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Journal articles on the topic 'Bilayer Tablet'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Prof., Madhuri T. Deshmukh Ganesh Deokate *. Prof. R.V. Shete. "A REVIEW ON BILAYER TECHNOLOGY." Journal of Pharma Research 8, no. 3 (2019): 81–87. https://doi.org/10.5281/zenodo.2620324.

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<strong><em>ABSTRACT</em></strong> <strong><em>O</em></strong><em>ver the past 30 years, the expenses and complications involved in marketing new drug entities have increased with concomitant recognition of therapeutic advantages of controlled drug delivery. Now a days greater attention has been focused on development of controlled & immediate release drug delivery systems. Bi-layer tablet is suitable for sequential release of two drugs in combination and also for sustained release of tablet in which one layer is for immediate release as loading dose and second layer is maintenance dose. S

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2

K, Kulkarni, and Deokar G. "From Challenges to Advancement for Bilayer Tablet Technology as Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1676–82. https://doi.org/10.25258/ijddt.14.4.64.

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Bilayer tablet technology is in focus because it advantageous for combination therapy, for combining two different release profile and it gives patent novelty to existing dosage. Hence its advantages, challenges and applications need to be discuss. The objective of preparing a review article on bilayer tablets is multifaceted, aiming to cover challenges at formulation development to scaleup and opportunity for new product development by integrating it bilayer tablet technology with other formulation technology. With reference to all the electronic data it was found that bilayer tablets face ma

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Ashish, Sonawane* Yashpal More Vaibhav Patil. "Formulation And Assessment of Oral Gel for The Treatment of Mouth Ulcer Using Extract from Jamun Seed Powder." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3566–74. https://doi.org/10.5281/zenodo.15478930.

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A new era in the successful creation of controlled release formulations with many properties to offer an effective drug delivery mechanism began with the introduction of bilayer tablets. Bilayer tablets are superior to conventional mouthwash, sprays, and gels. Therefore, using a bilayer pill for analgesic and anti-inflammatory purposes is rather different. Two incompatible substances can be separated using bi-layer tablets, two treatments can be released successively, or sustained release tablets with an immediate release dose in the first layer and a maintenance dose in the second layer can b

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Inamdar, Irfan, and Syed Iftequar Ahmed. "Bilayer tablet overview: A revolutionary approach in sustained drug release & combination drug therapy." Journal of Innovations in Pharmaceutical and Biological Sciences 10, no. 02 (2024): 08–19. http://dx.doi.org/10.56511/jipbs.2023.10302.

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A fresh method of administering drug, the bilayer tablet is a single dosage form containing 2 or more Active Pharmaceutical Ingredients (API).By incorporating two distinct layers, bilayer tablets provide improved drug release profiles and enhanced therapeutic efficacy. This review's objective is to pinpoint the challengesthat arise when making bilayer tablets and to suggest solutions for these difficulties. To help you better grasp bilayer tablets, types like double side presses, single side presses, and bilayer tablet displacement presses are discussed along with their uses, advantages, and d

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NIZAMI, FARIDA, and YOGENDRA MALVIYA. "RECENT ADVANCEMENT AND CHALLENGES IN BILAYER TABLET TECHNOLOGY: AN OVERVIEW." Current Research in Pharmaceutical Sciences 11, no. 4 (2022): 91–97. http://dx.doi.org/10.24092/crps.2021.110401.

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Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermin

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Reddy M., Sunitha, and Lavanya Muppa. "A REVIEW OF CHALLENGES AND POSSIBILITIES OF BILAYER TABLET TECHNOLOGY." International Journal of Advanced Research 9, no. 08 (2021): 676–81. http://dx.doi.org/10.21474/ijar01/13315.

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Bilayer tablet making process involves certain challenges as well as advantages. Bilayer tablets are the prescriptions which comprise of two same or various medications consolidated in a solitary portion for viable treatment of the illness. Persistent consistence and cost measure are two significant boundaries in treatments. Bilayer tablets manage these focuses adequately. To deliver a decent quality bi-layer tablet, the apparatus should be built according to GMP. Different hardware are accessible to beat normal bi-layer issues, for example, layer detachment, lacking hardness, weight control,

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Gandhi, Kunjan, Sunil Kumar Shah, C. K. Tyagi, Prabhakar Budholiya, and Harish Pandey. "Formulation, Development and Evaluation of Uncoated Bilayer Tablet of Anti-Hypertensive Agents." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 100–107. http://dx.doi.org/10.22270/jddt.v10i4-s.4229.

