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Journal articles on the topic 'BIN2'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Hao, Yuhan, Haijiao Wang, Shenglong Qiao, Linna Leng, and Xuelu Wang. "Histone deacetylase HDA6 enhances brassinosteroid signaling by inhibiting the BIN2 kinase." Proceedings of the National Academy of Sciences 113, no. 37 (August 25, 2016): 10418–23. http://dx.doi.org/10.1073/pnas.1521363113.

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Glycogen synthase kinase 3 (GSK3)-like kinases play important roles in brassinosteroid (BR), abscisic acid, and auxin signaling to regulate many aspects of plant development and stress responses. The Arabidopsis thaliana GSK3-like kinase BR-INSENSITIVE 2 (BIN2) acts as a key negative regulator in the BR signaling pathway, but the mechanisms regulating BIN2 function remain unclear. Here we report that the histone deacetylase HDA6 can interact with and deacetylate BIN2 to repress its kinase activity. The hda6 mutant showed a BR-repressed phenotype in the dark and was less sensitive to BR biosynthesis inhibitors. Genetic analysis indicated that HDA6 regulates BR signaling through BIN2. Furthermore, we identified K189 of BIN2 as an acetylated site, which can be deacetylated by HDA6 to influence BIN2 activity. Glucose can affect the acetylation level of BIN2 in plants, indicating a connection to cellular energy status. These findings provide significant insights into the regulation of GSK3-like kinases in plant growth and development.

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2

Ling, Jun-Jie, Jian Li, Danmeng Zhu, and Xing Wang Deng. "Noncanonical role of Arabidopsis COP1/SPA complex in repressing BIN2-mediated PIF3 phosphorylation and degradation in darkness." Proceedings of the National Academy of Sciences 114, no. 13 (March 14, 2017): 3539–44. http://dx.doi.org/10.1073/pnas.1700850114.

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The E3 ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) has been known to mediate key signaling factors for degradation via the ubiquitin/26S proteasome pathway in both plants and animals. Here, we report a noncanonical function of Arabidopsis COP1, the central repressor of photomorphogenesis, in the form of a COP1/ SUPPRESSOR of phyA-105 (SPA) complex. We show that the COP1/SPA complex associates with and stabilizes PHYTOCHROME INTERACTING FACTOR 3 (PIF3) to repress photomorphogenesis in the dark. We identify the GSK3-like kinase BRASSINOSTEROID-INSENSITIVE 2 (BIN2) as a kinase of PIF3, which induces PIF3 degradation via 26S proteasome during skotomorphogenesis. Mutations on two typical BIN2 phosphorylation motifs of PIF3 lead to a strong stabilization of the protein in the dark. We further show that the COP1/SPA complex promotes PIF3 stability by repressing BIN2 activity. Intriguingly, without affecting BIN2 expression, the COP1/SPA complex modulates BIN2 activity through interfering with BIN2–PIF3 interaction, thereby inhibiting BIN2-mediated PIF3 phosphorylation and degradation. Taken together, our results suggest another paradigm for COP1/SPA complex action in the precise control of skotomorphogenesis.

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3

Sánchez-Rodríguez, Clara, KassaDee Ketelaar, Rene Schneider, Jose A. Villalobos, Chris R. Somerville, Staffan Persson, and Ian S. Wallace. "BRASSINOSTEROID INSENSITIVE2 negatively regulates cellulose synthesis in Arabidopsis by phosphorylating cellulose synthase 1." Proceedings of the National Academy of Sciences 114, no. 13 (March 13, 2017): 3533–38. http://dx.doi.org/10.1073/pnas.1615005114.

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The deposition of cellulose is a defining aspect of plant growth and development, but regulation of this process is poorly understood. Here, we demonstrate that the protein kinase BRASSINOSTEROID INSENSITIVE2 (BIN2), a key negative regulator of brassinosteroid (BR) signaling, can phosphorylate Arabidopsis cellulose synthase A1 (CESA1), a subunit of the primary cell wall cellulose synthase complex, and thereby negatively regulate cellulose biosynthesis. Accordingly, point mutations of the BIN2-mediated CESA1 phosphorylation site abolished BIN2-dependent regulation of cellulose synthase activity. Hence, we have uncovered a mechanism for how BR signaling can modulate cellulose synthesis in plants.

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4

Li, Jianming, Kyoung Hee Nam, Dionne Vafeados, and Joanne Chory. "BIN2, a New Brassinosteroid-Insensitive Locus in Arabidopsis." Plant Physiology 127, no. 1 (September 1, 2001): 14–22. http://dx.doi.org/10.1104/pp.127.1.14.

