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Journal articles on the topic 'Bilirubin/diagnostic use'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Pero, Raffaela, Mariarita Brancaccio, Cristina Mennitti, et al. "Urinary Biomarkers: Diagnostic Tools for Monitoring Athletes’ Health Status." International Journal of Environmental Research and Public Health 17, no. 17 (2020): 6065. http://dx.doi.org/10.3390/ijerph17176065.

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Acute or intense exercise is sometimes related to infections of the urinary tract. It can also lead to incorrect hydration as well as incorrect glomerular filtration due to the presence of high-molecular-weight proteins that cause damage to the kidneys. In this context, our study lays the foundations for the use of a urine test in a team of twelve male basketball players as a means of monitoring numerous biochemical parameters, including pH, specific weight, color, appearance, presence of bacterial cells, presence of squamous cells, leukocytes, erythrocytes, proteins, glucose, ketones, bilirub

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2

Madhavan, Abhilash, and Lakshmana Raman. "A study on the role of raised serum bilirubin levels in acute appendicitis and its outcomes." International Surgery Journal 6, no. 5 (2019): 1561. http://dx.doi.org/10.18203/2349-2902.isj20191870.

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Background: Acute appenidictis is the most common general surgical emergency and early surgical intervention improves outcomes. Despite the increased use of ultrasonography, computed tomography and laparoscopy, the rate of misdiagnosis of appendicitis has remained constant (15.3%) as has the rate of appendicular perforation. Thus, elevated serum bilirubin level will help in the early and accurate diagnosis of acute appendicitis and if so does it have the predictive capacity to warn us about appendicular perforation.Methods: In this study 100 patients were selected as per satisfaction of the in

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3

Tynio, Ya Ya, G. V. Morozova, Yu K. Biryukova, et al. "Toxicity of 13C-labeled linoleic and linolenic acids for diagnostic breath tests." Bulletin of Russian State Medical University, no. 3 (June 30, 2019): 19–24. http://dx.doi.org/10.24075/brsmu.2019.044.

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Noninvasive stable isotope breath tests allow highly accurate and safe estimation of liver and biliary tract function. The aim of this study was to test 13С-labeled linoleic and linolenic acids intended for diagnostic use for acute and subchronic toxicity. The acids were synthesized using the patented method. A single intragastric administration of the tested compounds to experimental BALB/c mice and Wistar rats in the amounts exceeding clinical doses 500 to 2500-fold did not cause animal death. In the subchronic toxicity test, the rats received 5 to 25 times higher doses than recommended for

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4

Oepkes, Dick, and Humphrey HH Kanhai. "Noninvasive assessment of fetal anaemia." Fetal and Maternal Medicine Review 7, no. 3 (1995): 143–57. http://dx.doi.org/10.1017/s0965539500001285.

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In pregnancies complicated by severe red cell alloimmunization, fetal haemolytic anaemia can lead to intrauterine demise as early as 17 weeks' gestation. Intrauterine intraperitoneal blood transfusion, introduced by Liley in 1963, proved to be the first successful example of fetal therapy. The use of this complex procedure, involving X-ray guided puncture of the fetal peritoneal cavity, was limited to fetuses with a gestational age ranging from 24 to 33 weeks. When performed below 26 weeks, survival rates were as low as 16%. The need for intrauterine transfusion was mainly based on determinati

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Montanic, Sendi, Michela Terdoslavich, Uros Rajcevic, et al. "Development and characterization of a novel mAb against bilitranslocase - a new biomarker of renal carcinoma." Radiology and Oncology 47, no. 2 (2013): 128–37. http://dx.doi.org/10.2478/raon-2013-0026.

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Background. Bilitranslocase (TC 2.A.65.1.1) is a bilirubin-specific membrane transporter, found on absorptive (stomach and intestine) and excretory (kidney and liver) epithelia and in vascular endothelium. Polyclonal antibodies have been raised in rabbits in the past, using a synthetic peptide corresponding to AA65-77 of rat liver bilitranslocase, as an antigen. Affinity-purified antibodies from immune sera have been found to inhibit various membrane transport functions, including the bilirubin uptake into human hepatocytes and the uptake of some flavonoids into human vascular endothelial cell

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6

Paducheva, S. V., I. A. Bulatova, A. P. Schekotova, Yu I. Tretyakova, and I. V. Schekotova. "POSSIBILITIES OF USING MELD SCALE FOR DETERMINING HEPATIC CIRRHOSIS DEGREE OF SEVERITY." Perm Medical Journal 34, no. 6 (2017): 40–44. http://dx.doi.org/10.17816/pmj34640-44.

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Aim. To study the possibility of using MELD scale for determining the degree of severity of hepatic cirrhosis (HC) and determine its diagnostic characteristics. Materials and methods. Thirty patients with HC, including 15 patients with compensated HC stage (class A+B) by Child-Pugh scale and 15 persons with decompensated HC (class C), were examined. Total blood bilirubin and creatinine concentrations were assessed, INR and MELD index were calculated. Results. Meld index with use of total bilirubin, creatinine indices and INR is increasing as HC is progressing from 5 at the compensated stage to

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7

Zhirkov, Igor I., Alexander V. Gordienko, Vladimir V. Yakovlev, and Dmitry Y. Serdyukov. "Modern approaches to the diagnosis of alcoholic liver disease." Bulletin of the Russian Military Medical Academy 23, no. 1 (2021): 199–206. http://dx.doi.org/10.17816/brmma63655.

