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Dissertations / Theses on the topic 'Biao yan'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Huang, Wenhui. "Gao xue li nv xing de ze ou biao zhun yan jiu." Shaanxi : Shaanxi shi fan da xue, 2008. http://anulib.anu.edu.au/anuonly/ebooks/chinese_thesis_35.nh.

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2

Qin, Bairong. "Dang dai Zhongguo de ai guo zhu yi biao yan : zai Hunan Miluo ji nian Qu Yuan /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?HUMA%202006%20QIN.

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3

Lam, Sau-yau. "Case studies of the performance of local form six students in Chinese individual oral presentation Xianggang zhong liu xue sheng ge ren duan jiang biao xian de ge an yan jiu /." Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/hkuto/record/B31960261.

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4

Loh, Ka-yee Elizabeth. "A study of Hong Kong primary school students' ability to express emotions in their Chinese writing Cong Zhong wen zuo wen yan jiu Xianggang xiao xue sheng de qing yi biao da neng li /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38300928.

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5

Lee, So-kam. "A comparison of Cantonese Transcriptions in Guangzhouhua zhengyin zidian and Changyongzi guangzhouhua duyinbiao "Guangzhou hua zheng yin zi dian" yu "Chang yong zi Guangzhou hua du yin biao" Yue yu zhu yin bi jiao yan jiu /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40736982.

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6

Liu, Yuk-ling. "A comparative study of the phonetic transcriptions in Changyongzi Guangzhouhua duyinbiao and Yueyin zhengdu zihui "Chang yong zi Guangzhou hua du yin biao" yu "Yue yin zheng du zi hui" zhu yin bi jiao yan jiu /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42926233.

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7

Cai, Qinghua. "Yan yi zhi bian : Wei Jin xuan xue zhong de yan shuo wen ti tan xi /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?HUMA%202007%20CAI.

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8

Liang, Yaoguo. "Shi zhen bian zheng lun zhi gui lü de wen xian yan jiu /." click here to view the abstract and table of contents, 2006. http://net3.hkbu.edu.hk/~libres/cgi-bin/thesisab.pl?pdf=b19987122a.pdf.

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9

Wong, Po-yee Emily. "A study of military mutiny at Chenqiao = Chenqiao bing bian zhi yan jiu /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25797451.

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10

Yu, Kwok Fai. "Xu Xueyi "Shi yuan bian ti" qing yu shi ge yuan liu yan jiu /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?HUMA%202005%20YU.

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11

Tung, Ga-bo. "Stories in San-yen concerning men's changing altitudes and mentalities upon attaining social success "San yan" zhong "Fa ji bian tai" gu shi zhu ti yan jiu /." Click to view the E-thesis via HKUTO, 1987. http://sunzi.lib.hku.hk/hkuto/record/B31949320.

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12

Huang, Songliang. "Bian ge zhong de xue xiao ling dao Xianggang "ai guo xue xiao" de ge an yan jiu /." online access from Digital Dissertation Consortium, 2006. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?3254535.

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13

Li, Men-dik. "The unfolding and transformation of Daoism in Hong Kong Xianggang dao jiao de fa zhan yu tui bian yan jiu /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39558204.

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14

Gao, Amy (Amy Ruiming). "Bio-inspired pressure sensing for active yaw control of underwater vehicles." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/79278.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 89-92).<br>A towed underwater vehicle equipped with a bio-inspired artificial lateral line (ALL) was constructed and tested with the goal of active detection and correction of the vehicle's yaw angle. Preliminary experiments demonstrate that a low number of sensors are sufficient to enable the discrimination between different orientations, and that a basic proportional controller is capable of keeping the vehicle aligne

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15

Wu, Tsz Wing. "Li Yu gai bian ju yan jiu : jian lun wen ren chuan qi yu shi min wen xue zhi rong he /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?HUMA%202006%20WU.

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16

Aragona, Mariaceleste. "Role of YAP/TAZ in Mechanotransduction." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422159.

