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Journal articles on the topic 'Bifunctional compound'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Zaichenko, N. L., A. I. Shienok, L. S. Koltsova, et al. "Bifunctional photosensitive compound for optical processors." physica status solidi (c) 8, no. 9 (2011): 2746–48. http://dx.doi.org/10.1002/pssc.201084039.

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2

Chen, Katherine, Alice Jih, Sarah T. Kavaler, et al. "Dual actions of a novel bifunctional compound to lower glucose in mice with diet-induced insulin resistance." American Journal of Physiology-Endocrinology and Metabolism 309, no. 3 (2015): E293—E301. http://dx.doi.org/10.1152/ajpendo.00045.2015.

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Docosahexaenoic acid (DHA 22:6n-3) and salicylate are both known to exert anti-inflammatory effects. This study investigated the effects of a novel bifunctional drug compound consisting of DHA and salicylate linked together by a small molecule that is stable in plasma but hydrolyzed in the cytoplasm. The components of the bifunctional compound acted synergistically to reduce inflammation mediated via nuclear factor κB in cultured macrophages. Notably, oral administration of the bifunctional compound acted in two distinct ways to mitigate hyperglycemia in high-fat diet-induced insulin resistanc

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3

Yokochi, Hirogi, Rikito Takashima, Daisuke Aoki, and Hideyuki Otsuka. "Using the dynamic behavior of macrocyclic monomers with a bis(hindered amino)disulfide linker for the preparation of end-functionalized polymers." Polymer Chemistry 11, no. 21 (2020): 3557–63. http://dx.doi.org/10.1039/d0py00366b.

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End-functionalized polymers were synthesized by simply heating a mixture of a macrocyclic compound with one bis(2,2,6,6-tetramethylpiperidin-1-yl)disulfide (BiTEMPS) moiety and bifunctional acyclic BiTEMPS compounds as sources of repeat units and terminal groups, respectively.

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4

El-Gazzar, Marwa G., and Hala M. Aly. "Anticancer Evaluation and Docking Study of New Bifunctional Phthalazine Derivatives." Current Organic Synthesis 15, no. 3 (2018): 414–22. http://dx.doi.org/10.2174/2211556006666170927155809.

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Aims and Objective: A series of novel phthalazine derivatives was synthesized with versatile, readily accessible electrophilic and nucleophilic reagents. The newly synthesized compounds were confirmed by the results of spectroscopic measurements. Hence, their potential clinical application investigated in particular for cancer treatment. Materials and Methods: The newly synthesized compounds were characterized by spectroscopic measurements and were tested for their in vitro anticancer activity by MTT assay against human liver cancer cell line. Docking study of all the synthesized compounds was

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5

Ren, Tan, Guisheng Zhang, and Dexi Liu. "Synthesis of bifunctional cationic compound for gene delivery." Tetrahedron Letters 42, no. 6 (2001): 1007–10. http://dx.doi.org/10.1016/s0040-4039(00)02221-8.

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6

Choi, Dong Hoon, Sang Joon Oh, Hyo Bok Cha, and Joon Youl Lee. "Photochemically bifunctional epoxy compound containing a chalcone moiety." European Polymer Journal 37, no. 10 (2001): 1951–59. http://dx.doi.org/10.1016/s0014-3057(01)00102-1.

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7

Shiyonok, A. I., N. L. Zaichenko, L. S. Kol"tsova, and V. S. Marevtsev. "Photochemically bifunctional compound from the class of spironaphthooxazines." Russian Chemical Bulletin 52, no. 10 (2003): 2294–95. http://dx.doi.org/10.1023/b:rucb.0000011898.89321.85.

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8

Souard, Florence, Edwige Nicolle, Delphine Cressend, Alexis Valentin, and Ahcène Boumendjel. "Two in one: bifunctional derivatives of trolox acting as antimalarial and antioxidant agents." Future Medicinal Chemistry 12, no. 20 (2020): 1845–54. http://dx.doi.org/10.4155/fmc-2020-0106.

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Background: The aim of the present work was to set-up compounds that are able to act simultaneously as antimalarial and antioxidants. Trolox, a known antioxidant was chosen as a core structure to ensure the antioxidant activity and contribute to antiplasmodial effect. Results: Ten compounds were prepared in one step and evaluated on chloroquino-sensitive (3D7) and chloroquino-resistant (FcB1) strains of Plasmodium falciparum. The most active compound (3d) shows antiplasmodial activity in the range of chloroquine against chloroquino-sensitive and chloroquino-resistant P. falciparum strain. The

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9

Schulte, Marcus, and François P. Gabbaï. "Synthesis of heteronuclear bifunctional Lewis acids by transmetalation of 1,8-bis(trimethylstannyl)naphthalene with BCl3." Canadian Journal of Chemistry 80, no. 10 (2002): 1308–12. http://dx.doi.org/10.1139/v02-177.