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The article presents up-to-date information about diagnostic methods for one of the most common and socially significant hepatological diseases-alcoholic liver disease. The most frequent clinical manifestations of this pathology are asthenic, dyspeptic, right hypochondrium, cholestatic, neurological, edematous-ascitic and hemorrhagic syndromes. Validated questionnaires are intended for standardized alcohol use screening, the gold standard among which is the AUDIT questionnaire aimed at identifying alcohol use disorders. Most of the physical signs of chronic alcohol abuse are presented in the m

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8

Gunina, L. M., Kazys Mylashyus, and Voitenko V. L. "Physiological and Hereditary Hyperbilirubinemia in Athletes: Role in Reducing Efficiency and Correction Methodology." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 5, no. 5 (2020): 386–93. http://dx.doi.org/10.26693/jmbs05.05.386.

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Under high-intensity loads, the athlete's bodies take place a number of biochemical reactions and physiological processes that can lead to hyperbilirubinemia. The factors that can initiate the onset of this phenomenon include the syndrome of micro-damage muscle, violation of the integrity of erythrocyte membranes, decreased blood pH, malnutrition and increase oxygen demand of the body. Degree of expression of manifestations of physiological bilirubinemia depends on the level of adaptation of the athlete to the physical activities offered. Hyperbilirubinemia in athletes can be one of the compon

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9

Diener-West, Marie, Sandra M. Reynolds, Donna J. Agugliaro, et al. "Screening for Metastasis From Choroidal Melanoma: The Collaborative Ocular Melanoma Study Group Report 23." Journal of Clinical Oncology 22, no. 12 (2004): 2438–44. http://dx.doi.org/10.1200/jco.2004.08.194.

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Purpose To describe the predictive value of liver function tests (LFTs), chest x-ray, and diagnostic imaging for detecting melanoma metastasis during routine follow-up after treatment for choroidal melanoma. Materials and Methods Prospective longitudinal follow-up of patients enrolled onto two randomized trials was conducted by the Collaborative Ocular Melanoma Study (COMS) Group. Baseline and annual or semiannual systemic and laboratory evaluations were performed according to a standard protocol for 2,320 patients enrolled on the COMS. Results COMS patients were screened annually for metastas

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10

Ford, K. A., H. N. Baker, J. G. Baar, et al. "Automated enzyme immunoassay for lutropin with the Abbott IMx analyzer." Clinical Chemistry 35, no. 12 (1989): 2333–35. http://dx.doi.org/10.1093/clinchem/35.12.2333.

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Abstract An automated enzyme immunoassay for human lutropin for use with the Abbott IMx analyzer is described. The assay provides results in approximately 40 min with a sensitivity of 0.25 int. units of LH per liter for up to 23 serum or plasma samples. Cross-reactivity with follitropin (2000 int. units/L) and thyrotropin (2 int. units/L) was negligible; it was 0.016% with human choriogonadotropin (1 X 10(6) int. units/L). There was no interference by high concentrations of bilirubin (0.5 g/L), hemoglobin (7.50 g/L), or triglycerides (13.5 g/L). Intra-, inter-, and total assay CVs were less th

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11

Chala, Inna, Diana Feshchenko, Oksana Dubova, Oksana Zghozinska, Larisa Solodka, and Ihor Sokulskyi. "Blood lipid profile as a diagnostic marker of acute pancreatitis in dogs." Scientific Horizons 24, no. 1 (2021): 14–21. http://dx.doi.org/10.48077/scihor.24(1).2021.14-21.

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Acute pancreatitis is a common non-communicable pathology in dogs, the untimely diagnosis and treatment of which is lethal (27-58% of cases). One of the most common medical tests for acute pancreatitis is to determine the concentration of triglycerides and other fractions of blood lipids. The purpose of the study was to investigate changes in lipid fractions and other biochemical parameters in dogs with acute pancreatitis. For the experiment, two groups of dogs of 10 individuals each were formed. The control group included healthy animals, the experimental group – dogs with acute pancreatitis.

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12

Vaidya, H. C., S. E. Porter, Y. Landt, D. P. Silva, D. N. Dietzler, and J. H. Ladenson. "Quantification of lactate dehydrogenase-1 in serum with use of an M-subunit-specific monoclonal antibody." Clinical Chemistry 34, no. 12 (1988): 2410–14. http://dx.doi.org/10.1093/clinchem/34.12.2410.

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Abstract We have developed a rapid, one-step assay for measuring lactate dehydrogenase-1 (LD-1) activity in serum after extraction of LD-2, LD-3, LD-4, and LD-5 isoenzymes by an immobilized M-subunit-specific monoclonal antibody (D.8.1). In the assay, 100 microL of serum is mixed with 50 microL of a suspension of 0.8-micron-diameter latex particles coated with 30 micrograms of the monoclonal antibody D.8.1, then incubated at room temperature for 5 min. The latex particles, to which LD-2 through LD-5 are bound, are pelleted by centrifugation for 2 min at 12,000 X g, and the LD-1 activity is mea

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13

Smythe, Maureen A., and Greg S. Umstead. "Phenytoin Hepatotoxicity: A Review of the Literature." DICP 23, no. 1 (1989): 13–18. http://dx.doi.org/10.1177/106002808902300102.

