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Dissertations / Theses on the topic 'BILIVERDINE'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Peixoto, Mauricio Cupello. "Análise e identificação de produtos do catabolismo de heme nas formas epimastigotas de Trypanosoma cruzi." Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8257.

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O Trypanosoma cruzi, agente etiológico da doença de Chagas, possui um ciclo de vida complexo, deve lidar com diversas condições do ambiente e depende dos hospedeiros para suprir suas necessidades nutricionais. Uma delas é a necessidade de captar a molécula de heme (Fe-protoporfirina IX) que será utilizada como fator de crescimento. Os mecanismos envolvendo o metabolismo de heme são cruciais para a sobrevivência do T. cruzi pois o parasito não possui várias enzimas de biossíntese dessa porfirina e o heme livre pode apresentar citotoxicidade para célula. Na tentativa de perseguir o destino final

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2

Almeida, Fahyme Costa da Silva. "Fatores de Plasmodium falciparum envolvidos na fosforilação de eIF2α em resposta a melatonina." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-17082016-154439/.

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A malária é causada por parasitas Plasmodium falciparum, e embora vários aspectos ainda sejam desconhecidos, é sabido que a regulação do ciclo intraeritrocítico é crítica para a compreensão do ciclo celular e patogênese. A melatonina modula o ciclo de P. falciparum promovendo a sincronização, mas, o mecanismo de transdução de sinal é parcialmente caracterizado, envolvendo variações citosólicas de cálcio, AMPc e ativação da PKA. Modificações pós-traducionais participam na via de sinalização, e diversas proteínas quinase podem estar envolvidas na sinalização por melatonina. eIF2α fosforila

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Santos, Eduardo Alves dos. "Papel do IP3 na transdução de sinal e função da heme oxigenase em Plasmodium falciparum." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-20032014-174955/.

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Demonstramos que o P. falciparum dentro do eritrócito é capaz de usar a via de sinalização celular dependente do inositol trifosfato (IP3). Investigamos os estoques de Ca2+ intracelular sensíveis ao IP3 neste parasita e a sensibilidade ao IP3 em diferentes estágios no ciclo intraeritrocítico. Demonstramos que o hormônio melatonina é capaz de aumentar a concentração de IP3 neste parasita. Com o uso de uma coluna de afinidade ao IP3 tentamos encontrar proteínas candidatas ao receptor de IP3 em P. falciparum. Este trabalho também estuda a enzima heme oxigenade de P. falciparum (PfHO). Testamos a

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4

Gomes, Antoniella Souza. "Efeito protetor da via hemeoxigenase 1/ biliverdina/ CO em modelos de lesões gástricas em camundongos : papel da guanilato ciclase solúvel (GCS) e DA no sintase (NOS)." reponame:Repositório Institucional da UFC, 2009. http://www.repositorio.ufc.br/handle/riufc/2680.

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GOMES, Antoniella Souza. Efeito protetor da via hemeoxigenase 1/Biliverdina/CO em modelos de lesões gástricas em camundongos : papel da guanilato ciclase solúvel (GCS) e da sintase (NOS). 2009. 200 f. Tese (Doutorado em Farmacologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2009.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-05-24T14:19:46Z No. of bitstreams: 1 2009_tese_asgomes.pdf: 2256560 bytes, checksum: 9d8cc277feea50867d84d91dacad0870 (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-05-30T14:16:19Z (GMT)

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5

Russell, Malcolm Peter. "Resonance raman spectroscopic studies of bilirubin and biliverdin." Thesis, University of York, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358273.

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6

Coulthurst, Sandra Jane. "A spectroscopic study of bilirubin and biliverdin and their complexes with proteins." Thesis, University of York, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323607.

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7

Rodrigues, Pedro Mendes de Azambuja. "Heme oxigenase-1 como um alvo terapêutico na sepse o papel da biliverdina." reponame:Repositório Institucional da FIOCRUZ, 2007. https://www.arca.fiocruz.br/handle/icict/12864.