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Reaction of 1,8-bis(trimethylstannyl)naphthalene (1) with an excess of BCl3 at 78°, followed by warming to 0°C, results in the exclusive formation of the novel bifunctional Lewis acid 1-(chlorodimethylstannyl)-8-(dichloroboryl)naphthalene (2), a compound in which a boryl and a stannyl moiety coexist at the peri-positions of a naphthalene core. At elevated temperature compound 2 undergoes a chloridemethyl exchange, which affords 1-(dichloromethylstannyl)-8-(chloromethylboryl)naphthalene (3). Compounds 2 and 3 have been characterized by multi-nuclear NMR spectroscopy. The single crystal X-ray

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10

Starnowska-Sokół, Joanna. "A hybrid for pain, i.e. bifunctional analgesics in neuropathy." BÓL 21, no. 4 (2021): 17–24. http://dx.doi.org/10.5604/01.3001.0014.8073.

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The need of developing new neuropathic pain therapies results from limited potency of currently available treatments, which is underlain by low efficacy of conventional analgesics, complex etiology and pathogenesis of neuropathy, diversity of its symptoms, as well as heightened side effects risk that accompanies the polypharmaceutical strategy, employed commonly to improve the therapeutic outcomes. Designing hybrid compounds, i.e. multimodal molecules that present the affinity to more than one receptor target, offers a promising perspective in this context. The multimodal approach allows to in

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11

Zhang, Chaofeng, Luiza M. F. Gomes, Tonglu Zhang та Tim Storr. "A small bifunctional chelator that modulates Aβ42 aggregation". Canadian Journal of Chemistry 96, № 1 (2018): 78–82. http://dx.doi.org/10.1139/cjc-2017-0623.

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Multifunctional compounds that can modulate amyloid-β (Aβ) aggregation and interact with metal ions hold considerable promise as therapeutic agents for Alzheimer’s disease (AD). Using the copper-catalyzed azide-alkyne cycloaddition reaction, a novel bifunctional chelator 2-(1-(4-(dimethylamino)benzyl)-1H-1,2,3-triazol-4-yl)phenol (L1) was synthesized. L1 contains a bidentate metal-binding unit and a pendant dimethylamino moiety. The product was characterized by 1H NMR, 13C NMR, and MS. The metal-binding properties of L1 were probed by UV–vis spectroscopy to determine Cu:L stoichiometry. L1 was

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12

Taran, Martine, and Bernard Delmond. "Obtention de nouveaux squelettes diterpéniques lors de l'isomérisation d'époxydes diterpéniques sur alumine active." Canadian Journal of Chemistry 66, no. 7 (1988): 1558–65. http://dx.doi.org/10.1139/v88-253.

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The isomerization of diterpene epoxides on active neutral alumina has established the existence of new rearrangements of the diterpene skeleton. Methyl 8,14β-epoxysandarcopimarate leads to bicyclic diterpene compounds by a Grob fragmentation, to derivatives of cleistanthane by a 1,2 migration of the vinyl substituent, as well as to one cycloditerpene compound. The 7,8 (or 8,9) derivatives of methyl isopimarate lead essentially to hydroxyolefins formed by a bifunctional acid–base mechanism at the alumina surface. [Journal translation]

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13

Koefoed, Line, Kyoko Shimizu, Steen Uttrup Pedersen, Kim Daasbjerg, Alexander Kuhn, and Dodzi Zigah. "One-step preparation of bifunctionalized surfaces by bipolar electrografting." RSC Advances 6, no. 5 (2016): 3882–87. http://dx.doi.org/10.1039/c5ra20156j.

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Bipolar electrochemistry (BPE) is used for the first time to graft molecular layers of different nature from a single bifunctional precursor compound simultaneously on the two opposite sides of a substrate.

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14

Regelsberger, G., C. Jakopitsch, P. G. Furtmüller, et al. "The role of distal tryptophan in the bifunctional activity of catalase-peroxidases." Biochemical Society Transactions 29, no. 2 (2001): 99–105. http://dx.doi.org/10.1042/bst0290099.