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5

Sun, Yan, and Randy D. Allen. "Functional analysis of the BIN2 genes of cotton." Molecular Genetics and Genomics 274, no. 1 (June 23, 2005): 51–59. http://dx.doi.org/10.1007/s00438-005-1122-0.

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6

Naranjo, Isaac Daimiel, Alexis Reymbaut, Patrik Brynolfsson, Roberto Lo Gullo, Karin Bryskhe, Daniel Topgaard, Dilip D. Giri, Jeffrey S. Reiner, Sunitha B. Thakur, and Katja Pinker-Domenig. "Multidimensional Diffusion Magnetic Resonance Imaging for Characterization of Tissue Microstructure in Breast Cancer Patients: A Prospective Pilot Study." Cancers 13, no. 7 (March 31, 2021): 1606. http://dx.doi.org/10.3390/cancers13071606.

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Diffusion-weighted imaging is a non-invasive functional imaging modality for breast tumor characterization through apparent diffusion coefficients. Yet, it has so far been unable to intuitively inform on tissue microstructure. In this IRB-approved prospective study, we applied novel multidimensional diffusion (MDD) encoding across 16 patients with suspected breast cancer to evaluate its potential for tissue characterization in the clinical setting. Data acquired via custom MDD sequences was processed using an algorithm estimating non-parametric diffusion tensor distributions. The statistical descriptors of these distributions allow us to quantify tissue composition in terms of metrics informing on cell densities, shapes, and orientations. Additionally, signal fractions from specific cell types, such as elongated cells (bin1), isotropic cells (bin2), and free water (bin3), were teased apart. Histogram analysis in cancers and healthy breast tissue showed that cancers exhibited lower mean values of “size” (1.43 ± 0.54 × 10−3 mm2/s) and higher mean values of “shape” (0.47 ± 0.15) corresponding to bin1, while FGT (fibroglandular breast tissue) presented higher mean values of “size” (2.33 ± 0.22 × 10−3 mm2/s) and lower mean values of “shape” (0.27 ± 0.11) corresponding to bin3 (p < 0.001). Invasive carcinomas showed significant differences in mean signal fractions from bin1 (0.64 ± 0.13 vs. 0.4 ± 0.25) and bin3 (0.18 ± 0.08 vs. 0.42 ± 0.21) compared to ductal carcinomas in situ (DCIS) and invasive carcinomas with associated DCIS (p = 0.03). MDD enabled qualitative and quantitative evaluation of the composition of breast cancers and healthy glands.

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7

Wang, Haijiao, Song Song, Huaqiang Cheng, and Yan-Wen Tan. "State-of-the-Art Technologies for Understanding Brassinosteroid Signaling Networks." International Journal of Molecular Sciences 21, no. 21 (October 31, 2020): 8179. http://dx.doi.org/10.3390/ijms21218179.

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Brassinosteroids, the steroid hormones of plants, control physiological and developmental processes through its signaling pathway. The major brassinosteroid signaling network components, from the receptor to transcription factors, have been identified in the past two decades. The development of biotechnologies has driven the identification of novel brassinosteroid signaling components, even revealing several crosstalks between brassinosteroid and other plant signaling pathways. Herein, we would like to summarize the identification and improvement of several representative brassinosteroid signaling components through the development of new technologies, including brassinosteroid-insensitive 1 (BRI1), BRI1-associated kinase 1 (BAK1), BR-insensitive 2 (BIN2), BRI1 kinase inhibitor 1 (BKI1), BRI1-suppressor 1 (BSU1), BR signaling kinases (BSKs), BRI1 ethyl methanesulfonate suppressor 1 (BES1), and brassinazole resistant 1 (BZR1). Furthermore, improvement of BR signaling knowledge, such as the function of BKI1, BES1 and its homologous through clustered regularly interspaced short palindromic repeats (CRISPR), the regulation of BIN2 through single-molecule methods, and the new in vivo interactors of BIN2 identified by proximity labeling are described. Among these technologies, recent advanced methods proximity labeling and single-molecule methods will be reviewed in detail to provide insights to brassinosteroid and other phytohormone signaling pathway studies.

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8

Zhao, J. "Two Putative BIN2 Substrates Are Nuclear Components of Brassinosteroid Signaling." PLANT PHYSIOLOGY 130, no. 3 (October 15, 2002): 1221–29. http://dx.doi.org/10.1104/pp.102.010918.

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9

Volz, Julia, Charly Kusch, Sarah Beck, Michael Popp, Timo Vögtle, Mara Meub, Inga Scheller, et al. "BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation." Journal of Clinical Investigation 130, no. 11 (October 12, 2020): 6064–79. http://dx.doi.org/10.1172/jci136457.

