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Journal articles on the topic 'Bilayer formulation'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Pallavi, T., G. S. Sharma, B. Rama, L. Jyothi Rani, and B. Rajkamal. "Formulation and evaluation of floating bilayer tablets of epleronone." World Journal of Pharmaceutical Sciences 10, no. 04 (2022): 08–17. http://dx.doi.org/10.54037/wjps.2022.100402.

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Gastro retentive drug delivery systems have been widely used to prolong retention of dosage forms in stomach. Among the various approaches, the floating bilayer tablets formulation offers sustained drug release as well as prolonged gastric retention, along with the added advantage of liquid oral dosage form. The present study was an attempt to formulate and evaluate floating bilayer tablets of Epleronone by using various polymers like guar gum, ethyl cellulose, SSG, CCS. The prepared floating Bilayered tablets were evaluated for hardness, Weight variation, thickness, friability, drug content u

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2

Jangid, Vikash, Arindam Chatterjee, Saurabh Pandey, Vikash Agarwal, and Deeksha Sharma. "Formulation and Evaluation of Bi-Layer Tablet of Nebivolol and Nateglinide." Journal of Biomedical and Pharmaceutical Research 12, no. 3 (2023): 34–42. http://dx.doi.org/10.32553/jbpr.v12i3.993.

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In the present work, the Bilayered matrix type tablet were prepared by direct and wet granulation technique, in which immediate release layer ( by direct compression) contains Nebivolol and extended release layer (by wet granulation) contains Nateglinide. All the developed bilayer tablets were evaluated for weight variation, friability, thickness and hardness. The percent deviation from the average weight, friability, thickness and hardness was found to be within the prescribed official limits. Release profile of Nebivolol from formulations indicate that lower MCC (Formulations CF1 and CF3) an

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3

Gandhi, Kunjan, Sunil Kumar Shah, C. K. Tyagi, Prabhakar Budholiya, and Harish Pandey. "Formulation, Development and Evaluation of Uncoated Bilayer Tablet of Anti-Hypertensive Agents." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 100–107. http://dx.doi.org/10.22270/jddt.v10i4-s.4229.

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The present research work was carried out to Formulate and evaluation of bilayer tablet dosage form for the treatment of Hypertension.The objective of this study to compare the specific characteristics of Metoprolol [beta selective (cardio selective) adrenoreceptor blocking agent] and Hydrochlorothiazide (Thiazide Diuretics]) in order to design stable formulation. It can be concluded that bilayer tablet were successfully formulated to achieve immediate release of Hydrochlorothiazide (HCTZ) and tailored release of Metoprolol (MPL)by using Dual Release Drug Absorption System(DUREDAS technology).

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Saha, Shreya, Mithun Bhowmick, and Rimpa Goswami. "Bilayer Tablet: Novel Technology Use in Extended Release Drug Delivery System." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 962–65. http://dx.doi.org/10.22270/jddt.v9i3-s.2877.

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Bilayer tablet is a successful technology of controlled release formulation or extended release formulation to provide successful drug delivery. The name of this development is clear that the tablets have been consisting of two layers, these are immediate release layer (IR) and another is extended release layer (ER). In this era it is very useful in many developing countries as a combination therapy for various disease treatment purposes. Bilayer tablet are needs to separate incompatible active pharmaceutical ingredients (API) by physical separation. In this formulation IR and ER both layers a

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5

K, Kulkarni, and Deokar G. "From Challenges to Advancement for Bilayer Tablet Technology as Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1676–82. https://doi.org/10.25258/ijddt.14.4.64.

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Bilayer tablet technology is in focus because it advantageous for combination therapy, for combining two different release profile and it gives patent novelty to existing dosage. Hence its advantages, challenges and applications need to be discuss. The objective of preparing a review article on bilayer tablets is multifaceted, aiming to cover challenges at formulation development to scaleup and opportunity for new product development by integrating it bilayer tablet technology with other formulation technology. With reference to all the electronic data it was found that bilayer tablets face ma

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6

Reddy, K. Srinivasa, D. Vinay Kumar, CH Lakshmi Bharath, and P. Sri Ramya Madhuri. "FORMULATION AND EVALUATION OF SUMATRIPTAN SUCCINATE AND NAPROXEN SODIUM GASTRORETENTIVE (FLOATING) BILAYERED TABLETS." INDIAN DRUGS 57, no. 10 (2021): 30–41. http://dx.doi.org/10.53879/id.57.10.12196.

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The main aim of the present work was to formulate and evaluate sumatriptan succinate and naproxen sodium gastro retentive(floating) bilayered tablets. Floating bilayer tablets were formulated using direct compression method, it consist of two layers i.e IR layer containing Naproxen and floating CR layer containing sumatriptan. IR2 layer containing 2% concentration of Cross Povidone was found to be optimum and released 99.23% of naproxen in 45min. The optimized floating CR8 layer containing HPMC K 100M in 46% concentration showed 81.21% of drug release at the end of 12h. Among all formulations,

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7

Jamshiya.E*, and Anju.P. "FORMULATION, EVALUATION AND OPTIMIZATION OF FLOATING MATRIX TABLETS OF CARVEDILOL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 1146–58. https://doi.org/10.5281/zenodo.1188894.