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Catalase-peroxidases are bifunctional peroxidases exhibiting an overwhelming catalase activity and a substantial peroxidase activity. Here we present a kinetic study of the formation and reduction of the key intermediate compound I by probing the role of the conserved tryptophan at the distal haem cavity site. Two wild-type proteins and three mutants of Synechocystis catalase-peroxidase (W122A and W122F) and Escherichia coli catalase-peroxidase (W105F) have been investigated by steady-state and stopped-flow spectroscopy. W122F and W122A completely lost their catalase activity whereas in W105F

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15

Piętka-Ottlik, Magdalena, Agnieszka Lewińska, Anna Jaromin, Anna Krasowska, and Kazimiera A. Wilk. "Antifungal organoselenium compound loaded nanoemulsions stabilized by bifunctional cationic surfactants." Colloids and Surfaces A: Physicochemical and Engineering Aspects 510 (December 2016): 53–62. http://dx.doi.org/10.1016/j.colsurfa.2016.07.062.

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16

Zhang, Chang Rui, Wen Peng Yan, and Mei Gong Fan. "Synthesis and photoreaction mechanism of a novel bifunctional photochromic compound." Chinese Chemical Letters 18, no. 5 (2007): 519–22. http://dx.doi.org/10.1016/j.cclet.2007.03.019.

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17

Zong, Ziao, Jing Wang, Yidong Bin, Yanliu Wu, and Guimei Huang. "A bifunctional fluorescent probe for sensing of Al3+ and H2S." Analytical Methods 13, no. 18 (2021): 2157–64. http://dx.doi.org/10.1039/d1ay00096a.

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Compound L was developed from salicylaldoxime and 4-aminobenzamide. L displayed AIE characteristics in the solid state due to a unique dimer formation by intermolecular hydrogen bonds. L could also act as a bifunctional fluorescence probe for Al<sup>3+</sup> and H<sub>2</sub>S.

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18

Kalistratova, Antonida V., Мaxim S. Oshchepkov, Maria S. Ivanova, et al. "Wheat (Triticum aestivum L.) Reaction to New Bifunctional Carbamate Compounds." Journal of Agricultural Science 13, no. 9 (2021): 36. http://dx.doi.org/10.5539/jas.v13n9p36.

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Extreme environmental conditions increase the risk of abiotic stresses in plants, which reduce productivity of land. The investigation and developmentof synthetic approach to new antistress compounds, increasing the resistance of plants to negative factors, are relevant to the present. The objective of this study was to synthesize and to test the effect of a series of new carbamate and oxamate plant growth regulators on early vegetation processes of wheat (Triticum aestivum L.). Three independent series of experiments were conducted using lipophilic compounds N-(2,4-Dimethylphenyl)-N&rsquo

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19

Mangione, P. Patrizia, Stéphanie Deroo, Stephan Ellmerich, et al. "Bifunctional crosslinking ligands for transthyretin." Open Biology 5, no. 9 (2015): 150105. http://dx.doi.org/10.1098/rsob.150105.

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Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease. Reduction in the abundance of amyloid fibril precursor proteins arrests amyloid deposition and halts disease progression in all forms of amyloidosis including TTR type. Our previous demonstration that circulating serum amyloid P component (SAP) is efficiently depleted by administration of a specific small molecule ligand compound, that non-covalent

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20

Narita, Hiroshi, Hiroshi Kinoshita, and Takeo Araki. "Radical block copolymerization by a novel bifunctional redox and azo compound." Journal of Polymer Science Part A: Polymer Chemistry 30, no. 2 (1992): 333–35. http://dx.doi.org/10.1002/pola.1992.080300219.

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21

Guo, Dong, Chih‐Ming Liang, Kuohsun Chiu, and Wei‐Kuang Wang. "Bifunctional Sr(II)‐terephthalate compound: gas adsorption and luminescence sensing properties." Zeitschrift für anorganische und allgemeine Chemie 647, no. 11 (2021): 1193–97. http://dx.doi.org/10.1002/zaac.202000447.

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22

Remcho, T. Parks, Sravanthi D. Guggilapu, Phillip Cruz, et al. "Regioisomerization of Antimalarial Drug WR99210 Explains the Inactivity of a Commercial Stock." Antimicrobial Agents and Chemotherapy 65, no. 1 (2020): e01385-20. http://dx.doi.org/10.1128/aac.01385-20.