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The present research work was carried out to Formulate and evaluation of bilayer tablet dosage form for the treatment of Hypertension.The objective of this study to compare the specific characteristics of Metoprolol [beta selective (cardio selective) adrenoreceptor blocking agent] and Hydrochlorothiazide (Thiazide Diuretics]) in order to design stable formulation. It can be concluded that bilayer tablet were successfully formulated to achieve immediate release of Hydrochlorothiazide (HCTZ) and tailored release of Metoprolol (MPL)by using Dual Release Drug Absorption System(DUREDAS technology).

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Singh, Abhay, Sudip Das, Sabnam Gupta, and Suman Ghosh. "The Challenges of Producing Bilayer Tablet: A Review." Journal of Drug Delivery and Therapeutics 11, no. 4-S (2021): 171–75. http://dx.doi.org/10.22270/jddt.v11i4-s.4922.

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Bilayer tablets are the advanced form of conventional immediate release tablet system, which consist of either two similar or different drugs combined in a single dose for effective treatment of the disease improving patient compliance. However, the multilayer tablet technology is demanding It also necessitates meticulous selection of excipients and manufacturing conditions for each technological stage. The aim of this review is to provide an outline of state of art of bilayer tablet technology and emphasise the difficulties experienced during Bilayer tablet manufacturing along with its intend

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9

BANSAL, MAYANK, and RAKESH GUPTA. "Bilayer Tablet a Dual Released, an Emerging Trend for Novel Drug Delivery System." Indian Journal of Health Care, Medical & Pharmacy Practice 4, no. 2 (2023): 46–70. http://dx.doi.org/10.59551/ijhmp/25832069/2023.4.2.50.

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Bilayer tablets are a kind of medication that effectively treats illness by combining two pharmaceuticals, either the same or different ones, in a single dosage. Physically separating active pharmaceutical ingredients (API) may prevent chemical incompatibilities, and bilayer tablets can pave the way for the creation of various drug release profiles, such as immediate and prolonged release. Analgesic and anti-inflammatory bilayer tablets are significantly different. Two medications may be sequentially released from a bi-layer tablet, making it ideal for sustained-release tablets. One layer can

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10

Gavali, Prashant* Gangurde Gayatri Dhum Manohar Sonawane Mitesh. "Development And Characterization of Bilayered Tablet of Paracetamol & Diclofenac Sodium." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1588–94. https://doi.org/10.5281/zenodo.15041971.

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By defining a bilayer tablet with a immediate release layer of paracetamol and a sustain release layer of diclofenac sodium, and by evaluating  their pre-compression and post-compression parameters, the primary goal of this research project is to create a steady detailing of a NASAID. A bilayer tablet consists of a moment layer for support discharge of diclofenac sodium and a layer for moment discharge of paracetamol. At that point, the bilayer tablet is planned by weighing all necessary fixings and following the coordinated compression strategy.  Using a USP disintegration device, t

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11

Subhash Tarate, Mr Vivek, and Dr Jagdishchandra Pati. "A Study on Bilayer Tablets for the Anti-Allergic Drug." Journal of Drug Discovery and Therapeutics 11, no. 2 (2023): 29–39. http://dx.doi.org/10.32553/jddt.v11i2.462.

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The bilayer tablet formulations used for each individual layer should be compressible (i.e., the capacity of a material to undergo a reduction in volume as a result of an applied pressure) and compactable (i.e., the capacity of a powder to be transformed into tablets with strength during densification) on their own, i.e., they should show satisfactory reduction in volume and form mechanically sound and coherent solid bodies. A bigger contact area exists between the layers as a result of the increased surface roughness, which improves interlayer adhesion. Bilayer tablet characterisation in earl

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12

Kim, Namhyuck, Kyoungho Kim, Seungwei Jeong, et al. "Development and Evaluation of Bilayer Sustained-Release Tablets of Ruxolitinib Using Discriminative Pharmacokinetic Analysis and IVIVC." Pharmaceutics 17, no. 4 (2025): 432. https://doi.org/10.3390/pharmaceutics17040432.

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Objectives: This study explores the development and evaluation of a bilayer sustained-release (SR) tablet formulation of ruxolitinib. As a BCS Class 1 drug, ruxolitinib requires twice-daily dosing due to its short half-life. We designed a bilayer tablet that integrates immediate-release (IR) and SR components in varying ratios to achieve sustained plasma concentrations, which we evaluated using discriminative analysis. Methods: Bilayer tablets combining IR and SR components were prepared in different ratios. In vitro dissolution tests and pharmacokinetic studies were conducted using Beagle dog

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13

Gangurde, Gayatri* Dhum Manohar Gavali Prashant Sonawane Mitesh. "Review on Bilayer Tablets." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1192–203. https://doi.org/10.5281/zenodo.15019244.