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Phenytoin hepatotoxicity is a serious idiosyncratic reaction that occurs in less than one percent of patients. The onset of symptoms occurs early in therapy, usually within the first six weeks. Presenting symptoms often include fever, rash, lymphadenopathy, hepatomegaly, anorexia, and myalgias or arthralgias. Other significant findings that may develop throughout hospitalization are jaundice, periorbital or facial edema, and splenomegaly. The following alterations in liver function tests are associated with phenytoin hepatotoxicity: elevations in serum aminotransferases, lactic dehydrogenase,

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14

Grace, Rachael F., and Wilma Barcellini. "Management of pyruvate kinase deficiency in children and adults." Blood 136, no. 11 (2020): 1241–49. http://dx.doi.org/10.1182/blood.2019000945.

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Abstract Pyruvate kinase deficiency (PKD) is an autosomal-recessive enzyme defect of the glycolytic pathway that causes congenital nonspherocytic hemolytic anemia. The diagnosis and management of patients with PKD can be challenging due to difficulties in the diagnostic evaluation and the heterogeneity of clinical manifestations, ranging from fetal hydrops and symptomatic anemia requiring lifelong transfusions to fully compensated hemolysis. Current treatment approaches are supportive and include transfusions, splenectomy, and chelation. Complications, including iron overload, bilirubin gallst

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15

Gómez-Centurión, Ignacio, Nieves Dorado, Rebeca Bailén, et al. "Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Very Severe Veno-Occlusive Disease after Unmanipulated Haploidentical HSCT with Post-Transplant Cyclophosphamide." Blood 134, Supplement_1 (2019): 1981. http://dx.doi.org/10.1182/blood-2019-125828.

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Background: The use of unmanipulated Haploidentical HSCT (Haplo-HSCT) with post-transplant Cyclophosphamide (PT-Cy) as GVHD prophylaxis has widely extended. Veno-occlusive disease (VOD) is a threatening complication after both autologous and allogeneic HSCT, with high mortality rates despite early medical treatment, including the use of defibrotide. The objective of this study was to describe characteristics and outcomes of patients with refractory very severe VOD after Haplo-HSCT with PT-Cy, treated with TIPS as salvage procedure. Methods: We retrospectively analysed 176 Haplo-HSCT with Cy-po

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16

Kravets, Ye B., Ye A. Biryulina, and Z. G. Mironova. "Hepatobiliary function in children with insulin-dependent diabetes mellitus." Problems of Endocrinology 41, no. 4 (1995): 15–17. http://dx.doi.org/10.14341/probl11453.

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The hepatobiliary system plays the crucial role in the development of metabolic disorders in diabetics. Involvement of the hepatobiliary system may develop at the early stages of diabetes mellitus. The present study was aimed at elucidation of the specific features of bile excretion and production in children with type I diabetes making use of present-day diagnostic methods. Fifty-two patients with type 1 diabetes aged 6 to 15 and 20 healthy controls were examined. Besides common clinical studies, fractionated duodenal probing followed by biochemical analysis of the bile, ultrasonic examinatio

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17

ten Berge, Josianne C. E. M., Mustafa Suker, Marco J. Bruno, et al. "Are a Double Duct Sign or Endoscopic Biopsies Reliable Predictors of Malignancy in Periampullary Lesions." Digestive Surgery 32, no. 4 (2015): 306–11. http://dx.doi.org/10.1159/000380959.

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Aim: To determine the predictive value of a double duct sign (DDS) and endoscopic biopsies to differentiate invasive carcinoma from premalignant lesions. Methods: Two hundred and forty one patients (mean age 65.8; male 55.6%) diagnosed with a periampullary lesion from January 1987 through March 2013 were reviewed retrospectively with regard to background characteristics, histology of endoscopic biopsy, diameter of both common bile duct (CBD) and main pancreatic duct (PD), bilirubin levels and final diagnosis. Results: DDS predicted malignancy with 73% specificity and 72% sensitivity. Endoscopi

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18

Agarwal, Archana M., Jay L. Patel, Adam Clayton, and Noel Scott Reading. "Use of Next Generation Sequencing Panel for Routine Diagnosis of Hereditary Hemolytic Anemias." Blood 132, Supplement 1 (2018): 2325. http://dx.doi.org/10.1182/blood-2018-99-112589.

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Abstract Hereditary hemolytic anemia (HHA) are a heterogeneous group of disorders due to germline mutations of the red cell cytoskeleton (e.g. hereditary spherocytosis (HS) and hereditary elliptocytosis/pyropoikilocytosis (HE/HPP)) or enzyme deficiencies (e.g. glucose 6 phosphate dehydrogenase deficiency (G6PD) and pyruvate kinase deficiency (PKD). Routine morphological and biochemical analysis may be inconclusive in neonates due to the physiological nature of erythroid cell maturation and can also be misleading in transfusion-dependent patients. Additionally, there has been increasing awarene

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19

Leitner, Martina, Christian Büchold, Ralf Pasternack, Nikolaus B. Binder, and Gary W. Moore. "Clinical Validation of an Automated Fluorogenic Factor XIII Activity Assay Based on Isopeptidase Activity." International Journal of Molecular Sciences 22, no. 3 (2021): 1002. http://dx.doi.org/10.3390/ijms22031002.

