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Journal articles on the topic 'Biliaire, sel'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Lindheimer, M., J. C. Montet, J. Molenat, A. M. Montet, and B. Brun. "Solubilité micellaire et diffusion de l’acide oléique dans des mélanges sel biliaire-phospholipide." Journal de Chimie Physique 84 (1987): 947–50. http://dx.doi.org/10.1051/jcp/1987840947.

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2

Guerra Herbas, Daniel, Daniel Jaldin Alvarez, and Anahi Canedo Bermudez. "Manejo endoscópico de la estenosis biliar postoperatoria a propósito de un caso." Gaceta Medica Boliviana 41, no. 1 (October 22, 2020): 58–60. http://dx.doi.org/10.47993/gmb.v41i1.154.

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Las estenosis biliares postoperatorias principalmente las post colecistectomía representan la causa más frecuente de estenosis biliares benignas. Presentamos el caso de una paciente del sexo femenino que acude por presentar ictericia, coluria, alzas térmicas y dolor abdominal con el único antecedente de una colecistectomía laparoscópica. Los exámenes de laboratorio presentan un patrón obstructivo colestásico se procede a realizar colangiopancreatografía retrógrada endoscópica (ERCP), observando estenosis de la vía biliar en relación a los clips metálicos. Se realizó dilataciones mecánicas e hidrostáticas de vía biliar además de la colocación, secuencial de dos prótesis biliares de plástico. A los 6 meses se retira las prótesis biliares no evidenciando estenosis en la colangiografía de control. El manejo de las estenosis benignas representa un reto ya sea para el endoscopista, como para el cirujano, la colangiopancreatografía retrógrada endoscópica juega un papel muy importante diagnóstico y terapéutico principalmente con la colocación de prótesis biliares.

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3

Huang, Ping, Hao Zhang, Xiao-Feng Zhang, Wen Lv, and Zhen Fan. "Application and Value of Endoscopic Ultrasonography Guided Biliary Interventional Therapy in Patients With Biliary Obstruction and Surgically Altered Anatomy." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 30, no. 5 (June 1, 2020): 454–58. http://dx.doi.org/10.1097/sle.0000000000000813.

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4

Katsinelos, Panagiotis, Jannis Kountouras, George Paroutoglou, Grigoris Chatzimavroudis, Dimitris Paikos, Christos Zavos, Konstantinos Karakousis, George Gelas, and Dimitris Tzilves. "Migration of Plastic Biliary Stents and Endoscopic Retrieval." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 19, no. 3 (June 2009): 217–21. http://dx.doi.org/10.1097/sle.0b013e3181a031f5.

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5

Aswad, Mayar G., Ashley R. Dennison, Christopher P. Neal, Matthew S. Metcalfe, and Giuseppe Garcea. "Biliary Stenting for Benign and Malignant Obstructive Jaundice." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 24, no. 4 (August 2014): 385–90. http://dx.doi.org/10.1097/sle.0b013e3182a50e59.

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6

Zang, Jinfeng, Chi Zhang, and Junye Gao. "Guidewire-assisted Transpancreatic Sphincterotomy for Difficult Biliary Cannulation." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 24, no. 5 (October 2014): 429–33. http://dx.doi.org/10.1097/sle.0000000000000062.

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7

Audouy, Cyril, Jérémie Thereaux, Gaby Kansou, Geoffroy Leroux, Bogdan Badic, and Jean P. Bail. "Primary Closure Versus Biliary Drainage After Laparoscopic Choledocotomy." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 26, no. 1 (February 2016): e32-e36. http://dx.doi.org/10.1097/sle.0000000000000242.

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8

Lyons, Hernando, Karen H. Hagglund, and Yamen Smadi. "Outcomes After Laparoscopic Cholecystectomy in Children With Biliary Dyskinesia." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 21, no. 3 (June 2011): 175–78. http://dx.doi.org/10.1097/sle.0b013e31821db7b2.

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9

Kim, Bum-Soo, Sun-Hyung Joo, Sung-Jig Lim, and Kwang-Ro Joo. "Intrahepatic Biliary Intraductal Papillary Mucinous Neoplasm With Gallbladder Agenesis." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 23, no. 2 (April 2013): e61-e64. http://dx.doi.org/10.1097/sle.0b013e31824a7e6c.