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Bi-layer tablets are essential for developing both immediate and modified drug delivery systems for various diseases. They facilitate controlled medication release, representing a significant advancement in Controlled Drug Delivery Systems (CDDS) and improving the effectiveness of medication delivery. Over the past 30 years, the complexity and costs of introducing new drugs have increased, leading to greater focus on sustained or controlled release systems. Bi-layer tablets enable precise delivery of medications with predetermined release profiles, preventing chemical incompatibilities between

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14

Akshay, Y. Sonawane Shubham S. Sonawane Jyoti Khapre. "Novel Approach And Current Applications Of Bilayer Tablet." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1491–504. https://doi.org/10.5281/zenodo.12788774.

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The bi-layer tablet represents a new era in the successful creation of controlled release formulations with numerous characteristics to ensure successful drug delivery. Bi-layer tablets may be the best solution for avoiding chemical incompatibilities across APIs by physical separation and for developing distinct medication release patterns. A bi-layer tablet is appropriate for the sequential release of two medications in combination, as well as for the sustained release of a tablet, with one layer for rapid release as a loading dosage and the second layer for maintenance dose. As a result, the

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15

Manish, Kumar Gupta, Ghadge Madhvi, Verma Sunil, and Singh Sudharshana. "FORMULATION AND EVALUATION OF BILAYER TABLETS FOR SUSTAINED RELEASE." International Journal of Current Pharmaceutical Review and Research 13, no. 3 (2021): 38–43. https://doi.org/10.5281/zenodo.12667170.

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Bi-layer tablet is a new era for successful development of controlled release formulationalong with various features to provide successful drug delivery. Bilayer layer tablets consistof two layers which are slow release and immediate release layers. It is an improvedtechnology to overcome the shortcoming of the single layer tablets and offer more benefits.The bilayer tablet helps to separate incompatible active pharmaceutical ingredient (APIs)from each other. Bilayer tablets material involves both the compressibility and consolidation.Bilayer formulations carry different drugs in each layer an

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16

Singh, Neha, Durga Pandey, Nilesh Jain, and Surendra Jain. "Formulation and In Vitro Evaluation of Bilayer Tablets of Lansoprazole and Amoxycillin Trihydrate for the Treatment of Peptic Ulcer." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 23–31. http://dx.doi.org/10.22270/jddt.v11i1.4481.

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The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lansoprazole in the immediate release layer and Amoxycillin in the sustained release layer, using sodium starch glycolate as a super disintegrant for the immediate release layer and the hydrophilic matrix HPMC K100M, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Bilayer tablet showed as initial burst effect to provide dose of immediate release layer Lansoprazole to control the acid secretion level and the sustained release of Amoxycillin for 24

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17

Saha, Shreya, Mithun Bhowmick, and Rimpa Goswami. "Bilayer Tablet: Novel Technology Use in Extended Release Drug Delivery System." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 962–65. http://dx.doi.org/10.22270/jddt.v9i3-s.2877.

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Bilayer tablet is a successful technology of controlled release formulation or extended release formulation to provide successful drug delivery. The name of this development is clear that the tablets have been consisting of two layers, these are immediate release layer (IR) and another is extended release layer (ER). In this era it is very useful in many developing countries as a combination therapy for various disease treatment purposes. Bilayer tablet are needs to separate incompatible active pharmaceutical ingredients (API) by physical separation. In this formulation IR and ER both layers a

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Amit, Pareek, and Kumar Gupta Mukesh. "An Overview of The Bilayer Tablet." International Journal of Current Pharmaceutical Review and Research 14, no. 04 (2022): 106–10. https://doi.org/10.5281/zenodo.12657682.

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In the history of the development of the controlled release formulation, the introductionof bilayer tablets marked the beginning of a new age. This innovation, in alongside otherfactors, has made it possible to successfully provide medications to the body. Through the useof physical separation, such as bilayer tablets, it is possible to prevent chemicalincompatibilities between API. Additionally, new pharmaceutical release patterns may bedeveloped. This article provides an overview of the most recent developments in thetechnology behind bilayer tablets, with a primary emphasis on the most sign

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Journal, Devanshi, Dibya Kumari, and Umesh Kumar Jain. "Formulation and Evaluation of Gastroretentive Bilayer Tablets." Journal of Drug Delivery and Therapeutics 14, no. 9 (2024): 107–12. http://dx.doi.org/10.22270/jddt.v14i9.6784.

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Gastroretentive bilayer tablets were designed to prolong the gastric residence time after oral administration and to achieve immediate release of lansoprazole and controlled release floating layer of clarithromycin to treat gastric ulcers. Instant release layer has a combination of super disintegrating agents. A combination of effervescent mechanism is used. HPMC K5 was used as swelling polymer and citric acid, sodium bicarbonate as gas generating agent to reduce the floating lag time. Bilayer floating tablets were prepared with varying proportions of instant layer and sustained release floati

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Palla, Sai Sowjanya, Rajkumar Kotha, Anusha Paladugu, E. Rajesh Kumar Reddy, Suryasri Lavanya Adavi, and K. Ramamohan Reddy. "Bilayer Floating Tablets for Gastroretentive Drug Delivery System." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 3 (2013): 2097–112. http://dx.doi.org/10.37285/ijpsn.2013.6.3.1.

