Academic literature on the topic 'Binding action'

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Journal articles on the topic "Binding action"

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Kirsch, Wladimir, Roland Pfister, and Wilfried Kunde. "Spatial action-effect binding." Attention, Perception, & Psychophysics 78, no. 1 (2015): 133–42. http://dx.doi.org/10.3758/s13414-015-0997-z.

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Schwarz, Katharina A., Lisa Weller, Roland Pfister, and Wilfried Kunde. "Connecting action control and agency: Does action-effect binding affect temporal binding?" Consciousness and Cognition 76 (November 2019): 102833. http://dx.doi.org/10.1016/j.concog.2019.102833.

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Di Costa, Steven, Héloïse Théro, Valérian Chambon, and Patrick Haggard. "Try and try again: Post-error boost of an implicit measure of agency." Quarterly Journal of Experimental Psychology 71, no. 7 (2018): 1584–95. http://dx.doi.org/10.1080/17470218.2017.1350871.

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The sense of agency refers to the feeling that we control our actions and, through them, effects in the outside world. Reinforcement learning provides an important theoretical framework for understanding why people choose to make particular actions. Few previous studies have considered how reinforcement and learning might influence the subjective experience of agency over actions and outcomes. In two experiments, participants chose between two action alternatives, which differed in reward probability. Occasional reversals of action–reward mapping required participants to monitor outcomes and a
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Diedrichsen, Jörn, and Eliot Hazeltine. "Unifying by binding: Will binding really bind?" Behavioral and Brain Sciences 24, no. 5 (2001): 884–85. http://dx.doi.org/10.1017/s0140525x01260105.

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The theory of event coding by Hommel et al. proposes that feature binding is a central component of action planning. To evaluate the binding hypothesis, we consider findings from studies of action-perception interference and bimanual movements. We argue that although binding of action features may be a valuable concept, interference from partial feature overlap does not provide a parsimonious account for the observed phenomena.
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Mocke, Viola, Lisa Weller, Christian Frings, Klaus Rothermund, and Wilfried Kunde. "Task relevance determines binding of effect features in action planning." Attention, Perception, & Psychophysics 82, no. 8 (2020): 3811–31. http://dx.doi.org/10.3758/s13414-020-02123-x.

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Abstract Action planning can be construed as the temporary binding of features of perceptual action effects. While previous research demonstrated binding for task-relevant, body-related effect features, the role of task-irrelevant or environment-related effect features in action planning is less clear. Here, we studied whether task-relevance or body-relatedness determines feature binding in action planning. Participants planned an action A, but before executing it initiated an intermediate action B. Each action relied on a body-related effect feature (index vs. middle finger movement) and an e
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Buehner, Marc J. "Understanding the Past, Predicting the Future." Psychological Science 23, no. 12 (2012): 1490–97. http://dx.doi.org/10.1177/0956797612444612.

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Temporal binding refers to a subjective shortening of elapsed time between actions and their resultant consequences. Originally, it was thought that temporal binding is specific to motor learning and arises as a consequence of either sensory adaptation or the associative principles of the forward model of motor command. Both of these interpretations assume that the binding effect is rooted in the motor system and, critically, that it is driven by intentional action planning. The research reported here demonstrates that both intentional actions and mechanical causes result in temporal binding,
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Binetti, N., N. Hagura, C. Fadipe, A. Tomassini, V. Walsh, and S. Bestmann. "Binding space and time through action." Proceedings of the Royal Society B: Biological Sciences 282, no. 1805 (2015): 20150381. http://dx.doi.org/10.1098/rspb.2015.0381.

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Space and time are intimately coupled dimensions in the human brain. Several lines of evidence suggest that space and time are processed by a shared analogue magnitude system. It has been proposed that actions are instrumental in establishing this shared magnitude system. Here we provide evidence in support of this hypothesis, by showing that the interaction between space and time is enhanced when magnitude information is acquired through action. Participants observed increases or decreases in the height of a visual bar (spatial magnitude) while judging whether a simultaneously presented seque
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Lush, Peter, Emilie A. Caspar, Axel Cleeremans, Patrick Haggard, Pedro Alexandre Magalhães De Saldanha da Gama, and Zoltan Dienes. "The Power of Suggestion: Posthypnotically Induced Changes in the Temporal Binding of Intentional Action Outcomes." Psychological Science 28, no. 5 (2017): 661–69. http://dx.doi.org/10.1177/0956797616687015.

