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Journal articles on the topic 'Biliary hamartomas'

Author: Grafiati

Published: 5 June 2025

Last updated: 24 June 2025

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1

Parvin, A., and ZI Chowdhury. "Multiple Biliary Hamartomas (von Meyenburg complexes) - A Case Report." Pulse 9, no. 1 (2017): 60–63. http://dx.doi.org/10.3329/pulse.v9i1.31884.

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Multiple biliary hamartoma (MBH) is a rare cause of multiple benign hepatic lesions. The condition is also known as von Meyenburg complexes, multiple bile duct hamartomas and biliary microhamartomas. MBH is asymptomatic and usually found incidentally where it is important to differentiate from other causes of multiple liver lesions particularly liver metastases. Histologically, they consist of cystic dilatation of the bile duct, encompassed by fibrous stroma. We reported a 74 year old male patient with multiple hepatic lesions which ultrasonographic appearance suggested multiple hepatic cysts. The diagnosis of MBH was made by MRCP of whole abdomen. Recognition of this unusual lesion is essential to avoid confusion with other cystic tumors of the liver specially liver metastases and to learn more about its natural history and response to treatment.Pulse Vol.9 January-December 2016 p.60-63

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2

Duran, Semra, Sidika Ciray Yigit, and Mehtap Cavusoglu. "Multiple Biliary Hamartomas: Imaging Findings." Medical Journal of Okmeydani Training and Research Hospital 30, no. 2 (2014): 112–16. http://dx.doi.org/10.5222/otd.2014.112.

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3

Zheng, Rong-Qin. "Imaging findings of biliary hamartomas." World Journal of Gastroenterology 11, no. 40 (2005): 6354. http://dx.doi.org/10.3748/wjg.v11.i40.6354.

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4

Cheung, Y. C., C. F. Tan, Y. L. Wan, K. W. Lui, and C. C. Tsai. "MRI of multiple biliary hamartomas." British Journal of Radiology 70, no. 833 (1997): 527–29. http://dx.doi.org/10.1259/bjr.70.833.9227236.

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5

Shirazi, Nadia, Neena V. Chauhan, Smita Chandra, and Sunil Saini Kumar. "Von Meyenburg complex clinically presenting as metastatic liver nodule: A rare finding in an elderly male." Journal of Laboratory Physicians 11, no. 04 (2019): 385–87. http://dx.doi.org/10.4103/jlp.jlp_55_19.

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AbstractVon Meyenburg complex is a benign biliary hamartoma observed in approximately 3% of the autopsies conducted. These hamartomas are small, multiple and can be seen anywhere in the liver. There is usually no abnormality in liver function tests, and the patient is mostly asymptomatic. They serve as a diagnostic dilemma, particularly during metastatic workup in suspected cancer patients. Imaging studies are usually noncontributory, and biopsy is necessary for a definite diagnosis. We present here a middle-aged North Indian male who underwent liver biopsy to rule out metastasis.

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6

Gupta, Amit, Depak Rajput, Utkarsh Kumar, Sweety Gupta, Ashok Singh, and Sumit Sanyal. "Brunner’s gland hamartoma presenting as gastric outlet obstruction: unusual presentation and review of literature." Tropical Doctor 50, no. 1 (2019): 68–70. http://dx.doi.org/10.1177/0049475519870980.

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Brunner’s gland hamartoma (or Brunneroma) is an uncommon tumour with an incidence of <0.01%, accounting for approximately 5–10% of benign duodenal tumours. Usually asymptomatic, it may manifest occasionally with duodenal obstruction or upper gastrointestinal haemorrhage and rarely with biliary fistulation, cholestatic jaundice and intussusception. It may be associated with uraemia and chronic pancreatitis. The diagnosis is usually confirmed by imaging studies and upper gastrointestinal endoscopy. Surgical excision or endoscopic resection is preferred for symptomatic large hamartomas. Here we report a case of 45-year-old man presenting with features of pancreatitis and gastric outlet obstruction due to a large Brunner’s gland hamartoma, on his endoscopic, radiologic, surgical and pathologic findings.