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Cells perceive their microenvironment not only through soluble signals but also in term of physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined adhesiveness. By mechanotransduction systems, cells translate these stimuli into biochemical signals controlling multiple aspects of cell behavior, including growth, differentiation and cancer malignant progression; but how rigidity mechanosensing is ultimately linked to activity of nuclear transcription factors remains poorly understood. Here we report the identification of the Yorkie-homologues YAP and TAZ as nuclear

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17

Quaranta, Erika Giorgia. "Control of YAP/TAZ function in the nucleus." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427150.

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YAP and TAZ are two transcriptional co-regulators involved in controlling many important biological processes, such as tissue regeneration, proliferation, cell plasticity and tumorigenesis. Many upstream stimuli that regulate YAP/TAZ stability and nuclear localization have been described; yet, YAP/TAZ nuclear activity is largely underinvestigated. In this work, we will elucidate how YAP/TAZ are regulated in the nucleus and how they can exert their biological function.<br>YAP e TAZ sono due co-regolatori trascrizioni coinvolti nel controllo di molti processi biologici importanti, come la rigene

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18

Di, Biagio Daniele. "Role of YAP/TAZ in cell plasticity." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425714.

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The employment of somatic stem cells (SCs) as therapeutic elements is an important goal in the field of regenerative medicine. However, this is hampered by the fact that tissue stem cells are rare, difficult to purify and maintain in culture. Direct conversion of terminally differentiated cells back into their corresponding stem cells could provide a great effort in this sense. Here we show that ectopic YAP/TAZ expression in primary luminal differentiated cells of the mammary gland epithelium stably converts them into cells that display molecular and functional traits of mammary gland stem cel

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19

Panciera, Tito. "YAP/TAZ and somatic stem cells." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424816.

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The co-transcription factors YAP/TAZ are potent inducers of tissue and organ growth during development and tissue regeneration after damage. In this work we have expanded on the repertoire of YAP/TAZ regulations and on their biological properties. We found that these are regulated by the mechanical properties of the microenvironement and by the Wnt signaling cascade. The latter is induced by mutations in the tumor suppressor APC, a hallmark of intestinal cancer, and here we show that this is accompanied by YAP/TAZ stabilization and is functional for transformation of intestinal cells. Both the

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20

Santinon, Giulia. "Crosstalk between YAP/TAZ and Cellular Metabolism." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424412.

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The Warburg effect, the metabolic reprogramming of cancer cell toward aerobic glycolysis, occurs as a consequence of transformation carried out by several oncogenes. Aerobic glycolysis represents a metabolism particularly suited for cell growth, because it couples energy production to availability of chemical precursors for the biosynthesis of the main macromolecules (dNTPs, aminoacids and lipids). Metabolic reprogramming is usually considered as a simple phenotypic endpoint that occurs as a consequence of tumor formation. Growing evidences indicate, however, that metabolism on its turn can su

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21

chang, lei. "YAP/TAZ ACTIVITY AND MECHANISMS OF CELL PLASTICITY." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424489.

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In the last few years, YAP/TAZ emerged as powerful regulators of growth and tumor malignancy. YAP/TAZ are regulated by two inputs: the Hippo pathway and biomechanical pathway. The latter involves structural and physical signals that cells receive from their being attached to the substrate and/or to other cells and that chance the tension and organization of the cytoskeleton and cell shape. In previous works from our laboratory, we indeed found that specific F-actin structures, such as bundled F-actin cables and stress fibers are required to sustain YAP/TAZ activity. But the cascade intervening

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22

Hu, Xingdong. "Sheng cun fan shi li xing yu chuan tong : Yuan Ming Qing shi qi nan fang min zu fa lü bian qian yan jiu /." Beijing : Zhongguo she hui ke xue chu ban she, 2005. http://catalog.hathitrust.org/api/volumes/oclc/68159992.html.