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10

Polydorou, Andreas, Konstantinos Karapanos, Antonios Vezakis, Aikaterini Melemeni, Vasilios Koutoulidis, Georgios Polymeneas, and Georgios Fragulidis. "A Multimodal Approach to Acute Biliary Pancreatitis During Pregnancy." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 22, no. 5 (October 2012): 429–32. http://dx.doi.org/10.1097/sle.0b013e31825e38bb.

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11

Shapey, Iestyn M., Shameen S. Jaunoo, Kasun M. Arachchilage, and Lam C. Tan. "Biliary Tract Imaging for Retained Calculi After Laparoscopic Cholecystectomy." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 22, no. 5 (October 2012): 459–62. http://dx.doi.org/10.1097/sle.0b013e3182623186.

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12

Parlak, Erkan, Selçuk Dişibeyaz, Bülent Ödemiş, Öykü Tayfur, Aydin Ş. Köksal, Semih Sezer, Nurgül Şaşmaz, and Burhan Şahin. "Endoscopic Treatment of Biliary Fistulas Developing After Liver Resections." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 23, no. 5 (October 2013): 453–58. http://dx.doi.org/10.1097/sle.0b013e31828e3c6f.

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13

Yuan, Haicheng, Mingfang Qin, Rong Liu, and Sanyuan Hu. "Timing of Cholecystectomy for Biliary Pancreatitis in Chinese Patients." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 25, no. 4 (August 2015): 368–71. http://dx.doi.org/10.1097/sle.0000000000000099.

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14

Huang, Ping, Hao Zhang, Xiao-Feng Zhang, Wen Lv, and Songmei Lou. "Comparison of Endoscopic Ultrasonography Guided Biliary Drainage and Percutaneous Transhepatic Biliary Drainage in the Management of Malignant Obstructive Jaundice After Failed ERCP." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 27, no. 6 (December 2017): e127-e131. http://dx.doi.org/10.1097/sle.0000000000000485.

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15

Lo, Cheng Hean, Stephen Chung, and Robert D. Bohmer. "A Devastating Complication: Duodenal Perforation Due to Biliary Stent Migration." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 18, no. 6 (December 2008): 608–10. http://dx.doi.org/10.1097/sle.0b013e318185a07a.

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16

Wang, Zhifei, Quanda Liu, Junzhou Chen, Weihong Duan, and Ningxin Zhou. "Da Vinci Robot-assisted Anatomic Left Hemihepatectomy and Biliary Reconstruction." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 23, no. 3 (June 2013): e89. http://dx.doi.org/10.1097/sle.0b013e3182747607.

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17

Katsinelos, Panagiotis, George Paroutoglou, Grigoris Chatzimavroudis, Athanasios Beltsis, Kostas Mimidis, Taxiarchis Katsinelos, Ioannis Pilpilidis, and Basilis Papaziogas. "Successful Treatment of Intractable Bronchobiliary Fistula Using Long-term Biliary Stenting." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 17, no. 3 (June 2007): 206–9. http://dx.doi.org/10.1097/sle.0b013e318058822d.

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18

Hamada, Tsuyoshi, Hiroyuki Isayama, Yousuke Nakai, Osamu Togawa, Hirofumi Kogure, Naminatsu Takahara, Dai Mohri, et al. "Antireflux Metal Stent With an Antimigration System for Distal Malignant Biliary Obstruction." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 25, no. 3 (June 2015): 212–17. http://dx.doi.org/10.1097/sle.0000000000000149.

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19

Seager, Alexander, Thomas C. Hall, Ashley R. Dennison, and Giuseppe Garcea. "Economic Implications of Providing Emergency Cholecystectomy for All Patients With Biliary Pathology." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 25, no. 4 (August 2015): 337–42. http://dx.doi.org/10.1097/sle.0000000000000169.