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7

Yaka, Mbarek, Anwar Rahali, Mohammed Rebbani, et al. "A CASE OF BRUNNERS GLAND HAMARTOMA PRESENTING AS GASTRIC OUTLET OBSTRUCTION: SURGICAL APPROACH AND LITERATURE REVIEW." International Journal of Advanced Research 13, no. 03 (2025): 213–17. https://doi.org/10.21474/ijar01/20553.

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Brunners gland hamartoma, also known as Brunneroma, is a rare, non-cancerous tumor that represents about 5â€“10% of benign duodenal growths, with an incidence of less than 0.01%. Most cases remain silent, causing no symptoms, but in some instances, they can lead to duodenal obstruction, upper gastrointestinal bleeding, or, more rarely, complications such as biliary fistulation, cholestatic jaundice, or intussusception. Diagnosis is primarily based on imaging techniques and upper gastrointestinal endoscopy. When these hamartomas grow large and cause symptoms, treatment typically involves surgical or endoscopic removal. Here, we present the case of a 50-year-old man with no known medical history who developed symptoms of gastric outlet obstruction. He was diagnosed with a sizable Brunners gland hamartoma and successfully treated with surgery.

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8

Slone, H. W., W. F. Bennett, and J. G. Bova. "MR findings of multiple biliary hamartomas." American Journal of Roentgenology 161, no. 3 (1993): 581–83. http://dx.doi.org/10.2214/ajr.161.3.8352110.

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9

Esseghaier, Sonia, Zohra Aidi, Sana Toujani, and Mohamed Habib Daghfous. "A starry sky: Multiple biliary hamartomas." La Presse Médicale 46, no. 7-8 (2017): 787–88. http://dx.doi.org/10.1016/j.lpm.2017.05.005.

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10

Jáquez-Quintana, Joel O., Erick A. Reyes-Cabello, and Francisco J. Bosques-Padilla. "Multiple Biliary Hamartomas, The ‘‘Von Meyenburg Complexes’’." Annals of Hepatology 16, no. 5 (2017): 812–13. http://dx.doi.org/10.5604/01.3001.0010.2822.

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11

Guiu, Boris, Séverine Guiu, Romaric Loffroy, Jean-Pierre Cercueil, and Denis Krausé. "Multiple Biliary Hamartomas Mimicking Diffuse Liver Metastases." Digestive Surgery 26, no. 3 (2009): 209. http://dx.doi.org/10.1159/000219326.

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12

Taguchi, Takafumi, and Takuhiro Kohsaki. "“Starry Sky” Appearance from Multiple Biliary Hamartomas." New England Journal of Medicine 382, no. 16 (2020): e33. http://dx.doi.org/10.1056/nejmicm1909482.

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13

Dilli, Alper, Umit Yasar Ayaz, Ilhami Yüksel, Cagrı Damar, Sevin Ayaz, and Baki Hekimoglu. "Computed Tomography and Magnetic Resonance Imaging Findings in a Case with Biliary Microhamartomas." Case Reports in Medicine 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/976078.

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Biliary microhamartomas, also known as bile duct hamartomas and von Meyenburg complexes, are benign neoplasms containing cystic dilated bile ducts embedded in fibrous stroma. They develop in hepatobiliary system, do not generally give clinical outcomes, and are detected incidentally. However, they can rarely show malignant transformation. Our aim was to report the contribution of computed tomography, routine magnetic resonance imaging, and magnetic resonance cholangiopancreatography in the diagnosis of biliary microhamartomas in a 61-year-old woman.

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14

Markhardt, B. Keegan, Deborah J. Rubens, Jiaoti Huang, and Vikram S. Dogra. "Sonographic Features of Biliary Hamartomas With Histopathologic Correlation." Journal of Ultrasound in Medicine 25, no. 12 (2006): 1631–33. http://dx.doi.org/10.7863/jum.2006.25.12.1631.