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The sense of agency is the experience of initiating and controlling one’s voluntary actions and their outcomes. Intentional binding (i.e., when voluntary actions and their outcomes are perceived to occur closer together in time than involuntary actions and their outcomes) is increased in intentional action but requires no explicit reflection on agency. The reported experience of involuntariness is central to hypnotic responding, during which strategic action is experienced as involuntary. We report reduced intentional binding in a hypnotically induced experience of involuntariness, providing a
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Eder, Andreas B., Thorsten M. Erle, and Wilfried Kunde. "Reward strengthens action–effect binding." Motivation Science 6, no. 3 (2020): 297–302. http://dx.doi.org/10.1037/mot0000153.

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Suzuki, Keisuke, Peter Lush, Anil K. Seth, and Warrick Roseboom. "Intentional Binding Without Intentional Action." Psychological Science 30, no. 6 (2019): 842–53. http://dx.doi.org/10.1177/0956797619842191.

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The experience of authorship over one’s actions and their consequences—sense of agency—is a fundamental aspect of conscious experience. In recent years, it has become common to use intentional binding as an implicit measure of the sense of agency. However, it remains contentious whether reported intentional-binding effects indicate the role of intention-related information in perception or merely represent a strong case of multisensory causal binding. Here, we used a novel virtual-reality setup to demonstrate identical magnitude-binding effects in both the presence and complete absence of inte
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Dissertations / Theses on the topic "Binding action"

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Andree, Henricus Adrianus Maria. "Phospholipid binding and anticoagulant action of Annexin V." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1992. http://arno.unimaas.nl/show.cgi?fid=5692.

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Hong, Eui-ju. "Regulation of androgen action by sex hormone-binding globulin." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/35861.

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Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expressed in proximal convoluted tubule (PCT) epithelial cells in a transgenic mouse model. Unlike hepatocytes which actively secrete SHBG and retain little immunoreactive SHBG within their cytoplasm, an incompletely glycosylated SHBG isoform has been found to accumulate inside PCT cells. These cells are
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Mongeau, Raymond. "Antidepressant and anxiolytic action on the Serotonin1A binding site." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59934.

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Several lines of evidence suggest an involvement of serotonin$ sb{ rm 1A}$ (5-HT$ sb{ rm 1A}$ receptors in the regulation of emotions. In order to investigate the molecular basis of recent electrophysiological findings which implicated 5-HT$ sb{ rm 1A}$ receptors in the mechanism of action of antidepressants and anxiolytics, radioligand binding and autoradiographic studies using tritiated 8-hydroxy-2-(di-N-propylamino)-tetralin ( ($ sp3$H) -8-OH-DPAT) were done in rat brain following various treatments. These included: the tricyclic antidepressant imipramine; the reuptake blockers paroxetine a
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Duan, Xuchen. "Physiological and biological mechanisms of bisphosphonate action." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:36b0439d-2f89-4c1e-8bb3-941b4e6ee847.

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Bisphosphonates (BPs) are stable analogues of pyrophosphate widely used for the treatment of bone diseases characterised by increased bone resorption. Studies over the years have shown that the pharmacological potencies of BPs are dependent both on their binding affinities for bone mineral and on their inhibitory actions on osteoclasts. In addition, potential effects on other cell types present locally in the environment of skeletal tissues have been reported. The present study systematically evaluated the relative mineral-binding affinities of individual BPs of clinically relevance in mixture
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Williams, Maro R. I. 1974. "Dehydroepiandrosterone action in the cardiovascular system." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/7927.

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Robertson, Steven Ernest. "Receptor concentration affects glucocorticoid action." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6885.

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Thesis (PhD)--Stellenbosch University, 2011.<br>See also the post-print version of the article that was published from the PhD - http://hdl.handle.net/10019.1/19557<br>ENGLISH ABSTRACT: Glucocorticoid receptor (GR) levels, which modulate the response to glucocorticoids (GCs), vary between tissues and individuals and are altered by physiological and pharmacological effectors. In this study we set out to investigate the effects and implications of differences in GR concentration. Firstly, we established conditions that resulted in three statistically different GR populations in transiently t
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Bhosle, G. "Arginine-rich tat- and (R-X-R)-motif peptidomimetics for DNA/RNA binding, antimicrobial action and cell penetration." Thesis(Ph.D.), CSIR- National Chemical Laboratory, Pune, 2018. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/4545.

