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Journal articles on the topic 'BIM 4 D'

Author: Grafiati

Published: 8 September 2021

Last updated: 29 July 2025

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1

Zdorovenko, Evelina Leont’evna, Alexander Stepanovich Shashkov, Alexandra Alexeevna Kadykova, et al. "Structures of cell-wall glycopolymers of Lactococcus lactis BIM B-1024." EuroBiotech Journal 1, no. 1 (2017): 41–45. http://dx.doi.org/10.24190/issn2564-615x/2017/01.07.

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Abstract Glycopolymers of two types were isolated from the cell wall of Lactococcus lactis BIM B-1024 by stepwise extraction with cold and hot 10% CCl3CO2H and separated by anion-exchange gel chromatography. The following structures of the glycopolymers were established by sugar analysis, dephosphorylation with 48% HF, 1D and 2D NMR spectroscopy, and ESI-MS: β-D-Galp-(1→4)-β-D-Glcp-(1→6)┐ →4)-β-D-Galp-(1→4)-β-D-Glcp-(1→4)-α-D-Glcp-(1→ PSI β-D-Glcp-(1→3)┐ →60-α-D-GalpNAc-(1→3)-β-D-GalpNAc-(1→5)-Rib-ol-1-P-(O→ PSII β-D-Glcp-(1→4)┘ Polysaccharides with the same or similar structures to PSI have b

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Runceanu, L. S., and N. Haala. "INDOOR MESH CLASSIFICATION FOR BIM." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-4 (September 19, 2018): 535–39. http://dx.doi.org/10.5194/isprs-archives-xlii-4-535-2018.

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<p><strong>Abstract.</strong> This work addresses the automatic reconstruction of objects useful for BIM, like walls, floors and ceilings, from meshed and textured mapped 3D point clouds of indoor scenes. For this reason, we focus on the semantic segmentation of 3D indoor meshes as the initial step for the automatic generation of BIM models. Our investigations are based on the benchmark dataset ScanNet, which aims at the interpretation of 3D indoor scenes. For this purpose it provides 3D meshed representations as collected from low cost range cameras. In our opinion such RGB-

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Afzal, Muneeb, and Muhammad Tariq Shafiq. "Evaluating 4D-BIM and VR for Effective Safety Communication and Training: A Case Study of Multilingual Construction Job-Site Crew." Buildings 11, no. 8 (2021): 319. http://dx.doi.org/10.3390/buildings11080319.

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Effective safety management is a key aspect of managing construction projects. Current safety management practices are heavily document-oriented that rely on historical data to identify potential hazards at a construction job site. Such document-bound safety practices are prone to interpretative and communication errors in multilingual construction environments, such as in the United Arab Emirates (UAE). Applications of Building Information Models (BIM) and Virtual Reality (VR) are claimed to improve hazards identification and communication in comparison to 2-D static drawings by simulating jo

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Danalev, Dancho, Ivan Iliev, Stefan Dobrev, et al. "Synthesis, Antiproliferative Effect and In Silico LogP Prediction of BIM-23052 Analogs Containing Tyr Instead of Phe." Pharmaceutics 15, no. 4 (2023): 1123. http://dx.doi.org/10.3390/pharmaceutics15041123.

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(1) Background: Hydrophobicity (or lipophilicity) is a limiting factor in the ability of molecules to pass through cell membranes and to perform their function. The ability to efficiently access cytosol is especially important when a synthetic compound has the potential to become a drug substance. D-Phe-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr-NH2 (BIM-23052) is a linear analog of somatostatin with established in vitro GH-inhibitory activity in nanomolar (nm) concentrations and high affinity to different somatostatin receptors. (2) Methods: Series of analogs of BIM-23052 were synthesized where Phe residu

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Rached, Ishraq, Rafika Hajji, Tania Landes, and Rashid Haffadi. "Deep Learning Based Semantic Segmentation for BIM Model Generation from RGB-D Sensors." ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences X-4/W5-2024 (June 27, 2024): 271–79. http://dx.doi.org/10.5194/isprs-annals-x-4-w5-2024-271-2024.

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Abstract. RGB-D sensors offer a low-cost and promising solution to streamline the generation of BIM models. This paper introduces a framework designed to automate the creation of detailed and semantically rich BIM models from RGB-D data in indoor environments. The framework leverages advanced computer vision and deep learning techniques to overcome the challenges associated with traditional, labour-intensive BIM modeling methods. The results show that the proposed method is robust and accurate, compared to the high-quality statistic laser scanning TLS. Indeed, 58% of the distances measured bet

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Pilipchuk, T. A., A. E. Akhremchuk, and E. I. Kаlаmiуets. "Molecular-genetic structure of <i>Pseudomonas phage</i> BIM BV-45 D." Proceedings of the National Academy of Sciences of Belarus, Biological Series 67, no. 2 (2022): 190–96. http://dx.doi.org/10.29235/1029-8940-2022-67-2-190-196.