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10

Zhang, Zhenzhen, Ying Sun, Xue Jiang, Wenfei Wang, and Zhi-Yong Wang. "Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1." PLOS Genetics 17, no. 5 (May 14, 2021): e1009540. http://dx.doi.org/10.1371/journal.pgen.1009540.

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Sugar, light, and hormones are major signals regulating plant growth and development, however, the interactions among these signals are not fully understood at the molecular level. Recent studies showed that sugar promotes hypocotyl elongation by activating the brassinosteroid (BR) signaling pathway after shifting Arabidopsis seedlings from light to extended darkness. Here, we show that sugar inhibits BR signaling in Arabidopsis seedlings grown under light. BR induction of hypocotyl elongation in seedlings grown under light is inhibited by increasing concentration of sucrose. The sugar inhibition of BR response is correlated with decreased effect of BR on the dephosphorylation of BZR1, the master transcription factor of the BR signaling pathway. This sugar effect is independent of the sugar sensors Hexokinase 1 (HXK1) and Target of Rapamycin (TOR), but requires the GSK3-like kinase Brassinosteroid-Insensitive 2 (BIN2), which is stabilized by sugar. Our study uncovers an inhibitory effect of sugar on BR signaling in plants grown under light, in contrast to its promotive effect in the dark. Such light-dependent sugar-BR crosstalk apparently contributes to optimal growth responses to photosynthate availability according to light-dark conditions.

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11

Bulgakov, Victor P., and Tatiana V. Avramenko. "Linking Brassinosteroid and ABA Signaling in the Context of Stress Acclimation." International Journal of Molecular Sciences 21, no. 14 (July 20, 2020): 5108. http://dx.doi.org/10.3390/ijms21145108.

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The important regulatory role of brassinosteroids (BRs) in the mechanisms of tolerance to multiple stresses is well known. Growing data indicate that the phenomenon of BR-mediated drought stress tolerance can be explained by the generation of stress memory (the process known as ‘priming’ or ‘acclimation’). In this review, we summarize the data on BR and abscisic acid (ABA) signaling to show the interconnection between the pathways in the stress memory acquisition. Starting from brassinosteroid receptors brassinosteroid insensitive 1 (BRI1) and receptor-like protein kinase BRI1-like 3 (BRL3) and propagating through BR-signaling kinases 1 and 3 (BSK1/3) → BRI1 suppressor 1 (BSU1) ―‖ brassinosteroid insensitive 2 (BIN2) pathway, BR and ABA signaling are linked through BIN2 kinase. Bioinformatics data suggest possible modules by which BRs can affect the memory to drought or cold stresses. These are the BIN2 → SNF1-related protein kinases (SnRK2s) → abscisic acid responsive elements-binding factor 2 (ABF2) module; BRI1-EMS-supressor 1 (BES1) or brassinazole-resistant 1 protein (BZR1)–TOPLESS (TPL)–histone deacetylase 19 (HDA19) repressor complexes, and the BZR1/BES1 → flowering locus C (FLC)/flowering time control protein FCA (FCA) pathway. Acclimation processes can be also regulated by BR signaling associated with stress reactions caused by an accumulation of misfolded proteins in the endoplasmic reticulum.

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12

Liu, Xiaolei, Qin Yang, Yuan Wang, Linhai Wang, Ying Fu, and Xuelu Wang. "Brassinosteroids regulate pavement cell growth by mediating BIN2-induced microtubule stabilization." Journal of Experimental Botany 69, no. 5 (January 10, 2018): 1037–49. http://dx.doi.org/10.1093/jxb/erx467.

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13

Ge, Kai, and George C. Prendergast. "Bin2, a Functionally Nonredundant Member of the BAR Adaptor Gene Family." Genomics 67, no. 2 (July 2000): 210–20. http://dx.doi.org/10.1006/geno.2000.6216.

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14

Anne, Pauline, Marianne Azzopardi, Lionel Gissot, Sébastien Beaubiat, Kian Hématy, and Jean-Christophe Palauqui. "OCTOPUS Negatively Regulates BIN2 to Control Phloem Differentiation in Arabidopsis thaliana." Current Biology 25, no. 19 (October 2015): 2584–90. http://dx.doi.org/10.1016/j.cub.2015.08.033.

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15

Lv, Minghui, and Jia Li. "Molecular Mechanisms of Brassinosteroid-Mediated Responses to Changing Environments in Arabidopsis." International Journal of Molecular Sciences 21, no. 8 (April 15, 2020): 2737. http://dx.doi.org/10.3390/ijms21082737.