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15

Lev-Toaff, A. S., A. M. Bach, R. J. Wechsler, P. L. Hilpert, Z. Gatalica, and R. Rubin. "The radiologic and pathologic spectrum of biliary hamartomas." American Journal of Roentgenology 165, no. 2 (1995): 309–13. http://dx.doi.org/10.2214/ajr.165.2.7618546.

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16

Zheng, Rong Qin, Masatoshi Kudo, Hirokazu Onda, et al. "Imaging findings of biliary hamartomas (von Meyenburg complexes)." Journal of Medical Ultrasonics 32, no. 4 (2005): 205–12. http://dx.doi.org/10.1007/s10396-005-0051-1.

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17

IHA, HAYATO, YUTAKA NAKASHIMA, YOSHIHIKO FUKUKURA, et al. "Biliary Hamartomas Simulating Multiple Hepatic Metastasis on Imaging Findings." Kurume Medical Journal 43, no. 3 (1996): 231–35. http://dx.doi.org/10.2739/kurumemedj.43.231.

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18

Sato, Shuzo, Hiroshi Watanabe, Tomoyuki Asano, et al. "Biliary hamartomas (von Meyenburg complex) complicated with microscopic polyangiitis." Modern Rheumatology 23, no. 3 (2013): 611–13. http://dx.doi.org/10.3109/s10165-012-0734-6.

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19

PANARO, F., G. GAUFF, G. DONG, G. TESTA, and E. BENEDETTI. "Hepatobiliary and pancreatic: Multiple biliary hamartomas (von Meyenburg complex)." Journal of Gastroenterology and Hepatology 19, no. 4 (2004): 463. http://dx.doi.org/10.1111/j.1440-1746.2003.03422.x.

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20

Liu, Chen-Hua, Rough-Fan Yen, Kao-Lang Liu, Yung-Ming Jeng, Mei-Hsiu Pan, and Pei-Ming Yang. "Biliary hamartomas with delayed 99mTc-diisopropyl iminodiacetic acid clearance." Journal of Gastroenterology 40, no. 5 (2005): 540–44. http://dx.doi.org/10.1007/s00535-004-1581-9.

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21

Thommesen, Niels. "Biliary Hamartomas (von Meyenburg Complexes) In Liver Needle Biopsies." Acta Pathologica Microbiologica Scandinavica Section A Pathology 86A, no. 1-6 (2009): 93–99. http://dx.doi.org/10.1111/j.1699-0463.1978.tb02019.x.

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22

Tarar, Omer, Salman Arif, Saurav Acharya, Carolina Mendez, Robert S. Spira, and Amer Syed. "Multiple Biliary Hamartomas in a Patient With Liver Cirrhosis." American Journal of Gastroenterology 110 (October 2015): S318. http://dx.doi.org/10.14309/00000434-201510001-00725.

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23

Tohmé-Noun, Carla, Dominique Cazals, Roger Noun, Lina Menassa, Dominique Valla, and Valérie Vilgrain. "Multiple biliary hamartomas: magnetic resonance features with histopathologic correlation." European Radiology 18, no. 3 (2007): 493–99. http://dx.doi.org/10.1007/s00330-007-0790-z.

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24

Giambelluca, Dario, Giovanni Caruana, Roberto Cannella, Giuseppe Lo Re, and Massimo Midiri. "The starry sky liver: multiple biliary hamartomas on MR cholangiopancreatography." Abdominal Radiology 43, no. 9 (2018): 2529–30. http://dx.doi.org/10.1007/s00261-018-1490-7.

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25

Tsui, Wilson M. S. "Mow Many Types of Biliary Hamartomas and Adenomas Are There?" Advances in Anatomic Pathology 5, no. 1 (1998): 16–20. http://dx.doi.org/10.1097/00125480-199801000-00002.

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26

Goediker, Juliana, Philipp Schindler, Judit Horvath, et al. "Genetic findings and magnetic resonance imaging of multiple biliary hamartomas." Journal of Hepatology 78 (June 2023): S979. http://dx.doi.org/10.1016/s0168-8278(23)03032-5.