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Full nucleotide sequence of bacteriophage Pseudomonas phage BIM BV-45 D – active component of biopesticide Multiphage intended for control of crop bacterial diseases caused by Pseudomonas syringae was analyzed. It was found that phage genome is represented by linear double-stranded DNA sized 40383 b. p. (average GC contents equals 58 %), comprising 46 open reading frames, including 13 described in genomes of closely related phages. 4 control sequences typical for bacterial genes recognized by sigma factor (σ70) of RNA polymerase were detected, specific phage promoters were not localized. The i

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7

Tschickardt, Thomas, Daniel Krause, and Jan Akkermann. "Entwicklung und Evaluation von BIM-4-D-Methoden am Beispielprojekt Gateway Gardens Los 2, Frankfurt/Main." Bautechnik 95, no. 7 (2018): 453–62. http://dx.doi.org/10.1002/bate.201800026.

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8

Liu, Mei. "Investigation of the Impact of BIM&IPD on Change Orders Using Bayesian Network Method." Applied Mechanics and Materials 397-400 (September 2013): 2064–68. http://dx.doi.org/10.4028/www.scientific.net/amm.397-400.2064.

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Change orders present one of the largest sources of cost growth on building construction projects and have negative impact on productivity, labor efficiency and building environment. Building Information Modeling (BIM) is proved a high technology that greatly benefits both design and construction, greatly promoting the design visualization and construction 4-D modeling. Driven by BIM, Integrated Project Delivery (IPD) emphasizes communication in the collaborative process by avoiding adversarial or counter-productive professional relationships to reduce waste and rework. If BIM&IPD can be p

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Kapuriya, K. G., S. D. Faldu, H. R. Topiya, A. L. Ganure, S. K. Moitra, and L. J. Patel. "Synthesis and In Vitro Evaluation of Novel 4-methyl-6-(1-methyl-1H-benzo[d] imidazol-2-yl)-2-propyl-1H-benzo[d]imidazoleDerivatives as Cytotoxic Agents." International Journal of Drug Design and Discovery 3, no. 3 (2025): 840–46. https://doi.org/10.37285/ijddd.3.3.3.

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In the present study, a novel series of substituted Bis benzimidazole derivatives were synthesized and characterized by means of IR, H-NMR, Mass spectral and physical analysis. The compounds were screened for in vitro cytotoxic activity by XTT based cell viability assay method by using two human cancer cell line PC-3 and VERO. All synthesis compounds exhibited significant activity against cancer cell line after 48 hours has comparable with standard drug doxorubicin. Among all compound screened, one compound bim-4 was found to be most potent.

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Ali, Mariawati Binti. "A Framework of Contractual Protocol for Building Information Modelling (BIM) Implementation in Water Treatment Plant Projects." IOP Conference Series: Earth and Environmental Science 1303, no. 1 (2024): 012033. http://dx.doi.org/10.1088/1755-1315/1303/1/012033.

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Abstract Building Information Modelling (BIM) is becoming a comprehensive collaborative process in the construction industry. Since the introduction of BIM in Malaysia in 2009, the technology adoption rate is slow when compared to other countries of the world. Most of the construction companies in Malaysia have an insight on the BIM concept but are yet to implement it in the management of their construction projects. By the year 2020, the Malaysian government will make BIM mandatory, this makes it important to carry out research on the possible applications of the technology. The aim for this

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Spiegelhalter, Thomas. "ACHIEVING THE NET-ZERO-ENERGY-BUILDINGS “2020 AND 2030 TARGETS” WITH THE SUPPORT OF PARAMETRIC 3-D/4-D BIM DESIGN TOOLS." Journal of Green Building 7, no. 2 (2012): 74–86. http://dx.doi.org/10.3992/jgb.7.2.74.

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Adelia, Lusieta, Irika Widiasanti, and Arris Maulana. "Penyusunan E-Modul Pelatihan BIM pada Jabatan Kerja Juru Gambar BIM Jenjang 3 Berbasis SKKNI No. 3 Tahun 2023." Jurnal Ilmiah Global Education 6, no. 1 (2025): 108–15. https://doi.org/10.55681/jige.v6i1.3619.

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This research aims to develop training materials for Competency-Based Training E-Modules for Level 3 BIM Draftsman in accordance with SKKNI No. 3 of 2023. The research was conducted using the Research and Development (R&D) method of the 4D model which includes four main stages: (1) Define, (2) Design, (3) Development, and (4) Dissemination. Data collection techniques were carried out with questionnaires as an instrument of feasibility assessment by three material experts, three media experts, and users, additionally pre-test and post-test to measure effectiveness in the limited trial phase

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Cheechana, Nathaporn, Wachara Benchaphanthawee, Natthapol Akkravijitkul та ін. "Organocatalytic Ring-Opening Polymerization of ε-Caprolactone Using bis(N-(N′-butylimidazolium)alkane Dicationic Ionic Liquids as the Metal-Free Catalysts: Polymer Synthesis, Kinetics and DFT Mechanistic Study". Polymers 13, № 24 (2021): 4290. http://dx.doi.org/10.3390/polym13244290.