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Benyoucef, Samira. "IR/IGFR hybrids : tools for studying insulin and IGF-1 binding and action." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613706.

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Payne, Sarah Louise. "Structure function relationships and mechanisms of agonist action at the human D←2←(←s←h←o←r←t←) dopamine receptor." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270213.

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Notenboom, Valerie. "Crystallographic studies of carbohydrate modifying proteins, mechanisms of action in polysaccharide binding and catalysis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0023/NQ49935.pdf.

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Books on the topic "Binding action"

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Florance, Valerie. Next-generation IAIMS: Binding knowledge to effective action. Association of American Medical Colleges, 2002.

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Lappalainen, Pekka. Actin-Monomer-Binding Proteins. Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-46407-7.

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D, Lappalainen Pekka Ph, ed. Actin-monomer-binding proteins. Landes Bioscience, 2007.

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dos Remedios, Cristobal G., and Deepak Chhabra, eds. Actin-Binding Proteins and Disease. Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-71749-4.

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G, Dos Remedios Cristobal, and Chhabra Deepak, eds. Actin-binding proteins and disease. Springer, 2008.

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G, Dos Remedios Cristobal, and Chhabra Deepak, eds. Actin-binding proteins and disease. Springer, 2008.

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Zvi, Laron, Parks John S, and Ares-Serono Symposia, eds. Lessons from Laron syndrome (LS) 1966-1992: A model of GH and IGF-1 action and interaction : Ares-Serono Symposium, Lisbon, May 25-26, 1992. Karger, 1993.

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Remedios, Cristobal G. Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins. Springer Berlin Heidelberg, 2001.

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Hartwig, John H. Actin-binding proteins 1: spectrin superfamily. Academic Press, 1994.

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Hartwig, John H. Actin-binding proteins 1: Spectrin superfamily. Academic Press, 1994.

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Book chapters on the topic "Binding action"

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Brodbelt, Jennifer S., and Zhe Xu. "Ligand Binding to Nucleic Acids." In Physical Chemistry in Action. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54842-0_9.

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Ogawa, Wataru, Takashi Matozaki, and Masato Kasuga. "Role of binding proteins to IRS-1 in insulin signalling." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_2.

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Soderlund, David M., Jeffrey R. Bloomquist, Gregory T. Payne, and James A. Ottea. "Pharmacological Characterization of Insecticide-Binding Domains of the Voltage-Sensitive Sodium Channel." In Insecticide Action. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-1324-3_5.

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Estébanez-Perpiñá, Eva, and Robert J. Fletterick. "The Androgen Receptor Coactivator-Binding Interface." In Androgen Action in Prostate Cancer. Springer US, 2009. http://dx.doi.org/10.1007/978-0-387-69179-4_13.

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Hayball, P. J., and D. Mauleón. "Enantioselective Plasma and Tissue Binding." In Stereochemical Aspects of Drug Action and Disposition. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-55842-9_12.

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De Meyts, Pierre, Waseem Sajid, Jane Palsgaard, et al. "Insulin and IGF-I Receptor Structure and Binding Mechanism." In Mechanisms of Insulin Action. Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-72204-7_1.

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Liu, Feng, and Richard A. Roth. "Binding of SH2 containing proteins to the insulin receptor: A new way for modulating insulin signalling." In Insulin Action. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5647-3_8.

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Egner, U. "Structural Analysis of the GR Ligand-Binding Domain." In Recent Advances in Glucocorticoid Receptor Action. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04660-9_19.

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Klebe, G. "Mechanisms of Stereoselective Binding to Functional Proteins." In Stereochemical Aspects of Drug Action and Disposition. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-55842-9_8.

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Heidelberger, Charles. "The Relation of Protein Binding to Hydrocarbon Carcinogenesis." In Ciba Foundation Symposium - Carcinogenesis: Mechanisms of Action. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470719138.ch14.

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Conference papers on the topic "Binding action"

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Al-Radhawi, M. Ali, Krishna Manoj, Dhruv D. Jatkar, Alon Duvall, Domitilla Del Vecchio, and Eduardo D. Sontag. "Competition for binding targets results in paradoxical effects for simultaneous activator and repressor action." In 2024 IEEE 63rd Conference on Decision and Control (CDC). IEEE, 2024. https://doi.org/10.1109/cdc56724.2024.10886331.