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Made available in DSpace on 2016-02-26T13:34:40Z (GMT). No. of bitstreams: 2 pedro_rodrigues_ioc_dout_2007.pdf: 495339 bytes, checksum: 0791930416bc740981dac64b0ead8959 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2016-01-13<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil<br>A heme oxigenase-1 (HO-1), uma enzima induzida sob diversas condições de estresse celular, cataboliza o heme em monóxido de carbono (CO), biliverdina (convertida posteriormente a bilirrubina) e ferro livre. A deficiência dessa enzima

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8

Kawasaki, Yukie. "Scalable Bio-Production of High Value Products in Bacteria." DigitalCommons@USU, 2015. https://digitalcommons.usu.edu/etd/4609.

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Biliverdin IXα is a green bile pigment produced by enzymatic cleavage of a tetrapyrrole ring of heme by heme oxygenase. While biliverdin IXα is emerging as an effective cytoprotectant, the conventional method for producing biliverdin IXα by chemical conversion of animal bile is not suitable for large scale production. A novel scalable production method was pursued via bacterial fermentation. Recombinant Escherichia coli strains were obtained by sequence optimization and plasmid transformation of a cyanobacterial heme oxygenase gene. Further strain development was done by plasmid overexpression

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9

Clark, William D. "The isolation, identification and exploration of the biophysiological significance of plasma biliverdin in the ballan wrasse (Labrus bergylta)." Thesis, University of Stirling, 2016. http://hdl.handle.net/1893/25380.

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Labrus bergylta (ballan wrasse) have recently emerged as a key resource to aquaculture through proven efficacy in controlling infestations of sea lice (Leclercq et al., 2014a). However, due to complex ecology, and a complete lack of sexual dimorphism gender identification endures as a key restriction to optimising broodstock management therefore male selection and establishing optimal sex ratios is difficult (Talbot et al., 2012). L. bergylta, are noted to demonstrate unusually coloured plasma ranging in hue from green to blue with the haem catabolite biliverdin established as the causal pigme

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10

Aga, Rubina Gul. "Studies of the Chemistry of S-Nitrosothiols and the Interactions of Biliverdin and Bilirubin with Selected Reactive Nitrogen Compounds." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487754.

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S-nitrosothiols undergo homolytic decomposition in aqueous solution to release NO and are also able to transfer the NO+ group to other thiolates to generate Snitrosothiols, which may undergo more facile homolysis. These reactions are probably of some significance in intracellular processes, while the use of S-nitrosothiols as sources of NO is well known, although the possibility of transnitrosation has not always been considered. However, it is possible that some of the biochemistry of Snitrosothiols takes place in cell walls and that their lipophilicity is an important factor in controlling r

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11

Grangeiro, Niedja Maruccy Gurgel da Cruz. "InteraÃÃo das vias da ciclo-oxigenase-2 e da hemeoxigenase-1 / biliverdina / monÃxido de carbono no controle da nocicepÃÃo e da inflamaÃÃo." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5372.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>FundaÃÃo de Amparo Ã Pesquisa do Estado do CearÃ<br>IntroduÃÃo: A via da hemeoxigenase-1 (HO-1) possui aÃÃes antioxidantes. Por outro lado, a ciclo-oxigenase 2 (COX-2) estÃ envolvida na patogÃnese de muitas doenÃas inflamatÃrias e sua inibiÃÃo seletiva reduz eventos inflamatÃrios sem efeitos gÃstricos. Entretanto, ensaios clÃnicos demonstraram que os inibidores seletivos de COX-2 estÃo associados com efeitos cardiovasculares. Objetivo: Avaliar a interaÃÃo entre as vias da HO-1/BVD/CO e da COX-2 no controle da nocicepÃÃo e da inflam

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12

Grangeiro, Niedja Maruccy Gurgel da Cruz. "Interação das vias da ciclo-oxigenase-2 e da hemeoxigenase-1 / biliverdina / monóxido de carbono no controle da nocicepção e da inflamação." reponame:Repositório Institucional da UFC, 2010. http://www.repositorio.ufc.br/handle/riufc/16292.