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Plant adaptations to changing environments rely on integrating external stimuli into internal responses. Brassinosteroids (BRs), a group of growth-promoting phytohormones, have been reported to act as signal molecules mediating these processes. BRs are perceived by cell surface receptor complex including receptor BRI1 and coreceptor BAK1, which subsequently triggers a signaling cascade that leads to inhibition of BIN2 and activation of BES1/BZR1 transcription factors. BES1/BZR1 can directly regulate the expression of thousands of downstream responsive genes. Recent studies in the model plant Arabidopsis demonstrated that BR biosynthesis and signal transduction, especially the regulatory components BIN2 and BES1/BZR1, are finely tuned by various environmental cues. Here, we summarize these research updates and give a comprehensive review of how BR biosynthesis and signaling are modulated by changing environments and how these changes regulate plant adaptive growth or stress tolerance.

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16

Mao, Juan, and Jianming Li. "Regulation of Three Key Kinases of Brassinosteroid Signaling Pathway." International Journal of Molecular Sciences 21, no. 12 (June 18, 2020): 4340. http://dx.doi.org/10.3390/ijms21124340.

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Brassinosteroids (BRs) are important plant growth hormones that regulate a wide range of plant growth and developmental processes. The BR signals are perceived by two cell surface-localized receptor kinases, Brassinosteroid-Insensitive1 (BRI1) and BRI1-Associated receptor Kinase (BAK1), and reach the nucleus through two master transcription factors, bri1-EMS suppressor1 (BES1) and Brassinazole-resistant1 (BZR1). The intracellular transmission of the BR signals from BRI1/BAK1 to BES1/BZR1 is inhibited by a constitutively active kinase Brassinosteroid-Insensitive2 (BIN2) that phosphorylates and negatively regulates BES1/BZR1. Since their initial discoveries, further studies have revealed a plethora of biochemical and cellular mechanisms that regulate their protein abundance, subcellular localizations, and signaling activities. In this review, we provide a critical analysis of the current literature concerning activation, inactivation, and other regulatory mechanisms of three key kinases of the BR signaling cascade, BRI1, BAK1, and BIN2, and discuss some unresolved controversies and outstanding questions that require further investigation.

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17

Li, Taotao, Wei Lei, Ruiyuan He, Xiaoya Tang, Jifu Han, Lijuan Zou, Yanhai Yin, Honghui Lin, and Dawei Zhang. "Brassinosteroids regulate root meristem development by mediating BIN2-UPB1 module in Arabidopsis." PLOS Genetics 16, no. 7 (July 1, 2020): e1008883. http://dx.doi.org/10.1371/journal.pgen.1008883.

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18

Zeng, Haitao, Qi Tang, and Xuejun Hua. "Arabidopsis Brassinosteroid Mutants det2-1 and bin2-1 Display Altered Salt Tolerance." Journal of Plant Growth Regulation 29, no. 1 (July 22, 2009): 44–52. http://dx.doi.org/10.1007/s00344-009-9111-x.

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19

Yan, Zhenyan, Jun Zhao, Peng Peng, Ray K. Chihara, and Jianming Li. "BIN2 Functions Redundantly with Other Arabidopsis GSK3-Like Kinases to Regulate Brassinosteroid Signaling." Plant Physiology 150, no. 2 (April 24, 2009): 710–21. http://dx.doi.org/10.1104/pp.109.138099.

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20

Jeong, Yu Jeong. "Putative E3 ligases as candidates controlling BRASSINOSTEROID INSENSITIVE 2 (BIN2) kinase in Arabidopsis." Plant Biotechnology Reports 14, no. 6 (November 19, 2020): 703–12. http://dx.doi.org/10.1007/s11816-020-00646-1.

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21

Maharjan, Puna Maya, Burkhard Schulz, and Sunghwa Choe. "BIN2/DWF12 Antagonistically Transduces Brassinosteroid and Auxin Signals in the Roots of Arabidopsis." Journal of Plant Biology 54, no. 2 (March 2, 2011): 126–34. http://dx.doi.org/10.1007/s12374-010-9138-3.

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22

Zhang, Dawei, Huaxin Ye, Hongqing Guo, Abbagail Johnson, Honghui Lin, and Yanhai Yin. "Transcription factors involved in brassinosteroid repressed gene expression and their regulation by BIN2 kinase." Plant Signaling & Behavior 9, no. 3 (February 13, 2014): e27849. http://dx.doi.org/10.4161/psb.27849.

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23

Lee, Kyounghee, and Pil Joon Seo. "High-temperature promotion of callus formation requires the BIN2-ARF-LBD axis in Arabidopsis." Planta 246, no. 4 (August 1, 2017): 797–802. http://dx.doi.org/10.1007/s00425-017-2747-z.

