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Relevant bibliographies by topics / Biginelli reactions

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Journal articles

Academic literature on the topic 'Biginelli reactions'

Author: Grafiati

Published: 10 March 2023

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Journal articles on the topic "Biginelli reactions"

1

Heravi, Majid M., and Vahideh Zadsirjan. "Recent Advances in Biginelli-type Reactions." Current Organic Chemistry 24, no. 12 (2020): 1331–66. http://dx.doi.org/10.2174/1385272824999200616111228.

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The effective and high yielding synthesis of poly-functionalized pyrimidines, using multicomponent reactions (MCRs), is imperative in organic and medicinal chemistry. The classic Biginelli reaction is a typically one-pot three-component cyclocondensation reaction involving an aldehyde, a &#946;-ketoester and urea, resulting in the construction of multi-functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs). In recent years, other active methylene compounds, various derivatives of urea and diversely substituted aldehydes have also been used, resulting in the preparation of a new series of v

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2

Ma, Zeyu, Bo Wang, and Lei Tao. "Stepping Further from Coupling Tools: Development of Functional Polymers via the Biginelli Reaction." Molecules 27, no. 22 (2022): 7886. http://dx.doi.org/10.3390/molecules27227886.

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Multicomponent reactions (MCRs) have been used to prepare polymers with appealing functions. The Biginelli reaction, one of the oldest and most famous MCRs, has sparked new scientific discoveries in polymer chemistry since 2013. Recent years have seen the Biginelli reaction stepping further from simple coupling tools; for example, the functions of the Biginelli product 3,4-dihydropyrimidin-2(1H)-(thi)ones (DHPM(T)) have been gradually exploited to develop new functional polymers. In this mini-review, we mainly summarize the recent progress of using the Biginelli reaction to identify polymers f

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3

Tahmasbi, Marzieh, Nadiya Koukabi, and Ozra Armandpour. "Sono and nano: A perfect synergy for eco-compatible Biginelli reaction." Heterocyclic Communications 28, no. 1 (2022): 1–10. http://dx.doi.org/10.1515/hc-2022-0003.

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Abstract In this study, we evaluated the performance of nano-γ-Fe2O3–SO3H catalyst in the Biginelli reaction and synthesized 3,4-dihydropyrimidine-2-(1H)-ones. This reaction was carried out under solvent-free and ultrasonic irradiation conditions and belonged to one-pot multicomponent reactions (MCRs) with an adopted aromatic aldehyde, ethyl acetoacetate, and urea as starting materials for the beginning of the reaction. The synthesized materials were efficient in synthesizing 3,4-dihydropyrimidine-2-(1H)-ones via the Biginelli reaction under reaction conditions. Thus, the advantages of using n

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4

Krishna, Thalishetti, Eppakayala Laxminarayana, and Dipak Kalita. "FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction." European Journal of Chemistry 11, no. 3 (2020): 206–12. http://dx.doi.org/10.5155/eurjchem.11.3.206-212.1992.

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A facile and highly efficient FeF3-catalyzed method has been developed for the direct synthesis of functionalized dihydropyrimidines from readily available starting materials via Biginelli reaction. These reactions proceed at low-catalyst loadings with high functional group tolerance under mild conditions. This method provides efficient reusability of the catalyst and good to excellent yields of the products, making the protocol more attractive, economical, and environmentally benign. FeF3 is an attractive catalyst for the Biginelli reaction because of its high acidity, thermal stability and w

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5

Safari, Javad, Soheila Gandomi-Ravandi, and Samira Ashiri. "Organosilane sulfonated graphene oxide in the Biginelli and Biginelli-like reactions." New Journal of Chemistry 40, no. 1 (2016): 512–20. http://dx.doi.org/10.1039/c5nj01741f.

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6

Sánchez-Sancho, Francisco, Marcos Escolano, Daniel Gaviña, et al. "Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions." Pharmaceuticals 15, no. 8 (2022): 948. http://dx.doi.org/10.3390/ph15080948.