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In this work, we successfully synthesized high thermal stable 1,n-bis(N-(N′-butylimidazolium)alkane bishexafluorophosphates (1,n-bis[Bim][PF6], n = 4, 6, 8, and 10) catalysts in 55–70% yields from imidazole which were applied as non-toxic DILs catalysts with 1-butanol as initiator for the bulk ROP of ε-caprolactone (CL) in the varied ratio of CL/nBuOH/1,4-bis[Bim][PF6] from 200/1.0/0.25–4.0 to 700/1.0/0.25–4.0 by mol%. The result found that the optimal ratio of CL/nBuOH/1,4-bis[Bim][PF6] 400/1.0/0.5 mol% at 120 °C for 72 h led to the polymerization conversions higher than 95%, with the molecul

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Mahmood, Ali, and Sepehr Abrishami. "BIM for lean building surveying services." Construction Innovation 20, no. 3 (2020): 447–70. http://dx.doi.org/10.1108/ci-11-2019-0131.

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Purpose The purpose of this paper is to determine whether the implementation of building information modelling (BIM) concepts of the various processes involved in building surveying practice can lead to a reduction in waste. In turn leading to a synergy between BIM functionalities and lean production concepts. Design/methodology/approach To verify and validate the existence of this synergy between the two methods in building surveying, evidences were gathered from previous literature that supports these interactions. Next, a questionnaire was conducted for the purpose of identifying new intera

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Indah Mayang Sari, Regita, Tuti Iriani, and Rosmawita Saleh. "THE DEVELOPMENT OF E-MODULE SOFTWARE AND BIM-BASED BUILDING INTERIOR DESIGN." Jurnal PenSil 11, no. 3 (2022): 206–13. http://dx.doi.org/10.21009/jpensil.v11i3.26298.

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This research aims to develop e-module for Software and Building Interior Design subjects based on Building Information Modeling (BIM) using the ArchiCAD software. The method used was the research and development method (R&D) from Thiagarajan which has 4 stages, namely define, design, develop, and dissemination. The data analysis technique uses instruments for expert appraisal. The developmental testing of e-module is used to determine the effectiveness of using e-modules software and BIM-based building interior design by users. This test was carried out by two selected schools, which cons

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Пименов, С. И. "Analysis of Modern Software for Virtual Construction (4D Modeling)." НАУЧНЫЙ ЖУРНАЛ СТРОИТЕЛЬСТВА И АРХИТЕКТУРЫ, no. 3(67) (September 22, 2022): 92–104. http://dx.doi.org/10.36622/vstu.2022.67.3.009.

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Постановка задачи. В связи с уникальностью каждого объекта капитального строительства и разнообразием программных комплексов цифрового моделирования представляет научно-практический интерес обоснование целесообразности применения того или иного программного комплекса. Результаты. Приводится анализ функциональных возможностей популярных программных комплексов для разработки цифровых информационных моделей на этапе строительства по технологии BIM и ТИМ ( Navisworks Manage , Bexel Manager , Synchro 4 D Pro , Asta Powerproject BIM , DELMIA ). Установлены и описаны их основные недостатки и преимуще

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17

Li, Yaxin, Wenbin Li, Shengjun Tang, Walid Darwish, Yuling Hu, and Wu Chen. "Automatic Indoor as-Built Building Information Models Generation by Using Low-Cost RGB-D Sensors." Sensors 20, no. 1 (2020): 293. http://dx.doi.org/10.3390/s20010293.

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To generate indoor as-built building information models (AB BIMs) automatically and economically is a great technological challenge. Many approaches have been developed to address this problem in recent years, but it is far from being settled, particularly for the point cloud segmentation and the extraction of the relationship among different elements due to the complicated indoor environment. This is even more difficult for the low-quality point cloud generated by low-cost scanning equipment. This paper proposes an automatic as-built BIMs generation framework that transforms the noisy 3D poin

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Silva, J. P., J. P. Pereira, and J. Santos. "DIGITAL TWIN 3D PLATFORM FOR COLLABORATIVE REPRESENTATION AND EDITING OF IFC DOCUMENTS APPLIED TO THE BIM METHODOLOGY." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVIII-4/W1-2022 (August 6, 2022): 411–18. http://dx.doi.org/10.5194/isprs-archives-xlviii-4-w1-2022-411-2022.

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Abstract. Currently , the Architecture, Engineering, Construction (AEC) sector lacks tools for digitization, being forced to resort to proprietary software and closed file formats with complex and highly expensive licensing models. Thus, new opportunities arise for the creation of tools, resources and knowledge that promote the renewal and impetus of the entire sector. Most of the sector’s R&amp;D activities are not only directed to the development of digital tools, but also to develop and provide the methodological bases of standardization, organization, and management of information nece

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Altuntas, C. "THREE-DIMENSIONAL DIGITIZATION OF ENVIRONMENTS AND BUILDINGS FOR SMART CITY APPLICATIONS." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVI-4/W5-2021 (December 23, 2021): 65–71. http://dx.doi.org/10.5194/isprs-archives-xlvi-4-w5-2021-65-2021.

