asian populations and the impact of this dependence on oral potentially malignant disorders (OPMD).MethodA multistage random sample of 8922 participants was recruited from Taiwan, mainland China, Indonesia, Malaysia, Sri Lanka and Nepal. Participants were evaluated for betel-quid dependency using DSM-IV and ICD-10 criteria and assessed clinically for ora

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Noufal, Ahammed, Antony George, Maji Jose, Mohasin Abdul Khader, and Cheriyanthal Sisupalan Jayapalan. "Cytomorphometric Analysis of Oral Buccal Mucosal Smears in Tobacco and Arecanut Chewers Who Abused With and Without Betel Leaf." Substance Abuse 35, no. 1 (2014): 89–95. http://dx.doi.org/10.1080/08897077.2013.812053.

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Rupa, D. "Chromosomal alterations affecting the 1cen-1q12 region in buccal mucosal cells of betel quid chewers detected using multicolor fluorescence in situ hybridization." Carcinogenesis 18, no. 12 (1997): 2347–51. http://dx.doi.org/10.1093/carcin/18.12.2347.

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25

Reddy, D. Indraneel, M. Lakshmi Narayana, Vivek Viswambharan, and N. Reddy Chaithanya. "Betel quid and tobacco chewing habits and its associated clinical findings in a rural tertiary care hospital." International Journal of Otorhinolaryngology and Head and Neck Surgery 6, no. 4 (2020): 732. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20201291.

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<p class="abstract"><strong>Background:</strong> Among all forms of tobacco, smokeless tobacco is known to be more carcinogenic than smoking according to various studies. Smokeless tobacco is consumed through various forms in our region like kaddipudi, gutkha, khaini, pan, etc. This study aims at evaluating the different chewing patterns of tobacco and to assess their impact on the oral mucosa.</p><p class="abstract"><strong>Methods:</strong> The patients who attended ENT department with the habit of chewing tobacco were taken into this study after con

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Marbun, Dame R. "Gambaran Kebiasaan Menyirih dan Lesi Mukosa Mulut pada Mahasiswa Papua Di Manado." e-GIGI 1, no. 2 (2013). http://dx.doi.org/10.35790/eg.1.2.2013.3204.

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Kebiasaan menyirih telah dilakukan sejak dahulu kala di Indonesia, khususnya pada suku Papua. Banyak anggapan masyarakat bahwa menyirih dapat menguatkan gigi geligi dan menghambat terjadinya karies, namun dibalik dampak positif dari menyirih ini, ada juga dampak negatifnya berupa timbulnya lesi pada mukosa yang melapisi rongga mulut.Tujuan penelitian ini yaitu untuk memperoleh gambaran kebiasaan menyirih pada mahasiswa Papua di Kota Manado, mencakup: tujuan menyirih, bahan campuran menyirih, lamanya kebiasaan menyirih, frekuensi menyirih, dan faktor pendorong kebiasaan menyirih serta untuk men

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27

Zain, R. B., P. Siwamogstham, T. Axell, J. Thampipit, and D. Tantiniran. "Prevalence of oral soft-tissue lesions in out-patients at 2 Malaysian and Thai dental schools." Blackwell Publishing, April 1, 1990. https://doi.org/10.5281/zenodo.811281.

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At the Faculties of Dentistry in Chiang Mai, Thailand (CM), and Kuala Lumpur, Malaysia (KL), 234 and 233 consecutive out-patients of mean ages 33.8 and 31.0 yr, respectively, were examined for the presence of oral mucosal lesions. Tobacco in some form was regularly used by 31.7% and 27.5% of the study populations in CM and KL, respectively. Cigarette smoking was the predominant habit. In CM three persons chewed betel quids and nine smoked banana leaf cigars daily. In addition, there were 24 habitual chewers of tea leaves (miang). In KL six persons chewed betel quids daily. In CM and KL three c

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Rahman, Z. A. A., R. B. Zain, Z. Abang, et al. "Oral mucosal lesions in Indigenous people of Sarawak and their related habits." January 1, 1999. https://doi.org/10.5281/zenodo.811261.