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23

Lucon, Xiccato Romy. "Role of YAP/TAZ in liver tumorigenesis and mammary gland cells dedifferentiation." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3422692.

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YAP and TAZ are two transcriptional co-factors implicated in regulating fundamental biological processes, such as proliferation, regeneration, cell fate plasticity and tumorigenesis. Many upstream stimuli, such as the Hippo pathway and biomechanical inputs, regulate YAP/TAZ function. However, to date, our understanding of YAP/TAZ regulation is limited. Here I present our work on the role of SWI/SNF chromatin-remodeling complex, as YAP/TAZ nuclear inhibitor. By different in vitro assays, we found that SWI/SNF inactivation remarkably promotes YAP/TAZ-driven cell proliferation, and that the SW

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24

SAVORANI, CECILIA. "THE DUAL ROLE OF YAP IN DRIVING TGFß-MEDIATED ENDMT." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/557349.

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Endothelial-to-mesenchymal transition (EndMT) is a biological process that allows the transdifferentiation of endothelial cells into mesenchymal cells, thus originating cells capable of novel functions necessary for the surrounding environment. EndMT regulates endocardial cushion formation during embryo development, and it is stimulated by the TGFβ/BMP family of ligands. In adults, EndMT is activated upon an injury event or during pathological conditions like organ fibrosis, cerebral cavernous malformation, cancer-associated fibroblast generation, and others. Hence, it is necessary to better c

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25

Filippi, Letizia. "Epigenetic Control of YAP/TAZ-Mediated Transcription." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425760.

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An emerging paradigm in cancer biology relates to the concept of "transcriptional addiction" where transformed cells set high demand of general transcriptional regulators, chromatin modifiers and even the basal transcriptional machinery to sustain a dysregulated gene expression program. The mechanism and the players below these dependencies remained elusive. Identifying the most sensitive nodes of these regulations offers the potential of defining new targets and therapeutics with selective antitumor effects. Here we demonstrate that the two closely related transcriptional co-activator YAP an

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26

Longjan, Gurumwal George. "Bio-methane potential of exotic food waste and water hyacinth." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/13540.

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Region specific foods in the Niger Delta like yam and cassava are consumed on a daily basis by at least 70% of the population. In addition to other commonly consumed foods, high volumes of unavoidable food wastes are generated. With 78% of the households in the region disposing their waste by burying, burning or in unauthorised heaps, environmental degradation is sustained. The region also suffers an infestation of Water Hyacinth (WH). Anaerobic Digestion (AD) presents a viable way of managing these wastes in addition to providing a clean source of energy. Limited research has been conducted o

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27

Chen, Haochang. "Zhong yi yao zhi liao gong neng xing bian mi liao xiao wen xian ping gu /." click here to view the abstract and table of contents, 2006. http://net3.hkbu.edu.hk/~libres/cgi-bin/thesisab.pl?pdf=b19986919a.pdf.

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28

Ruggeri, Naomi. "REGULATION OF YAP BY GLUCOCORTICOIDS." Doctoral thesis, Università degli studi di Trieste, 2015. http://hdl.handle.net/10077/11122.

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2013/2014<br>The Hippo signalling pathway is tumour suppressor cascade with a central role in the regulation of fundamental cellular biological processes, such as cell proliferation, apoptosis, organ size control and stem cell functions. The Hippo pathway transduces external signals that come to the cell into the nucleus, where it can control the expression of specific target genes, mainly involved in cell proliferation and differentiation. The Hippo pathway is an inhibitory pathway that control by phosphorylation and inhibition Yes-associated protein (YAP) coactivator, one of the two nuclear

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29

Liang, Wanru. "Shen yi "Fa hua jing" de quan shi guan : zhong tu fang bian si xiang yan jiu = The interpretation of Kumãrajĩva's translation of Lotus Sutra : a study of the thought of Fang Bian in Chinese /." click here to view the abstract and table of contents click here to view the fulltext, 2005. http://net3.hkbu.edu.hk/~libres/cgi-bin/thesisab.pl?pdf=b18517274a.pdf.