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 Oral delivery of the drug is by far the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in the formulations but has a drawback of non-site specificity and short gastric resident time. In recent years, scientific and technological advancements have been made in the development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Among Several approaches of floating systems, Bilayer floating technology is considered as promising approa

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Amit, Pareek, and Kumar Gupta Mukesh. "An Overview of The Bilayer Tablet." International Journal of Current Pharmaceutical Review and Research 14, no. 4 (2022): 106–10. https://doi.org/10.5281/zenodo.7612899.

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In the history of the development of the controlled release formulation, the introduction of bilayer tablets marked the beginning of a new age. This innovation, in alongside other factors, has made it possible to successfully provide medications to the body. Through the use of physical separation, such as bilayer tablets, it is possible to prevent chemical incompatibilities between API. Additionally, new pharmaceutical release patterns may be developed. This article provides an overview of the most recent developments in the technology behind bilayer tablets, with a primary emph

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Soni, Nikita, Deepak Joshi, Vikas Jain, and Pradeep Pal. "A Review on Applications of Bilayer Tablet Technology for Drug Combinations." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 222–27. http://dx.doi.org/10.22270/jddt.v12i1.5206.

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Bilayer tablets are novel drug delivery systems where combination of two drugs in a single unit having different release profiles can be delivered. Bilayer tablets improve patient compliance, prolong the drug(s) action and can deliver two incompatible drugs in a single formulation. Bilayer tablets have one layer of active ingredient for immediate release and a second layer for delayed release, either as a second dose or in an extended release fashion. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. However, bilayer tablet technology i

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Mayur, Aware, Gondkar Sheetal, and Bachhav Rishikesh. "Bilayer Floating Tablet : A Novel Floating Tablet." International Journal in Pharmaceutical Sciences 1, no. 1 (2022): 86–93. https://doi.org/10.5281/zenodo.5895074.

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Out of various drug delivery system the novel drug delivery system is overcomes and then physiological problems of gastric retention by decreasing fluctuations in blood drug concentration level with consequent reduction in the undesirable toxicity and poor efficiency. Approaches have their been introduced to prolong gastric residence time such as the floating system, modified shape, swelling index, expanding system and high density system. Two layer floating drug delivery system is combined principle of bilayer tablet as well as floating mechanism. Bilayer floating tablet is new in the era for

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Padhan1, Ashutosh. "Bi-Layer Tablets for Controlled Release Drug Delivery." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 09, no. 02 (2025): 1–9. https://doi.org/10.55041/ijsrem41526.

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Bilayer tablets has the potential for successful combination therapy as novel drug delivery system. Bilayer tablets are modified release system in which one layer serves as loading dose and the other layer serves as maintenance dose to enhance the bioavailability or to avoid the interaction between the incompatible substances by separating them physically. Several The development of bi-layer tablets for a variety of reasons like patent extension, therapeutic, and marketing purposes. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. The

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Dr., M. Sunitha Reddy* and Gadam Charitha. "FORMULATION AND IN-VITRO CHARACTERIZATION OF LOSARTAN POTASSIUM AND REPAGLINIDE BILAYER TABLETS." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2017): 4207–13. https://doi.org/10.5281/zenodo.1095022.

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The purpose of this study is to formulate and evaluate bilayer anti-hypertensive and anti-diabetic tablets. Bilayer tablet contains Losartan potassium for immediate release and Repaglinide for a sustained release. The bilayer tablets were prepared using crospovidone and sodium starch glycolate as super-disintegrants for the immediate release layer, hydroxyl propyl methyl cellulose K 100M and hydroxyl propyl methyl cellulose K 15M as polymers at various concentrations to retard the release of drug for a period of time. Immediate release layer was prepared by direct compression and wet granulati

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M.Toma, Nawar, and Yehia I.Khalil. "Formulation and Evaluation of Bilayer Tablets Containing Immediate Release Aspirin Layer and Floating Clopidogrel Layer." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 22, no. 1 (2017): 40–49. http://dx.doi.org/10.31351/vol22iss1pp40-49.

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Aspirin and clopidogrel are considered the most important oral platelets aggregation inhibitors. So it is widely used for treatment and prophylaxis of cardiovascular and peripheral vascular diseases related to platelets aggregation .In this study aspirin and clopidogrel were formulated together as floating bilayer tablet system. Three different formulas of 75 mg aspirin were prepared by wet granulation method as immediate release layer; different disintegrants used to achieve rapid disintegration. Formula with crosscarmellose as disintegrant achieve rapid disintegration was selected for prepar

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Thakur, Sourav, Bhupendra Singh, Vijay Mishra, et al. "Bilayer Tablet Based Chronotherapeutics in the Management of Nocturnal Asthma: An Overview." Recent Patents on Drug Delivery & Formulation 13, no. 2 (2019): 74–82. http://dx.doi.org/10.2174/1872211313666190227204127.