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Lonika, Charistika, Dono Indarto, and Amelya Augusthina Ayusari. "Roseoside from Lemon Fruits (<i>Citrus limon)</i> as a Potential Inhibitor of Cluster of Differentiation 36 for Obesity Treatment." In 8th International Conference on Advanced Material for Better Future. Trans Tech Publications Ltd, 2025. https://doi.org/10.4028/p-vo3mlu.

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Obesity is a global health problem that prevalence has increased in the last decade. Triglycerides are the main fat component in daily food intake, which can be absorbed directly into the enterocytes through Cluster of Differentiation (CD) 36 transporter protein. Glucagon-like peptide 1 receptor agonist (semaglutide) has recently been approved for obesity treatment, but this medicine has some side effects in the gastrointestinal tract. Administration of Lactobacillus-fermented lemon juice reduced serum triglyceride levels and body weight (BW) of obese rats but it is not related to the action o
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Scully, John R., Hakan Dogan, Daoming Li, and Richard P. Gangloff. "Controlling Hydrogen Embrittlement in Ultra-High Strength Steels." In CORROSION 2004. NACE International, 2004. https://doi.org/10.5006/c2004-04563.

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Abstract A Fe-13Co-11Ni-3Cr-1Mo-0.2C steel alloy, processed for ultra-high strength and fracture toughness, exhibits three distinct hydrogen trap states in a complex precipitation hardened martensitic microstructure and is susceptible to severe hydrogen embrittlement (HE) at threshold stress intensity levels as low as 20 MPa√m. The causes of HE susceptibility include very high crack-tip tensile stresses and a reservoir of diffusible hydrogen that is trapped reversibly with a binding energy, Eb, of 11.5±0.5 kJ/mol at (Fe,Cr,Mo)2C precipitates. This reversibly trapped hydrogen repartitions to in
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Lin, S., G. Voordouw, and Dennis Coombe. "Sulfur Production Associated with Souring Control by Nitrate Injection: a Potential Corrosion Risk?" In CORROSION 2008. NACE International, 2008. https://doi.org/10.5006/c2008-08662.

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Abstract Injection of nitrate into an oil field can significantly reduce the concentration of sulfide produced by endogenous sulfate-reducing bacteria (SRB). Although much is known of the effects of nitrate in relatively high temperature reservoirs (60-80 °C), flooded with seawater, its effectiveness in lower temperature reservoirs (30-40 °C) subjected to produced water reinjection (PWRI) is less well understood. The nitrate-reducing, sulfide-oxidizing bacterium (NR-SOB) Thiomicrospira sp. strain CVO, was isolated from such a reservoir. This organism converts sulfide and nitrate into sulfate a
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Waters, Max, Lin Padgham, and Sebastian Sardina. "Optimising Partial-Order Plans Via Action Reinstantiation." In Twenty-Ninth International Joint Conference on Artificial Intelligence and Seventeenth Pacific Rim International Conference on Artificial Intelligence {IJCAI-PRICAI-20}. International Joint Conferences on Artificial Intelligence Organization, 2020. http://dx.doi.org/10.24963/ijcai.2020/573.

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This work investigates the problem of optimising a partial-order plan’s (POP) flexibility through the simultaneous transformation of its action ordering and variable binding constraints. While the former has been extensively studied through the notions of deordering and reordering, the latter has received much less attention. We show that a plan’s variable bindings are often related to resource usage and their reinstantiation can yield more flexible plans. To do so, we extend existing POP optimality criteria to support variable reinstantiation, and prove that checking if a plan can be optimise
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Kazakos, Evangelos, Arsha Nagrani, Andrew Zisserman, and Dima Damen. "EPIC-Fusion: Audio-Visual Temporal Binding for Egocentric Action Recognition." In 2019 IEEE/CVF International Conference on Computer Vision (ICCV). IEEE, 2019. http://dx.doi.org/10.1109/iccv.2019.00559.

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Sattarova, Z., R. Safin, and D. Prosvirnikov. "TECHNOLOGY OF PRODUCING COMPOSITE PAVERS OF CONTINUOUS ACTION." In Modern machines, equipment and IT solutions for industrial complex: theory and practice. FSBE Institution of Higher Education Voronezh State University of Forestry and Technologies named after G.F. Morozov, 2021. http://dx.doi.org/10.34220/mmeitsic2021_124-129.