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Bilayer floating tablets were prepared by direct compression using HPMC K100M and Ethyl cellulose as the release controlling polymers and sodium bicarbonate as a gas generating agent. The optimum concentrations of the above ingredients were determined under experimental conditions and on the basis of trial batches of the tablets. In the present study bilayer tablet was prepared manually using single station punching machine. Accurately weighed 150mg of sustained release layer powder mixture was fed manually into die cavity. Sustained release layer was compressed at mild compression force (2-3

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8

Subhash Tarate, Mr Vivek, and Dr Jagdishchandra Pati. "A Study on Bilayer Tablets for the Anti-Allergic Drug." Journal of Drug Discovery and Therapeutics 11, no. 2 (2023): 29–39. http://dx.doi.org/10.32553/jddt.v11i2.462.

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The bilayer tablet formulations used for each individual layer should be compressible (i.e., the capacity of a material to undergo a reduction in volume as a result of an applied pressure) and compactable (i.e., the capacity of a powder to be transformed into tablets with strength during densification) on their own, i.e., they should show satisfactory reduction in volume and form mechanically sound and coherent solid bodies. A bigger contact area exists between the layers as a result of the increased surface roughness, which improves interlayer adhesion. Bilayer tablet characterisation in earl

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9

Yunus, Attar Arshan. "Formulation and Evaluation of Bilayer of Omeprazole Sustained release action." International Journal of Research Publication and Reviews 6, no. 5 (2025): 16491–98. https://doi.org/10.55248/gengpi.6.0525.19106.

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10

Arti, Parmar* Akanksha jagwani Toshiba Khanam Narendra Gehalot Vikas Jain. "COMPREHENSIVE REVIEW ON FORMULATION AND MANUFACTURING TECHNIQUES OF BILAYER TABLETS." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3117–21. https://doi.org/10.5281/zenodo.13316959.

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Bilayer tablets are an inventive and adaptable drug delivery device because they have two layers, each with a unique drug release profile. This review summarises the development, manufacturing processes, formulation strategies, and pharmaceutical uses of bilayer tablets. Carefully choosing formulation ingredients is essential to the effectiveness of these tablets, taking into account medication compatibility as well as the effects of formulation variables on stability and bioavailability. A range of manufacturing approaches are examined, emphasising their scalability and appropriateness for ce

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11

Prapti, Yadav *. Narendra Lariya. "FORMULATION AND EVALUATION OF NANOCARRIER DRUG DELIVERY SYSTEM FOR HYPERPIGMENTATION." Journal of Pharma Research 7, no. 1 (2018): 13–18. https://doi.org/10.5281/zenodo.1159012.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he study is focused to formulation and evaluation of nanocarrier drug delivery system for Hyperpigmentation. Aspasomes were use as a vesicle for drug delivery and Ascorbyl palmitate were explore as a bilayer vesicle forming material which formed vesicles in combination with cholesterol and Soya Phosphatidylcholine. Aspasomes were prepared by film hydration method followed by sonication in which aqueous drug solution was encapsulated in aqueous regions of bilayer. Differential scanning calorimetric data of Aspasomes dispersion an

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12

Arunkumar, Selvi, L. Srinivas, D. Satyavati, and C. Emmanuel. "Formulation and Evaluation of Bilayer Matrix Tablets of Nebivolol Hydrochloride and Valsartan." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 82–93. http://dx.doi.org/10.22270/jddt.v9i4-s.3257.

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The present study is an attempt to develop bilayer matrix tablets of Nebivolol Hydrochloride and Valsartan with immediate release for Nebivolol Hydrochloride and sustained release for Valsartan. Superdisintegrants such as sodium starch glycolate and Crosscarmellose sodium were evaluated for immediate release of Nebivolol Hydrochloride and polymers HPMC K100M and K4M for sustained release of Valsartan. Preformulation studies were performed prior to compression. The compressed bilayer tablets were evaluated for weight variation, thickness, hardness, friability, drug content and in vitro drug rel

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Dr.E, Hari Krishna T. Mallika *. DS Spandana M. Harika Raj S. Jyothi. "DEVELOPMENT AND EVALUATION OF METFORMIN HCL LOADED EUDRAGIT®RSPO AND EUDRAGIT®RLPO AND GLIMEPIRIDE BILAYER TABLETS." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3371–80. https://doi.org/10.5281/zenodo.1000995.

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The present study was carried out for developing the formulation of Bilayer tablets of Glimepiride, Metformin HCl. Immediate Release (IR) layer was compressed as direct compression method and Sustained Release (SR) layer blends were compressed by wet granulation method. IR and SR layers were evaluated for pre and post compression studies and all studies were found to be within limits. From dissolution data of Glimepiride Immediate release layer, IR5 formulation was shown maximum drug release at 60 min i.e., 96.4%. Hence IR5was concluded as optimised formulation for IR layer. Sustained layer co

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14

Niranjan, Abadhesh Kumar, and Alka Singh. "Formulation, Development and Evaluation of Bilayer Floating Tablets of Antihypertensive Drug Bosentan." Journal of Drug Delivery and Therapeutics 11, no. 6 (2021): 167–72. http://dx.doi.org/10.22270/jddt.v11i6.5113.