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Background: Asthma is a common ailment with a larger circadian difference. Nocturnal Asthma (NA) is an inconstant exacerbation of asthmatic condition related to the rise in warning sign during the night time and there is a need for its treatment addressing air route alertness and decline in lung functions. These symptoms are linked to sleep or known as circadian events. Chronotherapeutics is a management system based on an in-vivo drug accessibility programmed to check the rhythms of ailment in a direction to improve the therapeutic outcomes by suppressing the side effects. This review aims to

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Khalid, Mohammad. ""Bi-Layer Tablets: Pioneering Novel Drug Delivery Systems"." International Journal for Research in Applied Science and Engineering Technology 12, no. 12 (2024): 1112–16. https://doi.org/10.22214/ijraset.2024.65979.

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In order to ensure regulated administration of various medications with predetermined release profiles, bi-layer tablets have been developed. The pharmaceutical industry has become more interested in creating a bilayer tablet, which combines two or more Active Pharmaceutical Ingredients (API), in a single dose form over the past ten years in an effort to improve patient convenience and compliance. Bi-layer tablets can be used for the sequential release of two medications together, to separate two substances that are incompatible, or for sustained release tablets where the first layer is an imm

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Sadhu, Venkateswara Rao, Priyanka Bopparaju, and Padmalatha Kantamneni. "Bilayer tablet technology: A novel approach." GSC Biological and Pharmaceutical Sciences 7, no. 2 (2019): 022–28. https://doi.org/10.5281/zenodo.4286145.

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Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second lay

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Swetanshu, ,., and Vijay Sharma. "Formulation, Optimization and Evaluation of Bilayer Tablet of Antihypertensive Drug." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 704–8. http://dx.doi.org/10.22270/jddt.v9i4.3098.

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Hypertension or high blood pressure occurs when the high cardiac output exerts pressure on the arterial wall as the blood flow increases. Bi-layer tablets are prepared with one layer of drug for immediate release while second layer designed to release drug later, either as second dose or in an extended release manner. Bi-layered tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances, and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is suitable f

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Gorde, V. D., Punit R. Rachh, Someshwar Mankar, Saurin Amin, and Prasad L. Gorde. "Formulation and development of bilayer tablet containing irbesartan and metformin hydrochloride for diabetic hypertensive patients." Journal of Applied Pharmaceutical Research 12, no. 4 (2024): 66–74. http://dx.doi.org/10.69857/joapr.v12i4.589.

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Background: Hypertension is a common complication of type II diabetes. The present research work aimed to develop bilayer tablets that would manage type II diabetes patients with hypertension. The prepared bilayer tablet has an immediate-release layer of anti-hypertensive irbesartan and a sustained-release (SR) layer of anti-diabetic metformin hydrochloride. The purpose of these bilayer tablets was to increase patient compliance by converting two separate monotherapy to single combination therapy. Methodology: Several ratios of polymers, including HPMC K100M, EC, Eudragit, and Guar gum, were e

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Chandan, Singh* Rita Saini Shivanand Patil. "A Review of Bilayer Tablet Technology Immediate and Extended-Release Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4491–503. https://doi.org/10.5281/zenodo.15534239.

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Compared to monotherapy (traditional dosage forms), combination therapy is more common and has several benefits.  The best and most recent example of mixed dose formulation is bilayer tablet technology. The pharmaceutical industry has seen a rise in single-dose formulation that combines 2 or 3 molecules within the tablets. By lowering the number of dosages and increasing the bioavailability of dosage forms, it is well known for encouraging patient convenience and compliance.  Innovative variations of traditional oral drug delivery technologies are bilayer or multilayer tablets. The o

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Israr, Muhammad, Nicola Pugliese, Arshad Farid, et al. "Preparation and Characterization of Controlled-Release Floating Bilayer Tablets of Esomeprazole and Clarithromycin." Molecules 27, no. 10 (2022): 3242. http://dx.doi.org/10.3390/molecules27103242.

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Controlled-release effervescent floating bilayer tablets reduce dosage frequency and improve patient compliance with enhanced therapeutic outcomes. Generally, two different tablets of clarithromycin and esomeprazole, respectively, are given for the treatment of Helicobacter pylori infection and it might be worth incorporating both in a single tablet. In the current study, controlled-release floating bilayer tablets of clarithromycin and esomeprazole (F1–F4) were developed with different rates of polymeric materials by a direct compression method. During the formulation, Fourier-transform infra

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Rajni, Dubey1 Saniya Mubarik*2 Bhaskar Kumar Gupta3 Mariya Beg1. "Formulation and Evaluation of By-Layered Tablet." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2848–95. https://doi.org/10.5281/zenodo.15101573.