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Hereditary factor XIII (FXIII) deficiency is a rare autosomal bleeding disorder which can cause life-threatening bleeding. Acquired deficiency can be immune-mediated or due to increased consumption or reduced synthesis. The most commonly used screening test is insensitive, and widely used quantitative assays have analytical limitations. The present study sought to validate Technofluor FXIII Activity, the first isopeptidase-based assay available on a routine coagulation analyser, the Ceveron s100. Linearity was evidenced throughout the measuring range, with correlation coefficients of >0.99,

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Maharaj, Satish, Simone Chang, Karan Seegobin, Marwan Shaikh, and Kamila I. Cisak. "Utility of Procalcitonin in Differentiating Acute Chest Syndrome from Vaso-Occlusive Crisis in Sickle Cell Disease." Blood 136, Supplement 1 (2020): 10–11. http://dx.doi.org/10.1182/blood-2020-143454.

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Background: Acute chest syndrome (ACS) frequently complicates sickle cell disease (SCD) and is a leading cause of hospitalization and mortality. Many factors have been implicated in ACS, including infections, thrombosis, fat and pulmonary emboli. However, a clear etiology is not defined in 50% of the cases and ACS is considered a clinical endpoint for different pathogenic processes (Vichinsky et al 2000). The non-specific nature of ACS makes diagnostic tests challenging, and there are no serum tests clinical used to aid diagnosis. Procalcitonin (PCT) is a prohormone of calcitonin and serum PCT

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Pagaduan, Jayson V., Estella Tam, and Sridevi Devaraj. "Validation of the Procalcitonin Assay on the Abbott Architect i1000." Journal of Applied Laboratory Medicine 3, no. 6 (2019): 936–42. http://dx.doi.org/10.1373/jalm.2018.027904.

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Abstract Background Procalcitonin (PCT) is an emerging biomarker for detecting sepsis. Recently, the US Food and Drug Administration cleared the expanded use of this biomarker for guiding clinicians regarding antibiotic treatment. To our knowledge, there are no published method validations for the Abbott Architect PCT assay. This article will discuss the process of method validation of the B·R·A·H·M·S PCT assay on the Abbott Architect platform. Methods We studied the precision, accuracy, and linearity of the Architect method following the guidance of the Clinical and Laboratory Standards Insti

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Hung, Hao-Chien, Chen-Fang Lee, and Wei-Chen Lee. "Using Rotational Thromboelastometry to Identify Early Allograft Dysfunction after Living Donor Liver Transplantation." Journal of Clinical Medicine 10, no. 15 (2021): 3401. http://dx.doi.org/10.3390/jcm10153401.

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Background: Diagnostic tests for early allograft dysfunction (EAD) after living donor liver transplantation (LDLT) vary widely. We aimed to evaluate the predictive value of rotational thromboelastometry (ROTEM)-derived parameters in EAD. Materials and Methods: A total of 121 patients were reviewed. The definition of EAD proposed by Olthoff et al. included the presence of any of the following at postoperative day 7: bilirubin level ≥ 10 mg/dL, INR ≥ 1.6, or serum AST or ALT levels > 2000 IU/L. All patients underwent ROTEM assay, which consisted of an extrinsically activated thromboelastometr

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Lokich, J. J., R. A. Kane, D. A. Harrison, and W. V. McDermott. "Biliary tract obstruction secondary to cancer: management guidelines and selected literature review." Journal of Clinical Oncology 5, no. 6 (1987): 969–81. http://dx.doi.org/10.1200/jco.1987.5.6.969.

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Malignant biliary tract obstruction (MBTO) due to either primary biliary tract cancer or metastasis to the porta hepatis is a common clinical problem. The most common metastatic tumors causing MBTO in order of frequency are gastric, colon, breast, and lung cancers. Radiographic diagnostic procedures should proceed in a cost-effective sequence from ultrasonography, computerized tomography (CT), percutaneous transhepatic cholangiography (PTHC), and endoscopic retrograde pancreatography with the goal of establishing the site of the biliary tract obstruction. The identification of the site of obst

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Tambaro, Francesco, Dristhi Ragoonanan, Sajad Khazal, et al. "Sinusoidal Obstructive Syndrome Among Pediatric and Adolescent and Young Adult Patients: Analysis of Pediatric EBMT Diagnostic and Severity Criteria at MD Anderson." Blood 134, Supplement_1 (2019): 4495. http://dx.doi.org/10.1182/blood-2019-132085.

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Background: Sinusoidal obstructive syndrome (SOS) is a potentially catastrophic complication of stem cell transplantation (SCT) which disproportionately affects younger patients. The incidence of SOS may vary widely depending on the diagnostic criteria (Baltimore versus Seattle), and delays in initiation of definitive treatment remains the most important predictor of outcome. Recently proposed pediatric diagnostic and severity grading criteria by the European Society of Blood and Marrow Transplantation (EBMT) may offer increased sensitivity and allow for more prompt diagnosis, but the extent t

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25

Lin, CS, GH Chiang, CH Liu, et al. "Comparison of a full-spectrum multi-analyte clinical analyser with six reference instruments using canine and feline blood samples." Veterinární Medicína 62, No. 6 (2017): 342–50. http://dx.doi.org/10.17221/109/2016-vetmed.