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Hypertension, or high blood pressure, is a major public health concern around the world because of its large contribution to the global health burden and its function as a major risk factor for a variety of disease processes. Bosentan SR Floating Bilayer Tablets were made with HPMC K4M, HPMC E-15, and HPMC E-15 alone (80%) and in combination with varying percentages of polymer (20&60 percent, 40&40 percent, and 60&20 percent ). The hydrophilic polymer HPMC is used to make three different formulations (M4, M8, and M12) of floating Bosentan SR tablets, each with a viscosity grade of

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15

Mangilal, Teelavath, and Shiva Kumar Y. "Formulation and In Vitro Evaluation of Bilayered Matrix Tablets of Pioglitazone for Immediate Release and Glimepiride for Extended Release." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 6 (2018): 4348–54. http://dx.doi.org/10.37285/ijpsn.2018.11.6.8.

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Bi-layer tablets are novel drug delivery systems where a combination of two or more drugs in a single unit having different release profiles which improves patient compliance and prolongs the drug action. The study was performed to design bilayer matrix tablets of pioglitazone for immediate release and glimepiride for extended release delivery system. Bilayered matrix tablets composed of two layers, one is immediate release and a second layer is extended release layers. The immediate release layer comprised sodium starch glycolate, and croscarmellose sodium as super disintegrates and extended

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16

Manish, Kumar Gupta, Ghadge Madhvi, Verma Sunil, and Singh Sudharshana. "FORMULATION AND EVALUATION OF BILAYER TABLETS FOR SUSTAINED RELEASE." International Journal of Current Pharmaceutical Review and Research 13, no. 3 (2021): 38–43. https://doi.org/10.5281/zenodo.12667170.

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Bi-layer tablet is a new era for successful development of controlled release formulationalong with various features to provide successful drug delivery. Bilayer layer tablets consistof two layers which are slow release and immediate release layers. It is an improvedtechnology to overcome the shortcoming of the single layer tablets and offer more benefits.The bilayer tablet helps to separate incompatible active pharmaceutical ingredient (APIs)from each other. Bilayer tablets material involves both the compressibility and consolidation.Bilayer formulations carry different drugs in each layer an

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17

Ansary, Wasim Akter, Priya Rani Paul, Md Salvin Morshed, Md Raihan Sarker, Md Abdur Rahim, and Md Shahadat Hossain. "Design and Formulation of Modified-Release Bilayer Tablets of Rosuvastatin and Ezetimibe." Bangladesh Pharmaceutical Journal 28, no. 1 (2025): 70–82. https://doi.org/10.3329/bpj.v28i1.79467.

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Cardiovascular disease (CVD) causes a significant number of morbidity and mortality worldwide, primarily driven by dyslipidemia and abnormal lipid levels. Effective management of hyperlipidemia and CVD typically involves using various pharmacological agents, including statins (like atorvastatin and rosuvastatin), cholesterol absorption inhibitors (like ezetimibe), and fibrates. The combined use of these agents has been shown to decrease cardiovascular events effectively over a long duration. This study formulated and designed a bilayer tablet containing sustained-release formulations of rosuva

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18

Journal, Devanshi, Dibya Kumari, and Umesh Kumar Jain. "Formulation and Evaluation of Gastroretentive Bilayer Tablets." Journal of Drug Delivery and Therapeutics 14, no. 9 (2024): 107–12. http://dx.doi.org/10.22270/jddt.v14i9.6784.

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Gastroretentive bilayer tablets were designed to prolong the gastric residence time after oral administration and to achieve immediate release of lansoprazole and controlled release floating layer of clarithromycin to treat gastric ulcers. Instant release layer has a combination of super disintegrating agents. A combination of effervescent mechanism is used. HPMC K5 was used as swelling polymer and citric acid, sodium bicarbonate as gas generating agent to reduce the floating lag time. Bilayer floating tablets were prepared with varying proportions of instant layer and sustained release floati

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Parashar, Tarun, and Nardev Singh. "FORMULATION AND IN VITRO EVALUATION OF BILAYER TABLET OF ATENOLOL FOR BIPHASIC DRUG RELEASE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 114. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.22975.

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Objective: In the present research work, the aim was to prepare the bilayer tablet of atenolol for biphasic drug release to improve its bioavailability and absorption in the lower gastrointestinal tract. Methods: In the formulation of immediate release crospovidone, croscarmellose sodium, and sodium starch glycolate was used as super disintegrate and was directly compressed. For a sustained release portion different grade hydroxypropyl methylcellulose (HPMC) K4M, HPMC K15M, gum tragacanth, gum acacia, guar gum, and ethyl cellulose. Preformulation studies were performed before compression. The

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20

Lodha, Gaurav S., and Satyam Z. Chemate. "Formulation and Evaluation of Teneligliptin and Telmisartan Bilayer Tablets for the Treatment of Coexistent Type II Diabetes Mellitus and Hypertension." Journal of Drug Delivery and Therapeutics 9, no. 5 (2019): 26–38. http://dx.doi.org/10.22270/jddt.v9i5.3537.