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The Malaysian nationwide survey on oral mucosal lesions (OML) in 1993/94 showed a low prevalence of OML in particular oral cancer and precancer (OPC) among the Malays as compared to the Indians and the Indigenous people of Sabah and Sarawak. A low prevalence of quid chewing habit was also noted in the Malays in that survey. The present study was conducted to investigate whether the low prevalence of OPC in the Malays was attributed to the low prevalence of quid users among the Malays and/or whether the quid contents used were different. Two examiners were trained prior to the survey. The inter

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Raman, R. A., Z. A. A. Rahman, R. B. Zain, et al. "Oral mucosal lesions in Malay quid and non-quid chewers in Kelantan." June 19, 2017. https://doi.org/10.5281/zenodo.811263.

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The Malaysian nationwide survey on oral mucosal lesions (OML) in 1993/94 showed a low prevalence of OML in particular oral cancer and precancer (OPC) among Malays as compared to the Indians and the Indigenous people of Sabah and Sarawak. A low prevalence of quid chewing habit was also noted in the Malays in that survey. The present study was conducted to investigate whether the low prevalence of OPC in the Malays was attributed to the low prevalence of quid users among the Malays and/or whether the quid contents used were different. Two examiners were trained prior to the survey. The interexam

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Zain, R. B., H. Fukano, N. Ikeda, et al. "Tenascin-C in betel-quid associated lesions." May 1, 1999. https://doi.org/10.5281/zenodo.811295.

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The expression of Tenascin-C, an adhesion modulating or anti- adhesive extracellular matrix protein, was evaluated in betel quid associated lesions of oral mucosa showing focal hyperkeratosis (n=15), dysplasia (n=15), oral submucous fibrosis (n=7) and oral squamous cell carcinoma (n=8). All the patients were chewers of betel quid containing betel leaves, areca nuts, lime and tobacco. The results obtained from this study were compared to similar lesions in smokers and non-quid users cited in the literature (Shrestha et al, Oral Oncol, 1994). An enhanced expression of TN-C was observed in epithe

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Kipli, N.P., S.K.S. Kumar, R. B. Zain, C.Y. Fan, and P.K. Boon. "Expression of p53, pRb, Ki-67 and bcl-2 in betel quid induced oral mucosal lesions." Elsevier, April 1, 2005. https://doi.org/10.5281/zenodo.811217.

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Introduction: The variability of clinical outcomes in oral cancer patients and the heterogeneity of the disease are the main challenges for the improvement of current treatment modalities. Efforts in our laboratory have focused on the molecular profiling of oral cancer to understand the mechanisms underlying the disease. In a previous microarray study, we found Guanine nucleotide binding protein alpha-12 (GNA12) to be up-regulated in oral cancer. Materials and methods: In this study, we validated the expression of GNA12 at the mRNA level in 47 oral squamous cell carcinoma (OSCC) and 18 non-mal

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Zain, R. B., N. Ikeda, P. C. Gupta, et al. "Oral mucosal lesions associated with betel quid, areca nut and tobacco chewing habits: Consensus from a workshop held in Kuala Lumpur, Malaysia, November 25-27, 1996." January 1, 1999. https://doi.org/10.5281/zenodo.811259.

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A variety of betel/areca nut/tobacco habits have been reviewed and categorized because of their possible causal association with oral cancer and various oral precancerous lesions and conditions, and on account of their widespread occurrence in different parts of the world. At a recent workshop in Kuala Lumpur it was recommended that 'quid' be defined as 'a substance, or mixture of substances, placed in the mouth or chewed and remaining in contact with the mucosa, usually containing one or both of the two basic ingredients, tobacco and/or areca nut, in raw or any manufactured or processed form.

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Zain, R. B., R. J. R. Latifah, I. A. Razak, et al. "Oral cancer and precancer research in Malaysia - the database and tissue resource bank." Elsevier, January 1, 2005. https://doi.org/10.5281/zenodo.811239.

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Introduction: Uncoordinated data collection by different research groups prompted the initiation of Malaysian oral cancer Research Initiative (MOCRI) group. Objectives: To coordinate and standardize data and tissue collection and storage, develop a minimum dataset on risk factors, intervention techniques and quality of life of oral cancer patients. Materials and Methods: A computer software programme is currently being developed to accommodate multi-centre data collection and research activities in eight hospitals. The complete dataset includes parameters on sociodemographic, clinical, patholo

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Ghani, W. M. N., I. A. Razak, Y. H. Yang, et al. "Factors affecting commencement and cessation of betel quid chewing behaviour in Malaysian adults." January 1, 2011. https://doi.org/10.5281/zenodo.811219.