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27

Li, Qian-Qian, Xiao-Zhong Guo, Hong-Yu Li, and Xing-Shun Qi. "Portal hypertension in a patient with biliary hamartomas: A case report." World Journal of Clinical Cases 8, no. 9 (2020): 1745–51. http://dx.doi.org/10.12998/wjcc.v8.i9.1745.

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28

Lin, Su, Zhiyuan Weng, Jing Xu, Ming-Fang Wang, Yue-Yong Zhu, and Jia-Ji Jiang. "A study of multiple biliary hamartomas based on 1697 liver biopsies." European Journal of Gastroenterology & Hepatology 25, no. 8 (2013): 948–52. http://dx.doi.org/10.1097/meg.0b013e32835fb9ee.

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29

Neri, S., B. Mauceri, D. Cilio, C. Sciacca, P. Di Prima, and M. Finazzo. "Biliary hamartomas (von Mayenburg complex): magnetic resonance imaging in a case report." Internal Medicine Journal 34, no. 1-2 (2004): 71–72. http://dx.doi.org/10.1111/j.1444-0903.2004.00521.x.

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30

Ghannei, Olfa, Soumaya Ben Amor, and Mayada Trimech. "Intrahepatic cholangiocarcinoma developing from biliary hamartomas: A case report and literature review." International Journal of Surgery Case Reports 133 (August 2025): 111524. https://doi.org/10.1016/j.ijscr.2025.111524.

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31

Shehi, Elona, Ked Fortuzi, Haider Ghazanfar, Shehriyar Mehershahi, and Bhavna Balar. "Apixaban Causing Hepatic Cystic Bleeding: A Rare but a Life-Threatening Complication." Case Reports in Gastroenterology 15, no. 3 (2021): 904–9. http://dx.doi.org/10.1159/000519276.

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Cystic lesions of the liver are a heterogeneous group of disorders with varied etiology, prevalence, and clinical manifestations. Fibropolycystic liver disease encompasses a spectrum of related liver and biliary tract lesions caused by abnormal embryologic development of the ductal plates. These disorders include congenital hepatic fibrosis, biliary hamartomas, polycystic liver disease (PCLD), choledochal cysts, and Carolis disease. PCLD is arbitrarily defined as a liver that contains &#x3e;20 cysts. Most liver cysts are incidentally found on imaging studies, and the majority of the patients with liver cysts are asymptomatic. Rarely, complications such as compression, infection, and bleeding within the cyst can occur. Under the effect of the increased pressure, the epithelial lining of the cyst undergoes necrosis and sloughing, causing injury of the fragile blood vessels, leading to intracystic bleeding. The bleeding within or from the cyst can be precipitated by anticoagulation. We present a patient with PCLD who developed intracystic bleeding after he was started on apixaban for the prevention of thromboembolism.

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32

Lalosevic, Dusan, Pavle Milosevic, Nada Vuckovic, Vera Uzurov, Zlatibor Andjelkovic, and Matilda Djolai. "Von Meyenburg complex associated with adult polycystic liver disease." Medical review 58, no. 3-4 (2005): 191–95. http://dx.doi.org/10.2298/mpns0504191l.