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In the current scenario type two diabetes mellitus and hypertension have become prevalent in large number of population. But there are many patients which are suffering from Type II Diabetes Mellitus as well as hypertension. Such condition is called co-existent Type II Diabetes Mellitus and Hypertension. In the present work an attempt is made to treat co-existent type II Diabetes Mellitus and hypertension by formulating a Bilayer tablet of Teneligliptin and Telmisartan. Both drugs are sustained released to give a day long relief to the patients and to also reduce the dose frequency. Both the l

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21

Prabu S, Lakshmana. "Formulation and Evaluation of Polymeric Bilayer Matrix Tablet Containing Glipizide and Metformin Hydrochloride." Bioequivalence & Bioavailability International Journal 4, no. 1 (2020): 1–11. http://dx.doi.org/10.23880/beba-16000139.

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The objective of the present study was to develop Bilayer tablets of Glipizide and metformin hydrochloride from polymeric matrices of HPMC K4M and Eudragit L-100. Drugs Glipizide and metformin hydrochloride are frontline anti-diabetic drugs prescribed in combination. Tablets were prepared by wet granulation method using different ratios of HPMC K4M and Eudragit L-100 and evaluated for its physicochemical properties, in vitro release profile and stability studies. The prepared granules physiochemical property results were within the limits and the formulated tablets hardness, friability and con

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22

Deokate, Ganesh, Deshmukh MT, and Shete RV. "Formulation and Evaluation of Antihypertensive Bilayer Tablet." American Journal of Pharmacy And Health Research 7, no. 8 (2019): 53–78. http://dx.doi.org/10.46624/ajphr.2019.v7.i8.006.

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D R, Nagesh, Jat Rakesh Kumar, and Ahmed Syed Mansoor. "FORMULATION AND DEVELOPMENT OF KETOPROFEN BILAYER TABLETS." International Journal of Drug Regulatory Affairs 5, no. 4 (2017): 26–32. http://dx.doi.org/10.22270/ijdra.v5i4.207.

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Dr., M. Sunitha Reddy* and Gadam Charitha. "FORMULATION AND IN-VITRO CHARACTERIZATION OF LOSARTAN POTASSIUM AND REPAGLINIDE BILAYER TABLETS." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2017): 4207–13. https://doi.org/10.5281/zenodo.1095022.

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The purpose of this study is to formulate and evaluate bilayer anti-hypertensive and anti-diabetic tablets. Bilayer tablet contains Losartan potassium for immediate release and Repaglinide for a sustained release. The bilayer tablets were prepared using crospovidone and sodium starch glycolate as super-disintegrants for the immediate release layer, hydroxyl propyl methyl cellulose K 100M and hydroxyl propyl methyl cellulose K 15M as polymers at various concentrations to retard the release of drug for a period of time. Immediate release layer was prepared by direct compression and wet granulati

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Palla, Sai Sowjanya, Rajkumar Kotha, Anusha Paladugu, E. Rajesh Kumar Reddy, Suryasri Lavanya Adavi, and K. Ramamohan Reddy. "Bilayer Floating Tablets for Gastroretentive Drug Delivery System." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 3 (2013): 2097–112. http://dx.doi.org/10.37285/ijpsn.2013.6.3.1.

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 Oral delivery of the drug is by far the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in the formulations but has a drawback of non-site specificity and short gastric resident time. In recent years, scientific and technological advancements have been made in the development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Among Several approaches of floating systems, Bilayer floating technology is considered as promising approa

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Arroyo-García, Carmen M., Daniela Quinteros, Santiago D. Palma та ін. "Synergistic Effect of Acetazolamide-(2-hydroxy)propyl β-Cyclodextrin in Timolol Liposomes for Decreasing and Prolonging Intraocular Pressure Levels". Pharmaceutics 13, № 12 (2021): 2010. http://dx.doi.org/10.3390/pharmaceutics13122010.

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The purpose of this study was to design, for the first time, a co-loaded liposomal formulation (CLL) for treatment of glaucoma including timolol maleate (TM) in the lipid bilayer and acetazolamide (Acz)-(2-hydroxy)propyl β-cyclodextrin (HPβCD) complexes (AczHP) solubilized in the aqueous core of liposomes. Formulations with TM (TM-L) and AczHP (AczHP-L), separately, were also prepared and characterized. A preliminary study comprising the Acz/HPβCD complexes and their interaction with cholesterol (a component of the lipid bilayer) was realized. Then, a screening study on formulation factors aff

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Parashar, Tarun, Kapil Kalra, Jyoti M. Kalra, et al. "Formulation and In-vitro Evaluation of Bilayer Tablet of Olmesartan Medoxomil for Biphasic Drug Release." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 02 (2023): 388–92. http://dx.doi.org/10.25258/ijpqa.14.2.24.