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Background. Betel quid chewing is a common habit widely practiced in Southern Asian populations. However, variations are seen in the content of a betel quid across the different countries. Factors associated with commencement and cessation of this habit has been numerously studied. Unfortunately, data on Malaysian population is non-existent. This study aims to determine the factors associated with the inception and also cessation of betel quid chewing behaviour among Malaysian adults. Method. This study is part of a nationwide survey on oral mucosal lesions carried out among 11,697 adults in a

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Zain, R. B., A. Anwar, L. P. Karen-Ng, et al. "Selected transcriptome profiles of oral cancer suggestive of field cancerisation using second generation sequencing." Blackwell Publishing, January 1, 2010. https://doi.org/10.5281/zenodo.811289.

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Objectives: To characterize differential gene expression between oral cancerous tissues and the normal mucosal tissues of oral cancer patients and oral mucosal tissues of cancer free patients using second generation sequencing. Methods: Five fresh frozen oral cancer tissue samples from smoking patients, with 2 samples of proximal normal were included in this study. An additional 8 samples consisting of normal oral mucosal tissues from the alveolar mucosa of non-cancer patients who had their wisdom tooth removed where 4 were smokers and another 4 were non-smokers was also included. The tissues

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Primasari, A. "Habitual Betel Quid Chewing Patterns and the Risk of Oral Potentially Malignant Disorders: Population-Based Case Control Study." Journal of Dental Science Research Reviews & Reports, September 30, 2022, 1–4. http://dx.doi.org/10.47363/jdsr/2022(4)134.

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Habitual betel quid chewing is known as risk factor of oral potentially malignant disorders. Comprehensive data on the history of usage patterns and the risk of oral mucosal disorders related to the habitual betel quid chewing had previously been limited in numerous Indonesian populations. The purpose of this study was to investigate the risk of habitual betel quid chewing patterns on the oral potentially malignant disorders in Samosir Island, province of North Sumatra Indonesia. The present study was conducted to the habitual chewers of betel quid in the working area of the local government c

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Zain, R. B., L. P. Karen-Ng, S. C. Cheong, et al. "Effects of smoking on oral cancer transcriptome." Elsevier, July 1, 2011. https://doi.org/10.5281/zenodo.811209.

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Introduction: Oral cancer is a debilitating disease and the survival rates for these patients have not improved over the past decades. Tobacco smoking is one of the most common risk factor associated with oral cancer. Objectives: To explore and identify differential genes expression associated with tobacco smoking. Methodology: Next generation sequencing using the Illumina Genome Analyzer was done to sequence five fresh frozen oral cancer tissue samples from smoking patients, two of which were former smoker and an additional 8 samples consisting of normal oral mucosal tissues from the alveolar

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"Micronuclei (Oral Cancer Biomarker) Study in Buccal Mucosal Cell with Betel Quid Chewers among Indian Population." ARC Journal of Cancer Science 2, no. 1 (2016). http://dx.doi.org/10.20431/2455-6009.0201005.

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Zain, R. B., N. Ikeda, I. A. Razak, et al. "A national epidemiological survey of oral mucosal lesions in Malaysia." Blackwell Publishing, October 1, 1997. https://doi.org/10.5281/zenodo.811167.

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The prevalence of oral mucosal lesions in Malaysia was determined by examining a representative sample of 11 707 subjects aged 25 years and above throughout the 14 states over a period of 5 months during 1993/1994. A two-stage stratified random sampling was undertaken. A predetermined number of enumeration blocks, the smallest population unit in the census publication was selected from each state. With the selected enumeration block, a systematic sample of living quarters was chosen with a random start. The survey instrument included a questionnaire on sociodemographic characteristics and a cl

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Hussaini, H. M., P. K. Lim, R. A. Rahman, et al. "Expression of human b-defensin-3 in oral squamous cell carcinoma using tissue microarray - A preliminary study." Blackwell Publishing, August 1, 2006. https://doi.org/10.5281/zenodo.811215.