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Rational use of natural resources, and the involvement of wood waste generated in the logging and wood processing industry in the production of new products useful for society and the economy, is an urgent task of modern production. The use of wood flour of various fractions does not allow the most complete binding of the polymer to wood particles, since the cellulose polymer has a high polarity. This problem can be solved by soft contact thermal modification, as a result of which there is an increase in strength indicators and a decrease in the degree of water absorption. Thermomodification l
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Shen, Bingjun, Lihong Jin, Hongyan Wang, and Jian Tian. "Spectroscopic study of the binding action between naringenin and human serum albumin." In 2013 International Conference on Biomedical Engineering and Environmental Engineering. WIT Press, 2014. http://dx.doi.org/10.2495/icbeee130171.

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Zhang, Xinye, Lipeng Qin, Xuehan Sun, Long Cheng, Ming Guo, and Xiangyong Chen. "Inertial Sensor Binding Position and Combination in Badminton Action Recognition Using Machine Learning." In 2023 IEEE 13th International Conference on CYBER Technology in Automation, Control, and Intelligent Systems (CYBER). IEEE, 2023. http://dx.doi.org/10.1109/cyber59472.2023.10256491.

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Oleinik, G. A., P. V. Zhdanova, and S. V. Baranova. "ESTABLISHMENT OF THE ICE-BINDING PROTEIN’S SECONDARY STRUCTURE FROM MYOXOCEPHALUS OCTODECEMSPINOSUS BY THE CIRCULAR DICHROISM METHOD." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-109.

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Organisms living in the cold zone produce ice-binding proteins. These proteins are able to bind to ice crystals and reduce cell damage when the temperature drops. It is necessary to know the structure of such proteins and the mechanism of their binding to ice in order to effectively use the properties of IBPs in medicine and industry. This study contributes to the study of the structural and dynamic mechanisms of action of ice-binding proteins.
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Reports on the topic "Binding action"

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Choudhary, Ruplal, Victor Rodov, Punit Kohli, Elena Poverenov, John Haddock, and Moshe Shemesh. Antimicrobial functionalized nanoparticles for enhancing food safety and quality. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7598156.bard.

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Original objectives The general goal of the project was to utilize the bactericidal potential of curcumin- functionalizednanostructures (CFN) for reinforcement of food safety by developing active antimicrobial food-contact surfaces. In order to reach the goal, the following secondary tasks were pursued: (a) further enhancement of the CFN activity based on understanding their mode of action; (b) preparing efficient antimicrobial surfaces, investigating and optimizing their performance; (c) testing the efficacy of the antimicrobial surfaces in real food trials. Background to the topic The projec
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Levy, Maggie, Raymond Zielinski, and Anireddy S. Reddy. IQD1 Function in Defense Responses. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7699842.bard.

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The main objective of the proposed research was to study IQD1's mechanism of action and elucidate its role in plant protection. Preliminary experiments suggest that IQD1 binds CaM in a Ca²⁺-dependent manner and functions in general defense responses. We propose to identify proteins and genes that interact with IQD1, which may provide some clues to its mechanism of action. We also plan to dissect IQD1's integration in defense pathways and to study and modulate its binding affinity to CaM in order to enhance crop resistance. Our specific objectives were: (1) Analysis of IQD1's CaM-binding proper
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Alexander, Serena E., Ahoura Zandiatashbar, and Branka Tatarevic. Fragmented or Aligned Climate Action: Assessing Linkages Between Regional and Local Planning Efforts to Meet Transportation Greenhouse Gas Emissions Reduction Targets. Mineta Transportation Institute, 2022. http://dx.doi.org/10.31979/mti.2022.2146.

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Amid the rising climate change concerns, California enacted Senate Bill 375 (SB 375) to tackle transportation greenhouse gas (GHG) emissions. SB 375 requires Metropolitan Planning Organizations (MPOs) to develop a Sustainable Communities Strategy (SCS), a regional transportation and land use vision plan, to reduce GHG emissions. Meanwhile, a local government can develop a Climate Action Plan (CAP), a non-binding, voluntary plan to reduce GHG emissions that may align with the regional SCS. Recent progress reports indicate California is not making sufficient progress to meet SB 375 emissions red
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Rahimipour, Shai, and David Donovan. Renewable, long-term, antimicrobial surface treatments through dopamine-mediated binding of peptidoglycan hydrolases. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597930.bard.