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24

Sánchez-Barrena, María José, Yvonne Vallis, Menna R. Clatworthy, Gary J. Doherty, Dmitry B. Veprintsev, Philip R. Evans, and Harvey T. McMahon. "Bin2 Is a Membrane Sculpting N-BAR Protein That Influences Leucocyte Podosomes, Motility and Phagocytosis." PLoS ONE 7, no. 12 (December 20, 2012): e52401. http://dx.doi.org/10.1371/journal.pone.0052401.

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25

Nagy, Gabriella, Peng Lu, and Amy V. Walker. "An investigation of secondary ion yield enhancement using Bin2+ (n=1, 3, 5) primary ions." Journal of the American Society for Mass Spectrometry 19, no. 1 (January 2008): 33–45. http://dx.doi.org/10.1016/j.jasms.2007.10.016.

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26

Wang, Haijiao, Jie Tang, Jing Liu, Jin Hu, Jingjing Liu, Yuxiao Chen, Zhenying Cai, and Xuelu Wang. "Abscisic Acid Signaling Inhibits Brassinosteroid Signaling through Dampening the Dephosphorylation of BIN2 by ABI1 and ABI2." Molecular Plant 11, no. 2 (February 2018): 315–25. http://dx.doi.org/10.1016/j.molp.2017.12.013.

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27

Zhang, Dawei, Huaxun Ye, Hongqing Guo, Abbagail Johnson, Meishan Zhang, Honghui Lin, and Yanhai Yin. "Transcription factor HAT1 is phosphorylated by BIN2 kinase and mediates brassinosteroid repressed gene expression in Arabidopsis." Plant Journal 77, no. 1 (December 3, 2013): 59–70. http://dx.doi.org/10.1111/tpj.12368.

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28

Ryu, Hojin, Kangmin Kim, Hyunwoo Cho, and Ildoo Hwang. "Predominant actions of cytosolic BSU1 and nuclear BIN2 regulate subcellular localization of BES1 in brassinosteroid signaling." Molecules and Cells 29, no. 3 (January 14, 2010): 291–96. http://dx.doi.org/10.1007/s10059-010-0034-y.

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29

Cho, Hyunwoo, Hojin Ryu, Sangchul Rho, Kristine Hill, Stephanie Smith, Dominique Audenaert, Joonghyuk Park, et al. "A secreted peptide acts on BIN2-mediated phosphorylation of ARFs to potentiate auxin response during lateral root development." Nature Cell Biology 16, no. 1 (December 22, 2013): 66–76. http://dx.doi.org/10.1038/ncb2893.

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30

Kim, Tae-Wuk, Shenheng Guan, Alma L. Burlingame, and Zhi-Yong Wang. "The CDG1 Kinase Mediates Brassinosteroid Signal Transduction from BRI1 Receptor Kinase to BSU1 Phosphatase and GSK3-like Kinase BIN2." Molecular Cell 43, no. 4 (August 2011): 561–71. http://dx.doi.org/10.1016/j.molcel.2011.05.037.

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31

He, J. X., J. M. Gendron, Y. Yang, J. Li, and Z. Y. Wang. "The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis." Proceedings of the National Academy of Sciences 99, no. 15 (July 11, 2002): 10185–90. http://dx.doi.org/10.1073/pnas.152342599.

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32

Bu, Shuo-Lei, Chao Liu, Ning Liu, Ji-Long Zhao, Lian-Feng Ai, Hao Chi, Kathy L. Li, et al. "Immunopurification and Mass Spectrometry Identifies Protein Phosphatase 2A (PP2A) and BIN2/GSK3 as Regulators of AKS Transcription Factors in Arabidopsis." Molecular Plant 10, no. 2 (February 2017): 345–48. http://dx.doi.org/10.1016/j.molp.2016.09.016.

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33

Li, Jianfang, Huapeng Zhou, Yan Zhang, Zhen Li, Yongqing Yang, and Yan Guo. "The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana." Developmental Cell 55, no. 3 (November 2020): 367–80. http://dx.doi.org/10.1016/j.devcel.2020.08.005.

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34

Koh, Serry, Sang-Choon Lee, Min-Kyung Kim, Jun Ho Koh, Sichul Lee, Gynheung An, Sunghwa Choe, and Seong-Ryong Kim. "T-DNA tagged knockout mutation of rice OsGSK1, an orthologue of Arabidopsis BIN2, with enhanced tolerance to various abiotic stresses." Plant Molecular Biology 65, no. 4 (August 10, 2007): 453–66. http://dx.doi.org/10.1007/s11103-007-9213-4.