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Abstract. The smart cities that promise a sustainable future cannot be thought of independently from the spatial information infrastructure. It is very important to keep the spatial data infrastructure up-to-date for guidance and information in smart city applications (SCA). Easy and low-cost acquisition is an important factor in updating spatial data. Today, there are many measurement techniques to collecting 3-D spatial data of urban areas and land topography. On the other hand, indoor measurement and 3-D modelling techniques are used in the creation of building information modelling (BIM).

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Jiang, Z., X. Shen, M. H. Ibrahimkhil, K. Barati, and J. Linke. "SCAN-VS-BIM FOR REAL-TIME PROGRESS MONITORING OF BRIDGE CONSTRUCTION PROJECT." ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences X-4/W3-2022 (October 14, 2022): 97–104. http://dx.doi.org/10.5194/isprs-annals-x-4-w3-2022-97-2022.

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Abstract. New transport infrastructure construction can stimulate the growth of economy as well as improving the public citizen welfare. However, with the rising number of mega infrastructure projects, the low project performance, such as project delay and cost escalation, are challenging the traditional Architecture, Engineering, and Construction (AEC) industry. Traditional Construction progress monitoring methods rely on manual data collecting and paperwork reporting which can be labor-intensive, time-consuming and error-prone. Therefore, it is necessary for the involved stakeholders to intr

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Setiami, Rista, and Arris Maulana. "DEVELOPMENT OF E-MODULES IN ENGINEERING DRAWING COURSES WITH THE BIM SYSTEM BUILDING MODELING APPLICATION." Jurnal PenSil 10, no. 1 (2021): 1–7. http://dx.doi.org/10.21009/jpensil.v10i1.17013.

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This research was aimed to develop e-modules on Drawing Engineering Course at Building Engineering Education Study Program so that college students can improve their understanding about BIM and the use of Autodesk Revit Software. The research method used Research and Development (R&D) with ADDIE research model. (1) Analyze, distributed needs analysis questionnaires. (2) Design, carryed out concept design, display, and e-modules material. (3) Development, realized and validated e-modules. (4) Implementation, conducted limited trials and distributed college student response questionnaires. (

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Qi, Mengwen, Chunfeng Wu, Zhouqing Wang, et al. "Transient Receptor Potential Vanilloid 4 Activation-Induced Increase in Glycine-Activated Current in Mouse Hippocampal Pyramidal Neurons." Cellular Physiology and Biochemistry 45, no. 3 (2018): 1084–96. http://dx.doi.org/10.1159/000487350.

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Background/Aims: Glycine plays an important role in regulating hippocampal inhibitory/ excitatory neurotransmission through activating glycine receptors (GlyRs) and acting as a co-agonist of N-methyl-d-aspartate-type glutamate receptors. Activation of transient receptor potential vanilloid 4 (TRPV4) is reported to inhibit hippocampal A-type γ-aminobutyric acid receptor, a ligand-gated chloride ion channel. GlyRs are also ligand-gated chloride ion channels and this paper aimed to explore whether activation of TRPV4 could modulate GlyRs. Methods: Whole-cell patch clamp recording was employed to

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Wu, Zonghu. "Role of microRNA-24 Transfection Mediated by Silica Nanoparticles in Apoptosis of Cardiomyocyte." Science of Advanced Materials 13, no. 3 (2021): 455–62. http://dx.doi.org/10.1166/sam.2021.3952.

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To explore the role of micro RNA-24 (miR-24) mediated by silica nanoparticles (SiNPs) modified by polyethyleneimine (PEI) on apoptosis of cardiomyocyte induced by H2O2, in this study, PEI was selected to modify the surface of SiNPs to obtain F-SiNPs, which were combined with miR-24 through electrostatic adsorption to form F-SiNPs-miR-24. Through characterization, the particle size, charge amount, and microstructure were studied. Then, the CCK-8 method was adopted to detect the toxicity of F-SiNPs on cardiomyocytes, and the cell uptake experiment was performed to analyze the transfection effici

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24

Juliyanti, Novi, Arga Satrio Prabowo, and Putri Dian Dia Conia. "Permainan Tradisional Indonesia Untuk Meningkatkan Wawasan Karir Siswa." EDU SOCIATA ( JURNAL PENDIDIKAN SOSIOLOGI) 7, no. 1 (2024): 143–48. http://dx.doi.org/10.33627/es.v7i1.1937.

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Study This based on problems that occur in teenagers , generally problem That about lack of understanding career . One of way that can be used For solve problem This is give service information in Bim bingan and counseling , with use creative media . Research and development This done aim For developing guidance and counseling media shaped game traditional cranky . Research methods used in study This is research and development (R&D) with draft Thiagarajan 4D model development . There are 4 stages carried out namely Define , Design , Development , Disseminate . Test subjects study This

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Saswat, Mishra, Ch. Sahoo Gopal, Prasad Mishra Siba, Ch. Sethi Kumar, and Siddique Mohammed. "From Squatter Slums to Modelled Dwellings in Anthropocene: Bhubaneswar, India." International Journal of Engineering and Advanced Technology (IJEAT) 9, no. 3 (2020): 2783–93. https://doi.org/10.35940/ijeat.C5935.029320.