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30

Battilana, Giusy. "YAP/TAZ transcriptional activity in triple negative breast cancer cells." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422762.

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YAP and TAZ are two closely related transcriptional regulators involved in tissue growth, stem cell maintenance and cancer. YAP/TAZ are aberrantly activated in different tumors where they have causative roles in initiation, progression and metastasis. However, the transcriptional program they activate in cancer cells remains incompletely understood. Therefore, we tried to dissect YAP/TAZ direct target genes in a breast cancer cell line (MDAMB-231 cells) by genome-wide analysis. In so doing, we discovered that YAP/TAZ mainly bind distal enhancers that contact target promoters through chromatin

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31

Citron, Anna. "Role of YAP/TAZ downstream of common oncogenic drivers." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425769.

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YAP and TAZ are transcriptional coactivators that play a central role in cancer initiation and growth. Despite being widespread activated in a number of human malignancies, YAP/TAZ aberrant triggering is rarely due to genetic alteration, but it is likely occurring as a consequence of mis-regulation of the complex network of signaling pathways that converge on these factors. We thus asked if recurrent oncogenic lesions, that are considered as tumorigenic drivers, might work though YAP/TAZ to induce cell transformation. We found that YAP/TAZ are not only activated upon oncogenic stimulation, but

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32

Sin, Kwok-wah Genious. "Genteel families of the Southern Dynasties with special reference to the Yanshi jiaxun = Cong "Yan shi jia xun" kan Nan Zhao shi zu de bian qian = /." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31685195.

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33

Lau, Shuk-yi. "A study of the border town by Shen Congwen and his other short novels Shen Congwen de "Bian cheng" ji qi ta xiao shuo yan jiu /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41005211.

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34

Chang, James C. P. "Taiwan's claim for nationhood : from Dr. Sun Yat-sen to President Chen Shui-bian - a theoretical treatise /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18439.pdf.

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35

APOLLONIO, MATTIA. "Regulation and function of tumor suppressor DAB2IP in the cellular response to mechanical inputs." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2996094.

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The crosstalk between tumor cells and their microenvironment is a major determinant of cancer progression. Thus, understanding and eventually interfering with the dynamic interplay between external cues and cellular responses may lead to more efficient chemotherapeutic approaches. The tumor suppressor DAB2IP encodes a RasGAP and cytoplasmic adaptor that controls specificity, amplitude, and duration of intracellular signaling events in response to multiple extracellular inputs such as inflammatory cytokines, growth factors and hormones. Accordingly, loss of DAB2IP function amplifies multiple on

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36

Yan, Sergey [Verfasser], Armin de [Akademischer Betreuer] Meijere, and Stefan [Akademischer Betreuer] Hell. "Photoaktivierungsfähige Rhodamine als Bio-Calcium-Sensoren und Markierungen für Tetracystein-Tags in Proteinen / Sergey Yan. Gutachter: Armin de Meijere ; Stefan Hell. Betreuer: Armin de Meijere." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2011. http://d-nb.info/1043936173/34.

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37

BERTINI, EFREM. "Yap is regulated by phosphorylation at the G2/M transition." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1192.

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La proteina umana Yap è un co-fattore trascrizionale ed è stata di recente oggetto di molti studi per la sua capacità di interagire con molti fattori di trascrizione. Questa capacità ha condotto molti ricercatori a fornire diverse interpretazioni sulla sua funzione, descrivendola sia come una proteina con attività onco-soppressiva, e sia come un fattore oncogenico. Inoltre, recenti studi hanno indicato un suo ruolo nella differenziazione cellulare e nella regolazione della dimensione di organi, in particolare del fegato. Tuttavia, il ruolo di questa proteina nella regolazione del ciclo cellula

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38

Wen, Liqiu. "Cong jie ji dou zheng dao jing ji gai ge : Zhongguo hun yin lun li de bian qian, 1949-1989 = From class struggle to economic reform : changes in the Chinese ethics of marriage, 1949-1989 /." click here to view the abstract and table of contents, 2003. http://net3.hkbu.edu.hk/~libres/cgi-bin/thesisab.pl?pdf=b17563434a.pdf.