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In this study, we report the characterisation of a novel centrifugation and spectrum-integrated veterinary clinical analyser, the AmiShield<sup>TM</sup>, which has been developed for the multiplex measurement of biochemical, electrolyte and immunoassay parameters in a point-of-care testing environment. The aims of this study were to evaluate the analytical performance of the AmiShield<sup>TM</sup> and to compare it with six reference instruments using clinical blood samples. Two hundred and four canine and 120 feline blood samples collected from veterinary teaching hosp

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26

Kolomiytsev, V. I., O. M. Terletskiy, and O. V. Lukavetskiy. "Aspects of diagnosis and treatment of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis." Acta Medica Leopoliensia 26, no. 2-3 (2020): 49–54. http://dx.doi.org/10.25040/aml2020.02-03.049.

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Aim. Developing optimal approaches in the diagnostic algorithm and treatment of patients with acute calculous cholecystitis complicated by oligosymptomatic choledocholithiasis. Material and Methods. The results of treatment of 215 patients with acute calculous cholecystitis complicated by oligosymptomatic choledocholithiasis were analyzed, 166 of which-were studied retrospectively, and 49 - prospectively. Female patients predominated (74.0%); the average age was 56.0±1.06 years. Blood serum biochemistry, transabdominal ultrasound, magnetic resonance cholangiopancreatography, and blood and bile

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Choi, Kyu Young, Bum Sang Lee, Hyo Geun Choi, and Su-Kyoung Park. "Analysis of the Risk Factors Associated with Hearing Loss of Infants Admitted to a Neonatal Intensive Care Unit: A 13-Year Experience in a University Hospital in Korea." International Journal of Environmental Research and Public Health 17, no. 21 (2020): 8082. http://dx.doi.org/10.3390/ijerph17218082.

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Early detection of hearing loss in neonates is important for normal language development, especially for infants admitted to the neonatal intensive care unit (NICU) because the infants in NICU have a higher incidence of hearing loss than healthy infants. However, the risk factors of hearing loss in infants admitted to the NICU have not been fully acknowledged, especially in Korea, although they may vary according to the circumstances of each country and hospital. In this study, the risk factors of hearing loss in NICU infants were analyzed by using the newborn hearing screening (NHS) and the d

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Mukker, Payal, and Smitha Kiran. "Platelet indices evaluation in patients with dengue fever." International Journal of Research in Medical Sciences 6, no. 6 (2018): 2054. http://dx.doi.org/10.18203/2320-6012.ijrms20182287.

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Background: Platelet indices (PIs)-Platecrit, mean platelet volume (MPV) and platelet distribution width (PDW)-are a group of platelet parameters obtained as a part of complete blood count using automated hematology analyzers. Evidence suggests that PIs may have diagnostic and prognostic value in febrile thrombocytopenia. This study aims to understand the profile of PIs in dengue fever. Aims and objectives was to study the platelet indices in patients with dengue fever.Methods: The present study is a retrospective observational study conducted in a tertiary hospital in Kerala. Platelet count,

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Miksad, Rebecca A., Sadahisa Ogasawara, Fang Xia, Marc Mardoche Fellous, and Fabio Piscaglia. "Changes in liver function following real-world transarterial chemoembolization (TACE) in US patients (pts) with hepatocellular carcinoma (HCC): The LiverT study." Journal of Clinical Oncology 36, no. 4_suppl (2018): 441. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.441.

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441 Background: Acute elevations of serum transaminases and bilirubin after TACE are commonly observed in pts with HCC. However, real-world incidence of chronic liver damage after TACE is unclear. LiverT is a retrospective, observational study to assess potential chronic deterioration of liver function of HCC pts after a single TACE in US real-world practice. Methods: Eligible HCC pts underwent index TACE between Jan 1, 2010 and Mar 31, 2016 and did not undergo repeat/additional HCC treatment in the subsequent 90 days. Pts were identified from Optum’s integrated database using standard codes.

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Mauro, Francesca R., Daniele Armiento, Serelina Coluzzi, et al. "Clinical Relevance of an Extended Diagnostic Work-Out in Patients with Primary Autoimmune Amolytic Anemia (AIHA)." Blood 120, no. 21 (2012): 3192. http://dx.doi.org/10.1182/blood.v120.21.3192.3192.

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Abstract Abstract 3192 Autoimmune hemolytic anemia (AIHA) is a rare disease, with an incidence of 1:100,000 for warm AIHA and of 1:1,000,000 for cold AIHA. AIHA can occur without any evidence of an underlying disorder (idiopathic or primary AIHA) or can be diagnosed in association with another disease (secondary AIHA), such as a malignancy, a lymphoproliferative disorder (LD), an autoimmune disorder, an infection. A successful treatment of secondary AIHA is based upon the treatment of the associated disease. In particular, the detection of a possible underlying LD is a relevant issue since a s

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Grushanska, N. G. "The biochemical indicators of a cow organizm at the prevention of microelementosis." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, no. 83 (2018): 183–88. http://dx.doi.org/10.15421/nvlvet8335.

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Correction of cattle feed, taking into account the physiological needs of their organism in the mineral substances of the corresponding biogeochemical zone or the province, where the farm is located, as well as the conditions that accompany the emergence of the deficit, promotes the obtaining of quality livestock products. An urgent task of the present is the search for eco-friendly, non-toxic and highly effective, preventive drugs of complex action, which positively affect the metabolism of mineral substances in the animal organism. The research was carried out on the farm of Kyiv region (cen

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Chen, Christine I., Diego Delgado, Laveena Munshi, et al. "Use of Echocardiography in the Diagnosis of Cardiac AL Amyloidosis - An Analysis of "Presumed" and "Endomyocardial Biopsy-Proven" Disease." Blood 106, no. 11 (2005): 5085. http://dx.doi.org/10.1182/blood.v106.11.5085.5085.