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Purpose: Human b-Defensin (hBDs) is an epithelial origin, cationic antimicrobial peptides. Their expression is reported in oral mucosa, gingiva and salivary glands. However, their protective role is not well understood. It has been suggested that bacterial and viral infection are an important factors in the process of carcinogenesis. This study investigated the expression of hBD-3 in oral squamous cells carcinoma (OSCC). Methods: 29 OSCC and 23 samples of normal and dysplastic tissues were obtained from Oral Pathology diagnostic laboratory, faculty of Dentistry, UKM and UM. The tissues were ar

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Zain, R. B., A. R. Rusdi, N. Ghazali, and A. R. Samsudin. "Oral cancer incidence in Kelantan, Malaysia." Elsevier, January 1, 2001. https://doi.org/10.5281/zenodo.811271.

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Aim: A pilot study was carried out in the state of Kelantan, north-east of Malaysia, to determine the feasibility of using pathological and hospital databases to acquire incidence on oral cancer. Method: Data on OC patients (ICD-10: C00.3-00.5, C02-06) were obtained from incident surgical biopsy records of the two main referral centres for head and neck surgery in Kelantan namely, the Department of Pathology, Faculty of Medicine, University of Science and the Oral Surgery clinic, Kota Baru Hospital between January 1994 to December 1998. The crude and age-specific incidence rates were calculate

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42

Jalil, A. A., R. B. Zain, and der Waal I. van. "Darier disease: a case report." Elsevier, January 1, 2005. https://doi.org/10.5281/zenodo.811199.

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Darier disease, also known as keratosis follicularis, dyskeratosis follicularis, and benign dyskeratosis, is a rare disorder of keratinisation that primarily affects the skin and, to a lesser extent, the oral mucosa. It was described independently by both Darier and White in 1889. It has a prevalence of 1:100,000 of the population and is inherited as an autosomal dominant trait.1 The age of onset is childhood or adolescence. Patients usually present with multiple small firm reddish-brown papules on the forehead, scalp, neck, shoulders, chest, and limbs. Other cutaneous signs include punctate k

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Khandelwal, Vishal, Hallaswamy V. Kambalimath, Naveen B. Reddy, Sushma Khandelwal, Vanaja Reddy, and Nitu Gupta. "Oral submucous fibrosis in a school-going Indian adolescent boy." International Journal of Adolescent Medicine and Health 30, no. 5 (2017). http://dx.doi.org/10.1515/ijamh-2016-0096.

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Abstract A 14-year-old boy presented to our hospital with a chief complaint of difficulty in opening his mouth and a burning sensation on eating spicy food. The oral mucosa showed generalized diffused blanching and he was unable to protrude his tongue. For 6 years he had habitually chewed gutkha – a mixture of betel nut and tobacco for several minutes a day. This oral submucous fibrosis condition is very rare in young patients. The case highlights the link between oral submucous fibrosis and the regular use of areca nut (gutkha) products in a young boy.

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Zaini, Z. M., L. P. Karen-Ng, S. C. Cheong, et al. "Genetic polymorphisms and risk of oral cancer." Blackwell Publishing, January 1, 2010. https://doi.org/10.5281/zenodo.811225.

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Objectives: This study was done to investigate the role of single nucleotide polymorphisms(SNPs) within genes of phase I (CYP1A1) and phase II (GSTM1, GSTT1,GSTP1) of the xenobiotic metabolism and its association with oral cancer risk.Methods: An unmatched case-control study was conducted using 207 newly diagnosed oral cancer patients and 117 non-cancer subjects selected from the OCRCC database. Peripheral blood was obtained from consented individuals and the CYP1A1, GSTM1, GSTT1 and GSTP1 genotypes were determined using polymerase chain reaction (PCR) and restriction enzyme digestion (RFLP).

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Farini, M. S., A. Azlina, I. Rushdan, M. Manoharan, R.B. Zain, and A. R. Samsudin. "Clinical pathological evaluation and risk factors of oral cancer cases of east coast of peninsular Malaysia." Elsevier, April 1, 2005. https://doi.org/10.5281/zenodo.811183.