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GRANGEIRO, N. M. G. C.Interação das vias da ciclo-oxigenase-2 e da hemeoxigenase-1 / biliverdina / monóxido de carbono no controle da nocicepção e da inflamação. 105 f. Dissertação (Mestrado em Biotecnologia) - Curso de Medicina - Campus de Sobral, Universidade Federal do Ceará, Sobral, 2010.<br>Submitted by Djeanne Costa (djeannecosta@gmail.com) on 2016-04-18T15:09:43Z No. of bitstreams: 1 2010_dis_nmdcgrangeiro.pdf: 78365295 bytes, checksum: 06083dff95e31ddb10ff699bf2fa0f20 (MD5)<br>Approved for entry into archive by Djeanne Costa (djeannecosta@gmail.com) on 2016-04-18T15:29:16Z (GMT) No.

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13

Chaves, HellÃada Vasconcelos. "Modelo experimental de hipernocicepÃÃo facial e artrite na articulaÃÃo temporomandibular induzida por zymosan em ratos e estudo da via da hemeoxigenase-1/biliverdina/monÃxido de carbono." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14205.

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nÃo hÃ<br>DisfunÃÃo temporomandibular (DTM) Ã um distÃrbio relacionado Ã funÃÃo do sistema mastigatÃrio que acomete as articulaÃÃes temporomandibulares (ATM), os mÃsculos mastigatÃrios e/ou estruturas associadas, embora os mecanismos envolvidos na inflamaÃÃo e na dor da ATM sejam pouco compreendidos. Apesar do grande interesse que hemeoxigenase-1 (HO-1) tem recebido nos Ãltimos anos e a forte evidÃncia dos seus efeitos citoprotetores e anti-inflamatÃrios, o papel da via HO-1/bilivedina (BVD)/monÃxido de carbono (CO) na dor e inflamaÃÃo da ATM ainda nÃo foi estudado. O objetivo deste estudo Ã e

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14

Chaves, Hellíada Vasconcelos. "Modelo experimental de hipernocicepção facial e artrite na articulação temporomandibular induzida por zymosan em ratos e estudo da via da hemeoxigenase-1/biliverdina/monóxido de carbono." reponame:Repositório Institucional da UFC, 2012. http://www.repositorio.ufc.br/handle/riufc/12260.

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CHAVES, Hellíada Vasconcelos. Modelo experimental de hipernocicepção facial e artrite na articulação temporomandibular induzida por zymosan em ratos e estudo da via da hemeoxigenase-1/biliverdina/monóxido de carbono. 2012. 165 f. Tese (Doutorado em Ciências Médicas) – Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2012.<br>Submitted by denise santos (denise.santos@ufc.br) on 2015-05-19T11:21:23Z No. of bitstreams: 1 2012_tese_hvchaves.pdf: 3886855 bytes, checksum: a2af0fa3b6c2cdbc9c9d453ed4e323fa (MD5)<br>Approved for entry into archive by denise santos(denise.santos@ufc.br

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15

Gomes, Antoniella Souza. "Efeito protetor da via hemeoxigenase 1/ BILIVERDINA/ CO em modelos de lesÃes gÃstricas em camundongos â papel da guanilato ciclase solÃvel (GCS) e da no sintase (NOS)." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=6887.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Objective: To evaluate the protective effect of the heme-oxygenase 1 (HO-1)/biliverdin/CO pathway in models of gastropathy in mice, evaluating the role of the soluble guanylate cyclase (GCs) and of the constitutive NOS in this event. Methods: Protocol 1: Mice were pre-treated with hemin (HO-1 inducer; 1,3,10 mg/Kg, i.p.), biliverdin (HO-1 product; 1,3 or 10 mg/Kg., i.p.), DMDC (CO donor; 2.5, 7.5, 12.5 or 10 Âmol/Kg, i.p.) or ZnPP IX (HO-1 antagonist; 0,3, 1 or 3 mg/kg. i.p.), one hour before, gastric damage was induced by etha

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16

Zhang, Zhaoshu. "INCREASE OF BASAL OXIDATIVE STRESS LEVELS AND IMPAIRMENT OF HEME OXYGENASE-1/BILIVERDIN REDUCTASE POST-TRANSLATIONAL MODIFICATION BY THE DEFECT OF PARKINSON-RELATED GENE OF PINK1." UKnowledge, 2014. http://uknowledge.uky.edu/chemistry_etds/40.