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Introduction. The von Meyenburg complex (bile duct hamartoma) is a rare developmental disorder, manifested by multiple bile ducts. The polycystic liver disease is a rare congenital anomaly which may remain undiscovered until adult life, occurring more frequently in women. It is mostly asymptomatic, but sometimes surgical intervention is necessary. In the majority of cases, it is combined with cysts in the kidney and, rarely, in other organs as well. The cysts may vary in diameter from I mm to 20 cm, or even more. Case report A 55-year-old woman underwent surgery based on clinical diagnosis: suspected Echinococcus liver cyst. Liver biopsy was performed, and a parenchymal tissue of 6.5x4x3 cm, with a cyst with a diameter of 2.5 cm, was resected. Within the cyst lumen there was a necrotic, mushy, yellow contents. Microscopically examined, it showed plenty of cholesterol crystals. The wall of the cyst consisted of hypocellular connective tissue. In the surrounding liver parenchyma, there were cystical formations of the same structure, measuring 1-2 mm. Also, there were some multiple bile duct hamartomas. The ducts were encircled by a delicate connective tissue. Discussion and conclusion These changes correspond to von Meyenburg complex, i.e. biliary microhamartoma combined with adult polycystic disease. In our case, in the wall of the cyst there were numerous cholesterol crystals, pointing to its retention character and, probably, to the mechanism of its origin. After degeneration of biliary epithelium, the cyst wall grew very thick, due to proliferation of the connective tissue evoked by the aggressive chemical contents of the bile. Frequent development of cholangiocarcinoma within the cyst wall also points to long-term chemical irritation. .

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33

Kostalas, M., P. Jackson, and N. Karanjia. "Brunner’s gland hamartoma: a cause of the double-duct sign." Annals of The Royal College of Surgeons of England 98, no. 6 (2016): e92-e93. http://dx.doi.org/10.1308/rcsann.2016.0131.

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Introduction Brunner’s glands are submucosal glands found in the duodenum. Proliferation of these glands can lead to the formation of Brunner’s gland hamartomas (BGHs), which are uncommon, asymptomatic and usually found incidentally. They are predominantly benign lesions, but instances of malignant transformation have been reported. Case History We describe a rare case in which a periampullary lesion was causing biliary obstruction on a background of weight loss, and was associated with dilatation of the common bile duct and pancreatic duct on computed tomography and magnetic resonance imaging. Further investigation with endoscopic ultrasound and biopsy did not provide a definitive diagnosis. Given the symptoms and findings upon investigations, we proceeded to pylorus-preserving pancreatoduodenectomy. Conclusions This was a rare case in which BGH gave rise to biliary obstruction against a background of weight loss. Due to a high index of suspicion (weight loss and evidence of dilatation of the common bile duct and pancreatic duct), this procedure was justified because the consequences of a missed periampullary cancer far outweighed surgical risks.

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34

Badar, Faraz, Haseeb Siddique, Siddhant Kulkarni, and Ramona Rajapakse. "S2779 Multiple Biliary Hamartomas: A Lesser Known Differential for Cystic Lesions of the Liver." American Journal of Gastroenterology 116, no. 1 (2021): S1159. http://dx.doi.org/10.14309/01.ajg.0000784648.49266.8d.

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35

Neubert, Zachary, Nader Mirhoseni, and R. Daniel Lawson. "A starry sky liver: Klebsiella pneumoniae septic shock caused by infected multiple biliary hamartomas." Gastrointestinal Endoscopy 91, no. 5 (2020): 1205–7. http://dx.doi.org/10.1016/j.gie.2019.12.011.

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36

Berry, Jonathan D., Mark E. Boxer, Hisham I. Rashid, and Paul S. Sidhu. "Case Report: Microbubble Contrast-Enhanced Ultrasound Characteristics of Multiple Biliary Hamartomas (von Meyenberg Complexes)." Ultrasound 12, no. 2 (2004): 95–97. http://dx.doi.org/10.1179/174227104225019490.

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37

Semelka, Richard C., Shahid M. Hussain, Hani B. Marcos, and John T. Woosley. "Biliary hamartomas: Solitary and multiple lesions shown on current MR techniques including gadolinium enhancement." Journal of Magnetic Resonance Imaging 10, no. 2 (1999): 196–201. http://dx.doi.org/10.1002/(sici)1522-2586(199908)10:2<196::aid-jmri14>3.0.co;2-r.

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38

Cooke, J. C., and D. A. P. Cooke. "The appearances of multiple biliary hamartomas of the liver (von Meyenberg complexes) on computed tomography." Clinical Radiology 38, no. 1 (1987): 101–2. http://dx.doi.org/10.1016/s0009-9260(87)80428-2.