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ABSTRACTWR99210, a former antimalarial drug candidate now widely used for the selection of Plasmodium transfectants, selectively targets the parasite’s dihydrofolate reductase thymidine synthase bifunctional enzyme (DHFR-TS) but not human DHFR, which is not fused with TS. Accordingly, WR99210 and plasmids expressing the human dhfr gene have become valued tools for the genetic modification of parasites in the laboratory. Concerns over the ineffectiveness of WR99210 from some sources encouraged us to investigate the biological and chemical differences of supplies from two different companies (co

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23

Bren, Vladimir A., Alexander D. Dubonosov, Oksana S. Popova, Yurii V. Revinskii, Karina S. Tikhomirova, and Vladimir I. Minkin. "Synthesis and Photo- and Ionochromic and Spectral-Luminescent Properties of 5-Phenylpyrazolidin-3-one Azomethine Imines." International Journal of Photoenergy 2018 (September 23, 2018): 1–7. http://dx.doi.org/10.1155/2018/9746534.

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Photochromic 5-phenylpyrazolidin-3-one-based azomethine imines containing 2-((1H-imidazol-2-yl)methylene) 1, 2-(pyridin-2-ylmethylene) 2, 2-(quinolin-2-ylmethylene) 3, and 2-((8-hydroxyquinolin-2-yl)methylene) 4 substituents were synthesized. All the compounds exist in the ring-opened O forms. Under irradiation with light of 365 nm, compounds 1–4 undergo thermally reversible isomerization into ring-closed bicyclic diaziridine isomers C. Azomethine imines 1–3 exhibit properties of ion-active molecular “off-on” switches of fluorescence when interacting with F− or AcO− anions. Compound 4 represen

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24

Lang, Heinrich, Michael Leise, and Wolfgang Imhof. "Selektive Additionsreaktionen an bifunktionalen neutralen Phosphenium-Ion-Komplexen / Selective Addition Reactions of Bifunctional Neutral Phosphenium Ion Complexes." Zeitschrift für Naturforschung B 46, no. 12 (1991): 1650–58. http://dx.doi.org/10.1515/znb-1991-1211.

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The reaction of bifunctional neutral phosphenium ion complexes, containing a carbon-carbon triple bond next to a phosphorus-molybdenum multiple bond, with carbenes and to carbene isolobal organometallic fragments is discussed.So, the reaction of (R)(PhC=C)P=MoCp′(CO), (R = 2,4,6-′Bu3C6H2O; Cp′ = η5-C5H5: la; Cp′ = η5-C5Me5: 1b) with CH2,Ν2 (2) yields the three membered heterocyclic compound (3). 3 reacts with Co2(CO)8 to afford complex (5) in which the phenylethynyl building block is η2-side-on coordinated to a Co2(CO)6 fragment. Similar to the reaction of 1 with 2, 1 forms with Fe2(CO)9 (6),

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25

Özbilen, Deniz, Bernhard Beile, and Herbert Meier. "Formation and Fragmentation of 4-Diazo-1,2-diphenyl-3-oxo-butyl Acetate." Zeitschrift für Naturforschung B 68, no. 1 (2013): 99–102. http://dx.doi.org/10.5560/znb.2013-2271.

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threo-4-Diazo-1,2-diphenyl-3-oxo-butyl acetate (15) could be prepared via the classical route 6→8→10→12→13→15. However, its alkaline hydrolysis to the bifunctional hydroxy compound 17 led to a spontaneous dehydration to the diazoketone (E)-18 and to a fragmentation to acetic acid, benzaldehyde (8) and diazoketone 19.

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26

Lee, Ah-Rang, and Won-Sik Han. "Incorporating two different chromophores onto a silicon atom: the crystal structure and photophysical properties of 9-{4-[(9,9-dimethyl-9H-fluoren-2-yl)dimethylsilyl]phenyl}-9H-carbazole." Acta Crystallographica Section C Structural Chemistry 71, no. 3 (2015): 195–98. http://dx.doi.org/10.1107/s2053229615002624.

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The crystal structure of the title bifunctional silicon-bridged compound, C35H31NSi, (I), has been determined. The compound crystallizes in the centrosymmetric space groupP21/c. In the crystal structure, the pairs of aryl rings in the two different chromophores,i.e.9-phenyl-9H-carbazole and 9,9-dimethyl-9H-fluorene, are positioned orthogonally. In the crystal packing, no classical hydrogen bonding is observed. UV–Vis absorption and fluorescence emission spectra show that the central Si atom successfully breaks the electronic conjugation between the two different chromophores, and this was furt

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27

Saragi, Tobat P. I., Robert Pudzich, Thomas Fuhrmann, and Josef Salbeck. "Organic phototransistor based on intramolecular charge transfer in a bifunctional spiro compound." Applied Physics Letters 84, no. 13 (2004): 2334–36. http://dx.doi.org/10.1063/1.1690110.

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28

Sharma, R. K., M. P. Dobhal, Y. P. Singh, et al. "Effects of Organoantimony(III) Compounds of Sterically Hindered Bifunctional Tetradentate Ligands on the Reproductive System of Male Rats." Metal-Based Drugs 7, no. 5 (2000): 271–74. http://dx.doi.org/10.1155/mbd.2000.271.