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Slums, the poor men paradise, are an informal settlement in Cosmo polis but part to the urban development process. Anthropocene has summoned exodus from rural to urban for food, family education and livelihood. Bhubaneswar, the capital city Odisha was established in 1949 with zero slums till1960’s, now has about 436 slum clusters in 67 wards with 304140 slum dwellers comprising 34.30% of the total population. After declaration as smart city, 2015, inter alia initiatives are taken by federal bodies for the development and resettlement of shantytown dwellers to make it slum less. The Kargi

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Tsuchiya, Yugo, Fiona C. Denison, Richard B. Heath, David Carling, and David Saggerson. "5′-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes." Bioscience Reports 32, no. 2 (2011): 197–209. http://dx.doi.org/10.1042/bsr20110076.

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In adult rat cardiac myocytes adrenaline decreased AMPK (AMP-activated protein kinase) activity with a half-time of approximately 4 min, decreased phosphorylation of AMPK (α-Thr172) and decreased phosphorylation of ACC (acetyl-CoA carboxylase). Inactivation of AMPK by adrenaline was through both α1- and β-ARs (adrenergic receptors), but did not involve cAMP or calcium signalling, was not blocked by the PKC (protein kinase C) inhibitor BIM I (bisindoylmaleimide I), by the ERK (extracellular-signal-regulated kinase) cascade inhibitor U0126 or by PTX (pertussis toxin). Adrenaline caused no measur

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Xu, Wei, Hai-Jia Zhu, Li-Na Zhang, et al. "The BH3-Only Protein Puma Plays An Essential Role in p53-Mediated Apoptosis of Chronic Lymphocytic Leukemia Cells." Blood 118, no. 21 (2011): 4592. http://dx.doi.org/10.1182/blood.v118.21.4592.4592.

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Abstract Abstract 4592 Objective Chronic lymphocytic leukemia (CLL) is a heterogeneous malignant hematologic disease; the response to chemotherapy partly determines the prognosis of patients. Fludarabine, which is frequently used in the treatment of CLL, induces CLL cell apoptosis by activating p53 and then down stream BH3-only family members, consequent to the induction of DNA damage. To identify which is the key factor in this apoptosis pathway, we incubated CLL cells with an active metabolite of fludarabine, 9-β-D-arabinosyl-2-fluoroadenine (F-ara-A), in vitro and then analyzed the role of

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Salmanidis, Marika, Gabi Brumatti, Anissa M. Jabbour, et al. "Regulated Hox Gene Expression Reveals a Novel Role for Hox Genes in Myeloid Cell Proliferation and Survival." Blood 112, no. 11 (2008): 5323. http://dx.doi.org/10.1182/blood.v112.11.5323.5323.

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Abstract The Hox family of homeodomain transcription factors are essential for the regulation of hematopoiesis and deregulated expression of some Hox gene is associated with the development of myeloproliferative disorders and leukaemia. In mammals, 39 Hox genes are organized into four clusters (A, B, C or D). The expression of these genes is tightly regulated at particular differentiation points in haematopoiesis. Importantly, the over-expression of Hox genes, HoxB4, HoxA9 and HoxA10 is frequent in acute myeloid leukaemia, and may arise as a result of MLL rearrangements or from translocations

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Khaw, Seong Lin, David C. Huang, Simon He, et al. "Biomarkers and In Vivo Responses to the BH3 Mimetic, ABT-263, in Patients (pts) with Chronic Lymphocytic Leukemia (CLL)." Blood 114, no. 22 (2009): 2374. http://dx.doi.org/10.1182/blood.v114.22.2374.2374.

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Abstract Abstract 2374 Poster Board II-351 ABT-263 is a first-in-class BH3 mimetic inhibitor of 3 pro-survival members of the BCL2 protein family (BCL2, BCLXL, BCLW). Consistent with potent activity against BCL2-overexpressing cell lines and primary CLL cells in vitro, and BCL2-overexpressing lymphoid murine tumors in vivo, ABT-263 demonstrated significant antitumor activity in pts with relapsed, refractory CLL and small lymphocytic lymphoma (SLL) in 2 phase 1/2a studies. To date, 42 pts (35 evaluable) with CLL/SLL have been treated with ABT-263 (40-440 mg/d). 51% (18/35) with a baseline lymph

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Han, Lina, Qi Zhang, Ce Shi, et al. "Targeting MAPK Signaling Pathway with Cobimetinib (GDC-0973) Enhances Anti-Leukemia Efficacy of Venetoclax (ABT-199/GDC-0199) in Acute Myeloid Leukemia Models." Blood 128, no. 22 (2016): 97. http://dx.doi.org/10.1182/blood.v128.22.97.97.