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Several pharmaceutical companies are currently developing bi- layer tablets for a variety of reasons like patent extension, therapeutic efficacy, marketing etc. This technology has been used to reduce capital investment. Modified tablet presses have been used to develop bilayer tablets in order to overcome problems associated with tablets like layer separation, insufficient hardness, inaccurate individual layer weight control, cross contamination between the layers, reduce yield etc. When high production output is required a modified tablet, press is used.

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Ullah, Ghufran, Asif Nawaz, Muhammad Shahid Latif, et al. "Clarithromycin and Pantoprazole Gastro-Retentive Floating Bilayer Tablet for the Treatment of Helicobacter Pylori: Formulation and Characterization." Gels 9, no. 1 (2023): 43. http://dx.doi.org/10.3390/gels9010043.

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Bilayer/multilayer tablets have been introduced to formulate incompatible components for compound preparations, but they are now more commonly used to tailor drug release. This research aimed to formulate a novel gastro-retentive tablet to deliver a combination of a fixed dose of two drugs to eliminate Helicobacter pylori (H. pylori) in the gastrointestinal tract. The bilayer tablets were prepared by means of the direct compression technique. The controlled-release bilayer tablets were prepared using various hydrophilic swellable polymers (sodium alginate, chitosan, and HPMC-K15M) alone and in

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CHOURASIYA, ANJALI, NARENDRA GEHALOT, and SURESH CHANDRA MAHAJAN. "A REVIEW ON AN EMERGIN TREND BILAYER FLOATING DRUG DELIVERY SYSTEM." Current Research in Pharmaceutical Sciences 11, no. 2 (2021): 44–49. http://dx.doi.org/10.24092/crps.2021.110201.

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NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. Novel drug delivery system have been developed to overcome the limitation of conventional drug delivery systems, such as of gastric retention by decreasing fluctuations in the concentration of the drug in blood,resulting in the reduction in unwanted toxicity and poor efficiency. As compared to traditional dosage forms bilayer tablets are more efficient for sequential release of tw

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JARTOLIA, PRIYANKA, SAPNA AVINASH KONDALKAR, AVINASH KRISHNRAO KONDALKAR, and MURAREE LAL. "FORMULATION AND DEVELOPMENT OF BILAYER FLOATING TABLET OF AMOXICILLIN." Current Research in Pharmaceutical Sciences 10, no. 4 (2020): 76–89. http://dx.doi.org/10.24092/crps.2020.100403.

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Bilayer floating tablet of amoxicillin was formulated successfully and evaluated under suitable parameters. All the batches of tablet produced were found to exhibit short floating lag times. The tablet of batch F2 exhibited a longer floating lag time of 23 minutes. Relationship between the dependent and independent variables was further elucidated using contour and response surface plots. Dissolution profiles that the tablets of batch F3, F7, and F12 exhibits initial burst phase during the first hour of dissolution. The burst phase was followed by a limited drug release for the rest of the per

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Madhu, Rajak*, Amal Raj A., Singh Dhakad Rajendra, and Singh Rajput Hakim. "FORMULATION AND EVALUATION OF BILAYER TABLET OF ANTIHYPERTENSIVE DRUG." World Journal of Pharmaceutical Science and Research 3, no. 5 (2024): 440–53. https://doi.org/10.5281/zenodo.14050790.

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The aim of present study is to prepare bilayer tablets of Losartan Potassium with an immediate release and a sustained release layer. The immediate release layer was prepared using super disintegrant sodium starch glycolate and sustained release layer is formulated with different polymers. The bilayer tablets of losartan potassium were prepared by the direct compression method. The drug, polymers and other excipients used for both immediate (IR) and sustained release (SR) layers were passed through sieve #80 before their use in the formulation. The immediate dose of drug was calculated from to

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P, Pavazhaviji, and Rajalakshmi A. N. "FIXED-DOSE COMBINATION DRUGS AS TABLET IN TABLET: A REVIEW." International journal of multidisciplinary advanced scientific research and innovation 1, no. 9 (2021): 169–77. http://dx.doi.org/10.53633/ijmasri.2021.1.9.02.

