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Relevant bibliographies by topics / Bi-layered Tablet of Divalproex Sodium

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Academic literature on the topic 'Bi-layered Tablet of Divalproex Sodium'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Bi-layered Tablet of Divalproex Sodium"

1

RAJPUT, RAJVEER SINGH, and BALA KUMAR CHANDRASEKARAN. "FORMULATION AND IN VITRO EVALUATION OF DIVALPROEX SODIUM BI-LAYERED TABLET." Current Research in Pharmaceutical Sciences 12, no. 3 (2022): 138–46. http://dx.doi.org/10.24092/crps.2022.120303.

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Divalproex sodium is the anticonvulsant agents that used in the treatment certain types of seizures. The aim of the present study is to formulate and evaluate divalproex sodium bilayer tablet. Divalproex Sodium Bi-layer tablets (BLT) were prepared by simple blending and punching with HPMC, Xanthan Gum, Sodium starch glycolate, MCC, PVP, and Magnesium stearate. Optimized formulation was designed on the basis of best formulation of the immediate release layer and sustained release layer. The pre and post compression parameters were evaluated and stability studies of the optimized formulation was

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2

Acharya, Ankit, Mohammed Gulzar Ahmed, Ravi Chaudhari, and Renukaradhya Chitti. "Formulation and Development of Divalproex Sodium Bi-Layered Tablets using Superdisintegrants and Release Retardant Polymers." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 2 (2017): 3669–75. http://dx.doi.org/10.37285/ijpsn.2017.10.2.5.

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 Divalproex sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy and bi-polar disorders and prophylaxis of migraine. The present work has been done to formulate bi-layered tablet of Divalproex sodium containing immediate release layer and sustained release layer. The FTIR study revealed that there was no interaction between drug and polymer and combination. Both layers were prepared by wet granulation technique as poor flow property exhibited by pure drug. The immediate release layer was formulated by using superdisintegrants and evaluat

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3

Agam, Kumar Chaubey* Ashok Baghel Dinesh Sharma Yogendra Singh. "Formulation And Evaluation of Bi-Layered Tablet of Divalproex Sodium." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 501–13. https://doi.org/10.5281/zenodo.14993024.

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The pharmacokinetic advantage relies on the criterion that, drug release from the fast-releasing layer leads to a sudden rise in the blood concentration. However, the blood level is maintained at steady state as the release from sustained layer. Particularly bilayer tablets are commonly used to avoid chemical incompatibilities of formulation components by physical separation, and release profile. The tablet is the most widely used dosage form because of its convenience in terms of self-administration, compactness and ease in manufacturing.4 Tablets are solid dosage forms containing medicinal s

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4

Saniya, Mubarik*1 Rajni Dubey2 Bhaskar Kumar Gupta3 Mariya Beg4. "A Research Article: Formulation and Evaluation of By-Layered Tablet of Divalproex Sodium." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2797–809. https://doi.org/10.5281/zenodo.15099861.

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Divalproex sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy and bi-polar disorders and prophylaxis of migraine. The present work has been done to formulate bi-layered tablet of Divalproex sodium containing immediate release layer and sustained release layer. The FTIR study revealed that there was no interaction between drug and polymer and combination can be safely prepared. Both layers were prepared by wet granulation technique as poor flow property exhibited by pure drug. The immediate release layer was formulated by using sodium starch

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5

Gunda, Dr Raghavendra Kumar, and Dr Tirumala Devi Kolli. "DEVELOPMENT AND IN-VITRO ASSESSMENT OF DIVALPROEX SODIUM BILAYERED TABLETS." Journal of Applied Pharmaceutical Sciences and Research 7, no. 2 (2024): 46–52. http://dx.doi.org/10.31069/japsr.v7i2.08.

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Objective: The aim of the current research work is to develop a bi-layered Divalproex sodium tablet with an immediate release layer and a sustained release layer. Divalproex sodium is regarded as the most significant antiepileptic medication and is frequently used to treat bipolar illness, epilepsy, and migraine prevention. Methods: Wet granulation was used to prepare both (Immediate release, Sustained release) layers since Divalproex had poor flow properties. Superdisintegrants were used to produce the immediate release layer, which was then assessed for physical characteristics, disintegrati

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6

Salve, Bhumika* Zanjad Aniket Deshmukh Komal Kalamkar Tejas. "A Review on Formulation and Evaluation of BI- Layered Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4527–36. https://doi.org/10.5281/zenodo.15535200.

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In order to achieve biphasic drug administration, the current review concentrates on the formulation and assessment of a 100 mg bi layered tablet of Divalproex Sodium that combines immediate release (IR) and sustained release (SR) components. A stable combination of sodium valproate and valproic acid, divalproex sodium is used extensively to treat epilepsy, bipolar disorder, and migraine prevention. But because of its brief half-life, frequent administration is required, which may result in noncompliance from patients. An efficient method to get around these restrictions is to use a bilayer pi

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7

Mabuchan, Shaik, and Jagadeesh Babu B. "Formulation and Evaluation of Bi-Layered Tablet of Divalproex Sodium." Asian Journal of Medical and Pharmaceutical Sciences 12, no. 1 (2024): 34–40. http://dx.doi.org/10.30904/j.ajmps.2024.4657.

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8

Khan, Arib, Satkar Prasad, and Gaurav Dubey. "Formulation and evaluation of bi-layered tablet of divalproex sodium." Journal of Pharmacognosy and Phytochemistry 12, no. 2 (2023): 16–22. http://dx.doi.org/10.22271/phyto.2023.v12.i2a.14621.

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9

Jatav, Pooja, Ashok Baghel, and Dinesh Sharma. "Formulation and evaluation of bi-layered tablet of divalproex sodium." International Journal of Pharmacy and Pharmaceutical Science 7, no. 1 (2025): 19–25. https://doi.org/10.33545/26647222.2025.v7.i1a.146.

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10

Elmostafa Kamil Khalil Abbas. "Optimization and appraisal of Bi-layered tablets containing divalproex sodium to augment therapeutic effectiveness." International Journal of Science and Research Archive 15, no. 3 (2025): 006–7. https://doi.org/10.30574/ijsra.2025.15.3.1652.

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The current study aimed to optimize and evaluate bi-layered tablets of Divalproex Sodium designed for improved therapeutic effectiveness in the treatment of epilepsy, bipolar disorder, and migraine. The formulation combined an immediate release (IR) layer with a sustained release (SR) layer to ensure rapid onset and prolonged action. Compatibility studies confirmed no significant interaction between the drug and excipients. Evaluation of pre- and post-compression parameters including hardness, friability, drug content, and in vitro dissolution studies demonstrated desirable characteristics. Th

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