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39

Neubert, Zachary, Nader Mirhosseni, and Robert D. Lawson. "1438 A Starry Sky Liver: Klebsiella Pneumoniae Septic Shock Caused by Infected Multiple Biliary Hamartomas." American Journal of Gastroenterology 114, no. 1 (2019): S798. http://dx.doi.org/10.14309/01.ajg.0000595280.37397.70.

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40

Boraschi, Piero, Paola Scalise, Gaia Tarantini, Piero Colombatto, and Francescamaria Donati. "MR imaging features of multiple biliary hamartomas (Von Meyenburg Complex): A pictorial review and differential diagnosis." Journal of Medical Imaging and Radiation Oncology 65, no. 3 (2021): 323–30. http://dx.doi.org/10.1111/1754-9485.13173.

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41

Huang, Yu, Zhou Ye, Yang Kong, Dong-Kai Zhou, Li-Xiong Ying, and Wei-Lin Wang. "Synchronous occurrence of hepatocellular carcinoma and multiple biliary hamartomas mimicking hepatocellular carcinoma with multiple intra-hepatic metastases." Hepatobiliary Surgery and Nutrition 9, no. 4 (2020): 551–54. http://dx.doi.org/10.21037/hbsn.2020.03.01.

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42

Jeon, Gyeong Sik, Joo Sung Sun, Jai Keun Kim, Jae Youn Cheong, Young Bae Kim, and Hee-Jung Wang. "Multiple biliary hamartomas (von Meyenburg complexes) as a solitary focal mass in liver: US, CT and MRI findings." European Journal of Radiology Extra 53, no. 2 (2005): 63–65. http://dx.doi.org/10.1016/j.ejrex.2004.11.008.

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43

Lee, Sang Min, Ki Bae Kim, Joung-Ho Han, Chang Gok Woo, Hee Bok Chae, and Seon Mee Park. "Intrahepatic Cholangiocarcinoma Arising from Biliary Hamartomas in Patients with Recurrent Acute Cholangitis: A Case Report and Literature Review." Korean Journal of Gastroenterology 82, no. 3 (2023): 145–50. http://dx.doi.org/10.4166/kjg.2023.095.

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44

Roderburg, Christoph, Sven H. Loosen, Philipp Bruners, and Tom Luedde. "Die unklare Leberraumforderung." DMW - Deutsche Medizinische Wochenschrift 144, no. 23 (2019): 1651–64. http://dx.doi.org/10.1055/a-0733-6122.

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AbstractUnknown liver lesions represent a common clinical challenge, for example in the context of routine ultrasound examinations of primary care physicians. There are different data on the prevalence of primary liver lesions in the literature. As such, a forensic autopsy series described focal liver lesions in about 50 % of all examined men between 35 and 69 years of age with an increasing incidence for older people. In the diagnostic work-up of unclear liver lesions, a careful distinction between lesions that occur in asymptomatic and healthy individuals and are benign in over 95 % of cases, and lesion found in patients with pre-existing malignant, inflammatory or cirrhotic disease must be made. The main goal in the diagnosis of unclear liver lesions is to prove the benignity of the lesion and to exclude a malignant cause as reliably as possible. In case of benign lesions, an attempt should be made to achieve an exact classification. The most common benign focal liver lesions include liver cysts, focal fatty liver deposition or sparing, haemangiomas, focal calcifications, focal nodular hyperplasia (FNH), nodular regenerative hyperplasia, biliary hamartomas (von-Meyenburg complexes) and hepatocellular adenomas. Abscesses, inflammatory infiltrations or pseudotumors as well as sites of extramedullary haematopoiesis are observed much less frequently. Among the most frequent malignant focal liver lesions are metastases of other tumor entities such as colorectal cancer or pancreatic adenocarcinoma as well as hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCA). Other entities such as hepatic lymphomas or mesenchymal malignant neoplasia are extremely rare.