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The antifertility activity of organoantimony(III) complexes PhSb[RC(NC6H4S)CH2(NC6H4S)CR′] {R' = CH3 (R1) and R = R' = CF3 (R2)} derived from corresponding sterically hinlered bifuinctional tetradentate ligands in the male rats was determined. The administration of compounds R1 and R2 at the dose level of 20 mg/kg. b. wt. siignificantly reduced the weights of testes and epididymides. Auxiliary glands showed a significant reduction after the treatment of compound R1 only. Treated animals showed a notable depression of spermatogenesis. The preleptotene spermatocytes were decreased by 76.19 and 4

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29

Zhou, Caixia, Taotao Gao, Jiong Tan, Zhaozu Luo, Lutfy Mutallip, and Dan Xiao. "Synthesis of flower-like nickel–iron–chromium nanostructure compound deposited stainless steel foil as an efficient binder-free electrocatalyst for water splitting." Sustainable Energy & Fuels 5, no. 10 (2021): 2649–59. http://dx.doi.org/10.1039/d1se00002k.

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30

Kysil, Andrii, Angelina Biitseva, Tetyana Yegorova, Igor Levkov, and Zoia Voitenko. "Reaction of 1-aminoisoindole with methyl 4-chloro-3-oxobutanoate." French-Ukrainian Journal of Chemistry 6, no. 2 (2018): 32–37. http://dx.doi.org/10.17721/fujcv6i2p32-37.

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Condensation of bifunctional 1-aminoisoindole with bis-electrophilic methyl 4-chloro-3-oxobutanoate undergoes regioselectively to afford 2-(chloromethyl)-2-hydroxy-2,6-dihydropyrimido[2,1-a]isoindol-4(3H)-one. The structure of the reaction product was unambiguously established by HMQC and HMBC heteronuclear correlations. The functionalization of the synthesized compound by reactions with a series of aliphatic amines was carried out.

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31

Crosby, Ian T., Geoffrey A. Pietersz, and Justin A. Ripper. "Synthesis of Succinimidoalkylbenzaldehyde Analogues: Potential Bifunctional Linkers for Bioconjugation." Australian Journal of Chemistry 61, no. 2 (2008): 138. http://dx.doi.org/10.1071/ch07404.

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A series of novel 4-substituted benzaldehydes containing a succinimide moiety were synthesized as potential bifunctional linkers for the purpose of binding therapeutic drugs to antibodies raised against cancer cells. These potential benzaldehyde linkers varied in the nature of the para functionality so as to provide a range of potential acid labilities. Synthesis of the linkers involved a Williamson ether formation to make the ether linker 1, a Sonagoshira palladium-catalyzed coupling to synthesize the skeleton of the alkyl linker 2, and formation of an amide bond directly from a methyl ester

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32

Rucins, Martins, Pavels Dimitrijevs, Klavs Pajuste, et al. "Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines." Pharmaceutics 11, no. 3 (2019): 115. http://dx.doi.org/10.3390/pharmaceutics11030115.

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The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. These lipid-like 1,4-DHPs have been earlier proposed as promising n

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33

Yamane, Junji, Naoki Ohyabu, Min Yao, Hiroshi Takemoto, and Isao Tanaka. "In-crystal chemical ligation for lead compound generation." Journal of Applied Crystallography 43, no. 6 (2010): 1329–37. http://dx.doi.org/10.1107/s0021889810037222.

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A new fragment-based growth strategy for lead compound generation is proposed, which is based onin situchemical ligation and is operable in X-ray-based fragment screening format. The method involves two classes of bifunctional molecules, referred to as anchor molecules and tuning molecules. The anchor molecules are designed to form stable complexes with target proteins and to connect with the tuning molecules. The procedure begins with the introduction of the anchor molecule into the target protein, to which the tuning molecule is linked in the crystal. Proof-of-concept experiments using tryps

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34

Zhu, Ying-Gui, та Feng Gao. "catena-Poly[[diiodidomercury(II)]-μ-N,N′-p-phenylenebis(pyridine-3-carboxamide)-κ2 N:N′]". Acta Crystallographica Section E Structure Reports Online 63, № 3 (2007): m778—m779. http://dx.doi.org/10.1107/s160053680700709x.