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Parkinson disease (PD) is the most common movement disorder and the second most common neurodegenerative disease. PINK1, PTEN-induced kinase 1, functions as a serine/threonine kinase as well as a protector of mitochondrial function. Mutations in PINK1 gene result in either mitochondria dysfunction or disruption of kinase signaling pathways involved in the pathogenesis of PD. In this thesis, oxidative stress levels were examined in the brain of PINK1 knockout mice, and also how heme oxygenase-1 and biliverdin reductase are affected in brain of PINK1 knockout mice. In addition, posttranslational

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17

Jones, Landon R. "Calcium dynamics affecting egg production, skeletal integrity, and egg coloration in ring-necked pheasants Phasianus colchicus /." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd2211.pdf.

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18

Boone, Katelyn. "Purification and Characterization of Blue and Green Chromoprotein Pigments from the Integument of Male Darters in the Genus Etheostoma." 2011. http://digital.library.duq.edu/u?/etd,154696.

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Unlike most other vertebrates, many species in the genus Etheostoma do not utilize structural refraction to display blue or green color. Instead, blue and green mating coloration exhibited by male rainbow darters (E. caeruleum) and male greenside darters (E. blennioides) results from the presence of true chromoprotein pigments. This study was conducted in order to extract, purify, characterize, and compare these novel pigments. Pigments were extracted in aqueous buffer and partially purified by ammonium sulfate fractionation and gel filtration chromatography. Final purification consisted o

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19

Kubíčková, Kristýna. "Úloha oxidačního stresu v jaterní kancerogenezi." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-436707.

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This thesis focuses on the importance of heme catabolic pathway in hepatic carcinogenesis. Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumour. It is primarily caused by hepatic cirrhosis or chronic viral hepatitis. Hepatic carcinogenesis is associated with increased oxidative stress. Thus, our study aimed to assess the expression of the genes involved in the homeostasis of oxidative stress in patients with HCC. The study was performed on patients with primary HCC (n = 29) and control subjects (n = 11), gene expressions of heme oxygenase 1 (HMOX1), biliverdin reduc

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20

Subhanová, Iva. "Katabolická dráha hemu u chronické hepatitidy C." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-327399.

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This thesis focuses on the importance of the heme catabolic pathway in chronic hepatitis C (HCV). The aim is mainly to investigate, whether expresion/activity of key enzymes of the heme catabolic pathway, heme oxygenase (HMOX) and biliverdin reductase (BLVRA) in the liver and blood (study A) or promoter variations of HMOX1 and UDP- glucuronosyltransferase (UGT1A1) (study B) may be associated with the progression of fibrosis and may also predict antiviral treatment outcome in patients chronically infected with HCV. We set up a new sensitive method to quantify HMOX activity by reduction gas chro

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21

Štícha, Martin. "Využití hmotnostní spektrometrie pro analýzu biologicky aktivních a klinicky významných látek." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-352073.

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- 8 - ABSTRACT (EN) The thesis is submitted as a commented set of reviewed publications documenting and depicting the possibilities of mass spectrometry in the field of chemical, biological and pharmaceutical research; namely for the purposes of structure elucidation of selected organometallic complexes, analyses of drugs and their metabolites, monitoring of important biological markers. In course of experimental work, the following objectives were studied and solved:  Proposal and realization of micro-scale preparation of selected rhenium complexes with aromatic ligands, utilizing tetrabutya

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