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Objective: The current study aimed to optimize the bioavailability and absorption of olmesartan in the lower gastrointestinal tract by creating a bilayer tablet for biphasic drug release. Methods: Microcrystalline cellulose was combined and direct compression the requirement for an early response to address an undesirable defect or condition. In the current instance, 5 mg of olmesartan must be released immediately, and the remaining 10 mg of olmesartan must be released gradually to maintain the therapeutic concentration. In order to adjust the release pattern of the olmesartan sustained releas

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S. Al-Lami, Mohammed. "Formulation and Evaluation of Sustained and Raft Forming Antacid Tablet." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 26, no. 1 (2017): 26–31. http://dx.doi.org/10.31351/vol26iss1pp26-31.

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Antacids have been widely used in the treatment of various gastric and duodenal disorders such as heartburn, reflux esophagitis, gastritis, irritable stomach, gastric and duodenal ulcers. A pH-responsive of bi-polymer of sodium alginate and pectin have been studied as raft-forming polymers using sodium bicarbonate and calcium carbonate as gas-generating and calcium ion sources. The aim of study was to formulate and evaluate mono and bilayer tablets of floating and sustained release antacid delivery systems using sodium carboxy methyl cellulose as a gel forming substance, calcium and magnesium

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Sikdar, KM Yasif Kayes, Ahad Ahamed, Md Mahbubul Alam, Md Raihan Sarkar, and BK Sajeeb. "Formulation and In-vitro Evaluation of Bilayer Tablets of Atenolol and Amlodipine." Bangladesh Pharmaceutical Journal 22, no. 2 (2019): 153–69. http://dx.doi.org/10.3329/bpj.v22i2.42299.

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The present investigation was focused on formulation and in-vitro evaluation of a fixed dose bilayer tablet of two prominent antihypertensive agents, atenolol and amlodipine. The tablets were designed to immediately release atenolol (ATF1-ATF5) by using different percentage of sodium starch glycolate as super-disintegrant for prompt blood pressure lowering activity and sustain release amlodipine (AMF1- AMF5) by varying the percentage of hydroxy propyl methylcellulose (HPMC) for prolonged activity. After evaluation of the physical and chemical parameters of the formulations according to United

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Gorde, V. D., Punit R. Rachh, Someshwar Mankar, Saurin Amin, and Prasad L. Gorde. "Formulation and development of bilayer tablet containing irbesartan and metformin hydrochloride for diabetic hypertensive patients." Journal of Applied Pharmaceutical Research 12, no. 4 (2024): 66–74. http://dx.doi.org/10.69857/joapr.v12i4.589.

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Background: Hypertension is a common complication of type II diabetes. The present research work aimed to develop bilayer tablets that would manage type II diabetes patients with hypertension. The prepared bilayer tablet has an immediate-release layer of anti-hypertensive irbesartan and a sustained-release (SR) layer of anti-diabetic metformin hydrochloride. The purpose of these bilayer tablets was to increase patient compliance by converting two separate monotherapy to single combination therapy. Methodology: Several ratios of polymers, including HPMC K100M, EC, Eudragit, and Guar gum, were e

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Aniket, Ravindra Pawar*, Bundela Ragini, and Karunakar Shukla Dr. "FORMULATION AND EVALUATION OF BILAYER TABLET OF NATEGLINIDE." World Journal of Pharmaceutical Science and Research 3, no. 6 (2024): 143–49. https://doi.org/10.5281/zenodo.14252787.

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The main objective of research work is to develop a bilayer tablet of Nateglinide, in which one layer is immediate layer for immediate action and second layer is the sustain release layer for maintaining the dose of the drug. Preformulation study was performing for various parameters like melting point, Bulk density, Tapped density. Carr’s index, Housner ratio etc. Bilayer tablets were prepared in two stages by using Crosspovidone different viscosity grades of hydroxy propyl methyl cellulose (HPMC) viz., K4M and K100M. The prepared Bilayer tablets were evaluated for hardness, bulk densit

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B, Vijaya Kumar, Prasad G, Ganesh B, Swathi C, Rashmi A, and Amarender Reddy G. "Development and Evaluation of Guaifenesin Bilayer Tablet." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 3 (2010): 1122–28. http://dx.doi.org/10.37285/ijpsn.2010.3.3.10.

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The objective of the present research was to develop a Bilayer tablet of guaifenesin (GBT) using superdisintegrant MCC and sodium starch glycolate for the fast release layer and metalose 90 SH and carbopol 934 for the sustaining layer. The guaifenesin SR granules of different formulation were evaluated for bulk density, tapped density, angle of repose, Carr’s index and Hausners ratio and results were found to be 0.460 ± 0.12 to 0.515 ± 0.03 gm/cm3 , 0.550 ±0.03 to 0.590 ±0.04 gm/cm3 , 19 ±0.01 to 26 ± 0.23, 13.72 ± 0.03 to 19.56 ± 0.04 & 1.137 to 1.196, respectively. The prepared bilayer t

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Harish Choodappa and Subramanian Somaskandan. "Formulation and evaluation of bilayer tablets: Glimepiride in floating drug delivery and Metformin in sustained release." International Journal of Research in Pharmaceutical Sciences 10, no. 3 (2019): 1602–7. http://dx.doi.org/10.26452/ijrps.v10i3.1319.