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35

Ye, H., L. Li, H. Guo, and Y. Yin. "MYBL2 is a substrate of GSK3-like kinase BIN2 and acts as a corepressor of BES1 in brassinosteroid signaling pathway in Arabidopsis." Proceedings of the National Academy of Sciences 109, no. 49 (November 19, 2012): 20142–47. http://dx.doi.org/10.1073/pnas.1205232109.

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36

Xiong, Fangjie, Rui Zhang, Zhigang Meng, Kexuan Deng, Yumei Que, Fengping Zhuo, Li Feng, Sundui Guo, Raju Datla, and Maozhi Ren. "Brassinosteriod Insensitive 2 (BIN2) acts as a downstream effector of the Target of Rapamycin (TOR) signaling pathway to regulate photoautotrophic growth in Arabidopsis." New Phytologist 213, no. 1 (August 1, 2016): 233–49. http://dx.doi.org/10.1111/nph.14118.

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37

Zhang, Wenbin, Yang Tang, Yilong Hu, Yuhua Yang, Jiajia Cai, Hailun Liu, Chunyu Zhang, Xu Liu, and Xingliang Hou. "Arabidopsis NF-YCs play dual roles in repressing brassinosteroid biosynthesis and signaling during light-regulated hypocotyl elongation." Plant Cell 33, no. 7 (April 19, 2021): 2360–74. http://dx.doi.org/10.1093/plcell/koab112.

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Abstract Light functions as the primary environmental stimulus and brassinosteroids (BRs) as important endogenous growth regulators throughout the plant lifecycle. Photomorphogenesis involves a series of vital developmental processes that require the suppression of BR-mediated seedling growth, but the mechanism underlying the light-controlled regulation of the BR pathway remains unclear. Here, we reveal that nuclear factor YC proteins (NF-YCs) function as essential repressors of the BR pathway during light-controlled hypocotyl growth in Arabidopsis thaliana. In the light, NF-YCs inhibit BR biosynthesis by directly targeting the promoter of the BR biosynthesis gene BR6ox2 and repressing its transcription. NF-YCs also interact with BIN2, a critical repressor of BR signaling, and facilitate its stabilization by promoting its Tyr200 autophosphorylation, thus inhibiting the BR signaling pathway. Consistently, loss-of-function mutants of NF-YCs show etiolated growth and constitutive BR responses, even in the light. Our findings uncover a dual role of NF-YCs in repressing BR biosynthesis and signaling, providing mechanistic insights into how light antagonizes the BR pathway to ensure photomorphogenic growth in Arabidopsis.

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38

He, Guanhua, Jie Liu, Huixue Dong, and Jiaqiang Sun. "The Blue-Light Receptor CRY1 Interacts with BZR1 and BIN2 to Modulate the Phosphorylation and Nuclear Function of BZR1 in Repressing BR Signaling in Arabidopsis." Molecular Plant 12, no. 5 (May 2019): 689–703. http://dx.doi.org/10.1016/j.molp.2019.02.001.

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39

Breda, Alice S., Ora Hazak, and Christian S. Hardtke. "Phosphosite charge rather than shootward localization determines OCTOPUS activity in root protophloem." Proceedings of the National Academy of Sciences 114, no. 28 (June 26, 2017): E5721—E5730. http://dx.doi.org/10.1073/pnas.1703258114.

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Polar cellular localization of proteins is often associated with their function and activity. In plants, relatively few polar-localized factors have been described. Among them, the plasma membrane-associated Arabidopsis proteins OCTOPUS (OPS) and BREVIS RADIX (BRX) display shootward and rootward polar localization, respectively, in developing root protophloem cells. Both ops and brx null mutants exhibit defects in protophloem differentiation. Here we show that OPS and BRX act genetically in parallel in this process, although OPS dosage increase mends defects caused by brx loss-of-function. OPS protein function is ancient and conserved in the most basal angiosperms; however, many highly conserved structural OPS features are not strictly required for OPS function. They include a BRASSINOSTEROID INSENSITIVE 2 (BIN2) interaction domain, which supposedly mediates gain-of-function effects obtained through ectopic OPS overexpression. However, engineering an increasingly positive charge in a critical phosphorylation site, S318, progressively amplifies OPS activity. Such hyperactive OPS versions can even complement the severe phenotype of brx ops double mutants, and the most active variants eventually trigger gain-of-function phenotypes. Finally, BRX-OPS as well as OPS-BRX fusion proteins localize to the rootward end of developing protophloem cells, but complement ops mutants as efficiently as shootward localized OPS. Thus, our results suggest that S318 phosphorylation status, rather than a predominantly shootward polar localization, is a primary determinant of OPS activity.