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45

Alshoabi, Sultan Abdulwadoud, Abdulaziz H. Alkalady, Khaled M. Almas, et al. "The Neoplasms Mimicker: A Pictorial Review of Hydatid Disease." Diagnostics 13, no. 6 (2023): 1127. http://dx.doi.org/10.3390/diagnostics13061127.

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Hydatid cyst is a common name for the larval stage of a tapeworm species of the genus Echinococcus granulosus, which is transmitted from animals to humans via the fecal–oral route. Hydatid cysts predominantly affect the liver (75%), followed by the lung (15%), and they can affect many organs in the human body. Medical imaging modalities are the keystone for the diagnosis of hydatid cysts with high sensitivity and specificity. Ultrasound imaging with high resolution is the first choice for diagnosis, differential diagnosis, staging, establishing a role in interventional management, and follow-up, and it can differentiate Type I hydatid cysts from simple liver cysts. Unenhanced computed tomography (CT) is indicated where or when an ultrasound is unsatisfactory, such as with chest or brain hydatid cysts, when detecting calcification, and in obese patients. Magnetic resonance imaging (MRI) is superior for demonstrating cyst wall defects, biliary communication, neural involvement, and differentiating hydatid cysts from simple cysts using diffusion-weighted imaging (DWI) sequences. According to the phase of growth, hydatid cysts occur in different sizes and shapes, which may mimic benign or malignant neoplasms and may create diagnostic challenges in some cases. Hydatid cysts can mimic simple cysts, choledochal cysts, Caroli’s disease, or mesenchymal hamartomas of the liver. They can mimic lung cystic lesions, mycetoma, blood clots, Rasmussen aneurysms, and even lung carcinomas. Differential diagnosis can be difficult for arachnoid cysts, porencephalic cysts, pyogenic abscesses, and even cystic tumors of the brain, and can create diagnostic dilemmas in the musculoskeletal system.

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46

Riabov, A. B., I. V. Poddubnyi, V. O. Trunov, et al. "Endosurgery in the treatment of children with liver tumors." Russian Journal of Pediatric Surgery 25, no. 5 (2021): 296–302. http://dx.doi.org/10.55308/1560-9510-2021-25-5-296-302.

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Introduction. The basic technique for treating patients with liver neoplasms is a surgical one. Currently, there is a trend to decrease a traumatic impact. One of the options for this is to develop and to implement minimally invasive surgical techniques which make postoperative period and rehabilitation easier.Purpose. To find out the most optimal tactics for surgical treatment of children with liver tumors.Material and methods. In 2014-2020, 26 patients, aged 0-17 years, with liver tumors were treated in Morozov Children’s City Clinical Hospital. 16 boys (61.5%) and 10 girls (38.5%). 17 patients with hepatoblastomas (68%); 2 (8%) in twos - hepatocellular cancer, embryonic liver sarcomas and focal nodular hyperplasias; 1 (4%) by ones - adenoma and hamartomas. In the morphological picture, hepatoplastoma was the most common (16 patients). 25 liver resections were performed; in 5 out of them (20%) (patients aged 3-9 years) minimally invasive technologies were used.Results. Surgical time was significantly shorter in patients who were operated on with laparoscopic access (30–60 minutes), if to compare with laparotomic access (180-270 minutes). The volume of intraoperative blood loss in laparotomic access is more than 5 times larger than in laparoscopic access. In the group of patients operated on with the open access, intraoperative complications were noted in 2 (8%) cases: lethal outcome (4%) and injury of the extrahepatic biliary tract (4%).Conclusion. Laparoscopic techniques reduce surgical time and blood loss. They also prevent complications both during surgery and in the postoperative period, shorten the hospital stay and promote early patient’s mobilization and early enteral feedings as well as early chemotherapy; they reduce pharmpreparation loading and prepare conditions for radical surgery

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47

Valdez Guzman, Bethzi Gisela, Francisco Javier Gonzales Jimenez, Roxana Blanco Villarte, and Rosalia Blanco Villarte. "Hamartomatosis biliar multiple: reporte de caso." Revista Medica 26, no. 1 (2019): 25–29. http://dx.doi.org/10.58296/rm.v26i1.7.