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20

Pek, Chulja J., Monique van Dijk, Bas Groot Koerkamp, Adriaan Moelker, and Casper H. J. van Eijck. "A National Survey on Peri-interventional Management of Percutaneous Transhepatic Biliary Drainage." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 27, no. 4 (August 2017): 253–56. http://dx.doi.org/10.1097/sle.0000000000000445.

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21

Teng, Fei, Yu-Tao Xian, Jia Lin, Yu Li, and An-Le Wu. "Comparison of Unilateral With Bilateral Metal Stenting for Malignant Hilar Biliary Obstruction." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 29, no. 1 (February 2019): 43–48. http://dx.doi.org/10.1097/sle.0000000000000594.

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22

Adas, Gokhan, Soykan Arikan, Emin Gurbuz, Servet Karahan, Bahar Eryasar, Oguzhan Karatepe, and Yaman Tekant. "Comparison of Endoscopic Therapeutic Modalities for Postoperative Biliary Fistula of Liver Hydatid Cyst." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 20, no. 4 (August 2010): 223–27. http://dx.doi.org/10.1097/sle.0b013e3181e12ee6.

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23

Vihervaara, Hanna, and Juha M. Grönroos. "Feasibility of the Novel 3-Step Protocol for Biliary Cannulation—A Prospective Analysis." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 22, no. 2 (April 2012): 161–64. http://dx.doi.org/10.1097/sle.0b013e318247bb84.

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24

Vilallonga, Ramon, Ronnie Pimentel, and Raul J. Rosenthal. "Hybrid Endolaparoscopic Management of Biliary Tract Pathology in Bariatric Patients After Gastric Bypass." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 23, no. 5 (October 2013): e188-e190. http://dx.doi.org/10.1097/sle.0b013e31828b85e8.

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25

Ito, Yukiko, Yousuke Nakai, Hiroyuki Isayama, Takeshi Tsujino, Tsuyoshi Hamada, Gyotane Umefune, Dai Akiyama, et al. "Impact of Preoperative Biliary Drainage on Surgical Outcomes in Periampullary and Hilar Malignancy." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 26, no. 2 (April 2016): 150–55. http://dx.doi.org/10.1097/sle.0000000000000252.

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26

Nakahara, Kazunari, Ryo Morita, Yosuke Michikawa, Keigo Suetani, Nozomi Morita, Akashi Fujita, Junya Sato, et al. "Endoscopic Transpapillary Gallbladder Drainage for Acute Cholecystitis After Biliary Self-Expandable Metal Stent Placement." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 30, no. 5 (May 8, 2020): 416–23. http://dx.doi.org/10.1097/sle.0000000000000802.

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27

Beninato, Toni, David A. Kleiman, Ashwin Soni, David A. Nissan, Filippo Filicori, Elliot L. Servais, Thomas J. Fahey, and Rasa Zarnegar. "Expanding the Indications for Single-incision Laparoscopic Cholecystectomy to All Patients With Biliary Disease." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 25, no. 1 (February 2015): 10–14. http://dx.doi.org/10.1097/sle.0000000000000095.

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28

Houghton, Eduardo J., Manuel Zeledón, Pablo Acquafresca, Caetano Finger, Mariano Palermo, and Mariano E. Giménez. "Prospective Comparison of Bleeding Complications Between Right and Left Approaches in Percutaneous Biliary Drainage." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 29, no. 1 (February 2019): 7–12. http://dx.doi.org/10.1097/sle.0000000000000609.

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29

Diaz, Jean Pierre, and Robert Connes. "Ontogenesis of the biliary tract in a teleost, the sea bass Dicentratchus labrax L." Canadian Journal of Zoology 75, no. 5 (May 1, 1997): 740–45. http://dx.doi.org/10.1139/z97-095.

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Ontogenesis of the biliary tract in the sea bass Dicentrarchus labrax was studied using transmission electron microscopy from hatching to 3 months of age. The biliary intrahepatic network and extrahepatic ducts develop during primordial liver differentiation. When hepatoblasts form groups and polarise, they create bile canaliculi at their apical pole. The main characteristic of these bile canaliculi is that they are roughly spherical. The biliary epithelial cells first appear just before mouth opening in prelarvae (day 5 after hatching). They constitute not only composite canaliculi with hepatocytes, but also cholangioles. Biliary ductules and ducts are visible from day 10 onward. During ontogenesis, the primordial liver separates from the wall of the gut but remains connected to it by a cell cord. This cell cord becomes tubular, with an axial cavity dilating at the other end and giving successively the choledoc duct, cystic duct, and gall bladder.