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The interest in 3,4-dihydropyrimidine-2(1H)-(thio)ones is increasing every day, mainly due to their paramount biological relevance. The Biginelli reaction is the classical approach to reaching these scaffolds, although the product diversity suffers from some limitations. In order to overcome these restrictions, two main approaches have been devised. The first one involves the modification of the conventional components of the Biginelli reaction and the second one refers to the postmodification of the Biginelli products. Both strategies have been extensively revised in this manuscript. Regardin

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7

Boukis, Andreas C., Baptiste Monney, and Michael A. R. Meier. "Synthesis of structurally diverse 3,4-dihydropyrimidin-2(1H)-ones via sequential Biginelli and Passerini reactions." Beilstein Journal of Organic Chemistry 13 (January 9, 2017): 54–62. http://dx.doi.org/10.3762/bjoc.13.7.

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The Biginelli reaction was combined with the Passerini reaction for the first time in a sequential multicomponent tandem reaction approach. After evaluation of all possible linker components and a suitable solvent system, highly functionalized dihydropyrimidone–α-acyloxycarboxamide compounds were obtained in good to excellent yields. In a first reaction step, different 3,4-dihydropyrimidin-2(1H)-one acids were synthesized, isolated and fully characterized. These products were subsequently used in a Passerini reaction utilizing a dichloromethane/dimethyl sulfoxide solvent mixture. By variation

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8

Hu, Xiaoyun, Jianxin Guo, Cui Wang, Rui Zhang, and Victor Borovkov. "Stereoselective Biginelli-like reaction catalyzed by a chiral phosphoric acid bearing two hydroxy groups." Beilstein Journal of Organic Chemistry 16 (July 31, 2020): 1875–80. http://dx.doi.org/10.3762/bjoc.16.155.

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To develop new efficient stereoselective catalysts for Biginelli-like reactions, a chiral phosphoric acid bearing two hydroxy groups derived from ʟ-tartaric acid was successfully synthesized via highly regioselective transformations of enantiopure 1,1,4,4-tetraphenylbutanetetraol. The obtained catalyst effectively catalyzed Biginelli-like reactions with moderate to good enantioselectivities. Control experiments indicated that the presence of the two hydroxy groups were indispensable for achieving a high enantioselectivity.

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9

Khaskel, Anamika, Pranjit Barman, Subir Kumar Maiti, and Utpal Jana. "Nebivolol nanoparticles: a first catalytic use in Biginelli and Biginelli-like reactions." Canadian Journal of Chemistry 96, no. 12 (2018): 1021–25. http://dx.doi.org/10.1139/cjc-2017-0621.

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Herein, we report the catalytic activity of nebivolol nanoparticles a novel organocatalyst for the synthesis of DHPMs and DHPM-5-carboxamides. The nanoparticles are confirmed by DSC, TEM, AFM, and IR spectroscopy. The catalyst can be readily recovered and reused for the next four runs without any significant impact on the yields of the products. The products are fully characterized by FTIR, 1H NMR, 13C NMR, and distortionless enhanced polarization transfer (DEPT) NMR. The methodology adopted here offers several advantages such as solvent-free reaction, low loading of catalyst, short reaction t

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10

Dallinger, Doris, A. Stadler, and C. O. Kappe. "Solid- and solution-phase synthesis of bioactive dihydropyrimidines." Pure and Applied Chemistry 76, no. 5 (2004): 1017–24. http://dx.doi.org/10.1351/pac200476051017.

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With the emergence of high-throughput screening in the pharmaceutical industry over a decade ago, synthetic chemists were faced with the challenge of preparing large collections of molecules to satisfy the demand for new screening compounds. The unique exploratory power of multicomponent reactions such as the Biginelli three-component reaction was soon recognized to be extremely valuable to produce compound libraries in a time- and cost-effective manner. The present review summarizes synthetic advances from our laboratories for the construction of Biginelli libraries via solution-and solid-pha

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