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In this study, we aimed to prepare bilayer tablets of Glimepiride in floating drug delivery and Metformin in sustained release formulation. Glimepiride is chosen in floating drug delivery to overcome the gastric irritation and gastric emptying time. Glimepiride was prepared by different polymers such as guar gum, xanthan gum, carbopol and sodium bicarbonate act as effervescent agent, and other excipients were mixed and compressed by direct compression as the first layer. Metformin was chosen in sustained release to reduce dose frequency using different polymer HPMC K100M, methylcellulose, PVP

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Tufail, Muhammad, Kifayat Ullah Shah, Ikram Ullah Khan, et al. "Controlled Release Bilayer Floating Effervescent and Noneffervescent Tablets Containing Levofloxacin and Famotidine." International Journal of Polymer Science 2024 (January 11, 2024): 1–12. http://dx.doi.org/10.1155/2024/1243321.

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The present study is aimed at designing bilayer-floating tablets to improve the drug concentration in the stomach for enhanced therapeutic efficacy. The tablets are comprised of an upper layer of levofloxacin (466.5 mg) and a lower layer of famotidine (133.5 mg). Five formulations (F1-F5) were developed by using hydroxypropyl methylcellulose grades (K4M, K15M, and K100M) along with Carbopol 934. In the case of the effervescent system (F1-F3), sodium bicarbonate was added to impart buoyancy to the tablets; while in the case of noneffervescent formulations (F4 & F5), guar gum and xanthan gum

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Kim, Namhyuck, Kyoungho Kim, Seungwei Jeong, et al. "Development and Evaluation of Bilayer Sustained-Release Tablets of Ruxolitinib Using Discriminative Pharmacokinetic Analysis and IVIVC." Pharmaceutics 17, no. 4 (2025): 432. https://doi.org/10.3390/pharmaceutics17040432.

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Objectives: This study explores the development and evaluation of a bilayer sustained-release (SR) tablet formulation of ruxolitinib. As a BCS Class 1 drug, ruxolitinib requires twice-daily dosing due to its short half-life. We designed a bilayer tablet that integrates immediate-release (IR) and SR components in varying ratios to achieve sustained plasma concentrations, which we evaluated using discriminative analysis. Methods: Bilayer tablets combining IR and SR components were prepared in different ratios. In vitro dissolution tests and pharmacokinetic studies were conducted using Beagle dog

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Umamaheswara Rao T, Smitha M, Maghiben M, and Damodara Velayudham A. "Analysis on the evaluation of aceclofenac bilayer tablets and its formulation using FT-IT method." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 323–28. http://dx.doi.org/10.26452/ijrps.v11ispl4.3798.

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The detached of the current research progress a bilayer tablet of aceclofenac utilizing sodium starch glycolate (SSG) and croscarmellose sodium (CCS) as super disintegrants for the formulation of immediate-release layer whereas polymers such as methocel K15M, Lubrizol 971P were utilized by the formulation of sustaining layer. The tablets were equipped by straight density technique. The organized tablets were estimated for pre-compressed parameters like micromeritic properties and post compressed parameters like bulk variation, aceclofenac satisfied and in-vitro dissolution studies. The in-vitr

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Mahata, Jaydip, Jeevan Patel, Ramakant Sharma, and Rakesh Patel. "Formulation and Evaluation of Bilayer Tablet of Saxagliptin." International Journal of Pharmaceutical Sciences and Medicine 7, no. 5 (2022): 72–86. http://dx.doi.org/10.47760/ijpsm.2022.v07i05.007.

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In the present study Saxagliptin 60mg tablets have been formulated and developed using direct compression and dry granulation technique, to provide a safe, highly effective method for treating congestive heart failure, edema and kidney disorder, while reducing undesirable adverse effects. Pre and post formulation parameters were studied for the formulated batches. The result of all the physical and in-vitro dissolution data concluded that bilayer tablet (I3,S9) was the most promising formulation. The trial conducted with the consecutive three batches for immediate release and sustained release

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Chandan, Singh* Rita Saini Shivanand Patil. "A Review of Bilayer Tablet Technology Immediate and Extended-Release Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4491–503. https://doi.org/10.5281/zenodo.15534239.

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Compared to monotherapy (traditional dosage forms), combination therapy is more common and has several benefits.  The best and most recent example of mixed dose formulation is bilayer tablet technology. The pharmaceutical industry has seen a rise in single-dose formulation that combines 2 or 3 molecules within the tablets. By lowering the number of dosages and increasing the bioavailability of dosage forms, it is well known for encouraging patient convenience and compliance.  Innovative variations of traditional oral drug delivery technologies are bilayer or multilayer tablets. The o

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Grilc, Blaž, and Odon Planinšek. "Evaluation of Monolayer and Bilayer Buccal Films Containing Metoclopramide." Pharmaceutics 16, no. 3 (2024): 354. http://dx.doi.org/10.3390/pharmaceutics16030354.