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30

Park, Seon-Young, Chang-Hwan Park, Sung-Bum Cho, Wan-Sik Lee, Jung-Chul Kim, Chul-Kyun Cho, Young-Eun Joo, Hyun-Soo Kim, Sung-Kyu Choi, and Jong-Sun Rew. "What is Appropriate Procedure for Preoperative Biliary Drainage in Patients With Obstructive Jaundice Awaiting Pancreaticoduodenectomy?" Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 21, no. 5 (October 2011): 344–48. http://dx.doi.org/10.1097/sle.0b013e3182318d2f.

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31

Romano-Munive, Adriana F., Francisco Valdovinos-Andraca, Javier Elizondo-Rivera, Miguel A. Ramírez-Luna, Salvador Herrera-Gómez, and Félix I. Téllez-Ávila. "High Rate of Post-ERCP Pancreatitis in Patients Undergoing Endoscopic Treatment of Benign Biliary Stricture." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 24, no. 2 (April 2014): 164–67. http://dx.doi.org/10.1097/sle.0b013e31828f6b3b.

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32

Gao, Dao-jian, Hong-Zhan Zhang, Bing Hu, Rui Lu, and Shu-Ping Wang. "Establishment of a Swine Benign Biliary Stricture Model of Endobiliary Thermal Injury With a Diathermic Sheath." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 30, no. 6 (October 16, 2020): e52-e58. http://dx.doi.org/10.1097/sle.0000000000000872.

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33

Manouras, Andreas, Fotios Archodovassilis, Emmanuel E. Lagoudianakis, Dimitrios Tsekouras, Michael Genetzakis, Nikolaos Pararas, Andreas Romanos, and Vaggelogiannis Katergiannakis. "Vertical Rotation and Impaction to the Choledochal Duct of a Migrated Biliary Self-expanding Metal Stent." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 17, no. 5 (October 2007): 416–17. http://dx.doi.org/10.1097/sle.0b013e3180959b27.

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34

Wai, Chun-Tao, Sing-Shang Ngoi, Peter Y. T. Goh, Kang-Hoe Lee, Michael Lin, and Kai-Chah Tan. "Modified Rendezvous Technique in Management of Biliary Leak in Right Lobe Live Donor Liver Transplant Recipients." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 19, no. 4 (August 2009): e143-e145. http://dx.doi.org/10.1097/sle.0b013e3181aa596f.

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35

Zou, Xiao-Ping, Ming Zhang, Wen LI, and Yu-lin WU. "Biliary Intraductal Papillary-mucinous Neoplasm Diagnosed by Peroral Direct Cholangioscopy Using a Slim Upper Endoscope (With Video)." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 21, no. 5 (October 2011): e263-e265. http://dx.doi.org/10.1097/sle.0b013e318225d145.

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36

Akimboye, F., T. Lloyd, S. Hobson, and G. Garcea. "Migration of Endoscopic Biliary Stent and Small Bowel Perforation Within an Incisional Hernia." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 16, no. 1 (February 2006): 39–40. http://dx.doi.org/10.1097/01.sle.0000202198.74569.5a.

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37

Yokoyama, Kazutake, Nobuhiko Tanigawa, Akihito Ogata, Toshihiro Nagai, and Masayuki Higashino. "Laparoscopic Technique and Initial Experiences of Choledocholithotomy Closure With Knotless Unidirectional Barbed Sutures After Surgery for Biliary Stone Disease." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 25, no. 4 (August 2015): e129-e133. http://dx.doi.org/10.1097/sle.0000000000000122.