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Abstract Background: The gold standard for diagnosis of cardiac involvement in systemic light chain (AL) amyloidosis is the identification of Congo red amyloid infiltrates on endomyocardial biopsy. As this procedure is invasive, inconvenient, and expensive, the combination of clinical cardiac findings and standard 2D echocardiography (echo) is typically used as a surrogate approach. We sought to evaluate this approach by reviewing clinical and echo parameters in systemic AL amyloid pts with endomyocardial biopsy-proven involvement in comparison to pts with presumed cardiac involvement (echo ab

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Volotko, L. O. "Mathematical Analysis of Evaluating the Homocystein Level in Serum as a Predictor of Meningitis Development in Newborn with Hypoxic-Ischemic Injury of the Central Nervous System." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 5, no. 6 (2020): 102–9. http://dx.doi.org/10.26693/jmbs05.06.102.

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The main reason for the development of neonatal hypoxic-ischemic encephalopathy is inadequate oxygen supply to brain tissue, due to a combination of hypoxemia and ischemia. Hypoxia leads to disruption of oxidative processes and the development of acidosis, decreased energy balance of the cell, an excess of excitatory neurotransmitters, impaired metabolism of glia and neurons. Excess homocysteine can also induce a cascade of events in hippocampal neurons, producing in response to acute bacterial meningitis and accumulating in the central nervous system, reaching neurotoxic levels. Understanding

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Lyman, Gary H., Jeffrey Crawford, Debra Wolff, Eva Culakova, Marek S. Poniewierski, and David C. Dale. "A Prospective Risk Model for Neutropenic Complications in Patients with Malignant Lymphoma." Blood 106, no. 11 (2005): 3328. http://dx.doi.org/10.1182/blood.v106.11.3328.3328.

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Abstract Background: Myelosuppression including severe and febrile neutropenia continues to represent a major cause of dose-limiting toxicity of cancer chemotherapy. Neutropenic complications in cycle 1 have been shown to frequently lead to reduced dose intensity or addition of a myeloid growth factor. A prospective, nationwide study was undertaken to develop and validate risk models for first cycle neutropenic events associated with cancer chemotherapy. Methods: Patients with malignant lymphoma initiating a new chemotherapy regimen have been prospectively registered at 115 randomly selected p

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Mondejar, Rufino, María Mayor Reyes, Enrique Melguizo Madrid, Consuelo Cañavate Solano, and Santiago Pérez Ramos. "Utility of icteric index in clinical laboratories: more than a preanalytical indicator." Biochemia medica 31, no. 2 (2021): 258–66. http://dx.doi.org/10.11613/bm.2021.020703.

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Total bilirubin tests are highly demanded in clinical laboratories. Since icteric index (I-index) has zero cost, we aimed to evaluate its clinical utility and cost-effectiveness to determine if total bilirubin is necessary to be tested. We took into account if haemolysis could interfere to icteric index determination. Retrospectively we reviewed I-index results in two cohorts (43,372 and 8507 non-haemolysed and haemolysed samples, respectively). All determinations were done using Alinity c chemistry analysers (Abbott Diagnostics). Receiver operating characteristic (ROC) curve was used to deter

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Risinger, Mary, Vandy Black, Loan Hsieh, et al. "Evaluation of Phenotype-Genotype Correlation in Two Common PIEZO1 Mutations p.R2456H and p.L2495_E2495dup." Blood 132, Supplement 1 (2018): 1040. http://dx.doi.org/10.1182/blood-2018-99-117299.

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Abstract Hereditary xerocytosis (HX) is a rare autosomal dominant hemolytic anemia caused by mutations in the mechanosensitive cation channel PIEZO1 or, less commonly, in the Ca2+-gated K+ channel KCNN4 (Gardos channel). It is a clinically heterogeneous condition, characterized by erythrocyte dehydration. As erythrocytes traverse narrow capillaries and sinusoids, PIEZO1 is thought to be activated by mechanical stimuli, leading to increased intracellular Ca2+ which then may activate KCNN4, causing K+ efflux and water loss. The p.R2456H and p.L2495_E2496dup PIEZO1 mutations are likely the most c

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Karki, Nabin, Vamsi Kota, Katherine Saunders, et al. "Optimize the Patient to Optimize the Therapy: Role of Prephase Cyclophosphamide in Aggressive Lymphoma." Blood 134, Supplement_1 (2019): 5294. http://dx.doi.org/10.1182/blood-2019-129644.

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Background: Classical Hodgkin lymphoma (CHL) and aggressive non-Hodgkin lymphomas (NHL) are generally considered curable hematologic malignancies but curative strategies typically implore the use of intensive combination chemotherapy regimens. Unfortunately, patients often present with advanced stage disease, high tumor burden, and end-organ damage. Moreover, the presence of multiple comorbidities further complicates the management and prevents the timely initiation of intensive therapeutic regimens. Although prephase chemotherapy is reported in the literature, there is limited data regarding

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Elmaaz, Ahmed, Alberto Antonio Franco Akel, and Regina Belokovskaya. "Bilateral Adrenal Adenomas Attributed to Extrapulmonary Mycobacterium Tuberculosis." Journal of the Endocrine Society 5, Supplement_1 (2021): A118—A119. http://dx.doi.org/10.1210/jendso/bvab048.238.