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39

Wang, Jianjun. "He zuo de ke cheng bian ge zhong de jiao shi zhuan ye fa zhan Shanghai Shi "Xin ji chu jiao yu shi yan" ge an yan jiu = The professional development of teachers involved in collaborative curriculum change : the case of New Basic Education Project in Shanghai /." online access from Digital dissertation consortium, 2002. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?3066599.

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40

Chambeiron, Jérémie. "La cour constitutionnelle à Taïwan face aux différends institutionnels : le rôle des Grands Juges du Yuan judiciaire durant la présidence de Chen Shui-bian (2000-2008)." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015INAL0004/document.

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Le 18 mars 2000, Chen Shui-bian, représentant le Parti Démocrate-Progressiste (Minjindang) succédait à Lee Teng-hui, appartenant au Parti Nationaliste (Kuomintang), premier président élu au suffrage universel à Taïwan. Cependant, le Yuan législatif a connu à partir des années 2000, et jusqu'au terme du second mandat de Chen Shui-bian en 2008, de nombreux blocages, résultant du fait que le KMT et ses alliés du camp pan-bleu aient réussi à conserver à toutes les élections législatives le contrôle du parlement. Le point de départ de notre thèse est de comprendre comment ces blocages sont advenus,

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41

Zhuang, Qiuyu. "YAP/TAZ regulate autophagy to support epithelial plasticity and cancer stemness." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3426825.

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YAP and TAZ play a fundamental role in oncogenic transformation, organ development, stem cell amplification and regeneration during tissue damage. YAP and TAZ elicit their biological functions through the transcriptional regulation of downstream genes and effector pathways. We found that autophagy is modulated by YAP and TAZ. Given the central role of YAP and TAZ in mechanotransduction, we also confirmed that the mechanical cues control autophagy through YAP/TAZ. Importantly, autophagy control is integral to YAP/TAZ biology.<br>YAP e TAZ sono dei coattivatori trascrizionali che giocano un ruol

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STELITANO, DEBORA. "GTSE1: a novel TEAD4-E2F1 target gene involved in cell protrusions formation in Triple Negative Breast Cancer." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2908154.

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Dissemination of cancer cells from the primary tumors to distant organs represents the main cause of death in cancer patients. GTSE1 over-expression has been reported as a potential marker for metastasis in various types of malignancies including breast cancer where GTSE1 expression levels correlate with tumor grade, enhanced invasive potential and negative prognosis. Given the strong association between GTSE1 deregulation and bad clinical outcome the aim of this work was to clarify how GTSE1 is regulated in triple negative breast cancer and the molecular mechanism underlying GTSE1dependent c

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Castellan, Martina. "YAP/TAZ in the regulation of epidermal stem cell fate and glioblastoma cell behavior." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427144.

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Cells within a tissue respond to mechanical forces and changes in the physical properties of the external microenvironment; the two transcriptional regulators YAP and TAZ transduce these physical inputs into biological responses. In this scenario the epidermis is a point in case as it represents a real mechanosensitive tissue for its structure and functions. In the first part of this thesis, we showed that YAP/TAZ regulation by cell shape and rigidity of the extracellular matrix (ECM) controls the balance between proliferation and differentiation in epidermal SCs. Furthermore, we established a

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44

Sorrentino, Giovanni. "Metabolic control of YAP/TAZ by the Mevalonate Pathway." Doctoral thesis, Università degli studi di Trieste, 2014. http://hdl.handle.net/10077/10119.