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Crystals of the title compound, [HgI2(C18H14N4O2)] n , were obtained by the reaction of HgI2 and p-phenylene-bis(pyridine-3-carboxamide) in DMF. The asymmetric unit is composed of only half of the formula unit; the mercury atom lies on a crystallographic twofold rotation axis, and there is an inversion centre at the centre of the benzene ring. Each HgII atom is coordinated by two I atoms and two N atoms from two p-phenylene-bis(pyridine-3-carboxamide) (bpfb) ligands, in a distorted tetrahetral geometry. Bpfb acts as a bifunctional bridging ligand, linking HgII atoms into a one-dimensional chai

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35

Bai, Donglu. "Development of huperzine A and B for treatment of Alzheimer's disease." Pure and Applied Chemistry 79, no. 4 (2007): 469–79. http://dx.doi.org/10.1351/pac200779040469.

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Recent studies have proved that huperzine A (HupA) possesses different pharmacological actions other than the inhibition of hydrolysis of ACh. These noncholinergic roles, for instance, the antagonist effect on NMDA receptor, the protection of neuronal cells against β-amyloid, free radicals, and hypoxia-ischemia-induced injury, could be important too in Alzheimer's disease (AD) treatment. The therapeutic effects of HupA are probably based on a multitarget mechanism. By targeting dual active sites of AChE, a series of bis- and bifunctional HupB compounds with various lengths of tether were desig

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36

Lee, Jong-Young, Sung Min Kim, and Kwang-Jea Kim. "Observation of Interfacial Adhesion in Silica-NR Compound by Using Bifunctional Silane Coupling Agent." Polymer Korea 39, no. 2 (2015): 240–46. http://dx.doi.org/10.7317/pk.2015.39.2.240.

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37

Wang, Jianxin, Li Zhang, Lijie Zhao, Ting Li, and Shaobin Li. "A new polycatenated framework encapsulated Keggin-type silicotungstate crystalline compound with bifunctional electrochemical performances." Journal of Molecular Structure 1231 (May 2021): 129966. http://dx.doi.org/10.1016/j.molstruc.2021.129966.

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38

Havrylyk, O. P., Y. M. Andriichuk, V. M. Kushnir, and O. S. Liavynets. "Antioxidant properties of derivatives of 3,4-dihydropyrimidin-2-one with sterically hindered phenolic substituent in heterocycle." Chernivtsi University Scientific Herald. Chemistry, no. 818 (2019): 59–65. http://dx.doi.org/10.31861/chem-2019-818-08.

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In the processes of free-radical oxidation of organic compounds, the inhibitory action of the inhibitor is mainly due to either the breakdown of the reaction chains on its molecules, or the slowdown of the decomposition of intermediate hydroperoxides, or both at the same time. We analysed the inhibitory properties of 4-[3,5-di(tert-butyl)-4-hydroxyphenyl]-5-ethoxycarbonyl-6-methyl-3,4-dihydropyrimidin-2-one (I) and 4-[4-methoxyphenyl]-5-ethoxycarbonyl-6-methyl-3,4-dihydropyrimidin-2-one (II) gasometry and hydroperoxide decomposition methods. These compounds were obtained by the three-component

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39

Di Mola, Antonia, Maximilian Tiffner, Francesco Scorzelli, et al. "Bifunctional phase-transfer catalysis in the asymmetric synthesis of biologically active isoindolinones." Beilstein Journal of Organic Chemistry 11 (December 15, 2015): 2591–99. http://dx.doi.org/10.3762/bjoc.11.279.

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New bifunctional chiral ammonium salts were investigated in an asymmetric cascade synthesis of a key building block for a variety of biologically relevant isoindolinones. With this chiral compound in hand, the development of further transformations allowed for the synthesis of diverse derivatives of high pharmaceutical value, such as the Belliotti (S)-PD172938 and arylated analogues with hypnotic sedative activity, obtained in good overall total yield (50%) and high enantiomeric purity (95% ee). The synthetic routes developed herein are particularly convenient in comparison with the current me

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Massimine, Kristen M., Michael T. McIntosh, Lanxuan T. Doan, et al. "Eosin B as a Novel Antimalarial Agent for Drug-Resistant Plasmodium falciparum." Antimicrobial Agents and Chemotherapy 50, no. 9 (2006): 3132–41. http://dx.doi.org/10.1128/aac.00621-06.

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ABSTRACT 4′,5′-Dibromo-2′,7′-dinitrofluorescein, a red dye commonly referred to as eosin B, inhibits Toxoplasma gondii in both enzymatic and cell culture studies with a 50% inhibitory concentration (IC50) of 180 μM. As a non-active-site inhibitor of the bifunctional T. gondii dihydrofolate reductase-thymidylate synthase (DHFR-TS), eosin B offers a novel mechanism for inhibition of the parasitic folate biosynthesis pathway. In the present study, eosin B was further evaluated as a potential antiparasitic compound through in vitro and cell culture testing of its effects on Plasmodium falciparum.