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38

Zhang, Feng-Qin, Lin Li, Ping-Chao Huang, Feng-Fei Xia, Lei Zhu, and Chi Cao. "Stent Insertion With High Intensity–Focused Ultrasound Ablation for Biliary Obstruction Caused by Pancreatic Carcinoma: A Randomized Controlled Trial." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 31, no. 3 (February 17, 2021): 298–303. http://dx.doi.org/10.1097/sle.0000000000000918.

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39

Mangla, Vivek, Jagdish Chander, Anubhav Vindal, Pawanindra Lal, and Vinod K. Ramteke. "A Randomized Trial Comparing the Use of Endobiliary Stent and T-Tube for Biliary Decompression After Laparoscopic Common Bile Duct Exploration." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 22, no. 4 (August 2012): 345–48. http://dx.doi.org/10.1097/sle.0b013e31825b297d.

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40

Luigiano, Carmelo, Marco Bassi, Francesco Ferrara, Carlo Fabbri, Stefania Ghersi, Carmela Morace, Pierluigi Consolo, et al. "Placement of a New Fully Covered Self-expanding Metal Stent for Postoperative Biliary Strictures and Leaks Not Responding to Plastic Stenting." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 23, no. 2 (April 2013): 159–62. http://dx.doi.org/10.1097/sle.0b013e318278c201.

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41

Chung-Davidson, Yu-Wen, Chu-Yin Yeh, and Weiming Li. "The Sea Lamprey as an Etiological Model for Biliary Atresia." BioMed Research International 2015 (2015): 1–17. http://dx.doi.org/10.1155/2015/832943.

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Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in infants that results in obstruction of both extrahepatic and intrahepatic bile ducts. It is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes developmental BA with transient cholestasis and fibrosis during metamorphosis, but emerges as a fecund adult with steatohepatitis and fibrosis in the liver. In this paper, we present new histological evidence and compare the sea lamprey to existing animal models to highlight the advantages and possible limitations of using the sea lamprey to study the etiology and compensatory mechanisms of BA and other liver diseases. Understanding the signaling factors and genetic networks underlying lamprey BA can provide insights into BA etiology and possible targets to prevent biliary degeneration and to clear fibrosis. In addition, information from lamprey BA can be used to develop adjunct treatments for patients awaiting or receiving surgical treatments. Furthermore, the cholestatic adult lamprey has unique adaptive mechanisms that can be used to explore potential treatments for cholestasis and nonalcoholic steatohepatitis (NASH).

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42

Katsinelos, Panagiotis, Jannis Kountouras, George Germanidis, George Paroutoglou, Dimitris Paikos, Georgia Lazaraki, Ioannis Pilpilidis, Grigoris Chatzimavroudis, Kostas Fasoulas, and Christos Zavos. "Sequential or Simultaneous Placement of Self-expandable Metallic Stents for Palliation of Malignant Biliary and Duodenal Obstruction Due to Unresectable Pancreatic Head Carcinoma." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 20, no. 6 (December 2010): 410–15. http://dx.doi.org/10.1097/sle.0b013e3182001f26.

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43

Masyuk, Anatoly I., Tatyana V. Masyuk, Pamela S. Tietz, Patrick L. Splinter, and Nicholas F. LaRusso. "Intrahepatic bile ducts transport water in response to absorbed glucose." American Journal of Physiology-Cell Physiology 283, no. 3 (September 1, 2002): C785—C791. http://dx.doi.org/10.1152/ajpcell.00118.2002.

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The physiological relevance of the absorption of glucose from bile by cholangiocytes remains unclear. The aim of this study was to test the hypothesis that absorbed glucose drives aquaporin (AQP)-mediated water transport by biliary epithelia and is thus involved in ductal bile formation. Glucose absorption and water transport by biliary epithelia were studied in vitro by microperfusing intrahepatic bile duct units (IBDUs) isolated from rat liver. In a separate set of in vivo experiments, bile flow and absorption of biliary glucose were measured after intraportal infusion of d-glucose or phlorizin. IBDUs absorbedd-glucose in a dose- and phlorizin-dependent manner with an absorption maximum of 92.8 ± 6.2 pmol · min−1 · mm−1. Absorption of d-glucose by microperfused IBDUs resulted in an increase of water absorption ( J v = 3−10 nl · min−1 · mm−1, P f = 40 × 10−3 cm/sec). Glucose-driven water absorption by IBDUs was inhibited by HgCl2, suggesting that water passively follows absorbed d-glucose mainly transcellularly via mercury-sensitive AQPs. In vivo studies showed that as the amount of absorbed biliary glucose increased after intraportal infusion ofd-glucose, bile flow decreased. In contrast, as the absorption of biliary glucose decreased after phlorizin, bile flow increased. Results support the hypothesis that the physiological significance of the absorption of biliary glucose by cholangiocytes is likely related to regulation of ductal bile formation.