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There is a need for renewable antimicrobial surface treatments that are semi- permanent, can eradicate both biofilms and planktonic pathogens over long periods of time and that do not select for resistant strains. This proposal describes a dopamine binding technology that is inexpensive, bio-friendly, non-toxic, and uses straight-forward commercially available products. The antimicrobial agents are peptidoglycanhydrolase enzymes that are non-toxic and highly refractory to resistance development. The goal of this project is to create a treatment that will be applicable to a wide variety of surf
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Gurevitz, Michael, Michael Adams, and Eliahu Zlotkin. Insect Specific Alpha Neurotoxins from Scorpion Venoms: Mode of Action and Structure-Function Relationships. United States Department of Agriculture, 1996. http://dx.doi.org/10.32747/1996.7613029.bard.

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This study was motivated by the need to develop new means and approaches to the design of future, environmentally-safe, insecticides. Utilization of anti-insect selective toxins from scorpion venoms and clarification of the molecular basis for their specificity, are a major focus in this project and may have an applicative value. Our study concentrated on the highly insecticidal toxin, LqhaIT, and was devoted to: (I) Characterization of the neuropharmacological and electrophysiological features of this toxin. (II) Establishment of a genetic system for studying structure/activity relationships
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Wisniewski, Michael, Samir Droby, John Norelli, Dov Prusky, and Vera Hershkovitz. Genetic and transcriptomic analysis of postharvest decay resistance in Malus sieversii and the identification of pathogenicity effectors in Penicillium expansum. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597928.bard.

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Use of Lqh2 mutants (produced at TAU) and rNav1.2a mutants (produced at the US side) for identifying receptor site-3: Based on the fact that binding of scorpion alpha-toxins is voltage-dependent, which suggests toxin binding at the mobile voltage-sensing region, we analyzed which of the toxin bioactive domains (Core-domain or NC-domain) interacts with the DIV Gating-module of rNav1.2a. This analysis was based on the assumption that the dissociation of toxin mutants upon depolarization would vary from that of the unmodified toxin should the substitutions affect a site of interaction with the ch
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Boisclair, Yves R., Alan W. Bell, and Avi Shamay. Regulation and Action of Leptin in Pregnant and Lactating Dairy Cows. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7586465.bard.

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The original project had four specific objectives: (1) To complete the development of a radioimmunoassay for bovine leptin; (2) To characterize the leptin system in lactating dairy cows during the transition from pregnancy to lactation; (3) To identify endocrine factors regulating the production of leptin by bovine adipose tissue; (4) To study the actions of leptin on bovine adipose and mammary tissues in vitro. However, BARD funded only the development of the bovine leptin RIA (Objective 1) for a single year. This report describes our work in completing this objective. Leptin, a protein hormo
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Boisclair, Yves R., and Arieh Gertler. Development and Use of Leptin Receptor Antagonists to Increase Appetite and Adaptive Metabolism in Ruminants. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7697120.bard.

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Objectives The original project had 2 major objectives: (1) To determine the effects of centrally administered leptin antagonist on appetite and adaptive metabolism in the sheep; (2) To develop and prepare second-generation leptin antagonists combining high binding affinity and prolonged in vivo half-life. Background Periods of suboptimal nutrition or exaggerated metabolic activity demands lead to a state of chronic energy insufficiency. Ruminants remain productive for a surprisingly long period of time under these circumstances by evoking adaptations sparing available energy and nutrients. Th
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Gurevitz, Michael, Michael E. Adams, Boaz Shaanan, et al. Interacting Domains of Anti-Insect Scorpion Toxins and their Sodium Channel Binding Sites: Structure, Cooperative Interactions with Agrochemicals, and Application. United States Department of Agriculture, 2001. http://dx.doi.org/10.32747/2001.7585190.bard.

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Integrated pest management in modern crop protection may combine chemical and biological insecticides, particularly due to the risks to the environment and livestock arising from the massive use of non-selective chemicals. Thus, there is a need for safer alternatives, which target insects more specifically. Scorpions produce anti-insect selective polypeptide toxins that are biodegradable and non-toxic to warm-blooded animals. Therefore, integration of these substances into insect pest control strategies is of major importance. Moreover, clarification of the molecular basis of this selectivity
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Altstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7587235.bard.

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The general objective of this BARD project focused on rationally designed insect neuropeptide (NP) agonists and antagonists, their application for the characterization of the mechanisms of action of the pyrokinin/PBAN (PK-PBAN) family and the development of biostable, bioavailable versions that can provide the basis for development of novel, environmentally-friendly pest insect control agents. The specific objectives of the study, as originally proposed, were to: (i) Test stimulatory potencies of rationally designed backbone cyclic (BBC) peptides on pheromonotropic, melanotropic, myotropic and
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