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The Pharmaceutical industry has become more interested in developing fixed-dose combinations (FDCs) in recent years. FDCs have been used successfully in a variety of clinical areas, including diabetes, HIV/AIDS,and cardiovascular diseases etc. FDCs are intended to extend the product life cycle and enhance patient compliance by decreasing cost. Active Pharmaceutical ingredients are chosen for FDC development based on variety of purposes such as Pharmacokinetic profile, drug-drug interactions, mechanism of action, and manufacturability for successful development. Tablet in tablet technology has

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Huynh, Duyen Thi My, Son Thanh Khuu, Ly Ngoc Hanh, et al. "Batch Scale-Up and Impact of Process Parameters on Blend Homogeneity in Production of Bilayer Film-Coated Tablets Containing Extended-Release Indapamide and Immediate-Release Amlodipine." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–09. https://doi.org/10.25258/ijddt.15.2.4.

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This study aimed to develop and optimize a manufacturing process for bilayer film-coated tablets containing extendedrelease indapamide and immediate-release amlodipine besylate. The formulation process included dry mixing, final blending, bilayer compression, film coating, and quality and stability evaluations. Optimization of the dry mixing and final blending times was performed to ensure uniformity and reproducibility. For the 10,000-tablet batch, the indapamide layer was processed using a high-speed mixer for 7 minutes at 500 rpm paddle speed and 1500 rpm chopper speed, followed by 5 minute

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Jamshiya.E*, and Anju.P. "FORMULATION, EVALUATION AND OPTIMIZATION OF FLOATING MATRIX TABLETS OF CARVEDILOL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 1146–58. https://doi.org/10.5281/zenodo.1188894.

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Bilayer floating tablets were prepared by direct compression using HPMC K100M and Ethyl cellulose as the release controlling polymers and sodium bicarbonate as a gas generating agent. The optimum concentrations of the above ingredients were determined under experimental conditions and on the basis of trial batches of the tablets. In the present study bilayer tablet was prepared manually using single station punching machine. Accurately weighed 150mg of sustained release layer powder mixture was fed manually into die cavity. Sustained release layer was compressed at mild compression force (2-3

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Ferdousi, Fatiha Momtaz, Farhani Safrin, Md Nawshed Ali, Abdullah Al Juhan, and Priyanka Akter. "Composition and Drug Release Characteristics of Bi-layered and Multi-layered Tablets: A Comprehensive Review." Journal of Drug Delivery and Therapeutics 15, no. 1 (2025): 169–76. https://doi.org/10.22270/jddt.v15i1.6936.

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Multilayer and Bilayer tablets are winning popularity over single-layer tablets because of their controlled release advantages. Since each layer of API must be compatible with the others and with excipients to extend the effects of the medication or drugs and improve patient compliance, technology for creating multilayers and bilayers is less widespread than that for single-layer tablets. Hydrophilic polymers are more frequently employed in the formulation of biliary and multilayer tablets as both medication carriers and release barriers. But the ratio of using polymer is different from each o

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Arti, Parmar* Akanksha jagwani Toshiba Khanam Narendra Gehalot Vikas Jain. "COMPREHENSIVE REVIEW ON FORMULATION AND MANUFACTURING TECHNIQUES OF BILAYER TABLETS." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3117–21. https://doi.org/10.5281/zenodo.13316959.

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Bilayer tablets are an inventive and adaptable drug delivery device because they have two layers, each with a unique drug release profile. This review summarises the development, manufacturing processes, formulation strategies, and pharmaceutical uses of bilayer tablets. Carefully choosing formulation ingredients is essential to the effectiveness of these tablets, taking into account medication compatibility as well as the effects of formulation variables on stability and bioavailability. A range of manufacturing approaches are examined, emphasising their scalability and appropriateness for ce

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S. Jabbar, Mohammed, and Yehia I. Khalil. "Formulation of Metoprolol Bilayer Tablets as an Oral Modified Release Dosage Form." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 19, no. 1 (2017): 21–30. http://dx.doi.org/10.31351/vol19iss1pp21-30.

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Metoprolol is a Î²1 adrenergic blocker used in treatment of heart diseases. Metoprolol (100mg) tablets was formulated as a modified release oral system utilizing the concept of bilayer system, first layer contained (30mg) as immediate release and the other (70mg) in the sustained release matrix. The immediate release layer consisted of lactose or microcrystalline cellulose as diluents with sodium starch glycolate or sodium croscarmellose as disintegrants. The result showed that the layer contains microcrystalline cellulose and 2% sodium starch glycolate gave disintegration time similar to that

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Sikdar, KM Yasif Kayes, Ahad Ahamed, Md Mahbubul Alam, Md Raihan Sarkar, and BK Sajeeb. "Formulation and In-vitro Evaluation of Bilayer Tablets of Atenolol and Amlodipine." Bangladesh Pharmaceutical Journal 22, no. 2 (2019): 153–69. http://dx.doi.org/10.3329/bpj.v22i2.42299.