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Abstract Introduction: Adrenal infections are rare, with the Mycobacterium tuberculosis (MTB) being the most common causative agent in the developing world. MTB usually spreads to the adrenal glands hematogenously where it may be clinically manifested years after systemic infection. Here, we present a case of bilateral adrenal MTB infection associated with MTB peritonitis. Case Presentation: A 46-year-old male, from Ecuador, without significant medical history and no medical follow-up presented to the emergency room with a two-week history of abdominal pain, nausea, diarrhea, and significant w

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Farrukh, Hina, Amina Mehrab, and Abeera Khan. "Adrenal Insufficiency Presenting as Hypoglycemia & Hyponatremia in a Patient With Liver Cirrhosis; Hepatoadrenal Syndrome." Journal of the Endocrine Society 5, Supplement_1 (2021): A111. http://dx.doi.org/10.1210/jendso/bvab048.223.

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Abstract Hepatoadrenal syndrome is described as a progressive impairment in the adrenocortical reserve in advanced liver disease resulting in relative adrenal insufficiency (AI). This can present as critical hypoglycemia and hyponatremia as in the case described. 54 year old male with past medical history of hypothyroidism, pericardial effusion, liver cirrhosis and prior alcohol use disorder presented to the hospital with altered mental status. He felt lethargic and complained of recurrent diarrhea for a month. His blood sugar was 30 mg/dl (n=70–140 mg/dl) for which he received dextrose and hi

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Silapetere, A., J. Spigulis, and I. Saknite. "Development and Experimental Study of Phantoms for Mapping Skin Chromophores." Latvian Journal of Physics and Technical Sciences 51, no. 3 (2014): 58–66. http://dx.doi.org/10.2478/lpts-2014-0020.

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Abstract Skin chromophore phantoms are widely used for better understanding of the light interaction with tissue and for calibration of skin diagnostic imaging techniques. In this work, different phantoms were examined and compared in order to find biologically equivalent substances that are the most promising for this purpose. For mimicking the skin medium and layered structure, a fibrin matrix with epidermal and dermal cell inclusion was used. Synthesized bilirubin, red blood cells and nigrosin were taken as absorbers. For spectral analysis of the developed phantoms a computer-aided multispe

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Larionova, V. B., and A. V. Snegovoy. "Correction possibilities of drug-induced liver toxicity in the treatment of patients with blood system tumors." Oncohematology 15, no. 4 (2020): 65–81. http://dx.doi.org/10.17650/1818-8346-2020-15-4-65-81.

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Background. In modern oncohematology achieved notable success due to the intensification and development of new chemotherapy regimens. However, the side effects of anticancer drugs, due to low selectivity of most of them, are a serious limitation to achieve their maximal therapeutic effect. Although doctors are aware of the possibility of hepatotoxic reactions to various drugs, in clinical practice, the diagnosis of drug-induced liver injury is formulated unreasonably rarely. This speculation is due to several factors: in some cases, the latent course of drug-induced liver injury, often inadeq

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Maharaj, Satish, Simone Chang, Karan Seegobin, Marwan Shaikh, and Kamila I. Cisak. "Utility of Procalcitonin in the Early Diagnosis of Patients with Sickle Cell Disease Presenting with Fever." Blood 136, Supplement 1 (2020): 9. http://dx.doi.org/10.1182/blood-2020-143441.

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Background: Patients with sickle cell disease (SCD) are at increased risk of developing bacterial infections as a result of functional asplenia. Fever, a common symptom in SCD often occurs with other sickle cell related conditions and viral infections. This poses a diagnostic challenge and early use of empiric antibiotics is recommended while awaiting cultures. The widespread administration of antibiotics to all patients with SCD with fever can result in problems such as antibiotic resistance and increased medical costs. An early and reliable biomarker is therefore needed to help distinguish b

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Harris, Andrew C., Rachel Young, Steven M. Devine, et al. "Guidelines for the Standardization of Acute Graft-Versus-Host Disease Clinical Data Collection: An International Consensus Report." Blood 126, no. 23 (2015): 3154. http://dx.doi.org/10.1182/blood.v126.23.3154.3154.

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Abstract Clinical GVHD staging varies between centers and is not agreed upon by independent reviewers (Weisdorf, BBMT 2003). These inconsistencies help explain why promising GVHD treatments from single center studies have not reproduced in multicenter trials. To address this issue, our international GVHD research consortium has developed guidance that has been refined through consensus following case discussions, resulting in uniform and reproducible GVHD clinical symptom reporting. We record all raw target organ symptom data and apply staging based upon this data (Table 1). Only areas of eryt

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Raymond, Frédérique, and Alicia Rico-Lazarowski. "Preliminary Performances of A NEW Generation Assay : VIDAS D-Dimer Exclusion II." Blood 114, no. 22 (2009): 4203. http://dx.doi.org/10.1182/blood.v114.22.4203.4203.

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Abstract Abstract 4203 The diagnostic value of D-dimer (DD) in the exclusion of deep venous thrombosis (DVT) and pulmonary embolism (PE) is well established. With more than 8,000 patients included in prospective management studies, VIDAS D-Dimer assays have been the most extensively assay studied. The aim of this study is to evaluate the analytical performances of a new generation of D-Dimer assay on the VIDAS instrument: VIDAS D-Dimer Exclusion II* (bioMérieux, Marcy l'Etoile, France). VIDAS D-Dimer Exclusion II (DEX2) assay principle combines a two-step enzyme immunoassay sandwich method wi

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Oliver, Carolina, Adriana Peixoto, Cecilia Guillermo, et al. "Outcomes and Prognostic Factors in Critically Ill Patients with Hematologic Malignancies Admitted in an Intensive Care Unit: A Single Center Experience. Hospital De Clínicas, Montevideo, Uruguay." Blood 124, no. 21 (2014): 6017. http://dx.doi.org/10.1182/blood.v124.21.6017.6017.