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44

Pradhan, Sumita, and JN Shah. "Presence of choledocholithiasis in patients undergoing cholecystectomy for mild biliary pancreatitis." Bangladesh Journal of Medical Science 15, no. 4 (December 18, 2016): 517–21. http://dx.doi.org/10.3329/bjms.v15i4.30711.

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Background: Standard recommendations for patients recovering from an episode of biliary pancreatitis include cholecystectomy with intra operative cholangiogram or ERCP during the same hospital admission as it is believed that the instigating factor is the passage of stones through the common bile duct. As ERCP is not widely available and expensive, cholecystectomy with IOC is routinely performed to rule out choledocholithiasis. However detection of common bile duct stones is challenging. Whether these patients undergoing cholecystectomy require direct common bile duct evaluation is controversial.Objectives: To see the presence of common bile duct stones in patients with resolving acute mild biliary pancreatitis.Materials and Methods: Patients admitted in the surgical ward in Patan and Bir hospital with the diagnosis of mild acute biliary pancreatitis that underwent cholecystectomy with intra operative cholangiography from August 2010 to July 2011 were studied. The outcome of cholangiogram was analyzed together with findings of Common bile duct exploration.Result and Conclusion: A total of 52 patients with acute mild biliary pancreatitis were operated during this period. The Common bile duct stone was found in 1.9%. Out of four patients with abnormal cholangiogram, only one patient (25%) had stone on exploration, rest of the three cases (75%) had negative exploration. The presence of common bile duct stone in case of mild acute biliary pancreatitis undergoing cholecystectomy is very low (1.96%), and thus policy of selective IOC should be applied for cases with mild biliary pancreatitis.Bangladesh Journal of Medical Science Vol.15(4) 2016 p.517-521

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45

Javle, Milind M., John D. Hainsworth, Charles Swanton, Howard A. Burris, Razelle Kurzrock, Christopher Sweeney, Funda Meric-Bernstam, et al. "Pertuzumab + trastuzumab for HER2-positive metastatic biliary cancer: Preliminary data from MyPathway." Journal of Clinical Oncology 35, no. 4_suppl (February 1, 2017): 402. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.402.

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402 Background: Biliary cancers have a high mortality rate, with limited treatment options. While HER2 is overexpressed in 9-20% of biliary cancers, it has not been fully explored as a therapeutic target. MyPathway is a multi-basket study evaluating the efficacy and safety of targeted therapies in non-indicated tumor types harboring relevant genetic alterations. We present preliminary data for patients with HER2-positive metastatic biliary cancer receiving HER2-targeted treatment with pertuzumab + trastuzumab. Methods: MyPathway (NCT02091141) is an open-label, multicenter, phase IIA study. Patients in this subset analysis had refractory metastatic biliary cancer with HER2 amplification/overexpression or putative activating mutations by gene sequencing, FISH, or IHC. Patients received standard doses of pertuzumab + trastuzumab until disease progression or unacceptable toxicity. The primary endpoint is investigator-assessed overall response rate (RECIST v1.1). Results: As of July 31, 2016, 11 patients with HER2-positive biliary cancer (HER2-amplified/overexpressed, n = 8; HER2-mutated, n = 3 [D277Y, S310F, and A775-G776insYVMA]) have been enrolled. At a median follow-up of 4.2 (range 2.0–12.0) months, 4 patients had partial responses (PR) and 3 had stable disease (SD) for > 4 months (Table). Safety was consistent with the package inserts. Conclusions: Preliminary results indicate that pertuzumab + trastuzumab has activity in HER2 amplified/overexpressed/mutated metastatic biliary tumors, suggesting HER2 as a therapeutic target for these rare cancers. Accrual to MyPathway is ongoing. Clinical trial information: NCT02091141. [Table: see text]