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2012/2013<br>The YAP and TAZ mediators of the Hippo pathway (hereafter called YAP/TAZ) promote tissue proliferation and organ growth. However, how their biological properties intersect with cellular metabolism remains unexplained. Here, we show that YAP/TAZ activity is controlled by the SREBP/mevalonate pathway. Inhibition of the rate-limiting enzyme of this pathway (HMG-CoA reductase) by statins opposes YAP/TAZ nuclear localization and transcriptional responses. Mechanistically, the geranylgeranyl pyrophosphate produced by the mevalonate cascade is required for activation of Rho GTPases t

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45

Chow, Ka-kin Kelvin. "A study of the social status of the Canadian Chinese during the mid-twentieth century 20 shi ji zhong ye Jianada hua ren di wei zhuan bian zhi yan jiu /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B4163374X.

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46

Pocaterra, Arianna. "A novel genetic model to study mechanosignaling and its impact on YAP/TAZ activity in mammalian tissues." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3422296.

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Regulation of F-actin dynamics is key for multiple aspects of cell biology. Recent work indicates that this is particularly significant for cells to correctly sense the mechanical properties of the microenvironment, and to respond by regulating the YAP/TAZ transcriptional coactivators, which ultimately control cell behavior in response to mechanical cues. Yet, whether the connection between F-actin dynamics and YAP/TAZ signaling is physiologically relevant in mammalian tissues, and dominant over the pleiotropic effects of F-actin, remains unaddressed. We will present data on a novel mouse knoc

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47

Astone, Matteo. "A novel Yap/Taz zebrafish reporter reveals a role of Hippo pathway transducers in angiogenesis." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424650.

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YAP and TAZ, by orchestrating cell proliferation, cell death and cell-fate decisions, are key players of a complex network of signaling pathways acting during development. Deregulation of YAP/TAZ signaling causes robust organ overgrowth during organogenesis, which translates to loss of tissue homeostasis in the adult and consequent cancer development. YAP/TAZ are transcriptional co-activators that interact with TEAD transcription factors to promote cell proliferation and survival. Their transcriptional activity is regulated by nucleocytoplasmic shuttling and nuclear accumulation, which are con

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48

ROS, GLORIA. "ROLE OF HMGA1 IN BREAST CANCER AGGRESSIVENESS." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908068.

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Breast cancer is the most common cancer in women and a leading cause of cancer mortality worldwide, mainly due to metastatic progression. Although in the last years cancer has become more curable, the path to eradicate it, is still long and convolute. Understanding molecular mechanisms that induce and support cancer progression and aggressiveness is crucial to find new targets and drugs to treat it. High Mobility Group A1 (HMGA1) protein is an oncofetal architectural chromatin factor that promotes neoplastic transformation and progression but its role in breast cancer aggressiveness is still u

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49

Yang, Seung Ook. "Enzyme Encapsulation, Biosensing Endocrine Disrupting Chemicals, and Bio-therapeutic Expression Platforms Using Cell-Free Protein Synthesis." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6885.

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Cell-free protein synthesis (CFPS) is a powerful protein expression platform where protein synthesis machinery is borrowed from living organisms. Target proteins are synthesized in a reaction tube together with cell extract, amino acids, energy source, and DNA. This reaction is versatile, and dynamic optimizations of the reaction conditions can be performed. The "œopen" nature of CFPS makes it a compelling candidate for many technologies and applications. This dissertation reports new and innovative applications of CFPS including 1) enzyme encapsulation in a virus-like particle, 2) detection

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CROCI, OTTAVIO. "GENOMIC LANDSCAPE AND TRANSCRIPTIONAL REGULATION BY YAP AND MYC IN THE LIVER." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/556194.

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Abstract:

This thesis is divided in three sections; the main project is described in the first part, while additional projects are developed in two appendixes. In the main project we studied YAP, the downstream effector of the Hippo pathway, a transcriptional co-factor that plays a fundamental role in de-differentiation, cell proliferation and transformation. While its upstream regulation has been extensively studied, its role as transcriptional co-factor is still poorly understood. We show that YAP co-adjuvates the transcriptional responses of Myc oncogene to promote cell proliferation and transfor

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