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Abstract Introduction: patients with hematologic malignancies (HM) admitted in intensive care units (ICU) have been traditionally seen as patients with very poor prognostic. Recently reports have informed that mortality has dropped and nowadays is in the order of 40-60 %, this is still high but closer to mortality in non-malignant patients admitted in an ICU. In an attempt to change this view we perform a study in order to evaluate the results and prognostic factors that contribute to mortality in HM patients who need critical care assistance. Methods: a retrospective study in 62 patients with

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Storm, Mike, Matthew H. Secrest, Courtney Carrington, et al. "Prevalence of Red Cell Pyruvate Kinase Deficiency: A Systematic Literature Review." Blood 134, Supplement_1 (2019): 3513. http://dx.doi.org/10.1182/blood-2019-124381.

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Introduction: Red cell pyruvate kinase deficiency (PKD) is a rare congenital disorder caused by compound heterozygosity or homozygosity for &gt;300 mutations in the PKLR gene. The resulting glycolytic defect can lead to lifelong chronic hemolysis and associated symptoms, including anemia, jaundice, and iron overload. Reports of PKD prevalence vary, likely due to several factors, including PKD rarity, differences in measurement approaches, diagnostic challenges, and variable clinical expression. To understand the prevalence of PKD, we conducted a systematic literature review to identify and

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Vuljanić, Dora, Lora Dukić, Ana-Maria Šimundić, et al. "Analytical verification of 12 most commonly used urine dipsticks in Croatia: comparability, repeatability and accuracy." Biochemia medica 29, no. 1 (2018): 123–32. http://dx.doi.org/10.11613/bm.2019.010708.

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Introduction: Variability among manufacturers of urine dipsticks, respective to their accuracy and measurement range, may lead to diagnostic errors and thus create a serious risk for the patient. Our aims were to determine the level of agreement between 12 most commonly used urine dipsticks in Croatia, examine their accuracy for glucose and total protein and to test their repeatability. Materials and methods: A total of 75 urine samples were used to examine comparability and accuracy of 12 dipstick brands (Combur 10 TestM, ChoiceLine 10, Combur 10 TestUX, ComboStik 10M, ComboStik 11M, CombiScr

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Tang, Nga Yeung, Sarosh Rana, and Kiang-Teck J. Yeo. "Validation of Soluble Fms-Like Tyrosine Kinase-1 (sFlt-1) and Placental Growth Factor (PlGF) Assays on Cobas e602 System." American Journal of Clinical Pathology 154, Supplement_1 (2020): S12—S13. http://dx.doi.org/10.1093/ajcp/aqaa137.022.

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Abstract Background Preeclampsia is a leading hypertensive disorder in pregnant women. The angiogenic biomarkers, soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) ratio, have been shown to be associated with diagnosis and prediction of preeclampsia. The objective of this study is to validate the analytical performance of sFlt-1 and PlGF on the Cobas e602 system (Roche Diagnostics Corporation). Method Intra-day and inter-day precisions for both sFlt-1 and PlGF assays were assessed using quality control materials provided from Roche Diagnostics. The accuracies for b

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Morbieu, Caroline, Thierry Leblanc, Marion Malphettes, et al. "Characteristics and Outcome of DAT-Negative Autoimmune Hemolytic Anemia: Results from a French Multicentre Observational Study." Blood 132, Supplement 1 (2018): 3619. http://dx.doi.org/10.1182/blood-2018-99-116352.

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Abstract Introduction The direct antiglobin test (DAT) is a highly sensitive method (92 to 97%) for the diagnosis of autoimmune hemolytic anemia (AIHA). The diagnosis of DAT-negative AIHA (DN-AIHA) is one of exclusion but the definition of DN-AIHA is not consensual and guidelines on the minimal set of tests that should be performed to rule out other causes of hemolysis are lacking. In this study, we report the baseline characteristics and outcome of a series of both adult and pediatric cases of presumed DN-AIHA based on pre-defined diagnostic criteria. The main characteristics of adult' DN-AIH

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BAJ, JACEK, IWONA ŁUSZCZEWSKA-SIERAKOWSKA, ELŻBIETA RADZIKOWSKA, JACEK SOMPOR, MARCIN MACIEJEWSKI, and ANDRZEJ DĄBROWSKI. "Role of biochemical parameters in predicting histopathological changes at 24 and 48 hours from acute pancreatitis induction." Medycyna Weterynaryjna 75, no. 1 (2020): 6168–2020. http://dx.doi.org/10.21521/mw.6168.

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The aim of the study was to assess the relationships between the degree of changes in concentrations of the biochemical indicators in serum such as: creatinine, uric acid, total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT), lipase, amylase, glucose, iron and magnesium, and histopathological lesions occurring in the pancreas within 24 and 48 hours from the induction of acute pancreatitis (AP). An attempt was made to assess the relation between the changes in concentrations of biochemical indicators and the enhancement of histological lesions in the pancreas based on Sporm

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