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The objective of this study was to develop buccal film formulations containing metoclopramide hydrochloride monohydrate (MCP) with and without a backing layer and to evaluate their release properties and physiochemical stability. The crystallization of MCP in the polymer matrix was monitored with image analysis techniques for rapid and scalable observation. The results showed that the addition of a protective layer and its thickness significantly affected the release rate and crystallization behavior of MCP in the formulations. The crystallization of MCP increased over time, and certain formul

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Tretiakova, Daria, Irina Le-Deigen, Natalia Onishchenko, Judith Kuntsche, Elena Kudryashova, and Elena Vodovozova. "Phosphatidylinositol Stabilizes Fluid-Phase Liposomes Loaded with a Melphalan Lipophilic Prodrug." Pharmaceutics 13, no. 4 (2021): 473. http://dx.doi.org/10.3390/pharmaceutics13040473.

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Previously, a liposomal formulation of a chemotherapeutic agent melphalan (Mlph) incorporated in a fluid lipid bilayer of natural phospholipids in the form of dioleoylglyceride ester (MlphDG) was developed and the antitumor effect was confirmed in mouse models. The formulation composed of egg phosphatidylcholine (ePC), soybean phosphatidylinositol (PI), and MlphDG (8:1:1, by mol) showed stability in human serum for at least 4–5 h. On the contrary, replacing PI with pegylation of the liposomes, promoted fast dissociation of the components from the bilayer. In this work, interactions of MlphDG-l

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Ashish, Sonawane* Yashpal More Vaibhav Patil. "Formulation And Assessment of Oral Gel for The Treatment of Mouth Ulcer Using Extract from Jamun Seed Powder." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3566–74. https://doi.org/10.5281/zenodo.15478930.

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A new era in the successful creation of controlled release formulations with many properties to offer an effective drug delivery mechanism began with the introduction of bilayer tablets. Bilayer tablets are superior to conventional mouthwash, sprays, and gels. Therefore, using a bilayer pill for analgesic and anti-inflammatory purposes is rather different. Two incompatible substances can be separated using bi-layer tablets, two treatments can be released successively, or sustained release tablets with an immediate release dose in the first layer and a maintenance dose in the second layer can b

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Choudhury, Priyanka, Pulak Deb, and Suvakanta Dash. "FORMULATION AND STATISTICAL OPTIMIZATION OF BILAYER SUBLINGUAL TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE AND AMBROXOL HYDROCHLORIDE." Asian Journal of Pharmaceutical and Clinical Research 9, no. 5 (2016): 228. http://dx.doi.org/10.22159/ajpcr.2016.v9i5.13343.

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ABSTRACTObjective: The aim of the present study is to formulate and optimize bilayer sublingual tablets of Levocetrizine hydrochloride and Ambroxolhydrochloride using a 2 response surface methodology employing design expert-10.0. Sodium starch glycolate and Camphor were selected asindependent variables while disintegration time (sec) and water absorption ratio (%) were considered as responses. 3Methods: The bilayer sublingual tablets were prepared by direct compression and evaluated for various evaluation parameters including hardness,thickness, friability, drug content uniformity, wetting tim

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Israr, Muhammad, Nicola Pugliese, Arshad Farid, et al. "Preparation and Characterization of Controlled-Release Floating Bilayer Tablets of Esomeprazole and Clarithromycin." Molecules 27, no. 10 (2022): 3242. http://dx.doi.org/10.3390/molecules27103242.

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Controlled-release effervescent floating bilayer tablets reduce dosage frequency and improve patient compliance with enhanced therapeutic outcomes. Generally, two different tablets of clarithromycin and esomeprazole, respectively, are given for the treatment of Helicobacter pylori infection and it might be worth incorporating both in a single tablet. In the current study, controlled-release floating bilayer tablets of clarithromycin and esomeprazole (F1–F4) were developed with different rates of polymeric materials by a direct compression method. During the formulation, Fourier-transform infra

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Sawant, Ganesh Shankar, Kiran Vilas Sutar, and Akhil S. Kanekar. "Liposome: A Novel Drug Delivery System." International Journal of Research and Review 8, no. 4 (2021): 252–68. http://dx.doi.org/10.52403/ijrr.20210433.

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Liposome is a spherical sac phospholipid molecule. It encloses a water droplet especially as form artificially to carry drug into tissue membrane. It is spherical sac vesicle it consists at least one lipid bilayer. Liposomes are mainly development for drug delivery size and size distribution. The process of sonication (extrusion) is required to obtain small size and narrow size distribution of liposome. The main significant role in formulating of potent drug, improve therapeutic effect. Liposome formulation is mainly design in increasing accumulation at the target site, and then resulting effe

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Kobanenko, Maria K., Daria S. Tretiakova, Ekaterina S. Shchegravina, et al. "Liposomal Formulation of a PLA2-Sensitive Phospholipid–Allocolchicinoid Conjugate: Stability and Activity Studies In Vitro." International Journal of Molecular Sciences 23, no. 3 (2022): 1034. http://dx.doi.org/10.3390/ijms23031034.