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Abstract Despite advances in understanding of the biology of acute myeloid leukemia (AML), cure remains elusive for the majority of patients. Pro-survival molecules of BCL-2 family play critical roles in leukemia transformation and chemoresistance. The anti-leukemia potency of selective BCL-2 inhibitor venetoclax (ABT-199/GDC-0199) has been demonstrated in AML models (Pan et al. Cancer Discovery 2014). However, venetoclax is often associated with resistance due to its poor inhibition of MCL-1. RAF/MEK/ERK (MAPK) pathway is commonly activated in AML, and can stabilize anti-apoptotic MCL-1 and i

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Konopleva, Marina, Juliana M. Benito, Karine G. Harutyunyan, et al. "Acute Lymphoblastic Leukemia Is a Bcl-2 Dependent Disease: Proteomic Profiling and Pre-Clinical Efficacy Of a Selective Bcl-2 Antagonist ABT-199." Blood 122, no. 21 (2013): 3919. http://dx.doi.org/10.1182/blood.v122.21.3919.3919.

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Abstract The expression of Bcl-2 family proteins is perturbed in multiple types of cancers, including leukemias, and is associated with disease progression and resistance to chemotherapy. ABT-199 (GDC-0199) is a new BH3 mimetic that was developed to specifically target Bcl-2 while sparing Bcl-XL, hence avoiding thrombocytopenia intrinsic to 1st generation BH3 mimetics like ABT-737 (Souers et al., Nat Med, 2013). In this study, we report proteomic profiling of Bcl-2 family members in a large series of ALL patients (pts) and pre-clinical activity of ABT-199. Expression of 20 pro- and anti-apopto

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Komatsu, Y., S. Nakajima, and K. Toyama. "Induction of long-term potentiation without participation of N-methyl-D-aspartate receptors in kitten visual cortex." Journal of Neurophysiology 65, no. 1 (1991): 20–32. http://dx.doi.org/10.1152/jn.1991.65.1.20.

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1. Intracellular recording was made from layer II-III cells in slice preparations of kitten (30-40 days old) visual cortex. Low-frequency (0.1 Hz) stimulation of white matter (WM) usually evoked an excitatory postsynaptic potential (EPSP) followed by an inhibitory postsynaptic potential (IPSP). The postsynaptic potentials (PSPs) showed strong dependence on stimulus frequency. Early component of EPSP and IPSP evoked by weak stimulation both decreased monotonically at frequencies greater than 0.5-1 Hz. Strong stimulation similarly depressed the early EPSP at higher frequencies (greater than 2 Hz

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Arun Kumar Epuri. "The Evolution and Future of Virtual Reality in Geographic Information Systems." International Journal of Scientific Research in Computer Science, Engineering and Information Technology 10, no. 5 (2024): 544–51. http://dx.doi.org/10.32628/cseit241051043.

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MarketsandMarkets, "Geographic Information System (GIS) Market," 2020. [Online]. Available: https://www.marketsandmarkets.com/Market-Reports/geographic-information-system-market-55818039.html Grand View Research, "Augmented Reality & Virtual Reality Market Size, Share & Trends Analysis Report By Technology (Augmented Reality, Virtual Reality), By Component, By Device Type, By Application, By Region, And Segment Forecasts, 2021 - 2028," Feb. 2021. [Online]. Available: https://www.gmiresearch.com/report/augmented-reality-and-virtual-reality-market/ P. Cozzi and K. Ring, 3D Engine Design

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Jenkins, Laura J., Ian Y. Luk, Walter D. Fairlie, et al. "Abstract B014: Genotype-tailored ERK/MAPK pathway and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death." Cancer Research 82, no. 23_Supplement_1 (2022): B014. http://dx.doi.org/10.1158/1538-7445.crc22-b014.

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Abstract The EGFR/RAS/MEK/ERK signaling pathway (ERK/MAPK) is hyper-activated in most colorectal cancers (CRCs). A current limitation of inhibitors of this pathway is that they primarily induce cytostatic effects in CRC cells. Nevertheless, these drugs do induce expression of pro-apoptotic factors, suggesting they may prime CRC cells to undergo apoptosis. As histone deacetylase inhibitors (HDACi) induce expression of multiple pro-apoptotic proteins, we examined whether they could synergize with ERK/MAPK inhibitors to trigger CRC cell apoptosis. Combined MEK/ERK and HDAC inhibition synergistica

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Pohlen, U., H. Ebhardt, M. Kruschewski, and H. J. Buhr. "D�nndarminvagination beim Erwachsenen." Der Chirurg 74, no. 12 (2003): 1117. http://dx.doi.org/10.1007/s00104-003-0778-4.

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Povoroznyuk, V. V., N. V. Dedukh, M. A. Bystrytska, and V. S. Shapovalov. "Bone remodeling stages under physiological conditions and glucocorticoid in excess: Focus on cellular and molecular mechanisms." Regulatory Mechanisms in Biosystems 12, no. 2 (2021): 212–27. http://dx.doi.org/10.15421/022130.