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Berges, Peer, Volker Mansei, and Günter Klar. "Elementorganische Verbindungen mit o-Phenylenresten, XXIII [1] 2,3,6,9,10,13-Hexamethoxy-5,7,12,14-tetrathia-5,7,12,14-tetrahydropentacen - 2.3-Dichlor-5,6-dicyan-1,4-benzochinon (1/2) / Organometalloidal Compounds with o-Phenylene Substituents, XXIII [1] 2,3,6,9,10,13-Hexamethoxy-5,7,12,14-tetrathia-5,7,12,14-tetrahydropentacene - 2.3-Dichloro-5,6-dicyano-1,4-benzoquinone (1 /2)." Zeitschrift für Naturforschung B 47, no. 2 (1992): 211–16. http://dx.doi.org/10.1515/znb-1992-0212.

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The title compound is prepared by combining hot solutions of the components. X-ray analysis shows hexamethoxytetrathiatetrahydropentacene to act as a bifunctional donor, each of its dimethoxybis(organylthio)benzene units being in contact with a dichlorodicyanoquinone molecule. In the crystal stacks of the type DA2 ,DA2, ··· with an alternating arrangement o f donor and acceptor molecules are formed. In the complex the donor has a cis -conformation (boat form) in contrast to its pure form where the trans-conformation (chair form) is found.

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Ciubotaru, Mihai, Mihaela Georgiana Musat, Marius Surleac, et al. "The Design of New HIV-IN Tethered Bifunctional Inhibitors Using Multiple Microdomain Targeted Docking." Current Medicinal Chemistry 26, no. 15 (2019): 2574–600. http://dx.doi.org/10.2174/0929867325666180406114405.

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Currently, used antiretroviral HIV therapy drugs exclusively target critical groups in the enzymes essential for the viral life cycle. Increased mutagenesis of their genes changes these viral enzymes, which once mutated can evade therapeutic targeting, effects which confer drug resistance. To circumvent this, our review addresses a strategy to design and derive HIV-Integrase (HIV-IN) inhibitors which simultaneously target two IN functional domains, rendering it inactive even if the enzyme accumulates many mutations. First we review the enzymatic role of IN to insert the copied viral DNA into a

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De Rosa, Margherita, Anna Verdino, Annunziata Soriente, and Anna Marabotti. "The Odd Couple(s): An Overview of Beta-Lactam Antibiotics Bearing More Than One Pharmacophoric Group." International Journal of Molecular Sciences 22, no. 2 (2021): 617. http://dx.doi.org/10.3390/ijms22020617.

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β-lactam antibiotics are among the most important and widely used antimicrobials worldwide and are comprised of a large family of compounds, obtained by chemical modifications of the common scaffolds. Usually these modifications include the addition of active groups, but less frequently, molecules were synthesized in which either two β-lactam rings were joined to create a single bifunctional compound, or the azetidinone ring was joined to another antibiotic scaffold or another molecule with a different activity, in order to create a molecule bearing two different pharmacophoric functions. In t

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Ansarifar, A., R. Nijhawan, T. Nanapoolsin, and M. Song. "Reinforcing Effect of Silica and Silane Fillers on the Properties of Some Natural Rubber Vulcanizates." Rubber Chemistry and Technology 76, no. 5 (2003): 1290–310. http://dx.doi.org/10.5254/1.3547803.

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Abstract The reinforcing effect of up to 6 parts per hundred rubber by weight (phr) bis- (3-triethoxysilylpropyl) tetrasulfide (TESPT), a bifunctional organosilane, on the crosslink density, bound rubber, and technical properties of some conventional accelerator/sulfur compounds of natural rubber, containing 30 phr precipitated amorphous white silica was studied. The crosslink density and bound rubber improved as a function of TESPT loading. The tensile strength, elongation at break, stored energy density at rupture, and cohesive tear strength deteriorated at low loading of TESPT, but they sub

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De Rosa, Margherita, Anna Verdino, Annunziata Soriente, and Anna Marabotti. "The Odd Couple(s): An Overview of Beta-Lactam Antibiotics Bearing More Than One Pharmacophoric Group." International Journal of Molecular Sciences 22, no. 2 (2021): 617. http://dx.doi.org/10.3390/ijms22020617.