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To assess the stability and efficiency of liposomes carrying a phospholipase A2-sensitive phospholipid-allocolchicinoid conjugate (aC-PC) in the bilayer, egg phosphatidylcholine and 1-palmitoyl-2-oleoylphosphatidylglycerol-based formulations were tested in plasma protein binding, tubulin polymerization inhibition, and cytotoxicity assays. Liposomes L-aC-PC10 containing 10 mol. % aC-PC in the bilayer bound less plasma proteins and were more stable in 50% plasma within 4 h incubation, according to calcein release and FRET-based assays. Liposomes with 25 mol. % of the prodrug (L-aC-PC25) were cha

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Madhu, Rajak*, Amal Raj A., Singh Dhakad Rajendra, and Singh Rajput Hakim. "FORMULATION AND EVALUATION OF BILAYER TABLET OF ANTIHYPERTENSIVE DRUG." World Journal of Pharmaceutical Science and Research 3, no. 5 (2024): 440–53. https://doi.org/10.5281/zenodo.14050790.

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The aim of present study is to prepare bilayer tablets of Losartan Potassium with an immediate release and a sustained release layer. The immediate release layer was prepared using super disintegrant sodium starch glycolate and sustained release layer is formulated with different polymers. The bilayer tablets of losartan potassium were prepared by the direct compression method. The drug, polymers and other excipients used for both immediate (IR) and sustained release (SR) layers were passed through sieve #80 before their use in the formulation. The immediate dose of drug was calculated from to

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Das, Manoj Kr, Bhanu P. Sahu, and Jahan Nur Rahman Hazarika. "DEVELOPMENT OF BILAYER TABLETS FOR IMMEDIATE AND CONTROLLED RELEASE OF ALLICIN." International Journal of Current Pharmaceutical Research 9, no. 4 (2017): 153. http://dx.doi.org/10.22159/ijcpr.2017v9i4.20982.

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Objective: The purpose of this study was to develop and evaluate bilayer tablet for the immediate and controlled release of Allicin (Garlic Extract) for effective treatment of Hypertension.Methods: The immediate release layer was prepared by using super disintegrants-sodium starch glycolate and binder used xantham gum and the sustained release layer was prepared by using hydrophilic polymer like HPMC K 100 and PVP. Before preparation of the tablets, all the pre-formulation parameters were checked and the tablet of Allicin were prepared by direct compression method and was evaluated for physica

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Jung, Yeon-Gil, Brian R. Lawn, Mariusz Martyniuk, Han Huang, and Xiao Zhi Hu. "Evaluation of elastic modulus and hardness of thin films by nanoindentation." Journal of Materials Research 19, no. 10 (2004): 3076–80. http://dx.doi.org/10.1557/jmr.2004.0380.

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Simple equations are proposed for determining elastic modulus and hardness properties of thin films on substrates from nanoindentation experiments. An empirical formulation relates the modulus E and hardness H of the film/substrate bilayer to corresponding material properties of the constituent materials via a power-law relation. Geometrical dependence of E and H is wholly contained in the power-law exponents, expressed here as sigmoidal functions of indenter penetration relative to film thickness. The formulation may be inverted to enable deconvolution of film properties from data on the film

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M.Toma, Nawar, and Yehia I.Khalil. "Formulation and Evaluation of Bilayer Tablets Containing Immediate Release Aspirin Layer and Floating Clopidogrel Layer." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 22, no. 1 (2017): 40–49. http://dx.doi.org/10.31351/vol22iss1pp40-49.

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Aspirin and clopidogrel are considered the most important oral platelets aggregation inhibitors. So it is widely used for treatment and prophylaxis of cardiovascular and peripheral vascular diseases related to platelets aggregation .In this study aspirin and clopidogrel were formulated together as floating bilayer tablet system. Three different formulas of 75 mg aspirin were prepared by wet granulation method as immediate release layer; different disintegrants used to achieve rapid disintegration. Formula with crosscarmellose as disintegrant achieve rapid disintegration was selected for prepar

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Ganesh, Nayak1* Akshay Killekar2 Krishnananda Kamath K.1 A. R. Shabaraya1 Viresh Chandur1. "Formulation And Evaluation of a Bilayer Mucoadhesive Buccal Drug Delivery System for Carvedilol Nanoparticles." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 54–62. https://doi.org/10.5281/zenodo.14254155.

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The main objective of this study was to formulate carvedilol nanoparticles into mucoadhesive bilayer tablets and evaluate the nanoparticle-loaded formulation. This approach aims to address the challenges of low solubility, poor bioavailability, and first-pass metabolism associated with carvedilol when administered in conventional oral dosage forms. Carvedilol nanoparticles were prepared using the nanoprecipitation method, as described in Ganesh R. Nayak et al. (Int. J. of Pharm. Sci., 2024, Vol. 2, Issue 7, 2010-2018). Bilayer buccal tablets were then prepared by direct compression and evaluat

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