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This review provides a rationale for the cellular and molecular mechanisms of bone remodeling stages under physiological conditions and glucocorticoids (GCs) in excess. Remodeling is a synchronous process involving bone resorption and formation, proceeding through stages of: (1) resting bone, (2) activation, (3) bone resorption, (4) reversal, (5) formation, (6) termination. Bone remodeling is strictly controlled by local and systemic regulatory signaling molecules. This review presents current data on the interaction of osteoclasts, osteoblasts and osteocytes in bone remodeling and defines the

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Kaufman, Jonathan L., Cristina Gasparetto, Fredrik H. Schjesvold, et al. "Phase I/II Study Evaluating the Safety and Efficacy of Venetoclax in Combination with Dexamethasone As Targeted Therapy for Patients with t(11;14) Relapsed/Refractory Multiple Myeloma." Blood 134, Supplement_1 (2019): 926. http://dx.doi.org/10.1182/blood-2019-125871.

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Background Venetoclax (Ven) is a selective, small molecule inhibitor of anti-apoptosis protein Bcl-2 that has antitumoral activity against multiple myeloma (MM), notably those with translocation t(11;14). Dexamethasone (d) has shown to enhance the expression of BCL-2 and pro-apoptotic protein Bim, shifting its binding towards Bcl-2 and sensitizing MM cells to Ven. This Phase 1/2 open-label trial is evaluating the safety and efficacy of the combination of Ven+d as a therapeutic approach to improve clinical outcomes in patients with t(11;14) Relapsed/Refractory (R/R) MM. Methods This ongoing stu

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Du, Jinwei, Shigemi Matsuyama, and Yu-Chung Yang. "CITED2 Facilitates Apoptosis Induced By Histone Deacetylase Inhibitor SAHA In Human Pediatric Pre-B Acute Lymphoblastic Leukemia Cells." Blood 122, no. 21 (2013): 2913. http://dx.doi.org/10.1182/blood.v122.21.2913.2913.

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Abstract Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood, representing 31% of all tumors, and about 85% of children with ALL have B-cell ALL. Although the survival rate is approaching 90%, ALL remains the main cause of death from disease in children and young adults. The activity of histone deacetylases (HDAC) in childhood ALL is increased compared with that in normal peripheral blood mononuclear cells or bone marrow cells. Treatment of mice engrafted with T or B-ALL cells with HDAC inhibitor (HDACi) increases the acetylation of Histone 3 and Histone 4 and prolong

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Kampa, Leonie Elisabeth, Anton Bleisch, Philipp Peslalz, Marcus Matthias Schittenhelm, Bernd Plietker, and Kerstin Maria Kampa-Schittenhelm. "A New Class of Synthetic Type-B Polycyclic Polyprenylated Acylphloroglucinols (PPAP-B) Overcomes Venetoclax-Resistance in Acute Myeloid Leukemia (AML)." Blood 142, Supplement 1 (2023): 4157. http://dx.doi.org/10.1182/blood-2023-189692.

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Venetoclax (VEN) resistance in AML therapy is a field of unmet need. VEN selectively binds in the BH3-binding groove of BCL-2 to release BIM leading to pore-forming BAX/BAK dimerization to finally release cytochrome C, as the “step of no return” in induction of programmed cell death. Compensatory overexpression of other BCL-2 family members such as MCL-1 and BCL-XL is a well described resistance mechanism to restore the ability to sequester BIM and therefore compensate for BCL-2 inhibition. Type-B PPAP are a novel class of neoplastic therapeutics. A new synthetic toolbox for the coupling of a

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Choi, So Young, Tong Un Chae, Jihoon Shin, Jung Ae Im, and Sang Yup Lee. "Biosynthesis and characterization of poly( d ‐lactate‐ co ‐glycolate‐ co ‐4‐hydroxybutyrate)." Biotechnology and Bioengineering 117, no. 7 (2020): 2187–97. http://dx.doi.org/10.1002/bit.27354.

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Pletnev, V. Z., V. T. Ivanov, D. A. Langs, P. Strong, and W. L. Duax. "Crystal and molecular structure of the depsipeptide ionophore Hexadecaisoleucinomycin, cyclo-[-(D-Ile-L-Lac-L-Ile-D-Hyi)4-] (C80H136N8O24)." Biopolymers 32, no. 7 (1992): 819–27. http://dx.doi.org/10.1002/bip.360320710.

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Laikha, Ulfatul, Bim Tampubolon, and A. Subrata. "Pengaruh Lama Peram Proses Fermentasi Kulit Kacang Tanah Amoniasi dengan Aspergillus niger terhadap Produksi VFA dan NH3 secara In vitro." Jurnal Ilmu Nutrisi dan Teknologi Pakan 17, no. 3 (2019): 69–72. http://dx.doi.org/10.29244/jintp.17.3.69-72.