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The present investigation was focused on formulation and in-vitro evaluation of a fixed dose bilayer tablet of two prominent antihypertensive agents, atenolol and amlodipine. The tablets were designed to immediately release atenolol (ATF1-ATF5) by using different percentage of sodium starch glycolate as super-disintegrant for prompt blood pressure lowering activity and sustain release amlodipine (AMF1- AMF5) by varying the percentage of hydroxy propyl methylcellulose (HPMC) for prolonged activity. After evaluation of the physical and chemical parameters of the formulations according to United

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Chun, Myung-Hee, Ji Yeon Kim, Eun-Seok Park, and Du Hyung Choi. "Development of a Robust Control Strategy for Fixed-Dose Combination Bilayer Tablets with Integrated Quality by Design, Statistical, and Process Analytical Technology Approach." Pharmaceutics 13, no. 9 (2021): 1443. http://dx.doi.org/10.3390/pharmaceutics13091443.

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Control strategy and quality by design (QbD) are widely used to develop pharmaceutical products and improve drug quality; however, studies on fixed-dose combination (FDC) bilayer tablets are limited. In this study, the bilayer tablet consisted of high-dose metformin HCl in a sustained-release layer and low-dose dapagliflozin l-proline in an immediate-release layer. The formulation and process of each layer were optimized using the QbD approach. A d-optimal mixture design and response surface design were applied to optimize critical material attributes and critical process parameters, respectiv

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Rekha, K. Wakhare* Anand D. Savkare Priyanka R. Nighute Priyanka S. Pagar. "FORMULATION AND DEVELOPMENT OF STABLE DOSAGE FORM OF AMLODIPINE BESYALTE AND BENAZEPRIL HYDROCHLORIDE TO OVERCOME PHYSICAL INCOMPATIBILITY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 504–22. https://doi.org/10.5281/zenodo.1036488.

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Amlodipine is a dihydropyridine calcium channel blocker with a slow onset and long duration of action. Benazepril hydrochloride is an angiotensin- converting enzyme inhibitor. But the Amlodipine besylate and Benazepril are physically incompatible drugs so there is need to keep them physically separated in dosage form. There are various approaches to overcome incompatibility. Among which the bilayer tablet is one of the novel, suitable approach and increasing attention from a variety of industries for various reasons viz. The purpose of this research is to study the physical incompatibility bet

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Umamaheswara Rao T, Smitha M, Maghiben M, and Damodara Velayudham A. "Analysis on the evaluation of aceclofenac bilayer tablets and its formulation using FT-IT method." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 323–28. http://dx.doi.org/10.26452/ijrps.v11ispl4.3798.

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The detached of the current research progress a bilayer tablet of aceclofenac utilizing sodium starch glycolate (SSG) and croscarmellose sodium (CCS) as super disintegrants for the formulation of immediate-release layer whereas polymers such as methocel K15M, Lubrizol 971P were utilized by the formulation of sustaining layer. The tablets were equipped by straight density technique. The organized tablets were estimated for pre-compressed parameters like micromeritic properties and post compressed parameters like bulk variation, aceclofenac satisfied and in-vitro dissolution studies. The in-vitr

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Das, Manoj Kr, Bhanu P. Sahu, and Jahan Nur Rahman Hazarika. "DEVELOPMENT OF BILAYER TABLETS FOR IMMEDIATE AND CONTROLLED RELEASE OF ALLICIN." International Journal of Current Pharmaceutical Research 9, no. 4 (2017): 153. http://dx.doi.org/10.22159/ijcpr.2017v9i4.20982.

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Objective: The purpose of this study was to develop and evaluate bilayer tablet for the immediate and controlled release of Allicin (Garlic Extract) for effective treatment of Hypertension.Methods: The immediate release layer was prepared by using super disintegrants-sodium starch glycolate and binder used xantham gum and the sustained release layer was prepared by using hydrophilic polymer like HPMC K 100 and PVP. Before preparation of the tablets, all the pre-formulation parameters were checked and the tablet of Allicin were prepared by direct compression method and was evaluated for physica

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Riaz, Muhammad, Liaqat Ali, Saba Javed, Syed Aatif Hussain, Hassan Haider Shah, and Khaleeq Anwer. "Development and in-vitro characterization of tiropramide tablets having immediate- and extended release layers." Journal of Contemporary Pharmacy 3, no. 1 (2019): 12–19. http://dx.doi.org/10.56770/jcp2019313.

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Purpose: The objective of this study was to explore the feasibility of developing of Tiropramide, bilayer tabletusing an immediate- and extended-release formulation. Method: After rheological performance of drug-excipientsmixture, Tiropramide HCl bilayer tablets were prepared by wet granulation method. FTIR analysis was performed toelucidate the compatibility behavior of drug and excipients. Effect of these varying concentrations of EthylCellulose (EC) and Hydroxy Propyl Methyl Cellulose (HPMC) were observed on the sustained release pattern of thematrices. Dissolution was performed by using 0.

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