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Relevant bibliographies by topics / Bile Acid Derivative

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Journal articles

Academic literature on the topic 'Bile Acid Derivative'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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Journal articles on the topic "Bile Acid Derivative"

1

Anwer, M. S., E. R. O'Maille, A. F. Hofmann, R. A. DiPietro, and E. Michelotti. "Influence of side-chain charge on hepatic transport of bile acids and bile acid analogues." American Journal of Physiology-Gastrointestinal and Liver Physiology 249, no. 4 (1985): G479—G488. http://dx.doi.org/10.1152/ajpgi.1985.249.4.g479.

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The importance of side-chain charge on hepatic uptake and biliary secretion of bile acids and analogues was studied using the isolated, perfused rat liver and the anesthetized rat with a bile fistula. Derivatives of cholic acid with negative, neutral, zwitterionic, or positive charges on the side chain were synthesized and studied. Hepatic uptake by the isolated perfused liver, determined by measuring the rate of disappearance of a single 20-mumol bolus added to the perfusate, was strongly influenced by side-chain charge. A fully positively charged bile acid derivative (cholylcholamine) and tw

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2

Landaeta Aponte, Roselis A., Andreas Luxenburger, Scott A. Cameron, et al. "Synthesis of Novel C/D Ring Modified Bile Acids." Molecules 27, no. 7 (2022): 2364. http://dx.doi.org/10.3390/molecules27072364.

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Bile acid receptors have been identified as important targets for the development of new therapeutics to treat various metabolic and inflammatory diseases. The synthesis of new bile acid analogues can help elucidate structure–activity relationships and define compounds that activate these receptors selectively. Towards this, access to large quantities of a chenodeoxycholic acid derivative bearing a C-12 methyl and a C-13 to C-14 double bond provided an interesting scaffold to investigate the chemical manipulation of the C/D ring junction in bile acids. The reactivity of this alkene substrate w

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3

Luxenburger, Andreas, Hannah Clemmens, Christopher Hastings та ін. "3α,7-Dihydroxy-14(13→12)abeo-5β,12α(H),13β(H)-cholan-24-oic Acids Display Neuroprotective Properties in Common Forms of Parkinson’s Disease". Biomolecules 13, № 1 (2022): 76. http://dx.doi.org/10.3390/biom13010076.

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Parkinson’s Disease is the most common neurodegenerative movement disorder globally, with prevalence increasing. There is an urgent need for new therapeutics which are disease-modifying rather than symptomatic. Mitochondrial dysfunction is a well-documented mechanism in both sporadic and familial Parkinson’s Disease. Furthermore, ursodeoxycholic acid (UDCA) has been identified as a bile acid which leads to increased mitochondrial function in multiple in vitro and in vivo models of Parkinson’s Disease. Here, we describe the synthesis of novel C-nor-D-homo bile acid derivatives and the 12-hydrox

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4

Muwal, Pradeep Kumar, Rajesh Kumar Chhatra, Shubhajit Das та Pramod S. Pandey. "Recognition of a Flavin Analogue by Novel Bile Acid-Based Receptors: Effects of Hydrogen Bonding and Aromatic π-Stacking Interactions". Australian Journal of Chemistry 70, № 12 (2017): 1263. http://dx.doi.org/10.1071/ch17220.

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Molecular recognition properties are reported for novel bile acid-based receptors that incorporate 2,6-diaminopyridine as a recognition unit. Apart from hydrogen-bonding interactions, the bile acid receptors exhibit significant aromatic π-stacking interactions with the aromatic fused ring of the flavin derivative. These studies provide rationalisation for the differences in binding behaviour of bile acid receptors having differing aromatic arm lengths towards a flavin analogue.

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5

Park, Kyeongsoon, Yoo-Shin Kim, Gee Young Lee, et al. "Antiangiogenic Effect of Bile Acid Acylated Heparin Derivative." Pharmaceutical Research 24, no. 1 (2006): 176–85. http://dx.doi.org/10.1007/s11095-006-9139-6.

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6

Fricker, G., G. Hugentobler, P. J. Meier, G. Kurz, and J. L. Boyer. "Identification of a single sinusoidal bile salt uptake system in skate liver." American Journal of Physiology-Gastrointestinal and Liver Physiology 253, no. 6 (1987): G816—G822. http://dx.doi.org/10.1152/ajpgi.1987.253.6.g816.

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To identify the sinusoidal bile acid uptake system(s) of skate liver, photoaffinity labeling and kinetic transport studies were performed in isolated plasma membranes as well as intact hepatocytes. In both preparations photoaffinity labeling with the photolabile bile salt derivative (7,7-azo-3 alpha, 12 alpha-dihydroxy-5 beta-[3 beta-3H]cholan-24-oyl)-2-aminoethanesulfonate revealed the presence of a predominant bile salt binding polypeptide with an apparent molecular weight of 54,000. The labeling of this polypeptide was inhibited by taurocholate and cholate in a concentration-dependent manne

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7

Pérez, Miriam, Marianela Sánchez, Mónica García, Laura P. Patiño C., Guillermo Blustein, and Jorge A. Palermo. "Antifouling activity of peracetylated cholic acid, a natural bile acid derivative." Steroids 149 (September 2019): 108414. http://dx.doi.org/10.1016/j.steroids.2019.05.006.

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8

THUMSER, Alfred E. A., and David C. WILTON. "The binding of cholesterol and bile salts to recombinant rat liver fatty acid-binding protein." Biochemical Journal 320, no. 3 (1996): 729–33. http://dx.doi.org/10.1042/bj3200729.

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The physiological role of liver fatty acid-binding protein (L-FABP) has yet to be clarified. An important feature of this member of the family of intracellular lipid-binding proteins is the wide range of compounds that have been identified as potential physiological ligands. By using recombinant L-FABP, the binding of cholesterol, bile salts and their derivatives has been investigated under conditions that allow a direct comparison of the binding affinities of these ligands for fatty acids. The results demonstrate an inability of L-FABP to bind cholesterol, although the anionic derivative, cho

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9

Sajisha, Valiparambil Sanjayan, and Uday Maitra. "Remarkable isomer-selective gelation of aromatic solvents by a polymorph of a urea-linked bile acid–amino acid conjugate." RSC Adv. 4, no. 81 (2014): 43167–71. http://dx.doi.org/10.1039/c4ra08957j.

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A urea-linked bile acid–amino acid conjugate was developed as a remarkable isomer-selective gelator for various disubstituted aromatic solvents. Polymorphism shown by the urea derivative was studied in detail which showed that only the amorphous polymorph acts as a gelator, but not the crystalline one.

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10

Spivak, W., and M. C. Carey. "Reverse-phase h.p.l.c. separation, quantification and preparation of bilirubin and its conjugates from native bile. Quantitative analysis of the intact tetrapyrroles based on h.p.l.c. of their ethyl anthranilate azo derivatives." Biochemical Journal 225, no. 3 (1985): 787–805. http://dx.doi.org/10.1042/bj2250787.

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We describe a facile and sensitive reverse-phase h.p.l.c. method for analytical separation of biliary bile pigments and direct quantification of unconjugated bilirubin (UCB) and its monoglucuronide (BMG) and diglucuronide (BDG) conjugates in bile. The method can be ‘scaled up’ for preparative isolation of pure BDG and BMG from pigment-enriched biles. We employed an Altex ultrasphere ODS column in the preparative steps and a Waters mu-Bondapak C18 column in the separatory and analytical procedures. Bile pigments were eluted with ammonium acetate buffer, pH 4.5, and a 20 min linear gradient of 6

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