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Introduction: Oral cancer is one of the common cancers m Malaysia. Tile population of east coast of Peninsular Malaysia has a different hfestyle and Malay is the predominant race. Oral cancer research in this area started since the Malaysian National Oral Cancer group was established. The am: of this study is to evaluate the clinical pathological findings and to investigate the role of tobacco smoking, alcohol consurnption and betel quid chewing as tile risk factors among oral cancer cases m east coast of peninsular Malaysia.Materials and Methods: Fifty case records of only treated/operated ca

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Ali, T. B. Taiyeb, I. A. Razak, R. J. Raja Latifah, and R. B. Zain. "An epidemiological survey of oral mucosal lesions among elderly Malaysians." Blackwell Publishing, July 1, 1995. https://doi.org/10.5281/zenodo.811181.

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A house to house random survey on elderly subjects was undertaken in the District of Klang in Malaysia. The objective of this study was to investigate the prevalence of oral mucosal lesions (OML) among the elderly in this area. The primary units in the sampling frame were the Enumeration Blocks (EBs) as defined under the population census. All households of the selected EBs were considered as sampling units and members aged 60 and above were considered as respondents. There was a slight preponderance of females, with the Malays comprising the majority of the subjects. Of the 486 respondents, m

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Zain, R. B., and L. S. Koh. "The occurrence of oral-mucosal lesions among employees of a steelmill--a preliminary study." January 1, 1988. https://doi.org/10.5281/zenodo.811301.

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A study has been conducted on 198 employees of a steel-mill industry. These participants were examined for mucosal lesions in the oral cavity and including the commissures and vermillion borders of the lips. The prevalences of 16 types of lesions are reported. This record was migrated from the OpenDepot repository service in June, 2017 before shutting down.

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Karen-Ng, L. P., J. Marhazlinda, Z. A. A. Rahman, M. T. Abraham, S. C. Cheong, and R. B. Zain. "Combined effects of isothiocyanates (ITCs) intake, glutathione S-transferases (GSTs) polymorphism and risk habits on oral squamous cell carcinoma (OSCC) associated with earlier age of disease onset." Elsevier, July 1, 2011. https://doi.org/10.5281/zenodo.811191.

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Introduction: ITCs found in cruciferous vegetables has been reported to reduce cancer risk by inducing phase II conjugating enzymes, in particular GSTs. Interestingly, these enzymes also metabolize ITCs therefore; the protective effects of ITCs would depend on the activity of GSTs. This study aimed to determine association between dietary ITCs, GSTs polymorphisms and risk habits (cigarette smoking, alcohol drinking and betel-quid chewing) with oral cancer.Method: Included in this study were 115 OSCC patients and 116 healthy subjects. Information on ITC intake from cruciferous vegetables was co

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Zain, R. B., and I. A. Razak. "ASSOCIATION BETWEEN CIGARETTE-SMOKING AND PREVALENCE OF ORAL MUCOSAL LESIONS AMONG MALAYSIAN ARMY PERSONNEL." Blackwell Publishing, January 1, 1989. https://doi.org/10.5281/zenodo.811165.

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The association between cigarette smoking and the prevalence of oral mucosal lesions was examined in 495 Malaysian army personnel. No associations between cigarette smoking and recurrent aphthous ulcerations, pre-leukoplakia and frictional keratosis could be obtained in this study. Positive associations were found between cigarette smoking and leukoedema as well as denture stomatitis. There was a negative association between cigarette smoking and the presence of coated tongue. This record was migrated from the OpenDepot repository service in June, 2017 before shutting down.

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50

Karen-Ng, L. P., W. M. N. Ghani, A. Vimmitra, et al. "Aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferase M1 (GSTM1) polymorphisms in relation to oral cancer risk among Malaysians." Elsevier, June 19, 2017. https://doi.org/10.5281/zenodo.811177.

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Introduction: ALDH2 is an enzyme involved in major oxidative pathway of alcohol metabolism while GSTM1 is a drug-metabolizing enzyme of acetaldehyde. It has been reported that the mutant ALDH2 allele and the absence of GSTM1 contributes to increased oral cancer risk due to reduced acetaldehyde metabolism. This study aims to determine ALDH2 and GSTM1 polymorphisms and its association with oral cancer risk. Method: An unmatched case-control study was conducted using 163 oral cancer patients and 87 non-cancer subjects selected from the OCRCC database. ALDH2 and GSTM1 genotypes were determined usi

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