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Ueno, Makoto, Takeharu Yamanaka, Takashi Ogura, Atushi Yamaguchi, Nobumasa Mizuno, Masato Ozaka, Hideki Ueno, et al. "The influence of biliary drainage in patients with advanced pancreatic cancer receiving FOLFIRINOX." Journal of Clinical Oncology 36, no. 4_suppl (February 1, 2018): 378. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.378.

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378 Background: FOLFIRINOX (FFX) is a standard of care for patients (pts) with advanced pancreatic cancer (APC). In the original FFX report by Conroy (NEJM, 2011), pts with a biliary drainage were limited and the occurrence of cholangitis was not reported. In practice, however, we experience that a certain fraction of APC pts needs a biliary drainage and some of them have an elevated risk of cholangitis or febrile neutropenia (FN) during the course of FFX. We evaluated the influence of biliary drainage on the efficacy and safety of FFX. Methods: We used individual data from nationwide survey of FFX (JASPAC06). The JASPAC06 was a prospective registry of pts with FFX treated in clinical practice and enrolled 399 pts between December 2013 and November 2014 from 27 centers in Japan. We evaluated the associations of OS and PFS, as well as the frequencies of cholangitis and FN, with the use of biliary drainage. We excluded resected cases because an operative method with choledochojejunostomy was unknown. Results: Of 399 pts in the JASPAC06, 319 were eligible for this analysis and 80 resected cases were excluded. The use of biliary drainage was seen in 28% of pts (mainly bile duct stent inserted); primary dose reduction (modified FFX), 67%; previously untreated tumor, 77%; distant metastases, 76%; pancreas head, 47%. The main results are shown in the table. In summary, cholangitis was more frequent in pts with biliary drainage. Grade 3 or higher FN as well as CRP elevation was observed more frequently in pts with biliary drainage. There was no difference in PFS (median PFS, 7.3 vs. 6.5 mo; logrank, p=0.24) and OS (median OS, 12.3 vs. 12.2 mo; p=0.86) between the two groups. Conclusions: Our observation that the frequency of FN and CRP elevation was significantly higher in pts with biliary drainage indicates a higher risk of infection during the FFX treatment by using biliary drainage.[Table: see text]

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Sakai, Yuji, Toshio Tsuyuguchi, Takeshi Ishihara, Harutoshi Sugiyama, Kaoru Miyakawa, Shin Yasui, Reiko Eto, et al. "The Successful Use of Peroral Cholangioscopy for the Diagnosis and Treatment of the Biliary Tract Lesions and Giant Bile Duct Stones in a 76-Year-Old Man." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 19, no. 6 (December 2009): e237-e240. http://dx.doi.org/10.1097/sle.0b013e3181bbd67a.

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Smith, D. D., R. A. Nelson, and R. Schwarz. "A comparison of competing lymph node staging schemes in resectable biliary cancer." Journal of Clinical Oncology 29, no. 4_suppl (February 1, 2011): 166. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.166.

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166 Background: New schemes for lymph node (LN) staging have been proposed to improve upon the AJCC TNM cancer staging convention. We compared AJCC N0/N1 staging with the LN ratio and logarithmic odds systems in predicting overall survival (OS) in resectable biliary cancer patients, including cancer of the gallbladder, extrahepatic bile duct (EHBD), and ampulla of Vater (AOV). Methods: In a large, multiinstitutional U.S.-based biliary cancer data set, we identified 4,288 nonmetastatic resectable biliary cancer patients diagnosed between 1988 and 2006. We compared each subject's AJCC N stage with the two novel staging schemes. We split patients into two groups above or below the median for the two novel staging schemes and analyzed OS. Our comparison metric was the log-rank chi-squared statistic. As a baseline comparator, we included the median number of LNs resected. Results: Median (range) of follow- up was 2.5 years (1 month–19 years), with an overall median survival of 2.0 years (95% CI: 2.0–2.1 years). For all biliary patients combined, we found that the AJCC N0/N1 system and LN ratio schemes performed similarly. For gallbladder cancers (N= 1,340), LN ratio showed higher OS prediction utility, whereas in EHBD (N= 1,083) and AOV cancers (N= 1,865), AJCC staging was superior among competing methods. Conclusions: The LN ratio method is comparable with AJCC N staging for OS prediction, although the AJCC scheme is superior in two of three biliary cancers. We conclude that AJCC staging remains adequate for staging biliary cancers given the newer staging proposals. [Table: see text] No significant financial relationships to disclose.