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40

Hwang, Hyeona, Hwa-Yong Lee, Hojin Ryu, and Hyunwoo Cho. "Functional Characterization of BRASSINAZOLE-RESISTANT 1 in Panax Ginseng (PgBZR1) and Brassinosteroid Response during Storage Root Formation." International Journal of Molecular Sciences 21, no. 24 (December 18, 2020): 9666. http://dx.doi.org/10.3390/ijms21249666.

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Brassinosteroids (BRs) play crucial roles in the physiology and development of plants. In the model plant Arabidopsis, BR signaling is initiated at the level of membrane receptors, BRASSINOSTEROIDS INSENSITIVE 1 (BRI1) and BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1) complex, thus activating the transcription factors (TFs) BRASSINAZOLE RESISTANT 1/BRI1-EMS-SUPPRESSOR 1 (BZR1/BES1) to coordinate BR responsive genes. BRASSINOSTEROIDS INSENSITIVE 2 (BIN2), glycogen synthase kinase 3 (GSK3) like-kinase, negatively regulates BZR1/BES1 transcriptional activity through phosphorylation-dependent cytosolic retention and shuttling. However, it is still unknown whether this mechanism is conserved in Panax ginseng C. A. Mayer, a member of the Araliaceae family, which is a shade-tolerant perennial root crop. Despite its pharmacological and agricultural importance, the role of BR signaling in the development of P. ginseng and characterization of BR signaling components are still elusive. In this study, by utilizing the Arabidopsisbri1 mutant, we found that ectopic expression of the gain of function form of PgBZR1 (Pgbzr1-1D) restores BR deficiency. In detail, ectopic expression of Pgbzr1-1D rescues dwarfism, defects of floral organ development, and hypocotyl elongation of bri1-5, implying the functional conservation of PgBZR1 in P. ginseng. Interestingly, brassinolide (BL) and BRs biosynthesis inhibitor treatment in two-year-old P. ginseng storage root interferes with and promotes, respectively, secondary growth in terms of xylem formation. Altogether, our results provide new insight into the functional conservation and potential diversification of BR signaling and response in P. ginseng.

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Limpanawat, Suweeraya, Boonhiang Promdonkoy, and Panadda Boonserm. "The C-Terminal Domain of BinA Is Responsible for Bacillus sphaericus Binary Toxin BinA–BinB Interaction." Current Microbiology 59, no. 5 (August 13, 2009): 509–13. http://dx.doi.org/10.1007/s00284-009-9468-x.

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Luo, Tao, Jinliang Gao, Na Lin, and Jinke Wang. "Effects of Two Kinds of Iron Nanoparticles as Reactive Oxygen Species Inducer and Scavenger on the Transcriptomic Profiles of Two Human Leukemia Cells with Different Stemness." Nanomaterials 10, no. 10 (September 30, 2020): 1951. http://dx.doi.org/10.3390/nano10101951.

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Leukemia is a common and lethal disease. In recent years, iron-based nanomedicines have been developed as a new ferroptosis inducer to leukemia. However, the cytotoxicity of iron nanoparticles to leukemia cells at the transcriptomic level remains unclear. This study investigated the effects of two kinds of iron nanoparticles, 2,3-Dimercaptosuccinic acid (DMSA)-coated Fe3O4 nanoparticles (FeNPs) as a reactive oxygen species (ROS) inducer and Prussian blue nanoparticles (PBNPs) as an ROS scavenger, on the transcriptomic profiles of two leukemia cells (KG1a and HL60) by RNA-Seq. As a result, 470 and 1690 differentially expressed genes (DEGs) were identified in the FeNP-treated HL60 and KG1a cells, respectively, and 2008 and 2504 DEGs were found in the PBNP-treated HL60 and KG1a cells, respectively. Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24). The gene ontology revealed that the mineral absorption pathway was significantly regulated by PBNPs in two cells, whereas the lipid metabolism and HIF-1 signaling pathways were significantly regulated by FeNPs in two cells. This study established the gene signatures of two kinds of nanoparticles in two leukemia cells, which revealed the main biological processes regulated by the two kinds of iron nanoparticles. These data shed new insights into the cytotoxicity of iron nanoparticles that differently regulate ROS in leukemia cells with variant stemness.

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Kanwal, Simab, Shalini Abeysinghe, Monrudee Srisaisup, and Panadda Boonserm. "Cytotoxic Effects and Intracellular Localization of Bin Toxin from Lysinibacillus sphaericus in Human Liver Cancer Cell Line." Toxins 13, no. 4 (April 19, 2021): 288. http://dx.doi.org/10.3390/toxins13040288.