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The aim of this research was to examine the effect of fermentation time by Aspergillus niger on peanut shells ammoniated on VFA and NH3 production. The research was allocated in a completely randomized design with 4 treatments and 4 replications. The treatments were fermentation process of 0 days (T0), 5 days (T1), 10 days (T2) and 15 days (T3). The results showed that fermentation process with A. niger on the ammoniated peanut shells increased (p<0.05) the VFA and NH3 production. In an incubation time of 15 days, the highest VFA and NH3 production waas obtained. The average production of V

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Holick, Michael F. "Vitamin D." Clinical Reviews in Bone and Mineral Metabolism 1, no. 3-4 (2002): 181–208. http://dx.doi.org/10.1385/bmm:1:3-4:181.

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Addepalli, Sardhak, Venkat Mouneesh Reddy Beesu, C. R. Manjunath, and Shetty Sahana. "Survey Paper on 3 D Bio Printing for Hard Tissue." International Journal of Trend in Scientific Research and Development 2, no. 4 (2018): 648–55. https://doi.org/10.31142/ijtsrd13051.

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Three dimensional bioprinting is basically for creating or formation of the natural developing which includes allocating cells into the biocompatible stage by applying a liberal layer by layer for dealing with the tissue like three dimensional 3D structures. As we know each muscle in the body is made out from various types of cells, various advances for the printing of these headsets will differ in their size to maintain assurance on steadiness and reasonability of headsets which exists within the Assembling process. There is a huge exploration going on bioprinting innovation and discovering i

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Di Blasio, Benedetto, Ettore Benedetti, Vincenzo Pavone, Carlo Pedone, Ottavia Spiniello, and Gian Paolo Lorenzi. "Regularly alternatingL,D-peptides. I. The double-stranded left-handed antiparallel ?-helix in the structure of Boc-(L-Val-D-Val)4-OMe." Biopolymers 28, no. 1 (1989): 193–201. http://dx.doi.org/10.1002/bip.360280121.

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Di Blasio, Benedetto, Ettore Benedetti, Vincenzo Pavone, Carlo Pedone, Cristoph Gerber, and Gian Paolo Lorenzi. "Regularly alternatingL,D-peptides. II. The double-stranded right-handed antiparallel ?-helix in the structure oft-Boc-(L-Phe-D-Phe)4-OMe." Biopolymers 28, no. 1 (1989): 203–14. http://dx.doi.org/10.1002/bip.360280122.

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ter Elst, Arja, Steven M. Kornblau, Frank jg Scherpen, et al. "Epidermal Growth Factor Receptor Expression and Activity In Acute Myeloid Leukemia." Blood 116, no. 21 (2010): 3144. http://dx.doi.org/10.1182/blood.v116.21.3144.3144.

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Abstract Abstract 3144 It was previously described that Epidermal Growth Factor Receptor (EGFR) inhibitors can induce a clinical response in AML patients (Boehrer et al., 2008; Chan and Pilichowska, 2007; Pitini et al., 2008). In contrast, it was reported that EGFR is not expressed in AML cells both at protein and mRNA level and that the phenotypic effects of the EGFR inhibitors are off-target effects on the spleen tyrosine kinase (SYK) (Lindhagen et al., 2008; Stegmaier et al., 2005; Hahn et al., 2009). We have, however, detected EGFR mRNA expression in gene expression array data of 534 publi

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Arakawa, H., T. Ikegami, M. Maeda та A. Tsuji. "Chemiluminescent enzyme immunoassay for alpha-fetoprotein using β-D-galactosidase as label and 5-bromo-4-chloro-3-indolyl-β-D-galactopyranoside as substrate". Journal of Bioluminescence and Chemiluminescence 8, № 3 (1993): 135–39. http://dx.doi.org/10.1002/bio.1170080302.

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Kricka, L. J. "Light emission by plants and bacteria. Edited by Govindjee, J. Amesz, and D. D. Fork Academic Press, Orlando, 1986. (ISBN 0 12 294310 4) $85.00." Journal of Bioluminescence and Chemiluminescence 2, no. 2 (1988): 112. http://dx.doi.org/10.1002/bio.1170020209.

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Chen, Evan C., Yiwen Liu, Hayden L. Bell, et al. "Dual Bclxl and BCL2 Inhibition with Navitoclax (NAV), Venetoclax (VEN), and Decitabine (DEC) for Advanced Myeloid Neoplasms (MN): Safety and Biological Activity in a Phase 1 Study." Blood 144, Supplement 1 (2024): 4580. https://doi.org/10.1182/blood-2024-198284.

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Introduction: The combination of a DNA methyltransferase inhibitor (DNMTi) and the BCL2 inhibitor venetoclax (VEN) is effective for newly-diagnosed acute myeloid leukemia (AML). However, response rates of VEN/DNMTi are lower for other advanced myeloid neoplasms (MN). One resistance mechanism to VEN is increased cell dependence on the alternative anti-apoptotic protein BCLxL. We hypothesized that addition of the BCLxL/BCL2 inhibitor navitoclax (NAV) to VEN would increase apoptotic priming in advanced MNs and facilitate lower NAV dosing to reduce its platelet (PLT)-associated toxicity. We report

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