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Pradhan, S., S. Shah, S. Maharjan, and JN Shah. "Presence of choledocholithiasis in patients undergoing cholecystectomy for mild biliary pancreatitis." Journal of Society of Surgeons of Nepal 17, no. 1 (July 4, 2016): 11–15. http://dx.doi.org/10.3126/jssn.v17i1.15175.

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Introduction: Standard recommendations for patients recovering from an episode of biliary pancreatitis include cholecystectomy with intra operative cholangiogram or ERCP during the same hospital admission as it is believed that the instigating factor is the passage of stones through the common bile duct. As ERCP is not widely available and expensive, cholecystectomy with IOC is routinely performed to rule out choledocholithiasis. However detection of common bile duct stones is challenging. Whether these patients undergoing cholecystectomy require direct common bile duct evaluation is controversial. Objective of the study was to see the presence of common bile duct stones in patients with resolving acute mild biliary pancreatitis. Methods: Patients admitted in the surgical ward in Patan Hospital and Bir Hospital with the diagnosis of mild acute biliary pancreatitis who underwent cholecystectomy with intra-operative cholangiography from August 2010 to July 2012 were studied. The outcome of cholangiogram was analyzed together with findings of common bile duct exploration. Results: A total of 52 patients with acute mild biliary pancreatitis were operated during this period. The common bile duct stone was found in 1.9%. Out of four patients with abnormal cholangiogram, only one patient (25%) had stone on exploration, rest of the three cases (75%) had negative exploration.Conclusion: The presence of common bile duct stone in case of mild acute biliary pancreatitis undergoing cholecystectomy is very low (1.96%), and thus policy of selective IOC should be applied for cases with mild biliary pancreatitis.Journal of Society of Surgeons of Nepal Vol.17(1) 2014: 11-15

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Maharjan, Dhiresh Kumar, and Prabin Bikram Thapa. "Use of indocyanine green fluorescence during hepatobiliary surgery." Journal of Kathmandu Medical College 9, no. 2 (June 30, 2020): 74–80. http://dx.doi.org/10.3126/jkmc.v9i2.35525.

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Background: Indocyanine green fluorescence image has been used in hepatobiliary surgery, which was mainly started by Japanese surgeons to visualize hepatobiliary structures probably because it is regarded as a reagent for estimation of hepatic function. Objectives: The objective of this study is to see the feasibility of use of indocyanine green in our setting during hepatobiliary surgery and its potential applications in the surgical treatment of benign and malignant liver pathology along with its selective use during difficult cholecystectomy to visualize extrahepatic biliary radical. Methodology: This is a prospective cross sectional observational study performed including all consecutive patients who were posted for liver resection, both benign or malignant and selectively used in biliary surgery when biliary anatomy was uncertain. Results: A total of thirty-nine patients had usage of indocyanine green, with a mean age of 51.6 ± 11.6 years (range, 31-75 years). In all our patients we were able to visualize the biliary system and liver parenchymal lesion.In the selective use of indocyanine green during difficult biliary anatomy during laparoscopic cholecystectomy 15/400 (3.75%), we were able to delineate biliary tree and hence five patients (1.2%) had to be converted to open cholecystectomy further preventing injury to the bile duct. Conclusion: Indocyanine green fluorescence imaging can be used safely and easily to identify liver tumors, hepatic segments, and extrahepatic bile ducts in real time during open and minimally invasive surgery. This allows surgeons to map the anatomical variations, status of resection margin and prevent surgical complications.

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