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Binary toxin (Bin toxin), BinA and BinB, produced by Lysinibacillus sphaericus has been used as a mosquito-control agent due to its high toxicity against the mosquito larvae. The crystal structures of Bin toxin and non-insecticidal but cytotoxic parasporin-2 toxin share some common structural features with those of the aerolysin-like toxin family, thus suggesting a common mechanism of pore formation of these toxins. Here we explored the possible cytotoxicity of Bin proteins (BinA, BinB and BinA + BinB) against Hs68 and HepG2 cell lines. The cytotoxicity of Bin proteins was evaluated using the trypan blue exclusion assay, MTT assay, morphological analysis and LDH efflux assay. The intracellular localization of Bin toxin in HepG2 cells was assessed by confocal laser scanning microscope. HepG2 cells treated with BinA and BinB (50 µg/mL) showed modified cell morphological features and reduced cell viability. Bin toxin showed no toxicity against Hs68 cells. The EC50 values against HepG2 at 24 h were 24 ng/mL for PS2 and 46.56 and 39.72 µg/mL for BinA and BinB, respectively. The induction of apoptosis in treated HepG2 cells was confirmed by upregulation of caspase levels. The results indicated that BinB mediates the translocation of BinA in HepG2 cells and subsequently associates with mitochondria. The study supports the possible development of Bin toxin as either an anticancer agent or a selective delivery vehicle of anticancer agents to target mitochondria of human cancer cells in the future.

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Ruck, Michael, and Silke Hampel. "Stabilization of homonuclear Bi5+ and Bi62+ polycations by cluster anions in the crystal structures of Bi12−xIrCl13−x, Bi12−xRhCl13−x and Bi12−xRhBr13−x." Polyhedron 21, no. 5-6 (March 2002): 651–56. http://dx.doi.org/10.1016/s0277-5387(01)01025-7.

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Tharad, Sudarat, Chontida Tangsongcharoen, Panadda Boonserm, José L. Toca-Herrera, and Kanokporn Srisucharitpanit. "Local conformations affect the histidine tag-Ni²⁺ binding affinity of BinA and BinB proteins." AIMS Biophysics 7, no. 3 (2020): 133–43. http://dx.doi.org/10.3934/biophy.2020011.

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Graff, Richard B., Gina Green, and Myrna E. Libby. "Effects of two levels of treatment intensity on a young child with severe disabilities." Behavioral Interventions 13, no. 1 (February 1998): 21–41. http://dx.doi.org/10.1002/(sici)1099-078x(199802)13:1<21::aid-bin2>3.0.co;2-c.

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Graff, Richard B., Gina Green, and Myrna E. Libby. "Effects of two levels of treatment intensity on a young child with severe disabilities." Behavioral Interventions 13, no. 1 (February 1998): 21–41. http://dx.doi.org/10.1002/(sici)1099-078x(199802)13:1<21::aid-bin2>3.3.co;2-3.

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Jia, Bing Bing. "Remarks by Bing Bing Jia." Proceedings of the ASIL Annual Meeting 107 (2013): 346–48. http://dx.doi.org/10.5305/procannmeetasil.107.0346.

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Hire, Ramesh S., Mahima Sharma, Ashok B. Hadapad, and Vinay Kumar. "An oligomeric complex of BinA/BinB is not formed in-situ in mosquito-larvicidal Lysinibacillus sphaericus ISPC-8." Journal of Invertebrate Pathology 122 (October 2014): 44–47. http://dx.doi.org/10.1016/j.jip.2014.08.005.

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Bustamante Rosero, Ana. "SUZANNE BING, EL LEGADO DE UNA MAESTRA OLVIDADA." Acotaciones. Revista de Investigación y Creación Teatral 45 (December 18, 2020): 37–64. http://dx.doi.org/10.32621/acotaciones.2020.45.02.

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This article focuses on the life and legacy of Suzanne Bing. She was the pedagogical director and driving force behind the actor’s training research at Théâtre du Vieux Colombier. She played a deci- sive role in the apprenticeship and pedagogical process of an entire ge- neration of practitioners that changed 20th-century European theatre. This brief overview is revealed as a necessity because her figure, despite being crucial in the emergence of physical theatres, has been excluded and forgotten by Theatre’s history. It is a need to restore and contribute to the diffusion of her eminently pedagogical legacy that is linked to the practices of gestural theatre and corporeal mime. Such obliteration leads us to inquire about the mechanisms that made it possible as well as to consider new perspectives in theatre studies. In this path, we em- brace the consideration of a maternal and multiple embodied genealogy of actor's training enabling theatre studies to consider in a more com- plete perspective the great practical innovations that took place in co- llaborative and collective ecosystems where men and women activated and multiplied the practical transmission of their embodied knowledge and acting reforms.

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