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La hamartomatosis biliar múltiple es una entidad congénita, poco frecuente, asintomática, y en muchas ocasiones no amerita tratamiento, es una malformación hepática benigna, resultado del desarrollo anómalo de la placa ductal biliar, se originan secundarios a una falta de involución de los conductos biliares durante el desarrollo embrionario que ocasiona la aparición de hamartomas biliares o complejos de Von-Meyenburg. Su descubrimiento generalmente es incidental. Se presenta el caso de un paciente de sexo masculino de 39 años de edad, referido al servicio de Gastroenterología por cuadro clínico de larga data caracterizado por dolor abdominal de leve intensidad de tipo intermitente a nivel de hipocondrio derecho e ictericia. Generalmente es un hallazgo casual, excepcionalmente puede aparecer clínica y alteración de las funciones hepáticas como en el presente caso.

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Zen, Yoh, Shintaro Terahata, Shiro Miyayama, et al. "Multicystic biliary hamartoma." Human Pathology 37, no. 3 (2006): 339–44. http://dx.doi.org/10.1016/j.humpath.2005.11.008.

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Alenezi, T., T. Bessissow, and V. Marcus. "A236 ENDOSCOPIC MANAGEMENT OF RARE JEJUNAL SOLITARY PEUTZ-JEGHERS-TYPE POLYP IN AN ELDERLY PATIENT WITHOUT A POLYPOSIS SYNDROME: A CASE REPORT AND REVIEW OF THE LITERATURE." Journal of the Canadian Association of Gastroenterology 6, Supplement_1 (2023): 66. http://dx.doi.org/10.1093/jcag/gwac036.236.

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Abstract Background Solitary Peutz-Jeghers-type polyp (SPJP) is a rare hamartomatous lesion. It is considered as a different entity from Peutz-Jeghers syndrome despite similar histopathological findings. It can be found in the GI tract but rarely in the jejunum. Jejunal SPJP are susceptible to necrosis, ulceration, and intussusception, resulting in GI bleeding or small bowel obstruction. Purpose We describe a case of subacute gastrointestinal bleeding secondary to jejunal SPJP to share our approach to this challenging case using therapeutic endoscopy Method An 81-year-old male patient with a history of atrial fibrillation on warfarin with stable therapeutic INR levels, who presented with 1-week history of melena, generalized fatigue and shortness of breath on exertion and was found to have profound iron deficiency anemia. Esophageal gastroduodenoscopy and colonoscopy failed to identify the source of bleeding; however, double balloon enteroscopy detected a 4 cm polyp with stalk in the proximal jejunum. Endoscopic polypectomy was performed and the whole polyp was removed. Histopathological examination was consistent with Peutz-Jeghers polyp. The oropharyngeal and skin examination was negative for mucocutaneous hyperpigmented macules and the genetic analysis was negative for STK11 mutation. Follow up magnetic resonance enterography and video capsule endoscopy did not reveal any other polypoid lesion in the GI tract. The patient’s symptoms resolved gradually, and his hemoglobin level returned back to normal levels within 6 months. Result(s) To our knowledge this is the first case of endoscopic polypectomy during balloon-assisted enteroscopy for jejunal SPJP. Conclusion(s) Conclusion Solitary Peutz-Jeghers hamartomas are a rare occurrence but should be part of the differential diagnosis for abdominal pain from intussusception, or small bowel bleeding even in elderly patient. Balloon assisted enteroscopy is a valuable technique for the management of solitary small bowel lesions. Please acknowledge all funding agencies by checking the applicable boxes below None Disclosure of Interest None Declared LIVER AND BILIARY DISEASE

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Song, Ji Soo, Sang Jae Noh, Baik Hwan Cho, and Woo Sung Moon. "Multicystic Biliary Hamartoma of the Liver." Korean Journal of Pathology 47, no. 3 (2013): 275. http://dx.doi.org/10.4132/koreanjpathol.2013.47.3.275.

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