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β-lactam antibiotics are among the most important and widely used antimicrobials worldwide and are comprised of a large family of compounds, obtained by chemical modifications of the common scaffolds. Usually these modifications include the addition of active groups, but less frequently, molecules were synthesized in which either two β-lactam rings were joined to create a single bifunctional compound, or the azetidinone ring was joined to another antibiotic scaffold or another molecule with a different activity, in order to create a molecule bearing two different pharmacophoric functions. In t

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Kuranov, Sergey, Olga Luzina, Mikhail Khvostov, et al. "Bornyl Derivatives of p-(Benzyloxy)Phenylpropionic Acid: In Vivo Evaluation of Antidiabetic Activity." Pharmaceuticals 13, no. 11 (2020): 404. http://dx.doi.org/10.3390/ph13110404.

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A series of bornyl derivatives of p-(benzyloxy)phenylpropionic acid were prepared, and their hypoglycemic activities were examined by an oral glucose tolerance test in mice. The results of this test revealed two compounds, 1 and 3, that can reduce the blood level of glucose similarly to reference compound vildagliptin. Both compounds were tested in an experiment on mice with metabolic disorders: the C57BL/6Ay strain. Along with hypoglycemic properties, the two compounds showed different abilities to correct lipid metabolism disorders. In silico prediction revealed that the studied substances a

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Such, Justyna, Krzysztof Jóźwiak, and Artur Wnorowski. "(R,R′)-4′-methoxy-1-naphthylfenoterol as a new multi-target compound of antitumorigenic properties." Postępy Polskiej Medycyny i Farmacji 5 (June 26, 2017): 9–15. http://dx.doi.org/10.5604/01.3001.0011.6190.

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Targeted therapies are based on the use of compounds that inhibit a specific target molecule within the tissue of interest. The recent advances in the molecular etiology of cancer significantly shifted the therapeutic approach from nonspecific cytotoxic agents towards molecules directed either at individual receptors or acting simultaneously on multiple molecular targets. This article is an overview of recent literature on (R,R′)-4′-methoxy-1-naphthylfenoterol (MNF), a novel bifunctional ligand that activates β2 adrenergic receptor (β2AR) and blocks GPR55 receptor. These two activities are imp

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Preuss, Janina, Michael Hedrick, Eduard Sergienko, et al. "High-Throughput Screening for Small-Molecule Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase 6-Phosphogluconolactonase." Journal of Biomolecular Screening 17, no. 6 (2012): 738–51. http://dx.doi.org/10.1177/1087057112442382.

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Plasmodium falciparum causes severe malaria infections in millions of people every year. The parasite is developing resistance to the most common antimalarial drugs, which creates an urgent need for new therapeutics. A promising and attractive target for antimalarial drug design is the bifunctional enzyme glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (PfGluPho) of P. falciparum, which catalyzes the key step in the parasites’ pentose phosphate pathway. In this study, we describe the development of a high-throughput screening assay to identify small-molecule inhibitors of recombina

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Vivod, Vera, C. Q. Yang, and Bojana Voncina. "Non-Formaldehyde Polyfunctional Crosslinking System for Cotton." Advanced Materials Research 441 (January 2012): 5–9. http://dx.doi.org/10.4028/www.scientific.net/amr.441.5.

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Crosslinking of cotton with polycarboxylic acid, applied with catalysts based on phosphorus-containing inorganic acids, produces fabrics with excellent smooth-drying properties, which release no formaldehyde at any stage of preparation or on storage. If polycarboxylic acid has three or more carboxylic acid groups, the formation of such an anhydride can occur more than once and crosslinking of the cellulose molecule occurs. In our research work the use of an unsaturated bifunctional acid (maleic acid) and a phosphorus-containing inorganic compound (sodium hydroxyphosphinite) to obtain durable p

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Zhang, Qingwei, Guili Xu, Ya Bao, Minru Jiao, and Jianqi Li. "Design, Synthesis, and Biological Evaluation of Dual c-Met/HDAC Inhibitors Bearing 2-Aminopyrimidine Scaffold." Pharmaceutical Fronts 02, no. 02 (2020): e117-e123. http://dx.doi.org/10.1055/s-0040-1719162.

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AbstractA series of c-Met/histone deacetylase (HDAC) bifunctional inhibitors was designed and synthesized by merging pharmacophores of c-Met and HDAC inhibitors. Among them, the most potent compound, 2o, inhibited c-Met kinase and HDACs, with IC50 values of 9.0 and 31.6 nM, respectively, and showed efficient antiproliferative activities against both A549 and HCT-116 cancer cell lines with greater potency than an equimolar mixture of the respective inhibitors of the two enzymes: crizotinib and vorinostat (SAHA). Our study provided an efficient strategy for the discovery of multitargeted antitum

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